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MCID: ARG006
MIFTS: 28

Aregenerative Anemia

Categories: Blood diseases, Rare diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Aregenerative Anemia

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MalaCards integrated aliases for Aregenerative Anemia:

Name: Aregenerative Anemia 58 71
Refractory Anemias 71

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Blood diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare haematological diseases


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Summaries for Aregenerative Anemia

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MalaCards based summary : Aregenerative Anemia, also known as refractory anemias, is related to diamond-blackfan anemia 1 and diamond-blackfan anemia. An important gene associated with Aregenerative Anemia is TBXAS1 (Thromboxane A Synthase 1). The drugs Deferiprone and Iron have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and t cells, and related phenotypes are bone marrow hypocellularity and pallor

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Related Diseases for Aregenerative Anemia

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Diseases related to Aregenerative Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 diamond-blackfan anemia 1 11.6
2 diamond-blackfan anemia 11.4
3 ghosal hematodiaphyseal dysplasia 11.4
4 deficiency anemia 10.7
5 thymoma, familial 10.5
6 thymoma 10.5
7 immune deficiency disease 10.2
8 pancytopenia 10.2
9 glucosephosphate dehydrogenase deficiency 10.2
10 monocytic leukemia 10.2
11 hypoxia 10.2
12 refractory anemia 10.2

Graphical network of the top 20 diseases related to Aregenerative Anemia:



Diseases related to Aregenerative Anemia
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Symptoms & Phenotypes for Aregenerative Anemia

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Human phenotypes related to Aregenerative Anemia:

58 31 (show all 24)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 bone marrow hypocellularity 58 31 hallmark (90%) Very frequent (99-80%) HP:0005528
2 pallor 58 31 hallmark (90%) Very frequent (99-80%) HP:0000980
3 reticulocytopenia 58 31 hallmark (90%) Very frequent (99-80%) HP:0001896
4 fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0012378
5 dyspnea 58 31 frequent (33%) Frequent (79-30%) HP:0002094
6 depressivity 58 31 occasional (7.5%) Occasional (29-5%) HP:0000716
7 fever 58 31 occasional (7.5%) Occasional (29-5%) HP:0001945
8 pancytopenia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001876
9 fatigable weakness of skeletal muscles 58 31 occasional (7.5%) Occasional (29-5%) HP:0030197
10 thrombocytopenia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001873
11 neutropenia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001875
12 bruising susceptibility 58 31 occasional (7.5%) Occasional (29-5%) HP:0000978
13 decreased proportion of cd4-positive t cells 58 31 occasional (7.5%) Occasional (29-5%) HP:0005407
14 mood changes 58 31 occasional (7.5%) Occasional (29-5%) HP:0001575
15 abnormal proportion of cd8 t cells 58 31 occasional (7.5%) Occasional (29-5%) HP:0031393
16 erythroid hypoplasia 58 31 occasional (7.5%) Occasional (29-5%) HP:0012133
17 abnormality of interleukin secretion 58 31 occasional (7.5%) Occasional (29-5%) HP:0011117
18 dementia 58 31 very rare (1%) Very rare (<4-1%) HP:0000726
19 lymphadenopathy 58 31 very rare (1%) Very rare (<4-1%) HP:0002716
20 cognitive impairment 58 Very rare (<4-1%)
21 abnormality of the cardiovascular system 58 Occasional (29-5%)
22 abnormal bleeding 58 Occasional (29-5%)
23 abnormality of immune system physiology 58 Occasional (29-5%)
24 abnormality of bone marrow cell morphology 58 Frequent (79-30%)
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Drugs & Therapeutics for Aregenerative Anemia

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Drugs for Aregenerative Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Deferiprone Approved Phase 3 30652-11-0 2972
2
Iron Approved, Experimental Phase 3 7439-89-6, 15438-31-0 23925 27284
3
Deferoxamine Approved, Investigational Phase 3 70-51-9 2973
4 Siderophores Phase 3
5 Chelating Agents Phase 3
6 Iron Chelating Agents Phase 3
7 Liver Extracts
8 Nutrients
9 Trace Elements
10 Micronutrients

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Open-label Phase III Study With Deferiprone and/or Desferrioxamine in Iron Overloaded Patients Completed NCT00350662 Phase 3 Deferiprone (L1);Desferrioxamine
2 Retrospective and Prospective Multicenter Study Using Deferiprone (L1) Alone or in Combination With Desferrioxamine for the Treatment of Iron Overload in Transfusion-dependent Patients Completed NCT00349453 Phase 2 Deferiprone (L1);Deferiprone (L1);Desferrioxamine
3 High-Tc Susceptometer to Monitor Transfusional Iron Overload (NSR Device) Completed NCT01241357

Search NIH Clinical Center for Aregenerative Anemia

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Genetic Tests for Aregenerative Anemia

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Anatomical Context for Aregenerative Anemia

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MalaCards organs/tissues related to Aregenerative Anemia:

40
Bone, Bone Marrow, T Cells, Monocytes, Skeletal Muscle, Liver, Thymus
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Publications for Aregenerative Anemia

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Articles related to Aregenerative Anemia:

(show top 50) (show all 154)
# Title Authors PMID Year
1
Intrauterine Growth Retardation Complicated by Biermer's Disease: An Observation in Togo. 61
31198611 2019
2
TREATMENT STRATEGIES AND OUTCOME OF PARVOVIRUS B19 INFECTION IN KIDNEY TRANSPLANT RECIPIENTS: A CASE SERIES AND LITERATURE REVIEW OF 128 PATIENTS. 61
31448778 2019
3
Citrobacter freundii infection in silver catfish (Rhamdia quelen): Hematological and histological alterations. 61
30266258 2018
4
Hospital-Based Case-Control Study of MDS Subtypes and Benzene Exposure in Shanghai. 61
28146040 2017
5
Erythroleukemia shares biological features and outcome with myelodysplastic syndromes with excess blasts: a rationale for its inclusion into future classifications of myelodysplastic syndromes. 61
27562492 2016
6
Adult-onset Diamond-Blackfan anemia with a novel mutation in the exon 5 of RPL11: too late and too rare. 61
26185635 2015
7
Iron chelation therapy in transfusion-dependent thalassemia patients: current strategies and future directions. 61
26124688 2015
8
[Refractory anemias]. 61
24195247 2013
9
Immune aregenerative anemia without erythroblastopenia: a previously undescribed condition. 61
23408098 2013
10
Molecular similarity between myelodysplastic form of chronic myelomonocytic leukemia and refractory anemia with ring sideroblasts. 61
23065512 2013
11
[Detecting a peak in fraction beta by capillary electrophoresis: interference due to iomeprol]. 61
23587586 2013
12
How I treat transfusional iron overload. 61
22919029 2012
13
[Aregenerative anemia and erythrocytes hemighosts: a case report]. 61
21896417 2011
14
[Criteria for suspecting a myelodysplastic syndrome]. 61
21425539 2010
15
Genetic variants in the noncoding region of RPS19 gene in Diamond-Blackfan anemia: potential implications for phenotypic heterogeneity. 61
20054847 2010
16
[Neonatal Pearson syndrome. two case studies]. 61
19914050 2010
17
Nandrolone decanoate for the treatment of erythropoietin refractory anemia: a case series. 61
20043618 2009
18
[Pernicious anemia in an adolescent with type 1 diabetes mellitus]. 61
19211232 2009
19
Early neurological impairment and severe anemia in a newborn with Pearson syndrome. 61
18553104 2009
20
Treatment of iron overload in thalassemia. 61
19337180 2008
21
WHO classification and WPSS predict posttransplantation outcome in patients with myelodysplastic syndrome: a study from the Gruppo Italiano Trapianto di Midollo Osseo (GITMO). 61
18497321 2008
22
Treatment options in myelodysplastic syndromes: a new frontier. 61
18606581 2008
23
[Immune pathophysiology of refractory anemias]. 61
18326316 2008
24
Impact of transfusion dependency and secondary iron overload on the survival of patients with myelodysplastic syndromes. 61
18037415 2007
25
Linezolid-related pancytopenia in organ-transplant patients: report of two cases. 61
17653505 2007
26
Unusual complex hyperdiploid karyotypes in myelodysplastic syndromes. 61
17011983 2006
27
Anemia after late introduction of sirolimus may correlate with biochemical evidence of a chronic inflammatory state. 61
16314788 2005
28
Absence of p16 and p27 gene rearrangements and mutations in de novo myelodysplastic syndromes. 61
16104874 2005
29
A comparative review of classification systems in myelodysplastic syndromes (MDS). 61
16085011 2005
30
[Extensive bone marrow necrosis as presenting manifestation of sickle cell disease in Africa]. 61
15460150 2004
31
Increased caspase-3 activity in refractory anemias: lack of evidence for Fas pathway implication. 61
12399987 2002
32
Less apoptosis in patients with 5q-syndrome than in patients with refractory anemia. 61
12163050 2002
33
[Transient erythroblastopenia in the context of Epstein-Barr virus infection]. 61
12042121 2002
34
Morbidity and mortality of chronic GVHD after hematopoietic stem cell transplantation from HLA-identical siblings for patients with aplastic or refractory anemias. 61
11858190 2002
35
Lethal hydrops fetalis due to congenital dyserythropoietic anemia in a newborn: association of a new skeletal abnormality. 61
11764104 2001
36
Thalidomide produces transfusion independence in long-standing refractory anemias of patients with myelodysplastic syndromes. 61
11493439 2001
37
Diamond-Blackfan anemia. 61
11176237 2001
38
Secondary iron overload. 61
11722978 2001
39
[Collagen gastritis, an unusual cause of anemia in children. Report of 2 cases]. 61
11218583 2001
40
Absolute number of circulating CD34+ cells is abnormally low in refractory anemias and extremely high in RAEB and RAEB-t; novel pathologic features of myelodysplastic syndromes identified by highly sensitive flow cytometry. 61
10654453 2000
41
Nutritional anemias. 61
10595751 1999
42
Rheumatoid arthritis associated with myelodysplastic syndrome: a case report. 61
10402176 1999
43
EPR spin trapping and 2-deoxyribose degradation studies of the effect of pyridoxal isonicotinoyl hydrazone (PIH) on *OH formation by the Fenton reaction. 61
10076064 1999
44
CD66c antigen expression is myeloid restricted in normal bone marrow but is a common feature of CD10+ early-B-cell malignancies. 61
9714468 1998
45
Transfusion-associated iron overload. 61
9359002 1997
46
Myelodysplasia and the leukemias. 61
9301644 1997
47
Molecular analysis of the cyclin-dependent kinase inhibitor genes, p15, p16, p18 and p19 in the myelodysplastic syndromes. 61
9111168 1997
48
Iron chelation therapy. 61
9371986 1995
49
Life expectancy in primary myelodysplastic syndromes: a prognostic score based upon histopathology from bone marrow biopsies of 569 patients. 61
7813708 1994
50
Transient erythroblastopenia of childhood in infants < 6 months of age. 61
8037344 1994
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Variations for Aregenerative Anemia

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Expression for Aregenerative Anemia

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Search GEO for disease gene expression data for Aregenerative Anemia.
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Pathways for Aregenerative Anemia

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GO Terms for Aregenerative Anemia

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Sources for Aregenerative Anemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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