MCID: ARG006
MIFTS: 22

Aregenerative Anemia

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Aregenerative Anemia

MalaCards integrated aliases for Aregenerative Anemia:

Name: Aregenerative Anemia 59 72
Refractory Anemias 72

Classifications:



External Ids:

ICD10 via Orphanet 34 D46.7
UMLS via Orphanet 73 C0002893 C0553669
Orphanet 59 ORPHA101096
UMLS 72 C0002893 C0553669

Summaries for Aregenerative Anemia

MalaCards based summary : Aregenerative Anemia, also known as refractory anemias, is related to diamond-blackfan anemia 1 and diamond-blackfan anemia. An important gene associated with Aregenerative Anemia is TBXAS1 (Thromboxane A Synthase 1). The drugs Iron and Deferiprone have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and liver.

Related Diseases for Aregenerative Anemia

Diseases related to Aregenerative Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 diamond-blackfan anemia 1 11.6
2 diamond-blackfan anemia 11.4
3 ghosal hematodiaphyseal dysplasia 11.4
4 deficiency anemia 10.7
5 thymoma, familial 10.5
6 thymoma 10.5
7 immune deficiency disease 10.2
8 pancytopenia 10.2
9 glucosephosphate dehydrogenase deficiency 10.2
10 monocytic leukemia 10.2
11 hypoxia 10.2
12 refractory anemia 10.2

Graphical network of the top 20 diseases related to Aregenerative Anemia:



Diseases related to Aregenerative Anemia

Symptoms & Phenotypes for Aregenerative Anemia

Drugs & Therapeutics for Aregenerative Anemia

Drugs for Aregenerative Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved, Experimental Phase 3 15438-31-0, 7439-89-6 23925 27284
2
Deferiprone Approved Phase 3 30652-11-0 2972
3
Deferoxamine Approved, Investigational Phase 3 70-51-9 2973
4 Siderophores Phase 3
5 Chelating Agents Phase 3
6 Iron Chelating Agents Phase 3
7 Micronutrients
8 Nutrients
9 Liver Extracts
10 Trace Elements

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Open-label Phase III Study With Deferiprone and/or Desferrioxamine in Iron Overloaded Patients Completed NCT00350662 Phase 3 Deferiprone (L1);Desferrioxamine
2 Retrospective and Prospective Multicenter Study Using Deferiprone (L1) Alone or in Combination With Desferrioxamine for the Treatment of Iron Overload in Transfusion-dependent Patients Completed NCT00349453 Phase 2 Deferiprone (L1);Deferiprone (L1);Desferrioxamine
3 High-Tc Susceptometer to Monitor Transfusional Iron Overload (NSR Device) Completed NCT01241357

Search NIH Clinical Center for Aregenerative Anemia

Genetic Tests for Aregenerative Anemia

Anatomical Context for Aregenerative Anemia

MalaCards organs/tissues related to Aregenerative Anemia:

41
Bone, Bone Marrow, Liver, Monocytes, Thymus, B Cells, Myeloid

Publications for Aregenerative Anemia

Articles related to Aregenerative Anemia:

(show top 50) (show all 153)
# Title Authors PMID Year
1
Intrauterine Growth Retardation Complicated by Biermer's Disease: An Observation in Togo. 38
31198611 2019
2
Citrobacter freundii infection in silver catfish (Rhamdia quelen): Hematological and histological alterations. 38
30266258 2018
3
Hospital-Based Case-Control Study of MDS Subtypes and Benzene Exposure in Shanghai. 38
28146040 2017
4
Erythroleukemia shares biological features and outcome with myelodysplastic syndromes with excess blasts: a rationale for its inclusion into future classifications of myelodysplastic syndromes. 38
27562492 2016
5
Adult-onset Diamond-Blackfan anemia with a novel mutation in the exon 5 of RPL11: too late and too rare. 38
26185635 2015
6
Iron chelation therapy in transfusion-dependent thalassemia patients: current strategies and future directions. 38
26124688 2015
7
[Refractory anemias]. 38
24195247 2013
8
Immune aregenerative anemia without erythroblastopenia: a previously undescribed condition. 38
23408098 2013
9
Molecular similarity between myelodysplastic form of chronic myelomonocytic leukemia and refractory anemia with ring sideroblasts. 38
23065512 2013
10
[Detecting a peak in fraction beta by capillary electrophoresis: interference due to iomeprol]. 38
23587586 2013
11
How I treat transfusional iron overload. 38
22919029 2012
12
[Aregenerative anemia and erythrocytes hemighosts: a case report]. 38
21896417 2011
13
[Criteria for suspecting a myelodysplastic syndrome]. 38
21425539 2010
14
Genetic variants in the noncoding region of RPS19 gene in Diamond-Blackfan anemia: potential implications for phenotypic heterogeneity. 38
20054847 2010
15
[Neonatal Pearson syndrome. two case studies]. 38
19914050 2010
16
Nandrolone decanoate for the treatment of erythropoietin refractory anemia: a case series. 38
20043618 2009
17
[Pernicious anemia in an adolescent with type 1 diabetes mellitus]. 38
19211232 2009
18
Early neurological impairment and severe anemia in a newborn with Pearson syndrome. 38
18553104 2009
19
Treatment of iron overload in thalassemia. 38
19337180 2008
20
WHO classification and WPSS predict posttransplantation outcome in patients with myelodysplastic syndrome: a study from the Gruppo Italiano Trapianto di Midollo Osseo (GITMO). 38
18497321 2008
21
Treatment options in myelodysplastic syndromes: a new frontier. 38
18606581 2008
22
[Immune pathophysiology of refractory anemias]. 38
18326316 2008
23
Impact of transfusion dependency and secondary iron overload on the survival of patients with myelodysplastic syndromes. 38
18037415 2007
24
Linezolid-related pancytopenia in organ-transplant patients: report of two cases. 38
17653505 2007
25
Unusual complex hyperdiploid karyotypes in myelodysplastic syndromes. 38
17011983 2006
26
Anemia after late introduction of sirolimus may correlate with biochemical evidence of a chronic inflammatory state. 38
16314788 2005
27
Absence of p16 and p27 gene rearrangements and mutations in de novo myelodysplastic syndromes. 38
16104874 2005
28
A comparative review of classification systems in myelodysplastic syndromes (MDS). 38
16085011 2005
29
[Extensive bone marrow necrosis as presenting manifestation of sickle cell disease in Africa]. 38
15460150 2004
30
Increased caspase-3 activity in refractory anemias: lack of evidence for Fas pathway implication. 38
12399987 2002
31
Less apoptosis in patients with 5q-syndrome than in patients with refractory anemia. 38
12163050 2002
32
[Transient erythroblastopenia in the context of Epstein-Barr virus infection]. 38
12042121 2002
33
Morbidity and mortality of chronic GVHD after hematopoietic stem cell transplantation from HLA-identical siblings for patients with aplastic or refractory anemias. 38
11858190 2002
34
Lethal hydrops fetalis due to congenital dyserythropoietic anemia in a newborn: association of a new skeletal abnormality. 38
11764104 2001
35
Thalidomide produces transfusion independence in long-standing refractory anemias of patients with myelodysplastic syndromes. 38
11493439 2001
36
Diamond-Blackfan anemia. 38
11176237 2001
37
Secondary iron overload. 38
11722978 2001
38
[Collagen gastritis, an unusual cause of anemia in children. Report of 2 cases]. 38
11218583 2001
39
Absolute number of circulating CD34+ cells is abnormally low in refractory anemias and extremely high in RAEB and RAEB-t; novel pathologic features of myelodysplastic syndromes identified by highly sensitive flow cytometry. 38
10654453 2000
40
Nutritional anemias. 38
10595751 1999
41
Rheumatoid arthritis associated with myelodysplastic syndrome: a case report. 38
10402176 1999
42
EPR spin trapping and 2-deoxyribose degradation studies of the effect of pyridoxal isonicotinoyl hydrazone (PIH) on *OH formation by the Fenton reaction. 38
10076064 1999
43
CD66c antigen expression is myeloid restricted in normal bone marrow but is a common feature of CD10+ early-B-cell malignancies. 38
9714468 1998
44
Transfusion-associated iron overload. 38
9359002 1997
45
Myelodysplasia and the leukemias. 38
9301644 1997
46
Molecular analysis of the cyclin-dependent kinase inhibitor genes, p15, p16, p18 and p19 in the myelodysplastic syndromes. 38
9111168 1997
47
Iron chelation therapy. 38
9371986 1995
48
Life expectancy in primary myelodysplastic syndromes: a prognostic score based upon histopathology from bone marrow biopsies of 569 patients. 38
7813708 1994
49
Transient erythroblastopenia of childhood in infants < 6 months of age. 38
8037344 1994
50
Efficacy of recombinant human erythropoietin in the treatment of refractory anemias without excess of blasts in myelodysplastic syndromes. 38
8167562 1994

Variations for Aregenerative Anemia

Expression for Aregenerative Anemia

Search GEO for disease gene expression data for Aregenerative Anemia.

Pathways for Aregenerative Anemia

GO Terms for Aregenerative Anemia

Sources for Aregenerative Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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