MCID: ARG001
MIFTS: 39

Argentine Hemorrhagic Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Argentine Hemorrhagic Fever

MalaCards integrated aliases for Argentine Hemorrhagic Fever:

Name: Argentine Hemorrhagic Fever 12 74 58 29 15
Hemorrhagic Fever, Argentinian 71
Argentinian Hemorrhagic Fever 58
Junin Hemorrhagic Fever 58

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050194
ICD10 32 A96.0
ICD10 via Orphanet 33 A96.0
UMLS via Orphanet 72 C0019097
Orphanet 58 ORPHA319223
UMLS 71 C0019097

Summaries for Argentine Hemorrhagic Fever

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, has material basis in Junin virus, which is transmitted by rodent, Calomys musculinus. The infection has symptom fever, has symptom fatigue, has symptom malaise, has symptom leukopenia, has symptom thrombocytopenia, and has symptom hemorrhagic manifestations.

MalaCards based summary : Argentine Hemorrhagic Fever, also known as hemorrhagic fever, argentinian, is related to hemorrhagic disease and disseminated intravascular coagulation, and has symptoms including fatigue, fever and thrombocytopenia. An important gene associated with Argentine Hemorrhagic Fever is TSG101 (Tumor Susceptibility 101), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 74 Argentine hemorrhagic fever (AHF) or O'Higgins disease, also known in Argentina as mal de los rastrojos... more...

Related Diseases for Argentine Hemorrhagic Fever

Diseases related to Argentine Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 hemorrhagic disease 30.3 SERPINE1 SERPINC1 PLAT
2 disseminated intravascular coagulation 30.3 SERPINE1 SERPINC1 PLAT
3 thrombocytopenia 29.6 TFRC SERPINE1 SERPINC1 PLAT IFNA1
4 lymphocytic choriomeningitis 29.5 DDX58 DAG1 CLEC4G
5 bolivian hemorrhagic fever 27.9 TFRC MBTPS1 GTPBP1 GP2 ERVW-1 DDX58
6 lassa fever 26.8 TSG101 MBTPS1 IFNA1 GTPBP1 GP2 ERVW-1
7 sticky platelet syndrome 10.4 SERPINE1 SERPINC1
8 dic in newborn 10.4 SERPINE1 SERPINC1
9 central serous chorioretinopathy 10.4 SERPINE1 PLAT
10 livedoid vasculitis 10.4 SERPINE1 SERPINC1
11 platelet aggregation, spontaneous 10.4 SERPINC1 PLAT
12 marantic endocarditis 10.4 SERPINC1 PLAT
13 plasminogen activator inhibitor-1 deficiency 10.4 SERPINE1 PLAT
14 meningococcemia 10.4 SERPINE1 SERPINC1
15 thoracic outlet syndrome 10.4 SERPINC1 PLAT
16 blessig's cysts 10.4 GTPBP1 GP2
17 intracranial embolism 10.3 SERPINC1 PLAT
18 central retinal artery occlusion 10.3 SERPINC1 PLAT
19 encephalopathy, familial, with neuroserpin inclusion bodies 10.3 SERPINC1 PLAT
20 coronary restenosis 10.3 SERPINC1 PLAT
21 intracranial thrombosis 10.3 SERPINC1 PLAT
22 ischemic colitis 10.2 SERPINE1 SERPINC1
23 neutropenia 10.2
24 fibrinolytic defect 10.2 SERPINE1 SERPINC1 PLAT
25 dysfibrinogenemia, congenital 10.2 SERPINC1 PLAT
26 carotid artery thrombosis 10.2 SERPINE1 SERPINC1 PLAT
27 post-thrombotic syndrome 10.2 SERPINE1 SERPINC1 PLAT
28 factor xiii deficiency 10.2 SERPINE1 SERPINC1
29 thrombophilia due to activated protein c resistance 10.2 SERPINE1 SERPINC1 PLAT
30 thrombophilia 10.2 SERPINE1 SERPINC1 PLAT
31 thrombophlebitis 10.2 SERPINE1 SERPINC1 PLAT
32 coronary thrombosis 10.2 SERPINE1 SERPINC1 PLAT
33 pulmonary artery disease 10.2 SERPINE1 SERPINC1 PLAT
34 hepatic veno-occlusive disease 10.2 SERPINE1 SERPINC1 PLAT
35 thrombophilia due to thrombin defect 10.2 SERPINE1 SERPINC1 PLAT
36 vein disease 10.2 SERPINE1 SERPINC1 PLAT
37 afibrinogenemia, congenital 10.2 SERPINE1 SERPINC1 PLAT
38 endocarditis 10.2 SERPINE1 SERPINC1 PLAT
39 antiphospholipid syndrome 10.2 SERPINE1 SERPINC1 PLAT
40 pulmonary embolism 10.2 SERPINE1 SERPINC1 PLAT
41 peripheral vascular disease 10.1 SERPINE1 SERPINC1 PLAT
42 patent foramen ovale 10.1 SERPINE1 SERPINC1 PLAT
43 legg-calve-perthes disease 10.1 SERPINE1 SERPINC1
44 cerebral palsy 10.1 SERPINE1 SERPINC1 PLAT
45 hantavirus hemorrhagic fever with renal syndrome 10.1 ERVW-1 DDX58
46 hypotonia 10.0
47 bacterial infectious disease 10.0
48 hepatitis c 10.0
49 thrombocytosis 10.0
50 bone marrow necrosis 10.0

Graphical network of the top 20 diseases related to Argentine Hemorrhagic Fever:



Diseases related to Argentine Hemorrhagic Fever

Symptoms & Phenotypes for Argentine Hemorrhagic Fever

Symptoms:

12
  • fatigue
  • fever
  • thrombocytopenia
  • leukopenia
  • malaise
  • hemorrhagic manifestations

GenomeRNAi Phenotypes related to Argentine Hemorrhagic Fever according to GeneCards Suite gene sharing:

26 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-106 9.66 TSG101
2 Increased shRNA abundance (Z-score > 2) GR00366-A-111 9.66 GTPBP1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-119 9.66 TSG101
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.66 TSG101
5 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.66 DAG1 GTPBP1 TSG101
6 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.66 DAG1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.66 DAG1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-145 9.66 DAG1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-148 9.66 GTPBP1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.66 GTPBP1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.66 DAG1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.66 DAG1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.66 GTPBP1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-20 9.66 DAG1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.66 DAG1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.66 DAG1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.66 TSG101
18 Increased shRNA abundance (Z-score > 2) GR00366-A-48 9.66 GTPBP1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.66 TSG101
20 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.66 GTPBP1

MGI Mouse Phenotypes related to Argentine Hemorrhagic Fever:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.7 CLEC4G DAG1 DDX58 GP2 MBTPS1 PLAT
2 liver/biliary system MP:0005370 9.1 CLEC4G DDX58 MBTPS1 SERPINC1 SERPINE1 TFRC

Drugs & Therapeutics for Argentine Hemorrhagic Fever

Drugs for Argentine Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 2
2 Antibodies Phase 2
3 Pharmaceutical Solutions Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2, Randomized Clinical Trial to Evaluate the Efficacy and Safety of Human Anti-SARS-CoV-2 Convalescent Plasma in Severely Ill Adults With COVID-19 Recruiting NCT04359810 Phase 2
2 A Phase 2 Randomized, Double-blinded Trial to Evaluate the Efficacy and Safety of Human Anti- SARS-CoV-2 Plasma in Close Contacts of COVID-19 Cases Recruiting NCT04390503 Phase 2

Search NIH Clinical Center for Argentine Hemorrhagic Fever

Genetic Tests for Argentine Hemorrhagic Fever

Genetic tests related to Argentine Hemorrhagic Fever:

# Genetic test Affiliating Genes
1 Argentine Hemorrhagic Fever 29

Anatomical Context for Argentine Hemorrhagic Fever

MalaCards organs/tissues related to Argentine Hemorrhagic Fever:

40
Testes, Bone, Endothelial, Bone Marrow, Whole Blood, Spleen, Brain

Publications for Argentine Hemorrhagic Fever

Articles related to Argentine Hemorrhagic Fever:

(show top 50) (show all 218)
# Title Authors PMID Year
1
Clinical Management of Argentine Hemorrhagic Fever using Ribavirin and Favipiravir, Belgium, 2020. 61
32271701 2020
2
Type I interferon underlies severe disease associated with Junín virus infection in mice. 61
32452770 2020
3
The Glycoprotein of the Live-Attenuated Junin Virus Vaccine Strain Induces Endoplasmic Reticulum Stress and Forms Aggregates prior to Degradation in the Lysosome. 61
31996435 2020
4
Guinea Pig Transferrin Receptor 1 Mediates Cellular Entry of Junín Virus and Other Pathogenic New World Arenaviruses. 61
31748396 2020
5
Junín Virus Promotes Autophagy To Facilitate the Virus Life Cycle. 61
31118257 2019
6
Synthesis and antiviral activity of some imidazo[1,2-b][1,3,4]thiadiazole carbohydrate derivatives. 61
31176191 2019
7
Modified ribavirin analogues as antiviral agents against Junín virus. 61
30612844 2019
8
Infection of Rat Osteoblasts with Junin Virus Promotes the Expression of Bone Morphogenetic Protein 6, an Osteogenic Differentiation Inducer. 61
31121597 2019
9
Junin Virus Triggers Macrophage Activation and Modulates Polarization According to Viral Strain Pathogenicity. 61
31695702 2019
10
A potent Lassa virus antiviral targets an arenavirus virulence determinant. 61
30576397 2018
11
[Spatial difference in the incidence of Argentine Hemorrhagic Fever and composition and abundance of rodents in the assemblage]. 61
30534925 2018
12
Effective Population Size Differences in Calomys musculinus, the Host of Junín Virus: Their Relationship with the Epidemiological History of Argentine Hemorrhagic Fever. 61
29893205 2018
13
Antiviral activity of A771726, the active metabolite of leflunomide, against Junín virus. 61
29315647 2018
14
A Proteomics Survey of Junín Virus Interactions with Human Proteins Reveals Host Factors Required for Arenavirus Replication. 61
29187543 2018
15
Epistastic Interactions within the Junín Virus Envelope Glycoprotein Complex Provide an Evolutionary Barrier to Reversion in the Live-Attenuated Candid#1 Vaccine. 61
29070682 2018
16
Enhanced protection against experimental Junin virus infection through the use of a modified favipiravir loading dose strategy. 61
28780425 2017
17
Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization. 61
28630325 2017
18
[Stability of Candid#1 vaccine to prevent Argentine Hemorrhagic Fever]. 61
29044009 2017
19
Absence of an N-Linked Glycosylation Motif in the Glycoprotein of the Live-Attenuated Argentine Hemorrhagic Fever Vaccine, Candid #1, Results in Its Improper Processing, and Reduced Surface Expression. 61
28220142 2017
20
The Ectodomain of Glycoprotein from the Candid#1 Vaccine Strain of Junin Virus Rendered Machupo Virus Partially Attenuated in Mice Lacking IFN-αβ/γ Receptor. 61
27580122 2016
21
Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor. 61
26912630 2016
22
Monoclonal antibody therapy for Junin virus infection. 61
27044104 2016
23
Machupo Virus Expressing GPC of the Candid#1 Vaccine Strain of Junin Virus Is Highly Attenuated and Immunogenic. 61
26581982 2016
24
Low-dose ribavirin potentiates the antiviral activity of favipiravir against hemorrhagic fever viruses. 61
26711718 2016
25
[EXPERIENCE OF STUDY AND POSSIBLE WAYS OF ELIMINATION OF FALSE POSITIVE AND FALSE NEGATIVE RESULTS DURING EXECUTION OF POLYMERASE CHAIN REACTION ON AN EXAMPLE OF JUNIN VIRUS RNA DETECTION]. 61
26950993 2015
26
Novel Arenavirus Entry Inhibitors Discovered by Using a Minigenome Rescue System for High-Throughput Drug Screening. 61
26041296 2015
27
Human Plasmacytoid Dendritic Cells Elicited Different Responses after Infection with Pathogenic and Nonpathogenic Junin Virus Strains. 61
25926646 2015
28
The glycoprotein precursor gene of Junin virus determines the virulence of the Romero strain and the attenuation of the Candid #1 strain in a representative animal model of Argentine hemorrhagic fever. 61
25810546 2015
29
Favipiravir: a new medication for the Ebola virus disease pandemic. 61
25544306 2015
30
[New transmission scenarios of the Argentine hemorrhagic fever since the introduction of the live attenuated junin virus vaccine (Candid #1): an experience in migrant workers]. 61
26102120 2015
31
[Quali-quantitative study of the social variables defining transmission scenarios of Argentine Hemorrhagic Fever in the provinces of Buenos Aires and Santa Fe, 2001-2010]. 61
25237798 2014
32
Reactive astrogliosis in response to hemorrhagic fever virus: microarray profile of Junin virus-infected human astrocytes. 61
25015256 2014
33
[Study of sensitivity of laboratory animals to a causative agent of argentine hemorrhagic fever]. 61
25286529 2014
34
Toll-like receptor 2-mediated innate immune responses against Junín virus in mice lead to antiviral adaptive immune responses during systemic infection and do not affect viral replication in the brain. 61
24760892 2014
35
Potent inhibition of Junín virus infection by interferon in murine cells. 61
24901990 2014
36
Endothelial cell permeability and adherens junction disruption induced by junín virus infection. 61
24710609 2014
37
A host-oriented inhibitor of Junin Argentine hemorrhagic fever virus egress. 61
24522922 2014
38
RIG-I enhanced interferon independent apoptosis upon Junin virus infection. 61
24918927 2014
39
Watching every step of the way: junín virus attenuation markers in the vaccine lineage. 61
24396274 2013
40
[Optimization of conditions of quantitative evaluation of argentine hemorrhagic fever causative agent]. 61
23805673 2013
41
Favipiravir (T-705) inhibits Junín virus infection and reduces mortality in a guinea pig model of Argentine hemorrhagic fever. 61
24386500 2013
42
[Phenotypic markers of attenuation in Junin virus strains recently isolated from individuals vaccinated with Junin Candid#1 strain]. 61
23924527 2013
43
Vaccination strategies against highly pathogenic arenaviruses: the next steps toward clinical trials. 61
23592977 2013
44
Cleavage of the Junin virus nucleoprotein serves a decoy function to inhibit the induction of apoptosis during infection. 61
23077297 2013
45
Junín virus pathogenesis and virus replication. 61
23202466 2012
46
[Argentine hemorrhagic fever]. 61
22693817 2012
47
Junín virus infection activates the type I interferon pathway in a RIG-I-dependent manner. 61
22629479 2012
48
Progress in the experimental therapy of severe arenaviral infections. 61
22122440 2011
49
Substitutions in the glycoprotein (GP) of the Candid#1 vaccine strain of Junin virus increase dependence on human transferrin receptor 1 for entry and destabilize the metastable conformation of GP. 61
21976641 2011
50
Junin virus infects mouse cells and induces innate immune responses. 61
21880772 2011

Variations for Argentine Hemorrhagic Fever

Expression for Argentine Hemorrhagic Fever

Search GEO for disease gene expression data for Argentine Hemorrhagic Fever.

Pathways for Argentine Hemorrhagic Fever

Pathways related to Argentine Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.53 SERPINE1 SERPINC1 PLAT
2 11.29 SERPINE1 SERPINC1 PLAT
3 9.74 SERPINE1 PLAT

GO Terms for Argentine Hemorrhagic Fever

Cellular components related to Argentine Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.96 TSG101 TFRC SERPINE1 SERPINC1 RAB5C GP2
2 extracellular region GO:0005576 9.87 TFRC SERPINE1 SERPINC1 PLAT IFNA1 GP2
3 extracellular space GO:0005615 9.5 TFRC SERPINE1 SERPINC1 PLAT IFNA1 GP2
4 collagen-containing extracellular matrix GO:0062023 9.46 SERPINE1 SERPINC1 PLAT DAG1
5 extracellular exosome GO:0070062 9.23 TSG101 TFRC SERPINE1 SERPINC1 RAB5C PLAT

Biological processes related to Argentine Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.5 SERPINC1 PLAT IFNA1
2 response to exogenous dsRNA GO:0043330 9.37 IFNA1 DDX58
3 positive regulation of interleukin-8 production GO:0032757 9.26 SERPINE1 DDX58
4 fibrinolysis GO:0042730 9.16 SERPINE1 PLAT
5 viral entry into host cell GO:0046718 9.13 TFRC DAG1 CLEC4G
6 viral process GO:0016032 9.02 TSG101 TFRC DDX58 DAG1 CLEC4G

Molecular functions related to Argentine Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.8 TFRC DAG1 CLEC4G

Sources for Argentine Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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