MCID: ARG001
MIFTS: 35

Argentine Hemorrhagic Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Argentine Hemorrhagic Fever

MalaCards integrated aliases for Argentine Hemorrhagic Fever:

Name: Argentine Hemorrhagic Fever 12 77 60 15
Hemorrhagic Fever, Argentinian 74
Argentinian Hemorrhagic Fever 60
Junin Hemorrhagic Fever 60

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050194
ICD10 34 A96.0
ICD10 via Orphanet 35 A96.0
UMLS via Orphanet 75 C0019097
Orphanet 60 ORPHA319223
UMLS 74 C0019097

Summaries for Argentine Hemorrhagic Fever

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, has material basis in Junin virus, which is transmitted by rodent, Calomys musculinus. The infection has symptom fever, has symptom fatigue, has symptom malaise, has symptom leukopenia, has symptom thrombocytopenia, and has symptom hemorrhagic manifestations.

MalaCards based summary : Argentine Hemorrhagic Fever, also known as hemorrhagic fever, argentinian, is related to thrombophilia and aspirin allergy, and has symptoms including fever, fatigue and thrombocytopenia. An important gene associated with Argentine Hemorrhagic Fever is SERPINE1 (Serpin Family E Member 1), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Senescence and Autophagy in Cancer. Affiliated tissues include heart and testes.

Wikipedia : 77 Argentine hemorrhagic fever (AHF) or O''Higgins disease, also known in Argentina as mal de los rastrojos... more...

Related Diseases for Argentine Hemorrhagic Fever

Diseases related to Argentine Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 thrombophilia 10.3 SERPINC1 SERPINE1
2 aspirin allergy 10.2 SERPINC1 SERPINE1
3 sticky platelet syndrome 10.2 SERPINC1 SERPINE1
4 blue toe syndrome 10.2 SERPINC1 SERPINE1
5 ischemic colitis 10.2 SERPINC1 SERPINE1
6 subendocardial myocardial infarction 10.2 SERPINC1 SERPINE1
7 plasminogen activator inhibitor-1 deficiency 10.2 PLAT SERPINE1
8 central serous chorioretinopathy 10.2 PLAT SERPINE1
9 livedoid vasculitis 10.2 SERPINC1 SERPINE1
10 meningococcemia 10.2 SERPINC1 SERPINE1
11 post-thrombotic syndrome 10.2 SERPINC1 SERPINE1
12 carotid artery thrombosis 10.2 PLAT SERPINE1
13 intracranial embolism 10.2 PLAT SERPINC1
14 legg-calve-perthes disease 10.2 SERPINC1 SERPINE1
15 platelet aggregation, spontaneous 10.2 PLAT SERPINC1
16 retinal artery occlusion 10.2 SERPINC1 SERPINE1
17 acute cor pulmonale 10.2 PLAT SERPINE1
18 posterior myocardial infarction 10.2 PLAT SERPINC1
19 encephalopathy, familial, with neuroserpin inclusion bodies 10.2 PLAT SERPINC1
20 acute pulmonary heart disease 10.2 PLAT SERPINE1
21 portal vein thrombosis 10.2 SERPINC1 SERPINE1
22 hepatic vascular disease 10.2 SERPINC1 SERPINE1
23 marantic endocarditis 10.2 PLAT SERPINC1
24 endocarditis 10.2 PLAT SERPINC1
25 pleuropneumonia 10.2 PLAT SERPINC1
26 intermediate coronary syndrome 10.1 PLAT SERPINC1
27 epileptic encephalopathy, childhood-onset 10.1 SERPINC1 SERPINE1
28 chronic venous insufficiency 10.1 PLAT SERPINE1
29 venous insufficiency 10.1 PLAT SERPINE1
30 intracranial hypertension 10.1 SERPINC1 SERPINE1
31 pulmonary artery disease 10.1 PLAT SERPINC1
32 dysfibrinogenemia 10.1 PLAT SERPINC1
33 intermittent claudication 10.1 SERPINC1 SERPINE1
34 retinal vein occlusion 10.1 SERPINC1 SERPINE1
35 angina pectoris 10.1 PLAT SERPINC1
36 osteonecrosis 10.1 SERPINC1 SERPINE1
37 afibrinogenemia, congenital 10.0 PLAT SERPINC1
38 fibrinolytic defect 10.0 PLAT SERPINC1 SERPINE1
39 thrombophlebitis 10.0 PLAT SERPINC1 SERPINE1
40 coronary thrombosis 10.0 PLAT SERPINC1 SERPINE1
41 thrombosis 10.0 PLAT SERPINC1 SERPINE1
42 hepatic veno-occlusive disease 10.0 PLAT SERPINC1 SERPINE1
43 vein disease 10.0 PLAT SERPINC1 SERPINE1
44 thrombophilia due to activated protein c resistance 10.0 PLAT SERPINC1 SERPINE1
45 disseminated intravascular coagulation 10.0 PLAT SERPINC1 SERPINE1
46 thrombophilia due to thrombin defect 10.0 PLAT SERPINC1 SERPINE1
47 pulmonary embolism 10.0 PLAT SERPINC1 SERPINE1
48 peripheral vascular disease 10.0 PLAT SERPINC1 SERPINE1
49 vascular disease 10.0 PLAT SERPINC1 SERPINE1
50 arteries, anomalies of 10.0 PLAT SERPINC1 SERPINE1

Graphical network of the top 20 diseases related to Argentine Hemorrhagic Fever:



Diseases related to Argentine Hemorrhagic Fever

Symptoms & Phenotypes for Argentine Hemorrhagic Fever

Symptoms:

12
  • fever
  • fatigue
  • thrombocytopenia
  • leukopenia
  • malaise
  • hemorrhagic manifestations

Drugs & Therapeutics for Argentine Hemorrhagic Fever

Search Clinical Trials , NIH Clinical Center for Argentine Hemorrhagic Fever

Genetic Tests for Argentine Hemorrhagic Fever

Anatomical Context for Argentine Hemorrhagic Fever

MalaCards organs/tissues related to Argentine Hemorrhagic Fever:

42
Heart, Testes

Publications for Argentine Hemorrhagic Fever

Articles related to Argentine Hemorrhagic Fever:

(show top 50) (show all 73)
# Title Authors Year
1
Effective Population Size Differences in Calomys musculinus, the Host of Junín Virus: Their Relationship with the Epidemiological History of Argentine Hemorrhagic Fever. ( 29893205 )
2018
2
Absence of an N-Linked Glycosylation Motif in the Glycoprotein of the Live-Attenuated Argentine Hemorrhagic Fever Vaccine, Candid #1, Results in Its Improper Processing, and Reduced Surface Expression. ( 28220142 )
2017
3
Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization. ( 28630325 )
2017
4
The glycoprotein precursor gene of Junin virus determines the virulence of the Romero strain and the attenuation of the Candid #1 strain in a representative animal model of Argentine hemorrhagic fever. ( 25810546 )
2015
5
A host-oriented inhibitor of Junin Argentine hemorrhagic fever virus egress. ( 24522922 )
2014
6
Favipiravir (T-705) inhibits Junín virus infection and reduces mortality in a guinea pig model of Argentine hemorrhagic fever. ( 24386500 )
2013
7
Imidazo[2,1-b]thiazole carbohydrate derivatives: Synthesis and antiviral activity against Junin virus, agent of Argentine hemorrhagic fever. ( 21115214 )
2011
8
Rescue from cloned cDNAs and in vivo characterization of recombinant pathogenic Romero and live-attenuated Candid #1 strains of Junin virus, the causative agent of Argentine hemorrhagic fever disease. ( 21123388 )
2011
9
Argentine hemorrhagic fever vaccines. ( 21451263 )
2011
10
The major determinant of attenuation in mice of the Candid1 vaccine for Argentine hemorrhagic fever is located in the G2 glycoprotein transmembrane domain. ( 21795336 )
2011
11
Treatment of Argentine hemorrhagic fever. ( 18054395 )
2008
12
Argentine hemorrhagic fever diagnostic test based on recombinant Junín virus N protein. ( 19040289 )
2008
13
Immune response to vaccination against Argentine hemorrhagic Fever in an area where different arenaviruses coexist. ( 16817762 )
2006
14
Inhibition of cell fusion in Junin virus-infected cells by sera from Argentine hemorrhagic fever patients. ( 15780806 )
2005
15
Inheritance of random amplified polymorphic DNA (RAPD-PCR) markers and their use in population genetic studies of Calomys musculinus (Rodentia, Muridae), the reservoir of Argentine hemorrhagic fever. ( 12035619 )
2001
16
Relationship between hematopoietic growth factors levels and hematological parameters in Argentine hemorrhagic fever. ( 10815780 )
2000
17
Proinflammatory cytokines and elastase-alpha-1-antitrypsin in Argentine hemorrhagic fever. ( 9988328 )
1999
18
Clinical case definitions for Argentine hemorrhagic fever. ( 10452640 )
1999
19
Protective efficacy of a live attenuated vaccine against Argentine hemorrhagic fever. AHF Study Group. ( 9466512 )
1998
20
Rapid diagnosis of Argentine hemorrhagic fever by reverse transcriptase PCR-based assay. ( 7542268 )
1995
21
Early markers of blood coagulation and fibrinolysis activation in Argentine hemorrhagic fever. ( 7667817 )
1995
22
Prevalence of infection with Junin virus in rodent populations in the epidemic area of Argentine hemorrhagic fever. ( 7985747 )
1994
23
Antiviral treatment of Argentine hemorrhagic fever. ( 8141590 )
1994
24
Further studies on the plasma inhibitor of platelet activation in Argentine hemorrhagic fever. ( 8322277 )
1993
25
Safety and immunogenicity of a live-attenuated Junin (Argentine hemorrhagic fever) vaccine in rhesus macaques. ( 8385886 )
1993
26
Peripheral blood leukocytes of patients with Argentine hemorrhagic fever as effectors of antibody-dependent cell-cytotoxicity. ( 1331313 )
1992
27
A longitudinal study of Junin virus activity in the rodent reservoir of Argentine hemorrhagic fever. ( 1335214 )
1992
28
Candid No. 1 Argentine hemorrhagic fever vaccine protects against lethal Junin virus challenge in rhesus macaques. ( 1338783 )
1992
29
Increased tumor necrosis factor-alpha levels in Argentine hemorrhagic fever. ( 1402041 )
1992
30
Toward a vaccine against Argentine hemorrhagic fever. ( 1654168 )
1991
31
Activity of a platelet protein kinase that phosphorylates fibrinogen and histone in Argentine hemorrhagic fever. ( 1726921 )
1991
32
Protection of guinea pigs against experimental Argentine hemorrhagic fever by purified human IgG: importance of elimination of infected cells. ( 1965845 )
1990
33
A plasma inhibitor of platelet aggregation in patients with Argentine hemorrhagic fever. ( 2160197 )
1990
34
Hemostasis and the complement system in Argentine hemorrhagic fever. ( 2665012 )
1989
35
Lymphocyte subsets alteration in patients with argentine hemorrhagic fever. ( 2921602 )
1989
36
Relation of endogenous interferon and high levels of 2'-5' oligoadenylate synthetase in leukocytes from patients with Argentine hemorrhagic fever. ( 3361147 )
1988
37
Ribavirin prophylaxis and therapy for experimental argentine hemorrhagic fever. ( 2848441 )
1988
38
Viral strain dependent differences in experimental Argentine hemorrhagic fever (Junin virus) infection of guinea pigs. ( 2846464 )
1988
39
Epidemiology of Argentine hemorrhagic fever. ( 2841151 )
1988
40
Long-term protection against Argentine hemorrhagic fever in Tacaribe virus infected marmosets: virologic and histopathologic findings. ( 2832541 )
1988
41
Tolerance and antiviral effect of ribavirin in patients with Argentine hemorrhagic fever. ( 2445283 )
1987
42
Plasminogen abnormalities in patients with Argentine hemorrhagic fever. ( 2448897 )
1987
43
Tacaribe virus: a new alternative for Argentine hemorrhagic fever vaccine. ( 2828522 )
1987
44
Effect of polymorphonuclear depletion on experimental Argentine hemorrhagic fever in guinea pigs. ( 3040897 )
1987
45
Virus-specific factors in experimental Argentine hemorrhagic fever in rhesus macaques. ( 3039054 )
1987
46
Experimental Argentine hemorrhagic fever in rhesus macaques: virus-specific variations in pathology. ( 3039051 )
1987
47
Argentine hemorrhagic fever. ( 3034513 )
1987
48
Experimental Argentine hemorrhagic fever: myocardial involvement in Cebus monkey. ( 3025446 )
1986
49
Current status of the treatment of Argentine Hemorrhagic Fever. ( 3014290 )
1986
50
Progressive extension of the endemic area and changing incidence of Argentine Hemorrhagic Fever. ( 3014288 )
1986

Variations for Argentine Hemorrhagic Fever

Expression for Argentine Hemorrhagic Fever

Search GEO for disease gene expression data for Argentine Hemorrhagic Fever.

Pathways for Argentine Hemorrhagic Fever

GO Terms for Argentine Hemorrhagic Fever

Cellular components related to Argentine Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.55 GP2 IMPDH2 PLAT SERPINC1 SERPINE1
2 extracellular exosome GO:0070062 9.35 GP2 IMPDH2 PLAT SERPINC1 SERPINE1
3 collagen-containing extracellular matrix GO:0062023 8.8 PLAT SERPINC1 SERPINE1

Biological processes related to Argentine Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 circadian rhythm GO:0007623 9.16 IMPDH2 SERPINE1
2 positive regulation of interleukin-8 production GO:0032757 8.96 DDX58 SERPINE1
3 fibrinolysis GO:0042730 8.62 PLAT SERPINE1

Molecular functions related to Argentine Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.96 SERPINC1 SERPINE1
2 serine-type endopeptidase inhibitor activity GO:0004867 8.62 SERPINC1 SERPINE1

Sources for Argentine Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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