MCID: ARG001
MIFTS: 34

Argentine Hemorrhagic Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Argentine Hemorrhagic Fever

MalaCards integrated aliases for Argentine Hemorrhagic Fever:

Name: Argentine Hemorrhagic Fever 12 75 59 15
Hemorrhagic Fever, Argentinian 72
Argentinian Hemorrhagic Fever 59
Junin Hemorrhagic Fever 59

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050194
ICD10 33 A96.0
ICD10 via Orphanet 34 A96.0
UMLS via Orphanet 73 C0019097
Orphanet 59 ORPHA319223
UMLS 72 C0019097

Summaries for Argentine Hemorrhagic Fever

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, has material basis in Junin virus, which is transmitted by rodent, Calomys musculinus. The infection has symptom fever, has symptom fatigue, has symptom malaise, has symptom leukopenia, has symptom thrombocytopenia, and has symptom hemorrhagic manifestations.

MalaCards based summary : Argentine Hemorrhagic Fever, also known as hemorrhagic fever, argentinian, is related to disseminated intravascular coagulation and hemorrhagic disease, and has symptoms including fever, fatigue and thrombocytopenia. An important gene associated with Argentine Hemorrhagic Fever is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Senescence and Autophagy in Cancer. Affiliated tissues include testes, bone and endothelial.

Wikipedia : 75 Argentine hemorrhagic fever (AHF) or O'Higgins disease, also known in Argentina as mal de los rastrojos... more...

Related Diseases for Argentine Hemorrhagic Fever

Diseases related to Argentine Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 disseminated intravascular coagulation 30.0 SERPINE1 SERPINC1 PLAT
2 hemorrhagic disease 30.0 SERPINE1 SERPINC1 PLAT
3 intracranial embolism 10.4 SERPINC1 PLAT
4 platelet aggregation, spontaneous 10.4 SERPINC1 PLAT
5 posterior myocardial infarction 10.4 SERPINC1 PLAT
6 encephalopathy, familial, with neuroserpin inclusion bodies 10.4 SERPINC1 PLAT
7 marantic endocarditis 10.4 SERPINC1 PLAT
8 plasminogen activator inhibitor-1 deficiency 10.4 SERPINE1 PLAT
9 endocarditis 10.4 SERPINC1 PLAT
10 central serous chorioretinopathy 10.4 SERPINE1 PLAT
11 thrombophilia 10.4 SERPINE1 SERPINC1
12 sticky platelet syndrome 10.3 SERPINE1 SERPINC1
13 pleuropneumonia 10.3 SERPINC1 PLAT
14 carotid artery thrombosis 10.3 SERPINE1 PLAT
15 aspirin allergy 10.3 SERPINE1 SERPINC1
16 intermediate coronary syndrome 10.3 SERPINC1 PLAT
17 blue toe syndrome 10.3 SERPINE1 SERPINC1
18 acute cor pulmonale 10.3 SERPINE1 PLAT
19 ischemic colitis 10.3 SERPINE1 SERPINC1
20 subendocardial myocardial infarction 10.3 SERPINE1 SERPINC1
21 acute pulmonary heart disease 10.3 SERPINE1 PLAT
22 dysfibrinogenemia 10.3 SERPINC1 PLAT
23 pulmonary artery disease 10.3 SERPINC1 PLAT
24 livedoid vasculitis 10.3 SERPINE1 SERPINC1
25 meningococcemia 10.3 SERPINE1 SERPINC1
26 post-thrombotic syndrome 10.3 SERPINE1 SERPINC1
27 lymphocytic choriomeningitis 10.2
28 neutropenia 10.2
29 thrombocytopenia 10.2
30 angina pectoris 10.2 SERPINC1 PLAT
31 retinal artery occlusion 10.2 SERPINE1 SERPINC1
32 legg-calve-perthes disease 10.2 SERPINE1 SERPINC1
33 portal vein thrombosis 10.2 SERPINE1 SERPINC1
34 chronic venous insufficiency 10.2 SERPINE1 PLAT
35 venous insufficiency 10.2 SERPINE1 PLAT
36 hepatic vascular disease 10.2 SERPINE1 SERPINC1
37 epileptic encephalopathy, childhood-onset 10.1 SERPINE1 SERPINC1
38 afibrinogenemia, congenital 10.1 SERPINC1 PLAT
39 intracranial hypertension 10.1 SERPINE1 SERPINC1
40 retinal vein occlusion 10.1 SERPINE1 SERPINC1
41 intermittent claudication 10.1 SERPINE1 SERPINC1
42 antiphospholipid syndrome 10.1 SERPINC1 PLAT
43 bolivian hemorrhagic fever 10.0
44 hypotonia 10.0
45 osteonecrosis 10.0 SERPINE1 SERPINC1
46 fibrinolytic defect 10.0 SERPINE1 SERPINC1 PLAT
47 thrombophlebitis 10.0 SERPINE1 SERPINC1 PLAT
48 coronary thrombosis 10.0 SERPINE1 SERPINC1 PLAT
49 thrombosis 10.0 SERPINE1 SERPINC1 PLAT
50 hepatic veno-occlusive disease 10.0 SERPINE1 SERPINC1 PLAT

Graphical network of the top 20 diseases related to Argentine Hemorrhagic Fever:



Diseases related to Argentine Hemorrhagic Fever

Symptoms & Phenotypes for Argentine Hemorrhagic Fever

Symptoms:

12
  • fever
  • fatigue
  • thrombocytopenia
  • leukopenia
  • malaise
  • hemorrhagic manifestations

Drugs & Therapeutics for Argentine Hemorrhagic Fever

Search Clinical Trials , NIH Clinical Center for Argentine Hemorrhagic Fever

Genetic Tests for Argentine Hemorrhagic Fever

Anatomical Context for Argentine Hemorrhagic Fever

MalaCards organs/tissues related to Argentine Hemorrhagic Fever:

41
Testes, Bone, Endothelial, Bone Marrow, Brain, Spleen, Whole Blood

Publications for Argentine Hemorrhagic Fever

Articles related to Argentine Hemorrhagic Fever:

(show top 50) (show all 213)
# Title Authors PMID Year
1
Junín Virus Promotes Autophagy To Facilitate the Virus Life Cycle. 38
31118257 2019
2
Synthesis and antiviral activity of some imidazo[1,2-b][1,3,4]thiadiazole carbohydrate derivatives. 38
31176191 2019
3
Modified ribavirin analogues as antiviral agents against Junín virus. 38
30612844 2019
4
Infection of Rat Osteoblasts with Junin Virus Promotes the Expression of Bone Morphogenetic Protein 6, an Osteogenic Differentiation Inducer. 38
31121597 2019
5
A potent Lassa virus antiviral targets an arenavirus virulence determinant. 38
30576397 2018
6
[Spatial difference in the incidence of Argentine Hemorrhagic Fever and composition and abundance of rodents in the assemblage]. 38
30534925 2018
7
Effective Population Size Differences in Calomys musculinus, the Host of Junín Virus: Their Relationship with the Epidemiological History of Argentine Hemorrhagic Fever. 38
29893205 2018
8
Antiviral activity of A771726, the active metabolite of leflunomide, against Junín virus. 38
29315647 2018
9
A Proteomics Survey of Junín Virus Interactions with Human Proteins Reveals Host Factors Required for Arenavirus Replication. 38
29187543 2018
10
Epistastic Interactions within the Junín Virus Envelope Glycoprotein Complex Provide an Evolutionary Barrier to Reversion in the Live-Attenuated Candid#1 Vaccine. 38
29070682 2018
11
Enhanced protection against experimental Junin virus infection through the use of a modified favipiravir loading dose strategy. 38
28780425 2017
12
Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization. 38
28630325 2017
13
[Stability of Candid#1 vaccine to prevent Argentine Hemorrhagic Fever]. 38
29044009 2017
14
Absence of an N-Linked Glycosylation Motif in the Glycoprotein of the Live-Attenuated Argentine Hemorrhagic Fever Vaccine, Candid #1, Results in Its Improper Processing, and Reduced Surface Expression. 38
28220142 2017
15
The Ectodomain of Glycoprotein from the Candid#1 Vaccine Strain of Junin Virus Rendered Machupo Virus Partially Attenuated in Mice Lacking IFN-αβ/γ Receptor. 38
27580122 2016
16
Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor. 38
26912630 2016
17
Monoclonal antibody therapy for Junin virus infection. 38
27044104 2016
18
Machupo Virus Expressing GPC of the Candid#1 Vaccine Strain of Junin Virus Is Highly Attenuated and Immunogenic. 38
26581982 2016
19
Low-dose ribavirin potentiates the antiviral activity of favipiravir against hemorrhagic fever viruses. 38
26711718 2016
20
[EXPERIENCE OF STUDY AND POSSIBLE WAYS OF ELIMINATION OF FALSE POSITIVE AND FALSE NEGATIVE RESULTS DURING EXECUTION OF POLYMERASE CHAIN REACTION ON AN EXAMPLE OF JUNIN VIRUS RNA DETECTION]. 38
26950993 2015
21
Novel Arenavirus Entry Inhibitors Discovered by Using a Minigenome Rescue System for High-Throughput Drug Screening. 38
26041296 2015
22
Human Plasmacytoid Dendritic Cells Elicited Different Responses after Infection with Pathogenic and Nonpathogenic Junin Virus Strains. 38
25926646 2015
23
The glycoprotein precursor gene of Junin virus determines the virulence of the Romero strain and the attenuation of the Candid #1 strain in a representative animal model of Argentine hemorrhagic fever. 38
25810546 2015
24
Favipiravir: a new medication for the Ebola virus disease pandemic. 38
25544306 2015
25
[New transmission scenarios of the Argentine hemorrhagic fever since the introduction of the live attenuated junin virus vaccine (Candid #1): an experience in migrant workers]. 38
26102120 2015
26
[Quali-quantitative study of the social variables defining transmission scenarios of Argentine Hemorrhagic Fever in the provinces of Buenos Aires and Santa Fe, 2001-2010]. 38
25237798 2014
27
Reactive astrogliosis in response to hemorrhagic fever virus: microarray profile of Junin virus-infected human astrocytes. 38
25015256 2014
28
[Study of sensitivity of laboratory animals to a causative agent of argentine hemorrhagic fever]. 38
25286529 2014
29
Toll-like receptor 2-mediated innate immune responses against Junín virus in mice lead to antiviral adaptive immune responses during systemic infection and do not affect viral replication in the brain. 38
24760892 2014
30
Endothelial cell permeability and adherens junction disruption induced by junín virus infection. 38
24710609 2014
31
Potent inhibition of Junín virus infection by interferon in murine cells. 38
24901990 2014
32
A host-oriented inhibitor of Junin Argentine hemorrhagic fever virus egress. 38
24522922 2014
33
RIG-I enhanced interferon independent apoptosis upon Junin virus infection. 38
24918927 2014
34
Watching every step of the way: junín virus attenuation markers in the vaccine lineage. 38
24396274 2013
35
[Optimization of conditions of quantitative evaluation of argentine hemorrhagic fever causative agent]. 38
23805673 2013
36
Favipiravir (T-705) inhibits Junín virus infection and reduces mortality in a guinea pig model of Argentine hemorrhagic fever. 38
24386500 2013
37
Vaccination strategies against highly pathogenic arenaviruses: the next steps toward clinical trials. 38
23592977 2013
38
[Phenotypic markers of attenuation in Junin virus strains recently isolated from individuals vaccinated with Junin Candid#1 strain]. 38
23924527 2013
39
Cleavage of the Junin virus nucleoprotein serves a decoy function to inhibit the induction of apoptosis during infection. 38
23077297 2013
40
Junín virus pathogenesis and virus replication. 38
23202466 2012
41
[Argentine hemorrhagic fever]. 38
22693817 2012
42
Junín virus infection activates the type I interferon pathway in a RIG-I-dependent manner. 38
22629479 2012
43
Progress in the experimental therapy of severe arenaviral infections. 38
22122440 2011
44
Substitutions in the glycoprotein (GP) of the Candid#1 vaccine strain of Junin virus increase dependence on human transferrin receptor 1 for entry and destabilize the metastable conformation of GP. 38
21976641 2011
45
Junin virus infects mouse cells and induces innate immune responses. 38
21880772 2011
46
Effective oral favipiravir (T-705) therapy initiated after the onset of clinical disease in a model of arenavirus hemorrhagic Fever. 38
22022624 2011
47
The major determinant of attenuation in mice of the Candid1 vaccine for Argentine hemorrhagic fever is located in the G2 glycoprotein transmembrane domain. 38
21795336 2011
48
Viral diversity of Junín virus field strains. 38
21689697 2011
49
Argentine hemorrhagic fever vaccines. 38
21451263 2011
50
Junín virus. A XXI century update. 38
21238601 2011

Variations for Argentine Hemorrhagic Fever

Expression for Argentine Hemorrhagic Fever

Search GEO for disease gene expression data for Argentine Hemorrhagic Fever.

Pathways for Argentine Hemorrhagic Fever

GO Terms for Argentine Hemorrhagic Fever

Cellular components related to Argentine Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.55 SERPINE1 SERPINC1 PLAT IMPDH2 GP2
2 extracellular exosome GO:0070062 9.35 SERPINE1 SERPINC1 PLAT IMPDH2 GP2
3 collagen-containing extracellular matrix GO:0062023 8.8 SERPINE1 SERPINC1 PLAT

Biological processes related to Argentine Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 circadian rhythm GO:0007623 9.16 SERPINE1 IMPDH2
2 positive regulation of interleukin-8 production GO:0032757 8.96 SERPINE1 DDX58
3 fibrinolysis GO:0042730 8.62 SERPINE1 PLAT

Molecular functions related to Argentine Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.96 SERPINE1 SERPINC1
2 serine-type endopeptidase inhibitor activity GO:0004867 8.62 SERPINE1 SERPINC1

Sources for Argentine Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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