MCID: ARG001
MIFTS: 36

Argentine Hemorrhagic Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Argentine Hemorrhagic Fever

MalaCards integrated aliases for Argentine Hemorrhagic Fever:

Name: Argentine Hemorrhagic Fever 12 74 58 15
Hemorrhagic Fever, Argentinian 71
Argentinian Hemorrhagic Fever 58
Junin Hemorrhagic Fever 58

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050194
ICD10 32 A96.0
ICD10 via Orphanet 33 A96.0
UMLS via Orphanet 72 C0019097
Orphanet 58 ORPHA319223
UMLS 71 C0019097

Summaries for Argentine Hemorrhagic Fever

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, has material basis in Junin virus, which is transmitted by rodent, Calomys musculinus. The infection has symptom fever, has symptom fatigue, has symptom malaise, has symptom leukopenia, has symptom thrombocytopenia, and has symptom hemorrhagic manifestations.

MalaCards based summary : Argentine Hemorrhagic Fever, also known as hemorrhagic fever, argentinian, is related to hemorrhagic disease and disseminated intravascular coagulation, and has symptoms including fatigue, fever and thrombocytopenia. An important gene associated with Argentine Hemorrhagic Fever is TSG101 (Tumor Susceptibility 101), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. Affiliated tissues include bone, bone marrow and testes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 74 Argentine hemorrhagic fever (AHF) or O'Higgins disease, also known in Argentina as mal de los rastrojos... more...

Related Diseases for Argentine Hemorrhagic Fever

Diseases related to Argentine Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 hemorrhagic disease 30.3 SERPINE1 SERPINC1 PLAT
2 disseminated intravascular coagulation 30.3 SERPINE1 SERPINC1 PLAT
3 thrombocytopenia 30.1 TFRC SERPINE1 SERPINC1 PLAT
4 lymphocytic choriomeningitis 29.4 IRF3 DDX58 CLEC4G
5 bolivian hemorrhagic fever 28.1 TSG101 TFRC MBTPS1 IRF3 GTPBP1 GP2
6 lassa fever 27.3 TSG101 MBTPS1 IRF3 GTPBP1 GP2 ERVW-1
7 cardiac tuberculosis 10.4 SERPINE1 SERPINC1
8 sticky platelet syndrome 10.4 SERPINE1 SERPINC1
9 dic in newborn 10.4 SERPINE1 SERPINC1
10 central serous chorioretinopathy 10.4 SERPINE1 PLAT
11 plasminogen activator inhibitor-1 deficiency 10.4 SERPINE1 PLAT
12 livedoid vasculitis 10.4 SERPINE1 SERPINC1
13 platelet aggregation, spontaneous 10.4 SERPINC1 PLAT
14 meningococcemia 10.4 SERPINE1 SERPINC1
15 marantic endocarditis 10.4 SERPINC1 PLAT
16 thoracic outlet syndrome 10.3 SERPINC1 PLAT
17 intracranial embolism 10.3 SERPINC1 PLAT
18 central retinal artery occlusion 10.3 SERPINC1 PLAT
19 encephalopathy, familial, with neuroserpin inclusion bodies 10.3 SERPINC1 PLAT
20 coronary restenosis 10.3 SERPINC1 PLAT
21 intracranial thrombosis 10.3 SERPINC1 PLAT
22 ischemic colitis 10.3 SERPINE1 SERPINC1
23 factor xiii deficiency 10.2 SERPINE1 SERPINC1
24 dysfibrinogenemia, congenital 10.2 SERPINC1 PLAT
25 neutropenia 10.2
26 fibrinolytic defect 10.2 SERPINE1 SERPINC1 PLAT
27 legg-calve-perthes disease 10.2 SERPINE1 SERPINC1
28 carotid artery thrombosis 10.2 SERPINE1 SERPINC1 PLAT
29 post-thrombotic syndrome 10.2 SERPINE1 SERPINC1 PLAT
30 thrombophilia due to activated protein c resistance 10.2 SERPINE1 SERPINC1 PLAT
31 thrombophilia 10.2 SERPINE1 SERPINC1 PLAT
32 thrombophlebitis 10.2 SERPINE1 SERPINC1 PLAT
33 coronary thrombosis 10.2 SERPINE1 SERPINC1 PLAT
34 pulmonary artery disease 10.2 SERPINE1 SERPINC1 PLAT
35 portal vein thrombosis 10.2 SERPINE1 SERPINC1 PLAT
36 hepatic veno-occlusive disease 10.2 SERPINE1 SERPINC1 PLAT
37 thrombophilia due to thrombin defect 10.2 SERPINE1 SERPINC1 PLAT
38 vein disease 10.2 SERPINE1 SERPINC1 PLAT
39 afibrinogenemia, congenital 10.2 SERPINE1 SERPINC1 PLAT
40 antiphospholipid syndrome 10.2 SERPINE1 SERPINC1 PLAT
41 endocarditis 10.2 SERPINE1 SERPINC1 PLAT
42 pulmonary embolism 10.2 SERPINE1 SERPINC1 PLAT
43 peripheral vascular disease 10.1 SERPINE1 SERPINC1 PLAT
44 patent foramen ovale 10.1 SERPINE1 SERPINC1 PLAT
45 central retinal vein occlusion 10.1 SERPINC1 PLAT
46 venezuelan hemorrhagic fever 10.1 MBTPS1 GTPBP1 GP2
47 swine influenza 10.1 GP2 DDX58
48 ebola hemorrhagic fever 10.1 GTPBP1 GP2 ERVW-1
49 hypotonia 10.0
50 bacterial infectious disease 10.0

Graphical network of the top 20 diseases related to Argentine Hemorrhagic Fever:



Diseases related to Argentine Hemorrhagic Fever

Symptoms & Phenotypes for Argentine Hemorrhagic Fever

Symptoms:

12
  • fatigue
  • fever
  • thrombocytopenia
  • leukopenia
  • malaise
  • hemorrhagic manifestations

MGI Mouse Phenotypes related to Argentine Hemorrhagic Fever:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 CLEC4G DDX58 IRF3 MBTPS1 PLAT RAB5C
2 homeostasis/metabolism MP:0005376 9.65 CLEC4G DDX58 IRF3 MBTPS1 PLAT RAB5C
3 liver/biliary system MP:0005370 9.1 CLEC4G DDX58 MBTPS1 SERPINC1 SERPINE1 TFRC

Drugs & Therapeutics for Argentine Hemorrhagic Fever

Search Clinical Trials , NIH Clinical Center for Argentine Hemorrhagic Fever

Genetic Tests for Argentine Hemorrhagic Fever

Anatomical Context for Argentine Hemorrhagic Fever

MalaCards organs/tissues related to Argentine Hemorrhagic Fever:

40
Bone, Bone Marrow, Testes, Endothelial, Whole Blood, Spleen, Brain

Publications for Argentine Hemorrhagic Fever

Articles related to Argentine Hemorrhagic Fever:

(show top 50) (show all 216)
# Title Authors PMID Year
1
The glycoprotein of the live-attenuated Junin virus vaccine strain induces ER stress and forms aggregates prior to degradation in the lysosome. 61
31996435 2020
2
Guinea Pig Transferrin Receptor 1 Mediates Cellular Entry of Junín Virus and Other Pathogenic New World Arenaviruses. 61
31748396 2020
3
Junín Virus Promotes Autophagy To Facilitate the Virus Life Cycle. 61
31118257 2019
4
Synthesis and antiviral activity of some imidazo[1,2-b][1,3,4]thiadiazole carbohydrate derivatives. 61
31176191 2019
5
Modified ribavirin analogues as antiviral agents against Junín virus. 61
30612844 2019
6
Infection of Rat Osteoblasts with Junin Virus Promotes the Expression of Bone Morphogenetic Protein 6, an Osteogenic Differentiation Inducer. 61
31121597 2019
7
Junin Virus Triggers Macrophage Activation and Modulates Polarization According to Viral Strain Pathogenicity. 61
31695702 2019
8
A potent Lassa virus antiviral targets an arenavirus virulence determinant. 61
30576397 2018
9
[Spatial difference in the incidence of Argentine Hemorrhagic Fever and composition and abundance of rodents in the assemblage]. 61
30534925 2018
10
Effective Population Size Differences in Calomys musculinus, the Host of Junín Virus: Their Relationship with the Epidemiological History of Argentine Hemorrhagic Fever. 61
29893205 2018
11
Antiviral activity of A771726, the active metabolite of leflunomide, against Junín virus. 61
29315647 2018
12
A Proteomics Survey of Junín Virus Interactions with Human Proteins Reveals Host Factors Required for Arenavirus Replication. 61
29187543 2018
13
Epistastic Interactions within the Junín Virus Envelope Glycoprotein Complex Provide an Evolutionary Barrier to Reversion in the Live-Attenuated Candid#1 Vaccine. 61
29070682 2018
14
Enhanced protection against experimental Junin virus infection through the use of a modified favipiravir loading dose strategy. 61
28780425 2017
15
Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization. 61
28630325 2017
16
[Stability of Candid#1 vaccine to prevent Argentine Hemorrhagic Fever]. 61
29044009 2017
17
Absence of an N-Linked Glycosylation Motif in the Glycoprotein of the Live-Attenuated Argentine Hemorrhagic Fever Vaccine, Candid #1, Results in Its Improper Processing, and Reduced Surface Expression. 61
28220142 2017
18
The Ectodomain of Glycoprotein from the Candid#1 Vaccine Strain of Junin Virus Rendered Machupo Virus Partially Attenuated in Mice Lacking IFN-αβ/γ Receptor. 61
27580122 2016
19
Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor. 61
26912630 2016
20
Monoclonal antibody therapy for Junin virus infection. 61
27044104 2016
21
Machupo Virus Expressing GPC of the Candid#1 Vaccine Strain of Junin Virus Is Highly Attenuated and Immunogenic. 61
26581982 2016
22
Low-dose ribavirin potentiates the antiviral activity of favipiravir against hemorrhagic fever viruses. 61
26711718 2016
23
[EXPERIENCE OF STUDY AND POSSIBLE WAYS OF ELIMINATION OF FALSE POSITIVE AND FALSE NEGATIVE RESULTS DURING EXECUTION OF POLYMERASE CHAIN REACTION ON AN EXAMPLE OF JUNIN VIRUS RNA DETECTION]. 61
26950993 2015
24
Novel Arenavirus Entry Inhibitors Discovered by Using a Minigenome Rescue System for High-Throughput Drug Screening. 61
26041296 2015
25
Human Plasmacytoid Dendritic Cells Elicited Different Responses after Infection with Pathogenic and Nonpathogenic Junin Virus Strains. 61
25926646 2015
26
The glycoprotein precursor gene of Junin virus determines the virulence of the Romero strain and the attenuation of the Candid #1 strain in a representative animal model of Argentine hemorrhagic fever. 61
25810546 2015
27
Favipiravir: a new medication for the Ebola virus disease pandemic. 61
25544306 2015
28
[New transmission scenarios of the Argentine hemorrhagic fever since the introduction of the live attenuated junin virus vaccine (Candid #1): an experience in migrant workers]. 61
26102120 2015
29
[Quali-quantitative study of the social variables defining transmission scenarios of Argentine Hemorrhagic Fever in the provinces of Buenos Aires and Santa Fe, 2001-2010]. 61
25237798 2014
30
Reactive astrogliosis in response to hemorrhagic fever virus: microarray profile of Junin virus-infected human astrocytes. 61
25015256 2014
31
[Study of sensitivity of laboratory animals to a causative agent of argentine hemorrhagic fever]. 61
25286529 2014
32
Toll-like receptor 2-mediated innate immune responses against Junín virus in mice lead to antiviral adaptive immune responses during systemic infection and do not affect viral replication in the brain. 61
24760892 2014
33
Endothelial cell permeability and adherens junction disruption induced by junín virus infection. 61
24710609 2014
34
Potent inhibition of Junín virus infection by interferon in murine cells. 61
24901990 2014
35
A host-oriented inhibitor of Junin Argentine hemorrhagic fever virus egress. 61
24522922 2014
36
RIG-I enhanced interferon independent apoptosis upon Junin virus infection. 61
24918927 2014
37
Watching every step of the way: junín virus attenuation markers in the vaccine lineage. 61
24396274 2013
38
[Optimization of conditions of quantitative evaluation of argentine hemorrhagic fever causative agent]. 61
23805673 2013
39
Favipiravir (T-705) inhibits Junín virus infection and reduces mortality in a guinea pig model of Argentine hemorrhagic fever. 61
24386500 2013
40
[Phenotypic markers of attenuation in Junin virus strains recently isolated from individuals vaccinated with Junin Candid#1 strain]. 61
23924527 2013
41
Vaccination strategies against highly pathogenic arenaviruses: the next steps toward clinical trials. 61
23592977 2013
42
Cleavage of the Junin virus nucleoprotein serves a decoy function to inhibit the induction of apoptosis during infection. 61
23077297 2013
43
Junín virus pathogenesis and virus replication. 61
23202466 2012
44
[Argentine hemorrhagic fever]. 61
22693817 2012
45
Junín virus infection activates the type I interferon pathway in a RIG-I-dependent manner. 61
22629479 2012
46
Progress in the experimental therapy of severe arenaviral infections. 61
22122440 2011
47
Substitutions in the glycoprotein (GP) of the Candid#1 vaccine strain of Junin virus increase dependence on human transferrin receptor 1 for entry and destabilize the metastable conformation of GP. 61
21976641 2011
48
Junin virus infects mouse cells and induces innate immune responses. 61
21880772 2011
49
Effective oral favipiravir (T-705) therapy initiated after the onset of clinical disease in a model of arenavirus hemorrhagic Fever. 61
22022624 2011
50
The major determinant of attenuation in mice of the Candid1 vaccine for Argentine hemorrhagic fever is located in the G2 glycoprotein transmembrane domain. 61
21795336 2011

Variations for Argentine Hemorrhagic Fever

Expression for Argentine Hemorrhagic Fever

Search GEO for disease gene expression data for Argentine Hemorrhagic Fever.

Pathways for Argentine Hemorrhagic Fever

GO Terms for Argentine Hemorrhagic Fever

Cellular components related to Argentine Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.17 TSG101 TFRC SERPINE1 SERPINC1 RAB5C PLAT

Biological processes related to Argentine Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to exogenous dsRNA GO:0043330 9.43 IRF3 DDX58
2 negative regulation of type I interferon production GO:0032480 9.4 IRF3 DDX58
3 positive regulation of interleukin-8 production GO:0032757 9.37 SERPINE1 DDX58
4 positive regulation of interferon-beta production GO:0032728 9.32 IRF3 DDX58
5 fibrinolysis GO:0042730 9.26 SERPINE1 PLAT
6 cellular response to exogenous dsRNA GO:0071360 9.16 IRF3 DDX58
7 viral process GO:0016032 9.02 TSG101 TFRC IRF3 DDX58 CLEC4G
8 positive regulation of interferon-alpha production GO:0032727 8.96 IRF3 DDX58

Sources for Argentine Hemorrhagic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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