MCID: ART140
MIFTS: 65

Arteries, Anomalies of

Categories: Cardiovascular diseases

Aliases & Classifications for Arteries, Anomalies of

MalaCards integrated aliases for Arteries, Anomalies of:

Name: Arteries, Anomalies of 57
Artery Disease 12 15
Arteriopathic Disease 73

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
arteries, anomalies of:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 108000
Disease Ontology 12 DOID:0050828
MedGen 42 C1876179
SNOMED-CT via HPO 69 263681008 49601007
UMLS 73 C0852949

Summaries for Arteries, Anomalies of

Disease Ontology : 12 A vascular disease that is located in an artery.

MalaCards based summary : Arteries, Anomalies of, also known as artery disease, is related to peripheral artery disease and renal artery disease. An important gene associated with Arteries, Anomalies of is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Vesicle-mediated transport and Lipoprotein metabolism. The drugs Everolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include an artery, heart and endothelial, and related phenotypes are abnormality of the cardiovascular system and Decreased free cholesterol

Description from OMIM: 108000

Related Diseases for Arteries, Anomalies of

Diseases related to Arteries, Anomalies of via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 487)
# Related Disease Score Top Affiliating Genes
1 peripheral artery disease 35.2 ACE APOB CRP IL6 NOS3
2 renal artery disease 34.9 ACE AGTR1 NOS3 REN
3 carotid artery disease 34.8 ACE APOA1 APOB APOE COG2 CRP
4 hyperlipoproteinemia, type iii 34.0 APOA1 APOB APOE COG2 LPA
5 peripheral vascular disease 34.0 ACE ALB APOA1 APOB CRP IL6
6 coronary heart disease 1 33.5 ACE APOA1 APOB APOE COG2 CRP
7 hypercholesterolemia, familial 33.5 APOA1 APOB APOE COG2 CRP INS
8 coronary artery anomaly 33.4 ACE AGTR1 APOA1 APOB APOE COG2
9 angina pectoris 33.3 ACE CRP EDN1 IL6 NOS3
10 fibromuscular dysplasia 33.3 ACE AGTR1 REN
11 aortic disease 33.3 APOE CRP IL6 REN
12 pulmonary embolism 33.2 ALB CRP PLAT TNNI3
13 tangier disease 33.1 APOA1 APOB APOE LPA
14 hyperlipidemia, familial combined 33.1 APOA1 APOB APOE COG2 LPA
15 atherosclerosis susceptibility 32.8 APOA1 APOB APOE CRP IL6 INS
16 hypercholesterolemia, autosomal dominant, type b 32.7 APOB APOE
17 cerebrovascular disease 32.5 ACE AGTR1 APOA1 APOB APOE CRP
18 arteriosclerosis 32.4 ACE APOA1 APOB APOE COG2 CRP
19 heart disease 32.3 ACE AGTR1 ALB APOA1 APOB APOE
20 ischemia 32.3 ACE EDN1 NOS3 PLAT TRPV1
21 intermittent claudication 32.2 ACE ALB CRP IL6
22 myocardial infarction 31.9 ACE AGTR1 ALB APOA1 APOB APOE
23 limb ischemia 31.8 ACE EDN1 IL6 NOS3 TNNI3
24 stroke, ischemic 31.8 ACE AGTR1 APOB APOE COG2 CRP
25 aortic valve disease 2 31.7 ACE CRP REN TNNI3
26 systolic heart failure 31.7 ACE CRP IL6
27 aortic atherosclerosis 31.6 ACE APOE LPA
28 aortic aneurysm, familial abdominal, 1 31.6 APOE CRP IL6
29 carotid stenosis 31.5 ACE APOE CRP
30 periodontitis 31.5 CRP IL6 TLR9
31 cardiogenic shock 31.5 CRP IL6 PLAT
32 congestive heart failure 31.5 ACE AGTR1 EDN1 REN
33 aortic coarctation 31.5 ACE AGTR1 EDN1 NOS3
34 apnea, obstructive sleep 31.4 CRP EDN1 IL6 INS REN
35 acute myocardial infarction 31.4 ACE AGTR1 APOA1 CRP EDN1 PLAT
36 microvascular complications of diabetes 5 31.3 ACE ALB INS NOS3
37 coronary stenosis 31.3 ACE ALB APOA1 APOB APOE CRP
38 myocardial stunning 31.3 AGTR1 EDN1 TNNI3
39 mitral valve disease 31.2 ACE AGTR1 NOS3
40 diabetic foot ulcers 31.2 APOE IL6
41 xanthomatosis 31.2 APOB APOE LPA
42 hemorrhage, intracerebral 31.1 ACE APOE PLAT
43 chronic kidney failure 31.1 ACE AGTR1 ALB CRP EDN1 IL6
44 end stage renal failure 31.1 ACE AGTR1 ALB CRP IL6
45 uremia 31.1 ALB CRP INS
46 diabetes mellitus 31.1 ACE AGTR1 ALB APOA1 APOB COG2
47 diastolic heart failure 31.1 ACE AGTR1 NOS3
48 microvascular complications of diabetes 3 31.1 ACE AGTR1 ALB INS REN
49 hyperuricemia 31.1 APOB CRP INS REN
50 sleep apnea 31.1 ACE APOE CRP EDN1 IL6 INS

Graphical network of the top 20 diseases related to Arteries, Anomalies of:



Diseases related to Arteries, Anomalies of

Symptoms & Phenotypes for Arteries, Anomalies of

Symptoms via clinical synopsis from OMIM:

57
Vascular:
abnormal radial, ulnar, or interosseous artery


Clinical features from OMIM:

108000

Human phenotypes related to Arteries, Anomalies of:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of the cardiovascular system 32 HP:0001626

GenomeRNAi Phenotypes related to Arteries, Anomalies of according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.92 APOA1 APOB APOE LPA

MGI Mouse Phenotypes related to Arteries, Anomalies of:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.41 APOA1 ACE APOB AGTR1 APOE IL6
2 homeostasis/metabolism MP:0005376 10.36 APOE ALB APOA1 ACE APOB AGTR1
3 growth/size/body region MP:0005378 10.29 AGTR1 APOE ACE APOB IL6 NOS3
4 cellular MP:0005384 10.26 ALB APOA1 APOB INS APOE IL6
5 immune system MP:0005387 10.22 APOE ACE APOB AGTR1 IL6 NOS3
6 hematopoietic system MP:0005397 10.2 AGTR1 APOE ACE IL6 COG2 INS
7 endocrine/exocrine gland MP:0005379 10.19 APOE ALB APOA1 ACE IL6 INS
8 mortality/aging MP:0010768 10.17 APOE ALB ACE APOB AGTR1 IL6
9 digestive/alimentary MP:0005381 10.16 APOE ALB IL6 NOS3 INS EDN1
10 adipose tissue MP:0005375 10.09 AGTR1 APOE ACE IL6 INS NOS3
11 liver/biliary system MP:0005370 10.07 APOE ALB APOA1 ACE APOB IL6
12 muscle MP:0005369 9.96 APOE ALB APOB IL6 NOS3 INS
13 nervous system MP:0003631 9.9 AGTR1 APOE APOB INS EDN1 IL6
14 renal/urinary system MP:0005367 9.73 APOE ALB ACE AGTR1 IL6 NOS3
15 reproductive system MP:0005389 9.28 ACE APOB INS APOE IL6 PLG

Drugs & Therapeutics for Arteries, Anomalies of

Drugs for Arteries, Anomalies of (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 961)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 159351-69-6 6442177
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
3
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53123-88-9 5284616 6436030 46835353
4
Clopidogrel Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 120202-66-6, 113665-84-2 60606
5
Ticagrelor Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 274693-27-5 9871419
6
Ticlopidine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 55142-85-3 5472
7
Cilostazol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 73963-72-1 2754
8
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6 772 46507594
9
Tirofiban Approved Phase 4,Phase 3,Phase 1 144494-65-5 60947
10
Chlorhexidine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 55-56-1 9552079 2713
11
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 79902-63-9 54454
12
Trimetazidine Approved, Investigational Phase 4 5011-34-7
13
Insulin Glargine Approved Phase 4,Phase 3,Not Applicable 160337-95-1
14
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 657-24-9 14219 4091
15
Zinc Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable,Early Phase 1 7440-66-6 23994
16
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-78-2 2244
17
Amlodipine Approved Phase 4,Phase 3,Not Applicable,Early Phase 1 88150-42-9 2162
18
Rivaroxaban Approved Phase 4,Phase 3,Phase 2 366789-02-8
19
Warfarin Approved Phase 4,Phase 3,Not Applicable 81-81-2 6691 54678486
20
Angiotensin II Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
21
Olmesartan Approved, Investigational Phase 4,Not Applicable 144689-24-7, 144689-63-4 158781 130881
22
Ranolazine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 142387-99-3, 95635-55-5 56959
23
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 33069-62-4 36314
24
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1994-09-7, 94-09-7 2337
25
Chromium Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 7440-47-3 27668
26
Rosiglitazone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 122320-73-4 77999
27
Pitavastatin Approved Phase 4,Phase 3,Not Applicable 147511-69-1, 147526-32-7 6366718 5282452
28
Ezetimibe Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 163222-33-1 150311
29
Lovastatin Approved, Investigational Phase 4,Phase 2,Phase 3 75330-75-5 53232
30
Acarbose Approved, Investigational Phase 4,Phase 3,Not Applicable 56180-94-0 441184
31
Bivalirudin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 128270-60-0 16129704
32
Metoprolol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 37350-58-6, 51384-51-1 4171
33
Thrombin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable
34
Vorapaxar Approved Phase 4,Phase 3,Phase 2 618385-01-6
35
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-61-7 60961
36
Dipyridamole Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-32-2 3108
37
Regadenoson Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 313348-27-5 219024
38
Enoxaparin Approved Phase 4,Phase 3,Not Applicable 9005-49-6 772
39
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3 73590-58-6 4594
40
Pantoprazole Approved Phase 4,Phase 3,Not Applicable 102625-70-7 4679
41
Dopamine Approved Phase 4,Phase 2,Phase 3,Not Applicable 51-61-6, 62-31-7 681
42
Fenoldopam Approved Phase 4 67227-56-9, 67227-57-0 3341
43
Coal tar Approved Phase 4,Phase 1,Phase 2 8007-45-2
44
Eptifibatide Approved, Investigational Phase 4,Phase 3,Phase 2 188627-80-7 123610
45
Menthol Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 2216-51-5 16666
46 sodium fluoride Approved Phase 4,Phase 2,Not Applicable 7681-49-4
47
Nicorandil Approved, Investigational Phase 4,Not Applicable 65141-46-0 47528
48
Phenprocoumon Approved, Investigational Phase 4 435-97-2 9908 54680692
49
Esmolol Approved Phase 4,Phase 3,Not Applicable 103598-03-4, 81147-92-4 59768
50
Nicardipine Approved, Investigational Phase 4,Early Phase 1 55985-32-5 4474

Interventional clinical trials:

(show top 50) (show all 6446)
# Name Status NCT ID Phase Drugs
1 The Beneficial Role of Percutaneous Coronary Intervention Over Optimal Medical Therapy in Elderly Patients With Coronary Artery Disease Unknown status NCT01508663 Phase 4 ARB, CCB, ACE-inhibitor, statin, Nitrate, Antiplate etc.
2 Safety and Efficacy of Low-dose Ticagrelor in Chinese Patients With Stable Coronary Artery Disease Unknown status NCT02514642 Phase 4 low-dose ticagrelor;Clopidogrel
3 A Trial to Evaluate Efficacy of Heart-protecting Musk Pill Unknown status NCT01897805 Phase 4 Heart-protecting Musk Pill;Placebo
4 Far Infrared Therapy on Peripheral Artery Disease in Hemodialysis Patients Unknown status NCT01095549 Phase 4
5 Effect of Cilostazol on Endothelial Progenitor Cells and Endothelial Function in Coronary Artery Disease Unknown status NCT02174939 Phase 4 Cilostazol;Dummy Placebo
6 Efficacy and Safety of Different Dose of Tirofiban in Interventional Treatment of Complex Coronary Artery Disease Unknown status NCT02294994 Phase 4 tirofiban
7 The Association Between Very Small Embryonic-like Stem Cells and the Prognosis of Coronary Artery Disease Patients Unknown status NCT01633359 Phase 4 Intensive statin;Routine statin
8 Firebird 2 Versus Excel Sirolimus-eluting Stent in Treating Real-world Patients With Coronary Artery Disease Unknown status NCT01373632 Phase 4
9 Pharmacodynamic Comparison of Rosuvastatin Versus Atorvastatin on Platelet Reactivity in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy With New P2Y12 Inhibitors (Trial gRANADa) Unknown status NCT02030054 Phase 4 Atorvastatin;Rosuvastatin
10 Low-dose Statins and Nutraceuticals in High-intensity Statin-intolerant Patients Unknown status NCT02001883 Phase 4 Association low-dose statin and nutraceuticals
11 Comparison of TIcagrelor and Clopidogrel in Patients With Coronary Artery diseaSe and Type 2 Diabetes Mellitus (TICS-DM) Unknown status NCT02457130 Phase 4 Ticagrelor;Clopidogrel
12 The ImPact of Trimetazidine on MicrOcirculation After Stenting for Stable Coronary Artery Disease Unknown status NCT02107144 Phase 4 trimetazidine
13 Can Insulin Glargine Improve Myocardial Function in Patients With T2D and Coronary Artery Disease (CAD) Unknown status NCT01035528 Phase 4 insulin glargine;metformin
14 Residual Platelet Activity In Advanced Peripheral Artery Disease Unknown status NCT01627431 Phase 4 Acetylsalicylic acid;Clopidogrel
15 Xience/Promus for Long Coronary Lesion Registry Unknown status NCT01147237 Phase 4
16 Cerebral Artery Stenosis, Coronary Artery Disease and Arrhythmia Unknown status NCT00247533 Phase 4
17 A Prospective Multicenter Trial Evaluating Helios Biodegradable Polymer SES Safety and Effectiveness in CAD Treatment Unknown status NCT01880879 Phase 4
18 Pharmacodynamic Effects of Atorvastatin vs. Rosuvastatin on Platelet Reactivity Unknown status NCT01567774 Phase 4 Atorvastatin;Rosuvastatin
19 Rivaroxaban in Patients With Atrial Fibrillation and Coronary Artery Disease Undergoing Percutaneous Coronary Intervention Unknown status NCT02334254 Phase 4 rivaroxaban and ticagrel therapy;triple antithrombotic regimen with warfarin, asipirin and clopidogrel
20 Effect of olmesaRtan on Walking distancE and quaLIty of lifE in Peripheral Artery Disease Patients With Hypertension Treated For Intermittent Claudication (RELIEF) Unknown status NCT02373462 Phase 4 Olmesartan;other anti-hypertensive drug
21 Pharmacodynamic Effects of Ranolazine Versus Amlodipine on Platelet Reactivity Unknown status NCT01490255 Phase 4 Ranolazine;Amlodipine
22 Effects of Nicotinic Acid Plus Simvastatin Versus Simvastatin Alone on Carotid and Femoral Intima-Media Thickness in Patients With Peripheral Artery Disease (NASCIT) Unknown status NCT00712049 Phase 4 simvastatin;Nicotinic Acid
23 Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease Study Unknown status NCT02642419 Phase 4 Rivaroxaban and single antiplatelet drug (aspirin, clopidogrel or prasugrel);Rivaroxaban
24 Efficacy Study of Stenting, Paclitaxel Eluting Balloon or Atherectomy to Treat Peripheral Artery Disease Unknown status NCT00986752 Phase 4
25 Metformin, Muscle Energetics, and Vascular Function in Older Adults With Peripheral Artery Disease Unknown status NCT01901224 Phase 4 Metformin 1000 mg;Placebo
26 Safety and Effectiveness of the Coronary Momo Stent Unknown status NCT01535625 Phase 4
27 Study Effects of Ginkgo Biloba Extract on Endothelial Cell Function and Genetic Effects on the Response to Ginkgo Biloba Extract in Diabetic Patients With Stable Coronary Artery Disease Unknown status NCT01038050 Phase 4 Ginkgo Biloba Extract (GBE)
28 Ranolazine, Ethnicity and the Metabolic Syndrome Unknown status NCT01304095 Phase 4 Ranolazine
29 Efficacy of Self-Expanding Nitinol S.M.A.R.T CONTROL Stent Versus Life Stent For The Atherosclerotic Femoro-Popliteal Arterial Disease Unknown status NCT01653600 Phase 4
30 Assessment of Surface Coverage of Two Types of DES in Diabetes Mellitus and Non- Diabetes Mellitus Unknown status NCT01023919 Phase 4
31 Overcoming High On-Treatment Platelet Reactivity (HPR) During Prasugrel Therapy With Ticagrelor Unknown status NCT01869309 Phase 4 Prasugrel;Ticagrelor
32 Endothelial Dysfunction in Subjects With History of Premature Coronary Artery Disease Unknown status NCT00917527 Phase 4 Atorvastatin
33 Rosiglitazone Therapy In The Prevention Of Coronary Artery Disease In Patients With Impaired Glucose Tolerance Unknown status NCT00733174 Phase 4 Rosiglitazone;Placebo
34 Multivessel Stenting Versus Staged Revascularization With Zotarolimus-eluting Stent for STEMI Unknown status NCT01781715 Phase 4
35 PharmacOdynamic compaRison of piTavastatin Versus atOrvastatin on Platelet Reactivity Unknown status NCT01648829 Phase 4 Atorvastatin;Pitavastatin
36 A Multicenter, Therapeutic Used Study to Evaluate the Efficacy and Safety of Pletaal SR Capsule (Cilostazol) in Subjects With Peripheral Arterial Disease Symptom Due to Chronic Occlusive Arterial Disease Unknown status NCT01711333 Phase 4 Pletaal SR capsule
37 Cholesterol-lowering Effects of nutraceuticaLs Versus Ezetimibe in Statin-intolerant Patients Unknown status NCT01807078 Phase 4 Ezetimibe
38 Impact of Acarbose on Abnormal Glucose Regulation in Patients With Coronary Artery Disease (AAA Trial) Unknown status NCT00858676 Phase 4 acarbose
39 Platelets Induced Vasodilation, in Vitro and in Vivo Study Unknown status NCT00152646 Phase 4 placebo, aspirine, clopidogrel
40 Periodontal Therapy in Coronary Artery Patients Unknown status NCT01609725 Phase 4
41 Plasma and Platelet microRNAs in Clopidogrel Low Response Patients Unknown status NCT02447809 Phase 4 Clopidogrel;acetylsalicylic acid (ASA)
42 Comparison of Biolimus-eluting Biodegradable Polymer, Everolimus-eluting and Sirolimus-eluting Coronary Stents Unknown status NCT01268371 Phase 4
43 Italian Diffuse/Multivessel Disease ABSORB Prospective Registry: IT-Disappears Unknown status NCT02004730 Phase 4
44 The Effects of Omega 3 and Vitamin E Supplementation on the Serum Antioxidant Enzymes and Gene Expressions of PGC-1a, h TERT, FOXOs and SIRTs in CAD Patients Unknown status NCT02011906 Phase 4
45 A Registry To Evaluate Safety And Effectiveness Of Everolimus Drug Eluting Stent For Coronary Revascularization Unknown status NCT01157455 Phase 4 Aspirin;Clopidogrel;Heparin or Bivalirudin
46 Diagnostic Performance of Noninvasive Fractional Flow Reserve From Computed Tomography Unknown status NCT01747317 Phase 4
47 Comparison of the Everolimus Eluting With the Biolimus A9 Eluting Stent Unknown status NCT01233453 Phase 4
48 Graft Patency After FFR-guided Versus Angio-guided CABG (GRAFFITI) Trial Unknown status NCT01810224 Phase 4
49 The Impact of Rosuvastatin on the Density Score of Coronary Artery Calcification in CAD Patients With Diabetes Mellitus Unknown status NCT02418884 Phase 4 rosuvastatin
50 Atorvastatin Plus Ezetimibe on Coronary Plaque Progression Unknown status NCT01086020 Phase 4 atorvastatin;atorvastatin plus ezetimibe

Search NIH Clinical Center for Arteries, Anomalies of

Genetic Tests for Arteries, Anomalies of

Anatomical Context for Arteries, Anomalies of

The Foundational Model of Anatomy Ontology organs/tissues related to Arteries, Anomalies of:

19
An Artery

MalaCards organs/tissues related to Arteries, Anomalies of:

41
Heart, Endothelial, Testes, Bone, Kidney, Bone Marrow, Brain

Publications for Arteries, Anomalies of

Articles related to Arteries, Anomalies of:

(show top 50) (show all 5243)
# Title Authors Year
1
Time trends in peripheral artery disease incidence, prevalence and secondary preventive therapy: a cohort study in The Health Improvement Network in the UK. ( 29358428 )
2018
2
Epicardial adipose tissue and carotid artery disease: Protocol for systematic review and meta-analysis. ( 29702973 )
2018
3
Peripheral Artery Disease and Continuous Flow Left Ventricle Assist Device: An Engaging Complement Analysis May Help to Guide Treatment. ( 29436002 )
2018
4
Novel Biomarkers for Coronary Restenosis Occurrence After Drug-Eluting Stent Implantation in Patients With Diabetes Having Stable Coronary Artery Disease. ( 29716394 )
2018
5
Microfibrillar-associated protein 4 variation in symptomatic peripheral artery disease. ( 29884190 )
2018
6
Validation of Multiparametric Ultrasonography Criteria with Digital Subtraction Angiography in Carotid Artery Disease: A Prospective Multicenter Study. ( 29797307 )
2018
7
Effect of cilostazol on platelet reactivity among patients with peripheral artery disease on clopidogrel therapy. ( 29408797 )
2018
8
Statin prescription rates and their facility-level variation in patients with peripheral artery disease and ischemic cerebrovascular disease: Insights from the Department of Veterans Affairs. ( 29600737 )
2018
9
The Role of Neurosonology in the Diagnosis and Management of Patients with Carotid Artery Disease: A Review. ( 29334161 )
2018
10
Beet the Best? Dietary Inorganic Nitrate to Augment Exercise Training in Lower Extremity Peripheral Artery Disease with Intermittent Claudication. ( 29976553 )
2018
11
Lipid-lowering treatment in peripheral artery disease. ( 29413998 )
2018
12
Revisiting angina pectoris with and without obstructive coronary artery disease. ( 29905817 )
2018
13
Ischemic stroke/transient ischemic attack events and carotid artery disease in the absence of or with minimal coronary artery calcification: Results from the Multi-Ethnic Study of Atherosclerosis. ( 29852401 )
2018
14
Under-utilization of statin medications in patients with peripheral artery disease or cerebrovascular disease. ( 29600738 )
2018
15
Incidence, timing, and type of first and recurrent ischemic events in patients with and without peripheral artery disease after an acute coronary syndrome. ( 29910052 )
2018
16
Associations of common variants at ALDH2 gene and the risk of stroke in patients with coronary artery diseases undergoing percutaneous coronary intervention. ( 29742731 )
2018
17
High serum leptin level is associated with peripheral artery disease in adult peritoneal dialysis patients. ( 29875588 )
2018
18
Review of biologic and behavioral risk factors linking depression and peripheral artery disease. ( 29801423 )
2018
19
Improvement of bilateral lower-limb muscle oxygenation by low-density lipoprotein apheresis in a patient with peripheral artery disease undergoing hemodialysis. ( 29422296 )
2018
20
Osteoprotegerin concentration is associated with the presence and severity of peripheral arterial disease in type 2 diabetes mellitus. ( 29313442 )
2018
21
Peripheral artery disease: How do genes and pharmacology interplay? ( 29894588 )
2018
22
Non-ST Elevation Myocardial Infarction and Severe Peripheral Artery Disease in a 20-Year-Old with Perinatally Acquired Human Immunodeficiency Virus Infection. ( 29808134 )
2018
23
Flip-Flop Phenomenon: Swallowing-Induced Arterial Displacement as an Indicator of Carotid Artery Disease. ( 29879697 )
2018
24
High-Sensitivity Cardiac Troponin I and the Diagnosis of Coronary Artery Disease in Patients With Suspected Angina Pectoris. ( 29444926 )
2018
25
Association between periodontitis and peripheral artery disease: a systematic review and meta-analysis. ( 29980169 )
2018
26
PCSK9 inhibition for LDL lowering and beyond - implications for patients with peripheral artery disease. ( 29412075 )
2018
27
Dual Anticoagulant and Antiplatelet Therapy for Coronary Artery Disease and Peripheral Artery Disease Patients. ( 29449336 )
2018
28
Translation and Validation of the Brazilian-Portuguese Short Version of Vascular Quality of Life Questionnaire in Peripheral Artery Disease Patients with Intermittent Claudication Symptoms. ( 29772330 )
2018
29
The effect of rheumatoid arthritis on the risk of cerebrovascular disease and coronary artery disease in young adults. ( 29861211 )
2018
30
Simultaneous Hybrid Operation Common Femoral Endarterectomy and Endovascular Treatment in Multilevel Peripheral Arterial Disease with Critical Limb Ischemia. ( 29915480 )
2018
31
Could the stress hyperglycemia ratio predict the clinical outcomes of coronary artery disease patients after percutaneous coronary intervention? ( 29407118 )
2018
32
Neovascularization in Vertebral Artery Atheroma-A Dynamic Contrast-Enhanced Magnetic Resonance Imaging-Based Comparative Study in Patients with Symptomatic and Asymptomatic Carotid Artery Disease. ( 29805083 )
2018
33
Critical Appraisal of the Quality of Evidence Addressing the Diagnosis, Prognosis, and Management of Peripheral Artery Disease in Patients With Diabetic Foot Ulceration. ( 29909087 )
2018
34
Multidetector CT angiography of the Circle of Willis: association of its variants with carotid artery disease and brain ischemia. ( 29922933 )
2018
35
Environment-wide association study to identify novel factors associated with peripheral arterial disease: Evidence from the National Health and Nutrition Examination Survey (1999-2004). ( 29366990 )
2018
36
Rivaroxaban plus aspirin, compared with aspirin alone, reduced cardiovascular events in patients with stable peripheral or carotid artery disease, but increased the risk of major bleeding. ( 29650723 )
2018
37
Improvement of the Quality of Evidence of Peripheral Artery Disease in Diabetic Foot Ulceration: Small Step for a Doctor, Giant Leap for Mankind? ( 29898825 )
2018
38
A Network-Biology Informed Computational Drug Repositioning Strategy to Target Disease Risk Trajectories and Comorbidities of Peripheral Artery Disease. ( 29888052 )
2018
39
The role of magnetic resonance angiography in peripheral artery disease. ( 29860155 )
2018
40
Saliva and serum biomarkers in periodontitis and coronary artery disease. ( 29972696 )
2018
41
Peripheral artery disease and transcatheter aortic valve implantation: The tip of the atherosclerotic iceberg. ( 29425563 )
2018
42
The associatA+on between serum serglycin level and coronary artery disease severity in patients with stable angina pectoris. ( 29313562 )
2018
43
Epidemiology of peripheral artery disease in Europe: VAS Educational Paper. ( 29936722 )
2018
44
Efficacy and safety of rivaroxaban compared with warfarin in patients with carotid artery disease and nonvalvular atrial fibrillation: Insights from the ROCKET AF trial. ( 29389037 )
2018
45
Risk of peripheral artery disease according to a healthy lifestyle score: The PREDIMED study. ( 29902701 )
2018
46
Protein biomarkers and coronary microvascular dilatation assessed by rubidium-82 PET in women with angina pectoris and no obstructive coronary artery disease. ( 29981522 )
2018
47
Association of circulating CTRP9 with soluble adhesion molecules and inflammatory markers in patients with type 2 diabetes mellitus and coronary artery disease. ( 29381773 )
2018
48
Risk Factors for Carotid Artery Disease and Chronic Kidney Disease: Same or Unique? ( 29405657 )
2018
49
Protecting Life and Limb in Peripheral Artery Disease. ( 29358343 )
2018
50
Editorial overview: Cardiovascular and renal: Novel therapies in peripheral artery disease. ( 29941177 )
2018

Variations for Arteries, Anomalies of

Expression for Arteries, Anomalies of

Search GEO for disease gene expression data for Arteries, Anomalies of.

Pathways for Arteries, Anomalies of

Pathways related to Arteries, Anomalies of according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.2 AGTR1 ALB APOA1 APOB APOE COG2
2
Show member pathways
12.46 ALB APOA1 APOB APOE LPA
3 11.92 ALB IL6 INS TNNI3
4 11.86 ALB APOA1 APOE TNNI3
5
Show member pathways
11.81 APOA1 APOB APOE LPA
6
Show member pathways
11.72 ALB APOA1 APOB APOE
7 11.67 EDN1 IL6 INS NOS3
8 11.62 AGTR1 EDN1 IL6 NOS3
9
Show member pathways
11.61 ALB APOA1 APOB APOE CRP IL6
10 11.53 ACE AGTR1 REN
11
Show member pathways
11.36 ACE AGTR1 NOS3 REN
12 11.33 ALB APOA1 INS
13 11.2 APOA1 IL6 TLR9
14 11.03 APOB IL6 LPA PLAT PLG
15 10.79 ACE PLAT PLG
16 10.67 PLAT PLG

GO Terms for Arteries, Anomalies of

Cellular components related to Arteries, Anomalies of according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 ACE ALB APOA1 APOB APOE CRP
2 blood microparticle GO:0072562 9.78 ALB APOA1 APOE PLG
3 endoplasmic reticulum lumen GO:0005788 9.73 ALB APOA1 APOB APOE IL6 INS
4 very-low-density lipoprotein particle GO:0034361 9.61 APOA1 APOB APOE
5 endocytic vesicle lumen GO:0071682 9.58 APOA1 APOB APOE
6 low-density lipoprotein particle GO:0034362 9.54 APOA1 APOB APOE
7 chylomicron GO:0042627 9.5 APOA1 APOB APOE
8 discoidal high-density lipoprotein particle GO:0034365 9.46 APOA1 APOE
9 extracellular space GO:0005615 9.44 ACE ALB APOA1 APOB APOE CRP
10 intermediate-density lipoprotein particle GO:0034363 9.33 APOA1 APOB APOE

Biological processes related to Arteries, Anomalies of according to GeneCards Suite gene sharing:

(show all 49)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.98 ALB APOA1 APOB APOE IL6
2 receptor-mediated endocytosis GO:0006898 9.95 ALB APOA1 APOB APOE
3 response to lipopolysaccharide GO:0032496 9.94 APOB EDN1 NOS3 REN
4 cholesterol metabolic process GO:0008203 9.87 APOA1 APOB APOE
5 cholesterol homeostasis GO:0042632 9.86 APOA1 APOB APOE
6 lipid transport GO:0006869 9.85 APOA1 APOB APOE LPA
7 retinoid metabolic process GO:0001523 9.82 APOA1 APOB APOE
8 regulation of blood pressure GO:0008217 9.73 ACE EDN1 NOS3 REN
9 amyloid-beta metabolic process GO:0050435 9.71 ACE REN
10 acute-phase response GO:0006953 9.71 CRP IL6 INS
11 regulation of blood vessel diameter GO:0097746 9.7 ACE AGTR1
12 fatty acid homeostasis GO:0055089 9.7 APOE INS
13 high-density lipoprotein particle assembly GO:0034380 9.7 APOA1 APOE
14 triglyceride catabolic process GO:0019433 9.7 APOA1 APOB APOE
15 heart contraction GO:0060047 9.69 ACE TNNI3
16 angiotensin maturation GO:0002003 9.69 ACE REN
17 cholesterol efflux GO:0033344 9.69 APOA1 APOB APOE
18 phospholipid efflux GO:0033700 9.68 APOA1 APOE
19 neutrophil mediated immunity GO:0002446 9.68 ACE IL6
20 negative regulation of blood vessel diameter GO:0097756 9.68 CRP INS
21 negative regulation of lipid storage GO:0010888 9.67 CRP IL6
22 very-low-density lipoprotein particle remodeling GO:0034372 9.67 APOA1 APOE
23 high-density lipoprotein particle clearance GO:0034384 9.67 APOA1 APOE
24 regulation of vasoconstriction GO:0019229 9.67 ACE AGTR1 EDN1
25 negative regulation of platelet activation GO:0010544 9.66 APOE NOS3
26 neuron projection regeneration GO:0031102 9.66 APOA1 APOE
27 chylomicron remnant clearance GO:0034382 9.65 APOB APOE
28 lipoprotein metabolic process GO:0042157 9.65 APOA1 APOB APOE
29 regulation of cholesterol transport GO:0032374 9.63 APOA1 APOE
30 negative regulation of hydrolase activity GO:0051346 9.63 APOA1 NOS3
31 high-density lipoprotein particle remodeling GO:0034375 9.63 ALB APOA1 APOE
32 regulation of Cdc42 protein signal transduction GO:0032489 9.62 APOA1 APOE
33 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.61 ACE AGTR1
34 negative regulation of cellular protein metabolic process GO:0032269 9.61 APOE EDN1
35 very-low-density lipoprotein particle clearance GO:0034447 9.6 APOB APOE
36 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.59 EDN1 NOS3
37 renin-angiotensin regulation of aldosterone production GO:0002018 9.58 AGTR1 REN
38 positive regulation of lipid biosynthetic process GO:0046889 9.58 APOA1 APOE INS
39 positive regulation of dendritic spine maintenance GO:1902952 9.57 APOE INS
40 lipoprotein catabolic process GO:0042159 9.56 APOB APOE
41 chylomicron assembly GO:0034378 9.54 APOA1 APOB APOE
42 positive regulation of cholesterol esterification GO:0010873 9.5 AGTR1 APOA1 APOE
43 chylomicron remodeling GO:0034371 9.43 APOA1 APOB APOE
44 lipoprotein biosynthetic process GO:0042158 9.33 APOA1 APOB APOE
45 low-density lipoprotein particle remodeling GO:0034374 9.26 AGTR1 APOB APOE LPA
46 cellular protein metabolic process GO:0044267 9.17 ALB APOA1 APOB APOE IL6 INS
47 proteolysis GO:0006508 10.12 ACE ENSG00000264813 LPA PLAT PLG REN
48 lipid metabolic process GO:0006629 10.1 APOA1 APOB APOE LPA TRPV1
49 positive regulation of gene expression GO:0010628 10.02 APOB CRP IL6 INS TLR9

Molecular functions related to Arteries, Anomalies of according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.8 ACE ENSG00000264813 LPA PLAT PLG REN
2 endopeptidase activity GO:0004175 9.65 ACE PLG REN
3 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.46 APOA1 APOE
4 lipoprotein particle binding GO:0071813 9.43 APOA1 APOE
5 peptidyl-dipeptidase activity GO:0008241 9.37 ACE ENSG00000264813
6 lipid transporter activity GO:0005319 9.33 APOA1 APOB APOE
7 bradykinin receptor binding GO:0031711 9.26 ACE AGTR1
8 low-density lipoprotein particle receptor binding GO:0050750 9.13 APOB APOE CRP
9 cholesterol transporter activity GO:0017127 8.8 APOA1 APOB APOE
10 protein binding GO:0005515 10.36 AGTR1 ALB APOA1 APOB APOE COG2

Sources for Arteries, Anomalies of

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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