MCID: ART140
MIFTS: 60

Arteries, Anomalies of

Categories: Cardiovascular diseases

Aliases & Classifications for Arteries, Anomalies of

MalaCards integrated aliases for Arteries, Anomalies of:

Name: Arteries, Anomalies of 57
Artery Disease 12 15
Arteriopathic Disease 72

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
arteries, anomalies of:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:0050828
OMIM 57 108000
MedGen 42 C1876179
UMLS 72 C0852949

Summaries for Arteries, Anomalies of

Disease Ontology : 12 A vascular disease that is located in an artery.

MalaCards based summary : Arteries, Anomalies of, also known as artery disease, is related to peripheral artery disease and hyperlipoproteinemia, type iii. An important gene associated with Arteries, Anomalies of is REN (Renin), and among its related pathways/superpathways are Vesicle-mediated transport and p70S6K Signaling. The drugs Nitric Oxide and Coal tar have been mentioned in the context of this disorder. Affiliated tissues include an artery, heart and endothelial, and related phenotypes are abnormality of the cardiovascular system and Decreased free cholesterol

More information from OMIM: 108000

Related Diseases for Arteries, Anomalies of

Diseases related to Arteries, Anomalies of via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1083)
# Related Disease Score Top Affiliating Genes
1 peripheral artery disease 35.2 VCAM1 NOS3 IL6 CRP APOB ACE
2 hyperlipoproteinemia, type iii 35.1 LPA COG2 APOE APOB APOA1
3 pulmonary artery disease 35.0 TNNI3 PLG PLAT ALB
4 carotid artery disease 35.0 REN PLG LPA CRP COG2 APOE
5 renal artery disease 34.8 REN NOS3 AGTR1 AGT ACE
6 peripheral vascular disease 34.3 VCAM1 PLAT LPA IL6 CRP APOB
7 coronary artery anomaly 33.9 TNNI3 PLG PLAT NOS3 LPA EDN1
8 angina pectoris 33.7 PLAT NOS3 IL6 EDN1 CRP ACE
9 coronary heart disease 1 33.6 PLAT NOS3 MIR126 LPA INS IL6
10 atherosclerosis susceptibility 33.5 VCAM1 NOS3 LPA INS IL6 CRP
11 aortic disease 33.3 REN IL6 CRP APOE
12 fibromuscular dysplasia 33.3 REN AGTR1 AGT ACE
13 tangier disease 33.3 LPA APOE APOB APOA1
14 pulmonary embolism 33.3 TNNI3 PLAT CRP ALB
15 hyperalphalipoproteinemia 1 33.3 APOE APOB APOA1
16 stroke, ischemic 33.1 REN PLG PLAT NOS3 LPA CRP
17 arteriosclerosis 32.9 VCAM1 LPA INS IL6 EDN1 CRP
18 ischemia 32.9 PLAT NOS3 EDN1 ACE
19 intermittent claudication 32.8 IL6 CRP ALB ACE
20 vascular disease 32.7 VCAM1 REN PLG PLAT NOS3 LPA
21 intermediate coronary syndrome 32.6 TNNI3 PLG PLAT IL6 CRP ACE
22 carotid stenosis 32.6 CRP APOE ACE
23 coronary stenosis 32.6 TNNI3 IL6 CRP APOE APOB APOA1
24 limb ischemia 32.5 TNNI3 NOS3 IL6 EDN1 ACE
25 congestive heart failure 32.5 REN EDN1 AGTR1 ACE
26 heart disease 32.5 TNNI3 REN PLAT NOS3 INS IL6
27 lipid metabolism disorder 32.4 LPA INS CRP COG2 APOE APOB
28 hypertriglyceridemia, familial 32.2 INS APOE APOB APOA1
29 myocardial infarction 32.2 TNNI3 REN PLG PLAT NOS3 LPA
30 homocysteinemia 32.2 NOS3 CRP ALB
31 heart valve disease 32.1 REN CRP ACE
32 atrial fibrillation 32.0 PLAT CRP AGTR1 AGT ACE
33 hyperuricemia 31.9 REN INS CRP APOB
34 end stage renal failure 31.9 IL6 CRP APOB ALB AGTR1 AGT
35 aortic valve disease 2 31.9 REN CRP AGT ACE
36 acute myocardial infarction 31.9 TNNI3 PLG PLAT EDN1 CRP APOB
37 generalized atherosclerosis 31.8 CRP APOE ACE
38 cerebrovascular disease 31.8 VCAM1 REN PLAT INS IL6 CRP
39 aortic atherosclerosis 31.8 LPA APOE ACE
40 proteasome-associated autoinflammatory syndrome 1 31.8 VCAM1 INS IL6 CRP ALB
41 sleep apnea 31.7 REN NOS3 INS IL6 EDN1 CRP
42 pulmonary edema 31.7 REN NOS3 EDN1 CRP ACE
43 microvascular complications of diabetes 3 31.7 INS ALB AGTR1 AGT ACE
44 renovascular hypertension 31.6 REN NOS3 EDN1 AGTR1 ACE
45 kidney disease 31.6 REN NOS3 LPA INS IL6 EDN1
46 myocardial stunning 31.6 TNNI3 EDN1 AGTR1
47 systolic heart failure 31.6 IL6 EDN1 CRP ACE
48 mitral valve disease 31.6 NOS3 AGTR1 AGT ACE
49 pulmonary hypertension 31.6 REN PLAT NOS3 EDN1 ACE
50 kawasaki disease 31.5 IL6 CRP ALB

Graphical network of the top 20 diseases related to Arteries, Anomalies of:



Diseases related to Arteries, Anomalies of

Symptoms & Phenotypes for Arteries, Anomalies of

Human phenotypes related to Arteries, Anomalies of:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of the cardiovascular system 32 HP:0001626

Symptoms via clinical synopsis from OMIM:

57
Vascular:
abnormal radial, ulnar, or interosseous artery

Clinical features from OMIM:

108000

GenomeRNAi Phenotypes related to Arteries, Anomalies of according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.92 APOA1 APOB APOE LPA

MGI Mouse Phenotypes related to Arteries, Anomalies of:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.43 ACE AGT AGTR1 APOA1 APOB APOE
2 homeostasis/metabolism MP:0005376 10.36 ACE AGT AGTR1 ALB APOA1 APOB
3 growth/size/body region MP:0005378 10.32 ACE AGT AGTR1 APOB APOE COG2
4 immune system MP:0005387 10.22 ACE AGT AGTR1 APOB APOE CRP
5 hematopoietic system MP:0005397 10.2 ACE AGTR1 APOE COG2 IL6 INS
6 mortality/aging MP:0010768 10.2 ACE AGT AGTR1 ALB APOB APOE
7 endocrine/exocrine gland MP:0005379 10.19 ACE ALB APOA1 APOE EDN1 IL6
8 digestive/alimentary MP:0005381 10.11 ALB APOE EDN1 IL6 INS NOS3
9 adipose tissue MP:0005375 10.08 ACE AGT AGTR1 APOE IL6 INS
10 liver/biliary system MP:0005370 10.07 ACE AGT ALB APOA1 APOB APOE
11 muscle MP:0005369 10 AGT ALB APOB APOE EDN1 IL6
12 nervous system MP:0003631 9.9 AGT AGTR1 APOB APOE EDN1 IL6
13 renal/urinary system MP:0005367 9.7 ACE AGT AGTR1 ALB APOE EDN1
14 reproductive system MP:0005389 9.36 ACE AGT APOB APOE IL6 INS

Drugs & Therapeutics for Arteries, Anomalies of

Drugs for Arteries, Anomalies of (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 920)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitric Oxide Approved Phase 4 10102-43-9 145068
2
Coal tar Approved Phase 4 8007-45-2
3
Nicardipine Approved, Investigational Phase 4 55985-32-5 4474
4
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
5
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
6
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
7
Fenoldopam Approved Phase 4 67227-56-9, 67227-57-0 3341
8
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
9
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
10
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
11
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
12
Udenafil Approved, Investigational Phase 4 268203-93-6 6918523
13
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
14
Salicylic acid Approved, Investigational, Vet_approved Phase 4 69-72-7 338
15
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
16
Eplerenone Approved Phase 4 107724-20-9 150310 443872
17
Ticlopidine Approved Phase 4 55142-85-3 5472
18
Simvastatin Approved Phase 4 79902-63-9 54454
19
Pravastatin Approved Phase 4 81093-37-0 54687
20
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
21
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
22
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
23
Probucol Approved, Investigational Phase 4 23288-49-5 4912
24
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
25
Zinc Approved, Investigational Phase 4 7440-66-6 32051
26
Edoxaban Approved Phase 4 480449-70-5
27
Remifentanil Approved Phase 4 132875-61-7 60815
28
Ramipril Approved Phase 4 87333-19-5 5362129
29
Glipizide Approved, Investigational Phase 4 29094-61-9 3478
30
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
31
Lovastatin Approved, Investigational Phase 4 75330-75-5 53232
32
Saxagliptin Approved Phase 4 361442-04-8 11243969
33
Varenicline Approved, Investigational Phase 4 249296-44-4 5310966
34
Digoxin Approved Phase 4 20830-75-5 30322 2724385
35
Repaglinide Approved, Investigational Phase 4 135062-02-1 65981
36
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
37
Histamine Approved, Investigational Phase 4 51-45-6 774
38
Ranitidine Approved Phase 4 66357-35-5, 66357-59-3 3001055
39
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
40
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
41
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
42
Cosyntropin Approved Phase 4 16960-16-0 16129617
43
Etomidate Approved Phase 4 33125-97-2 36339 667484
44
Citalopram Approved Phase 4 59729-33-8 2771
45
Magnesium citrate Approved Phase 4 3344-18-1
46
Magnesium oxide Approved Phase 4 1309-48-4 14792
47
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
48
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
49
Methylnaltrexone Approved Phase 4 916055-93-1, 83387-25-1 6603824
50
Nifedipine Approved Phase 4 21829-25-4 4485

Interventional clinical trials:

(show top 50) (show all 6088)
# Name Status NCT ID Phase Drugs
1 Comparison of Biolimus-eluting Biodegradable Polymer, Everolimus-eluting and Sirolimus-eluting Coronary Stents Unknown status NCT01268371 Phase 4
2 A Multi Center Registry to Evaluate Multiple Stenting Using by Everolimus-eluting Stents for Treatment of Long Coronary Artery Disease Unknown status NCT01147237 Phase 4
3 Randomized Controlled Clinical Study to Compare the Efficacy and Safety of Different Dose of Tirofiban in Interventional Treatment of Complex Coronary Artery Disease Unknown status NCT02294994 Phase 4 tirofiban
4 Clinical Evaluation of the Momo Cobalt-Chromium Coronary Stent System for the Treatment of Patients With Coronary Artery Disease Unknown status NCT01535625 Phase 4
5 Comparison of Efficacy and Safety of Ivabradine Versus Metoprolol for Controlling Heart Rate Prior to 640-Slice Computed Tomographic Angiography in Elective Patients Unknown status NCT01755663 Phase 4 Ivabradine and Metoprolol
6 Ranolazine, Ethnicity and the Metabolic Syndrome - REMS Study Unknown status NCT01304095 Phase 4 Ranolazine
7 The Effects of Omega 3 and Vitamin E Supplementation on the Serum Antioxidant Enzymes and Gene Expressions of PGC-1a, h TERT, FOXOs and SIRTs in CAD Patients Unknown status NCT02011906 Phase 4
8 Graft Patency After FFR-guided Versus Angio-guided CABG: a Prospective, Multicenter, Multinational, Randomized (1:1) Controlled Trial Unknown status NCT01810224 Phase 4
9 Impact of Paclitaxel-eluting Stent for Small Coronary Artery Disease Unknown status NCT00955214 Phase 4
10 Prospective Multicenter Registry of Hybrid Coronary Artery Revascularization Combined With Surgical Bypass and Percutaneous Coronary Intervention Using Everolimus Eluting Metallic Stents Unknown status NCT02894255 Phase 4
11 Overcoming High On-Treatment Platelet Reactivity (HPR) During Prasugrel Therapy Unknown status NCT01869309 Phase 4 Prasugrel;Ticagrelor
12 Simultaneous Acquisition of Intravascular Ultrasound and Near Infrared Spectroscopy Data in the Coronary Artery Study Unknown status NCT02154295 Phase 4
13 Rosiglitazone Therapy In The Prevention Of Coronary Artery Disease In Patients With Impaired Glucose Tolerance Unknown status NCT00733174 Phase 4 Rosiglitazone;Placebo
14 A Randomized, Double-blind, Multi-centered, Placebo-controlled Trial to Examine Effects of Heart-protecting Musk Pill on Clinical Outcome in Patients With Chronic Stable Coronary Artery Disease Unknown status NCT01897805 Phase 4 Heart-protecting Musk Pill;Placebo
15 Study of Curative Effect Evaluation of Shexiang Baoxin Pill on Coronary Artery Disease Not Amenable to Revascularization on the Basis of Western Medicine Therapy Unknown status NCT03072121 Phase 4 Shexiang Baoxin pill;SBP placebo;Aspirin Enteric-coated Tablets;Clopidogrel Hydrogen Sulfate 75 MG Oral Tablet;Atorvastatin Calcium;Isosorbide Mononitrate Tab 20 MG;Metoprolol Tartrate Tab 25 MG;Trimetazidine Dihydrochloride Tablets
16 Study of Curative Effect Evaluation of DanLou Tablet on Coronary Artery Disease Not Amenable to Revascularization on the Basis of Western Medicine Therapy Unknown status NCT03072082 Phase 4 Danlou Tablet;DanLou Tablet placebo;Aspirin Enteric-coated Tablets;Clopidogrel Hydrogen Sulfate 75 MG Oral Tablet;Atorvastatin calcium;Isosorbide Mononitrate Tab 20 MG;Metoprolol Tartrate Tab 25 MG;Trimetazidine Dihydrochloride Tablets
17 Randomized Trial of the Association Between Low-Dose Statins and Nutraceuticals in High-intEnsity Statin-intoleRant patiENts With Very High Risk Coronary Artery diseasE Unknown status NCT02001883 Phase 4 Association low-dose statin and nutraceuticals
18 The Beneficial Role of Percutaneous Coronary Intervention Over Optimal Medical Therapy in Elderly Patients (Age > 75 Years Old) With Coronary Artery Disease: a Randomized Controlled Study Unknown status NCT01508663 Phase 4 ARB, CCB, ACE-inhibitor, statin, Nitrate, Antiplate etc.
19 A Prospective Multicenter Trial Evaluating Helios Biodegradable Polymer Sirolimus-eluting Stent Safety and Effectiveness in Treatment of Coronary Artery Disease Unknown status NCT01880879 Phase 4
20 Phase 4 Study of Patients Receiving BNP or NTG (IV) During Angioplasty, Re-examined 24 Hours Later Using the Flow-mediated Brachial Artery Dilation Study, and Blood Assays for Pro BNP and ET1 Unknown status NCT00262574 Phase 4 Nesiritide,
21 Apposition Assessed Using Optical Coherence Tomography of Chromium Stents Eluting Everolimus From Cobalt Versus Platinum Alloy Platforms. Unknown status NCT01776567 Phase 4
22 A Comparative Evaluation of Efficacy and Safety in the 3-Months DAPT Group vs. the 6-Months DAPT Group of Patients Treated With the Coroflex ISAR Stent; A Prospective, Multicenter, Randomized, Open-Label Clinical Trial Unknown status NCT02609698 Phase 4 3 months DAPT;6 months DAPT
23 Impact of Periodontal Therapy in Flow-mediated Dilation and Serum Levels of Cardiovascular Risk Biomarkers in Coronary Artery Disease Patients: 12 Months Randomized Controlled Trial Unknown status NCT01609725 Phase 4
24 Comparison of the Pharmacodynamic Effects of RanOlazine Versus aMlodipine on Platelet Reactivity in Stable Patients With Coronary Artery Disease Treated With Dual ANtiplatelet Therapy - The ROMAN Randomized Study Unknown status NCT01490255 Phase 4 Ranolazine;Amlodipine
25 The 001-DIOR Multicenter Registry (A Novel Percutaneous Coronary Intervention With the New Paclitaxel-eluting Balloon DIOR in Ostial Bifurcated Lesions) Unknown status NCT01375465 Phase 4
26 Efficacy and Safety of the YUKON Drug Eluting Stent in Diffuse Coronary Artery Disease Unknown status NCT01418794 Phase 4
27 Effect of Preoperative Aspirin in Patients Undergoing Off-pump Coronary Artery Bypass Grafting: A Double-blind, Placebo-controlled, Randomized Trial Unknown status NCT03049085 Phase 4 Aspirin;vitamin C
28 Randomized Placebo-controlled Crossover Trial of Endothelial Function Improvement in Subjects With History of Premature Coronary Artery Disease Unknown status NCT00917527 Phase 4 Atorvastatin
29 Multicenter, Randomized, Non-inferiority Study of Firebird 2 Versus Excel Sirolimus-eluting Stent in Treating Real-world Patients With Coronary Artery Disease Unknown status NCT01373632 Phase 4
30 Individual-Patient-Data Pooled-Analysis of Diagnostic Accuracy of Noninvasive Fractional Flow Reserve From Anatomic CT Angiography Unknown status NCT01747317 Phase 4
31 Multivessel Stenting and Staged Revascularization for ST-elevation Myocardial Infarction Patients With Resolute Integrity Stents Unknown status NCT01781715 Phase 4
32 Cilostazol Enhances the Number and Functions of Circulating Endothelial Progenitor Cells and Endothelial Function Mediated Through Modification of Vasculogenesis and Angiogenesis Factors in Patients With Stable Coronary Artery Disease Unknown status NCT02174939 Phase 4 Cilostazol;Dummy Placebo
33 Pharmacodynamic Effects of Atorvastatin vs. Rosuvastatin on pLatelet Reactivity in Stable Patients With Coronary Artery Disease Treated With Dual Antiplatelet Therapy Unknown status NCT01567774 Phase 4 Atorvastatin;Rosuvastatin
34 Use of Hypertonic Versus Isotonic Solutions in Off Pump Coronary Artery Bypass Graft Surgery Targeting the Left Marginal Branch Unknown status NCT01463917 Phase 4 Hypertonic solution;Isotonic
35 Comparison of Vascular Remodeling Between Different Antianginal Medication Evaluated by Noninvasive ECG-gated Fundus Photographic Evaluation Unknown status NCT01162902 Phase 4 Diltiazem treated group;Bisoprolol treated group;Candesartan treated group
36 Prospective Randomized Study of the Paclitaxel-Coated Balloon Catheter in Bifurcated Coronary Lesions / BABILON Study (Paclitaxel-Coated Balloon in Bifurcated Lesions) Unknown status NCT01278186 Phase 4
37 A Pilot Study Exploring Efficacy and Safety of Amlodipine in the Stented Angina Patients Unknown status NCT01120327 Phase 4 Placebo;Amlodipine
38 Comparison of Hyperemic Efficacy Between Nicorandil and Adenosine for Fractional Flow Reserve (FFR) Measurement Unknown status NCT01331902 Phase 4
39 2-phased Randomized Comparison Between PromusTMElementTM Versus Xience PRIME® Stent Unknown status NCT01581515 Phase 4
40 Telmisartan vs Ramipril for Reduction of Inflammation and Recruitment of Endothelial Progenitor Cells After Acute Coronary Syndrome Unknown status NCT00702936 Phase 4 TELMISARTAN;RAMIPRIL
41 Randomized Comparison of the CHOlesterol-lowering Effects of nutraceuticaLs Versus Ezetimibe in Statin-intolerant patientS - The CHOLESS Trial Unknown status NCT01807078 Phase 4 Ezetimibe
42 Rivaroxaban in Patients With Atrial Fibrillation and Coronary Artery Disease Undergoing Percutaneous Coronary Intervention Unknown status NCT02334254 Phase 4 rivaroxaban and ticagrel therapy;triple antithrombotic regimen with warfarin, asipirin and clopidogrel
43 Assessment of Surface Coverage of Polymer-based Sirolimus-eluting Stent( Cypher ) or Polymer-free Paclitaxel-eluting Stent (YinYi )in Diabetes Mellitus and Non- Diabetes Mellitus Patients by Optical Coherence Tomography Unknown status NCT01023919 Phase 4
44 Prospective Randomized Trial On Radiation Dose Estimates Of CT Angiography In Patients Applying Iterative Image Reconstruction Techniques - The PROTECTION V Study - Unknown status NCT01453712 Phase 4
45 The Impact of Rosuvastatin on the Density Score of Coronary Artery Calcification in CAD Patients With Diabetes Mellitus Unknown status NCT02418884 Phase 4 rosuvastatin
46 Intracoronary Brachytherapy for Recurrent Restenosis After Multiple Drug-Eluting Stents. Short Title: Scripps V Unknown status NCT00714545 Phase 4
47 The Efficacy and Safety of Paclitaxel-eluting SeQuent Please Drug-Eluting Balloon for Treatment of lesiOns in Native smalL coronarY Arteries (DEB-ONLY) Unknown status NCT01903902 Phase 4
48 Relationship Between Initial Plaque Characteristics and Stent Surface Coverage Patterns After Sirolimus-eluting Stent Implantation Assessment by Optical Coherence Tomography Unknown status NCT01024179 Phase 4
49 Same Lipid Lowering by Atorvastatin Versus Atorvastatin Plus Ezetimibe on Coronary Plaque Progression Unknown status NCT01086020 Phase 4 atorvastatin;atorvastatin plus ezetimibe
50 Assessment of the Effects of Ezetimibe on Coronary Plaque Volume in Patients With Acute Coronary Syndrome Unknown status NCT01068093 Phase 4 Ezetimibe

Search NIH Clinical Center for Arteries, Anomalies of

Genetic Tests for Arteries, Anomalies of

Anatomical Context for Arteries, Anomalies of

The Foundational Model of Anatomy Ontology organs/tissues related to Arteries, Anomalies of:

19
An Artery

MalaCards organs/tissues related to Arteries, Anomalies of:

41
Heart, Endothelial, Testes, Kidney, Bone, Liver, Lung

Publications for Arteries, Anomalies of

Articles related to Arteries, Anomalies of:

(show top 50) (show all 30005)
# Title Authors PMID Year
1
Effects of ADIPOQ polymorphisms on individual susceptibility to coronary artery disease: a meta-analysis. 38
30879388 2019
2
Design of CTP-PRO study (impact of stress Cardiac computed Tomography myocardial Perfusion on downstream resources and PROgnosis in patients with suspected or known coronary artery disease: A multicenter international study). 38
31230938 2019
3
Association of COX2 -765G>C promoter polymorphism and coronary artery disease in Korean population. 38
31165994 2019
4
Selective neuronal damage and blood pressure in atherosclerotic major cerebral artery disease. 38
31127015 2019
5
Cadmium level and severity of peripheral artery disease in patients with coronary artery disease. 38
30152247 2019
6
[Lower extremity artery disease. Angioplasty and stenting in 2019.] 38
31070318 2019
7
[Invasive physiological evaluation of coronary artery disease]. 38
31070312 2019
8
Polygenic predisposition to breast cancer and the risk of coronary artery disease. 38
31155334 2019
9
Design and rationale of the COMPLETE trial: A randomized, comparative effectiveness study of complete versus culprit-only percutaneous coronary intervention to treat multivessel coronary artery disease in patients presenting with ST-segment elevation myocardial infarction. 38
31326681 2019
10
Long-term follow-up and safety assessment of angiogenic gene therapy trial VIF-CAD: Transcatheter intramyocardial administration of a bicistronic plasmid expressing VEGF-A165/bFGF cDNA for the treatment of refractory coronary artery disease. 38
31288177 2019
11
The impact of GDF-15, a biomarker for metformin, on the risk of coronary artery disease, breast and colorectal cancer, and type 2 diabetes and metabolic traits: a Mendelian randomisation study. 38
31161347 2019
12
Danish study of Non-Invasive testing in Coronary Artery Disease 2 (Dan-NICAD 2): Study design for a controlled study of diagnostic accuracy. 38
31323454 2019
13
Long-term clinical outcomes according to the mean observed blood pressure in patients with coronary artery disease after drug-eluting stent implantation. 38
31045965 2019
14
Meta-analysis of fractional flow reserve guided complete revascularization versus infarct related artery only revascularization in patients with ST-elevation myocardial infarction and multivessel coronary artery disease. 38
31094897 2019
15
Unusual SPECT myocardial perfusion imaging results in the setting of ventricular hypertrophy and non-obstructive coronary artery disease should suggest Anderson-Fabry disease. 38
30938411 2019
16
Optimal Blood Pressure Thresholds for Minimal Coronary Artery Disease Risk in Type 1 Diabetes. 38
31248910 2019
17
Circulating microRNAs in suspected stable coronary artery disease: A coronary computed tomography angiography study. 38
31141242 2019
18
Severity of obstructive sleep apnea and extension of coronary artery disease. 38
30552556 2019
19
Proteinuria and Risk of Lower-Extremity Amputation in Patients With Peripheral Artery Disease. 38
31308019 2019
20
Roles of Growth Differentiation Factor 15 in Atherosclerosis and Coronary Artery Disease. 38
31432727 2019
21
Raising the bar for appropriateness in the care of patients with peripheral artery disease. 38
31334415 2019
22
Quantitative myocardial perfusion in coronary artery disease: A perfusion mapping study. 38
30684288 2019
23
Comparing the Modified History, Electrocardiogram, Age, Risk Factors, and Troponin Score and Coronary Artery Disease Consortium Model for Predicting Obstructive Coronary Artery Disease and Cardiovascular Events in Patients With Acute Chest Pain. 38
31348071 2019
24
Polygenetic risk for coronary artery disease increases hospitalization burden and mortality. 38
31360760 2019
25
Inverse association of alanine aminotransferase within normal range with prognosis in patients with coronary artery disease. 38
31254501 2019
26
Association of 584C/T polymorphism in endothelial lipase gene with risk of coronary artery disease. 38
31020688 2019
27
Cardiac troponins predict adverse clinical outcomes in stable coronary artery disease: a dose-response meta-analysis of prospective studies. 38
30974974 2019
28
Cutaneous microvascular function in patients with obstructive or non-obstructive coronary artery disease evaluated by laser speckle contrast imaging. 38
31082448 2019
29
Lipoprotein (a) level is associated with plaque vulnerability in patients with coronary artery disease: An optical coherence tomography study. 38
31245530 2019
30
Effect of Age and Sex on Outcomes After Stenting or Bypass Surgery in Left Main Coronary Artery Disease. 38
31301759 2019
31
Advanced glycation end product carboxymethyl-lysine and risk of incident peripheral artery disease in older adults: The Cardiovascular Health Study. 38
31064218 2019
32
Dietary approach to stop hypertension diet and risk of coronary artery disease: a meta-analysis of prospective cohort studies. 38
30810409 2019
33
Elevated levels of circulating microvesicles in coronary artery disease patients with type 2 diabetes and albuminuria: Effects of exercise training. 38
31023084 2019
34
The Emerging Role of Bone Markers in Diagnosis and Risk Stratification of Patients With Coronary Artery Disease. 38
30696256 2019
35
Admission Heart Rate Is Associated With Coronary Artery Disease Severity and Complexity in Patients With Acute Coronary Syndrome. 38
30813736 2019
36
Vascular Inflammation, Calf Muscle Oxygen Saturation, and Blood Glucose are Associated With Exercise Pressor Response in Symptomatic Peripheral Artery Disease. 38
30913894 2019
37
Clinicopathologic Features and Calcium Deposition Patterns in Calciphylaxis: Comparison With Gangrene, Peripheral Artery Disease, Chronic Stasis, and Thrombotic Vasculopathy. 38
31192861 2019
38
Risk of new-onset atrial fibrillation after drug-eluting stent implantation in patients with stable coronary artery disease. 38
31153652 2019
39
Drug-Eluting Stent Versus Coronary Artery Bypass Grafting for Diabetic Patients With Multivessel and/or Left Main Coronary Artery Disease: A Meta-Analysis. 38
30995117 2019
40
Risk factors for coronary artery disease in young patients with stable angina pectoris 38
31385674 2019
41
Myocardial Dysfunction and Coronary Artery Disease as Therapeutic Targets in Heart Failure. 38
31403847 2019
42
Magnetic resonance imaging based modeling of microvascular perfusion in patients with peripheral artery disease. 38
31331663 2019
43
Observational study of the medical management of patients with peripheral artery disease. 38
31259387 2019
44
An Analysis of Cost-Effectiveness of Stents Used in the Treatment of Coronary Artery Disease 38
31290640 2019
45
Assessing Patient Preferences for Shared Decision-Making in Peripheral Artery Disease. 38
31412733 2019
46
Surgical Ineligibility and Long-Term Outcomes in Patients With Severe Coronary Artery Disease. 38
31434812 2019
47
Genetics of early-onset coronary artery disease: from discovery to clinical translation. 38
31436558 2019
48
Correlating Pathology to Imaging: Improved Insights Into Peripheral Artery Disease? 38
30553659 2019
49
Left atrial function, peripheral artery disease, ARVD, and more. 38
31375655 2019
50
Outcomes with cilostazol after endovascular therapy of peripheral artery disease. 38
31023156 2019

Variations for Arteries, Anomalies of

Expression for Arteries, Anomalies of

Search GEO for disease gene expression data for Arteries, Anomalies of.

Pathways for Arteries, Anomalies of

Pathways related to Arteries, Anomalies of according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.22 INS COG2 APOE APOB APOA1 ALB
2
Show member pathways
12.86 VCAM1 REN INS IL6 AGTR1 AGT
3
Show member pathways
12.48 LPA APOE APOB APOA1 ALB
4
Show member pathways
12.13 REN INS AGT ACE
5 11.98 VCAM1 PLAT NOS3 EDN1
6 11.9 TNNI3 APOE APOA1 ALB
7
Show member pathways
11.85 LPA APOE APOB APOA1
8 11.78 VCAM1 TNNI3 INS IL6 ALB
9
Show member pathways
11.77 APOE APOB APOA1 ALB
10 11.74 NOS3 INS IL6 EDN1
11
Show member pathways
11.69 IL6 CRP AGT
12
Show member pathways
11.61 PLG PLAT INS IL6 CRP APOE
13 11.55 VCAM1 NOS3 IL6 EDN1 AGTR1
14 11.46 REN AGTR1 AGT ACE
15 11.38 INS APOA1 ALB
16 11.27 MIR126 EDN1 APOE
17 11.25 VCAM1 IL6 APOA1
18 11.03 PLG PLAT LPA IL6 APOB
19 10.91 PLG PLAT ACE
20 10.71 PLG PLAT

GO Terms for Arteries, Anomalies of

Cellular components related to Arteries, Anomalies of according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 early endosome GO:0005769 9.81 VCAM1 APOE APOB APOA1
2 extracellular region GO:0005576 9.8 REN PLG PLAT LPA INS IL6
3 endoplasmic reticulum lumen GO:0005788 9.73 INS IL6 APOE APOB APOA1 ALB
4 blood microparticle GO:0072562 9.72 PLG APOE APOA1 ALB AGT
5 apical part of cell GO:0045177 9.7 VCAM1 REN PLAT
6 very-low-density lipoprotein particle GO:0034361 9.63 APOE APOB APOA1
7 endocytic vesicle lumen GO:0071682 9.61 APOE APOB APOA1
8 low-density lipoprotein particle GO:0034362 9.58 APOE APOB APOA1
9 chylomicron GO:0042627 9.54 APOE APOB APOA1
10 extracellular space GO:0005615 9.5 VCAM1 REN PLG PLAT MIR126 INS
11 discoidal high-density lipoprotein particle GO:0034365 9.48 APOE APOA1
12 intermediate-density lipoprotein particle GO:0034363 9.33 APOE APOB APOA1
13 extracellular exosome GO:0070062 10.15 VCAM1 PLG PLAT APOE APOB APOA1

Biological processes related to Arteries, Anomalies of according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Name GO ID Score Top Affiliating Genes
1 receptor-mediated endocytosis GO:0006898 9.99 APOE APOB APOA1 ALB
2 lipid transport GO:0006869 9.94 LPA APOE APOB APOA1
3 kidney development GO:0001822 9.91 REN AGTR1 AGT ACE
4 cholesterol homeostasis GO:0042632 9.9 APOE APOB APOA1
5 cholesterol metabolic process GO:0008203 9.89 APOE APOB APOA1
6 response to lipopolysaccharide GO:0032496 9.89 VCAM1 REN NOS3 EDN1 APOB
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.88 MIR126 INS AGT
8 retinoid metabolic process GO:0001523 9.85 APOE APOB APOA1
9 acute-phase response GO:0006953 9.81 INS IL6 CRP
10 blood vessel remodeling GO:0001974 9.79 NOS3 AGT ACE
11 triglyceride catabolic process GO:0019433 9.78 APOE APOB APOA1
12 lipoprotein metabolic process GO:0042157 9.77 APOE APOB APOA1
13 cholesterol efflux GO:0033344 9.76 APOE APOB APOA1
14 vasodilation GO:0042311 9.75 NOS3 APOE AGT
15 regulation of blood vessel size GO:0050880 9.74 NOS3 EDN1 AGT
16 regulation of blood vessel diameter GO:0097746 9.73 AGTR1 ACE
17 nitric oxide mediated signal transduction GO:0007263 9.73 NOS3 APOE AGT
18 positive regulation of renal sodium excretion GO:0035815 9.72 EDN1 AGT
19 amyloid-beta metabolic process GO:0050435 9.72 REN ACE
20 high-density lipoprotein particle assembly GO:0034380 9.72 APOE APOA1
21 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.72 APOB AGTR1 AGT
22 phospholipid efflux GO:0033700 9.71 APOE APOA1
23 angiotensin maturation GO:0002003 9.71 REN ACE
24 negative regulation of blood vessel diameter GO:0097756 9.71 INS CRP
25 high-density lipoprotein particle clearance GO:0034384 9.71 APOE APOA1
26 artery smooth muscle contraction GO:0014824 9.71 EDN1 AGT
27 positive regulation of lipid biosynthetic process GO:0046889 9.71 INS APOE APOA1
28 very-low-density lipoprotein particle remodeling GO:0034372 9.7 APOE APOA1
29 negative regulation of platelet activation GO:0010544 9.7 NOS3 APOE
30 negative regulation of lipid storage GO:0010888 9.7 IL6 CRP
31 positive regulation of cellular protein metabolic process GO:0032270 9.7 INS AGTR1 AGT
32 cellular protein metabolic process GO:0044267 9.7 PLG INS IL6 APOE APOB APOA1
33 neutrophil mediated immunity GO:0002446 9.69 IL6 ACE
34 chylomicron remnant clearance GO:0034382 9.69 APOE APOB
35 high-density lipoprotein particle remodeling GO:0034375 9.69 APOE APOA1 ALB
36 regulation of cholesterol transport GO:0032374 9.68 APOE APOA1
37 regulation of Cdc42 protein signal transduction GO:0032489 9.68 APOE APOA1
38 positive regulation of NAD(P)H oxidase activity GO:0033864 9.68 AGTR1 AGT
39 negative regulation of hydrolase activity GO:0051346 9.67 NOS3 APOA1
40 very-low-density lipoprotein particle clearance GO:0034447 9.67 APOE APOB
41 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.66 NOS3 EDN1
42 negative regulation of cellular protein metabolic process GO:0032269 9.66 EDN1 APOE
43 regulation of renal sodium excretion GO:0035813 9.65 AGTR1 AGT
44 positive regulation of dendritic spine maintenance GO:1902952 9.65 INS APOE
45 chylomicron assembly GO:0034378 9.65 APOE APOB APOA1
46 regulation of blood pressure GO:0008217 9.65 REN NOS3 EDN1 AGT ACE
47 regulation of blood volume by renin-angiotensin GO:0002016 9.63 REN AGT
48 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.63 AGTR1 AGT
49 chylomicron remodeling GO:0034371 9.63 APOE APOB APOA1
50 lipoprotein catabolic process GO:0042159 9.62 APOE APOB

Molecular functions related to Arteries, Anomalies of according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.85 REN PLG PLAT LPA ACE
2 endopeptidase activity GO:0004175 9.61 REN PLG ACE
3 lipid transporter activity GO:0005319 9.43 APOE APOB APOA1
4 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.37 APOE APOA1
5 lipoprotein particle binding GO:0071813 9.32 APOE APOA1
6 bradykinin receptor binding GO:0031711 9.16 AGTR1 ACE
7 low-density lipoprotein particle receptor binding GO:0050750 9.13 CRP APOE APOB
8 cholesterol transporter activity GO:0017127 8.8 APOE APOB APOA1
9 protein binding GO:0005515 10.33 TNNI3 REN PLG PLAT NOS3 LPA

Sources for Arteries, Anomalies of

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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