MCID: ART010
MIFTS: 37

Arteriolosclerosis

Categories: Cardiovascular diseases

Aliases & Classifications for Arteriolosclerosis

MalaCards integrated aliases for Arteriolosclerosis:

Name: Arteriolosclerosis 12 54 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5162
MeSH 44 D050379
NCIt 50 C35543
SNOMED-CT 67 17941002
ICD10 32 I70
UMLS 70 C0878486

Summaries for Arteriolosclerosis

Disease Ontology : 12 An arteriosclerosis that is characterized by thickening of the wall of the small arteries and arterioles, caused by deposition of hyaline material in the wall or concentric smooth muscle wall hypertrophy, and results in lumen narrowing and tissue ischemia.

MalaCards based summary : Arteriolosclerosis is related to glomerular disease and carotid stenosis. An important gene associated with Arteriolosclerosis is C3 (Complement C3), and among its related pathways/superpathways are Neuroscience and Alzheimers Disease. Affiliated tissues include smooth muscle, heart and kidney, and related phenotypes are behavior/neurological and cellular

Wikipedia : 73 Arteriolosclerosis is a form of cardiovascular disease involving hardening and loss of elasticity of... more...

Related Diseases for Arteriolosclerosis

Diseases related to Arteriolosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 203)
# Related Disease Score Top Affiliating Genes
1 glomerular disease 30.2 CD79A ALB
2 carotid stenosis 30.1 REN APOE ADIPOQ
3 mild cognitive impairment 30.0 MAPT APP APOE
4 iga glomerulonephritis 30.0 REN CD79A C3 ALB
5 chronic kidney disease 29.9 SERPINA3 REN APOE ALB ADIPOQ
6 end stage renal disease 29.7 REN C3 ALB ADIPOQ
7 cerebral amyloid angiopathy, cst3-related 29.6 SNCA SERPINA3 PHF1 MAPT APP APOE
8 hypertension, essential 29.4 SERPINA3 REN C3 APOE ALB ADIPOQ
9 vascular dementia 29.3 SERPINA3 NOTCH3 MAPT APP APOE
10 kidney disease 29.3 SERPINA3 REN CD79A C3 APOE ALB
11 alzheimer disease 29.3 TARDBP SNCA SERPINA3 REN MAPT APP
12 cerebrovascular disease 28.9 SERPINA3 REN NOTCH3 MAPT APP APOE
13 dementia 28.5 TMEM106B TARDBP SNCA SERPINA3 NOTCH3 MAPT
14 arteriosclerosis 10.3
15 gastrointestinal lymphoma 10.3 SERPINA3 CD79A
16 subjective cognitive decline 10.3 MAPT APOE
17 posterior cortical atrophy 10.3 MAPT APOE
18 residual stage of open angle glaucoma 10.3 APP APOE
19 hyperlipidemia, familial combined, 3 10.3 C3 APOE ADIPOQ
20 degeneration of macula and posterior pole 10.3 SERPINA3 C3 APOE
21 alzheimer disease 10 10.3 MAPT APOE
22 senile plaque formation 10.3 APP APOE
23 gerstmann syndrome 10.3 MAPT APOE
24 visual agnosia 10.2 MAPT APOE
25 placenta disease 10.2 SERPINA3 REN ADIPOQ
26 associative agnosia 10.2 TARDBP MAPT
27 progressive non-fluent aphasia 10.2 TMEM106B MAPT
28 alzheimer's disease 1 10.2 APP APOE
29 intrahepatic gall duct cancer 10.2 ALB ADIPOQ
30 familial lcat deficiency 10.2 APOE ALB
31 pica disease 10.2 TARDBP MAPT
32 pediatric systemic lupus erythematosus 10.2 C3 ADIPOQ
33 epidermolysis bullosa dystrophica, autosomal dominant 10.2 C3 ALB
34 orthostatic proteinuria 10.2 REN ALB
35 age-related hearing loss 10.2 MAPT APOE
36 alzheimer disease 18 10.2 SNCA APP
37 prosopagnosia 10.2 TARDBP MAPT
38 aspiration pneumonitis 10.2 SERPINA3 ALB
39 heavy chain disease 10.2 SERPINA3 CD79A
40 dysgraphia 10.2 TARDBP MAPT
41 hypertensive encephalopathy 10.2 REN ALB
42 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.2
43 cerebral amyloid angiopathy, app-related 10.1 SERPINA3 APP APOE
44 kidney papillary necrosis 10.1 REN ALB
45 benign essential hypertension 10.1 REN ALB
46 coenzyme q10 deficiency, primary, 1 10.1 SNCA MAPT
47 simultanagnosia 10.1 TARDBP MAPT APOE
48 writing disorder 10.1 TARDBP MAPT
49 nominal aphasia 10.1 TARDBP MAPT APOE
50 alexia 10.1 TARDBP MAPT APOE

Graphical network of the top 20 diseases related to Arteriolosclerosis:



Diseases related to Arteriolosclerosis

Symptoms & Phenotypes for Arteriolosclerosis

MGI Mouse Phenotypes related to Arteriolosclerosis:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.32 ABCC9 ADIPOQ APOE APP C3 CPLX1
2 cellular MP:0005384 10.29 ABCC9 ADIPOQ ALB APOE APP C3
3 homeostasis/metabolism MP:0005376 10.25 ABCC9 ADIPOQ ALB APOE APP C3
4 growth/size/body region MP:0005378 10.23 ABCC9 ADIPOQ APOE APP C3 CPLX1
5 cardiovascular system MP:0005385 10.19 ABCC9 ADIPOQ ALB APOE APP C3
6 hematopoietic system MP:0005397 10.17 ADIPOQ APOE APP C3 CD79A MAPT
7 immune system MP:0005387 10.15 ADIPOQ ALB APOE APP C3 CD79A
8 mortality/aging MP:0010768 10.13 ABCC9 ADIPOQ ALB APOE APP C3
9 muscle MP:0005369 10 ABCC9 ADIPOQ ALB APOE APP C3
10 nervous system MP:0003631 9.97 ABCC9 ADIPOQ APOE APP C3 CD79A
11 normal MP:0002873 9.56 ALB APP C3 CD79A MAPT NOTCH3
12 renal/urinary system MP:0005367 9.28 ADIPOQ ALB APOE C3 CD79A MAPT

Drugs & Therapeutics for Arteriolosclerosis

Search Clinical Trials , NIH Clinical Center for Arteriolosclerosis

Cochrane evidence based reviews: arteriolosclerosis

Genetic Tests for Arteriolosclerosis

Anatomical Context for Arteriolosclerosis

MalaCards organs/tissues related to Arteriolosclerosis:

40
Smooth Muscle, Heart, Kidney, Eye, Brain, Endothelial, Spleen

Publications for Arteriolosclerosis

Articles related to Arteriolosclerosis:

(show top 50) (show all 464)
# Title Authors PMID Year
1
Association between serum adiponectin levels and arteriolosclerosis in IgA nephropathy patients. 61 54
17443034 2007
2
[Three-dimensional morphologic examination of normal and diseased renal arterioles]. 61 54
14686064 2003
3
Mechanism of herbal medicine on hypertensive nephropathy (Review). 61
33537809 2021
4
Adult-onset minimal change disease: the significance of histological chronic changes for clinical presentation and outcome. 61
33090339 2021
5
Aβ (Amyloid Beta) and Tau Tangle Pathology Modifies the Association Between Small Vessel Disease and Cortical Microinfarcts. 61
33567873 2021
6
Pontine Arteriolosclerosis and Locus Coeruleus Oxidative Stress Differentiate Resilience from Mild Cognitive Impairment in a Clinical Pathologic Cohort. 61
33709107 2021
7
To what degree is late life cognitive decline driven by age-relatedneuropathologies? 61
33742668 2021
8
Person-Specific Contributions of Brain Pathologies to Progressive Parkinsonism in Older Adults. 61
32720690 2021
9
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change and microvascular pathologies in community-dwelling older persons. 61
33624322 2021
10
Successful improved peripheral tissue perfusion was seen in patients with atherosclerosis after 12 months of treatment with aged garlic extract. 61
33590955 2021
11
Clinical, histopathologic and molecular features of idiopathic and diabetic nodular mesangial sclerosis in humans. 61
33537765 2021
12
Neurobiology of COVID-19: how can the virus affect the brain? 61
33605367 2021
13
Neuropathologic Findings in Chronic Kidney Disease (CKD). 61
33579545 2021
14
Brain arteriolosclerosis. 61
33098484 2021
15
MarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols. 61
33480172 2021
16
Clinical Profiles of Arteriolosclerosis and Alzheimer Disease at Mild Cognitive Impairment and Mild Dementia in a National Neuropathology Cohort. 61
32925200 2021
17
Mediators of cerebral hypoperfusion and blood-brain barrier leakiness in Alzheimer's disease, vascular dementia and mixed dementia. 61
33410232 2021
18
Perivascular macrophages produce type I collagen around cerebral small vessels under prolonged hypertension in rats. 61
33398434 2021
19
A Simplified Brain Blocking Protocol Optimized for the Diagnosis of Neurodegenerative Disease Saves Time and Money While Preserving Anatomic Relationships. 61
33290509 2020
20
Neuropathologic burden and the degree of frailty in relation to global cognition and dementia. 61
32989103 2020
21
Pharmacological inhibition of fatty acid-binding protein 4 alleviated kidney inflammation and fibrosis in hyperuricemic nephropathy. 61
32949603 2020
22
Vascular disease and multiple sclerosis: a post-mortem study exploring their relationships. 61
32875311 2020
23
Stroke: causes and clinical features. 61
32837228 2020
24
Novel FEMASK-score, a histopathologic assessment for destructive Charcot neuropathic arthropathy, reveals intraneural vasculopathy and correlates with progression and best treatment. 61
32619921 2020
25
Early and Sequential Punch Grafting in the Spectrum of Arteriolopathy Ulcers in the Elderly. 61
33166269 2020
26
The Neuropathology of Chronic Traumatic Encephalopathy: The Status of the Literature. 61
32712946 2020
27
Peripheral arterial stiffness is correlated with intrarenal arteriolosclerosis according to biopsies from patients with kidney disease. 61
31576636 2020
28
Premature vascular disease in young adult stroke: a pathology-based case series. 61
31853711 2020
29
Relationship between androgenic alopecia and white matter hyperintensities in apparently healthy subjects. 61
31250269 2020
30
Limbic Predominant Age-Related TDP-43 Encephalopathy (LATE): Clinical and Neuropathological Associations. 61
31845964 2020
31
Podocyte-targeted Heme Oxygenase (HO)-1 overexpression exacerbates age-related pathology in the rat kidney. 61
32235880 2020
32
Renal Damages in Deoxycorticosterone Acetate-Salt Hypertensive Rats: Assessment with Diffusion Tensor Imaging and T2-mapping. 61
31065896 2020
33
Neuropathologic Correlates of White Matter Hyperintensities in a Community-Based Cohort of Older Adults. 61
31771057 2020
34
Clinical Features and Experimental Models of Cerebral Small Vessel Disease. 61
32431603 2020
35
Preoperative Comorbidities and Outcomes of Medically Complex Living Kidney Donors. 61
31922057 2020
36
Small vessel disease pathological changes in neurodegenerative and vascular dementias concomitant with autonomic dysfunction. 61
31357238 2020
37
Pathogenetic pathways of cognitive dysfunction and dementia in metabolic syndrome. 61
31606384 2019
38
Common age-related neuropathologies and yearly variability in cognition. 61
31568713 2019
39
Intrarenal resistive index conundrum: systemic atherosclerosis versus renal arteriolosclerosis. 61
31599199 2019
40
A Novel Association of Martorell Ulcer With Liddle Syndrome. 61
31625969 2019
41
Neuropathological lesions in the very old: results from a large Brazilian autopsy study. 61
30861605 2019
42
Genome-wide association study of cerebral small vessel disease reveals established and novel loci. 61
31430377 2019
43
[Development of arteriosclerosis]. 61
31435781 2019
44
Hyaline Arteriolosclerosis in 30 Strains of Aged Inbred Mice. 61
31060453 2019
45
Neuropsychological latent classes at enrollment and postmortem neuropathology. 61
31420203 2019
46
Association of White Matter Rarefaction, Arteriolosclerosis, and Tau With Dementia in Chronic Traumatic Encephalopathy. 61
31380975 2019
47
Localization, Morphologic Features, and Chemical Composition of Calciphylaxis-Related Skin Deposits in Patients With Calcific Uremic Arteriolopathy. 61
31116362 2019
48
Prediction of Acute Glomerular Filtration Rate Reductions Following Renin-angiotensin System Blockade in Chronic Kidney Disease: A Possible Application of Ultrasonography in Clinical Practice. 61
30626816 2019
49
Extravascular fibrinogen in the white matter of Alzheimer's disease and normal aged brains: implications for fibrinogen as a biomarker for Alzheimer's disease. 61
30485582 2019
50
Pathologic glomerular characteristics and glomerular basement membrane alterations in biopsy-proven thin basement membrane nephropathy. 61
30687875 2019

Variations for Arteriolosclerosis

Expression for Arteriolosclerosis

Search GEO for disease gene expression data for Arteriolosclerosis.

Pathways for Arteriolosclerosis

Pathways related to Arteriolosclerosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.7 TARDBP SNCA NOTCH3 MAPT CPLX1 APP
2 11.43 SNCA MAPT APP APOE
3 10.99 MAPT APP APOE

GO Terms for Arteriolosclerosis

Cellular components related to Arteriolosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.92 SNCA SERPINA3 REN C3 APP APOE
2 endoplasmic reticulum lumen GO:0005788 9.67 C3 APP APOE ALB
3 platelet alpha granule lumen GO:0031093 9.43 SERPINA3 APP ALB
4 extracellular region GO:0005576 9.32 SNCA SERPINA3 REN NOTCH3 MAPT C3
5 blood microparticle GO:0072562 9.26 SERPINA3 C3 APOE ALB
6 main axon GO:0044304 9.16 MAPT APP

Biological processes related to Arteriolosclerosis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.83 TARDBP MAPT APP APOE
2 regulation of long-term neuronal synaptic plasticity GO:0048169 9.57 SNCA APP
3 regulation of neuronal synaptic plasticity GO:0048168 9.56 SNCA APOE
4 high-density lipoprotein particle remodeling GO:0034375 9.55 APOE ALB
5 astrocyte activation GO:0048143 9.54 MAPT APP
6 negative regulation of long-term synaptic potentiation GO:1900272 9.51 APP APOE
7 synapse organization GO:0050808 9.5 SNCA MAPT APP
8 supramolecular fiber organization GO:0097435 9.49 SNCA MAPT
9 cellular response to epinephrine stimulus GO:0071872 9.48 SNCA ADIPOQ
10 amyloid fibril formation GO:1990000 9.46 MAPT APP
11 neuron remodeling GO:0016322 9.43 C3 APP
12 negative regulation of low-density lipoprotein receptor activity GO:1905598 9.4 APP ADIPOQ
13 negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642 9.37 SNCA ADIPOQ
14 gene expression GO:0010467 9.33 TARDBP APOE ADIPOQ
15 positive regulation of amyloid fibril formation GO:1905908 9.26 APP APOE
16 microglial cell activation GO:0001774 9.13 SNCA MAPT APP
17 cellular protein metabolic process GO:0044267 9.02 SNCA C3 APP APOE ALB

Molecular functions related to Arteriolosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.35 REN C3 APP APOE ADIPOQ
2 identical protein binding GO:0042802 9.32 TARDBP SNCA PHF1 NOTCH3 MAPT CD79A
3 lipoprotein particle binding GO:0071813 9.16 MAPT APOE

Sources for Arteriolosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....