MCID: ART010
MIFTS: 31

Arteriolosclerosis

Categories: Cardiovascular diseases

Aliases & Classifications for Arteriolosclerosis

MalaCards integrated aliases for Arteriolosclerosis:

Name: Arteriolosclerosis 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5162
ICD10 33 I70
MeSH 44 D050379
NCIt 50 C35543
SNOMED-CT 68 17941002
UMLS 73 C0878486

Summaries for Arteriolosclerosis

MalaCards based summary : Arteriolosclerosis is related to iga glomerulonephritis and kidney disease. An important gene associated with Arteriolosclerosis is C3 (Complement C3). Affiliated tissues include brain, kidney and heart, and related phenotypes are growth/size/body region and cardiovascular system

Wikipedia : 76 Arteriolosclerosis is a form of cardiovascular disease involving hardening and loss of elasticity of... more...

Related Diseases for Arteriolosclerosis

Diseases related to Arteriolosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 iga glomerulonephritis 30.0 CD79A REN
2 kidney disease 29.8 ADIPOQ APOE C3 REN
3 dementia 29.6 APOE HTRA1 TARDBP
4 chronic kidney failure 10.2
5 dysbaric osteonecrosis 10.2 ADIPOQ C3
6 hypersensitivity vasculitis 10.1 C3 CD79A
7 hypersensitivity reaction type iii disease 10.1 C3 CD79A
8 henoch-schoenlein purpura 10.1 C3 CD79A
9 proliferative glomerulonephritis 10.1 C3 CD79A
10 membranoproliferative glomerulonephritis 10.1 C3 CD79A
11 cantu syndrome 10.1 ABCC9 TARDBP
12 hypertension, essential 10.1
13 focal segmental glomerulosclerosis 1 10.1
14 hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy 10.1
15 focal segmental glomerulosclerosis 10.1
16 ischemia 10.1
17 alexia 10.1 APOE TARDBP
18 degeneration of macula and posterior pole 10.1 C3 HTRA1
19 semantic dementia 10.0 APOE TARDBP
20 membranous nephropathy 10.0 C3 CD79A
21 lipid metabolism disorder 10.0 ADIPOQ APOE
22 pick disease of brain 10.0 APOE TARDBP
23 orthostatic proteinuria 10.0 C3 REN
24 inclusion body myositis 10.0 APOE TARDBP
25 supranuclear palsy, progressive, 1 10.0 APOE TARDBP
26 hypertensive retinopathy 10.0 ADIPOQ REN
27 apnea, obstructive sleep 10.0 ADIPOQ REN
28 dementia, lewy body 10.0 APOE TARDBP
29 renal tuberculosis 10.0 CD79A REN
30 speech and communication disorders 9.9 APOE TARDBP
31 diabetes mellitus 9.9
32 glomerulonephritis 9.9
33 heart disease 9.9
34 hypertensive heart disease 9.9
35 hyperglycemia 9.9
36 pyoderma 9.9
37 pyoderma gangrenosum 9.9
38 vascular dementia 9.9
39 glucose metabolism disease 9.9 ADIPOQ REN
40 disease of mental health 9.9 APOE TARDBP
41 carotid artery disease 9.9 APOE REN
42 aortic disease 9.9 APOE REN
43 macular degeneration, age-related, 1 9.9 APOE C3 HTRA1
44 acquired metabolic disease 9.9 ADIPOQ REN
45 atherosclerosis susceptibility 9.8 ADIPOQ APOE
46 sleep apnea 9.8 ADIPOQ APOE REN
47 arteries, anomalies of 9.8 ADIPOQ APOE REN
48 cerebrovascular disease 9.8 ADIPOQ APOE REN
49 vascular disease 9.8 ADIPOQ APOE REN
50 body mass index quantitative trait locus 11 9.8 ADIPOQ APOE C3

Graphical network of the top 20 diseases related to Arteriolosclerosis:



Diseases related to Arteriolosclerosis

Symptoms & Phenotypes for Arteriolosclerosis

MGI Mouse Phenotypes related to Arteriolosclerosis:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.98 ABCC9 ADIPOQ APOE C3 HTRA1 REN
2 cardiovascular system MP:0005385 9.95 ABCC9 ADIPOQ APOE C3 HTRA1 REN
3 cellular MP:0005384 9.93 ABCC9 ADIPOQ APOE C3 CD79A TARDBP
4 homeostasis/metabolism MP:0005376 9.91 ABCC9 ADIPOQ APOE C3 CD79A REN
5 hematopoietic system MP:0005397 9.88 ADIPOQ APOE C3 CD79A REN TARDBP
6 adipose tissue MP:0005375 9.8 ADIPOQ APOE C3 TARDBP
7 immune system MP:0005387 9.8 ADIPOQ APOE C3 CD79A REN TARDBP
8 muscle MP:0005369 9.73 ABCC9 ADIPOQ APOE C3 REN TARDBP
9 nervous system MP:0003631 9.63 ADIPOQ APOE C3 CD79A REN TARDBP
10 renal/urinary system MP:0005367 9.35 ADIPOQ APOE C3 CD79A REN
11 skeleton MP:0005390 9.02 ADIPOQ APOE C3 HTRA1 TARDBP

Drugs & Therapeutics for Arteriolosclerosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pathophysiology of Martorell Hypertensive Ischemic Leg Ulcer (HYTILU) Unknown status NCT01578382

Search NIH Clinical Center for Arteriolosclerosis

Cochrane evidence based reviews: arteriolosclerosis

Genetic Tests for Arteriolosclerosis

Anatomical Context for Arteriolosclerosis

MalaCards organs/tissues related to Arteriolosclerosis:

41
Brain, Kidney, Heart, Spleen

Publications for Arteriolosclerosis

Articles related to Arteriolosclerosis:

(show top 50) (show all 66)
# Title Authors Year
1
A case of chronic ulcer due to subcutaneous arteriolosclerosis in an obese patient mimicking pyoderma gangrenosum. ( 29887980 )
2018
2
Cutaneous Arteriolosclerosis Is Not Specific to Ischemic Hypertensive Leg Ulcers. ( 30199871 )
2018
3
Spinal Arteriolosclerosis Is Common in Older Adults and Associated With Parkinsonism. ( 28931619 )
2017
4
Long-term treatment with chaethomellic acid A reduces glomerulosclerosis and arteriolosclerosis in a rat model of chronic kidney disease. ( 29032332 )
2017
5
Relationship Between Type of Hypertension and Renal Arteriolosclerosis in Chronic Glomerular Disease. ( 27327274 )
2016
6
Letter by Kawada Regarding Article, "Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People". ( 27118795 )
2016
7
Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People. ( 26768207 )
2016
8
Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals. ( 26738751 )
2016
9
Response to Letter Regarding Article, "Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People". ( 27118794 )
2016
10
Hepatic Arteriolosclerosis: A Small-vessel Complication of Diabetes and Hypertension. ( 25786083 )
2015
11
Relationship between vascular function indexes, renal arteriolosclerosis, and renal clinical outcomes in chronic kidney disease. ( 25854541 )
2015
12
Blood-brain barrier dysfunction and cerebral small vessel disease (arteriolosclerosis) in brains of older people. ( 25289893 )
2014
13
Large blood pressure variability aggravates arteriolosclerosis and cortical sclerotic changes in the kidney in hypertensive rats. ( 24976508 )
2014
14
Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing. ( 24271328 )
2014
15
C3d deposition in the media of renal arterioles is a useful marker for arteriolosclerosis in IgA nephropathy. ( 24480433 )
2014
16
Genetic susceptibility for ischemic infarction and arteriolosclerosis based on neuropathologic evaluations. ( 24135527 )
2013
17
Serum complement C3 predicts renal arteriolosclerosis in non-diabetic chronic kidney disease. ( 22863782 )
2012
18
Stroke patients with cerebral microbleeds on MRI scans have arteriolosclerosis as well as systemic atherosclerosis. ( 22739424 )
2012
19
Severe intra- and periventricular hemorrhage: role of arteriolosclerosis related to maternal smoke. ( 21744137 )
2011
20
Postprandial hyperglycemia and hyperinsulinemia associated with renal arterio-arteriolosclerosis in chronic kidney disease. ( 20186145 )
2010
21
Martorell hypertensive ischemic leg ulcer: a model of ischemic subcutaneous arteriolosclerosis. ( 20855694 )
2010
22
Association between serum adiponectin levels and arteriolosclerosis in IgA nephropathy patients. ( 17443034 )
2007
23
Hyaline arteriolosclerosis: new meaning for an old lesion. ( 12631104 )
2003
24
Significance of white matter high intensity lesions as a predictor of stroke from arteriolosclerosis. ( 11971040 )
2002
25
Clinical picture of arteriolosclerosis. ( 11725387 )
2001
26
A clinical investigation on 30 cases of senile benign renal arteriolosclerosis treated by huang qi gu jing yin. ( 11789320 )
2001
27
Coronary reserve and arteriolosclerosis in hypertensive heart disease. ( 11151783 )
2000
28
Adverse effect of donor arteriolosclerosis on graft outcome after renal transplantation. ( 10809815 )
2000
29
Super long-term surviving two renal grafts with severe arteriolosclerosis and glomerulosclerosis. ( 11092352 )
2000
30
Severe renal arterio-arteriolosclerosis after cocaine use. ( 10069205 )
1999
31
Brain arteriolosclerosis and hemodynamic disturbance may induce leukoaraiosis. ( 10563635 )
1999
32
Diffuse vacuolization (spongiosis) and arteriolosclerosis in the frontal white matter occurs in vascular dementia. ( 8929154 )
1996
33
Decrease of urine protein after treatment with probucol in patients with mild glomerulonephritis and arteriolosclerosis. ( 7477633 )
1995
34
Spontaneous coronary arteriolosclerosis in broiler chickens. ( 8357921 )
1993
35
Myoendothelial contacts in arteriolosclerosis. ( 1635004 )
1992
36
Periventricular lesions in the white matter on magnetic resonance imaging in the elderly. A morphometric correlation with arteriolosclerosis and dilated perivascular spaces. ( 2043948 )
1991
37
Arteriolosclerosis of the human renal allograft: morphology, origin, life history and relationship to cyclosporine therapy. ( 1899956 )
1991
38
Significance of renal hyaline arteriolosclerosis and tubulo-interstitial change in IgA glomerulonephropathy and focal glomerular sclerosis. ( 3696327 )
1987
39
Arteriolosclerosis in a cat. ( 3672816 )
1987
40
The pathogenesis of hyaline arteriolosclerosis. ( 2420184 )
1986
41
Renal hyaline arteriolosclerosis in focal segmental glomerulosclerosis. ( 3736745 )
1986
42
Significance of renal hyaline arteriolosclerosis in focal segmental glomerulosclerosis. ( 3897888 )
1985
43
The distribution of arteriolosclerosis along the arterioles in DOCA hypertensive rats. ( 6627747 )
1983
44
Histophysical and histochemical investigations on muscle arterioles in hypertensive arteriolosclerosis; an interference microscopical, polarization optical and histophotometrical study. ( 104533 )
1978
45
The size of the juxtaglomerular apparatus in diabetic glomerulosclerosis and its correlation with arteriolosclerosis and arterial hypertension: a morphometric light microscopic study on human renal biopsies. ( 884912 )
1977
46
Quantitative studies of the renal corpuscles IV. Determination of normal values in various age categories, and an analysis of the possible influence of physiological degrees of arteriolosclerosis. ( 878873 )
1977
47
Hyaline arteriolosclerosis in wild animals. ( 4194799 )
1970
48
The quantitative appraisal of coronary vascular lesions in experimental hypertension and hypercholesterolemia with special reference to intramural arteriolosclerosis. ( 5304324 )
1968
49
Hypertension with arteriolosclerosis in childhood: report of two cases. ( 6043880 )
1967
50
Retinal arteriolosclerosis in age, essential hypertension, and diabetes mellitus. ( 5964940 )
1966

Variations for Arteriolosclerosis

Expression for Arteriolosclerosis

Search GEO for disease gene expression data for Arteriolosclerosis.

Pathways for Arteriolosclerosis

GO Terms for Arteriolosclerosis

Cellular components related to Arteriolosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.55 ADIPOQ APOE C3 HTRA1 REN
2 extracellular space GO:0005615 9.35 ADIPOQ APOE C3 HTRA1 REN
3 collagen-containing extracellular matrix GO:0062023 8.8 ADIPOQ APOE HTRA1

Biological processes related to Arteriolosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.33 ABCC9 ADIPOQ REN
2 cellular response to drug GO:0035690 9.26 ADIPOQ REN
3 negative regulation of MAP kinase activity GO:0043407 8.96 ADIPOQ APOE
4 positive regulation of cholesterol efflux GO:0010875 8.62 ADIPOQ APOE

Molecular functions related to Arteriolosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.13 ADIPOQ C3 REN
2 identical protein binding GO:0042802 8.92 ADIPOQ APOE HTRA1 TARDBP

Sources for Arteriolosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....