MCID: ART010
MIFTS: 29

Arteriolosclerosis

Categories: Cardiovascular diseases

Aliases & Classifications for Arteriolosclerosis

MalaCards integrated aliases for Arteriolosclerosis:

Name: Arteriolosclerosis 12 56 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5162
MeSH 45 D050379
NCIt 51 C35543
SNOMED-CT 69 17941002
ICD10 34 I70
UMLS 74 C0878486

Summaries for Arteriolosclerosis

MalaCards based summary : Arteriolosclerosis is related to iga glomerulonephritis and kidney disease. An important gene associated with Arteriolosclerosis is C3 (Complement C3). Affiliated tissues include kidney, heart and brain, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 77 Arteriolosclerosis is a form of cardiovascular disease involving hardening and loss of elasticity of... more...

Related Diseases for Arteriolosclerosis

Diseases related to Arteriolosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 iga glomerulonephritis 30.1 CD79A REN
2 kidney disease 29.1 ADIPOQ APOE C3 CABIN1 REN
3 chronic kidney failure 10.3
4 dysbaric osteonecrosis 10.2 ADIPOQ C3
5 hypersensitivity vasculitis 10.2 C3 CD79A
6 hypersensitivity reaction type iii disease 10.2 C3 CD79A
7 henoch-schoenlein purpura 10.2 C3 CD79A
8 proliferative glomerulonephritis 10.2 C3 CD79A
9 membranoproliferative glomerulonephritis 10.1 C3 CD79A
10 degeneration of macula and posterior pole 10.1 C3 HTRA1
11 hypertension, essential 10.1
12 focal segmental glomerulosclerosis 1 10.1
13 hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy 10.1
14 focal segmental glomerulosclerosis 10.1
15 ischemia 10.1
16 orthostatic proteinuria 10.1 C3 REN
17 hypertensive retinopathy 10.1 ADIPOQ REN
18 hemolytic-uremic syndrome 10.1 C3 CABIN1
19 membranous nephropathy 10.1 C3 CD79A
20 apnea, obstructive sleep 10.0 ADIPOQ REN
21 renal tuberculosis 10.0 CD79A REN
22 diabetes mellitus 10.0
23 glomerulonephritis 10.0
24 heart disease 10.0
25 hypertensive heart disease 10.0
26 dementia 10.0
27 hyperinsulinism 10.0
28 hyperglycemia 10.0
29 pyoderma 10.0
30 pyoderma gangrenosum 10.0
31 vascular dementia 10.0
32 glucose metabolism disease 10.0 ADIPOQ REN
33 acquired metabolic disease 9.9 ADIPOQ REN
34 lipid metabolism disorder 9.9 ADIPOQ APOE
35 urinary system disease 9.8 CABIN1 REN
36 carotid artery disease 9.8 APOE REN
37 aortic disease 9.8 APOE REN
38 macular degeneration, age-related, 1 9.7 APOE C3 HTRA1
39 sleep apnea 9.6 ADIPOQ APOE REN
40 arteries, anomalies of 9.6 ADIPOQ APOE REN
41 cerebrovascular disease 9.6 ADIPOQ APOE REN
42 vascular disease 9.6 ADIPOQ APOE REN
43 atherosclerosis susceptibility 9.6 ADIPOQ APOE
44 body mass index quantitative trait locus 11 9.5 ADIPOQ APOE C3
45 myocardial infarction 9.4 ABCC9 ADIPOQ APOE REN

Graphical network of the top 20 diseases related to Arteriolosclerosis:



Diseases related to Arteriolosclerosis

Symptoms & Phenotypes for Arteriolosclerosis

MGI Mouse Phenotypes related to Arteriolosclerosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 ABCC9 ADIPOQ APOE C3 HTRA1 REN
2 growth/size/body region MP:0005378 9.8 ABCC9 ADIPOQ APOE C3 HTRA1 REN
3 hematopoietic system MP:0005397 9.73 ADIPOQ APOE C3 CABIN1 CD79A REN
4 immune system MP:0005387 9.63 ADIPOQ APOE C3 CABIN1 CD79A REN
5 muscle MP:0005369 9.35 ABCC9 ADIPOQ APOE C3 REN
6 renal/urinary system MP:0005367 9.02 ADIPOQ APOE C3 CD79A REN

Drugs & Therapeutics for Arteriolosclerosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pathophysiology of Martorell Hypertensive Ischemic Leg Ulcer (HYTILU) Unknown status NCT01578382

Search NIH Clinical Center for Arteriolosclerosis

Cochrane evidence based reviews: arteriolosclerosis

Genetic Tests for Arteriolosclerosis

Anatomical Context for Arteriolosclerosis

MalaCards organs/tissues related to Arteriolosclerosis:

42
Kidney, Heart, Brain, Spleen

Publications for Arteriolosclerosis

Articles related to Arteriolosclerosis:

(show top 50) (show all 67)
# Title Authors Year
1
Hyaline Arteriolosclerosis in 30 Strains of Aged Inbred Mice. ( 31060453 )
2019
2
Cutaneous Arteriolosclerosis Is Not Specific to Ischemic Hypertensive Leg Ulcers. ( 30199871 )
2018
3
A case of chronic ulcer due to subcutaneous arteriolosclerosis in an obese patient mimicking pyoderma gangrenosum. ( 29887980 )
2018
4
Long-term treatment with chaethomellic acid A reduces glomerulosclerosis and arteriolosclerosis in a rat model of chronic kidney disease. ( 29032332 )
2017
5
Spinal Arteriolosclerosis Is Common in Older Adults and Associated With Parkinsonism. ( 28931619 )
2017
6
Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals. ( 26738751 )
2017
7
Relationship Between Type of Hypertension and Renal Arteriolosclerosis in Chronic Glomerular Disease. ( 27327274 )
2016
8
Letter by Kawada Regarding Article, "Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People". ( 27118795 )
2016
9
Response to Letter Regarding Article, "Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People". ( 27118794 )
2016
10
Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People. ( 26768207 )
2016
11
Relationship between vascular function indexes, renal arteriolosclerosis, and renal clinical outcomes in chronic kidney disease. ( 25854541 )
2015
12
Hepatic arteriolosclerosis: a small-vessel complication of diabetes and hypertension. ( 25786083 )
2015
13
Blood-brain barrier dysfunction and cerebral small vessel disease (arteriolosclerosis) in brains of older people. ( 25289893 )
2014
14
Large blood pressure variability aggravates arteriolosclerosis and cortical sclerotic changes in the kidney in hypertensive rats. ( 24976508 )
2014
15
C3d deposition in the media of renal arterioles is a useful marker for arteriolosclerosis in IgA nephropathy. ( 24480433 )
2014
16
Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing. ( 24271328 )
2014
17
Genetic susceptibility for ischemic infarction and arteriolosclerosis based on neuropathologic evaluations. ( 24135527 )
2013
18
Serum complement C3 predicts renal arteriolosclerosis in non-diabetic chronic kidney disease. ( 22863782 )
2012
19
Stroke patients with cerebral microbleeds on MRI scans have arteriolosclerosis as well as systemic atherosclerosis. ( 22739424 )
2012
20
Severe intra- and periventricular hemorrhage: role of arteriolosclerosis related to maternal smoke. ( 21744137 )
2011
21
Martorell hypertensive ischemic leg ulcer: a model of ischemic subcutaneous arteriolosclerosis. ( 20855694 )
2010
22
Postprandial hyperglycemia and hyperinsulinemia associated with renal arterio-arteriolosclerosis in chronic kidney disease. ( 20186145 )
2010
23
Association between serum adiponectin levels and arteriolosclerosis in IgA nephropathy patients. ( 17443034 )
2007
24
Hyaline arteriolosclerosis: new meaning for an old lesion. ( 12631104 )
2003
25
Significance of white matter high intensity lesions as a predictor of stroke from arteriolosclerosis. ( 11971040 )
2002
26
A clinical investigation on 30 cases of senile benign renal arteriolosclerosis treated by huang qi gu jing yin. ( 11789320 )
2001
27
Clinical picture of arteriolosclerosis. ( 11725387 )
2001
28
Coronary reserve and arteriolosclerosis in hypertensive heart disease. ( 11151783 )
2000
29
Super long-term surviving two renal grafts with severe arteriolosclerosis and glomerulosclerosis. ( 11092352 )
2000
30
Adverse effect of donor arteriolosclerosis on graft outcome after renal transplantation. ( 10809815 )
2000
31
Brain arteriolosclerosis and hemodynamic disturbance may induce leukoaraiosis. ( 10563635 )
1999
32
Severe renal arterio-arteriolosclerosis after cocaine use. ( 10069205 )
1999
33
Diffuse vacuolization (spongiosis) and arteriolosclerosis in the frontal white matter occurs in vascular dementia. ( 8929154 )
1996
34
Decrease of urine protein after treatment with probucol in patients with mild glomerulonephritis and arteriolosclerosis. ( 7477633 )
1995
35
Spontaneous coronary arteriolosclerosis in broiler chickens. ( 8357921 )
1993
36
Myoendothelial contacts in arteriolosclerosis. ( 1635004 )
1992
37
Periventricular lesions in the white matter on magnetic resonance imaging in the elderly. A morphometric correlation with arteriolosclerosis and dilated perivascular spaces. ( 2043948 )
1991
38
Arteriolosclerosis of the human renal allograft: morphology, origin, life history and relationship to cyclosporine therapy. ( 1899956 )
1991
39
Significance of renal hyaline arteriolosclerosis and tubulo-interstitial change in IgA glomerulonephropathy and focal glomerular sclerosis. ( 3696327 )
1987
40
Arteriolosclerosis in a cat. ( 3672816 )
1987
41
Renal hyaline arteriolosclerosis in focal segmental glomerulosclerosis. ( 3736745 )
1986
42
The pathogenesis of hyaline arteriolosclerosis. ( 2420184 )
1986
43
Significance of renal hyaline arteriolosclerosis in focal segmental glomerulosclerosis. ( 3897888 )
1985
44
The distribution of arteriolosclerosis along the arterioles in DOCA hypertensive rats. ( 6627747 )
1983
45
Histophysical and histochemical investigations on muscle arterioles in hypertensive arteriolosclerosis; an interference microscopical, polarization optical and histophotometrical study. ( 104533 )
1978
46
The size of the juxtaglomerular apparatus in diabetic glomerulosclerosis and its correlation with arteriolosclerosis and arterial hypertension: a morphometric light microscopic study on human renal biopsies. ( 884912 )
1977
47
Quantitative studies of the renal corpuscles IV. Determination of normal values in various age categories, and an analysis of the possible influence of physiological degrees of arteriolosclerosis. ( 878873 )
1977
48
Hyaline arteriolosclerosis in wild animals. ( 4194799 )
1970
49
The quantitative appraisal of coronary vascular lesions in experimental hypertension and hypercholesterolemia with special reference to intramural arteriolosclerosis. ( 5304324 )
1968
50
Hypertension with arteriolosclerosis in childhood: report of two cases. ( 6043880 )
1967

Variations for Arteriolosclerosis

Expression for Arteriolosclerosis

Search GEO for disease gene expression data for Arteriolosclerosis.

Pathways for Arteriolosclerosis

GO Terms for Arteriolosclerosis

Cellular components related to Arteriolosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.55 ADIPOQ APOE C3 HTRA1 REN
2 extracellular space GO:0005615 9.35 ADIPOQ APOE C3 HTRA1 REN
3 collagen-containing extracellular matrix GO:0062023 8.8 ADIPOQ APOE HTRA1

Biological processes related to Arteriolosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.33 ABCC9 ADIPOQ REN
2 cellular response to drug GO:0035690 9.26 ADIPOQ REN
3 negative regulation of MAP kinase activity GO:0043407 8.96 ADIPOQ APOE
4 positive regulation of cholesterol efflux GO:0010875 8.62 ADIPOQ APOE

Molecular functions related to Arteriolosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 8.8 ADIPOQ C3 REN

Sources for Arteriolosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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