MCID: ART010
MIFTS: 34

Arteriolosclerosis

Categories: Cardiovascular diseases

Aliases & Classifications for Arteriolosclerosis

MalaCards integrated aliases for Arteriolosclerosis:

Name: Arteriolosclerosis 12 54 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5162
MeSH 43 D050379
NCIt 49 C35543
SNOMED-CT 67 17941002
ICD10 32 I70
UMLS 71 C0878486

Summaries for Arteriolosclerosis

MalaCards based summary : Arteriolosclerosis is related to carotid stenosis and glomerular disease. An important gene associated with Arteriolosclerosis is C3 (Complement C3), and among its related pathways/superpathways is Alzheimers Disease Pathway. Affiliated tissues include kidney, brain and heart, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 Arteriolosclerosis is a form of cardiovascular disease involving hardening and loss of elasticity of... more...

Related Diseases for Arteriolosclerosis

Diseases related to Arteriolosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
# Related Disease Score Top Affiliating Genes
1 carotid stenosis 30.5 REN APOE ADIPOQ
2 glomerular disease 30.4 CD79A ALB
3 iga glomerulonephritis 30.1 REN CD79A C3 ALB
4 vascular dementia 30.1 SERPINA3 MAPT APP APOE
5 chronic kidney disease 29.8 REN APOE ALB ADIPOQ
6 kidney disease 29.6 SERPINA3 REN CD79A C3 APOE ALB
7 cerebral amyloid angiopathy, cst3-related 29.5 TREX1 SERPINA3 MAPT HTRA1 APP APOE
8 dementia 28.8 TMEM106B TARDBP SERPINA3 MAPT HTRA1 APP
9 cerebrovascular disease 28.8 TREX1 SERPINA3 REN MAPT HTRA1 APP
10 arteriosclerosis 10.5
11 residual stage of open angle glaucoma 10.4 APP APOE
12 senile plaque formation 10.4 APP APOE
13 hyperlipidemia, familial combined, 3 10.4 C3 APOE ADIPOQ
14 gastrointestinal lymphoma 10.3 SERPINA3 CD79A
15 placenta disease 10.3 SERPINA3 REN ADIPOQ
16 familial lcat deficiency 10.3 APOE ALB
17 posterior cortical atrophy 10.3 MAPT APOE
18 epidermolysis bullosa dystrophica, autosomal dominant 10.3 C3 ALB
19 atherosclerosis susceptibility 10.3
20 gerstmann syndrome 10.3 MAPT APOE
21 hodgkin's lymphoma, lymphocytic depletion 10.3 CD79A C3
22 simultanagnosia 10.3 MAPT APOE
23 orthostatic proteinuria 10.3 REN ALB
24 polycystic kidney disease 4 10.3 REN ALB
25 familial hyperlipidemia 10.2 C3 APOE ADIPOQ
26 cryofibrinogenemia 10.2 TREX1 CD79A
27 progressive non-fluent aphasia 10.2 TMEM106B MAPT
28 visual agnosia 10.2 MAPT APOE
29 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.2
30 focal segmental glomerulosclerosis 10.2
31 glomerulonephritis 10.2
32 pyoderma 10.2
33 calciphylaxis 10.2
34 pyoderma gangrenosum 10.2
35 associative agnosia 10.2 TARDBP MAPT
36 alexia 10.2 MAPT APOE
37 degeneration of macula and posterior pole 10.2 SERPINA3 HTRA1 C3 APOE
38 kidney papillary necrosis 10.2 REN ALB
39 aspiration pneumonitis 10.2 SERPINA3 ALB
40 hypersensitivity vasculitis 10.2 SERPINA3 C3 ALB
41 hypersensitivity reaction type iii disease 10.2 SERPINA3 C3 ALB
42 hypertensive encephalopathy 10.2 REN ALB
43 severe nonproliferative diabetic retinopathy 10.2 REN ALB
44 ideomotor apraxia 10.2 TARDBP MAPT
45 prediabetes syndrome 10.2 SERPINA3 ALB ADIPOQ
46 severe pre-eclampsia 10.2 C3 ALB ADIPOQ
47 col4a1-related familial vascular leukoencephalopathy 10.1 TREX1 KCNJ13 HTRA1
48 chronic graft versus host disease 10.1 CD79A ALB
49 hypertensive retinopathy 10.1 REN ALB ADIPOQ
50 agraphia 10.1 TARDBP MAPT

Graphical network of the top 20 diseases related to Arteriolosclerosis:



Diseases related to Arteriolosclerosis

Symptoms & Phenotypes for Arteriolosclerosis

MGI Mouse Phenotypes related to Arteriolosclerosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 ABCC9 ADIPOQ ALB APOE APP C3
2 homeostasis/metabolism MP:0005376 9.97 ABCC9 ADIPOQ ALB APOE APP C3
3 muscle MP:0005369 9.65 ABCC9 ADIPOQ ALB APOE APP C3
4 renal/urinary system MP:0005367 9.23 ADIPOQ ALB APOE C3 CD79A MAPT

Drugs & Therapeutics for Arteriolosclerosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pathophysiology of Martorell Hypertensive Ischemic Leg Ulcer (HYTILU): A Comparison of Martorell HYTILU, Calciphylaxis and Venous Ulcer (Control) Unknown status NCT01578382
2 Effects of Standardized Aerobic Exercise-Training on Neurocognitive and Neurodegeneration Completed NCT01021644

Search NIH Clinical Center for Arteriolosclerosis

Cochrane evidence based reviews: arteriolosclerosis

Genetic Tests for Arteriolosclerosis

Anatomical Context for Arteriolosclerosis

MalaCards organs/tissues related to Arteriolosclerosis:

40
Kidney, Brain, Heart, Endothelial, Testes, Eye, Bone

Publications for Arteriolosclerosis

Articles related to Arteriolosclerosis:

(show top 50) (show all 436)
# Title Authors PMID Year
1
Association between serum adiponectin levels and arteriolosclerosis in IgA nephropathy patients. 54 61
17443034 2007
2
[Three-dimensional morphologic examination of normal and diseased renal arterioles]. 54 61
14686064 2003
3
Small vessel disease pathological changes in neurodegenerative and vascular dementias concomitant with autonomic dysfunction. 61
31357238 2020
4
Premature vascular disease in young adult stroke: a pathology-based case series. 61
31853711 2019
5
Pathogenetic pathways of cognitive dysfunction and dementia in metabolic syndrome. 61
31606384 2019
6
Common age-related neuropathologies and yearly variability in cognition. 61
31568713 2019
7
Limbic Predominant Age-Related TDP-43 Encephalopathy (LATE): Clinical and Neuropathological Associations. 61
31845964 2019
8
Intrarenal resistive index conundrum: systemic atherosclerosis versus renal arteriolosclerosis. 61
31599199 2019
9
A Novel Association of Martorell Ulcer With Liddle Syndrome. 61
31625969 2019
10
Neuropathological lesions in the very old: results from a large Brazilian autopsy study. 61
30861605 2019
11
Neuropathologic Correlates of White Matter Hyperintensities in a Community-Based Cohort of Older Adults. 61
31771057 2019
12
Peripheral arterial stiffness is correlated with intrarenal arteriolosclerosis according to biopsies from patients with kidney disease. 61
31576636 2019
13
Genome-wide association study of cerebral small vessel disease reveals established and novel loci. 61
31430377 2019
14
[Development of arteriosclerosis]. 61
31435781 2019
15
Hyaline Arteriolosclerosis in 30 Strains of Aged Inbred Mice. 61
31060453 2019
16
Neuropsychological latent classes at enrollment and postmortem neuropathology. 61
31420203 2019
17
Association of White Matter Rarefaction, Arteriolosclerosis, and Tau With Dementia in Chronic Traumatic Encephalopathy. 61
31380975 2019
18
Localization, Morphologic Features, and Chemical Composition of Calciphylaxis-Related Skin Deposits in Patients With Calcific Uremic Arteriolopathy. 61
31116362 2019
19
Relationship between androgenic alopecia and white matter hyperintensities in apparently healthy subjects. 61
31250269 2019
20
Extravascular fibrinogen in the white matter of Alzheimer's disease and normal aged brains: implications for fibrinogen as a biomarker for Alzheimer's disease. 61
30485582 2019
21
Pathologic glomerular characteristics and glomerular basement membrane alterations in biopsy-proven thin basement membrane nephropathy. 61
30687875 2019
22
Prediction of Acute Glomerular Filtration Rate Reductions Following Renin-angiotensin System Blockade in Chronic Kidney Disease: A Possible Application of Ultrasonography in Clinical Practice. 61
30626816 2019
23
Renal Damages in Deoxycorticosterone Acetate-Salt Hypertensive Rats: Assessment with Diffusion Tensor Imaging and T2-mapping. 61
31065896 2019
24
Cerebral small vessel disease in patients with spontaneous cerebellar hemorrhage. 61
30617995 2019
25
Stroke, cerebrovascular diseases and vascular cognitive impairment in Africa. 61
29807146 2019
26
Marmoset as a Model to Study Kidney Changes Associated With Aging. 61
30321310 2019
27
APOE genotypes as a risk factor for age-dependent accumulation of cerebrovascular disease in older adults. 61
30321502 2019
28
White matter capillaries in vascular and neurodegenerative dementias. 61
30732655 2019
29
Risk Profile of Ischemic Stroke Caused by Small-Artery Occlusion vs. Deep Intracerebral Hemorrhage. 61
31827458 2019
30
Neurovascular Ageing and Age-Related Diseases. 61
30888663 2019
31
Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies. 61
30421454 2019
32
Renovascular Hypertension Aggravates Atherosclerosis in Cholesterol-Fed Rabbits. 61
30947215 2019
33
Antiphospholipid Antibodies: Cognitive and Motor Decline, Neuroimaging and Neuropathology. 61
31067547 2019
34
Dichotomous scoring of TDP-43 proteinopathy from specific brain regions in 27 academic research centers: associations with Alzheimer's disease and cerebrovascular disease pathologies. 61
30567576 2018
35
Sex differences in Alzheimer's disease and common neuropathologies of aging. 61
30334074 2018
36
Severe white matter astrocytopathy in CADASIL. 61
29757481 2018
37
BMI, nephroangiosclerosis and glomerulonephritis: Is there any meeting point? 61
28817218 2018
38
Normoalbuminuric chronic kidney disease in diabetes. 61
30701803 2018
39
Postmortem brain MRI is related to cognitive decline, independent of cerebral vessel disease in older adults. 61
29908416 2018
40
Infratentorial Cerebral Microbleeds in Patients with Cerebral Amyloid Angiopathy. 61
29861129 2018
41
The Revised National Alzheimer's Coordinating Center's Neuropathology Form-Available Data and New Analyses. 61
29945202 2018
42
Association Between the Serum Uric Acid Levels and Lacunar Infarcts in the Elderly. 61
29974380 2018
43
Pericyte-derived bone morphogenetic protein 4 underlies white matter damage after chronic hypoperfusion. 61
28470822 2018
44
Brain pathology is related to total daily physical activity in older adults. 61
29695600 2018
45
The pathology and pathophysiology of vascular dementia. 61
29273521 2018
46
Review: Vascular dementia: clinicopathologic and genetic considerations. 61
29380913 2018
47
A case of chronic ulcer due to subcutaneous arteriolosclerosis in an obese patient mimicking pyoderma gangrenosum. 61
29887980 2018
48
The Edinburgh CT and genetic diagnostic criteria for lobar intracerebral haemorrhage associated with cerebral amyloid angiopathy: model development and diagnostic test accuracy study. 61
29331631 2018
49
White matter degeneration in vascular and other ageing-related dementias. 61
29210074 2018
50
Asymptomatic Cerebrovascular Disease in Dialysis Patients. 61
30041200 2018

Variations for Arteriolosclerosis

Expression for Arteriolosclerosis

Search GEO for disease gene expression data for Arteriolosclerosis.

Pathways for Arteriolosclerosis

Pathways related to Arteriolosclerosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.45 MAPT APP APOE

GO Terms for Arteriolosclerosis

Cellular components related to Arteriolosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.92 SERPINA3 REN HTRA1 C3 APP APOE
2 extracellular region GO:0005576 9.91 SERPINA3 REN MAPT HTRA1 C3 APP
3 endoplasmic reticulum lumen GO:0005788 9.67 C3 APP APOE ALB
4 platelet alpha granule lumen GO:0031093 9.33 SERPINA3 APP ALB
5 main axon GO:0044304 8.96 MAPT APP
6 blood microparticle GO:0072562 8.92 SERPINA3 C3 APOE ALB

Biological processes related to Arteriolosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.67 TARDBP MAPT APP APOE
2 astrocyte activation GO:0048143 9.46 MAPT APP
3 high-density lipoprotein particle remodeling GO:0034375 9.43 APOE ALB
4 positive regulation of cholesterol efflux GO:0010875 9.4 APOE ADIPOQ
5 negative regulation of long-term synaptic potentiation GO:1900272 9.32 APP APOE
6 amyloid fibril formation GO:1990000 9.26 MAPT APP
7 cellular protein metabolic process GO:0044267 9.26 C3 APP APOE ALB
8 neuron remodeling GO:0016322 9.16 C3 APP
9 positive regulation of amyloid fibril formation GO:1905908 8.62 APP APOE

Molecular functions related to Arteriolosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 TARDBP MAPT HTRA1 APP APOE ALB
2 lipoprotein particle binding GO:0071813 9.16 MAPT APOE
3 signaling receptor binding GO:0005102 9.02 REN C3 APP APOE ADIPOQ

Sources for Arteriolosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....