MCID: ART010
MIFTS: 37

Arteriolosclerosis

Categories: Cardiovascular diseases

Aliases & Classifications for Arteriolosclerosis

MalaCards integrated aliases for Arteriolosclerosis:

Name: Arteriolosclerosis 12 54 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5162
MeSH 43 D050379
NCIt 49 C35543
SNOMED-CT 67 17941002
ICD10 32 I70
UMLS 71 C0878486

Summaries for Arteriolosclerosis

MalaCards based summary : Arteriolosclerosis is related to glomerular disease and carotid stenosis. An important gene associated with Arteriolosclerosis is C3 (Complement C3), and among its related pathways/superpathways are Neuroscience and Alzheimers Disease. Affiliated tissues include kidney, brain and heart, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 74 Arteriolosclerosis is a form of cardiovascular disease involving hardening and loss of elasticity of... more...

Related Diseases for Arteriolosclerosis

Diseases related to Arteriolosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 196)
# Related Disease Score Top Affiliating Genes
1 glomerular disease 30.5 CD79A ALB
2 carotid stenosis 30.4 REN APOE ADIPOQ
3 iga glomerulonephritis 30.2 REN CD79A C3 ALB
4 chronic kidney disease 30.1 SERPINA3 REN APOE ALB ADIPOQ
5 end stage renal disease 29.9 REN C3 ALB ADIPOQ
6 kidney disease 29.6 SERPINA3 REN CD79A C3 APOE ALB
7 vascular dementia 29.3 SERPINA3 NOTCH3 MAPT APP APOE
8 cerebral amyloid angiopathy, cst3-related 29.1 TARDBP SNCA SERPINA3 PHF1 MAPT APP
9 cerebrovascular disease 27.8 TREX1 SERPINA3 REN NOTCH3 MAPT HTRA1
10 dementia 27.7 TMEM106B TARDBP SNCA SERPINA3 NOTCH3 MAPT
11 arteriosclerosis 10.5
12 tick-borne relapsing fever 10.4 HTRA1 C3
13 posterior cortical atrophy 10.4 MAPT APOE
14 hyperlipidemia, familial combined, 3 10.4 C3 APOE ADIPOQ
15 gastrointestinal lymphoma 10.4 SERPINA3 CD79A
16 residual stage of open angle glaucoma 10.3 APP APOE
17 senile plaque formation 10.3 APP APOE
18 gerstmann syndrome 10.3 MAPT APOE
19 simultanagnosia 10.3 MAPT APOE
20 progressive non-fluent aphasia 10.3 TMEM106B MAPT
21 primary lateral sclerosis, adult, 1 10.3 SNCA MAPT
22 pediatric systemic lupus erythematosus 10.3 C3 ADIPOQ
23 atherosclerosis susceptibility 10.3
24 visual agnosia 10.3 MAPT APOE
25 familial lcat deficiency 10.3 APOE ALB
26 associative agnosia 10.3 TARDBP MAPT
27 alzheimer disease 10 10.3 MAPT APOE
28 epidermolysis bullosa dystrophica, autosomal dominant 10.3 C3 ALB
29 alzheimer's disease 1 10.3 APP APOE
30 age-related hearing loss 10.2 MAPT APOE
31 ideomotor apraxia 10.2 TARDBP MAPT
32 alexia 10.2 MAPT APOE
33 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.2
34 focal segmental glomerulosclerosis 10.2
35 glomerulonephritis 10.2
36 pyoderma 10.2
37 calciphylaxis 10.2
38 pyoderma gangrenosum 10.2
39 orthostatic proteinuria 10.2 REN ALB
40 degeneration of macula and posterior pole 10.2 SERPINA3 HTRA1 C3 APOE
41 alzheimer disease 18 10.2 SNCA APP
42 olivopontocerebellar atrophy 10.2 SNCA SERPINA3 MAPT
43 chronic graft versus host disease 10.2 CD79A ALB
44 agraphia 10.2 TARDBP MAPT
45 nominal aphasia 10.2 TARDBP MAPT APOE
46 hypersensitivity vasculitis 10.2 SERPINA3 C3 ALB
47 autoimmune disease of blood 10.2 SERPINA3 C3 ALB
48 familial hyperlipidemia 10.2 C3 APOE ADIPOQ
49 machado-joseph disease 10.1 TARDBP SNCA APOE
50 multiple system atrophy 1 10.1 SNCA SERPINA3 MAPT

Graphical network of the top 20 diseases related to Arteriolosclerosis:



Diseases related to Arteriolosclerosis

Symptoms & Phenotypes for Arteriolosclerosis

MGI Mouse Phenotypes related to Arteriolosclerosis:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 ABCC9 ADIPOQ ALB APOE APP C3
2 cardiovascular system MP:0005385 10.26 ABCC9 ADIPOQ ALB APOE APP C3
3 behavior/neurological MP:0005386 10.24 ABCC9 ADIPOQ APOE APP C3 MAPT
4 growth/size/body region MP:0005378 10.21 ABCC9 ADIPOQ APOE APP C3 HTRA1
5 cellular MP:0005384 10.2 ABCC9 ADIPOQ ALB APOE APP C3
6 immune system MP:0005387 10.15 ADIPOQ ALB APOE APP C3 CD79A
7 mortality/aging MP:0010768 10.13 ABCC9 ADIPOQ ALB APOE APP C3
8 muscle MP:0005369 10 ABCC9 ADIPOQ ALB APOE APP C3
9 nervous system MP:0003631 9.9 ABCC9 ADIPOQ APOE APP C3 CD79A
10 normal MP:0002873 9.56 ALB APP C3 CD79A MAPT NOTCH3
11 renal/urinary system MP:0005367 9.32 ADIPOQ ALB APOE C3 CD79A MAPT

Drugs & Therapeutics for Arteriolosclerosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pathophysiology of Martorell Hypertensive Ischemic Leg Ulcer (HYTILU): A Comparison of Martorell HYTILU, Calciphylaxis and Venous Ulcer (Control) Unknown status NCT01578382
2 Effects of Standardized Aerobic Exercise-Training on Neurocognitive and Neurodegeneration Completed NCT01021644

Search NIH Clinical Center for Arteriolosclerosis

Cochrane evidence based reviews: arteriolosclerosis

Genetic Tests for Arteriolosclerosis

Anatomical Context for Arteriolosclerosis

MalaCards organs/tissues related to Arteriolosclerosis:

40
Kidney, Brain, Heart, Endothelial, Testes, Eye, Bone

Publications for Arteriolosclerosis

Articles related to Arteriolosclerosis:

(show top 50) (show all 440)
# Title Authors PMID Year
1
Association between serum adiponectin levels and arteriolosclerosis in IgA nephropathy patients. 54 61
17443034 2007
2
[Three-dimensional morphologic examination of normal and diseased renal arterioles]. 54 61
14686064 2003
3
Peripheral arterial stiffness is correlated with intrarenal arteriolosclerosis according to biopsies from patients with kidney disease. 61
31576636 2020
4
Premature vascular disease in young adult stroke: a pathology-based case series. 61
31853711 2020
5
Relationship between androgenic alopecia and white matter hyperintensities in apparently healthy subjects. 61
31250269 2020
6
Limbic Predominant Age-Related TDP-43 Encephalopathy (LATE): Clinical and Neuropathological Associations. 61
31845964 2020
7
Podocyte-targeted Heme Oxygenase (HO)-1 overexpression exacerbates age-related pathology in the rat kidney. 61
32235880 2020
8
Renal Damages in Deoxycorticosterone Acetate-Salt Hypertensive Rats: Assessment with Diffusion Tensor Imaging and T2-mapping. 61
31065896 2020
9
Small vessel disease pathological changes in neurodegenerative and vascular dementias concomitant with autonomic dysfunction. 61
31357238 2020
10
Neuropathologic Correlates of White Matter Hyperintensities in a Community-Based Cohort of Older Adults. 61
31771057 2020
11
Clinical Features and Experimental Models of Cerebral Small Vessel Disease. 61
32431603 2020
12
Preoperative Comorbidities and Outcomes of Medically Complex Living Kidney Donors. 61
31922057 2020
13
Pathogenetic pathways of cognitive dysfunction and dementia in metabolic syndrome. 61
31606384 2019
14
Common age-related neuropathologies and yearly variability in cognition. 61
31568713 2019
15
Intrarenal resistive index conundrum: systemic atherosclerosis versus renal arteriolosclerosis. 61
31599199 2019
16
A Novel Association of Martorell Ulcer With Liddle Syndrome. 61
31625969 2019
17
Neuropathological lesions in the very old: results from a large Brazilian autopsy study. 61
30861605 2019
18
Genome-wide association study of cerebral small vessel disease reveals established and novel loci. 61
31430377 2019
19
[Development of arteriosclerosis]. 61
31435781 2019
20
Hyaline Arteriolosclerosis in 30 Strains of Aged Inbred Mice. 61
31060453 2019
21
Neuropsychological latent classes at enrollment and postmortem neuropathology. 61
31420203 2019
22
Association of White Matter Rarefaction, Arteriolosclerosis, and Tau With Dementia in Chronic Traumatic Encephalopathy. 61
31380975 2019
23
Localization, Morphologic Features, and Chemical Composition of Calciphylaxis-Related Skin Deposits in Patients With Calcific Uremic Arteriolopathy. 61
31116362 2019
24
Prediction of Acute Glomerular Filtration Rate Reductions Following Renin-angiotensin System Blockade in Chronic Kidney Disease: A Possible Application of Ultrasonography in Clinical Practice. 61
30626816 2019
25
Extravascular fibrinogen in the white matter of Alzheimer's disease and normal aged brains: implications for fibrinogen as a biomarker for Alzheimer's disease. 61
30485582 2019
26
Pathologic glomerular characteristics and glomerular basement membrane alterations in biopsy-proven thin basement membrane nephropathy. 61
30687875 2019
27
Cerebral small vessel disease in patients with spontaneous cerebellar hemorrhage. 61
30617995 2019
28
Stroke, cerebrovascular diseases and vascular cognitive impairment in Africa. 61
29807146 2019
29
Marmoset as a Model to Study Kidney Changes Associated With Aging. 61
30321310 2019
30
APOE genotypes as a risk factor for age-dependent accumulation of cerebrovascular disease in older adults. 61
30321502 2019
31
White matter capillaries in vascular and neurodegenerative dementias. 61
30732655 2019
32
Risk Profile of Ischemic Stroke Caused by Small-Artery Occlusion vs. Deep Intracerebral Hemorrhage. 61
31827458 2019
33
Yiqihuoxue Formula Activates Autophagy and Offers Renoprotection in a Rat Model of Adenine-Induced Kidney Disease. 61
31949466 2019
34
Neurovascular Ageing and Age-Related Diseases. 61
30888663 2019
35
Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies. 61
30421454 2019
36
Renovascular Hypertension Aggravates Atherosclerosis in Cholesterol-Fed Rabbits. 61
30947215 2019
37
Antiphospholipid Antibodies: Cognitive and Motor Decline, Neuroimaging and Neuropathology. 61
31067547 2019
38
Dichotomous scoring of TDP-43 proteinopathy from specific brain regions in 27 academic research centers: associations with Alzheimer's disease and cerebrovascular disease pathologies. 61
30567576 2018
39
Sex differences in Alzheimer's disease and common neuropathologies of aging. 61
30334074 2018
40
Severe white matter astrocytopathy in CADASIL. 61
29757481 2018
41
BMI, nephroangiosclerosis and glomerulonephritis: Is there any meeting point? 61
28817218 2018
42
Normoalbuminuric chronic kidney disease in diabetes. 61
30701803 2018
43
Infratentorial Cerebral Microbleeds in Patients with Cerebral Amyloid Angiopathy. 61
29861129 2018
44
Postmortem brain MRI is related to cognitive decline, independent of cerebral vessel disease in older adults. 61
29908416 2018
45
The Revised National Alzheimer's Coordinating Center's Neuropathology Form-Available Data and New Analyses. 61
29945202 2018
46
Association Between the Serum Uric Acid Levels and Lacunar Infarcts in the Elderly. 61
29974380 2018
47
Pericyte-derived bone morphogenetic protein 4 underlies white matter damage after chronic hypoperfusion. 61
28470822 2018
48
The pathology and pathophysiology of vascular dementia. 61
29273521 2018
49
Brain pathology is related to total daily physical activity in older adults. 61
29695600 2018
50
Review: Vascular dementia: clinicopathologic and genetic considerations. 61
29380913 2018

Variations for Arteriolosclerosis

Expression for Arteriolosclerosis

Search GEO for disease gene expression data for Arteriolosclerosis.

Pathways for Arteriolosclerosis

Pathways related to Arteriolosclerosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.63 TARDBP SNCA NOTCH3 MAPT APP APOE
2 11.43 SNCA MAPT APP APOE
3 10.99 MAPT APP APOE

GO Terms for Arteriolosclerosis

Cellular components related to Arteriolosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.67 C3 APP APOE ALB
2 extracellular space GO:0005615 9.61 SNCA SERPINA3 REN HTRA1 C3 APP
3 platelet alpha granule lumen GO:0031093 9.5 SERPINA3 APP ALB
4 blood microparticle GO:0072562 9.46 SERPINA3 C3 APOE ALB
5 extracellular region GO:0005576 9.36 SNCA SERPINA3 REN NOTCH3 MAPT HTRA1
6 main axon GO:0044304 9.26 MAPT APP

Biological processes related to Arteriolosclerosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.81 TARDBP MAPT APP APOE
2 astrocyte activation GO:0048143 9.54 MAPT APP
3 high-density lipoprotein particle remodeling GO:0034375 9.52 APOE ALB
4 synapse organization GO:0050808 9.5 SNCA MAPT APP
5 negative regulation of long-term synaptic potentiation GO:1900272 9.49 APP APOE
6 supramolecular fiber organization GO:0097435 9.48 SNCA MAPT
7 cellular response to epinephrine stimulus GO:0071872 9.46 SNCA ADIPOQ
8 amyloid fibril formation GO:1990000 9.43 MAPT APP
9 neuron remodeling GO:0016322 9.4 C3 APP
10 negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642 9.37 SNCA ADIPOQ
11 gene expression GO:0010467 9.33 TARDBP APOE ADIPOQ
12 positive regulation of amyloid fibril formation GO:1905908 9.26 APP APOE
13 microglial cell activation GO:0001774 9.13 SNCA MAPT APP
14 cellular protein metabolic process GO:0044267 9.02 SNCA C3 APP APOE ALB

Molecular functions related to Arteriolosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.36 TREX1 TARDBP SNCA NOTCH3 MAPT HTRA1
2 signaling receptor binding GO:0005102 9.35 REN C3 APP APOE ADIPOQ
3 lipoprotein particle binding GO:0071813 9.16 MAPT APOE

Sources for Arteriolosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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