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MCID: ART021
MIFTS: 61

Arteriosclerosis

Categories: Cardiovascular diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Arteriosclerosis

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MalaCards integrated aliases for Arteriosclerosis:

Name: Arteriosclerosis 12 56 6 45 15 17 74
Arteriosclerotic Vascular Disease 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:2349
MeSH 45 D001161
NCIt 51 C34398
SNOMED-CT 69 28960008 72092001
ICD10 34 I70
UMLS 74 C0003850
Sources

Summaries for Arteriosclerosis

About this section
Disease Ontology : 12 An artery disease that is characterized by a thickening and hardening of arterial walls in the arteries.

MalaCards based summary : Arteriosclerosis, also known as arteriosclerotic vascular disease, is related to arteriosclerosis obliterans and ischemic heart disease, and has symptoms including angina pectoris An important gene associated with Arteriosclerosis is HS3ST1 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins. The drugs Aspirin and Cilostazol have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and testes, and related phenotypes are shRNA abundance <= 50% and Decreased free cholesterol

Wikipedia : 77 Arteriosclerosis is the thickening, hardening, and loss of elasticity of the walls of arteries. This... more...

Sources

Related Diseases for Arteriosclerosis

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Diseases in the Arteriosclerosis family:

Arteriosclerosis, Severe Juvenile

Diseases related to Arteriosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 253)
# Related Disease Score Top Affiliating Genes
1 arteriosclerosis obliterans 34.5 ADIPOQ ICAM1 VCAM1
2 ischemic heart disease 32.9 APOA1 APOB APOE
3 coronary artery anomaly 32.3 APOA1 APOB COG2 EDN1 HMGCR PON1
4 cerebral atherosclerosis 32.0 APOA1 APOE
5 coronary heart disease 1 31.9 ADIPOQ APOA1 APOB APOE COG2 HMGCR
6 hyperlipoproteinemia, type iii 31.7 APOA1 APOB APOE COG2 HMGCR
7 atherosclerosis susceptibility 31.2 ADIPOQ APOA1 APOB APOE CCL2 ICAM1
8 ischemia 30.9 EDN1 HMOX1 ICAM1 PON1
9 peripheral vascular disease 30.5 APOA1 APOB SERPINE1 VCAM1
10 aortic aneurysm, familial abdominal, 1 30.5 APOE CCL2 ELN
11 heart disease 30.4 APOA1 APOB APOE EDN1 ELN ICAM1
12 vasculitis 30.4 CCL2 ICAM1 VCAM1
13 hypertriglyceridemia, familial 30.3 APOA1 APOB APOE
14 stroke, ischemic 30.3 APOB APOE COG2 HMGCR PON1 SERPINE1
15 hypertension, essential 30.2 ADIPOQ APOA1 APOB EDN1 SERPINE1
16 chronic venous insufficiency 30.2 ICAM1 SERPINE1 VCAM1
17 venous insufficiency 30.2 ICAM1 SERPINE1 VCAM1
18 diabetes mellitus 30.2 ADIPOQ APOA1 APOB COG2 EDN1 HMGCR
19 pseudoxanthoma elasticum 30.1 ELN MGP SPP1
20 chronic kidney failure 30.1 ADIPOQ APOB EDN1 HMGCR ICAM1 PON1
21 acute myocardial infarction 30.1 APOA1 APOB EDN1 SERPINE1
22 pulmonary edema 30.0 EDN1 HMOX1 ICAM1
23 myocardial infarction 30.0 ADIPOQ APOA1 APOB APOE CCL2 COG2
24 sleep apnea 30.0 ADIPOQ APOE EDN1 ICAM1
25 kidney disease 30.0 ADIPOQ APOE CCL2 EDN1 HMGCR HMOX1
26 arcus corneae 30.0 APOA1 APOB APOE COG2
27 coronary stenosis 29.8 APOA1 APOB APOE ICAM1 PON1 SERPINE1
28 lipid metabolism disorder 29.7 ADIPOQ APOA1 APOB APOE COG2 HMGCR
29 hypercholesterolemia, familial 29.7 APOA1 APOB APOE COG2 HMGCR PON1
30 arteries, anomalies of 29.6 ADIPOQ APOA1 APOB APOE CCL2 COG2
31 diabetes mellitus, noninsulin-dependent 29.1 ADIPOQ APOA1 APOB APOE CCL2 COG2
32 vascular disease 29.0 ADIPOQ APOA1 APOB APOE CCL2 EDN1
33 cerebral arteriosclerosis 12.6
34 monckeberg arteriosclerosis 12.4
35 intracranial arteriosclerosis 12.1
36 arteriosclerosis, severe juvenile 12.0
37 spinal cord infarction 11.2
38 arterial calcification of infancy 11.2
39 schimke immunoosseous dysplasia 11.1
40 werner syndrome 11.1
41 hypertension, diastolic 11.1
42 retinopathy, arteriosclerotic 11.0
43 malignant hypertensive renal disease 10.5 EDN1 SERPINE1
44 malignant renovascular hypertension 10.5 EDN1 SERPINE1
45 coronary artery aneurysm 10.5 ADIPOQ CCL2 VCAM1
46 subendocardial myocardial infarction 10.5 ICAM1 SERPINE1 VCAM1
47 post-thrombotic syndrome 10.5 CCL2 ICAM1 SERPINE1
48 abdominal obesity-metabolic syndrome 1 10.4 ADIPOQ PPARG SERPINE1
49 herpes simplex virus keratitis 10.4 CCL2 ICAM1
50 dysbaric osteonecrosis 10.4 ADIPOQ APOA1 APOB SERPINE1

Graphical network of the top 20 diseases related to Arteriosclerosis:



Diseases related to Arteriosclerosis
Sources

Symptoms & Phenotypes for Arteriosclerosis

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UMLS symptoms related to Arteriosclerosis:


angina pectoris

GenomeRNAi Phenotypes related to Arteriosclerosis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.32 APOA1 APOB DAB2IP HMOX1 HS3ST1 HSPD1
2 Decreased free cholesterol GR00340-A-2 9.26 APOA1 APOB APOE HMGCR

MGI Mouse Phenotypes related to Arteriosclerosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.25 ADIPOQ APOA1 APOB APOE EDN1 HMOX1
2 homeostasis/metabolism MP:0005376 10.25 ADIPOQ APOA1 APOB APOE COG2 DAB2IP
3 growth/size/body region MP:0005378 10.24 ADIPOQ APOB APOE COG2 EDN1 HMGCR
4 cellular MP:0005384 10.18 ADIPOQ APOA1 APOB APOE DAB2IP HMOX1
5 mortality/aging MP:0010768 10 ADIPOQ APOB APOE EDN1 HMGCR HMOX1
6 liver/biliary system MP:0005370 9.91 ADIPOQ APOA1 APOB APOE HMGCR HMOX1
7 muscle MP:0005369 9.65 ADIPOQ APOB APOE EDN1 HMOX1 HSPD1
8 renal/urinary system MP:0005367 9.23 ADIPOQ APOE EDN1 HMOX1 MGP PPARG
Sources

Drugs & Therapeutics for Arteriosclerosis

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Drugs for Arteriosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 937)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-78-2 2244
2
Cilostazol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 73963-72-1 2754
3
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 57-83-0 5994
4
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-28-2 5757
5
Polyestradiol phosphate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 28014-46-2
6
Nicotinamide Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 98-92-0 936
7
Atorvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 134523-00-5 60823
8
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 159351-69-6 6442177 70789204
9
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53123-88-9 46835353 6436030 5284616
10
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
11
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 120202-66-6, 113665-84-2 60606
12
Methyltestosterone Approved Phase 4,Phase 3,Phase 2,Not Applicable 58-18-4 6010
13
Testosterone undecanoate Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 5949-44-0
14
Testosterone Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 58-22-0, 481-30-1 6013 10204
15
Testosterone enanthate Approved Phase 4,Phase 3,Phase 2,Not Applicable 315-37-7 9416
16
Pravastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 81093-37-0 54687
17
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
18
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1401-55-4
19
Enalapril Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 75847-73-3 5362032 40466924
20
Rimonabant Approved, Investigational Phase 4,Phase 3,Not Applicable 168273-06-1, 158681-13-1 104850
21
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 79902-63-9 54454
22
Enalaprilat Approved Phase 4,Phase 3,Phase 2,Not Applicable 76420-72-9 6917719
23
leucovorin Approved Phase 4,Phase 2,Phase 3,Not Applicable 58-05-9 6006 143
24
Hydroxocobalamin Approved Phase 4,Phase 2,Phase 3,Not Applicable 13422-51-0 11953898 15589840
25
Phylloquinone Approved, Investigational Phase 4,Phase 2,Not Applicable 84-80-0
26
Paclitaxel Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 33069-62-4 36314
27
Bivalirudin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 128270-60-0 16129704
28
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6 772 46507594
29
Etomidate Approved Phase 4 33125-97-2 36339 667484
30
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 113775-47-6 68602 5311068
31
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 28523-86-6 5206
32
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 71273 175805
33
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
34
Sufentanil Approved, Investigational Phase 4,Not Applicable 56030-54-7 41693
35
Ticagrelor Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 274693-27-5 9871419
36
Trimetazidine Approved, Investigational Phase 4,Not Applicable 5011-34-7
37
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 10102-43-9 145068
38
Isosorbide Dinitrate Approved, Investigational Phase 4,Phase 3,Not Applicable 87-33-2 6883
39
AT-101 Approved, Investigational Phase 4,Phase 3,Not Applicable 90141-22-3, 652-67-5 12597
40
Metoprolol Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 37350-58-6, 51384-51-1 4171
41
Chitosan Approved Phase 4 9012-76-4 71853
42
Thrombin Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable
43
Vorapaxar Approved Phase 4,Phase 3,Phase 2 618385-01-6
44
Ezetimibe Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 163222-33-1 150311
45
Tirofiban Approved Phase 4,Phase 3,Phase 1 144494-65-5 60947
46
Pantoprazole Approved Phase 4,Phase 3 102625-70-7 4679
47
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3 73590-58-6 4594
48
Tocopherol Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 1406-66-2 14986
49
Lovastatin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 75330-75-5 53232
50
Chromium Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-47-3 27668

Interventional clinical trials:

(show top 50) (show all 6064)
# Name Status NCT ID Phase Drugs
1 Sufficient Treatment of Peripheral Intervention by Cilostazol Unknown status NCT00912756 Phase 4 cilostazol
2 Kronos Early Estrogen Prevention Study (KEEPS) Unknown status NCT00154180 Phase 4 Conjugated equine estrogens 0.45 mg/day;Transdermal estradiol, 50 mcg/day;Micronized progesterone, 200 mg/day x 12 d/month;CEE , progesterone, estradiol patch or placebo for each;CEE, progesterone, transdermal patch or the placebo
3 Study to Investigate the Effect of Heart Rate Reduction With Ivabradine on Vascular Elastic Properties and Endothelial Function in Patients With Stable Coronary Heart Disease Unknown status NCT01768585 Phase 4 Ivabradine;Placebo
4 The Low HDL On Six Weeks Statin Therapy (LOW) Study Unknown status NCT00238004 Phase 4 Nicotinic acid
5 Effect of Short Term Atorvastatin Treatment,80mg/Day on Early Regression of Carotid Artery Atherosclerotic Lesions Unknown status NCT00640744 Phase 4 Atorvastatin
6 Fibrosis in Renal Allografts Unknown status NCT00493194 Phase 4 sirolimus;cyclosporine;daclizumab
7 The Elderly ACS II Trial Unknown status NCT01777503 Phase 4 prasugrel;Clopidogrel
8 Testosterone Therapy on Angina Threshold and Atheroma in Patients With Chronic Stable Angina Unknown status NCT00131183 Phase 4 Nebido
9 Intensive Statin Treatment in Acute Ischemic Stroke Patients With INtracranial Atherosclerosis Unknown status NCT02458755 Phase 4 High-dose statin: Atorvastatin 40mg or Rosuvastatin 20mg
10 The Effects of Pravastatin and Rosuvastatin on Coronary Plaques in Patients With Stable Angina Pectoris Unknown status NCT01325818 Phase 4 pravastatin, rosuvastatin
11 Does Rosuvastatin Delay Progression of Atherosclerosis in HIV Unknown status NCT01813357 Phase 4 Rosuvastatin
12 Early Detection of Atherosclerosis: a Randomized Trial in the Primary Prevention of Cardiovascular Diseases. Unknown status NCT00734123 Phase 4 Simvastatin or Atorvastatin;Enalapril;Aspirin or clopidogrel;Rimonabant
13 Homocysteine Lowering and Atherosclerosis Reduction Trial (HART) Unknown status NCT00217178 Phase 4 Vitamins: Folic acid, B6, B12
14 Vitamin K2 and Vessel Calcification in Chronic Kidney Disease Patients Unknown status NCT01101698 Phase 4 Vitamin K2+10μg cholecalciferol;Vitamin D
15 Paclitaxel Eluting Stent or Exercise for Thigh Atherosclerosis Unknown status NCT02033135 Phase 4
16 Efficacy of Self-Expanding Nitinol S.M.A.R.T CONTROL Stent Versus Life Stent For The Atherosclerotic Femoro-Popliteal Arterial Disease Unknown status NCT01653600 Phase 4
17 The Effect of Vitamin A on Atherosclerosis Unknown status NCT01414972 Phase 4 Vitamin A;placebo
18 The Study of the Effects of Vitamin A on Immune System in Patients With Atherosclerosis Unknown status NCT00963222 Phase 4 vitamin A;placebo
19 The Effect of Dates on Plasma Lipids, Oxidative Stress and the Atherogenicity of Serum in Healthy Adults Unknown status NCT00750789 Phase 4
20 Fluvastatin AmelIorates aTHerosclerosis Study Unknown status NCT01681199 Phase 4 Fluvastatin extended release tablet
21 The ABC Trial Does All-Blood Cardioplegia Prevent Blood Transfusion in Cardiac Surgery? A Single Centre Pilot Study Unknown status NCT01623193 Phase 4
22 Different Dosage of Domestic and Imported Clopidogrel on the Platelet Inhibition Ratio in Patients Undergoing PCI Unknown status NCT03006835 Phase 4 Clopidogrel
23 Bivalirudin in Stable Ischemic Heart Disease Patients Undergoing PCI Unknown status NCT02787317 Phase 4 bivalirudin;Heparin
24 The Effect of a Natural Polyphenolic Extract From Pomegrnate (POMX) on the Development of Atherosclerosis in Diabetic Patients Unknown status NCT00470808 Phase 4 POMx
25 Studies of Application of Combined General Anesthesia and Bilateral TPVB in OPCABG Unknown status NCT02727712 Phase 4 Anesthesia drugs during the surgery
26 ATHERO: Advanced Technology Halting Early Re-Stenosis and Occlusion Unknown status NCT00407940 Phase 4
27 Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis- EXtended Antiplatelet Monotherapy (HOST-EXAM) Unknown status NCT02044250 Phase 4 Clopidogrel;Aspirin
28 Endothelial Dysfunction in Subjects With History of Premature Coronary Artery Disease Unknown status NCT00917527 Phase 4 Atorvastatin
29 Relation Among Shear Stress Distribution, Stent Design, and Subsequent Vessel Healing After Drug-eluting Stent Implantation (SHEAR DES) Unknown status NCT01942044 Phase 4
30 Danshen Dropping Pill for Coronary Heart Disease Heart and Artery Structure and Function Unknown status NCT01825759 Phase 4 danshen dripping pill
31 Intracoronary Stenting and Antithrombotic Regimen: ADjusting Antiplatelet Treatment in PatienTs Based on Platelet Function Testing Unknown status NCT01456364 Phase 4 Ticagrelor;Prasugrel
32 Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis - SAfety & EffectiveneSS of Drug-ElUting Stents & Anti-platelet REgimen Unknown status NCT01267734 Phase 4 Triple anti-platelet therapy (TAT);Double-dose clopidogrel anti-platelet therapy (DDAT)
33 Test of Long-Term Safety and Efficacy of Sirolimus-Permanent-Polymer Eluting Stent (Cypher)- and Sirolimus-Polymer-free Eluting Stents (PPS/PFS) Assessed by Optical Coherence Tomography Unknown status NCT01260558 Phase 4
34 Test Safety and Efficacy of Zotarolimus- and Everolimus-Eluting Stents (ZES/EES) Assessed by Optical Coherence Tomography Unknown status NCT01230723 Phase 4
35 Paclitaxel Eluting Balloon and Conventional Balloon for In-Stent Restenosis of the Superficial Femoral Artery Unknown status NCT01083394 Phase 4
36 Test Efficacy of Biodegradable and Permanent Limus-Eluting Stents Unknown status NCT01068106 Phase 4
37 Efficacy Study of Stenting, Paclitaxel Eluting Balloon or Atherectomy to Treat Peripheral Artery Disease Unknown status NCT00986752 Phase 4
38 The Effect of Ticagrelor on 15-Epi-Lipoxin A4 and Inflammation Unknown status NCT02626169 Phase 4 Clopidogrel;Ticagrelor
39 Intensive Rosuvastatin Therapy on Cerebral Hemodynamics in Patients With Atherosclerotic Intracranial Arterial Stenosis Unknown status NCT02594800 Phase 4 Rosuvastatin
40 A Multicenter, Therapeutic Used Study to Evaluate the Efficacy and Safety of Pletaal SR Capsule (Cilostazol) in Subjects With Peripheral Arterial Disease Symptom Due to Chronic Occlusive Arterial Disease Unknown status NCT01711333 Phase 4 Pletaal SR capsule
41 Curative Effect Evaluation of Shexiang Baoxin Pill on Coronary Artery Disease Not Amenable to Revascularization Unknown status NCT03072121 Phase 4 Shexiang Baoxin pill;SBP placebo;Aspirin Enteric-coated Tablets;Clopidogrel Hydrogen Sulfate 75 MG Oral Tablet;Atorvastatin Calcium;Isosorbide Mononitrate Tab 20 MG;Metoprolol Tartrate Tab 25 MG;Trimetazidine Dihydrochloride Tablets
42 Curative Effect Evaluation of Danlou Tablet on Coronary Artery Disease Not Amenable to Revascularization Unknown status NCT03072082 Phase 4 Danlou Tablet;DanLou Tablet placebo;Aspirin Enteric-coated Tablets;Clopidogrel Hydrogen Sulfate 75 MG Oral Tablet;Atorvastatin calcium;Isosorbide Mononitrate Tab 20 MG;Metoprolol Tartrate Tab 25 MG;Trimetazidine Dihydrochloride Tablets
43 Residual Platelet Activity In Advanced Peripheral Artery Disease Unknown status NCT01627431 Phase 4 Acetylsalicylic acid;Clopidogrel
44 Periodontal Therapy in Coronary Artery Patients Unknown status NCT01609725 Phase 4
45 Using 3D Imaging to Optimize Bifurcation Stenting Unknown status NCT02972489 Phase 4
46 Hemostasis Pad Using Chitosan After Invasive Percutaneous Procedures Unknown status NCT02954029 Phase 4
47 Prospective Multicenter Registry of Hybrid Coronary Artery Revascularization Combined With Surgical Bypass and Percutaneous Coronary Intervention Using Everolimus Eluting Metallic Stents Unknown status NCT02894255 Phase 4
48 Influence of Vorapaxar on Thrombin Generation and Coagulability Unknown status NCT02629367 Phase 4 Vorapaxar;Asprin;Clopidogrel
49 Optimizing Timing of CABG in Patients Presenting With ACS and Treated With Ticagrelor Unknown status NCT02627521 Phase 4 Ticagrelor
50 Ezetimibe and Atorvastatin Therapy on TCFA Unknown status NCT02588235 Phase 4 Ezetimibe and Atorvastatin;Atorvastatin

Search NIH Clinical Center for Arteriosclerosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: arteriosclerosis

Sources

Genetic Tests for Arteriosclerosis

About this section
Sources

Anatomical Context for Arteriosclerosis

About this section

MalaCards organs/tissues related to Arteriosclerosis:

42
Heart, Endothelial, Testes, Bone, Kidney, Bone Marrow, Brain
Sources

Publications for Arteriosclerosis

About this section

Articles related to Arteriosclerosis:

(show top 50) (show all 2404)
# Title Authors Year
1
The association between local arteriosclerosis of the prostatic arteries and chronic inflammation in human benign prostatic enlargement. ( 30637787 )
2019
2
Non-alcoholic steatohepatitis aggravates nitric oxide synthase inhibition-induced arteriosclerosis in SHRSP5/Dmcr rat model. ( 30680827 )
2019
3
Impact of diastolic blood pressure threshold for the young population: the Japan Arteriosclerosis Longitudinal Study (JALS). ( 30702497 )
2019
4
Bilateral cerebral infarction associated with severe arteriosclerosis in the A1 segment: a case report. ( 30760064 )
2019
5
Absolute risk score for stroke, myocardial infarction, and all cardiovascular disease: Japan Arteriosclerosis Longitudinal Study. ( 30760890 )
2019
6
The differentiation of mesenchymal stem cells to vascular cells regulated by the HMGB1/RAGE axis: its application in cell therapy for transplant arteriosclerosis. ( 29615103 )
2018
7
Pulsatile flow of non-Newtonian blood fluid inside stenosed arteries: Investigating the effects of viscoelastic and elastic walls, arteriosclerosis, and polycythemia diseases. ( 29249336 )
2018
8
Spontaneously occurring intramural coronary arteriosclerosis in regularly slaughtered veal calves and beef cattle: aA screening study about prevalence and histopathological features. ( 29371083 )
2018
9
Graft protective effect and induction of CD4<sup>+</sup>Foxp3<sup>+</sup> cell by Thrombomodulin on allograft arteriosclerosis in mice. ( 29783997 )
2018
10
Clipping treatment of posterior communicating artery aneurysms associated with arteriosclerosis and calcification: A single center study of 136 cases. ( 29434749 )
2018
11
MicroRNA-31 promotes arterial smooth muscle cell proliferation and migration by targeting mitofusin-2 in arteriosclerosis obliterans of the lower extremitie. ( 29403548 )
2018
12
Retinal vessel narrowing: an early predictor of future arteriosclerosis? ( 29384985 )
2018
13
Arteriosclerosis Is a Major Predictor of Small Bowel Vascular Lesions. ( 29372478 )
2018
14
Increased plasma olfactomedin 2 after interventional therapy is a predictor for restenosis in lower extremity arteriosclerosis obliterans patients. ( 29553861 )
2018
15
Pronounced Coronary Arteriosclerosis in Cirrhosis: Influence on Cardiac Function and Survival? ( 29516327 )
2018
16
Night-time activation of the intrarenal renin-angiotensin system due to nocturnal hypertension is associated with renal arteriosclerosis in normotensive IgA nephropathy patients. ( 29507351 )
2018
17
Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study. ( 29382349 )
2018
18
Accelerated atheromatosis and arteriosclerosis in primary systemic vasculitides: current evidence and future perspectives. ( 29040156 )
2018
19
Role of Resident Stem Cells in Vessel Formation and Arteriosclerosis. ( 29798903 )
2018
20
Response by Daugherty et al to Letter Regarding Article, &amp;quot;Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies: A Statement From the <i>Arteriosclerosis, Thrombosis, and Vascular Biology</i> Council&amp;quot;. ( 29793996 )
2018
21
Arteriosclerosis, Thrombosis, and Vascular Biology. ( 29282242 )
2018
22
Assessment of Subtle Changes in Diabetes-Associated Arteriosclerosis using Photoplethysmographic Pulse Wave from Index Finger. ( 29368039 )
2018
23
Arteriosclerosis in Brazil. Findings from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). ( 29791607 )
2018
24
Letter by Ramirez and Hibbert Regarding Article, &amp;quot;Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies: A Statement From the <i>Arteriosclerosis, Thrombosis, and Vascular Biology</i> Council&amp;quot;. ( 29793995 )
2018
25
Circulating odd-chain saturated fatty acids were associated with arteriosclerosis among patients with diabetes, dyslipidemia, or hypertension in Sri Lanka but not Japan. ( 29540275 )
2018
26
Consensus document of the Spanish Society of Arteriosclerosis (SEA) for the prevention and treatment of cardiovascular disease in type 2 diabetes mellitus. ( 30053980 )
2018
27
Outcomes in Patients with Critical Limb Ischemia due to Arteriosclerosis Obliterans Who Did Not Undergo Arterial Reconstruction. ( 30101855 )
2018
28
Relationship between ABCA1 gene polymorphism and lacunar infarction combined with arteriosclerosis in patients. ( 30112062 )
2018
29
Prevalence, Incidence, and Contributors of Subclinical Atheromatosis, Arteriosclerosis, and Arterial Hypertrophy in HIV-Infected Individuals: A Single-Center, 3-Year Prospective Study. ( 30235944 )
2018
30
PI3Kγ promotes vascular smooth muscle cell phenotypic modulation and transplant arteriosclerosis via a SOX9-dependent mechanism. ( 30241919 )
2018
31
FAL1 regulates endothelial cell proliferation in diabetic arteriosclerosis through PTEN/AKT pathway. ( 30338819 )
2018
32
Usefulness of Carotid Arterial Strain Values for Evaluating the Arteriosclerosis. ( 30344204 )
2018
33
Intravenous hydrogen sulfide does not induce neuroprotection after aortic balloon occlusion-induced spinal cord ischemia/reperfusion injury in a human-like porcine model of ubiquitous arteriosclerosis. ( 30357563 )
2018
34
HOXA11-AS regulates diabetic arteriosclerosis-related inflammation via PI3K/AKT pathway. ( 30402857 )
2018
35
Cardiac Allograft Vasculopathy　- Heart Transplantation Provides Insights Into Pathogenesis and Treatment of Arteriosclerosis. ( 30404978 )
2018
36
AIP1 suppresses transplant arteriosclerosis through inhibition of vascular smooth muscle cell inflammatory response to IFNγ. ( 30471213 )
2018
37
Association of renal arteriosclerosis and hypertension with renal and cardiovascular outcomes in Japanese type 2 diabetes patients with diabetic nephropathy. ( 30516352 )
2018
38
Subclinical parameters of arterial stiffness and arteriosclerosis correlate with QRISK3 in systemic lupus erythematosus. ( 30517121 )
2018
39
Association of arteriosclerosis and/or atherosclerosis with hypertensive target organ damage in the community-dwelling elderly Chinese: the Northern Shanghai Study. ( 28652715 )
2017
40
Efficacy of continuous positive airway pressure treatment in treating obstructive sleep apnea hypopnea syndrome associated with carotid arteriosclerosis. ( 29285176 )
2017
41
Difference in bilateral digital volume pulse as a novel non-invasive approach to assessing arteriosclerosis in aged and diabetic subjects: A preliminary study. ( 28467197 )
2017
42
Intima-Media Thickness in the Carotid and Femoral Arteries for Detection of Arteriosclerosis in Human Immunodeficiency Virus-Positive Individuals. ( 28146208 )
2017
43
The Association between Polymorphism of CARD8 rs2043211 and Susceptibility to Arteriosclerosis Obliterans in Chinese Han Male Population. ( 28135700 )
2017
44
The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis. ( 28569748 )
2017
45
National Dyslipidemia Registry of the Spanish Arteriosclerosis Society: Current status. ( 29102473 )
2017
46
Effect of sirolimus on arteriosclerosis induced by advanced glycation end products via inhibition of the ILK/mTOR pathway in kidney transplantation recipients. ( 28669853 )
2017
47
Sarcopenia and physical function are associated with inflammation and arteriosclerosis in community-dwelling people: The Yakumo study. ( 28741974 )
2017
48
Consensus document on the management of the atherogenic dyslipidaemia of the Spanish Society of Arteriosclerosis. ( 28185675 )
2017
49
Commonalities Between Vasculature and Bone: An Osseocentric View of Arteriosclerosis. ( 28115412 )
2017
50
Arteriosclerosis, Thrombosis, and Vascular Biology. ( 28062452 )
2017
Sources

Variations for Arteriosclerosis

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ClinVar genetic disease variations for Arteriosclerosis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 HS3ST1 NM_005114.2(HS3ST1): c.-108-6848A> G single nucleotide variant risk factor rs16881446 GRCh37 Chromosome 4, 11408585: 11408585
2 HS3ST1 NM_005114.2(HS3ST1): c.-108-6848A> G single nucleotide variant risk factor rs16881446 GRCh38 Chromosome 4, 11406961: 11406961
Sources

Expression for Arteriosclerosis

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Search GEO for disease gene expression data for Arteriosclerosis.
Sources

Pathways for Arteriosclerosis

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Pathways related to Arteriosclerosis according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Degradation of the extracellular matrix 67
Show member pathways
 12.58 ELN ICAM1 SERPINE1 SPP1 VCAM1
2
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 12.05 CCL2 ELN ICAM1 SPP1 VCAM1
3
Fluid shear stress and atherosclerosis 38
11.86 CCL2 EDN1 HMOX1 ICAM1 VCAM1
4
Statin Pathway 1
Show member pathways
 11.81 APOA1 APOB APOE HMGCR
5
Selenium Micronutrient Network 1
Show member pathways
 11.77 APOA1 APOB APOE CCL2 ICAM1 SERPINE1
6
Binding and Uptake of Ligands by Scavenger Receptors 67
Show member pathways
 11.76 APOA1 APOB APOE
7
Interleukin-4 and 13 signaling 67
11.76 CCL2 HMOX1 ICAM1 VCAM1
8
HIF-1 signaling pathway 38
11.73 EDN1 HMOX1 SERPINE1
9
TNF signaling pathway 38
11.7 CCL2 DAB2IP EDN1 ICAM1 VCAM1
10
PPAR signaling pathway 38
11.58 ADIPOQ APOA1 PPARG
11
AGE-RAGE signaling pathway in diabetic complications 38
11.55 CCL2 EDN1 ICAM1 SERPINE1 VCAM1
12
HIF-1-alpha transcription factor network 1
11.5 EDN1 HMOX1 SERPINE1
13
Malaria 38
11.36 CCL2 ICAM1 VCAM1
14
African trypanosomiasis 38
11.22 APOA1 ICAM1 VCAM1
15
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.16 CCL2 HMOX1 MGP
16
Lung fibrosis 1
10.82 CCL2 EDN1 ELN HMOX1 SPP1
17
LDL Oxidation in Atherogenesis 65
10.75 CCL2 ICAM1 VCAM1
Sources

GO Terms for Arteriosclerosis

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Cellular components related to Arteriosclerosis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 intracellular membrane-bounded organelle GO:0043231 9.93 APOB HMGCR HMOX1 PON1 PPARG
2 early endosome GO:0005769 9.89 APOA1 APOB APOE HSPD1 VCAM1
3 endoplasmic reticulum lumen GO:0005788 9.85 APOA1 APOB APOE SPP1
4 high-density lipoprotein particle GO:0034364 9.63 APOA1 APOE PON1
5 very-low-density lipoprotein particle GO:0034361 9.61 APOA1 APOB APOE
6 endocytic vesicle lumen GO:0071682 9.54 APOA1 APOB APOE
7 spherical high-density lipoprotein particle GO:0034366 9.52 APOA1 PON1
8 discoidal high-density lipoprotein particle GO:0034365 9.51 APOA1 APOE
9 low-density lipoprotein particle GO:0034362 9.5 APOA1 APOB APOE
10 collagen-containing extracellular matrix GO:0062023 9.5 ADIPOQ APOA1 APOE ELN ICAM1 MGP
11 extracellular space GO:0005615 9.44 ADIPOQ APOA1 APOB APOE CCL2 EDN1
12 chylomicron GO:0042627 9.43 APOA1 APOB APOE
13 intermediate-density lipoprotein particle GO:0034363 9.33 APOA1 APOB APOE
14 extracellular exosome GO:0070062 10.18 APOA1 APOB APOE HSPD1 ICAM1 MGP
15 extracellular region GO:0005576 10.14 ADIPOQ APOA1 APOB APOE CCL2 EDN1

Biological processes related to Arteriosclerosis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.99 APOA1 APOB APOE SPP1
2 cellular response to lipopolysaccharide GO:0071222 9.96 CCL2 DAB2IP ICAM1 SERPINE1
3 extracellular matrix organization GO:0030198 9.95 ELN ICAM1 SERPINE1 SPP1 VCAM1
4 steroid metabolic process GO:0008202 9.91 APOA1 APOB APOE HMGCR
5 negative regulation of inflammatory response GO:0050728 9.9 ADIPOQ APOA1 APOE
6 cellular response to interferon-gamma GO:0071346 9.9 CCL2 EDN1 ICAM1
7 response to ethanol GO:0045471 9.9 ADIPOQ HMGCR ICAM1 VCAM1
8 cholesterol homeostasis GO:0042632 9.89 APOA1 APOB APOE
9 regulation of lipid metabolic process GO:0019216 9.89 APOA1 HMGCR PPARG
10 regulation of blood pressure GO:0008217 9.86 EDN1 HMOX1 PPARG
11 positive regulation of smooth muscle cell proliferation GO:0048661 9.85 EDN1 HMGCR HMOX1
12 retinoid metabolic process GO:0001523 9.85 APOA1 APOB APOE
13 response to drug GO:0042493 9.85 ADIPOQ APOA1 EDN1 ICAM1 PPARG
14 cellular response to interleukin-1 GO:0071347 9.84 CCL2 DAB2IP EDN1 ICAM1
15 cholesterol biosynthetic process GO:0006695 9.82 APOA1 APOE HMGCR
16 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.82 ADIPOQ HMOX1 PPARG
17 response to nicotine GO:0035094 9.81 EDN1 HMOX1 VCAM1
18 negative regulation of neuron apoptotic process GO:0043524 9.81 APOE CCL2 HMOX1
19 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.79 HMOX1 ICAM1 SERPINE1
20 response to lipopolysaccharide GO:0032496 9.78 APOB EDN1 ICAM1 VCAM1
21 triglyceride catabolic process GO:0019433 9.77 APOA1 APOB APOE
22 cholesterol efflux GO:0033344 9.76 APOA1 APOB APOE
23 lipoprotein metabolic process GO:0042157 9.75 APOA1 APOB APOE
24 endothelial cell proliferation GO:0001935 9.74 APOA1 HMOX1
25 low-density lipoprotein particle clearance GO:0034383 9.74 ADIPOQ APOB HMOX1
26 high-density lipoprotein particle remodeling GO:0034375 9.73 APOA1 APOE
27 positive regulation of lipid biosynthetic process GO:0046889 9.73 APOA1 APOE
28 fatty acid oxidation GO:0019395 9.73 ADIPOQ PPARG
29 long-chain fatty acid transport GO:0015909 9.73 APOE PPARG
30 response to organic substance GO:0010033 9.73 APOB PPARG SPP1
31 low-density lipoprotein particle remodeling GO:0034374 9.72 APOB APOE
32 negative regulation of wound healing GO:0061045 9.72 HMGCR SERPINE1
33 high-density lipoprotein particle assembly GO:0034380 9.71 APOA1 APOE
34 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.71 ADIPOQ PPARG
35 phospholipid efflux GO:0033700 9.71 APOA1 APOE
36 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.71 ADIPOQ APOA1
37 negative regulation of hormone secretion GO:0046888 9.71 ADIPOQ EDN1
38 high-density lipoprotein particle clearance GO:0034384 9.7 APOA1 APOE
39 positive regulation of cholesterol esterification GO:0010873 9.7 APOA1 APOE
40 very-low-density lipoprotein particle remodeling GO:0034372 9.7 APOA1 APOE
41 negative regulation of blood coagulation GO:0030195 9.7 APOE EDN1 SERPINE1
42 chylomicron remnant clearance GO:0034382 9.69 APOB APOE
43 positive regulation of cholesterol efflux GO:0010875 9.69 ADIPOQ APOE PON1
44 regulation of Cdc42 protein signal transduction GO:0032489 9.68 APOA1 APOE
45 regulation of cholesterol transport GO:0032374 9.68 APOA1 APOE
46 negative regulation of cellular protein metabolic process GO:0032269 9.67 APOE EDN1
47 very-low-density lipoprotein particle clearance GO:0034447 9.67 APOB APOE
48 response to estrogen GO:0043627 9.67 APOA1 HMOX1 PPARG
49 negative regulation of MAP kinase activity GO:0043407 9.67 ADIPOQ APOE DAB2IP HMGCR
50 membrane to membrane docking GO:0022614 9.66 ICAM1 VCAM1

Molecular functions related to Arteriosclerosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.93 ADIPOQ APOE DAB2IP HMGCR HMOX1 PON1
2 cytokine activity GO:0005125 9.73 ADIPOQ CCL2 EDN1 SPP1
3 lipid binding GO:0008289 9.67 APOA1 APOE PPARG
4 protein-containing complex binding GO:0044877 9.56 APOE COG2 DAB2IP ICAM1
5 high-density lipoprotein particle binding GO:0008035 9.48 APOA1 HSPD1
6 lipoprotein particle binding GO:0071813 9.37 APOA1 APOE
7 lipid transporter activity GO:0005319 9.33 APOA1 APOB APOE
8 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.32 APOA1 APOE
9 phospholipid binding GO:0005543 9.26 APOA1 APOB APOE PON1
10 cholesterol transporter activity GO:0017127 8.8 APOA1 APOB APOE
11 protein binding GO:0005515 10.33 ADIPOQ APOA1 APOB APOE CCL2 COG2
Sources

Sources for Arteriosclerosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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