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MCID: ART021
MIFTS: 60

Arteriosclerosis

Categories: Cardiovascular diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Arteriosclerosis

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MalaCards integrated aliases for Arteriosclerosis:

Name: Arteriosclerosis 12 55 6 44 15 73
Arteriosclerotic Vascular Disease 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:2349
ICD10 33 I70
MeSH 44 D001161
NCIt 50 C34398
UMLS 73 C0003850
Sources

Summaries for Arteriosclerosis

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Disease Ontology : 12 An artery disease that is characterized by a thickening and hardening of arterial walls in the arteries.

MalaCards based summary : Arteriosclerosis, also known as arteriosclerotic vascular disease, is related to arteriosclerosis obliterans and ischemic heart disease, and has symptoms including angina pectoris An important gene associated with Arteriosclerosis is HS3ST1 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and Statin Pathway. The drugs Aspirin and Cilostazol have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and testes, and related phenotypes are Decreased free cholesterol and cardiovascular system

Wikipedia : 76 Arteriosclerosis is the thickening, hardening and loss of elasticity of the walls of arteries. This... more...

Sources

Related Diseases for Arteriosclerosis

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Diseases in the Arteriosclerosis family:

Arteriosclerosis, Severe Juvenile

Diseases related to Arteriosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 210)
# Related Disease Score Top Affiliating Genes
1 arteriosclerosis obliterans 34.9 ADIPOQ ICAM1 VCAM1
2 ischemic heart disease 33.0 APOA1 APOB APOE CRP
3 hyperlipoproteinemia, type iii 31.7 APOA1 APOB APOE COG2 HMGCR
4 angina pectoris 31.2 CRP EDN1 SERPINE1
5 ischemia 30.9 EDN1 HMOX1 ICAM1 PON1
6 vasculitis 30.8 CCL2 CRP ICAM1 VCAM1
7 coronary heart disease 1 30.8 ADIPOQ APOA1 APOB APOE COG2 CRP
8 peripheral artery disease 30.8 APOB CCL2 CRP VCAM1
9 apnea, obstructive sleep 30.7 ADIPOQ CRP EDN1
10 chronic venous insufficiency 30.7 ICAM1 SERPINE1 VCAM1
11 acute myocardial infarction 30.7 APOA1 CRP EDN1 SERPINE1
12 aortic aneurysm, familial abdominal, 1 30.7 APOE CCL2 CRP ELN
13 endocarditis 30.7 CRP HSPD1 VCAM1
14 takayasu arteritis 30.6 CRP PON1 VCAM1
15 venous insufficiency 30.6 CRP ICAM1 SERPINE1 VCAM1
16 hypertension, essential 30.5 ADIPOQ APOA1 APOB CRP EDN1 SERPINE1
17 peripheral vascular disease 30.3 APOA1 APOB CRP SERPINE1 VCAM1
18 kidney disease 30.3 APOE CCL2 CRP EDN1 MGP
19 atherosclerosis susceptibility 30.3 ADIPOQ APOA1 APOB APOE CCL2 CRP
20 pulmonary edema 30.3 CRP EDN1 HMOX1 ICAM1
21 chronic kidney failure 30.3 ADIPOQ CRP EDN1 HMGCR ICAM1 VCAM1
22 arcus corneae 30.2 APOA1 APOB APOE COG2
23 coronary artery anomaly 30.1 ADIPOQ APOA1 APOB APOE CCL2 COG2
24 sleep apnea 30.0 ADIPOQ APOE CRP EDN1 ICAM1
25 stroke, ischemic 29.5 APOB APOE COG2 CRP HMGCR PON1
26 heart disease 29.5 ADIPOQ APOA1 APOB APOE CRP EDN1
27 hypercholesterolemia, familial 29.3 APOA1 APOB APOE COG2 CRP HMGCR
28 diabetes mellitus 29.0 ADIPOQ APOA1 APOB COG2 CRP EDN1
29 myocardial infarction 28.7 ADIPOQ APOA1 APOB APOE CCL2 COG2
30 arteries, anomalies of 28.3 ADIPOQ APOA1 APOB APOE CCL2 COG2
31 diabetes mellitus, noninsulin-dependent 27.8 ADIPOQ APOA1 APOB APOE CCL2 COG2
32 vascular disease 26.5 ADIPOQ APOA1 APOB APOE CCL2 CRP
33 cerebral arteriosclerosis 12.4
34 monckeberg arteriosclerosis 12.3
35 intracranial arteriosclerosis 11.9
36 arteriosclerosis, severe juvenile 11.8
37 spinal cord infarction 11.0
38 malignant renovascular hypertension 11.0 EDN1 SERPINE1
39 arterial calcification of infancy 11.0
40 cerebral atherosclerosis 11.0
41 coronary artery aneurysm 11.0 ADIPOQ CCL2 VCAM1
42 dysbaric osteonecrosis 11.0 APOA1 APOB SERPINE1
43 subendocardial myocardial infarction 10.9 ICAM1 SERPINE1 VCAM1
44 post-thrombotic syndrome 10.9 CCL2 ICAM1 SERPINE1
45 shwartzman phenomenon 10.9 ICAM1 SERPINE1 VCAM1
46 abdominal obesity-metabolic syndrome 1 10.9 ADIPOQ PPARG SERPINE1
47 schimke immunoosseous dysplasia 10.9
48 werner syndrome 10.9
49 pleurisy 10.9 CCL2 CRP ICAM1
50 aortic atherosclerosis 10.8 APOE PON1 SPP1

Graphical network of the top 20 diseases related to Arteriosclerosis:



Diseases related to Arteriosclerosis
Sources

Symptoms & Phenotypes for Arteriosclerosis

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UMLS symptoms related to Arteriosclerosis:


angina pectoris

GenomeRNAi Phenotypes related to Arteriosclerosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.92 APOA1 APOB APOE HMGCR

MGI Mouse Phenotypes related to Arteriosclerosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.3 ICAM1 SPP1 MGP VCAM1 PON1 PPARG
2 homeostasis/metabolism MP:0005376 10.3 ICAM1 SPP1 MGP VCAM1 PON1 PPARG
3 growth/size/body region MP:0005378 10.28 SERPINE1 ICAM1 SPP1 MGP VCAM1 PPARG
4 cellular MP:0005384 10.17 HSPD1 ICAM1 SPP1 PON1 VCAM1 PPARG
5 immune system MP:0005387 10.06 SERPINE1 ICAM1 SPP1 VCAM1 PPARG CRP
6 mortality/aging MP:0010768 10 SERPINE1 ICAM1 SPP1 MGP VCAM1 PPARG
7 liver/biliary system MP:0005370 9.91 SERPINE1 SPP1 PPARG APOA1 HMGCR APOB
8 muscle MP:0005369 9.65 ICAM1 SPP1 MGP PPARG HSPD1 EDN1
9 renal/urinary system MP:0005367 9.23 SERPINE1 SPP1 MGP PPARG ADIPOQ EDN1
Sources

Drugs & Therapeutics for Arteriosclerosis

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Drugs for Arteriosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 875)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-78-2 2244
2
Cilostazol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 73963-72-1 2754
3
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-28-2 5757
4 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 979-32-8
5
Polyestradiol phosphate Approved Phase 4,Phase 2,Phase 3,Not Applicable 28014-46-2
6
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 57-83-0 5994
7
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 159351-69-6 6442177
8
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
9
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53123-88-9 5284616 6436030 46835353
10
Methyltestosterone Approved Phase 4,Phase 3,Phase 2,Not Applicable 58-18-4 6010
11
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 58-22-0 6013
12
Testosterone enanthate Approved Phase 4,Phase 3,Phase 2,Not Applicable 315-37-7 9416
13
Testosterone undecanoate Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 5949-44-0
14
Pravastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 81093-37-0 54687
15
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
16
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 120202-66-6, 113665-84-2 60606
17
Enalapril Approved, Vet_approved Phase 4,Phase 3,Phase 2 75847-73-3 5362032 40466924
18
Enalaprilat Approved Phase 4,Phase 3,Phase 2 76420-72-9 6917719
19
Rimonabant Approved, Investigational Phase 4,Phase 3,Not Applicable 168273-06-1, 158681-13-1 104850
20
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 79902-63-9 54454
21
Hydroxocobalamin Approved Phase 4,Phase 2,Phase 3,Not Applicable 13422-51-0 11953898 44475014
22
Paclitaxel Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 33069-62-4 36314
23
Fluvastatin Approved Phase 4,Phase 3,Not Applicable 93957-54-1 1548972
24
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 113775-47-6 68602 5311068
25
Etomidate Approved Phase 4 33125-97-2 36339 667484
26
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
27
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 71273 175805
28
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 28523-86-6 5206
29
Sufentanil Approved, Investigational Phase 4,Not Applicable 56030-54-7 41693
30
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-61-7 60961
31
Menthol Approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 2216-51-5 16666
32
Ticagrelor Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 274693-27-5 9871419
33
Ticlopidine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 55142-85-3 5472
34
Thrombin Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable
35
Vorapaxar Approved Phase 4,Phase 3,Phase 2 618385-01-6
36
Ezetimibe Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 163222-33-1 150311
37
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6 772 46507594
38
Tirofiban Approved Phase 4,Phase 3,Phase 1 144494-65-5 60947
39
Trimetazidine Approved, Investigational Phase 4 5011-34-7
40
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3 73590-58-6 4594
41
Pantoprazole Approved Phase 4,Phase 3 102625-70-7 4679
42
Lovastatin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 75330-75-5 53232
43
Chromium Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-47-3 27668
44
Metoprolol Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 37350-58-6, 51384-51-1 4171
45
Pitavastatin Approved Phase 4,Phase 3,Not Applicable 147511-69-1, 147526-32-7 6366718 5282452
46
Amlodipine Approved Phase 4,Phase 3,Not Applicable 88150-42-9 2162
47
Ranolazine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 142387-99-3, 95635-55-5 56959
48
Chlorhexidine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 55-56-1 9552079 2713
49
Esmolol Approved Phase 4,Phase 3,Not Applicable 103598-03-4, 81147-92-4 59768
50
Nicardipine Approved, Investigational Phase 4,Early Phase 1 55985-32-5 4474

Interventional clinical trials:

(show top 50) (show all 5708)
# Name Status NCT ID Phase Drugs
1 Sufficient Treatment of Peripheral Intervention by Cilostazol Unknown status NCT00912756 Phase 4 cilostazol
2 Kronos Early Estrogen Prevention Study (KEEPS) Unknown status NCT00154180 Phase 4 Conjugated equine estrogens 0.45 mg/day;Transdermal estradiol, 50 mcg/day;Micronized progesterone, 200 mg/day x 12 d/month;CEE , progesterone, estradiol patch or placebo for each;CEE, progesterone, transdermal patch or the placebo
3 Study to Investigate the Effect of Heart Rate Reduction With Ivabradine on Vascular Elastic Properties and Endothelial Function in Patients With Stable Coronary Heart Disease Unknown status NCT01768585 Phase 4 Ivabradine;Placebo
4 The Low HDL On Six Weeks Statin Therapy (LOW) Study Unknown status NCT00238004 Phase 4 Nicotinic acid
5 Effect of Short Term Atorvastatin Treatment,80mg/Day on Early Regression of Carotid Artery Atherosclerotic Lesions Unknown status NCT00640744 Phase 4 Atorvastatin
6 Fibrosis in Renal Allografts Unknown status NCT00493194 Phase 4 sirolimus;cyclosporine;daclizumab
7 Testosterone Therapy on Angina Threshold and Atheroma in Patients With Chronic Stable Angina Unknown status NCT00131183 Phase 4 Nebido
8 Fractional Flow Reserve Versus Angiography Randomization for Graft Optimization Trial Unknown status NCT02477371 Phase 4
9 The Effects of Pravastatin and Rosuvastatin on Coronary Plaques in Patients With Stable Angina Pectoris Unknown status NCT01325818 Phase 4 pravastatin, rosuvastatin
10 Does Rosuvastatin Delay Progression of Atherosclerosis in HIV Unknown status NCT01813357 Phase 4 Rosuvastatin
11 Early Detection of Atherosclerosis: a Randomized Trial in the Primary Prevention of Cardiovascular Diseases. Unknown status NCT00734123 Phase 4 Simvastatin or Atorvastatin;Enalapril;Aspirin or clopidogrel;Rimonabant
12 Homocysteine Lowering and Atherosclerosis Reduction Trial (HART) Unknown status NCT00217178 Phase 4 Vitamins: Folic acid, B6, B12
13 Vitamin K2 and Vessel Calcification in Chronic Kidney Disease Patients Unknown status NCT01101698 Phase 4 Vitamin K2+10μg cholecalciferol;Vitamin D
14 Paclitaxel Eluting Stent or Exercise for Thigh Atherosclerosis Unknown status NCT02033135 Phase 4
15 Efficacy of Self-Expanding Nitinol S.M.A.R.T CONTROL Stent Versus Life Stent For The Atherosclerotic Femoro-Popliteal Arterial Disease Unknown status NCT01653600 Phase 4
16 The Effect of Vitamin A on Atherosclerosis Unknown status NCT01414972 Phase 4 Vitamin A;placebo
17 The Study of the Effects of Vitamin A on Immune System in Patients With Atherosclerosis Unknown status NCT00963222 Phase 4 vitamin A;placebo
18 The Effect of Dates on Plasma Lipids, Oxidative Stress and the Atherogenicity of Serum in Healthy Adults Unknown status NCT00750789 Phase 4
19 Fluvastatin AmelIorates aTHerosclerosis Study Unknown status NCT01681199 Phase 4 Fluvastatin extended release tablet
20 The ABC Trial Does All-Blood Cardioplegia Prevent Blood Transfusion in Cardiac Surgery? A Single Centre Pilot Study Unknown status NCT01623193 Phase 4
21 Studies of Application of Combined General Anesthesia and Bilateral TPVB in OPCABG Unknown status NCT02727712 Phase 4 Anesthesia drugs during the surgery
22 The Effect of a Natural Polyphenolic Extract From Pomegrnate (POMX) on the Development of Atherosclerosis in Diabetic Patients Unknown status NCT00470808 Phase 4 POMx
23 ATHERO: Advanced Technology Halting Early Re-Stenosis and Occlusion Unknown status NCT00407940 Phase 4
24 Endothelial Dysfunction in Subjects With History of Premature Coronary Artery Disease Unknown status NCT00917527 Phase 4 Atorvastatin
25 Relation Among Shear Stress Distribution, Stent Design, and Subsequent Vessel Healing After Drug-eluting Stent Implantation (SHEAR DES) Unknown status NCT01942044 Phase 4
26 Effects of REnal Denervation for Resistant Hypertension on Exercise Diastolic Function and Regression of Atherosclerosis and the Evaluation of NEW Methods Predicting A successfuL Renal Sympathetic Denervation (RENEWAL-EXERCISE, -REGRESS, and -PREDICT Tria Unknown status NCT01918111 Phase 4 adenosine infusion treatment
27 Danshen Dropping Pill for Coronary Heart Disease Heart and Artery Structure and Function Unknown status NCT01825759 Phase 4 danshen dripping pill
28 Clinical Evaluation of Magnetic Resonance Imaging in Coronary Heart Disease-2 Unknown status NCT01664858 Phase 4
29 Intracoronary Stenting and Antithrombotic Regimen: ADjusting Antiplatelet Treatment in PatienTs Based on Platelet Function Testing Unknown status NCT01456364 Phase 4 Ticagrelor;Prasugrel
30 Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis - SAfety & EffectiveneSS of Drug-ElUting Stents & Anti-platelet REgimen Unknown status NCT01267734 Phase 4 Triple anti-platelet therapy (TAT);Double-dose clopidogrel anti-platelet therapy (DDAT)
31 Test of Long-Term Safety and Efficacy of Sirolimus-Permanent-Polymer Eluting Stent (Cypher)- and Sirolimus-Polymer-free Eluting Stents (PPS/PFS) Assessed by Optical Coherence Tomography Unknown status NCT01260558 Phase 4
32 Test Safety and Efficacy of Zotarolimus- and Everolimus-Eluting Stents (ZES/EES) Assessed by Optical Coherence Tomography Unknown status NCT01230723 Phase 4
33 Paclitaxel Eluting Balloon and Conventional Balloon for In-Stent Restenosis of the Superficial Femoral Artery Unknown status NCT01083394 Phase 4
34 Test Efficacy of Biodegradable and Permanent Limus-Eluting Stents Unknown status NCT01068106 Phase 4
35 Efficacy Study of Stenting, Paclitaxel Eluting Balloon or Atherectomy to Treat Peripheral Artery Disease Unknown status NCT00986752 Phase 4
36 Intensive Rosuvastatin Therapy on Cerebral Hemodynamics in Patients With Atherosclerotic Intracranial Arterial Stenosis Unknown status NCT02594800 Phase 4 Rosuvastatin
37 A Multicenter, Therapeutic Used Study to Evaluate the Efficacy and Safety of Pletaal SR Capsule (Cilostazol) in Subjects With Peripheral Arterial Disease Symptom Due to Chronic Occlusive Arterial Disease Unknown status NCT01711333 Phase 4 Pletaal SR capsule
38 Residual Platelet Activity In Advanced Peripheral Artery Disease Unknown status NCT01627431 Phase 4 Acetylsalicylic acid;Clopidogrel
39 Periodontal Therapy in Coronary Artery Patients Unknown status NCT01609725 Phase 4
40 Influence of Vorapaxar on Thrombin Generation and Coagulability Unknown status NCT02629367 Phase 4 Vorapaxar;Asprin;Clopidogrel
41 Ezetimibe and Atorvastatin Therapy on TCFA Unknown status NCT02588235 Phase 4 Ezetimibe and Atorvastatin;Atorvastatin
42 Safety and Efficacy of Low-dose Ticagrelor in Chinese Patients With Stable Coronary Artery Disease Unknown status NCT02514642 Phase 4 low-dose ticagrelor;Clopidogrel
43 Plasma and Platelet microRNAs in Clopidogrel Low Response Patients Unknown status NCT02447809 Phase 4 Clopidogrel;acetylsalicylic acid (ASA)
44 Efficacy and Safety of Different Dose of Tirofiban in Interventional Treatment of Complex Coronary Artery Disease Unknown status NCT02294994 Phase 4 tirofiban
45 Effect of Cilostazol on Endothelial Progenitor Cells and Endothelial Function in Coronary Artery Disease Unknown status NCT02174939 Phase 4 Cilostazol;Dummy Placebo
46 In Vitro and In Vivo Comparison Between Intravascular Ultrasound (IVUS) Systems Unknown status NCT02154295 Phase 4
47 The ImPact of Trimetazidine on MicrOcirculation After Stenting for Stable Coronary Artery Disease Unknown status NCT02107144 Phase 4 trimetazidine
48 Pharmacodynamic Comparison of Rosuvastatin Versus Atorvastatin on Platelet Reactivity in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy With New P2Y12 Inhibitors (Trial gRANADa) Unknown status NCT02030054 Phase 4 Atorvastatin;Rosuvastatin
49 "Pharmacodynamic Comparison of Omeprazole Versus Pantoprazole on Platelet Reactivity in Patients With Acute Coronary Syndromes on Dual Antiplatelet Therapy With New P2Y12 Inhibitors" -Trial dOPPLER- Unknown status NCT02028234 Phase 4 Pantoprazole,;Omeprazole
50 Potential Impact of Cigarette Smoking on Platelet Reactivity in Patients on Dual Antiplatelet Therapy With P2Y12 Inhibitors Unknown status NCT02026713 Phase 4

Search NIH Clinical Center for Arteriosclerosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: arteriosclerosis

Sources

Genetic Tests for Arteriosclerosis

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Sources

Anatomical Context for Arteriosclerosis

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MalaCards organs/tissues related to Arteriosclerosis:

41
Heart, Endothelial, Testes, Bone, Kidney, Bone Marrow, Monocytes
Sources

Publications for Arteriosclerosis

About this section

Articles related to Arteriosclerosis:

(show top 50) (show all 1075)
# Title Authors Year
1
The differentiation of mesenchymal stem cells to vascular cells regulated by the HMGB1/RAGE axis: its application in cell therapy for transplant arteriosclerosis. ( 29615103 )
2018
2
Pulsatile flow of non-Newtonian blood fluid inside stenosed arteries: Investigating the effects of viscoelastic and elastic walls, arteriosclerosis, and polycythemia diseases. ( 29249336 )
2018
3
Spontaneously occurring intramural coronary arteriosclerosis in regularly slaughtered veal calves and beef cattle: aA screening study about prevalence and histopathological features. ( 29371083 )
2018
4
Graft protective effect and induction of CD4<sup>+</sup>Foxp3<sup>+</sup> cell by Thrombomodulin on allograft arteriosclerosis in mice. ( 29783997 )
2018
5
Clipping treatment of posterior communicating artery aneurysms associated with arteriosclerosis and calcification: A single center study of 136 cases. ( 29434749 )
2018
6
MicroRNA-31 promotes arterial smooth muscle cell proliferation and migration by targeting mitofusin-2 in arteriosclerosis obliterans of the lower extremitie. ( 29403548 )
2018
7
Retinal vessel narrowing: an early predictor of future arteriosclerosis? ( 29384985 )
2018
8
Arteriosclerosis Is a Major Predictor of Small Bowel Vascular Lesions. ( 29372478 )
2018
9
Increased plasma olfactomedin 2 after interventional therapy is a predictor for restenosis in lower extremity arteriosclerosis obliterans patients. ( 29553861 )
2018
10
Pronounced Coronary Arteriosclerosis in Cirrhosis: Influence on Cardiac Function and Survival? ( 29516327 )
2018
11
Night-time activation of the intrarenal renin-angiotensin system due to nocturnal hypertension is associated with renal arteriosclerosis in normotensive IgA nephropathy patients. ( 29507351 )
2018
12
Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study. ( 29382349 )
2018
13
Accelerated atheromatosis and arteriosclerosis in primary systemic vasculitides: current evidence and future perspectives. ( 29040156 )
2018
14
Role of Resident Stem Cells in Vessel Formation and Arteriosclerosis. ( 29798903 )
2018
15
Response by Daugherty et al to Letter Regarding Article, &amp;quot;Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies: A Statement From the <i>Arteriosclerosis, Thrombosis, and Vascular Biology</i> Council&amp;quot;. ( 29793996 )
2018
16
Arteriosclerosis, Thrombosis, and Vascular Biology. ( 29282242 )
2018
17
Assessment of Subtle Changes in Diabetes-Associated Arteriosclerosis using Photoplethysmographic Pulse Wave from Index Finger. ( 29368039 )
2018
18
Arteriosclerosis in Brazil. Findings from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). ( 29791607 )
2018
19
Letter by Ramirez and Hibbert Regarding Article, &amp;quot;Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies: A Statement From the <i>Arteriosclerosis, Thrombosis, and Vascular Biology</i> Council&amp;quot;. ( 29793995 )
2018
20
Circulating odd-chain saturated fatty acids were associated with arteriosclerosis among patients with diabetes, dyslipidemia, or hypertension in Sri Lanka but not Japan. ( 29540275 )
2018
21
Association of arteriosclerosis and/or atherosclerosis with hypertensive target organ damage in the community-dwelling elderly Chinese: the Northern Shanghai Study. ( 28652715 )
2017
22
Efficacy of continuous positive airway pressure treatment in treating obstructive sleep apnea hypopnea syndrome associated with carotid arteriosclerosis. ( 29285176 )
2017
23
Difference in bilateral digital volume pulse as a novel non-invasive approach to assessing arteriosclerosis in aged and diabetic subjects: A preliminary study. ( 28467197 )
2017
24
Intima-Media Thickness in the Carotid and Femoral Arteries for Detection of Arteriosclerosis in Human Immunodeficiency Virus-Positive Individuals. ( 28146208 )
2017
25
The Association between Polymorphism of CARD8 rs2043211 and Susceptibility to Arteriosclerosis Obliterans in Chinese Han Male Population. ( 28135700 )
2017
26
The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis. ( 28569748 )
2017
27
National Dyslipidemia Registry of the Spanish Arteriosclerosis Society: Current status. ( 29102473 )
2017
28
Effect of sirolimus on arteriosclerosis induced by advanced glycation end products via inhibition of the ILK/mTOR pathway in kidney transplantation recipients. ( 28669853 )
2017
29
Sarcopenia and physical function are associated with inflammation and arteriosclerosis in community-dwelling people: The Yakumo study. ( 28741974 )
2017
30
Consensus document on the management of the atherogenic dyslipidaemia of the Spanish Society of Arteriosclerosis. ( 28185675 )
2017
31
Commonalities Between Vasculature and Bone: An Osseocentric View of Arteriosclerosis. ( 28115412 )
2017
32
Arteriosclerosis, Thrombosis, and Vascular Biology. ( 28062452 )
2017
33
WITHDRAWN: What exactly, regression of atherosclerosis or foreign body reaction with hyaline arteriosclerosis, drives transient scaffolding of coronary arteries? A pooled analysis of observational ABSORB studies with a serial multimodality imaging substudy of ABSORB cohort B1 trial. ( 28629625 )
2017
34
Diffuse Carotid Arteriosclerosis and Stroke in a Patient With Schimke Immuno-osseous Dysplasia. ( 28412018 )
2017
35
Decalogue of the Spanish Society of Arteriosclerosis to reduce therapeutic inertia. ( 28844490 )
2017
36
Role of TLR4 and miR-155 in peripheral blood mononuclear cell-mediated inflammatory reaction in coronary slow flow and coronary arteriosclerosis patients. ( 28407320 )
2017
37
Potential Effects of Desalinated Seawater on Arteriosclerosis in Rats. ( 29122097 )
2017
38
Blood pressure, heart rate, and double product in a pooled cohort: the Japan Arteriosclerosis Longitudinal Study. ( 28486272 )
2017
39
Joint position statement on &amp;quot;Nutraceuticals for the treatment of hypercholesterolemia&amp;quot; of the Italian Society of Diabetology (SID) and of the Italian Society for the Study of Arteriosclerosis (SISA). ( 27956024 )
2017
40
Mir-22-3p Inhibits Arterial Smooth Muscle Cell Proliferation and Migration and Neointimal Hyperplasia by Targeting HMGB1 in Arteriosclerosis Obliterans. ( 28848136 )
2017
41
The role of sildenafil in the development of transplant arteriosclerosis in rat aortic grafts. ( 29218089 )
2017
42
Vaccine against arteriosclerosis: an update. ( 28515939 )
2017
43
Mice, vaccine, and human arteriosclerosis. ( 29145664 )
2017
44
Monckeberg Arteriosclerosis: AA TelltaleA Sign. ( 28499804 )
2017
45
Baseline Characterization of Japanese Peripheral Arterial Disease Patientsa88- Analysis of Surveillance of Cardiovascular Events in Antiplatelet-Treated Arteriosclerosis Obliterans Patients in Japan (SEASON). ( 26841805 )
2016
46
APOL1 Risk Alleles are Associated with More Severe Arteriosclerosis in Renal Resistance Vessels with Aging and Hypertension. ( 27610422 )
2016
47
A Rare Complication of Spinal Cord Ischemia Following Endovascular Aneurysm Repair of an Infrarenal Abdominal Aortic Aneurysm with Arteriosclerosis Obliterans: Report of a Case. ( 27738476 )
2016
48
Arteriosclerosis in the ventral aorta and epicarditis in the bulbus arteriosus of Atlantic salmon (Salmo salar L). ( 27723105 )
2016
49
Relationship Of Visceral Fat Accumulation And Arteriosclerosis Risk In Obese Children: 3573 Board #12 June 4, 8: 00 AM - 9: 30 AM. ( 27361939 )
2016
50
Prolyl-hydroxylase inhibitor activating hypoxia-inducible transcription factors reduce levels of transplant arteriosclerosis in a murine aortic allograft model. ( 26819270 )
2016
Sources

Variations for Arteriosclerosis

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ClinVar genetic disease variations for Arteriosclerosis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 HS3ST1 NM_005114.2(HS3ST1): c.-108-6848A> G single nucleotide variant risk factor rs16881446 GRCh37 Chromosome 4, 11408585: 11408585
2 HS3ST1 NM_005114.2(HS3ST1): c.-108-6848A> G single nucleotide variant risk factor rs16881446 GRCh38 Chromosome 4, 11406961: 11406961
Sources

Expression for Arteriosclerosis

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Search GEO for disease gene expression data for Arteriosclerosis.
Sources

Pathways for Arteriosclerosis

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Pathways related to Arteriosclerosis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Degradation of the extracellular matrix 66
Show member pathways
 12.58 ELN ICAM1 SERPINE1 SPP1 VCAM1
2
Statin Pathway 1
Show member pathways
 11.81 APOA1 APOB APOE HMGCR
3
Fluid shear stress and atherosclerosis 37
11.8 CCL2 EDN1 HMOX1 ICAM1 VCAM1
4
Interleukin-4 and 13 signaling 66
11.76 CCL2 HMOX1 ICAM1 VCAM1
5
Binding and Uptake of Ligands by Scavenger Receptors 66
Show member pathways
 11.75 APOA1 APOB APOE
6
HIF-1 signaling pathway 37
11.72 EDN1 HMOX1 SERPINE1
7
TNF signaling pathway 37
11.7 CCL2 EDN1 ICAM1 VCAM1
8
PPAR signaling pathway 37
11.57 ADIPOQ APOA1 PPARG
9
AGE-RAGE signaling pathway in diabetic complications 37
11.55 CCL2 EDN1 ICAM1 SERPINE1 VCAM1
10
HIF-1-alpha transcription factor network 1
11.5 EDN1 HMOX1 SERPINE1
11
Folate Metabolism 1
Show member pathways
 11.5 APOA1 APOB APOE CCL2 CRP ICAM1
12
Malaria 37
11.36 CCL2 ICAM1 VCAM1
13
African trypanosomiasis 37
11.2 APOA1 ICAM1 VCAM1
14
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.16 CCL2 HMOX1 MGP
15
Lung fibrosis 1
11.15 CCL2 EDN1 ELN HMOX1 SPP1
16
LDL Oxidation in Atherogenesis 64
10.7 CCL2 ICAM1 VCAM1
Sources

GO Terms for Arteriosclerosis

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Cellular components related to Arteriosclerosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 early endosome GO:0005769 9.89 APOA1 APOB APOE HSPD1 VCAM1
2 endoplasmic reticulum lumen GO:0005788 9.84 APOA1 APOB APOE SPP1
3 high-density lipoprotein particle GO:0034364 9.65 APOA1 APOE PON1
4 very-low-density lipoprotein particle GO:0034361 9.63 APOA1 APOB APOE
5 extracellular matrix GO:0031012 9.63 APOA1 APOE ELN ICAM1 MGP SERPINE1
6 endocytic vesicle lumen GO:0071682 9.61 APOA1 APOB APOE
7 low-density lipoprotein particle GO:0034362 9.58 APOA1 APOB APOE
8 spherical high-density lipoprotein particle GO:0034366 9.52 APOA1 PON1
9 discoidal high-density lipoprotein particle GO:0034365 9.51 APOA1 APOE
10 chylomicron GO:0042627 9.5 APOA1 APOB APOE
11 extracellular space GO:0005615 9.47 ADIPOQ APOA1 APOB APOE CCL2 CRP
12 intermediate-density lipoprotein particle GO:0034363 9.13 APOA1 APOB APOE
13 extracellular exosome GO:0070062 10.15 ADIPOQ APOA1 APOB APOE CRP HSPD1
14 extracellular region GO:0005576 10.03 ADIPOQ APOA1 APOB APOE CCL2 CRP

Biological processes related to Arteriosclerosis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.97 APOB EDN1 ICAM1 VCAM1
2 response to organic substance GO:0010033 9.9 APOB PPARG SPP1
3 cellular response to interferon-gamma GO:0071346 9.9 CCL2 EDN1 ICAM1
4 regulation of lipid metabolic process GO:0019216 9.9 APOA1 HMGCR PPARG
5 extracellular matrix organization GO:0030198 9.89 ELN ICAM1 SERPINE1 SPP1 VCAM1
6 cholesterol homeostasis GO:0042632 9.88 APOA1 APOB APOE
7 cellular response to interleukin-1 GO:0071347 9.88 CCL2 EDN1 ICAM1
8 steroid metabolic process GO:0008202 9.88 APOA1 APOB APOE HMGCR
9 regulation of blood pressure GO:0008217 9.87 EDN1 HMOX1 PPARG
10 response to ethanol GO:0045471 9.87 ADIPOQ HMGCR ICAM1 VCAM1
11 negative regulation of inflammatory response GO:0050728 9.86 ADIPOQ APOA1 APOE PPARG
12 response to estrogen GO:0043627 9.85 APOA1 HMOX1 PPARG
13 retinoid metabolic process GO:0001523 9.85 APOA1 APOB APOE
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.83 EDN1 HMGCR HMOX1
15 response to hypoxia GO:0001666 9.83 ADIPOQ EDN1 HMOX1 ICAM1 VCAM1
16 response to nicotine GO:0035094 9.81 EDN1 HMOX1 VCAM1
17 cholesterol biosynthetic process GO:0006695 9.81 APOA1 APOE HMGCR
18 negative regulation of MAP kinase activity GO:0043407 9.8 ADIPOQ APOE HMGCR
19 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.78 HMOX1 ICAM1 SERPINE1
20 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.75 ADIPOQ HMOX1 PPARG
21 positive regulation of lipid biosynthetic process GO:0046889 9.73 APOA1 APOE
22 fatty acid oxidation GO:0019395 9.73 ADIPOQ PPARG
23 phosphatidylcholine metabolic process GO:0046470 9.72 APOA1 PON1
24 negative regulation of wound healing GO:0061045 9.72 HMGCR SERPINE1
25 high-density lipoprotein particle assembly GO:0034380 9.72 APOA1 APOE
26 triglyceride catabolic process GO:0019433 9.72 APOA1 APOB APOE
27 cellular response to tumor necrosis factor GO:0071356 9.72 APOB CCL2 EDN1 ICAM1 VCAM1
28 low-density lipoprotein particle remodeling GO:0034374 9.71 APOB APOE
29 long-chain fatty acid transport GO:0015909 9.71 APOE PPARG
30 phospholipid efflux GO:0033700 9.71 APOA1 APOE
31 cholesterol efflux GO:0033344 9.71 APOA1 APOB APOE
32 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.7 ADIPOQ APOA1
33 negative regulation of blood vessel diameter GO:0097756 9.7 CRP HMGCR
34 low-density lipoprotein particle clearance GO:0034383 9.7 ADIPOQ APOB HMOX1
35 very-low-density lipoprotein particle remodeling GO:0034372 9.69 APOA1 APOE
36 positive regulation of cholesterol esterification GO:0010873 9.69 APOA1 APOE
37 high-density lipoprotein particle clearance GO:0034384 9.69 APOA1 APOE
38 lipoprotein metabolic process GO:0042157 9.69 APOA1 APOB APOE
39 negative regulation of hormone secretion GO:0046888 9.68 ADIPOQ EDN1
40 neuron projection regeneration GO:0031102 9.68 APOA1 APOE
41 chylomicron remnant clearance GO:0034382 9.67 APOB APOE
42 regulation of cholesterol transport GO:0032374 9.66 APOA1 APOE
43 regulation of Cdc42 protein signal transduction GO:0032489 9.66 APOA1 APOE
44 negative regulation of cellular protein metabolic process GO:0032269 9.65 APOE EDN1
45 very-low-density lipoprotein particle clearance GO:0034447 9.65 APOB APOE
46 positive regulation of cholesterol efflux GO:0010875 9.65 ADIPOQ APOE PON1
47 membrane to membrane docking GO:0022614 9.64 ICAM1 VCAM1
48 negative regulation of blood coagulation GO:0030195 9.63 APOE EDN1 SERPINE1
49 lipoprotein catabolic process GO:0042159 9.62 APOB APOE
50 adhesion of symbiont to host GO:0044406 9.62 HSPD1 ICAM1

Molecular functions related to Arteriosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.76 ADIPOQ CCL2 EDN1 SPP1
2 phospholipid binding GO:0005543 9.56 APOA1 APOB APOE PON1
3 high-density lipoprotein particle binding GO:0008035 9.43 APOA1 HSPD1
4 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.4 APOA1 APOE
5 lipoprotein particle binding GO:0071813 9.37 APOA1 APOE
6 lipid transporter activity GO:0005319 9.33 APOA1 APOB APOE
7 low-density lipoprotein particle receptor binding GO:0050750 9.13 APOB APOE CRP
8 cholesterol transporter activity GO:0017127 8.8 APOA1 APOB APOE
9 protein binding GO:0005515 10.28 ADIPOQ APOA1 APOB APOE CCL2 COG2
Sources

Sources for Arteriosclerosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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