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MCID: ART021
MIFTS: 57

Arteriosclerosis

Categories: Cardiovascular diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Arteriosclerosis

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MalaCards integrated aliases for Arteriosclerosis:

Name: Arteriosclerosis 12 55 6 44 15 73
Arteriosclerotic Vascular Disease 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:2349
ICD10 33 I70
MeSH 44 D001161
NCIt 50 C34398
SNOMED-CT 68 28960008 72092001
UMLS 73 C0003850
Sources

Summaries for Arteriosclerosis

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Disease Ontology : 12 An artery disease that is characterized by a thickening and hardening of arterial walls in the arteries.

MalaCards based summary : Arteriosclerosis, also known as arteriosclerotic vascular disease, is related to arteriosclerosis obliterans and ischemic heart disease, and has symptoms including angina pectoris An important gene associated with Arteriosclerosis is HS3ST1 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins. The drugs Aspirin and Cilostazol have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and kidney, and related phenotypes are Decreased free cholesterol and cardiovascular system

Wikipedia : 76 Arteriosclerosis is the thickening, hardening, and loss of elasticity of the walls of arteries. This... more...

Sources

Related Diseases for Arteriosclerosis

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Diseases in the Arteriosclerosis family:

Arteriosclerosis, Severe Juvenile

Diseases related to Arteriosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 229)
# Related Disease Score Top Affiliating Genes
1 arteriosclerosis obliterans 34.2 ADIPOQ ICAM1 VCAM1
2 ischemic heart disease 32.5 CRP CCL2 APOE APOB APOA1
3 coronary artery anomaly 32.2 SERPINE1 PON1 HMGCR EDN1 CRP COG2
4 coronary heart disease 1 31.7 SERPINE1 PON1 HS3ST1 HMGCR EDN1 CRP
5 hyperlipoproteinemia, type iii 31.6 HMGCR COG2 APOE APOB APOA1
6 atherosclerosis susceptibility 31.2 VCAM1 SERPINE1 PPARG PON1 ICAM1 CRP
7 ischemia 30.8 EDN1 HMOX1 ICAM1 PON1
8 takayasu arteritis 30.3 CRP PON1 VCAM1
9 vasculitis 30.3 CCL2 CRP ICAM1 VCAM1
10 aortic aneurysm, familial abdominal, 1 30.2 APOE CCL2 CRP ELN
11 heart disease 30.2 SERPINE1 PON1 ICAM1 ELN EDN1 CRP
12 endocarditis 30.1 CRP HSPD1 VCAM1
13 diabetes mellitus 30.1 SERPINE1 PPARG PON1 HSPD1 HMGCR EDN1
14 chronic kidney failure 30.0 VCAM1 SPP1 PON1 ICAM1 HMGCR EDN1
15 chronic venous insufficiency 30.0 ICAM1 SERPINE1 VCAM1
16 kidney disease 30.0 SPP1 SERPINE1 MGP HMOX1 HMGCR EDN1
17 venous insufficiency 30.0 CRP ICAM1 SERPINE1 VCAM1
18 carotid stenosis 29.9 APOE CRP SPP1
19 hypertension, essential 29.9 ADIPOQ APOA1 APOB CRP EDN1 PON1
20 myocardial infarction 29.9 SERPINE1 PON1 ICAM1 HMGCR EDN1 CRP
21 peripheral vascular disease 29.9 APOA1 APOB CRP SERPINE1 VCAM1
22 pulmonary edema 29.9 CRP EDN1 HMOX1 ICAM1
23 pseudoxanthoma elasticum 29.9 ELN MGP SPP1
24 acute myocardial infarction 29.8 APOA1 APOB CRP EDN1 SERPINE1
25 arcus corneae 29.8 APOA1 APOB APOE COG2
26 stroke, ischemic 29.8 COG2 CRP HMGCR PON1 SERPINE1 APOE
27 sleep apnea 29.8 ADIPOQ APOE CRP EDN1 ICAM1
28 lipid metabolism disorder 29.7 SERPINE1 PPARG HMGCR CRP COG2 APOE
29 arteries, anomalies of 29.7 VCAM1 SERPINE1 PPARG PON1 ICAM1 EDN1
30 coronary stenosis 29.6 SERPINE1 PON1 ICAM1 CRP APOE APOB
31 hypercholesterolemia, familial 29.6 PON1 HMGCR CRP COG2 APOE APOB
32 diabetes mellitus, noninsulin-dependent 29.5 VCAM1 SERPINE1 PPARG PON1 HMGCR EDN1
33 vascular disease 29.1 VCAM1 SERPINE1 PPARG PON1 MGP HSPD1
34 cerebral arteriosclerosis 12.5
35 monckeberg arteriosclerosis 12.4
36 intracranial arteriosclerosis 12.1
37 arteriosclerosis, severe juvenile 12.0
38 spinal cord infarction 11.2
39 arterial calcification of infancy 11.1
40 cerebral atherosclerosis 11.1
41 schimke immunoosseous dysplasia 11.1
42 werner syndrome 11.1
43 retinopathy, arteriosclerotic 11.0
44 malignant hypertensive renal disease 10.3 EDN1 SERPINE1
45 malignant renovascular hypertension 10.3 EDN1 SERPINE1
46 coronary artery aneurysm 10.3 ADIPOQ CCL2 VCAM1
47 subendocardial myocardial infarction 10.3 ICAM1 SERPINE1 VCAM1
48 post-thrombotic syndrome 10.3 CCL2 ICAM1 SERPINE1
49 apnea, obstructive sleep 10.3 ADIPOQ CRP EDN1
50 thrombosis 10.3

Graphical network of the top 20 diseases related to Arteriosclerosis:



Diseases related to Arteriosclerosis
Sources

Symptoms & Phenotypes for Arteriosclerosis

About this section

UMLS symptoms related to Arteriosclerosis:


angina pectoris

GenomeRNAi Phenotypes related to Arteriosclerosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.92 APOA1 APOB APOE HMGCR

MGI Mouse Phenotypes related to Arteriosclerosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.3 ADIPOQ APOA1 APOB APOE CRP EDN1
2 homeostasis/metabolism MP:0005376 10.3 ADIPOQ APOA1 APOB APOE COG2 CRP
3 growth/size/body region MP:0005378 10.28 ADIPOQ APOB APOE COG2 EDN1 HMGCR
4 cellular MP:0005384 10.17 ADIPOQ APOA1 APOB APOE HMOX1 HSPD1
5 immune system MP:0005387 10.06 ADIPOQ APOB APOE CCL2 CRP HMOX1
6 mortality/aging MP:0010768 10 ADIPOQ APOB APOE EDN1 HMGCR HMOX1
7 liver/biliary system MP:0005370 9.91 ADIPOQ APOA1 APOB APOE HMGCR HMOX1
8 muscle MP:0005369 9.65 ADIPOQ APOB APOE EDN1 HMOX1 HSPD1
9 renal/urinary system MP:0005367 9.23 ADIPOQ APOE EDN1 HMOX1 MGP PPARG
Sources

Drugs & Therapeutics for Arteriosclerosis

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Drugs for Arteriosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 899)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-78-2 2244
2
Cilostazol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 73963-72-1 2754
3 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 979-32-8
4
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 57-83-0 5994
5
Polyestradiol phosphate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 28014-46-2
6
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-28-2 5757
7
Nicotinamide Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 98-92-0 936
8
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
9
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53123-88-9 46835353 6436030 5284616
10
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 159351-69-6 6442177
11
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 113665-84-2, 120202-66-6 60606
12
Ticlopidine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 55142-85-3 5472
13
Testosterone enanthate Approved Phase 4,Phase 3,Phase 2,Not Applicable 315-37-7 9416
14
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 58-22-0 6013
15
Testosterone undecanoate Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 5949-44-0
16
Methyltestosterone Approved Phase 4,Phase 3,Phase 2,Not Applicable 58-18-4 6010
17
Pravastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 81093-37-0 54687
18
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
19 tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20
Rimonabant Approved, Investigational Phase 4,Phase 3,Not Applicable 158681-13-1, 168273-06-1 104850
21
Enalapril Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 75847-73-3 5362032 40466924
22
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 79902-63-9 54454
23
Enalaprilat Approved Phase 4,Phase 3,Phase 2,Not Applicable 76420-72-9 6917719
24
Hydroxocobalamin Approved Phase 4,Phase 2,Phase 3,Not Applicable 13422-51-0 11953898 44475014
25
leucovorin Approved Phase 4,Phase 2,Phase 3,Not Applicable 58-05-9 6006 143
26
Phytonadione Approved, Investigational Phase 4,Phase 2,Not Applicable 84-80-0 4812 5284607
27
Paclitaxel Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 33069-62-4 36314
28
Fluvastatin Approved Phase 4,Phase 3,Not Applicable 93957-54-1 1548972
29
Bivalirudin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 128270-60-0 16129704
30
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6 772 46507594
31
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 113775-47-6 68602 5311068
32
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
33
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 28523-86-6 5206
34
Sufentanil Approved, Investigational Phase 4,Not Applicable 56030-54-7 41693
35
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 175805 71273
36
Etomidate Approved Phase 4 33125-97-2 667484 36339
37
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-61-7 60961
38
Ticagrelor Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 274693-27-5 9871419
39
Chitosan Approved Phase 4 9012-76-4 71853
40
Vorapaxar Approved Phase 4,Phase 3,Phase 2 618385-01-6
41
Thrombin Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable
42
Ezetimibe Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 163222-33-1 150311
43
Tirofiban Approved Phase 4,Phase 3,Phase 1 144494-65-5 60947
44
Trimetazidine Approved, Investigational Phase 4,Not Applicable 5011-34-7
45
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3 73590-58-6 4594
46
Pantoprazole Approved Phase 4,Phase 3 102625-70-7 4679
47
Tocopherol Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 1406-66-2 14986
48
Lovastatin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 75330-75-5 53232
49
Cobalt Approved, Experimental Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-48-4 104729
50
Chromium Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-47-3 27668

Interventional clinical trials:

(show top 50) (show all 5962)
# Name Status NCT ID Phase Drugs
1 Sufficient Treatment of Peripheral Intervention by Cilostazol Unknown status NCT00912756 Phase 4 cilostazol
2 Kronos Early Estrogen Prevention Study (KEEPS) Unknown status NCT00154180 Phase 4 Conjugated equine estrogens 0.45 mg/day;Transdermal estradiol, 50 mcg/day;Micronized progesterone, 200 mg/day x 12 d/month;CEE , progesterone, estradiol patch or placebo for each;CEE, progesterone, transdermal patch or the placebo
3 Study to Investigate the Effect of Heart Rate Reduction With Ivabradine on Vascular Elastic Properties and Endothelial Function in Patients With Stable Coronary Heart Disease Unknown status NCT01768585 Phase 4 Ivabradine;Placebo
4 The Low HDL On Six Weeks Statin Therapy (LOW) Study Unknown status NCT00238004 Phase 4 Nicotinic acid
5 Effect of Short Term Atorvastatin Treatment,80mg/Day on Early Regression of Carotid Artery Atherosclerotic Lesions Unknown status NCT00640744 Phase 4 Atorvastatin
6 Fibrosis in Renal Allografts Unknown status NCT00493194 Phase 4 sirolimus;cyclosporine;daclizumab
7 The Elderly ACS II Trial Unknown status NCT01777503 Phase 4 prasugrel;Clopidogrel
8 Testosterone Therapy on Angina Threshold and Atheroma in Patients With Chronic Stable Angina Unknown status NCT00131183 Phase 4 Nebido
9 Intensive Statin Treatment in Acute Ischemic Stroke Patients With INtracranial Atherosclerosis Unknown status NCT02458755 Phase 4 High-dose statin: Atorvastatin 40mg or Rosuvastatin 20mg
10 The Effects of Pravastatin and Rosuvastatin on Coronary Plaques in Patients With Stable Angina Pectoris Unknown status NCT01325818 Phase 4 pravastatin, rosuvastatin
11 Does Rosuvastatin Delay Progression of Atherosclerosis in HIV Unknown status NCT01813357 Phase 4 Rosuvastatin
12 Early Detection of Atherosclerosis: a Randomized Trial in the Primary Prevention of Cardiovascular Diseases. Unknown status NCT00734123 Phase 4 Simvastatin or Atorvastatin;Enalapril;Aspirin or clopidogrel;Rimonabant
13 Homocysteine Lowering and Atherosclerosis Reduction Trial (HART) Unknown status NCT00217178 Phase 4 Vitamins: Folic acid, B6, B12
14 Vitamin K2 and Vessel Calcification in Chronic Kidney Disease Patients Unknown status NCT01101698 Phase 4 Vitamin K2+10μg cholecalciferol;Vitamin D
15 Paclitaxel Eluting Stent or Exercise for Thigh Atherosclerosis Unknown status NCT02033135 Phase 4
16 Efficacy of Self-Expanding Nitinol S.M.A.R.T CONTROL Stent Versus Life Stent For The Atherosclerotic Femoro-Popliteal Arterial Disease Unknown status NCT01653600 Phase 4
17 The Effect of Vitamin A on Atherosclerosis Unknown status NCT01414972 Phase 4 Vitamin A;placebo
18 The Study of the Effects of Vitamin A on Immune System in Patients With Atherosclerosis Unknown status NCT00963222 Phase 4 vitamin A;placebo
19 The Effect of Dates on Plasma Lipids, Oxidative Stress and the Atherogenicity of Serum in Healthy Adults Unknown status NCT00750789 Phase 4
20 Fluvastatin AmelIorates aTHerosclerosis Study Unknown status NCT01681199 Phase 4 Fluvastatin extended release tablet
21 The ABC Trial Does All-Blood Cardioplegia Prevent Blood Transfusion in Cardiac Surgery? A Single Centre Pilot Study Unknown status NCT01623193 Phase 4
22 Different Dosage of Domestic and Imported Clopidogrel on the Platelet Inhibition Ratio in Patients Undergoing PCI Unknown status NCT03006835 Phase 4 Clopidogrel
23 Bivalirudin in Stable Ischemic Heart Disease Patients Undergoing PCI Unknown status NCT02787317 Phase 4 bivalirudin;Heparin
24 The Effect of a Natural Polyphenolic Extract From Pomegrnate (POMX) on the Development of Atherosclerosis in Diabetic Patients Unknown status NCT00470808 Phase 4 POMx
25 Studies of Application of Combined General Anesthesia and Bilateral TPVB in OPCABG Unknown status NCT02727712 Phase 4 Anesthesia drugs during the surgery
26 ATHERO: Advanced Technology Halting Early Re-Stenosis and Occlusion Unknown status NCT00407940 Phase 4
27 Endothelial Dysfunction in Subjects With History of Premature Coronary Artery Disease Unknown status NCT00917527 Phase 4 Atorvastatin
28 Relation Among Shear Stress Distribution, Stent Design, and Subsequent Vessel Healing After Drug-eluting Stent Implantation (SHEAR DES) Unknown status NCT01942044 Phase 4
29 Effects of REnal Denervation for Resistant Hypertension on Exercise Diastolic Function and Regression of Atherosclerosis and the Evaluation of NEW Methods Predicting A successfuL Renal Sympathetic Denervation (RENEWAL-EXERCISE, -REGRESS, and -PREDICT Trial From RENEWAL RDN Registry) Unknown status NCT01918111 Phase 4 adenosine infusion treatment
30 Danshen Dropping Pill for Coronary Heart Disease Heart and Artery Structure and Function Unknown status NCT01825759 Phase 4 danshen dripping pill
31 Intracoronary Stenting and Antithrombotic Regimen: ADjusting Antiplatelet Treatment in PatienTs Based on Platelet Function Testing Unknown status NCT01456364 Phase 4 Ticagrelor;Prasugrel
32 Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis - SAfety & EffectiveneSS of Drug-ElUting Stents & Anti-platelet REgimen Unknown status NCT01267734 Phase 4 Triple anti-platelet therapy (TAT);Double-dose clopidogrel anti-platelet therapy (DDAT)
33 Test of Long-Term Safety and Efficacy of Sirolimus-Permanent-Polymer Eluting Stent (Cypher)- and Sirolimus-Polymer-free Eluting Stents (PPS/PFS) Assessed by Optical Coherence Tomography Unknown status NCT01260558 Phase 4
34 Test Safety and Efficacy of Zotarolimus- and Everolimus-Eluting Stents (ZES/EES) Assessed by Optical Coherence Tomography Unknown status NCT01230723 Phase 4
35 Paclitaxel Eluting Balloon and Conventional Balloon for In-Stent Restenosis of the Superficial Femoral Artery Unknown status NCT01083394 Phase 4
36 Test Efficacy of Biodegradable and Permanent Limus-Eluting Stents Unknown status NCT01068106 Phase 4
37 Efficacy Study of Stenting, Paclitaxel Eluting Balloon or Atherectomy to Treat Peripheral Artery Disease Unknown status NCT00986752 Phase 4
38 Intensive Rosuvastatin Therapy on Cerebral Hemodynamics in Patients With Atherosclerotic Intracranial Arterial Stenosis Unknown status NCT02594800 Phase 4 Rosuvastatin
39 A Multicenter, Therapeutic Used Study to Evaluate the Efficacy and Safety of Pletaal SR Capsule (Cilostazol) in Subjects With Peripheral Arterial Disease Symptom Due to Chronic Occlusive Arterial Disease Unknown status NCT01711333 Phase 4 Pletaal SR capsule
40 Residual Platelet Activity In Advanced Peripheral Artery Disease Unknown status NCT01627431 Phase 4 Acetylsalicylic acid;Clopidogrel
41 Periodontal Therapy in Coronary Artery Patients Unknown status NCT01609725 Phase 4
42 Using 3D Imaging to Optimize Bifurcation Stenting Unknown status NCT02972489 Phase 4
43 Hemostasis Pad Using Chitosan After Invasive Percutaneous Procedures Unknown status NCT02954029 Phase 4
44 Prospective Multicenter Registry of Hybrid Coronary Artery Revascularization Combined With Surgical Bypass and Percutaneous Coronary Intervention Using Everolimus Eluting Metallic Stents Unknown status NCT02894255 Phase 4
45 Influence of Vorapaxar on Thrombin Generation and Coagulability Unknown status NCT02629367 Phase 4 Vorapaxar;Asprin;Clopidogrel
46 Ezetimibe and Atorvastatin Therapy on TCFA Unknown status NCT02588235 Phase 4 Ezetimibe and Atorvastatin;Atorvastatin
47 Safety and Efficacy of Low-dose Ticagrelor in Chinese Patients With Stable Coronary Artery Disease Unknown status NCT02514642 Phase 4 low-dose ticagrelor;Clopidogrel
48 Plasma and Platelet microRNAs in Clopidogrel Low Response Patients Unknown status NCT02447809 Phase 4 Clopidogrel;acetylsalicylic acid (ASA)
49 Efficacy and Safety of Different Dose of Tirofiban in Interventional Treatment of Complex Coronary Artery Disease Unknown status NCT02294994 Phase 4 tirofiban
50 Effect of Cilostazol on Endothelial Progenitor Cells and Endothelial Function in Coronary Artery Disease Unknown status NCT02174939 Phase 4 Cilostazol;Dummy Placebo

Search NIH Clinical Center for Arteriosclerosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: arteriosclerosis

Sources

Genetic Tests for Arteriosclerosis

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Sources

Anatomical Context for Arteriosclerosis

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MalaCards organs/tissues related to Arteriosclerosis:

41
Heart, Endothelial, Kidney, Smooth Muscle, Bone, Testes, T Cells
Sources

Publications for Arteriosclerosis

About this section

Articles related to Arteriosclerosis:

(show top 50) (show all 1407)
# Title Authors Year
1
The differentiation of mesenchymal stem cells to vascular cells regulated by the HMGB1/RAGE axis: its application in cell therapy for transplant arteriosclerosis. ( 29615103 )
2018
2
Pulsatile flow of non-Newtonian blood fluid inside stenosed arteries: Investigating the effects of viscoelastic and elastic walls, arteriosclerosis, and polycythemia diseases. ( 29249336 )
2018
3
Spontaneously occurring intramural coronary arteriosclerosis in regularly slaughtered veal calves and beef cattle: aA screening study about prevalence and histopathological features. ( 29371083 )
2018
4
Graft protective effect and induction of CD4<sup>+</sup>Foxp3<sup>+</sup> cell by Thrombomodulin on allograft arteriosclerosis in mice. ( 29783997 )
2018
5
Clipping treatment of posterior communicating artery aneurysms associated with arteriosclerosis and calcification: A single center study of 136 cases. ( 29434749 )
2018
6
MicroRNA-31 promotes arterial smooth muscle cell proliferation and migration by targeting mitofusin-2 in arteriosclerosis obliterans of the lower extremitie. ( 29403548 )
2018
7
Retinal vessel narrowing: an early predictor of future arteriosclerosis? ( 29384985 )
2018
8
Arteriosclerosis Is a Major Predictor of Small Bowel Vascular Lesions. ( 29372478 )
2018
9
Increased plasma olfactomedin 2 after interventional therapy is a predictor for restenosis in lower extremity arteriosclerosis obliterans patients. ( 29553861 )
2018
10
Pronounced Coronary Arteriosclerosis in Cirrhosis: Influence on Cardiac Function and Survival? ( 29516327 )
2018
11
Night-time activation of the intrarenal renin-angiotensin system due to nocturnal hypertension is associated with renal arteriosclerosis in normotensive IgA nephropathy patients. ( 29507351 )
2018
12
Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study. ( 29382349 )
2018
13
Accelerated atheromatosis and arteriosclerosis in primary systemic vasculitides: current evidence and future perspectives. ( 29040156 )
2018
14
Role of Resident Stem Cells in Vessel Formation and Arteriosclerosis. ( 29798903 )
2018
15
Response by Daugherty et al to Letter Regarding Article, &amp;quot;Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies: A Statement From the <i>Arteriosclerosis, Thrombosis, and Vascular Biology</i> Council&amp;quot;. ( 29793996 )
2018
16
Arteriosclerosis, Thrombosis, and Vascular Biology. ( 29282242 )
2018
17
Assessment of Subtle Changes in Diabetes-Associated Arteriosclerosis using Photoplethysmographic Pulse Wave from Index Finger. ( 29368039 )
2018
18
Arteriosclerosis in Brazil. Findings from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). ( 29791607 )
2018
19
Letter by Ramirez and Hibbert Regarding Article, &amp;quot;Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies: A Statement From the <i>Arteriosclerosis, Thrombosis, and Vascular Biology</i> Council&amp;quot;. ( 29793995 )
2018
20
Circulating odd-chain saturated fatty acids were associated with arteriosclerosis among patients with diabetes, dyslipidemia, or hypertension in Sri Lanka but not Japan. ( 29540275 )
2018
21
Consensus document of the Spanish Society of Arteriosclerosis (SEA) for the prevention and treatment of cardiovascular disease in type 2 diabetes mellitus. ( 30053980 )
2018
22
Outcomes in Patients with Critical Limb Ischemia due to Arteriosclerosis Obliterans Who Did Not Undergo Arterial Reconstruction. ( 30101855 )
2018
23
Relationship between ABCA1 gene polymorphism and lacunar infarction combined with arteriosclerosis in patients. ( 30112062 )
2018
24
Prevalence, Incidence, and Contributors of Subclinical Atheromatosis, Arteriosclerosis, and Arterial Hypertrophy in HIV-Infected Individuals: A Single-Center, 3-Year Prospective Study. ( 30235944 )
2018
25
PI3Kγ promotes vascular smooth muscle cell phenotypic modulation and transplant arteriosclerosis via a SOX9-dependent mechanism. ( 30241919 )
2018
26
FAL1 regulates endothelial cell proliferation in diabetic arteriosclerosis through PTEN/AKT pathway. ( 30338819 )
2018
27
Usefulness of Carotid Arterial Strain Values for Evaluating the Arteriosclerosis. ( 30344204 )
2018
28
Intravenous hydrogen sulfide does not induce neuroprotection after aortic balloon occlusion-induced spinal cord ischemia/reperfusion injury in a human-like porcine model of ubiquitous arteriosclerosis. ( 30357563 )
2018
29
HOXA11-AS regulates diabetic arteriosclerosis-related inflammation via PI3K/AKT pathway. ( 30402857 )
2018
30
Cardiac Allograft Vasculopathy　- Heart Transplantation Provides Insights Into Pathogenesis and Treatment of Arteriosclerosis. ( 30404978 )
2018
31
AIP1 suppresses transplant arteriosclerosis through inhibition of vascular smooth muscle cell inflammatory response to IFNγ. ( 30471213 )
2018
32
Association of renal arteriosclerosis and hypertension with renal and cardiovascular outcomes in Japanese type 2 diabetic patients with diabetic nephropathy. ( 30516352 )
2018
33
Subclinical parameters of arterial stiffness and arteriosclerosis correlate with QRISK3 in systemic lupus erythematosus. ( 30517121 )
2018
34
Association of arteriosclerosis and/or atherosclerosis with hypertensive target organ damage in the community-dwelling elderly Chinese: the Northern Shanghai Study. ( 28652715 )
2017
35
Efficacy of continuous positive airway pressure treatment in treating obstructive sleep apnea hypopnea syndrome associated with carotid arteriosclerosis. ( 29285176 )
2017
36
Difference in bilateral digital volume pulse as a novel non-invasive approach to assessing arteriosclerosis in aged and diabetic subjects: A preliminary study. ( 28467197 )
2017
37
Intima-Media Thickness in the Carotid and Femoral Arteries for Detection of Arteriosclerosis in Human Immunodeficiency Virus-Positive Individuals. ( 28146208 )
2017
38
The Association between Polymorphism of CARD8 rs2043211 and Susceptibility to Arteriosclerosis Obliterans in Chinese Han Male Population. ( 28135700 )
2017
39
The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis. ( 28569748 )
2017
40
National Dyslipidemia Registry of the Spanish Arteriosclerosis Society: Current status. ( 29102473 )
2017
41
Effect of sirolimus on arteriosclerosis induced by advanced glycation end products via inhibition of the ILK/mTOR pathway in kidney transplantation recipients. ( 28669853 )
2017
42
Sarcopenia and physical function are associated with inflammation and arteriosclerosis in community-dwelling people: The Yakumo study. ( 28741974 )
2017
43
Consensus document on the management of the atherogenic dyslipidaemia of the Spanish Society of Arteriosclerosis. ( 28185675 )
2017
44
Commonalities Between Vasculature and Bone: An Osseocentric View of Arteriosclerosis. ( 28115412 )
2017
45
Arteriosclerosis, Thrombosis, and Vascular Biology. ( 28062452 )
2017
46
WITHDRAWN: What exactly, regression of atherosclerosis or foreign body reaction with hyaline arteriosclerosis, drives transient scaffolding of coronary arteries? A pooled analysis of observational ABSORB studies with a serial multimodality imaging substudy of ABSORB cohort B1 trial. ( 28629625 )
2017
47
Diffuse Carotid Arteriosclerosis and Stroke in a Patient With Schimke Immuno-osseous Dysplasia. ( 28412018 )
2017
48
Decalogue of the Spanish Society of Arteriosclerosis to reduce therapeutic inertia. ( 28844490 )
2017
49
Role of TLR4 and miR-155 in peripheral blood mononuclear cell-mediated inflammatory reaction in coronary slow flow and coronary arteriosclerosis patients. ( 28407320 )
2017
50
Potential Effects of Desalinated Seawater on Arteriosclerosis in Rats. ( 29122097 )
2017
Sources

Variations for Arteriosclerosis

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ClinVar genetic disease variations for Arteriosclerosis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 HS3ST1 NM_005114.2(HS3ST1): c.-108-6848A> G single nucleotide variant risk factor rs16881446 GRCh37 Chromosome 4, 11408585: 11408585
2 HS3ST1 NM_005114.2(HS3ST1): c.-108-6848A> G single nucleotide variant risk factor rs16881446 GRCh38 Chromosome 4, 11406961: 11406961
Sources

Expression for Arteriosclerosis

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Search GEO for disease gene expression data for Arteriosclerosis.
Sources

Pathways for Arteriosclerosis

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Pathways related to Arteriosclerosis according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Degradation of the extracellular matrix 66
Show member pathways
 12.58 ELN ICAM1 SERPINE1 SPP1 VCAM1
2
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 12.05 CCL2 ELN ICAM1 SPP1 VCAM1
3
Statin Pathway 1
Show member pathways
 11.81 APOA1 APOB APOE HMGCR
4
Fluid shear stress and atherosclerosis 37
11.8 CCL2 EDN1 HMOX1 ICAM1 VCAM1
5
Binding and Uptake of Ligands by Scavenger Receptors 66
Show member pathways
 11.76 APOA1 APOB APOE
6
Interleukin-4 and 13 signaling 66
11.76 CCL2 HMOX1 ICAM1 VCAM1
7
HIF-1 signaling pathway 37
11.73 EDN1 HMOX1 SERPINE1
8
TNF signaling pathway 37
11.71 CCL2 EDN1 ICAM1 VCAM1
9
PPAR signaling pathway 37
11.58 ADIPOQ APOA1 PPARG
10
AGE-RAGE signaling pathway in diabetic complications 37
11.55 CCL2 EDN1 ICAM1 SERPINE1 VCAM1
11
HIF-1-alpha transcription factor network 1
11.5 EDN1 HMOX1 SERPINE1
12
Selenium Micronutrient Network 1
Show member pathways
 11.5 APOA1 APOB APOE CCL2 CRP ICAM1
13
Malaria 37
11.36 CCL2 ICAM1 VCAM1
14
African trypanosomiasis 37
11.2 APOA1 ICAM1 VCAM1
15
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.16 CCL2 HMOX1 MGP
16
Lung fibrosis 1
11.15 CCL2 EDN1 ELN HMOX1 SPP1
17
LDL Oxidation in Atherogenesis 64
10.7 CCL2 ICAM1 VCAM1
Sources

GO Terms for Arteriosclerosis

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Cellular components related to Arteriosclerosis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 early endosome GO:0005769 9.89 APOA1 APOB APOE HSPD1 VCAM1
2 endoplasmic reticulum lumen GO:0005788 9.85 APOA1 APOB APOE SPP1
3 high-density lipoprotein particle GO:0034364 9.63 APOA1 APOE PON1
4 very-low-density lipoprotein particle GO:0034361 9.61 APOA1 APOB APOE
5 endocytic vesicle lumen GO:0071682 9.58 APOA1 APOB APOE
6 low-density lipoprotein particle GO:0034362 9.54 APOA1 APOB APOE
7 spherical high-density lipoprotein particle GO:0034366 9.52 APOA1 PON1
8 discoidal high-density lipoprotein particle GO:0034365 9.51 APOA1 APOE
9 chylomicron GO:0042627 9.5 APOA1 APOB APOE
10 collagen-containing extracellular matrix GO:0062023 9.5 ADIPOQ APOA1 APOE ELN ICAM1 MGP
11 extracellular space GO:0005615 9.47 ADIPOQ APOA1 APOB APOE CCL2 CRP
12 intermediate-density lipoprotein particle GO:0034363 9.33 APOA1 APOB APOE
13 extracellular exosome GO:0070062 10.18 APOA1 APOB APOE HSPD1 ICAM1 MGP
14 extracellular region GO:0005576 10.03 ADIPOQ APOA1 APOB APOE CCL2 CRP
15 intracellular membrane-bounded organelle GO:0043231 10.01 APOB HMGCR HMOX1 HSPD1 PON1 PPARG

Biological processes related to Arteriosclerosis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.99 APOA1 APOB APOE SPP1
2 negative regulation of neuron apoptotic process GO:0043524 9.93 APOE CCL2 HMOX1 HSPD1
3 extracellular matrix organization GO:0030198 9.93 ELN ICAM1 SERPINE1 SPP1 VCAM1
4 response to drug GO:0042493 9.91 ADIPOQ APOA1 EDN1 HSPD1 ICAM1 PPARG
5 negative regulation of inflammatory response GO:0050728 9.9 ADIPOQ APOA1 APOE
6 cellular response to interferon-gamma GO:0071346 9.9 CCL2 EDN1 ICAM1
7 steroid metabolic process GO:0008202 9.9 APOA1 APOB APOE HMGCR
8 cholesterol homeostasis GO:0042632 9.89 APOA1 APOB APOE
9 regulation of lipid metabolic process GO:0019216 9.89 APOA1 HMGCR PPARG
10 response to ethanol GO:0045471 9.89 ADIPOQ HMGCR ICAM1 VCAM1
11 cellular response to interleukin-1 GO:0071347 9.88 CCL2 EDN1 ICAM1
12 response to lipopolysaccharide GO:0032496 9.88 APOB EDN1 HSPD1 ICAM1 VCAM1
13 regulation of blood pressure GO:0008217 9.86 EDN1 HMOX1 PPARG
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.85 EDN1 HMGCR HMOX1
15 retinoid metabolic process GO:0001523 9.85 APOA1 APOB APOE
16 response to organic substance GO:0010033 9.85 APOB HSPD1 PPARG SPP1
17 response to activity GO:0014823 9.83 ADIPOQ EDN1 HSPD1
18 cholesterol biosynthetic process GO:0006695 9.82 APOA1 APOE HMGCR
19 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.82 ADIPOQ HMOX1 PPARG
20 response to nicotine GO:0035094 9.81 EDN1 HMOX1 VCAM1
21 negative regulation of MAP kinase activity GO:0043407 9.81 ADIPOQ APOE HMGCR
22 response to estrogen GO:0043627 9.8 APOA1 HMOX1 HSPD1 PPARG
23 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.79 HMOX1 ICAM1 SERPINE1
24 cellular response to tumor necrosis factor GO:0071356 9.77 APOB CCL2 EDN1 ICAM1 VCAM1
25 triglyceride catabolic process GO:0019433 9.76 APOA1 APOB APOE
26 cholesterol efflux GO:0033344 9.75 APOA1 APOB APOE
27 lipoprotein metabolic process GO:0042157 9.74 APOA1 APOB APOE
28 fatty acid oxidation GO:0019395 9.73 ADIPOQ PPARG
29 low-density lipoprotein particle clearance GO:0034383 9.73 ADIPOQ APOB HMOX1
30 long-chain fatty acid transport GO:0015909 9.72 APOE PPARG
31 low-density lipoprotein particle remodeling GO:0034374 9.72 APOB APOE
32 negative regulation of wound healing GO:0061045 9.72 HMGCR SERPINE1
33 high-density lipoprotein particle assembly GO:0034380 9.71 APOA1 APOE
34 phospholipid efflux GO:0033700 9.71 APOA1 APOE
35 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.71 ADIPOQ APOA1
36 negative regulation of hormone secretion GO:0046888 9.7 ADIPOQ EDN1
37 high-density lipoprotein particle clearance GO:0034384 9.7 APOA1 APOE
38 negative regulation of blood vessel diameter GO:0097756 9.7 CRP HMGCR
39 positive regulation of cholesterol esterification GO:0010873 9.7 APOA1 APOE
40 negative regulation of blood coagulation GO:0030195 9.7 APOE EDN1 SERPINE1
41 very-low-density lipoprotein particle remodeling GO:0034372 9.69 APOA1 APOE
42 positive regulation of cholesterol efflux GO:0010875 9.69 ADIPOQ APOE PON1
43 chylomicron remnant clearance GO:0034382 9.68 APOB APOE
44 regulation of Cdc42 protein signal transduction GO:0032489 9.68 APOA1 APOE
45 regulation of cholesterol transport GO:0032374 9.68 APOA1 APOE
46 negative regulation of cellular protein metabolic process GO:0032269 9.67 APOE EDN1
47 very-low-density lipoprotein particle clearance GO:0034447 9.66 APOB APOE
48 membrane to membrane docking GO:0022614 9.66 ICAM1 VCAM1
49 adhesion of symbiont to host GO:0044406 9.65 HSPD1 ICAM1
50 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.63 ADIPOQ CRP PPARG

Molecular functions related to Arteriosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex binding GO:0044877 9.78 APOE COG2 HSPD1 ICAM1
2 cytokine activity GO:0005125 9.73 ADIPOQ CCL2 EDN1 SPP1
3 high-density lipoprotein particle binding GO:0008035 9.46 APOA1 HSPD1
4 phospholipid binding GO:0005543 9.46 APOA1 APOB APOE PON1
5 lipid transporter activity GO:0005319 9.43 APOA1 APOB APOE
6 lipoprotein particle binding GO:0071813 9.37 APOA1 APOE
7 phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 9.32 APOA1 APOE
8 low-density lipoprotein particle receptor binding GO:0050750 9.13 APOB APOE CRP
9 cholesterol transporter activity GO:0017127 8.8 APOA1 APOB APOE
10 protein binding GO:0005515 10.33 ADIPOQ APOA1 APOB APOE CCL2 COG2
Sources

Sources for Arteriosclerosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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