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Arteritic Anterior Ischemic Optic Neuropathy

Categories: Eye diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Arteritic Anterior Ischemic Optic Neuropathy

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MalaCards integrated aliases for Arteritic Anterior Ischemic Optic Neuropathy:

Name: Arteritic Anterior Ischemic Optic Neuropathy 12 15

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Eye diseases
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Disease Ontology 12 DOID:0050863
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Summaries for Arteritic Anterior Ischemic Optic Neuropathy

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Disease Ontology : 12 An anterior ischemic optic neuropathy that is characterized by near-complete vision loss caused by damage to the medium-sized blood vessels supplying the optic nerves following temporal arteritis.

MalaCards based summary : Arteritic Anterior Ischemic Optic Neuropathy is related to nonarteritic anterior ischemic optic neuropathy and branch retinal artery occlusion. An important gene associated with Arteritic Anterior Ischemic Optic Neuropathy is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Formation of Fibrin Clot (Clotting Cascade). The drugs Dopamine and Levodopa have been mentioned in the context of this disorder. Affiliated tissues include eye, heart and neutrophil, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Arteritic Anterior Ischemic Optic Neuropathy

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Diseases related to Arteritic Anterior Ischemic Optic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)
# Related Disease Score Top Affiliating Genes
1 nonarteritic anterior ischemic optic neuropathy 32.7 MTHFR GP1BA F5 F2 ACE
2 branch retinal artery occlusion 30.9 MTHFR F2
3 papilledema 30.3 F2 ACE
4 retinal vascular disease 30.2 MTHFR ACE
5 thrombophilia due to activated protein c resistance 30.0 MTHFR F5 F2
6 retinal vascular occlusion 30.0 MTHFR F5 F2
7 central retinal vein occlusion 30.0 MTHFR F5 F2
8 protein s deficiency 30.0 MTHFR F5 F2
9 antiphospholipid syndrome 30.0 MTHFR F5 F2
10 thrombophilia 29.9 MTHFR ITGB3 F5 F2
11 retinal artery occlusion 29.7 MTHFR F5 F2 ACE
12 retinal vein occlusion 29.5 MTHFR F5 F2 ACE
13 thrombocytopenia 29.5 ITGB3 GP1BA F5 F2
14 stroke, ischemic 28.9 MTHFR GP1BA F5 F2 ACE
15 vascular disease 28.8 MTHFR ITGB3 GP1BA F5 F2 ACE
16 cerebrovascular disease 28.6 MTHFR ITGB3 GP1BA F5 F2 ACE
17 optic nerve disease 11.3
18 neuropathy 11.3
19 impotence 10.6
20 temporal arteritis 10.5
21 yemenite deaf-blind hypopigmentation syndrome 10.5
22 intraocular pressure quantitative trait locus 10.5
23 sleep apnea 10.5
24 open-angle glaucoma 10.5
25 vasculitis 10.5
26 posttransplant acute limbic encephalitis 10.5
27 glaucoma, primary open angle 10.4
28 3-methylglutaconic aciduria, type iii 10.4
29 leber optic atrophy 10.4
30 microvascular complications of diabetes 5 10.4
31 hydrops, lactic acidosis, and sideroblastic anemia 10.4
32 ischemic neuropathy 10.4
33 retinal ischemia 10.4
34 lipid metabolism disorder 10.4
35 compartment syndrome 10.4
36 cataract 10.4
37 hereditary optic neuropathy 10.4
38 fetal and neonatal alloimmune thrombocytopenia 10.2 ITGB3 GP1BA
39 autosomal dominant macrothrombocytopenia 10.2 ITGB3 GP1BA
40 apnea, obstructive sleep 10.2
41 hypercholesterolemia, familial, 1 10.2
42 exfoliation syndrome 10.2
43 strabismus 10.2
44 pseudoxanthoma elasticum 10.2
45 angioid streaks 10.2
46 androgenic alopecia 10.2
47 atrial fibrillation 10.2
48 central retinal artery occlusion 10.2
49 thrombocytosis 10.2
50 arteriosclerosis 10.2

Graphical network of the top 20 diseases related to Arteritic Anterior Ischemic Optic Neuropathy:



Diseases related to Arteritic Anterior Ischemic Optic Neuropathy
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Symptoms & Phenotypes for Arteritic Anterior Ischemic Optic Neuropathy

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GenomeRNAi Phenotypes related to Arteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

26 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.66 ATOH7
2 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.66 F2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.66 ATOH7
4 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.66 F2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.66 F2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.66 F2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.66 F2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-173 9.66 MTHFR
9 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.66 F2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.66 MTHFR
11 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.66 ATOH7
12 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.66 ATOH7
13 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.66 MTHFR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.66 ATOH7 F2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.66 MTHFR
16 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.66 MTHFR
17 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.66 MTHFR
18 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.66 MTHFR
19 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.66 ATOH7 F2 MTHFR
20 Increased shRNA abundance GR00327-A 9.13 F5 ITGB3 MTHFR

MGI Mouse Phenotypes related to Arteritic Anterior Ischemic Optic Neuropathy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.02 ACE ATOH7 F2 ITGB3 MTHFR
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Drugs & Therapeutics for Arteritic Anterior Ischemic Optic Neuropathy

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Drugs for Arteritic Anterior Ischemic Optic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Levodopa Approved Phase 4 59-92-7 6047
3
Carbidopa Approved Phase 4 28860-95-9 34359
4
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
5
Choline Approved, Nutraceutical Phase 4 62-49-7 305
6 Neurotransmitter Agents Phase 4
7 Dopamine Agents Phase 4
8 Aromatic Amino Acid Decarboxylase Inhibitors Phase 4
9 Antiparkinson Agents Phase 4
10 Immunologic Factors Phase 4
11 Carbidopa, levodopa drug combination Phase 4
12 Adjuvants, Immunologic Phase 4
13 Dopamine agonists Phase 4
14 Nootropic Agents Phase 4
15 Cytidine Diphosphate Choline Phase 4
16 Vardenafil Dihydrochloride Phase 4
17 Phosphodiesterase 5 Inhibitors Phase 4
18 Sildenafil Citrate Phase 4 171599-83-0
19 Phosphodiesterase Inhibitors Phase 4
20
Bevacizumab Approved, Investigational Phase 2 216974-75-3
21
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
22
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
23
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
24
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
25 Prednisolone acetate Approved, Vet_approved Phase 2 52-21-1
26
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
27 Angiogenesis Inhibitors Phase 2
28 Antineoplastic Agents, Immunological Phase 2
29 Neuroprotective Agents Phase 2
30 Methylprednisolone Acetate Phase 2
31 Antiemetics Phase 2
32 Gastrointestinal Agents Phase 2
33 Hormone Antagonists Phase 2
34 Anti-Inflammatory Agents Phase 2
35 Autonomic Agents Phase 2
36 Protective Agents Phase 2
37 Antineoplastic Agents, Hormonal Phase 2
38 glucocorticoids Phase 2
39 Hormones Phase 2
40 Epoetin alfa Phase 2 113427-24-0
41 Hematinics Phase 2

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy Completed NCT00432393 Phase 4 levodopa-carbidopa
2 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) : Pattern Electroretinography Study Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
3 Prospective Case Crossover Study to Assess Whether PDE5 Inhibitor Exposure in Men Increases the Risk for the Development of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Terminated NCT00867815 Phase 4 Diagnostic procedures
4 The Effect of High Dose Steroid and Normobaric Oxygen Therapy on Recent Onset Non-arteritic Anterior Ischemic Optic Neuropathy(NAION); a Randomized Clinical Trial Unknown status NCT02439866 Phase 3 placebo;Intravenous methylprednisolone;normobaric oxygen with face mask
5 A Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 Delivered By Single or Multi-Dose Intravitreal Injection(s) to Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Terminated NCT02341560 Phase 2, Phase 3 QPI-1007 Injection - 1.5 mg;QPI-1007 Injection - 3.0 mg
6 Intravitreal Bevacizumab for Treatment of the Second Eye With Non-Arteritic Ischemic Optic Neuropathy Unknown status NCT00813059 Phase 2 Intra-vitreal injection of bevacizumab (1.25mg/0.05ml)
7 Phase II Safety Assessment of Intravitreal Injection of Mesenchymal Stem Cells for Acute Non Arteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT03173638 Phase 2
8 Scientific Title: Efficacy of Oral Prednisolone and Erythropoietin Injection in Treatment of Acute Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT03715881 Phase 2 Oral prednisolone administration 50 mg;Intravenous Erythropoietin injection
9 A Phase I Open-Label, Dose Escalation Trial of QPI-1007 Delivered by a Single Intravitreal Injection to Patients With Optic Nerve Atrophy (Stratum I) and Acute Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) (Stratum II) Completed NCT01064505 Phase 1 QPI-1007 at various doses
10 Can Urgent Reduction of Intraocular Pressure With Ophthalmic Timolol Improve Recovery From Non-arteritic Anterior Ischemic Optic Neuropathy (NAION): a Randomized Study. Withdrawn NCT01607671 Phase 1 Timolol maleate
11 The Detection and Epidemiology of NAION in a Commercially Insured Population in the United States. Completed NCT01260324
12 Visual Field Defects in Non-Arteritic Anterior Ischemic Optic Neuropathy: Effect of Vision Restoration Therapy (VRT) Completed NCT00140491
13 Evaluation of the Effectiveness and Safety of Transcorneal Electrical Stimulation to Improve Visual Function After Ocular Trauma Completed NCT02019927
14 Retinal Neuro-vascular Coupling in Patients With Non-arteritic Anterior Ischemic Optic Neuropathy Recruiting NCT03401892

Search NIH Clinical Center for Arteritic Anterior Ischemic Optic Neuropathy

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Genetic Tests for Arteritic Anterior Ischemic Optic Neuropathy

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Anatomical Context for Arteritic Anterior Ischemic Optic Neuropathy

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MalaCards organs/tissues related to Arteritic Anterior Ischemic Optic Neuropathy:

40
Eye, Heart, Neutrophil, Retina, Brain, Endothelial, Spinal Cord
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Publications for Arteritic Anterior Ischemic Optic Neuropathy

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Articles related to Arteritic Anterior Ischemic Optic Neuropathy:

(show top 50) (show all 231)
# Title Authors PMID Year
1
Prospective analysis of macular and optic disc changes after non-arteritic anterior ischemic optic neuropathy. 61
31706462 2020
2
Assessment of peripapillary vessel density in acute non-arteritic anterior ischemic optic neuropathy. 61
31960199 2020
3
A neuroglia-based interpretation of glaucomatous neuroretinal rim thinning in the optic nerve head. 61
31982595 2020
4
Acute changes in ganglion cell layer thickness in ischemic optic neuropathy compared to optic neuritis using optical coherence tomography. 61
31956579 2020
5
Neuro-Ophthalmologic Complications of Giant Cell Arteritis: Diagnosis and Treatment. 61
31847038 2019
6
Non artheritic bilateral anterior ischaemic optic neuropathy (NAION) as devastating complication following Total Hip Arthroplasty: a case report. 61
31910190 2019
7
Unraveling the Enigma of Nonarteritic Anterior Ischemic Optic Neuropathy. 61
31790002 2019
8
Steroids in the treatment of nonarteritic anterior ischemic optic neuropathy: A PRISMA-compliant meta-analysis. 61
31725628 2019
9
Non-arteritic anterior ischemic optic neuropathy with Cilioretinal artery occlusion: a case report. 61
31726996 2019
10
Acute Unilateral Anterior Ischemic Optic Neuropathy Secondary to Optic Nerve Head Drusen: Report of a Rare Coexistence. 61
31741680 2019
11
[Non-arteritic Anterior Ischaemic Optic Neuropathy: Pathogenesis and Therapeutic Approaches]. 61
31711249 2019
12
[Value of Optical Coherence Tomography Angiography in Neuroophthalmology]. 61
31509884 2019
13
Choroidal Vascular Changes in Arteritic and Nonarteritic Anterior Ischemic Optic Neuropathy. 61
30954470 2019
14
[Optic nerve morphology and vessel density in eyes with different phases of non-arteritic anterior ischemic optic neuropathy]. 61
31495153 2019
15
Systemic oxidative stress in non-arteritic anterior ischemic optic neuropathy. 61
30833666 2019
16
Arteritic Anterior Ischemic Optic Neuropathy Associated with Giant-Cell Arteritis in Korean Patients: A Retrospective Single-Center Analysis and Review of the Literature. 61
31286712 2019
17
Two Cases of Segmental Disc Oedema and Normal Visual Acuity in Giant Cell Arteritis. 61
31312246 2019
18
Ischemic optic neuropathy in robotic-assisted gynaecologic surgery: A case report. 61
30520549 2019
19
[Pay attention to the quality of evidence research for appropriate evaluation of the treatment trail of the non-arteritic anterior ischemic optic neuropathy]. 61
30841682 2019
20
Abnormal spontaneous brain activity in patients with non-arteritic anterior ischemic optic neuropathy detected using functional magnetic resonance imaging. 61
30855358 2019
21
Lamina cribrosa position and Bruch's membrane opening differences between anterior ischemic optic neuropathy and open-angle glaucoma. 61
29911429 2019
22
[Vessel density and structure in the macular region of non-arteritic anterior ischemic optic neuropathy patients]. 61
30841686 2019
23
Visual Impairment After Haemodialysis. 61
30723524 2019
24
Characterization of retinal microvasculature in acute non-arteritic anterior ischemic optic neuropathy using the retinal functional imager: a prospective case series. 61
30675495 2019
25
Disc Configuration as a Risk and Prognostic Factor in NAION: The Impact of Cup to Disc Ratio, Disc Diameter, and Crowding Index. 61
31162995 2019
26
Giant cell arteritis related arteritic anterior ischemic optic neuropathy: Clinico-pathological correlation. 61
30574925 2019
27
Bilateral simultaneous non-arteritic anterior ischemic optic neuropathy with occlusion of unilateral cilioretinal artery: A case report. 61
31909390 2019
28
Non-Arteritic Anterior Ischemic Optic Neuropathy in Pilots. 61
30352654 2018
29
Three-Dimensional High-Resolution Black-Blood Magnetic Resonance Imaging for Detection of Arteritic Anterior Ischemic Optic Neuropathy in Patients With Giant Cell Arteritis. 61
30095558 2018
30
Could Platelet Indices and Neutrophil to Lymphocyte Ratio Be New Biomarkers for Differentiation of Arteritic Anterior Ischemic Neuropathy from Non-Arteritic Type? 61
30258474 2018
31
Incidence and Mimickers of Acute Idiopathic Optic Neuritis: Analysis of 291 Consecutive Patients from Southern Finland. 61
30040514 2018
32
Acute visual loss and optic disc edema followed by optic atrophy in two cases with deeply buried optic disc drusen: a mimicker of atypical optic neuritis. 61
30367617 2018
33
Giant Cell Arteritis Associated Arteritic Anterior Ischemic Optic Neuropathy: Sudden Vision Loss on the Contralateral Side of Headache. 61
30198237 2018
34
The polymorphisms of ATOH 7, ET-1 and ACE in non-arteritic anterior ischemic optic neuropathy. 61
29792847 2018
35
The Association Between Phosphodiesterase Type 5 Inhibitor Use and Risk of Non-Arteritic Anterior Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis. 61
29884471 2018
36
Non-arteritic anterior ischemic optic neuropathy - Case report. 61
30505994 2018
37
Critical flicker fusion frequency in demyelinating and ischemic optic neuropathies. 61
28527029 2018
38
Prognosis and monitoring of giant cell arteritis and associated complications. 61
29676201 2018
39
Anomalous coagulation factors in non-arteritic anterior ischemic optic neuropathy with central retinal vein occlusion: A case report. 61
29642215 2018
40
Quantitative analysis of optical coherence tomographic angiography (OCT-A) in patients with non-arteritic anterior ischemic optic neuropathy (NAION) corresponds to visual function. 61
29953490 2018
41
Optical coherence tomography angiography at the acute phase of optic disc edema. 61
29977949 2018
42
Pattern of peripapillary capillary density loss in ischemic optic neuropathy compared to that in primary open-angle glaucoma. 61
29320503 2018
43
Relative Frequencies of Arteritic and Nonarteritic Anterior Ischemic Optic Neuropathy in an Arab Population. 61
28099197 2017
44
Optical coherence tomography angiography in acute arteritic and non-arteritic anterior ischemic optic neuropathy. 61
28861697 2017
45
Tocilizumab for giant cell arteritis with corticosteroid-resistant progressive anterior ischemic optic neuropathy. 61
28499892 2017
46
Bilateral Arteritic Anterior Ischemic Optic Neuropathy Associated with Giant Cell Arteritis in Korea. 61
28994270 2017
47
Carotid artery intimal medial thickness and carotid artery plaques in hypertensive patients with non-arteritic anterior ischaemic optic neuropathy. 61
28733725 2017
48
[Bilateral acute arteritic anterior ischemic optic neuropathy during chronic steroid therapy]. 61
28801036 2017
49
Visual outcome following bilateral non-arteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis. 61
28836961 2017
50
Crowded optic nerve head evaluation with optical coherence tomography in anterior ischemic optic neuropathy. 61
28387764 2017
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Variations for Arteritic Anterior Ischemic Optic Neuropathy

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Expression for Arteritic Anterior Ischemic Optic Neuropathy

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Search GEO for disease gene expression data for Arteritic Anterior Ischemic Optic Neuropathy.
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Pathways for Arteritic Anterior Ischemic Optic Neuropathy

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Pathways related to Arteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 65
Show member pathways
 12.7 ITGB3 GP1BA F5 F2
2
Formation of Fibrin Clot (Clotting Cascade) 65
Show member pathways
 11.53 GP1BA F5 F2
3
Platelet activation 36
11.23 ITGB3 GP1BA F2
4
Platelet Aggregation Inhibitor Pathway, Pharmacodynamics 60
10.96 ITGB3 F2
5
Integrin alphaIIb beta3 signaling 65
Show member pathways
 10.79 ITGB3 GP1BA F2
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GO Terms for Arteritic Anterior Ischemic Optic Neuropathy

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Biological processes related to Arteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet aggregation GO:0070527 9.4 ITGB3 GP1BA
2 fibrinolysis GO:0042730 9.37 GP1BA F2
3 platelet activation GO:0030168 9.33 ITGB3 GP1BA F2
4 blood coagulation, intrinsic pathway GO:0007597 9.32 GP1BA F2
5 regulation of blood coagulation GO:0030193 9.26 GP1BA F2
6 hemostasis GO:0007599 9.13 GP1BA F5 F2
7 blood coagulation GO:0007596 8.92 ITGB3 GP1BA F5 F2
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Sources for Arteritic Anterior Ischemic Optic Neuropathy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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