MCID: ART110
MIFTS: 35

Arteritic Anterior Ischemic Optic Neuropathy

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Arteritic Anterior Ischemic Optic Neuropathy

MalaCards integrated aliases for Arteritic Anterior Ischemic Optic Neuropathy:

Name: Arteritic Anterior Ischemic Optic Neuropathy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050863

Summaries for Arteritic Anterior Ischemic Optic Neuropathy

Disease Ontology : 12 An anterior ischemic optic neuropathy that is characterized by near-complete vision loss caused by damage to the medium-sized blood vessels supplying the optic nerves following temporal arteritis.

MalaCards based summary : Arteritic Anterior Ischemic Optic Neuropathy is related to nonarteritic anterior ischemic optic neuropathy and open-angle glaucoma. An important gene associated with Arteritic Anterior Ischemic Optic Neuropathy is ITGB3 (Integrin Subunit Beta 3), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. Affiliated tissues include heart, eye and neutrophil, and related phenotypes are cardiovascular system and liver/biliary system

Related Diseases for Arteritic Anterior Ischemic Optic Neuropathy

Diseases related to Arteritic Anterior Ischemic Optic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
# Related Disease Score Top Affiliating Genes
1 nonarteritic anterior ischemic optic neuropathy 33.5 ACE F2 F5 GP1BA MTHFR NOS3
2 open-angle glaucoma 30.8 ATOH7 GSTM1 GSTT1
3 central retinal vein occlusion 30.7 F2 F5 MTHFR
4 retinal vein occlusion 30.7 F2 F5 MTHFR
5 thrombophilia 30.6 F2 F5 MTHFR
6 antiphospholipid syndrome 30.6 F2 F5 MTHFR
7 branch retinal artery occlusion 30.6 F2 FANCG MTHFR
8 sleep apnea 30.4 ACE CRP NOS3
9 retinal artery occlusion 30.4 ACE F2 F5 MTHFR
10 retinal vascular occlusion 30.3 F2 F5 FANCG MTHFR
11 ischemic optic neuropathy 30.2 ACE F2 F5 GP1BA GSTM1 GSTT1
12 optic nerve disease 11.2
13 neuropathy 11.2
14 fetal and neonatal alloimmune thrombocytopenia 10.5 GP1BA ITGB3
15 hemifacial spasm 10.4 MTHFR NOS3
16 hearing loss, noise-induced 10.4 GSTM1 GSTT1
17 inferior vena cava interruption 10.4 F5 MTHFR
18 sister chromatid exchange, frequency of 10.4 GSTM1 GSTT1
19 amaurosis fugax 10.4 F5 MTHFR
20 mesenteric vascular occlusion 10.4 F2 MTHFR
21 hepatoportal sclerosis 10.4 ACE F2
22 impotence 10.4
23 paracetamol poisoning 10.3 F2 F5
24 cardia cancer 10.3 GSTM1 GSTT1 MTHFR
25 inherited blood coagulation disease 10.3 F2 GP1BA ITGB3
26 sticky platelet syndrome 10.3 F5 ITGB3
27 glanzmann thrombasthenia 10.3 F2 GP1BA ITGB3
28 blood platelet disease 10.3 F2 GP1BA ITGB3
29 vasculogenic impotence 10.3 ACE NOS3 PDE5A
30 isolated cleft lip 10.3 GSTM1 GSTT1
31 buerger disease 10.3 F2 MTHFR NOS3
32 sexual disorder 10.3 ACE NOS3 PDE5A
33 varicocele 10.3 GSTM1 GSTT1 NOS3
34 bernard-soulier syndrome 10.3 F2 GP1BA ITGB3
35 hepatic vascular disease 10.3 F2 MTHFR NOS3
36 acute lymphocytic leukemia 10.3 GSTM1 GSTT1 MTHFR
37 priapism 10.3 F5 NOS3 PDE5A
38 renal artery disease 10.3 ACE NOS3
39 cerebral sinovenous thrombosis 10.3 F2 F5
40 spinal cord infarction 10.3 F2 F5 MTHFR
41 cryptogenic cirrhosis 10.2 F2 F5 MTHFR
42 porencephaly 10.2 F2 F5 MTHFR
43 thrombophlebitis 10.2 F2 F5 MTHFR
44 antithrombin iii deficiency 10.2 F2 F5 MTHFR
45 cerebral atherosclerosis 10.2 ACE MTHFR
46 blood protein disease 10.2 F2 F5 MTHFR
47 malignant otitis externa 10.2 CRP F2
48 portal vein thrombosis 10.2 F2 F5 MTHFR
49 pulmonary artery disease 10.2 F2 F5 MTHFR
50 protein s deficiency 10.2 F2 F5 MTHFR

Graphical network of the top 20 diseases related to Arteritic Anterior Ischemic Optic Neuropathy:



Diseases related to Arteritic Anterior Ischemic Optic Neuropathy

Symptoms & Phenotypes for Arteritic Anterior Ischemic Optic Neuropathy

MGI Mouse Phenotypes related to Arteritic Anterior Ischemic Optic Neuropathy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 ACE ATOH7 CRP F2 F5 ITGB3
2 liver/biliary system MP:0005370 9.17 ACE F5 ITGB3 LEFTY2 MAPK14 MTHFR

Drugs & Therapeutics for Arteritic Anterior Ischemic Optic Neuropathy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 OCT Angiography in Arteritic and Non Arteritic Anterior Ischemic Neuropathy Recruiting NCT03642899

Search NIH Clinical Center for Arteritic Anterior Ischemic Optic Neuropathy

Genetic Tests for Arteritic Anterior Ischemic Optic Neuropathy

Anatomical Context for Arteritic Anterior Ischemic Optic Neuropathy

MalaCards organs/tissues related to Arteritic Anterior Ischemic Optic Neuropathy:

42
Heart, Eye, Neutrophil, Brain, Endothelial, Kidney, Spinal Cord

Publications for Arteritic Anterior Ischemic Optic Neuropathy

Articles related to Arteritic Anterior Ischemic Optic Neuropathy:

(show top 50) (show all 105)
# Title Authors Year
1
Giant cell arteritis related arteritic anterior ischemic optic neuropathy: Clinico-pathological correlation. ( 30574925 )
2019
2
Characterization of retinal microvasculature in acute non-arteritic anterior ischemic optic neuropathy using the retinal functional imager: a prospective case series. ( 30675495 )
2019
3
Systemic oxidative stress in non-arteritic anterior ischemic optic neuropathy. ( 30833666 )
2019
4
Abnormal spontaneous brain activity in patients with non-arteritic anterior ischemic optic neuropathy detected using functional magnetic resonance imaging. ( 30855358 )
2019
5
Choroidal Vascular Changes in Arteritic and Non-arteritic Anterior Ischemic Optic Neuropathy. ( 30954470 )
2019
6
Retinal Vessel Phenotype in Patients with Non-Arteritic Anterior Ischemic Optic Neuropathy. ( 31004591 )
2019
7
Anomalous coagulation factors in non-arteritic anterior ischemic optic neuropathy with central retinal vein occlusion: A case report. ( 29642215 )
2018
8
The polymorphisms of ATOH 7, ET-1 and ACE in non-arteritic anterior ischemic optic neuropathy. ( 29792847 )
2018
9
The Association Between Phosphodiesterase Type 5 Inhibitor Use and Risk of Non-Arteritic Anterior Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis. ( 29884471 )
2018
10
Quantitative analysis of optical coherence tomographic angiography (OCT-A) in patients with non-arteritic anterior ischemic optic neuropathy (NAION) corresponds to visual function. ( 29953490 )
2018
11
Three-Dimensional High-Resolution Black-Blood Magnetic Resonance Imaging for Detection of Arteritic Anterior Ischemic Optic Neuropathy in Patients With Giant Cell Arteritis. ( 30095558 )
2018
12
Giant Cell Arteritis Associated Arteritic Anterior Ischemic Optic Neuropathy: Sudden Vision Loss on the Contralateral Side of Headache. ( 30198237 )
2018
13
Non-Arteritic Anterior Ischemic Optic Neuropathy in Pilots. ( 30352654 )
2018
14
Non-arteritic anterior ischemic optic neuropathy - Case report. ( 30505994 )
2018
15
OCT angiography of acute non-arteritic anterior ischemic optic neuropathy. ( 28117076 )
2017
16
High-dose intravenous pulse steroid therapy for optic disc swelling and subretinal fluid in non-arteritic anterior ischemic optic neuropathy. ( 28303068 )
2017
17
Postural effects on intraocular pressure and ocular perfusion pressure in patients with non-arteritic anterior ischemic optic neuropathy. ( 28427356 )
2017
18
Giant cell arteritis with arteritic anterior ischemic optic neuropathy. ( 28523333 )
2017
19
The Effect of Combined Systemic Erythropoietin and Steroid on Non-arteritic Anterior Ischemic Optic Neuropathy: A Prospective Study. ( 28632028 )
2017
20
Atrial fibrillation in retinal vascular occlusion disease and non-arteritic anterior ischemic optic neuropathy. ( 28771491 )
2017
21
Visual outcome following bilateral non-arteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis. ( 28836961 )
2017
22
Optical coherence tomography angiography in acute arteritic and non-arteritic anterior ischemic optic neuropathy. ( 28861697 )
2017
23
Sequential development of non-arteritic anterior ischemic optic neuropathy in a patient on hemodialysis. ( 28944153 )
2017
24
Optical coherence tomography angiography of optic disc perfusion in non-arteritic anterior ischemic optic neuropathy. ( 28944200 )
2017
25
Bilateral Arteritic Anterior Ischemic Optic Neuropathy Associated with Giant Cell Arteritis in Korea. ( 28994270 )
2017
26
A case of non-arteritic anterior ischemic optic neuropathy after completion of Harvoni therapy. ( 29260058 )
2017
27
Comparison of Optic Nerve Head Morphology in Patients with Primary Open Angle Glaucoma and Non-Arteritic Anterior Ischemic Optic Neuropathy. ( 29485789 )
2017
28
Glutathione-S-Transferase Deletions and Non-arteritic Anterior Ischemic Optic Neuropathy. ( 25990411 )
2016
29
Change of Retinal Nerve Layer Thickness in Non-Arteritic Anterior Ischemic Optic Neuropathy Revealed by Fourier Domain Optical Coherence Tomography. ( 26580572 )
2016
30
Early macular ganglion cell-inner plexiform layer analysis in non-arteritic anterior ischemic optic neuropathy. ( 26631135 )
2016
31
Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION): A Review and Update on Animal Models. ( 26959135 )
2016
32
Arteritic Anterior Ischemic Optic Neuropathy Associated with Giant Cell Arteritis in an Elderly Korean Man. ( 27247526 )
2016
33
Retinal Ganglion Cell Layer Thinning Within One Month of Presentation for Non-Arteritic Anterior Ischemic Optic Neuropathy. ( 27388052 )
2016
34
The effect of high-dose steroids, and normobaric oxygen therapy, on recent onset non-arteritic anterior ischemic optic neuropathy: a randomized clinical trial. ( 27510295 )
2016
35
Clinical and color Doppler imaging features of one patient with occult giant cell arteritis presenting arteritic anterior ischemic optic neuropathy. ( 27516038 )
2016
36
Choroidal thickness in Chinese patients with non-arteritic anterior ischemic optic neuropathy. ( 27580594 )
2016
37
Could Topical Minoxidil Cause Non-Arteritic Anterior Ischemic Optic Neuropathy? ( 27656541 )
2016
38
Analysis of optic disc damage by optical coherence tomography in terms of therapy in non-arteritic anterior ischemic optic neuropathy. ( 27672604 )
2016
39
Neutrophil-to-Lymphocyte Ratio and Non-arteritic Anterior Ischemic Optic Neuropathy. ( 27761294 )
2016
40
Giant Cell Arteritis With Arteritic Anterior Ischemic Optic Neuropathy Is Bilateral Until Proven Otherwise. ( 27855128 )
2016
41
Temporal Arteritis With Arteritic Anterior Ischemic Optic Neuropathy is Bilateral Until Proven Otherwise: Response. ( 27855129 )
2016
42
Non arteritic anterior ischemic optic neuropathy; does Anticoagulation help? ( 28586576 )
2016
43
Letter to the Editor for 'Neutrophil-to-Lymphocyte Ratio as a Marker in Patients with Non-arteritic Anterior Ischemic Optic Neuropathy'. ( 27606152 )
2016
44
A study of prevalence and risk factors of diabetic retinopathy in patients with non-arteritic anterior ischemic optic neuropathy (NA-AION). ( 24171808 )
2015
45
Comparison of peripapillary retinal nerve fiber layer loss and visual outcome in fellow eyes following sequential bilateral non-arteritic anterior ischemic optic neuropathy. ( 25153943 )
2015
46
Choroidal thickness in non-arteritic anterior ischemic optic neuropathy. ( 25488646 )
2015
47
Protective effects of systemic treatment with methylprednisolone in a rodent model of non-arteritic anterior ischemic optic neuropathy (rAION). ( 25543054 )
2015
48
Macular star formation in diabetic patients with non-arteritic anterior ischemic optic neuropathy (NA-AION). ( 25859144 )
2015
49
Delayed non-arteritic anterior ischemic optic neuropathy following acute primary angle closure. ( 26028953 )
2015
50
Corticosteroid therapy in patients with non-arteritic anterior ischemic optic neuropathy. ( 26040070 )
2015

Variations for Arteritic Anterior Ischemic Optic Neuropathy

Expression for Arteritic Anterior Ischemic Optic Neuropathy

Search GEO for disease gene expression data for Arteritic Anterior Ischemic Optic Neuropathy.

Pathways for Arteritic Anterior Ischemic Optic Neuropathy

Pathways related to Arteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.69 F2 F5 GP1BA ITGB3 LEFTY2 MAPK14
2
Show member pathways
12.04 CRP F2 MPO MTHFR
3
Show member pathways
11.82 F2 F5 GP1BA PRTN3
4 11.75 GP1BA ITGB3 MPO
5 11.65 GP1BA ITGB3 MAPK14 NOS3
6
Show member pathways
11.64 F2 GP1BA ITGB3
7 11.5 GSTM1 MPO PRTN3
8 11.16 GSTM1 GSTT1 ITGB3 MAPK14 NOS3
9 10.79 GSTM1 GSTT1 MPO
10 10.67 GSTT1 MPO
11 10.57 NOS3 PDE5A
12 10.15 GSTM1 MPO

GO Terms for Arteritic Anterior Ischemic Optic Neuropathy

Cellular components related to Arteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 ACE CRP F2 F5 GP1BA LEFTY2

Biological processes related to Arteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet activation GO:0030168 9.61 F2 GP1BA ITGB3
2 blood coagulation, intrinsic pathway GO:0007597 9.46 F2 GP1BA
3 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.4 CRP ITGB3
4 regulation of blood coagulation GO:0030193 9.37 F2 GP1BA
5 removal of superoxide radicals GO:0019430 9.32 MPO NOS3
6 negative regulation of lipid storage GO:0010888 9.26 CRP ITGB3
7 negative regulation of platelet activation GO:0010544 9.16 F2 NOS3
8 hemostasis GO:0007599 9.13 F2 F5 GP1BA
9 blood coagulation GO:0007596 9.02 F2 F5 GP1BA ITGB3 PRTN3

Sources for Arteritic Anterior Ischemic Optic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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