MCID: ART110
MIFTS: 40

Arteritic Anterior Ischemic Optic Neuropathy

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Arteritic Anterior Ischemic Optic Neuropathy

MalaCards integrated aliases for Arteritic Anterior Ischemic Optic Neuropathy:

Name: Arteritic Anterior Ischemic Optic Neuropathy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050863

Summaries for Arteritic Anterior Ischemic Optic Neuropathy

MalaCards based summary : Arteritic Anterior Ischemic Optic Neuropathy is related to nonarteritic anterior ischemic optic neuropathy and ischemic optic neuropathy. An important gene associated with Arteritic Anterior Ischemic Optic Neuropathy is ITGB3 (Integrin Subunit Beta 3), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and Response to elevated platelet cytosolic Ca2+. Affiliated tissues include eye, neutrophil and endothelial, and related phenotypes are cardiovascular system and liver/biliary system

Related Diseases for Arteritic Anterior Ischemic Optic Neuropathy

Diseases related to Arteritic Anterior Ischemic Optic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)
# Related Disease Score Top Affiliating Genes
1 nonarteritic anterior ischemic optic neuropathy 33.6 ACE F2 F5 GP1BA MTHFR NOS3
2 ischemic optic neuropathy 30.7 ACE F2 F5 GP1BA GSTM1 GSTT1
3 central retinal vein occlusion 30.6 F2 F5 MTHFR
4 retinal vein occlusion 30.6 F2 F5 MTHFR
5 thrombophilia 30.6 F2 F5 MTHFR
6 antiphospholipid syndrome 30.6 F2 F5 MTHFR
7 retinal artery occlusion 30.4 ACE F2 F5 MTHFR
8 retinal vascular occlusion 30.4 F2 F5 FANCG MTHFR
9 sleep apnea 30.3 ACE CRP NOS3
10 optic nerve disease 11.2
11 neuropathy 11.2
12 temporal arteritis 10.7
13 open-angle glaucoma 10.3
14 impotence 10.3
15 fetal and neonatal alloimmune thrombocytopenia 10.3 GP1BA ITGB3
16 inferior vena cava interruption 10.3 F5 MTHFR
17 paracetamol poisoning 10.3 F2 F5
18 amaurosis fugax 10.3 F5 MTHFR
19 hearing loss, noise-induced 10.3 GSTM1 GSTT1
20 mesenteric vascular occlusion 10.3 F2 MTHFR
21 hemifacial spasm 10.3 MTHFR NOS3
22 hepatoportal sclerosis 10.3 ACE F2
23 sister chromatid exchange, frequency of 10.2 GSTM1 GSTT1
24 inherited blood coagulation disease 10.2 F2 GP1BA ITGB3
25 sticky platelet syndrome 10.2 F5 ITGB3
26 cerebral sinovenous thrombosis 10.2 F2 F5
27 spinal cord infarction 10.2 F2 F5 MTHFR
28 cryptogenic cirrhosis 10.2 F2 F5 MTHFR
29 porencephaly 10.2 F2 F5 MTHFR
30 glanzmann thrombasthenia 10.2 F2 GP1BA ITGB3
31 thrombophlebitis 10.2 F2 F5 MTHFR
32 gastroschisis 10.2 F2 F5 MTHFR
33 blood platelet disease 10.2 F2 GP1BA ITGB3
34 antithrombin iii deficiency 10.2 F2 F5 MTHFR
35 blood protein disease 10.2 F2 F5 MTHFR
36 cardia cancer 10.2 GSTM1 GSTT1 MTHFR
37 portal vein thrombosis 10.2 F2 F5 MTHFR
38 pulmonary artery disease 10.2 F2 F5 MTHFR
39 protein s deficiency 10.2 F2 F5 MTHFR
40 von willebrand's disease 10.2 F2 F5 GP1BA
41 placental abruption 10.2 F2 F5 MTHFR
42 protein c deficiency 10.2 F2 F5 MTHFR
43 vein disease 10.2 F2 F5 MTHFR
44 intracranial hypertension 10.2 F2 F5 MTHFR
45 bernard-soulier syndrome 10.2 F2 GP1BA ITGB3
46 buerger disease 10.2 F2 MTHFR NOS3
47 thrombophilia due to activated protein c resistance 10.2 F2 F5 MTHFR
48 hemoglobin e disease 10.2 F2 F5
49 hepatic vascular disease 10.2 F2 MTHFR NOS3
50 budd-chiari syndrome 10.2 F2 F5 MTHFR

Graphical network of the top 20 diseases related to Arteritic Anterior Ischemic Optic Neuropathy:



Diseases related to Arteritic Anterior Ischemic Optic Neuropathy

Symptoms & Phenotypes for Arteritic Anterior Ischemic Optic Neuropathy

MGI Mouse Phenotypes related to Arteritic Anterior Ischemic Optic Neuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.61 ACE CRP F2 F5 ITGB3 LEFTY2
2 liver/biliary system MP:0005370 9.17 ACE F5 ITGB3 LEFTY2 MAPK14 MTHFR

Drugs & Therapeutics for Arteritic Anterior Ischemic Optic Neuropathy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 OCT Angiography in Arteritic and Non Arteritic Anterior Ischemic Neuropathy Recruiting NCT03642899

Search NIH Clinical Center for Arteritic Anterior Ischemic Optic Neuropathy

Genetic Tests for Arteritic Anterior Ischemic Optic Neuropathy

Anatomical Context for Arteritic Anterior Ischemic Optic Neuropathy

MalaCards organs/tissues related to Arteritic Anterior Ischemic Optic Neuropathy:

41
Eye, Neutrophil, Endothelial, Kidney, Heart, Spinal Cord, Monocytes

Publications for Arteritic Anterior Ischemic Optic Neuropathy

Articles related to Arteritic Anterior Ischemic Optic Neuropathy:

(show top 50) (show all 100)
# Title Authors Year
1
Quantitative analysis of optical coherence tomographic angiography (OCT-A) in patients with non-arteritic anterior ischemic optic neuropathy (NAION) corresponds to visual function. ( 29953490 )
2018
2
The polymorphisms of ATOH 7, ET-1 and ACE in non-arteritic anterior ischemic optic neuropathy. ( 29792847 )
2018
3
Anomalous coagulation factors in non-arteritic anterior ischemic optic neuropathy with central retinal vein occlusion: A case report. ( 29642215 )
2018
4
The Association Between Phosphodiesterase Type 5 Inhibitor Use and Risk of Non-Arteritic Anterior Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis. ( 29884471 )
2018
5
Three-Dimensional High-Resolution Black-Blood Magnetic Resonance Imaging for Detection of Arteritic Anterior Ischemic Optic Neuropathy in Patients With Giant Cell Arteritis. ( 30095558 )
2018
6
Giant Cell Arteritis Associated Arteritic Anterior Ischemic Optic Neuropathy: Sudden Vision Loss on the Contralateral Side of Headache. ( 30198237 )
2018
7
Non-Arteritic Anterior Ischemic Optic Neuropathy in Pilots. ( 30352654 )
2018
8
Non-arteritic anterior ischemic optic neuropathy - Case report. ( 30505994 )
2018
9
The Effect of Combined Systemic Erythropoietin and Steroid on Non-arteritic Anterior Ischemic Optic Neuropathy: A Prospective Study. ( 28632028 )
2017
10
High-dose intravenous pulse steroid therapy for optic disc swelling and subretinal fluid in non-arteritic anterior ischemic optic neuropathy. ( 28303068 )
2017
11
Optical coherence tomography angiography in acute arteritic and non-arteritic anterior ischemic optic neuropathy. ( 28861697 )
2017
12
Atrial fibrillation in retinal vascular occlusion disease and non-arteritic anterior ischemic optic neuropathy. ( 28771491 )
2017
13
Bilateral Arteritic Anterior Ischemic Optic Neuropathy Associated with Giant Cell Arteritis in Korea. ( 28994270 )
2017
14
Comparison of Optic Nerve Head Morphology in Patients with Primary Open Angle Glaucoma and Non-Arteritic Anterior Ischemic Optic Neuropathy. ( 29485789 )
2017
15
Visual outcome following bilateral non-arteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis. ( 28836961 )
2017
16
Postural effects on intraocular pressure and ocular perfusion pressure in patients with non-arteritic anterior ischemic optic neuropathy. ( 28427356 )
2017
17
Giant cell arteritis with arteritic anterior ischemic optic neuropathy. ( 28523333 )
2017
18
A case of non-arteritic anterior ischemic optic neuropathy after completion of Harvoni therapy. ( 29260058 )
2017
19
Sequential development of non-arteritic anterior ischemic optic neuropathy in a patient on hemodialysis. ( 28944153 )
2017
20
OCT angiography of acute non-arteritic anterior ischemic optic neuropathy. ( 28117076 )
2017
21
Optical coherence tomography angiography of optic disc perfusion in non-arteritic anterior ischemic optic neuropathy. ( 28944200 )
2017
22
Arteritic Anterior Ischemic Optic Neuropathy Associated with Giant Cell Arteritis in an Elderly Korean Man. ( 27247526 )
2016
23
The effect of high-dose steroids, and normobaric oxygen therapy, on recent onset non-arteritic anterior ischemic optic neuropathy: a randomized clinical trial. ( 27510295 )
2016
24
Non arteritic anterior ischemic optic neuropathy; does Anticoagulation help? ( 28586576 )
2016
25
Analysis of optic disc damage by optical coherence tomography in terms of therapy in non-arteritic anterior ischemic optic neuropathy. ( 27672604 )
2016
26
Temporal Arteritis With Arteritic Anterior Ischemic Optic Neuropathy is Bilateral Until Proven Otherwise: Response. ( 27855129 )
2016
27
Clinical and color Doppler imaging features of one patient with occult giant cell arteritis presenting arteritic anterior ischemic optic neuropathy. ( 27516038 )
2016
28
Early macular ganglion cell-inner plexiform layer analysis in non-arteritic anterior ischemic optic neuropathy. ( 26631135 )
2016
29
Neutrophil-to-Lymphocyte Ratio and Non-arteritic Anterior Ischemic Optic Neuropathy. ( 27761294 )
2016
30
Giant Cell Arteritis With Arteritic Anterior Ischemic Optic Neuropathy Is Bilateral Until Proven Otherwise. ( 27855128 )
2016
31
Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION): A Review and Update on Animal Models. ( 26959135 )
2016
32
Increased Risk of Stroke in Patients with Non-arteritic Anterior Ischemic Optic Neuropathy: A Nationwide Retrospective Cohort Study. ( 27521605 )
2016
33
Choroidal thickness in Chinese patients with non-arteritic anterior ischemic optic neuropathy. ( 27580594 )
2016
34
Could Topical Minoxidil Cause Non-Arteritic Anterior Ischemic Optic Neuropathy? ( 27656541 )
2016
35
Retinal Ganglion Cell Layer Thinning Within One Month of Presentation for Non-Arteritic Anterior Ischemic Optic Neuropathy. ( 27388052 )
2016
36
Delayed non-arteritic anterior ischemic optic neuropathy following acute primary angle closure. ( 26028953 )
2015
37
Intravitreal injection of a Rho-kinase inhibitor (fasudil) for recent onset non-arteritic anterior ischemic optic neuropathy. ( 26444290 )
2015
38
Cataract surgery as a risk factor for non-arteritic anterior ischemic optic neuropathy and the intra-operative use of intravitreal corticosteroid. ( 26622149 )
2015
39
Acute Monocular Blindness after Carotid Endarterectomy due to Non-arteritic Anterior Ischemic Optic Neuropathy. ( 26286388 )
2015
40
Corticosteroid therapy in patients with non-arteritic anterior ischemic optic neuropathy. ( 26040070 )
2015
41
Choroidal thickness in non-arteritic anterior ischemic optic neuropathy. ( 25488646 )
2015
42
Protective effects of systemic treatment with methylprednisolone in a rodent model of non-arteritic anterior ischemic optic neuropathy (rAION). ( 25543054 )
2015
43
Steroid-induced central serous chorioretinopathy in a patient with non-arteritic anterior ischemic optic neuropathy. ( 26155086 )
2015
44
Macular star formation in diabetic patients with non-arteritic anterior ischemic optic neuropathy (NA-AION). ( 25859144 )
2015
45
Obstructive sleep apnea syndrome and non-arteritic anterior ischemic optic neuropathy: a case control study. ( 26913263 )
2015
46
Differences between Non-arteritic Anterior Ischemic Optic Neuropathy and Open Angle Glaucoma with Altitudinal Visual Field Defect. ( 26635459 )
2015
47
Glutathione-S-Transferase Deletions and Non-arteritic Anterior Ischemic Optic Neuropathy. ( 25990411 )
2015
48
Change of Retinal Nerve Layer Thickness in Non-Arteritic Anterior Ischemic Optic Neuropathy Revealed by Fourier Domain Optical Coherence Tomography. ( 26580572 )
2015
49
Neutrophil-to-Lymphocyte Ratio as a Marker in Patients with Non-arteritic Anterior Ischemic Optic Neuropathy. ( 26740898 )
2015
50
Translational Preclinical Research may Lead to Improved Medical Management of Non-Arteritic Anterior Ischemic Optic Neuropathy. ( 25071709 )
2014

Variations for Arteritic Anterior Ischemic Optic Neuropathy

Expression for Arteritic Anterior Ischemic Optic Neuropathy

Search GEO for disease gene expression data for Arteritic Anterior Ischemic Optic Neuropathy.

Pathways for Arteritic Anterior Ischemic Optic Neuropathy

Pathways related to Arteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.36 F2 MAPK14 MPO NOS3
2
Show member pathways
12.35 F2 F5 GP1BA ITGB3 LEFTY2 MAPK14
3
Show member pathways
12.04 CRP F2 MPO MTHFR
4
Show member pathways
11.82 F2 F5 GP1BA PRTN3
5 11.75 GP1BA ITGB3 MPO
6 11.65 GP1BA ITGB3 MAPK14 NOS3
7
Show member pathways
11.64 F2 GP1BA ITGB3
8 11.5 GSTM1 MPO PRTN3
9 11.5 GSTM1 GSTT1 ITGB3 MAPK14 NOS3
10 10.79 GSTM1 GSTT1 MPO
11 10.67 GSTT1 MPO
12 10.57 NOS3 PDE5A
13 10.15 GSTM1 MPO

GO Terms for Arteritic Anterior Ischemic Optic Neuropathy

Cellular components related to Arteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 ACE CRP F2 F5 GP1BA LEFTY2

Biological processes related to Arteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.65 F5 ITGB3 LEFTY2
2 platelet activation GO:0030168 9.61 F2 GP1BA ITGB3
3 blood coagulation, intrinsic pathway GO:0007597 9.46 F2 GP1BA
4 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.4 CRP ITGB3
5 regulation of blood coagulation GO:0030193 9.37 F2 GP1BA
6 removal of superoxide radicals GO:0019430 9.32 MPO NOS3
7 negative regulation of lipid storage GO:0010888 9.26 CRP ITGB3
8 negative regulation of platelet activation GO:0010544 9.16 F2 NOS3
9 hemostasis GO:0007599 9.13 F2 F5 GP1BA
10 blood coagulation GO:0007596 9.02 F2 F5 GP1BA ITGB3 PRTN3

Sources for Arteritic Anterior Ischemic Optic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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