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MCID: ART110
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Arteritic Anterior Ischemic Optic Neuropathy

Categories: Eye diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Arteritic Anterior Ischemic Optic Neuropathy

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MalaCards integrated aliases for Arteritic Anterior Ischemic Optic Neuropathy:

Name: Arteritic Anterior Ischemic Optic Neuropathy 12 15

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Eye diseases
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Disease Ontology 12 DOID:0050863
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Summaries for Arteritic Anterior Ischemic Optic Neuropathy

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Disease Ontology : 12 An anterior ischemic optic neuropathy that is characterized by near-complete vision loss caused by damage to the medium-sized blood vessels supplying the optic nerves following temporal arteritis.

MalaCards based summary : Arteritic Anterior Ischemic Optic Neuropathy is related to nonarteritic anterior ischemic optic neuropathy and thrombophilia. An important gene associated with Arteritic Anterior Ischemic Optic Neuropathy is ITGB3 (Integrin Subunit Beta 3), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. The drugs Dopamine and Levodopa have been mentioned in the context of this disorder. Affiliated tissues include eye, neutrophil and retina, and related phenotypes are cardiovascular system and liver/biliary system

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Related Diseases for Arteritic Anterior Ischemic Optic Neuropathy

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Diseases related to Arteritic Anterior Ischemic Optic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 nonarteritic anterior ischemic optic neuropathy 33.5 PDE5A NOS3 MTHFR GP1BA F5 F2
2 thrombophilia 31.5 MTHFR F5 F2
3 retinal vein occlusion 31.4 MTHFR F5 F2
4 central retinal vein occlusion 31.2 MTHFR F5 F2
5 protein s deficiency 31.1 MTHFR F5 F2
6 open-angle glaucoma 31.1 GSTT1 GSTM1 ATOH7
7 thrombophilia due to activated protein c resistance 31.1 MTHFR F5 F2
8 retinal artery occlusion 31.1 MTHFR F5 F2 ACE
9 branch retinal artery occlusion 31.1 MTHFR FANCG F2
10 antiphospholipid syndrome 31.1 MTHFR F5 F2
11 ischemic neuropathy 31.0 MTHFR F2 CRP
12 sleep apnea 31.0 NOS3 CRP ACE
13 retinal vascular occlusion 30.5 MTHFR FANCG F5 F2
14 cerebrovascular disease 30.4 MTHFR F5 F2 CRP ACE
15 vasculitis 30.2 PRTN3 MPO CRP
16 stroke, ischemic 29.7 NOS3 MTHFR F5 F2 CRP ACE
17 anca-associated vasculitis 29.7 PRTN3 MPO
18 vascular disease 28.7 NOS3 MTHFR MPO ITGB3 GP1BA F5
19 optic nerve disease 11.3
20 neuropathy 11.3
21 fetal and neonatal alloimmune thrombocytopenia 10.8 ITGB3 GP1BA
22 hepatoportal sclerosis 10.7 F2 ACE
23 paracetamol poisoning 10.7 F5 F2
24 amaurosis fugax 10.7 MTHFR F5
25 mesenteric vascular occlusion 10.7 MTHFR F2
26 hemifacial spasm 10.6 NOS3 MTHFR
27 sticky platelet syndrome 10.6 ITGB3 F5
28 inherited blood coagulation disease 10.6 ITGB3 GP1BA F2
29 hearing loss, noise-induced 10.6 GSTT1 GSTM1
30 cerebral sinovenous thrombosis 10.6 F5 F2
31 impotence 10.6
32 spinal cord infarction 10.6 MTHFR F5 F2
33 blood platelet disease 10.6 ITGB3 GP1BA F2
34 glanzmann thrombasthenia 10.6 ITGB3 GP1BA F2
35 cryptogenic cirrhosis 10.6 MTHFR F5 F2
36 sister chromatid exchange, frequency of 10.6 GSTT1 GSTM1
37 porencephaly 10.6 MTHFR F5 F2
38 thrombophlebitis 10.6 MTHFR F5 F2
39 antithrombin iii deficiency 10.6 MTHFR F5 F2
40 blood protein disease 10.6 MTHFR F5 F2
41 portal vein thrombosis 10.5 MTHFR F5 F2
42 pulmonary artery disease 10.5 MTHFR F5 F2
43 von willebrand's disease 10.5 GP1BA F5 F2
44 placental abruption 10.5 MTHFR F5 F2
45 vein disease 10.5 MTHFR F5 F2
46 bernard-soulier syndrome 10.5 ITGB3 GP1BA F2
47 protein c deficiency 10.5 MTHFR F5 F2
48 intracranial hypertension 10.5 MTHFR F5 F2
49 budd-chiari syndrome 10.5 MTHFR F5 F2
50 hemoglobin e disease 10.5 F5 F2

Graphical network of the top 20 diseases related to Arteritic Anterior Ischemic Optic Neuropathy:



Diseases related to Arteritic Anterior Ischemic Optic Neuropathy
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Symptoms & Phenotypes for Arteritic Anterior Ischemic Optic Neuropathy

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MGI Mouse Phenotypes related to Arteritic Anterior Ischemic Optic Neuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 ACE ATOH7 CRP F2 F5 ITGB3
2 liver/biliary system MP:0005370 9.17 ACE F5 ITGB3 LEFTY2 MAPK14 MTHFR
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Drugs & Therapeutics for Arteritic Anterior Ischemic Optic Neuropathy

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Drugs for Arteritic Anterior Ischemic Optic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Levodopa Approved Phase 4 59-92-7 6047
3
Carbidopa Approved Phase 4 28860-95-9 34359
4
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
5
Choline Approved, Nutraceutical Phase 4 62-49-7 305
6 Neurotransmitter Agents Phase 4
7 Dopamine Agents Phase 4
8 Antiparkinson Agents Phase 4
9 Adjuvants, Immunologic Phase 4
10 Immunologic Factors Phase 4
11 Dopamine agonists Phase 4
12 Aromatic Amino Acid Decarboxylase Inhibitors Phase 4
13 Carbidopa, levodopa drug combination Phase 4
14 Nootropic Agents Phase 4
15 Cytidine Diphosphate Choline Phase 4
16 Sildenafil Citrate Phase 4 171599-83-0
17 Phosphodiesterase Inhibitors Phase 4
18 Phosphodiesterase 5 Inhibitors Phase 4
19 Vardenafil Dihydrochloride Phase 4
20
Bevacizumab Approved, Investigational Phase 2 216974-75-3
21
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
22
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
23
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
24
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
25
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
26 Angiogenesis Inhibitors Phase 2
27 Angiogenesis Modulating Agents Phase 2
28 Antineoplastic Agents, Immunological Phase 2
29 Neuroprotective Agents Phase 2
30 Gastrointestinal Agents Phase 2
31 Anti-Inflammatory Agents Phase 2
32 glucocorticoids Phase 2
33 Hormones Phase 2
34 Methylprednisolone Acetate Phase 2
35 Antiemetics Phase 2
36 Peripheral Nervous System Agents Phase 2
37 Antineoplastic Agents, Hormonal Phase 2
38 Protective Agents Phase 2
39 Hormone Antagonists Phase 2
40 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
41 Prednisolone acetate Phase 2
42 Autonomic Agents Phase 2
43 Epoetin alfa Phase 2 113427-24-0
44 Hematinics Phase 2

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy Completed NCT00432393 Phase 4 levodopa-carbidopa
2 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) : Pattern Electroretinography Study Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
3 Prospective Case Crossover Study to Assess Whether PDE5 Inhibitor Exposure in Men Increases the Risk for the Development of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Terminated NCT00867815 Phase 4 Diagnostic procedures
4 The Effect of High Dose Steroid and Normobaric Oxygen Therapy on Recent Onset Non-arteritic Anterior Ischemic Optic Neuropathy(NAION); a Randomized Clinical Trial Unknown status NCT02439866 Phase 3 placebo;Intravenous methylprednisolone;normobaric oxygen with face mask
5 A Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 Delivered By Single or Multi-Dose Intravitreal Injection(s) to Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Terminated NCT02341560 Phase 2, Phase 3 QPI-1007 Injection - 1.5 mg;QPI-1007 Injection - 3.0 mg
6 Intravitreal Bevacizumab for Treatment of the Second Eye With Non-Arteritic Ischemic Optic Neuropathy Unknown status NCT00813059 Phase 2 Intra-vitreal injection of bevacizumab (1.25mg/0.05ml)
7 Phase II Safety Assessment of Intravitreal Injection of Mesenchymal Stem Cells for Acute Non Arteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT03173638 Phase 2
8 Scientific Title: Efficacy of Oral Prednisolone and Erythropoietin Injection in Treatment of Acute Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT03715881 Phase 2 Oral prednisolone administration 50 mg;Intravenous Erythropoietin injection
9 A Phase I Open-Label, Dose Escalation Trial of QPI-1007 Delivered by a Single Intravitreal Injection to Patients With Optic Nerve Atrophy (Stratum I) and Acute Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) (Stratum II) Completed NCT01064505 Phase 1 QPI-1007 at various doses
10 Can Urgent Reduction of Intraocular Pressure With Ophthalmic Timolol Improve Recovery From Non-arteritic Anterior Ischemic Optic Neuropathy (NAION): a Randomized Study. Withdrawn NCT01607671 Phase 1 Timolol maleate
11 The Detection and Epidemiology of NAION in a Commercially Insured Population in the United States. Completed NCT01260324
12 Visual Field Defects in Non-Arteritic Anterior Ischemic Optic Neuropathy: Effect of Vision Restoration Therapy (VRT) Completed NCT00140491
13 Evaluation of the Effectiveness and Safety of Transcorneal Electrical Stimulation to Improve Visual Function After Ocular Trauma Completed NCT02019927
14 Retinal Neuro-vascular Coupling in Patients With Non-arteritic Anterior Ischemic Optic Neuropathy Recruiting NCT03401892

Search NIH Clinical Center for Arteritic Anterior Ischemic Optic Neuropathy

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Genetic Tests for Arteritic Anterior Ischemic Optic Neuropathy

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Anatomical Context for Arteritic Anterior Ischemic Optic Neuropathy

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MalaCards organs/tissues related to Arteritic Anterior Ischemic Optic Neuropathy:

41
Eye, Neutrophil, Retina, Brain, Endothelial
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Publications for Arteritic Anterior Ischemic Optic Neuropathy

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Articles related to Arteritic Anterior Ischemic Optic Neuropathy:

(show top 50) (show all 219)
# Title Authors PMID Year
1
Systemic oxidative stress in non-arteritic anterior ischemic optic neuropathy. 38
30833666 2019
2
Arteritic Anterior Ischemic Optic Neuropathy Associated with Giant-Cell Arteritis in Korean Patients: A Retrospective Single-Center Analysis and Review of the Literature. 38
31286712 2019
3
Two Cases of Segmental Disc Oedema and Normal Visual Acuity in Giant Cell Arteritis. 38
31312246 2019
4
Visual loss post Ross procedure in an adolescent with newly diagnosed Mucopolysaccharidosis Type II. 38
30953652 2019
5
Retinal Vessel Phenotype in Patients with Non-Arteritic Anterior Ischemic Optic Neuropathy. 38
31004591 2019
6
Choroidal Vascular Changes in Arteritic and Non-arteritic Anterior Ischemic Optic Neuropathy. 38
30954470 2019
7
[Vessel density and structure in the macular region of non-arteritic anterior ischemic optic neuropathy patients]. 38
30841686 2019
8
Abnormal spontaneous brain activity in patients with non-arteritic anterior ischemic optic neuropathy detected using functional magnetic resonance imaging. 38
30855358 2019
9
Lamina cribrosa position and Bruch's membrane opening differences between anterior ischemic optic neuropathy and open-angle glaucoma. 38
29911429 2019
10
Ischemic optic neuropathy in robotic-assisted gynaecologic surgery: A case report. 38
30520549 2019
11
[Pay attention to the quality of evidence research for appropriate evaluation of the treatment trail of the non-arteritic anterior ischemic optic neuropathy]. 38
30841682 2019
12
Visual Impairment After Haemodialysis. 38
30723524 2019
13
Characterization of retinal microvasculature in acute non-arteritic anterior ischemic optic neuropathy using the retinal functional imager: a prospective case series. 38
30675495 2019
14
Disc Configuration as a Risk and Prognostic Factor in NAION: The Impact of Cup to Disc Ratio, Disc Diameter, and Crowding Index. 38
31162995 2019
15
Giant cell arteritis related arteritic anterior ischemic optic neuropathy: Clinico-pathological correlation. 38
30574925 2019
16
Non-Arteritic Anterior Ischemic Optic Neuropathy in Pilots. 38
30352654 2018
17
Three-Dimensional High-Resolution Black-Blood Magnetic Resonance Imaging for Detection of Arteritic Anterior Ischemic Optic Neuropathy in Patients With Giant Cell Arteritis. 38
30095558 2018
18
Could Platelet Indices and Neutrophil to Lymphocyte Ratio Be New Biomarkers for Differentiation of Arteritic Anterior Ischemic Neuropathy from Non-Arteritic Type? 38
30258474 2018
19
Incidence and Mimickers of Acute Idiopathic Optic Neuritis: Analysis of 291 Consecutive Patients from Southern Finland. 38
30040514 2018
20
Acute visual loss and optic disc edema followed by optic atrophy in two cases with deeply buried optic disc drusen: a mimicker of atypical optic neuritis. 38
30367617 2018
21
Giant Cell Arteritis Associated Arteritic Anterior Ischemic Optic Neuropathy: Sudden Vision Loss on the Contralateral Side of Headache. 38
30198237 2018
22
The polymorphisms of ATOH 7, ET-1 and ACE in non-arteritic anterior ischemic optic neuropathy. 38
29792847 2018
23
The Association Between Phosphodiesterase Type 5 Inhibitor Use and Risk of Non-Arteritic Anterior Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis. 38
29884471 2018
24
Non-arteritic anterior ischemic optic neuropathy - Case report. 38
30505994 2018
25
Critical flicker fusion frequency in demyelinating and ischemic optic neuropathies. 38
28527029 2018
26
Prognosis and monitoring of giant cell arteritis and associated complications. 38
29676201 2018
27
Anomalous coagulation factors in non-arteritic anterior ischemic optic neuropathy with central retinal vein occlusion: A case report. 38
29642215 2018
28
Pattern of peripapillary capillary density loss in ischemic optic neuropathy compared to that in primary open-angle glaucoma. 38
29320503 2018
29
Optical coherence tomography angiography at the acute phase of optic disc edema. 38
29977949 2018
30
Quantitative analysis of optical coherence tomographic angiography (OCT-A) in patients with non-arteritic anterior ischemic optic neuropathy (NAION) corresponds to visual function. 38
29953490 2018
31
Relative Frequencies of Arteritic and Nonarteritic Anterior Ischemic Optic Neuropathy in an Arab Population. 38
28099197 2017
32
Optical coherence tomography angiography in acute arteritic and non-arteritic anterior ischemic optic neuropathy. 38
28861697 2017
33
Bilateral Arteritic Anterior Ischemic Optic Neuropathy Associated with Giant Cell Arteritis in Korea. 38
28994270 2017
34
Tocilizumab for giant cell arteritis with corticosteroid-resistant progressive anterior ischemic optic neuropathy. 38
28499892 2017
35
Carotid artery intimal medial thickness and carotid artery plaques in hypertensive patients with non-arteritic anterior ischaemic optic neuropathy. 38
28733725 2017
36
[Bilateral acute arteritic anterior ischemic optic neuropathy during chronic steroid therapy]. 38
28801036 2017
37
Visual outcome following bilateral non-arteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis. 38
28836961 2017
38
Crowded optic nerve head evaluation with optical coherence tomography in anterior ischemic optic neuropathy. 38
28387764 2017
39
The Effect of Combined Systemic Erythropoietin and Steroid on Non-arteritic Anterior Ischemic Optic Neuropathy: A Prospective Study. 38
28632028 2017
40
A case of non-arteritic anterior ischemic optic neuropathy after completion of Harvoni therapy. 38
29260058 2017
41
Comparison of Optic Nerve Head Morphology in Patients with Primary Open Angle Glaucoma and Non-Arteritic Anterior Ischemic Optic Neuropathy. 38
29485789 2017
42
[OCT angiography and choroidal ischemia related to arteritic anterior ischemic optic neuropathy]. 38
28395906 2017
43
Postural effects on intraocular pressure and ocular perfusion pressure in patients with non-arteritic anterior ischemic optic neuropathy. 38
28427356 2017
44
The diagnostic accuracy of chromatic pupillary light responses in diseases of the outer and inner retina. 38
27785596 2017
45
High-dose intravenous pulse steroid therapy for optic disc swelling and subretinal fluid in non-arteritic anterior ischemic optic neuropathy. 38
28303068 2017
46
OCT angiography of acute non-arteritic anterior ischemic optic neuropathy. 38
28117076 2017
47
Giant cell arteritis with arteritic anterior ischemic optic neuropathy. 38
28523333 2017
48
OCULAR ARTERIAL OCCLUSIVE DISORDERS AND CAROTID ARTERY DISEASE. 38
28547004 2017
49
Sequential development of non-arteritic anterior ischemic optic neuropathy in a patient on hemodialysis. 38
28944153 2017
50
Optical coherence tomography angiography of optic disc perfusion in non-arteritic anterior ischemic optic neuropathy. 38
28944200 2017
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Variations for Arteritic Anterior Ischemic Optic Neuropathy

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Expression for Arteritic Anterior Ischemic Optic Neuropathy

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Search GEO for disease gene expression data for Arteritic Anterior Ischemic Optic Neuropathy.
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Pathways for Arteritic Anterior Ischemic Optic Neuropathy

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Pathways related to Arteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 66
Show member pathways
 12.69 PRTN3 PDE5A NOS3 MAPK14 LEFTY2 ITGB3
2
Selenium Micronutrient Network 1
Show member pathways
 12.04 MTHFR MPO F2 CRP
3
Formation of Fibrin Clot (Clotting Cascade) 66
Show member pathways
 11.82 PRTN3 GP1BA F5 F2
4
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.75 MPO ITGB3 GP1BA
5
Platelet activation 37
11.65 NOS3 MAPK14 ITGB3 GP1BA
6
Integrin alphaIIb beta3 signaling 66
Show member pathways
 11.64 ITGB3 GP1BA F2
7
C-MYB transcription factor network 1
11.5 PRTN3 MPO GSTM1
8
Fluid shear stress and atherosclerosis 37
11.16 NOS3 MAPK14 ITGB3 GSTT1 GSTM1
9
Platinum Pathway, Pharmacokinetics/Pharmacodynamics 61
10.79 MPO GSTT1 GSTM1
10
Etoposide Pathway, Pharmacokinetics/Pharmacodynamics 61
10.67 MPO GSTT1
11
NO-dependent CFTR activation (normal and CF) 22
10.57 PDE5A NOS3
12
Benzene metabolism 1
10.15 MPO GSTM1
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GO Terms for Arteritic Anterior Ischemic Optic Neuropathy

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Cellular components related to Arteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 PRTN3 MPO LEFTY2 GP1BA F5 F2

Biological processes related to Arteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet activation GO:0030168 9.61 ITGB3 GP1BA F2
2 blood coagulation, intrinsic pathway GO:0007597 9.46 GP1BA F2
3 removal of superoxide radicals GO:0019430 9.4 NOS3 MPO
4 regulation of blood coagulation GO:0030193 9.37 GP1BA F2
5 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.32 ITGB3 CRP
6 negative regulation of platelet activation GO:0010544 9.26 NOS3 F2
7 negative regulation of lipid storage GO:0010888 9.16 ITGB3 CRP
8 hemostasis GO:0007599 9.13 GP1BA F5 F2
9 blood coagulation GO:0007596 9.02 PRTN3 ITGB3 GP1BA F5 F2
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Sources for Arteritic Anterior Ischemic Optic Neuropathy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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