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MCID: ART110
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Arteritic Anterior Ischemic Optic Neuropathy

Categories: Eye diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Arteritic Anterior Ischemic Optic Neuropathy

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MalaCards integrated aliases for Arteritic Anterior Ischemic Optic Neuropathy:

Name: Arteritic Anterior Ischemic Optic Neuropathy 12 15

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Eye diseases
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Disease Ontology 12 DOID:0050863
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Summaries for Arteritic Anterior Ischemic Optic Neuropathy

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Disease Ontology : 12 An anterior ischemic optic neuropathy that is characterized by near-complete vision loss caused by damage to the medium-sized blood vessels supplying the optic nerves following temporal arteritis.

MalaCards based summary : Arteritic Anterior Ischemic Optic Neuropathy is related to nonarteritic anterior ischemic optic neuropathy and branch retinal artery occlusion. An important gene associated with Arteritic Anterior Ischemic Optic Neuropathy is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Formation of Fibrin Clot (Clotting Cascade). The drugs Tadalafil and Choline have been mentioned in the context of this disorder. Affiliated tissues include eye, neutrophil and retina, and related phenotypes are Increased shRNA abundance and liver/biliary system

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Related Diseases for Arteritic Anterior Ischemic Optic Neuropathy

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Diseases related to Arteritic Anterior Ischemic Optic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 217)
# Related Disease Score Top Affiliating Genes
1 nonarteritic anterior ischemic optic neuropathy 31.8 NOS3 MTHFR GP1BA F5 F2 ACE
2 branch retinal artery occlusion 31.0 MTHFR F2
3 central retinal artery occlusion 30.6 MTHFR F2
4 papilledema 30.5 F2 ACE
5 open-angle glaucoma 30.5 NOS3 MTHFR ACE
6 retinal vascular disease 30.4 NOS3 MTHFR ACE
7 apnea, obstructive sleep 30.3 NOS3 ACE
8 thrombophilia 30.3 MTHFR ITGB3 F5 F2
9 ischemia 30.2 NOS3 GP1BA ACE
10 retinal vascular occlusion 30.1 MTHFR F5 F2
11 central retinal vein occlusion 30.1 MTHFR F5 F2
12 thrombophilia due to activated protein c resistance 30.1 MTHFR F5 F2
13 protein s deficiency 30.1 MTHFR F5 F2
14 end stage renal disease 30.1 NOS3 MTHFR ACE
15 antiphospholipid syndrome 30.1 MTHFR F5 F2
16 retinal artery occlusion 30.1 MTHFR F5 F2 ACE
17 retinal vein occlusion 30.0 MTHFR F5 F2 ACE
18 arteriosclerosis 29.9 NOS3 ITGB3 GP1BA ACE
19 thrombocytopenia 29.5 MTHFR ITGB3 GP1BA F5 F2
20 vascular disease 29.1 NOS3 MTHFR ITGB3 GP1BA F5 F2
21 cerebrovascular disease 29.1 MTHFR ITGB3 GP1BA F5 F2 ACE
22 optic nerve disease 11.3
23 neuropathy 11.3
24 impotence 10.6
25 intraocular pressure quantitative trait locus 10.5
26 vasculitis 10.5
27 temporal arteritis 10.5
28 yemenite deaf-blind hypopigmentation syndrome 10.5
29 sleep apnea 10.5
30 posttransplant acute limbic encephalitis 10.5
31 glaucoma, primary open angle 10.4
32 3-methylglutaconic aciduria, type iii 10.4
33 leber hereditary optic neuropathy, modifier of 10.4
34 microvascular complications of diabetes 5 10.4
35 ischemic neuropathy 10.4
36 retinal ischemia 10.4
37 lipid metabolism disorder 10.4
38 compartment syndrome 10.4
39 hereditary optic neuropathy 10.4
40 fetal and neonatal alloimmune thrombocytopenia 10.2 ITGB3 GP1BA
41 hypercholesterolemia, familial, 1 10.2
42 exfoliation syndrome 10.2
43 strabismus 10.2
44 type 1 diabetes mellitus 10.2
45 pseudoxanthoma elasticum 10.2
46 macular degeneration, age-related, 1 10.2
47 angioid streaks 10.2
48 androgenic alopecia 10.2
49 atrial fibrillation 10.2
50 covid-19 10.2

Graphical network of the top 20 diseases related to Arteritic Anterior Ischemic Optic Neuropathy:



Diseases related to Arteritic Anterior Ischemic Optic Neuropathy
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Symptoms & Phenotypes for Arteritic Anterior Ischemic Optic Neuropathy

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GenomeRNAi Phenotypes related to Arteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 F5 ITGB3 MTHFR

MGI Mouse Phenotypes related to Arteritic Anterior Ischemic Optic Neuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.02 ACE F5 ITGB3 MTHFR NOS3
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Drugs & Therapeutics for Arteritic Anterior Ischemic Optic Neuropathy

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Drugs for Arteritic Anterior Ischemic Optic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
2
Choline Approved, Nutraceutical Phase 4 62-49-7 305
3 Cytidine Diphosphate Choline Phase 4
4 Phosphodiesterase 5 Inhibitors Phase 4
5 Vardenafil Dihydrochloride Phase 4
6 Sildenafil Citrate Phase 4 171599-83-0
7
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
8 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
9
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
10
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
11
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
12
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
13 Protective Agents Phase 3
14 Gastrointestinal Agents Phase 3
15 Anti-Inflammatory Agents Phase 3
16 Hormone Antagonists Phase 3
17 Hormones Phase 3
18 glucocorticoids Phase 3
19 Methylprednisolone Acetate Phase 3
20 Antineoplastic Agents, Hormonal Phase 3
21 Antiemetics Phase 3
22
Bevacizumab Approved, Investigational Phase 2 216974-75-3
23 Angiogenesis Inhibitors Phase 2
24 Antineoplastic Agents, Immunological Phase 2
25 Hematinics Phase 2
26 Epoetin alfa Phase 2 113427-24-0
27 Neuroprotective Agents Phase 1

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) : Pattern Electroretinography Study Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
2 Prospective Case Crossover Study to Assess Whether PDE5 Inhibitor Exposure in Men Increases the Risk for the Development of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Terminated NCT00867815 Phase 4 Diagnostic procedures
3 The Effect of High Dose Steroid and Normobaric Oxygen Therapy on Recent Onset Non-arteritic Anterior Ischemic Optic Neuropathy(NAION); a Randomized Clinical Trial Unknown status NCT02439866 Phase 3 placebo;Intravenous methylprednisolone;normobaric oxygen with face mask
4 A Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 Delivered By Single or Multi-Dose Intravitreal Injection(s) to Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Terminated NCT02341560 Phase 2, Phase 3 QPI-1007 Injection - 1.5 mg;QPI-1007 Injection - 3.0 mg
5 Intravitreal Bevacizumab for Treatment of the Second Eye With Non-Arteritic Ischemic Optic Neuropathy Unknown status NCT00813059 Phase 2 Intra-vitreal injection of bevacizumab (1.25mg/0.05ml)
6 Scientific Title: Efficacy of Oral Prednisolone and Erythropoietin Injection in Treatment of Acute Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Unknown status NCT03715881 Phase 2 Oral prednisolone administration 50 mg;Intravenous Erythropoietin injection
7 Phase II Safety Assessment of Intravitreal Injection of Mesenchymal Stem Cells for Acute Non Arteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT03173638 Phase 2
8 A Phase I Open-Label, Dose Escalation Trial of QPI-1007 Delivered by a Single Intravitreal Injection to Patients With Optic Nerve Atrophy (Stratum I) and Acute Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) (Stratum II) Completed NCT01064505 Phase 1 QPI-1007 at various doses
9 Can Urgent Reduction of Intraocular Pressure With Ophthalmic Timolol Improve Recovery From Non-arteritic Anterior Ischemic Optic Neuropathy (NAION): a Randomized Study. Withdrawn NCT01607671 Phase 1 Timolol maleate
10 Evaluation of the Effectiveness and Safety of Transcorneal Electrical Stimulation to Improve Visual Function After Ocular Trauma Completed NCT02019927
11 Visual Field Defects in Non-Arteritic Anterior Ischemic Optic Neuropathy: Effect of Vision Restoration Therapy (VRT) Completed NCT00140491
12 Retinal Neuro-vascular Coupling in Patients With Non-arteritic Anterior Ischemic Optic Neuropathy Recruiting NCT03401892

Search NIH Clinical Center for Arteritic Anterior Ischemic Optic Neuropathy

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Genetic Tests for Arteritic Anterior Ischemic Optic Neuropathy

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Anatomical Context for Arteritic Anterior Ischemic Optic Neuropathy

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MalaCards organs/tissues related to Arteritic Anterior Ischemic Optic Neuropathy:

40
Eye, Neutrophil, Retina, Brain, Endothelial
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Publications for Arteritic Anterior Ischemic Optic Neuropathy

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Articles related to Arteritic Anterior Ischemic Optic Neuropathy:

(show top 50) (show all 249)
# Title Authors PMID Year
1
A Promising Strategy for Non-Arteritic Anterior Ischemic Optic Neuropathy: Intravitreal Mesenchymal Stem Cell Exosome. 61
32798377 2021
2
OCT angiography analysis in acute non-arteritic anterior ischemic optic neuropathy: The importance of segmentation. 61
33307804 2020
3
A Case of Non-Arteritic Anterior Ischemic Optic Neuropathy with COVID-19. 61
33425529 2020
4
Serum Inflammatory Biomarkers in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy. 61
33307608 2020
5
Bilateral diabetic papillopathy developed after starting insulin treatment. Potential toxic effect of insulin? A case report. 61
33353425 2020
6
Bilateral optic disc edema with preserved visual function not related to papilledema. 61
33010652 2020
7
Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) Following a Hypovolemic Episode of Gastric Bleeding. 61
33376641 2020
8
Efficacy of Vincamine treatment in a rat model of anterior ischemic optic neuropathy. 61
33222520 2020
9
Analysis of Macular Microperimetry Characteristics in Non-Arteritic Anterior Ischemic Optic Neuropathy. 61
33216737 2020
10
The effect of systemic erythropoietin and oral prednisolone on recent-onset non-arteritic anterior ischemic optic neuropathy: a randomized clinical trial. 61
32506278 2020
11
Licorice associated bilateral non-arteritic anterior ischemic optic neuropathy. 61
33069444 2020
12
The Usefulness of the Erythrocyte Sedimentation Rate and C-reactive Protein for the Differential Diagnosis of Non-Arteritic Anterior Ischemic Optic Neuropathy in the Era of Microinflammation. 61
32946299 2020
13
Aircraft Cabin Pressurization and Concern for Non-Arteritic Anterior Ischemic Optic Neuropathy. 61
32867902 2020
14
Non-arteritic anterior ischemic optic neuropathy after intravitreal aflibercept for age-related macular degeneration. 61
32969978 2020
15
Vision Loss From Giant Cell Arteritis in Patients With Other Ocular Diagnoses. 61
32868559 2020
16
A neuroglia-based interpretation of glaucomatous neuroretinal rim thinning in the optic nerve head. 61
31982595 2020
17
Neuroprotective effects of low-dose G-CSF plus meloxicam in a rat model of anterior ischemic optic neuropathy. 61
32587280 2020
18
Assessment of peripapillary vessel density in acute non-arteritic anterior ischemic optic neuropathy. 61
31960199 2020
19
Choroidal Thickness in Acute Non-arteritic Anterior Ischemic Optic Neuropathy. 61
32095210 2020
20
Prospective analysis of macular and optic disc changes after non-arteritic anterior ischemic optic neuropathy. 61
31706462 2020
21
Neuro-Ophthalmological Manifestations of Obstructive Sleep Apnea: Current Perspectives. 61
32753994 2020
22
Acute changes in ganglion cell layer thickness in ischemic optic neuropathy compared to optic neuritis using optical coherence tomography. 61
31956579 2020
23
Non artheritic bilateral anterior ischaemic optic neuropathy (NAION) as devastating complication following Total Hip Arthroplasty: a case report. 61
31910190 2019
24
Neuro-Ophthalmologic Complications of Giant Cell Arteritis: Diagnosis and Treatment. 61
31847038 2019
25
Unraveling the Enigma of Nonarteritic Anterior Ischemic Optic Neuropathy. 61
31790002 2019
26
Steroids in the treatment of nonarteritic anterior ischemic optic neuropathy: A PRISMA-compliant meta-analysis. 61
31725628 2019
27
Non-arteritic anterior ischemic optic neuropathy with Cilioretinal artery occlusion: a case report. 61
31726996 2019
28
Acute Unilateral Anterior Ischemic Optic Neuropathy Secondary to Optic Nerve Head Drusen: Report of a Rare Coexistence. 61
31741680 2019
29
[Non-arteritic Anterior Ischaemic Optic Neuropathy: Pathogenesis and Therapeutic Approaches]. 61
31711249 2019
30
[Value of Optical Coherence Tomography Angiography in Neuroophthalmology]. 61
31509884 2019
31
Choroidal Vascular Changes in Arteritic and Nonarteritic Anterior Ischemic Optic Neuropathy. 61
30954470 2019
32
[Optic nerve morphology and vessel density in eyes with different phases of non-arteritic anterior ischemic optic neuropathy]. 61
31495153 2019
33
Arteritic Anterior Ischemic Optic Neuropathy Associated with Giant-Cell Arteritis in Korean Patients: A Retrospective Single-Center Analysis and Review of the Literature. 61
31286712 2019
34
Systemic oxidative stress in non-arteritic anterior ischemic optic neuropathy. 61
30833666 2019
35
Two Cases of Segmental Disc Oedema and Normal Visual Acuity in Giant Cell Arteritis. 61
31312246 2019
36
Ischemic optic neuropathy in robotic-assisted gynaecologic surgery: A case report. 61
30520549 2019
37
Lamina cribrosa position and Bruch's membrane opening differences between anterior ischemic optic neuropathy and open-angle glaucoma. 61
29911429 2019
38
Abnormal spontaneous brain activity in patients with non-arteritic anterior ischemic optic neuropathy detected using functional magnetic resonance imaging. 61
30855358 2019
39
[Pay attention to the quality of evidence research for appropriate evaluation of the treatment trail of the non-arteritic anterior ischemic optic neuropathy]. 61
30841682 2019
40
[Vessel density and structure in the macular region of non-arteritic anterior ischemic optic neuropathy patients]. 61
30841686 2019
41
Visual Impairment After Haemodialysis. 61
30723524 2019
42
Disc Configuration as a Risk and Prognostic Factor in NAION: The Impact of Cup to Disc Ratio, Disc Diameter, and Crowding Index. 61
31162995 2019
43
Bilateral simultaneous non-arteritic anterior ischemic optic neuropathy with occlusion of unilateral cilioretinal artery: A case report. 61
31909390 2019
44
Giant cell arteritis related arteritic anterior ischemic optic neuropathy: Clinico-pathological correlation. 61
30574925 2019
45
Characterization of retinal microvasculature in acute non-arteritic anterior ischemic optic neuropathy using the retinal functional imager: a prospective case series. 61
30675495 2019
46
Non-Arteritic Anterior Ischemic Optic Neuropathy in Pilots. 61
30352654 2018
47
Three-Dimensional High-Resolution Black-Blood Magnetic Resonance Imaging for Detection of Arteritic Anterior Ischemic Optic Neuropathy in Patients With Giant Cell Arteritis. 61
30095558 2018
48
Giant Cell Arteritis Associated Arteritic Anterior Ischemic Optic Neuropathy: Sudden Vision Loss on the Contralateral Side of Headache. 61
30198237 2018
49
Acute visual loss and optic disc edema followed by optic atrophy in two cases with deeply buried optic disc drusen: a mimicker of atypical optic neuritis. 61
30367617 2018
50
Could Platelet Indices and Neutrophil to Lymphocyte Ratio Be New Biomarkers for Differentiation of Arteritic Anterior Ischemic Neuropathy from Non-Arteritic Type? 61
30258474 2018
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Variations for Arteritic Anterior Ischemic Optic Neuropathy

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Expression for Arteritic Anterior Ischemic Optic Neuropathy

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Search GEO for disease gene expression data for Arteritic Anterior Ischemic Optic Neuropathy.
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Pathways for Arteritic Anterior Ischemic Optic Neuropathy

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Pathways related to Arteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 65
Show member pathways
 12.63 NOS3 ITGB3 GP1BA F5 F2
2
Formation of Fibrin Clot (Clotting Cascade) 65
Show member pathways
 11.63 GP1BA F5 F2
3
Integrin alphaIIb beta3 signaling 65
Show member pathways
 11.12 ITGB3 GP1BA F2
4
Platelet Aggregation Inhibitor Pathway, Pharmacodynamics 60
11.03 ITGB3 F2
5
Platelet activation 36
11.02 NOS3 ITGB3 GP1BA F2
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GO Terms for Arteritic Anterior Ischemic Optic Neuropathy

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Biological processes related to Arteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet aggregation GO:0070527 9.48 ITGB3 GP1BA
2 blood vessel remodeling GO:0001974 9.46 NOS3 ACE
3 regulation of blood vessel diameter GO:0097746 9.43 NOS3 ACE
4 platelet activation GO:0030168 9.43 ITGB3 GP1BA F2
5 fibrinolysis GO:0042730 9.4 GP1BA F2
6 blood coagulation, intrinsic pathway GO:0007597 9.37 GP1BA F2
7 regulation of blood coagulation GO:0030193 9.32 GP1BA F2
8 negative regulation of platelet activation GO:0010544 9.16 NOS3 F2
9 hemostasis GO:0007599 9.13 GP1BA F5 F2
10 blood coagulation GO:0007596 8.92 ITGB3 GP1BA F5 F2

Molecular functions related to Arteritic Anterior Ischemic Optic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 8.62 NOS3 MTHFR
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Sources for Arteritic Anterior Ischemic Optic Neuropathy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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