Aliases & Classifications for Arthritis, Sacroiliac

MalaCards integrated aliases for Arthritis, Sacroiliac:

Name: Arthritis, Sacroiliac 56 6

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant


HPO:

31
arthritis, sacroiliac:
Inheritance autosomal dominant inheritance


External Ids:

OMIM 56 108100
MedGen 41 C0748473

Summaries for Arthritis, Sacroiliac

MalaCards based summary : Arthritis, Sacroiliac is related to arthritis and spondyloarthropathy 1. An important gene associated with Arthritis, Sacroiliac is RELN (Reelin). The drugs Prednisolone phosphate and Methylprednisolone have been mentioned in the context of this disorder. Related phenotypes are paresthesia and pruritus

More information from OMIM: 108100

Related Diseases for Arthritis, Sacroiliac

Diseases related to Arthritis, Sacroiliac via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 arthritis 10.3
2 spondyloarthropathy 1 9.9
3 rheumatoid arthritis 9.9
4 inflammatory spondylopathy 9.9
5 hyperostosis 9.9
6 ankylosis 9.9
7 spondylitis 9.9
8 diffuse idiopathic skeletal hyperostosis 9.9

Graphical network of the top 20 diseases related to Arthritis, Sacroiliac:



Diseases related to Arthritis, Sacroiliac

Symptoms & Phenotypes for Arthritis, Sacroiliac

Human phenotypes related to Arthritis, Sacroiliac:

31
# Description HPO Frequency HPO Source Accession
1 paresthesia 31 very rare (1%) HP:0003401
2 pruritus 31 HP:0000989
3 sacroiliac arthritis 31 HP:0012317

Symptoms via clinical synopsis from OMIM:

56
Genitourinary Kidneys:
renal disease, uncharacterized (in some patients)

Skeletal Hands:
swelling (in some patients)
tingling (in some patients)
itching ( in some patients)

Laboratory Abnormalities:
elevated uric acid on urinalysis (in some patients)

Skeletal Pelvis:
sacroiliac pain, intermittent, severe

Skeletal Feet:
swelling (in some patients)
tingling (in some patients)
itching ( in some patients)

Clinical features from OMIM:

108100

Drugs & Therapeutics for Arthritis, Sacroiliac

Drugs for Arthritis, Sacroiliac (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
2
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
3
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
4
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
5 Prednisolone acetate Approved, Vet_approved Phase 2, Phase 3 52-21-1
6
Prednisolone hemisuccinate Experimental Phase 2, Phase 3 2920-86-7
7 Hormones Phase 2, Phase 3
8 Antineoplastic Agents, Hormonal Phase 2, Phase 3
9 Methylprednisolone Acetate Phase 2, Phase 3
10 Hormone Antagonists Phase 2, Phase 3
11 glucocorticoids Phase 2, Phase 3
12 Antiemetics Phase 2, Phase 3
13 Neuroprotective Agents Phase 2, Phase 3
14 Protective Agents Phase 2, Phase 3
15 Gastrointestinal Agents Phase 2, Phase 3
16 Anti-Inflammatory Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison Between Intra-articular Pulsed Radiofrequency With Steroids Injection Versus Intra-articular Steroids Injection in Chronic Sacroiliac Joint Arthritis Recruiting NCT03564106 Phase 2, Phase 3 intraarticular radiofrequency + intraarticular methylprednisolone;intraarticular methylprednisolone

Search NIH Clinical Center for Arthritis, Sacroiliac

Genetic Tests for Arthritis, Sacroiliac

Anatomical Context for Arthritis, Sacroiliac

Publications for Arthritis, Sacroiliac

Articles related to Arthritis, Sacroiliac:

# Title Authors PMID Year
1
Distribution of HLA-B27 and CYP2D6*4 mutations in the middle Black Sea area (Tokat) of Turkey. 61
22180068 2011
2
[Chlamydia-associated arthritis and enteropathic arthritis--two important spondyloarthritides]. 61
21720100 2011
3
Sacroiliac joint involvement in psoriasis. 61
20354857 2010

Variations for Arthritis, Sacroiliac

ClinVar genetic disease variations for Arthritis, Sacroiliac:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 RELN NM_005045.4(RELN):c.7456A>G (p.Ser2486Gly)SNV Pathogenic 684430 7:103163872-103163872 7:103523425-103523425

Expression for Arthritis, Sacroiliac

Search GEO for disease gene expression data for Arthritis, Sacroiliac.

Pathways for Arthritis, Sacroiliac

GO Terms for Arthritis, Sacroiliac

Sources for Arthritis, Sacroiliac

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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