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MCID: ART023
MIFTS: 63

Arthropathy

Categories: Bone diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Arthropathy

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MalaCards integrated aliases for Arthropathy:

Name: Arthropathy 12 29 54 15 37 71
Joint Ankylosis of the Pelvic Region and Thigh 12
Ankylosis of Joint of Pelvic Region and Thigh 12
Joint Ankylosis of the Ankle and/or Foot 12
Ankylosis of Joint of Ankle and/or Foot 12
Joint Ankylosis of the Shoulder Region 12
Ankylosis of Joint of Shoulder Region 12
Joint Ankylosis of the Ankle and Foot 12
Arthropathy Associated with Infection 71
Ankylosis of Joint of Multiple Sites 12
Ankylosis of Ankle and Foot Joint 12
Joint Ankylosis of the Lower Leg 12
Joint Ankylosis of the Upper Arm 12
Ankylosis of Joint of Lower Leg 12
Ankylosis of Joint of Upper Arm 12
Joint Ankylosis of the Forearm 12
Ankylosis of Joint of Forearm 12
Ankylosis of Lower Leg Joint 12
Ankylosis of Multiple Joints 12
Ankylosis of Upper Arm Joint 12
Joint Ankylosis of the Hand 12
Ankylosis of Forearm Joint 12
Ankylosis of Joint of Hand 12
Ankylosis of Hand Joint 12
Infectious Arthropathy 12
Joint Diseases 43
Joint Disease 17

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:381
MeSH 43 D007592
UMLS 71 C0022408 C0157749
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Summaries for Arthropathy

About this section
Disease Ontology : 12 A bone disease that is located in the joint.

MalaCards based summary : Arthropathy, also known as joint ankylosis of the pelvic region and thigh, is related to hemophilic arthropathy and reactive arthritis, and has symptoms including joint stiffness, arthralgia and back pain. An important gene associated with Arthropathy is PRG4 (Proteoglycan 4), and among its related pathways/superpathways are IL-6 signaling pathway and Microglia Activation During Neuroinflammation: Overview. The drugs Prednisone and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and testes, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 74 An arthropathy is a disease of a joint. Arthritis is a form of arthropathy that involves inflammation of... more...

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Related Diseases for Arthropathy

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Diseases in the Arthropathy family:

Transient Arthropathy

Diseases related to Arthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 981)
# Related Disease Score Top Affiliating Genes
1 hemophilic arthropathy 34.2 TNFSF11 TNFRSF11B HFE COMP
2 reactive arthritis 33.7 TNF IL6 CRP COMP
3 psoriatic arthritis 33.0 TNFSF11 TNFRSF11B TNF MICA IL6 IL1RAPL2
4 ankylosis 33.0 TNFRSF11B TNF CRP ANKH
5 cinca syndrome 32.7 NLRP3 IL6 IL1RAPL2 CRP
6 osteoarthritis 32.5 TNFSF11 TNFRSF11B TNF PRG4 IL6 CRP
7 rheumatoid arthritis 32.0 TNFSF11 TNFRSF11B TNF MMP2 IL6 IL1RAPL2
8 chondrocalcinosis 31.7 TNFRSF11B NLRP3 HFE ANKH
9 enthesopathy 31.6 TNF CRP ACAN
10 multicentric reticulohistiocytosis 31.5 TNFSF11 TNFRSF11B
11 spondylitis 31.3 TNFSF11 TNF MICA IL6 CRP
12 spondyloarthropathy 31.3 TNFSF11 TNF IL6
13 spondyloepiphyseal dysplasia with congenital joint dislocations 31.3 TRPV4 COMP CCN6 ACAN
14 tenosynovitis 31.3 TNF IL6 CRP
15 pericarditis 31.3 TNF PRG4 IL6 CRP
16 rheumatic disease 31.2 TNFRSF11B TNF IL1RAPL2 CRP
17 amyloidosis 31.2 TNF NLRP3 IL6 CRP B2M
18 synovitis 31.1 TNFSF11 TNFRSF11B TNF PRG4 IL6 CRP
19 osteomyelitis 31.1 TNFSF11 TNF NLRP3 IL6
20 exanthem 31.1 TNF NLRP3 IL6 CRP
21 peripheral nervous system disease 31.0 TRPV4 TNF IL6 CRP B2M
22 osteonecrosis 31.0 TNFSF11 TNFRSF11B TNF
23 spondyloarthropathy 1 30.9 TNFSF11 TNFRSF11B TNF IL1RAPL2 CRP B2M
24 hemophilia b 30.9 TNFRSF11B F9 F8
25 hyperostosis 30.8 TNFRSF11B MMP2 ANKH
26 tendinitis 30.8 TNF IL6 CRP COMP
27 iridocyclitis 30.8 TNF IL6 CRP
28 periarthritis 30.8 B2M ANKH
29 crohn's disease 30.8 TNF NLRP3 IL6 CRP
30 bone resorption disease 30.7 TNFSF11 TNFRSF11B TNF IL6 CRP
31 hypothyroidism 30.7 TNFRSF11B TNF F9 F8 CRP
32 collagen disease 30.6 TNF IL6 CRP
33 connective tissue disease 30.6 TNFSF11 TNFRSF11B TNF MICA IL6 CRP
34 iritis 30.6 TNF IL6 CRP
35 inflammatory bowel disease 30.6 TNF NLRP3 MMP2 MICA IL6 IL1RAPL2
36 inherited metabolic disorder 30.6 TNF IL6 HFE CRP
37 chondromalacia 30.6 TNF CRP COMP ACAN
38 pericardial effusion 30.6 NLRP3 IL6 CRP
39 relapsing polychondritis 30.6 IL6 CRP COMP
40 endocarditis 30.6 TNF IL6 CRP
41 acute cystitis 30.6 TNF IL6 CRP
42 brachydactyly 30.5 TRPV4 F8 COMP ACAN
43 brucellosis 30.5 TNF MICA IL6 CRP
44 celiac disease 1 30.5 TNF MICA IL6 HFE CRP
45 urticaria 30.5 TNF NLRP3 IL6 CRP
46 dysentery 30.5 TNF IL6 IL1RAPL2 CRP
47 chlamydia 30.5 TNF IL6 CRP
48 pyoderma 30.5 TNF NLRP3 CRP
49 urethritis 30.5 TNF IL6 CRP
50 amyloidosis aa 30.4 CRP B2M

Graphical network of the top 20 diseases related to Arthropathy:



Diseases related to Arthropathy
Sources

Symptoms & Phenotypes for Arthropathy

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UMLS symptoms related to Arthropathy:


joint stiffness, arthralgia, back pain, sciatica, muscle cramp, metatarsalgia, joint symptom, musculoskeletal symptom, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm, other symptoms referable to joint, shoulder region, other symptoms referable to joint, upper arm, other symptoms referable to joint, forearm, other symptoms referable to joint, hand, other symptoms referable to joint, pelvic region and thigh, other symptoms referable to joint, lower leg, other symptoms referable to joint, ankle and foot, other symptoms referable to joint, other specified sites, other symptoms referable to joint, multiple sites, other symptoms referable to joint, site unspecified

MGI Mouse Phenotypes related to Arthropathy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.1 ANKH B2M COMP CRP F8 F9
2 cardiovascular system MP:0005385 10.07 ANKH B2M COMP CRP F9 IL6
3 hematopoietic system MP:0005397 10.06 ANKH B2M F8 F9 HFE IL6
4 immune system MP:0005387 10 ANKH B2M COMP CRP F8 F9
5 limbs/digits/tail MP:0005371 9.5 ANKH COMP HFE NLRP3 TNF TNFRSF11B
6 skeleton MP:0005390 9.32 ANKH COMP HFE HGD IL6 MMP2
Sources

Drugs & Therapeutics for Arthropathy

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Drugs for Arthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 435)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2
Azithromycin Approved Phase 4 83905-01-5 447043 55185
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
5
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
6
Remifentanil Approved Phase 4 132875-61-7 60815
7
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
8
Prilocaine Approved Phase 4 721-50-6 4906
9
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
10 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
11
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
12
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
13
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
14
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
15
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
16
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
17
Tranexamic Acid Approved Phase 4 1197-18-8 5526
18
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
19
Aminocaproic acid Approved, Investigational Phase 4 60-32-2 564
20
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
21
Levomilnacipran Approved, Investigational Phase 4 96847-54-0
22
tannic acid Approved Phase 4 1401-55-4
23
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
24
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
25
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
26
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
27
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
28
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
29
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 5281106 54677470
30
Aceclofenac Approved, Investigational Phase 4 89796-99-6
31
Etanercept Approved, Investigational Phase 4 185243-69-0
32
Abatacept Approved Phase 4 332348-12-6 10237
33
Cefazolin Approved Phase 4 25953-19-9 33255 656510
34
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
35
Apremilast Approved, Investigational Phase 4 608141-41-9 11561674
36
Certolizumab pegol Approved Phase 4 428863-50-7
37
Infliximab Approved Phase 4 170277-31-3
38
Sodium citrate Approved, Investigational Phase 4 68-04-2
39
Allopurinol Approved Phase 4 315-30-0 2094
40
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
41
Norepinephrine Approved Phase 4 51-41-2 439260
42
Febuxostat Approved Phase 4 144060-53-7 134018
43
Cobalt Approved, Experimental Phase 4 7440-48-4 104729
44
Chromium Approved Phase 4 7440-47-3 27668
45
Acetaminophen Approved Phase 4 103-90-2 1983
46
Morphine Approved, Investigational Phase 4 57-27-2 5288826
47
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
48
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
49
Vancomycin Approved Phase 4 1404-90-6 441141 14969
50
Ibuprofen Approved Phase 4 15687-27-1 3672

Interventional clinical trials:

(show top 50) (show all 957)
# Name Status NCT ID Phase Drugs
1 Adalimumab to Mitigate Cardiovascular Risk in RA Patients With Well-Controlled Joint Disease Unknown status NCT01893996 Phase 4 Adalimumab;Placebo
2 Efficacy of Intra-articular Injection of Combined Hyaluronic Acid and Platelet-rich Plasma in Knee Degenerative Joint Disease Unknown status NCT03211650 Phase 4 hyaluronic Acid + platelet-rich plasma;hyaluronic acid;platelet-rich plasma
3 Subclinical Joint Bleeding in Irish Adults With Severe Haemophilia A on Personalised Prophylaxis Regimens Unknown status NCT02314325 Phase 4 ADVATE [Antihemophilic Factor (Recombinant)];ADVATE [Antihemophilic Factor (Recombinant)]
4 Targeting Synovitis in Early Rheumatoid Arthritis (TaSER). Intensive Management of Early Rheumatoid Arthritis Using Either Clinical or Musculoskeletal Ultrasound Assessment of Synovitis − a Randomised Study With Blinded Outcome Assessments Unknown status NCT00920478 Phase 4
5 Open Label Study of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
6 EVALUATION OF THE RELATIONSHIP BETWEEN EFFERVESCENT PARACETAMOL AND BLOOD PRESSURE. CLINICAL TRIAL. Unknown status NCT02514538 Phase 4 Non- effervescent Paracetamol kern;Effervescent paracetamol termalgin
7 A Randomized, Double-Blind, Two-Period Study to Evaluate the Safety and Efficacy of Etanercept on Skin and Joint Disease in Psoriasis Subjects With Psoriatic Arthritis. Completed NCT00245960 Phase 4 etanercept
8 Phase IV Study of Landmarks for Spinal Anesthesia Completed NCT02330185 Phase 4
9 Consequence of the Learning Curve in Direct Anterior Approach for Total Hip Replacement Completed NCT02645435 Phase 4
10 Randomized Controlled Doubleblind Pilot Study Comparing Analgosedation Concepts During Placement of Regional Anaesthesia With Either Fentanyl, Remifentanil, Clonidine, EMLA-Patch or Placebo in Regard of Pain Reduction. Completed NCT04026074 Phase 4 Fentanyl;Remifentanil;Clonidine;EMLA Cream;Placebo iv;Placebo salve
11 Viscosupplementation in Patients With Hemophilic Arthropathy Completed NCT01748201 Phase 4
12 Efficacy and Safety of the Infiltration of Autologous Plasma Rich in Growth Factors (PRGF) in the Symptomatic Treatment of Knee Osteoarthritis Completed NCT00782197 Phase 4
13 Pain After Total Knee Arthroplasty: a Comparison of Combined Continuous Adductor Canal Block With Infiltration of Local Anesthetic Between the Popliteal Artery and Capsule of the Knee Block Versus Continuous Adductor Canal Block Alone on Postoperative Analgesia Completed NCT03921034 Phase 4 Ropivacaine;Saline
14 Impact of Conservative Treatment by Custom-made Orthoses in Patients With Haemophilic Ankle Arthropathy Completed NCT00638001 Phase 4
15 Milnacipran for the Pain, Sensory Sensitization and Mood Changes in Knee Osteoarthritis Completed NCT01510457 Phase 4 Milnacipran;Placebo
16 Does Deep Neuromuscular Blockade Improve Operating Conditions During Total Hip Replacements? Completed NCT03219294 Phase 4 Vecuronium 0.1 mg/kg;Vecuronium 0.2mg/kg
17 Determining the Optimal Dose of Tranexamic Acid in Decreasing Blood Loss During Lower Extremity Total Joint Arthroplasty Completed NCT02584725 Phase 4 Tranexamic Acid
18 Fase IV Clinical Trial to Evaluate Chondroitin Sulphate Efficacy and Safety in Patients With Knee Osteoarthritis and Psoriasis Completed NCT00669123 Phase 4 Chondroitin sulphate;Placebo
19 A Prospective Study to Evaluate the Effect of rFVIII-FS in Different Prophylactic Regimens on Bleeding Events Frequency and Development of Arthropathy in Previously Treated and Minimally Treated Hemophilia A Pediatric Population. Completed NCT00632814 Phase 4 rFVIII-FS (Kogenate FS, BAY14-2222) 70 IU/kg, dosing once per week;rFVIII-FS (Kogenate FS, BAY14-2222), 70 IU/kg twice per week (30 IU/kg + 40 IU/kg);rFVIII-FS (Kogenate FS, BAY14-2222) 75 IU/kg, dosing three times per week (3 x 25 IU/kg)
20 Topical Application of Tranexamic Acid in Joint Arthroplasty Completed NCT01937559 Phase 4 Normal saline
21 Periarticular Injection With Bupivacaine For Post-Operative Pain Control In Total Knee Replacement: A Prospective Randomized Double-Blind Controlled Trial Completed NCT01364194 Phase 4 0.25% Bupivacaine;0.9% normal saline
22 A Prospective, Randomised, Uncontrolled, Single-Centre, Post-Market Surveillance Study To Evaluate The Performance Of SmartSet® HV and SmartSet® GHV Bone Cements In Primary Cemented Total Hip Arthroplasty(THA) Completed NCT00872066 Phase 4
23 A Double Blind Randomised Study Comparing Hyaluronic Acid, Corticosteroid and Placebo During Arthrocentesis for Temporomandibular Joint Dysfunction Completed NCT01524913 Phase 4 Hyaluronic acid;Corticosteroid;Lactated Ringers
24 A Randomized Controlled Trial of Tranexamic Acid and ε-Aminocaproic Acid to Reduce Blood Loss Following Total Knee Arthroplasty Completed NCT01873768 Phase 4 Tranexamic Acid (TXA);ε-Aminocaproic Acid (EACA)
25 Clinical Outcome With Attention to Functional Results One Year After Fixed or Mobile Bearing Total Knee Replacement in a Randomized Controlled Trial Completed NCT00822640 Phase 4
26 Hyaluronic Acid Evaluation as Adjuvant to Temporomandibular Joint Arthroscopy in Wilkes Stages Completed NCT04110587 Phase 4 Antibiotic therapy;corticosteroid;Antiinflammatories;Analgesics
27 The Effect of Subsartorial Saphenous Block on Postoperative Pain Following Major Ankle and Hind Foot Surgery Completed NCT02697955 Phase 4 Bupivacaine-epinephrine
28 Five-Year Outcome of Ceramic on Ceramic Bearing Versus Ceramic on Crossfire® Highly Cross-Linked Polyethylene Bearing in Primary Total Hip Arthroplasty: A Randomized Trial Completed NCT01522014 Phase 4
29 A Prospective, Randomised, Controlled, Single Centre, Blinded Study of the Wear Characteristics of Two Polyethylene Bearing Surfaces, Enduron vs. Marathon Completed NCT00208442 Phase 4
30 Whole Body Vibration Compared to Conventional Physiotherapy in Patients With Coxarthrosis: a Randomized, Controlled Study Completed NCT01279174 Phase 4
31 Comparison of the Effect of a Single Shot Saphenous Block With Plain Bupivacaine vs. Protracted Bupivacaine Mixture as a Supplement to Continuous Sciatic Catheter After Major Ankle and Foot Surgery Completed NCT02346110 Phase 4 Bupivacaine-adrenaline;Dexamethasone
32 Is Clinical Outcome of Robotic-Assisted TKA Better Than Conventional Manual TKA?Prospective, Randomized Study Completed NCT03659318 Phase 4
33 Can Bone Erosions Heal in Adalimumab (Humira) Treated Rheumatoid Arthritis Patients. An Imaging Study Using Computed Tomography and Magnetic Resonance Imaging. Completed NCT00696059 Phase 4 Adalimumab (Humira)
34 Is Ceramic-on-Ceramic THA Superior to Ceramic-on-Highly Cross-Linked Polyethylene THA in Patients Less Than 55 Years Old? Completed NCT03639532 Phase 4
35 Efficacy and Tolerability of Mud Packs Therapy in Osteoarthritis of the Hands: a One Year Follow-up Completed NCT00773682 Phase 4
36 A Multicentre Double-blind Randomised Controlled Trial to Assess the Clinical- and Cost-effectiveness of Facet-joint Injections in Selected Patients With Non-specific Low Back Pain: a Feasibility Study Completed NCT03339362 Phase 4
37 Efficacy and Safety of Intra-Articular Injections of Durolane® in the Treatment of Osteoarthritis in the Knee Completed NCT00731289 Phase 4 hyaluronic acid;triamcinolone
38 Functional Brain Imaging to Understand the Mechanisms of Pain Relief in Knee Osteoarthritis Completed NCT02208778 Phase 4 Duloxetine;Remifentanil;Placebo (for Remifentanil);Placebo (for Duloxetine)
39 A Phase IIIb Open-label run-in Double-blind, Placebo Controlled, Randomized Study to Evaluate the Safety/Efficacy of Certolizumab Pegol Administered Concomitantly With Stable-dose Methotrexate in Patients With Active Rheumatoid Arthritis. Completed NCT00580840 Phase 4 Certolizumab pegol;Certolizumab pegol
40 Randomized Controlled Trial of Tranexamic Acid in Total Knee Arthroplasty: Intravenous vs. Topical Completed NCT01940523 Phase 4 Topical Tranexamic Acid;Intravenous Tranexamic Acid
41 Effectiveness of Triamcinolone Hexacetonide Intra-articular Injection in Interphalangeal Joints: a 12 Weeks Randomized Controlled Trial in Osteoarthritis Hand Patients Completed NCT02102620 Phase 4 Intra-articular injection with corticosteroid;Intra-articular injection with lidocaine
42 A Comparison of Tramadol/Acetaminophen Tablets Maintenance Versus NSAID Maintenance After Tramadol/Acetaminophen and NSAID Combination Therapy in Knee Osteoarthritis Patients: Multicenter, Randomized, Open Comparative Study Completed NCT00635349 Phase 4 Meloxicam;Aceclofenac;Tramadol Hydrochloride Plus Acetaminophen
43 The Comparison of Knee Osteoarthritis Treatment With Single-dose of Bone Marrow Aspirate Concentrate, Single-dose of Leukocyte Rich Platelet Rich Plasma and 3 Injection of High Molecular Weight Hyaluronic Acid-A Randomized Clinical Trial Completed NCT03825133 Phase 4 Hyaluronic Acid
44 Effect of Regenerative Injection Therapy on Function and Pain in Patients With Knee Osteoarthritis Completed NCT01206634 Phase 4
45 Comparison Between Single Shot Peripheral Nerve Block and Continuous Infusion Via a On-Q Pump in Extremity Fracture Operations: a Randomized Prospective Control Trial Completed NCT02280291 Phase 4 lidocaine;Propofol;Fentanyl;epinephrine,;bupivacaine
46 Analgesic Duration of Interscalene Block After Outpatient Arthroscopic Shoulder Surgery With Intravenous Dexamethasone, Dexmedetomidine or Their Combination: A Randomized Controlled Trial Completed NCT03270033 Phase 4 Dexamethasone;Dexmedetomidine
47 Efficacy and Cost Effectiveness of Standard Versus Pharmacokinetic Dosing During Factor VIII Prophylaxis in Adult Patients With Severe Haemophilia A Completed NCT02697370 Phase 4 Pharmacokinetic based dosage change
48 Abatacept Bone Effects in Psoriatic Arthritis With Bone Biomarkers - ABEPSA _ BB Recruiting NCT04106804 Phase 4 Abatacept 125 MG/ML
49 Liposomal Bupivacaine Interscalene Nerve Block in Shoulder Arthroplasty: A Single Blinded Prospective Randomized Control Trial Recruiting NCT03663283 Phase 4 Liposomal Bupivacaine;Bupivacaine Hydrochloride
50 Perioperative Antibiotic Prophylaxis in Patients Undergoing Elective Total Knee Arthroplasty: A Prospective, Randomized, Open-label, Controlled Multi-center Trial Recruiting NCT03283878 Phase 4 Cefazolin

Search NIH Clinical Center for Arthropathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Arthropathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Arthropathy:
BioSeed-C, a 3D chondrocyte graft for the treatment of articular cartilage defects
ChondroCelect, chondrocytes for treatment of cartilage knee defects
Chondrosphere (ACT3D-CS), articular chondrocyte spheroids for treatment of cartilage knee defects
DeNovo NT, particulated juvenile cartilage for cartilage repair
MACI, cultured chondrocytes for articular cartilage damage in joints
RevaFlex, engineered tissue graft of juvenile cartilage for cartilage repair
Embryonic/Adult Cultured Cells Related to Arthropathy:
Chondrocytes embedded in a 3D polymer scaffold (BioSeed-C) PMIDs: 21540360 19711090 17451597
Articular cartilage-derived cells (ChondroCelect)
Articular chondrocyte spheroids (Chondrosphere)
Matrix-induced autologous cultured chondrocytes (MACI) PMIDs: 22922521 21257846 19966108 16632362 20880476 23880403 19755063 15278206 16320051 19169789 22539536 22483735 24175609 24005872 22885840 12810965 23618699
Juvenile neocartilage (RevaFlex) PMIDs: 11603712 23465950 19880363 15742595 21828366 20025455 21439468 20423988

Cochrane evidence based reviews: joint diseases

Sources

Genetic Tests for Arthropathy

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Genetic tests related to Arthropathy:

# Genetic test Affiliating Genes
1 Arthropathy 29
Sources

Anatomical Context for Arthropathy

About this section

The Foundational Model of Anatomy Ontology organs/tissues related to Arthropathy:

19
Joint

MalaCards organs/tissues related to Arthropathy:

40
Bone, Testes, T Cells, Skin, Bone Marrow, Spinal Cord, Liver
Sources

Publications for Arthropathy

About this section

Articles related to Arthropathy:

(show top 50) (show all 10372)
# Title Authors PMID Year
1
[Bone and joint diseases in children. Phosphaturic hormone, FGF23, and bone metabolism]. 61 54
20513948 2010
2
Precocious bilateral hip joint osteoarthritis is a "form-fruste" of the arthropathy of hereditary haemochromatosis. 61 54
19942354 2010
3
Factor VIII requirement to maintain a target plasma level in the prophylactic treatment of severe hemophilia A: influences of variance in pharmacokinetics and treatment regimens. 61 54
19943875 2010
4
[Monoclonal antibodies in chronic autoimmune inflammatory diseases]. 61 54
20035687 2009
5
New insights into BMP-7 mediated osteoblastic differentiation of primary human mesenchymal stem cells. 61 54
19306956 2009
6
Adipokines in the skeleton: influence on cartilage function and joint degenerative diseases. 61 54
19240195 2009
7
Correlation of gene and mediator expression with clinical endpoints in an acute interleukin-1beta-driven model of joint pathology. 61 54
19010066 2009
8
Break-through bleeding in relation to predicted factor VIII levels in patients receiving prophylactic treatment for severe hemophilia A. 54 61
19143924 2009
9
The combination of the biomarkers urinary C-terminal telopeptide of type II collagen, serum cartilage oligomeric matrix protein, and serum chondroitin sulfate 846 reflects cartilage damage in hemophilic arthropathy. 54 61
19116938 2009
10
[Knee ochronotic arthropathy and arthroscopic findings]. 61 54
19293619 2009
11
Prevention of arthropathy: may it be extrapolated from patients without inhibitors to patients with inhibitors? 54 61
19134030 2008
12
Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis. 61 54
18759291 2008
13
Economic evaluation of major knee surgery with recombinant activated factor VII in hemophilia patients with high titer inhibitors and advanced knee arthropathy: exploratory results via literature-based modeling. 61 54
18234151 2008
14
Joint diseases and matrix metalloproteinases: a role for MMP-13. 54 61
18289056 2008
15
[Genomic approaches to bone and joint diseases. Mutations of RANK, OPG and RANKL genes found in humans]. 61 54
18245890 2008
16
The role of VWF for the success of immune tolerance induction. 54 61
18549910 2008
17
The hand arthropathy of hereditary hemochromatosis is strongly associated with iron overload. 61 54
18061976 2008
18
WISP3 suppresses insulin-like growth factor signaling in human chondrocytes. 61 54
17942216 2007
19
Basic fibroblast growth factor activates the MAPK and NFkappaB pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes. 54 61
17724016 2007
20
Comparing prophylaxis with episodic treatment in haemophilia A: implications for clinical practice. 54 61
17685917 2007
21
Cuff tear arthropathy: evidence of functional variation in pyrophosphate metabolism genes. 54 61
17563703 2007
22
Effective therapy with anti-TNF-alpha in patients with psoriatic arthritis is associated with decreased levels of metalloproteinases and angiogenic cytokines in the sera and skin lesions. 54 61
17911474 2007
23
The anesthetic management of children with neonatal-onset multi-system inflammatory disease. 54 61
17646489 2007
24
Osteochondral repair in synovial joints. 61 54
17414953 2007
25
Mutant WISP3 triggers the phenotype shift of articular chondrocytes by promoting sensitivity to IGF-1 hypothesis of spondyloepiphyseal dysplasia tarda with progressive arthropathy (SEDT-PA). 61 54
17363178 2007
26
Stimulation of osteoclast formation by inflammatory synovial fluid. 61 54
16642388 2006
27
Ochronotic rheumatism in Algeria: clinical, radiological, biological and molecular studies--a case study of 14 patients in 11 families. 54 61
16085442 2006
28
HFE gene mutations are associated with osteoarthritis in the index or middle finger metacarpophalangeal joints. 54 61
16583477 2006
29
A homozygous mutation in the lamin A/C gene associated with a novel syndrome of arthropathy, tendinous calcinosis, and progeroid features. 54 61
16278265 2006
30
Synovial fluid macrophages are capable of osteoclast formation and resorption. 61 54
16278818 2006
31
HFE mutations in the pathobiology of hemophilic arthropathy. 54 61
15802547 2005
32
Analysis of cartilage oligomeric matrix protein (COMP) degradation and synthesis in equine joint disease. 54 61
15651731 2005
33
Simvastatin reduces MMP-3 level in interleukin 1beta stimulated human chondrocyte culture. 54 61
15194586 2004
34
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS): definition, semiology, prognosis, pathogenesis, treatment, and place relative to other periodic joint diseases. 61 54
15288852 2004
35
Coagulation factors with improved properties for hemophilia gene therapy. 61 54
15118934 2004
36
Serum human cartilage glycoprotein 39 as a marker of arthritis associated with inflammatory bowel disease. 54 61
14644865 2003
37
Effect of propolis on human cartilage and chondrocytes. 61 54
12818355 2003
38
The Hemophilia Utilization Group Study (HUGS): determinants of costs of care in persons with haemophilia A. 61 54
12694525 2003
39
Osteoclasts, pro-inflammatory cytokines, RANK-L and bone remodeling in rheumatoid arthritis. 54 61
12700082 2003
40
Elevated levels of synovial fluid antibodies reactive with the small proteoglycans biglycan and decorin in patients with rheumatoid arthritis or other joint diseases. 61 54
12649398 2003
41
Vitreoretinopathy with phalangeal epiphyseal dysplasia, a type II collagenopathy resulting from a novel mutation in the C-propeptide region of the molecule. 54 61
12205109 2002
42
Concentrations of cartilage oligomeric matrix protein in dogs with naturally developing and experimentally induced arthropathy. 61 54
11939326 2002
43
Hemophilic arthropathy. A scoring system for magnetic resonance imaging. 61 54
11960235 2002
44
Clinical significance of cytokine determination in synovial fluid. 54 61
11890208 2002
45
Persistence of parvovirus B19 DNA in synovium of patients with haemophilic arthritis. 61 54
11536251 2001
46
Arthropathy in hereditary hemochromatosis. 54 61
11148720 2001
47
Increased synovial fluid levels of interleukin-12, sCD25 and sTNF-RII/sTNF-RI ratio delineate a cytokine pattern characteristic of immune arthropathies. 54 61
11125312 2000
48
Synovial fluid matrix metalloproteinase-3 levels are increased in inflammatory arthritides whether erosive or not. 54 61
11136879 2000
49
Synovial hyperplasia in HTLV-I associated arthropathy is induced by tumor necrosis factor-alpha produced by HTLV-I infected CD68+ cells. 61 54
10782809 2000
50
Specific expression of interleukin-1 beta in temporomandibular joints with internal derangement: correlation with clinical findings. 61 54
10519747 1999
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Variations for Arthropathy

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Expression for Arthropathy

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Search GEO for disease gene expression data for Arthropathy.
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Pathways for Arthropathy

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Pathways related to Arthropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
IL-6 signaling pathway 1
Show member pathways
 11.59 TNFSF11 IL6 CRP
2
Microglia Activation During Neuroinflammation: Overview 64
Show member pathways
 11.56 TNF MMP2 IL6 ACAN
3
Pertussis 36
11.51 TNF NLRP3 IL6
4
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.41 TNF MMP2 IL6
5
Lung fibrosis 1
11.38 TNF MMP2 IL6
6
Photodynamic therapy-induced AP-1 survival signaling. 1
11.25 TNF MMP2 IL6
7
Malaria 36
11.2 TNF IL6 COMP
8
amb2 Integrin signaling 1
11.11 TNF MMP2 IL6
9
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
10.58 TNFSF11 TNFRSF11B TNF IL6
10
Overview of nanoparticle effects 1
10.41 TNF IL6 CRP
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GO Terms for Arthropathy

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Cellular components related to Arthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 TNFSF11 TNFRSF11B TNF PRG4 NLRP3 MMP2
2 collagen-containing extracellular matrix GO:0062023 9.65 PRG4 MMP2 F9 COMP ACAN
3 extracellular matrix GO:0031012 9.55 TNFRSF11B MMP2 COMP CCN6 ACAN
4 extracellular space GO:0005615 9.44 TNFSF11 TNFRSF11B TNF MMP2 MICA IL6
5 MHC class I protein complex GO:0042612 9.37 HFE B2M
6 HFE-transferrin receptor complex GO:1990712 9.32 HFE B2M

Biological processes related to Arthropathy according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.93 TNFSF11 TNF PRG4 MICA IL6 B2M
2 cytokine-mediated signaling pathway GO:0019221 9.89 TNFSF11 TNF MMP2 IL6 IL1RAPL2
3 skeletal system development GO:0001501 9.83 TNFRSF11B COMP ANKH ACAN
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 TNFSF11 TNF NLRP3 IL6
5 positive regulation of JNK cascade GO:0046330 9.78 TRPV4 TNFSF11 TNF
6 positive regulation of smooth muscle cell proliferation GO:0048661 9.75 TNF MMP2 IL6
7 positive regulation of gene expression GO:0010628 9.73 TRPV4 TNFSF11 TNF IL6 HFE CRP
8 defense response to Gram-positive bacterium GO:0050830 9.71 TNF NLRP3 IL6 CRP
9 positive regulation of neuroinflammatory response GO:0150078 9.61 TNF IL6
10 negative regulation of neurogenesis GO:0050768 9.61 TNF IL6 B2M
11 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent GO:0002486 9.6 MICA HFE
12 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.59 MICA HFE
13 cellular response to nicotine GO:0071316 9.58 TNF B2M
14 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.57 NLRP3 IL6
15 positive regulation of receptor binding GO:1900122 9.56 HFE B2M
16 negative regulation of receptor binding GO:1900121 9.55 HFE B2M
17 extracellular matrix organization GO:0030198 9.55 TNFRSF11B TNF MMP2 COMP ACAN
18 cellular response to iron ion GO:0071281 9.54 HFE B2M
19 regulation of iron ion transport GO:0034756 9.48 HFE B2M
20 positive regulation of transferrin receptor binding GO:1904437 9.37 HFE B2M
21 positive regulation of ferrous iron binding GO:1904434 9.32 HFE B2M
22 negative regulation of lipid storage GO:0010888 9.13 TNF IL6 CRP
23 acute-phase response GO:0006953 8.92 IL6 HFE F8 CRP

Molecular functions related to Arthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 TNFSF11 TNFRSF11B TNF IL6
2 identical protein binding GO:0042802 9.17 TRPV4 TNFSF11 TNF NLRP3 HGD CRP
3 beta-2-microglobulin binding GO:0030881 8.96 MICA HFE
Sources

Sources for Arthropathy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
22 G