Arthropathy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ART023 MIFTS: 68	Arthropathy Categories: Bone diseases
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Aliases & Classifications for Arthropathy

MalaCards integrated aliases for Arthropathy:

Name: Arthropathy ¹² ³⁰ ⁵⁶ ¹⁵ ⁷⁴

Joint Ankylosis of the Pelvic Region and Thigh ¹²

Ankylosis of Joint of Pelvic Region and Thigh ¹²

Joint Ankylosis of the Ankle and/or Foot ¹²

Ankylosis of Joint of Ankle and/or Foot ¹²

Joint Ankylosis of the Shoulder Region ¹²

Ankylosis of Joint of Shoulder Region ¹²

Joint Ankylosis of the Ankle and Foot ¹²

Arthropathy Associated with Infection ⁷⁴

Ankylosis of Joint of Multiple Sites ¹²

Ankylosis of Ankle and Foot Joint ¹²

Joint Ankylosis of the Lower Leg ¹²

Joint Ankylosis of the Upper Arm ¹²

Ankylosis of Joint of Lower Leg ¹²

Ankylosis of Joint of Upper Arm ¹²

Joint Ankylosis of the Forearm ¹²

Ankylosis of Joint of Forearm ¹²

Ankylosis of Lower Leg Joint ¹²

Ankylosis of Multiple Joints ¹²

Ankylosis of Upper Arm Joint ¹²

Joint Ankylosis of the Hand ¹²

Ankylosis of Forearm Joint ¹²

Ankylosis of Joint of Hand ¹²

Ankylosis of Hand Joint ¹²

Infectious Arthropathy ¹²

Joint Diseases ⁴⁵

Joint Disease ¹⁷

Classifications:

MalaCards categories:
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the musculoskeletal system and connective tissue

Infectious arthropathies

Inflammatory polyarthropathies

Arthropathies in other diseases classified elsewhere

Other joint disorders

Other joint disorders, not elsewhere classified

Joint disorder, unspecified

Other specified joint disorders

Other specific joint derangements

Joint derangement, unspecified

External Ids:

Disease Ontology ¹² DOID:381

ICD9CM ³⁶ 711 716.9 716.90 more

MeSH ⁴⁵ D007592

NCIt ⁵¹ C35760 C78402

SNOMED-CT ⁶⁹ 48548006 8316001 83486002

ICD10 ³⁴ M00-M02 M00-M03 M12.9 more

EFO ¹⁷ EFO_1000999

UMLS ⁷⁴ C0022408 C0157749

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Summaries for Arthropathy

Disease Ontology : ¹² A bone disease that is located in the joint.

MalaCards based summary : Arthropathy, also known as joint ankylosis of the pelvic region and thigh, is related to reactive arthritis and hemophilic arthropathy, and has symptoms including joint stiffness, arthralgia and back pain. An important gene associated with Arthropathy is PRG4 (Proteoglycan 4), and among its related pathways/superpathways are Overview of nanoparticle effects and Transcription_Role of VDR in regulation of genes involved in osteoporosis. The drugs Adalimumab and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and eye, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia : ⁷⁷ An arthropathy is a disease of a joint. Arthritis is a form of arthropathy that involves inflammation of... more...

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Related Diseases for Arthropathy

Diseases in the Arthropathy family:

Transient Arthropathy

Diseases related to Arthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 499)

#	Related Disease	Score	Top Affiliating Genes
1	reactive arthritis	32.9	COMP CRP TNF
2	hemophilic arthropathy	32.9	COMP HFE TNFRSF11B TNFSF11
3	osteoarthritis	32.4	ACAN COMP PRG4 TNF
4	psoriatic arthritis	31.9	COMP CRP MICA TNF TNFRSF11B TNFSF11
5	chondrocalcinosis	30.8	ANKH HFE TNFRSF11B
6	pericarditis	30.8	CRP PRG4 TNF
7	multicentric reticulohistiocytosis	30.7	TNFRSF11B TNFSF11
8	spondylitis	30.6	CRP MICA TNF
9	arthritis	30.4	ACAN ANKH MICA TNF TNFSF11
10	spondyloarthropathy 1	29.9	ANKH B2M CRP TNF TNFRSF11B
11	rheumatic disease	29.8	CRP TNF TNFRSF11B
12	rheumatoid arthritis	29.8	COMP CRP TNF TNFRSF11B TNFSF11
13	peritonitis	29.5	B2M CRP TNF
14	myeloma, multiple	29.5	B2M CRP TNF TNFRSF11B TNFSF11
15	uremia	29.4	B2M CRP TNFRSF11B
16	tenosynovitis	29.4	COMP CRP
17	familial mediterranean fever	29.4	CRP NLRP3 TNF
18	chronic meningitis	29.4	CRP NLRP3
19	meningitis	29.4	CRP NLRP3 TNF
20	synovitis	29.3	COMP CRP PRG4 TNF TNFRSF11B TNFSF11
21	bone disease	28.8	ACAN B2M TNF TNFRSF11B TNFSF11
22	bone inflammation disease	28.0	ACAN COMP CRP NLRP3 TNF TNFRSF11B
23	camptodactyly-arthropathy-coxa vara-pericarditis syndrome	12.7
24	multicentric osteolysis, nodulosis, and arthropathy	12.6
25	arthropathy, progressive pseudorheumatoid, of childhood	12.6
26	crystal arthropathies	12.6
27	digital arthropathy-brachydactyly, familial	12.5
28	neurogenic arthropathy	12.4
29	mseleni joint disease	12.4
30	behcet's syndrome arthropathy	12.2
31	handigodu joint disease	12.2
32	transient arthropathy	12.2
33	multicentric osteolysis-nodulosis-arthropathy spectrum	12.2
34	arthropathy, erosive	12.1
35	chondrocalcinosis 2	12.0
36	familial calcium pyrophosphate deposition	11.9
37	handigodu disease	11.9
38	joint disorders	11.8
39	gout	11.7
40	jaccoud's syndrome	11.6
41	hemochromatosis, type 2a	11.5
42	distal arthrogryposis	11.4
43	myhre syndrome	11.3
44	cinca syndrome	11.3
45	ankylosis	11.3
46	wild type abeta2m amyloidosis	11.3
47	hemochromatosis type 2	11.3
48	mandibuloacral dysplasia with type a lipodystrophy	11.3
49	winchester syndrome	11.2
50	mitochondrial dna depletion syndrome 6	11.1

Graphical network of the top 20 diseases related to Arthropathy:

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Symptoms & Phenotypes for Arthropathy

UMLS symptoms related to Arthropathy:

joint stiffness, arthralgia, back pain, sciatica, muscle cramp, metatarsalgia, joint symptom, musculoskeletal symptom, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm, other symptoms referable to joint, shoulder region, other symptoms referable to joint, upper arm, other symptoms referable to joint, forearm, other symptoms referable to joint, hand, other symptoms referable to joint, pelvic region and thigh, other symptoms referable to joint, lower leg, other symptoms referable to joint, ankle and foot, other symptoms referable to joint, other specified sites, other symptoms referable to joint, multiple sites, other symptoms referable to joint, site unspecified

MGI Mouse Phenotypes related to Arthropathy:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.21	ANKH B2M COMP CRP F8 F9
2	growth/size/body region	MP:0005378	10.17	ANKH B2M COMP HFE HGD MMP2
3	immune system	MP:0005387	10.17	ANKH B2M COMP CRP F8 F9
4	cardiovascular system	MP:0005385	10.16	ANKH B2M COMP CRP F9 MMP2
5	hematopoietic system	MP:0005397	10.14	ANKH B2M F8 F9 HFE MMP2
6	limbs/digits/tail	MP:0005371	9.86	ANKH COMP HFE NLRP3 TNF TNFRSF11B
7	liver/biliary system	MP:0005370	9.7	B2M F9 HFE HGD NLRP3 TNF
8	muscle	MP:0005369	9.5	ANKH COMP MMP2 TNF TNFSF11 TRPV4
9	skeleton	MP:0005390	9.32	ANKH COMP HFE HGD MMP2 NLRP3

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Drugs & Therapeutics for Arthropathy

Drugs for Arthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1023)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Adalimumab

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

331731-18-1

16219006

Etanercept

Approved, Investigational

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

185243-69-0

Hyaluronic acid

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

9004-61-9

53477741

Prednisone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

53-03-2

5865

Azithromycin

Approved

Phase 4,Phase 3

83905-01-5

447043 55185

Thrombin

Approved, Investigational

Phase 4,Not Applicable

Tranylcypromine

Approved, Investigational

Phase 4

155-09-9

441233

Rivaroxaban

Approved

Phase 4,Phase 2,Phase 3,Not Applicable

366789-02-8

Tranexamic Acid

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

1197-18-8

5526

Triamcinolone

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

124-94-7

31307

Celecoxib

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

169590-42-5

2662

Dalteparin

Approved

Phase 4,Phase 3

9005-49-6

Enoxaparin

Approved

Phase 4,Phase 3,Not Applicable

9005-49-6

772

Heparin

Approved, Investigational

Phase 4,Phase 3,Not Applicable

9005-49-6

46507594 772

Acetylcholine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

51-84-3

187

Diclofenac

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

15307-86-5

3033

Glucosamine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

3416-24-8

439213

Acetaminophen

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

103-90-2

1983

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

50-02-2

5743

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

1177-87-3

Lidocaine

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

137-58-6

3676

Ketorolac

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

74103-06-3, 66635-83-4

3826

Betamethasone

Approved, Vet_approved

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

378-44-9

9782

Iron

Approved, Experimental

Phase 4,Phase 1,Phase 2,Not Applicable

7439-89-6, 15438-31-0

27284 23925

Naproxen

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

22204-53-1

156391 1302

Esomeprazole

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

161796-78-7, 161973-10-0, 119141-88-7

9568614 4594

Spironolactone

Approved

Phase 4

1952-01-7, 52-01-7

5833

Ropivacaine

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

84057-95-4

175805 71273

Cimetidine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Not Applicable

51481-61-9

2756

Hyoscyamine

Approved

Phase 4,Not Applicable

101-31-5

64692

Norepinephrine

Approved

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

51-41-2

439260

Levomilnacipran

Approved, Investigational

Phase 4

96847-54-0

Milnacipran

Approved, Investigational

Phase 4

92623-85-3

65833

Bupivacaine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable

38396-39-3, 2180-92-9

2474

leucovorin

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

58-05-9

143 6006

Methotrexate

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

1959-05-2, 59-05-2

126941

Abatacept

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

332348-12-6

10237

Sulfasalazine

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

599-79-1

5359476 5353980

Hydroxychloroquine

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

118-42-3

3652

Leflunomide

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

75706-12-6

3899

Infliximab

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

170277-31-3

Certolizumab pegol

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

428863-50-7

Etoricoxib

Approved, Investigational

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

202409-33-4

123619

rituximab

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

174722-31-7

10201696

Methylprednisolone hemisuccinate

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

2921-57-5

Prednisolone phosphate

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

302-25-0

Ethanol

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

64-17-5

702

Naltrexone

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Not Applicable

16590-41-3

5360515

Prednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

50-24-8

5755

Methylprednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

83-43-2

6741

Interventional clinical trials:

(show top 50) (show all 8009)

#	Name	Status	NCT ID	Phase	Drugs
1	Study of Adalimumab to Lower Cardiovascular Risk in RA Patients With Well Controlled Joint Disease	Unknown status	NCT01893996	Phase 4	Adalimumab;Placebo
2	Targeting Synovitis in Early Rheumatoid Arthritis	Unknown status	NCT00920478	Phase 4
3	Hyaluronan Versus NaCl 20 Ml Versus Placebo in Knee Osteoarthritis	Unknown status	NCT00144820	Phase 4	Injection of Hyaluronan or Saline
4	A Clinical Phenotype Based Individualized Prophylaxis in Chinese Hemophilia A Children	Unknown status	NCT02999308	Phase 4
5	The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease	Unknown status	NCT01469702	Phase 4	prednison and azithromycin;prednison, azithromycin;prednison, Azenil
6	The Effect of Biannual Monitoring With Magnetic Resonance Imaging (MRI), X-ray, or Usual Care on Treatment for Inflammatory Arthritis	Unknown status	NCT00808496	Phase 4
7	Subclinical Joint Bleeding in Irish Adults With Severe Haemophilia A on Personalised Prophylaxis Regimens	Unknown status	NCT02314325	Phase 4	ADVATE [Antihemophilic Factor (Recombinant)];ADVATE [Antihemophilic Factor (Recombinant)]
8	Birmingham Hip Resurfacing (BHR) Study: Implantation of a Hip Resurfacing Endoprosthesis	Unknown status	NCT00180206	Phase 4
9	W-Shaped Acetabular Angular Plate (WAAP) Versus Reconstruction Plate	Unknown status	NCT02327949	Phase 4
10	Evicel Study on the Peri-operative Bleeding in Total Knee Prothesis Surgery	Unknown status	NCT00983112	Phase 4	Human Fibrinogen and human thrombin (Evicel);Sodium Chlorure (Physiological saline)
11	Combined Topical Tranexamic Acid With Floseal® in Total Knee Arthroplasty	Unknown status	NCT03328832	Phase 4	Topical tranexamic acid;Floseal®;rivaroxaban (10mg)
12	Outcomes of Injections in Patients Waiting for Total Knee Replacement	Unknown status	NCT03090698	Phase 4	Hylan G-F 20;Triamcinolone
13	The Study to Evaluate Efficacy and Safety of Celecoxib Capsule in Hand Osteoarthritis Patients	Unknown status	NCT03067194	Phase 4	Celecoxib 100 MG;Celecoxib 200mg
14	Additional Effects of Triamcinolone to Hyaluronic Acid on Knee Osteoarthritis	Unknown status	NCT02949466	Phase 4	Triamcinolone
15	Topical Tranexamic Acid and Floseal® in Total Knee Arthroplasty	Unknown status	NCT02865174	Phase 4	Topical tranexamic acid;Floseal®;Enoxaparin
16	Influence of Perception of Patients Suffering of Knee Osteoarthritis Regarding Effectiveness of Intra-articular Injection	Unknown status	NCT02835521	Phase 4	Joint injection with triamcinolone hexacetonide
17	Intra-articular Botox Type A Versus Corticosteroids in Knee Osteoarthritis	Unknown status	NCT02829281	Phase 4	Botulinum Toxin Type A;Triamcinolone hexacetonide;Saline
18	Clinical Study of Artz in the Treatment of Knee Osteoarthritis	Unknown status	NCT02826031	Phase 4	Sodium Hyaluronate Injection;DICL-SR
19	Primary Care Study With Chondroitin Sulfate and Glucosamine Hydrochloride in Hand Osteoarhritis	Unknown status	NCT02823548	Phase 4	Droglican;Placebo
20	Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN	Unknown status	NCT02821468	Phase 4	Droglican;Paracetamol or oral NSAIDs excluding COX2 inhibitors
21	Effects of Perioperative Intravenous Dexamethasone on the Severity of Persistent Postsurgical Pain After Total Knee Arthroplasty : A Prospective, Randomized, Double-blind, Placebo-controlled Trial	Unknown status	NCT02760459	Phase 4	Dexamethasone;Normal saline solution
22	Assessment of a Knee Brace in Patients With Osteoarthritis	Unknown status	NCT02706106	Phase 4
23	Effectiveness of Trapeziometacarpal Splint	Unknown status	NCT02635932	Phase 4
24	26 Week Open Label Study Evaluating Single IA Injection of DUROLANE SJ for Treatment of Osteoarthritis Pain of the Ankle	Unknown status	NCT02627859	Phase 4
25	Effects of Hyaluronic Acid vs. Hyaluronic Acid on Knee Osteoarthritis	Unknown status	NCT02625727	Phase 4
26	Comparing Intra-articular Corticosteroid to Intra-articular Ketorolac Knee Injections	Unknown status	NCT02612272	Phase 4	Ketorolac;Betamethasone
27	Intravenous Iron Sucrose in Arthroplasty	Unknown status	NCT02544828	Phase 4	Iron Sucrose 200mg;placebo
28	The Post-marketing Surveillance to Evaluate the Efficacy of CHONDRON (Autologous Cultured Chondrocyte) by Arthroscopy	Unknown status	NCT02539069	Phase 4
29	The Post-marketing Surveillance to Evaluate the Efficacy and Safety of a CHONDRON (Autologous Cultured Chondrocyte)	Unknown status	NCT02539056	Phase 4
30	Multi-center Clinical Study of Guli Capsules in the Treatment of Knee Osteoarthritis	Unknown status	NCT02484508	Phase 4	Guli capsule;Kangguzengsheng capsule
31	Comparison of Topical and Infusion Tranexamic Acid After Total Knee Arthroplasty	Unknown status	NCT02453802	Phase 4	Tranexamic Acid 5%,5ml/amp;Tranexamic Acid 5%,5ml/amp;rivaroxaban (10mg);0.9% Normal Saline;0.9% Normal Saline
32	Validation of a Stress Device for the Knee	Unknown status	NCT02444663	Phase 4
33	Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis	Unknown status	NCT02355236	Phase 4	Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
34	Medical Chitosan or Sodium Hyaluronate for Knee Osteoarthritis (CHOOSE)	Unknown status	NCT02323451	Phase 4	Sodium Hyaluronate Injection
35	Tranexamic Acid in Knee Joint Surgery	Unknown status	NCT02278263	Phase 4	Tranexamic Acid;Normal saline (0.9% NaCl)
36	Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty	Unknown status	NCT02152917	Phase 4	Tranexamic acid;Floseal®
37	Intraarticular Xylitol Injections for Knee Osteoarthritis	Unknown status	NCT02104596	Phase 4
38	The Effect of Spironolactone on Pain in Older People With Osteoarthritis	Unknown status	NCT02046668	Phase 4	spironolactone
39	Outcome Comparison of Allograft and Synthetic Bone Substitute in High Tibial Osteotomy	Unknown status	NCT02000297	Phase 4
40	A Phase 4 Study of Imrecoxib in Treatment of Knee Osteoarthritis	Unknown status	NCT01985165	Phase 4	Imrecoxib
41	Comparison of Femoral Nerve Catheter and Adductor Canal Block With Steroid Adjuvant in Total Knee Replacement (TKR)	Unknown status	NCT01973530	Phase 4
42	Reinflation After Early Tourniquet Release in Total Knee Arthroplasty	Unknown status	NCT01832272	Phase 4
43	Hip Viscosupplementation: What is the Best Dosage?	Unknown status	NCT01810809	Phase 4	1 ampoule of Hylan GF-20;2 ampoules of Hylan GF-20;3 ampoules of Hylan GF-20
44	Bone Forming at Prosthetic Surfaces. Fingerprint2	Unknown status	NCT01623687	Phase 4
45	RSA Study Using Two Types of Uncemented Acetabular Components and the Uncemented HA Coated Symax Stem	Unknown status	NCT01618084	Phase 4
46	Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis	Unknown status	NCT01329406	Phase 4	Milnacipran;Placebo
47	Chondroitin Sulphate Treatment Efficacy in Rhizarthrosis.	Unknown status	NCT01233739	Phase 4	Chondroitin sulfate;Placebo
48	Assessment of the Effects of Chondroitin Sulphate in Patients With Knee Osteoarthritis With Functional Magnetic Resonance Imaging (fMRI)	Unknown status	NCT01226615	Phase 4	Chondroitin sulphate (Condrosan®);Placebo
49	Prophecy Guide Outcomes in Total Knee Replacement Surgery	Unknown status	NCT01163708	Phase 4
50	Close Kinect Chain Exercise With Kinesio Taping in the Management of Patellofemoral Pain Syndrome	Unknown status	NCT02241148	Phase 4	Acetaminophen 500mg

Search NIH Clinical Center for Arthropathy

Cochrane evidence based reviews: joint diseases

Sources

Genetic Tests for Arthropathy

Genetic tests related to Arthropathy:

#	Genetic test	Affiliating Genes
1	Arthropathy ³⁰

Sources

Anatomical Context for Arthropathy

MalaCards organs/tissues related to Arthropathy:

⁴²

Bone, Testes, Eye, Bone Marrow, Breast, Heart, T Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Arthropathy:

²⁰

The Joint

Sources

Publications for Arthropathy

Articles related to Arthropathy:

(show top 50) (show all 2407)

#	Title	Authors	Year
1	Arthropathy in acromegaly: a questionnaire-based estimation of motor disability and its relation with quality of life and work productivity. ( 31032537 )	Fatti LM...Study Group on Motor Disability in Acromegaly of the Italian Society of Endocrinology	2019
2	Massive acromio-clavicular joint ganglion cyst associated with cuff tear arthropathy and acromioclavicular joint arthritis with normal functional shoulder-A case report. ( 31061582 )	Purohit S...Marathe N	2019
3	MR neurography showed brachial plexus abnormalities in syringomyelia with shoulder Charcot arthropathy: a case report. ( 30892961 )	Chen K...Li T	2019
4	Risks and patient outcomes of surgical intervention for hemophilic arthropathy. ( 30929534 )	Rodriguez-Merchan EC	2019
5	Overlapping features of rapidly progressive osteoarthrosis and Charcot arthropathy. ( 30936675 )	Sono T...James AW	2019
6	Using synovial volume measurement by MRI to evaluate the effect of 32P Radiation synovectomy on hemophilic arthropathy patients. ( 30958324 )	Dou Y...Ge Y	2019
7	Monitoring Bone Health in Children with Hemophilic Arthropathy: Where Do We Stand? ( 30972699 )	Goyal A...Khadgawat R	2019
8	Chronic postrheumatic fever arthropathy. ( 30978163 )	Moorthy N...Ananthakrishna R	2019
9	Commentary on the paper: "Hindfoot malalignment in adults with haemophilic ankle arthropathy: The importance of early detection and orthotic treatment": Authored by: De la Corte-Rodriguez, Rodriguez-Merchan, Alvarez-Roman, Martin-Salces, Jimenez-Yuste. ( 30994252 )	Barg A...International WBCT Society	2019
10	Low-dose computed tomography as diagnostic tool in calcium pyrophosphate deposition disease arthropathy: focus on ligamentous calcifications of the wrist. ( 31025927 )	Ziegeler K...Hermann KGA	2019
11	Familial Mediterranean Fever Gene Mutations and Gout as an Auto-Inflammatory Arthropathy. ( 31097862 )	Salehzadeh F...Enteshary A	2019
12	Imaging of Progressive Neuropathic Arthropathy of the Shoulder. ( 29979203 )	Hwang G...Lee SW	2019
13	Subgroups of patients with osteoarthritis and medial meniscus tear or crystal arthropathy benefit from arthroscopic treatment. ( 30128683 )	Karpinski K...Petersen W	2019
14	Ultrasound-Guided Prolotherapy for Acromial Enthesopathy and Acromioclavicular Joint Arthropathy: A Single-Arm Prospective Study. ( 30171616 )	Hsieh PC...Lin YH	2019
15	Models of arthropathy: what can we learn from them to improve patient care? ( 30239955 )	Pulles AE...van Vulpen LFD	2019
16	Glenohumeral Dislocation Arthropathy: Etiology, Diagnosis, and Management. ( 30278009 )	Vezeridis PS...Petrigliano FA	2019
17	Corrigendum to "Primary Total Knee Arthroplasty in Patients With Neuropathic (Charcot) Arthropathy: Contemporary Results" [Journal of Arthroplasty 33 (2018) 2815-2820]. ( 30293755 )	Tibbo ME...Abdel MP	2019
18	Subclinical crystal arthropathy: a silent contributor to inflammation and functional disability in knees with osteoarthritis-an ultrasound study. ( 30327988 )	Mohammed RHA...Di Matteo A	2019
19	Assessment of tensile mechanical properties of the Achilles tendon in adult patients with haemophilic arthropathy. Reproducibility study. ( 30375147 )	Cruz-Montecinos C...Maas H	2019
20	Clinical effectiveness and safety of the extended humeral head arthroplasty for selected patients with rotator cuff tear arthropathy. ( 30392935 )	Matsen FA...Neradilek MB	2019
21	Clinicopathological case: rapid cognitive decline and myoclonus associated with fever, arthropathy and scleritis. ( 30425126 )	Ellis RJB...Davenport R	2019
22	Joint status in Spanish haemophilia B patients assessed using the Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) score. ( 30444298 )	Jim?nez-Yuste V...Kim HK	2019
23	Charcot spinal arthropathy presenting as adjacent segment disease after lumbar spinal fusion surgery in Parkinson's disease: A case report. ( 30446371 )	Miura K...Yamazaki M	2019
24	Glenoid morphology is associated with the development of instability arthropathy. ( 30509607 )	Haas M...Moroder P	2019
25	Bleed volume of experimental knee haemarthrosis correlates with the subsequent degree of haemophilic arthropathy. ( 30648774 )	V?ls KK...Petersen M	2019
26	Hindfoot malalignment in adults with haemophilic ankle arthropathy: The importance of early detection and orthotic treatment. ( 30664313 )	De la Corte-Rodriguez H...Jimenez-Yuste V	2019
27	Poor patient-reported outcome after shoulder replacement in young patients with cuff-tear arthropathy: a matched-pair analysis from the Danish Shoulder Arthroplasty Registry. ( 30669910 )	Ammitzboell M...Rasmussen JV	2019
28	Serum Sclerostin Level and Bone Mineral Density in Pediatric Hemophilic Arthropathy. ( 30671760 )	El-Mikkawy DME...Samaha D	2019
29	Arthropathy and Cutaneous Eruption in a Patient With Cystic Fibrosis. ( 30673074 )	Luu LA...Zlotoff BJ	2019
30	Clinical manifestations and risk factors of arthropathy in cystic fibrosis. ( 30704701 )	Roehmel JF...Schwarz C	2019
31	Assessment of haemophilic arthropathy through balance analysis: a promising tool. ( 30714398 )	Garc?a-Mass? X...Gonzalez LM	2019
32	The Prevalence of Asymptomatic Cervical and Lumbar Facet Arthropathy: A Computed Tomography Study. ( 30744307 )	Kim JH...Kim SY	2019
33	Neuromuscular control during gait in people with haemophilic arthropathy. ( 30748060 )	Cruz-Montecinos C...Maas H	2019
34	Syphilis with Charcot arthropathy: a case report. ( 30758895 )	Wang M...Li L	2019
35	Can a functional difference be detected in reverse arthroplasty with 135° versus 155° prosthesis for the treatment of rotator cuff arthropathy: a prospective randomized study. ( 30773441 )	Gobezie R...Denard PJ	2019
36	Facet arthropathy evaluation: CT or MRI? ( 30796571 )	Berg L...Espeland A	2019
37	Humeral head histopathological changes in cuff tear arthropathy. ( 30798768 )	Toma T...Kanaya F	2019
38	Neuropathic arthropathy of the shoulder joint caused by syringomyelia: report of a rare case. ( 30850574 )	Choudhury P...Chauhan V	2019
39	Pressure distribution under the contralateral limb in Charcot arthropathy with different walking speeds. ( 30851651 )	Motawea M...Armstrong DG	2019
40	Long-term results of total knee arthroplasty in hemophilic arthropathy. ( 30852987 )	Santos Silva M...Costa E Castro J	2019
41	An exploratory comparison of single intra-articular injection of platelet-rich plasma vs hyaluronic acid in treatment of haemophilic arthropathy of the knee. ( 30866117 )	Li TY...Chen YC	2019
42	Outpatient treatment for haemophilic arthropathy with radiosynovectomy: Radiation dose to family members. ( 30866133 )	Oliveira S...de Souza SAL	2019
43	Anterior osteophyte resection of the ankle joint to increase range of motion in haemophilic ankle arthropathy. ( 30866148 )	Yoo MC...Ahn J	2019
44	Destructive arthropathy of the shoulder complicating a cervical ependymoma. ( 30890366 )	Alaya Z	2019
45	Injury to the axillary and suprascapular nerves in rotator cuff arthropathy and after reverse shoulder arthroplasty: a prospective electromyographic analysis. ( 29475786 )	Lopiz Y...Marco F	2018
46	Physiotherapist inter-rater reliability of the Haemophilia Early Arthropathy Detection with Ultrasound protocol. ( 29493853 )	Stephensen D...Wells A	2018
47	Beekeeper' arthropathy. ( 29530760 )	Diez Morrondo C...Garc?a Arias M	2018
48	Prevalence of Charcot Arthropathy in Type 2 Diabetes Patients Aged over 50 Years with Severe Peripheral Neuropathy: A Retrospective Study in a Tertiary Care South Indian Hospital. ( 29535947 )	Salini D...Praveen VP	2018
49	Safety of fascial therapy in adult patients with hemophilic arthropathy of ankle. A cohort study. ( 29550698 )	Donoso-?beda E...Cuesta-Barriuso R	2018
50	Assessment of passive musculoarticular ankle stiffness in children, adolescents and young adults with haemophilic ankle arthropathy. ( 29600577 )	Lobet S...Deschamps K	2018

Sources

Genes for Arthropathy

Genes related to Arthropathy (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	PRG4	Proteoglycan 4	Protein Coding	61.48	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Gene name Summaries Variants (show sections)
2	MMP2	Matrix Metallopeptidase 2	Protein Coding	51.33	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
3	CCN6	Cellular Communication Network Factor 6	Protein Coding	40.35	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders Publications Variants (show sections)	17942216 17363178
4	TRPV4	Transient Receptor Potential Cation Channel Subfamily V Member 4	Protein Coding	39.64	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
5	HGD	Homogentisate 1,2-Dioxygenase	Protein Coding	32.3	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	19293619 16085442 15529343
6	ANKH	ANKH Inorganic Pyrophosphate Transport Regulator	Protein Coding	32.02	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	17563703 12297987 9635372
7	B2M	Beta-2-Microglobulin	Protein Coding	31.4	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	7653483 8314633 8302409 (more) 8024566 2047516 7895398 8643171 7483518 2267282 2183807 1596709 10077983 8835497 9125253 1857788
8	F8	Coagulation Factor VIII	Protein Coding	30.97	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	17685917 11960235 18234151 (more) 19943875 19134030 19143924 18549910 9264782 12694525 15118934
9	HFE	Homeostatic Iron Regulator	Protein Coding	30.85	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	16583477 19942354 11148720 (more) 17373275 15802547
10	TNF	Tumor Necrosis Factor	Protein Coding	30.78	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders (show sections)	7848311 15320917 18726101 (more) 11125312 20038753 1616355 8868110 18352852 18565300 19299722 19706231 7848304 9058659 7902093 18208824 17414953 16684368 15288852 12920692 11560279 1700673 20035687 18713230 17644391 16688934 10219896 18759291 17603697 17109564 8040729 9790994 17911474 12463463 12269994 11556521 10782809 10064394 11890208 12662147 12794844 15009298 15627075 16278818 17009259
11	COMP	Cartilage Oligomeric Matrix Protein	Protein Coding	29.42	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	11939326 9143347 15651731 (more) 11237659 19116938 11063004 19877068 10661386
12	CRP	C-Reactive Protein	Protein Coding	29.09	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	1575582 1704698 12810432 (more) 10986307 17067658 16688934 9972954 11727841 7848311 15308517
13	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	29.03	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	17646489
14	MICA	MHC Class I Polypeptide-Related Sequence A	Protein Coding	28.4	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
15	F9	Coagulation Factor IX	Protein Coding	28.17	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	19134030 15118934
16	TNFSF11	TNF Superfamily Member 11	Protein Coding	26.09	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	20513175 12700082 16278818 (more) 16642388 18245890
17	TNFRSF11B	TNF Receptor Superfamily Member 11b	Protein Coding	24.64	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	20513175 18245890
18	ACAN	Aggrecan	Protein Coding	23.11	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
19	ZMPSTE24	Zinc Metallopeptidase STE24	Protein Coding	22.4	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	16278265

Sources

Variations for Arthropathy

Sources

Expression for Arthropathy

Search GEO for disease gene expression data for Arthropathy.

Sources

Pathways for Arthropathy

Pathways related to Arthropathy according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Overview of nanoparticle effects ¹	10.54	CRP TNF
2	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²³	10.45	TNF TNFRSF11B TNFSF11
3	Osteoclast Signaling ¹	10.36	TNFRSF11B TNFSF11
4	Osteoblast Signaling ¹	10.1	TNFRSF11B TNFSF11

Sources

GO Terms for Arthropathy

Cellular components related to Arthropathy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.77	ACAN B2M CCN6 COMP CRP F8
2	collagen-containing extracellular matrix	GO:0062023	9.67	ACAN COMP MMP2 PRG4
3	extracellular matrix	GO:0031012	9.55	ACAN CCN6 COMP MMP2 TNFRSF11B
4	extracellular space	GO:0005615	9.4	B2M CCN6 COMP CRP F8 F9
5	MHC class I protein complex	GO:0042612	9.32	B2M HFE
6	HFE-transferrin receptor complex	GO:1990712	9.26	B2M HFE

Biological processes related to Arthropathy according to GeneCards Suite gene sharing:

(show all 20)

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix organization	GO:0030198	9.78	ACAN COMP TNF TNFRSF11B
2	animal organ morphogenesis	GO:0009887	9.77	COMP TNF TNFSF11
3	defense response to Gram-positive bacterium	GO:0050830	9.73	CRP NLRP3 TNF
4	positive regulation of JNK cascade	GO:0046330	9.71	TNF TNFSF11 TRPV4
5	tumor necrosis factor-mediated signaling pathway	GO:0033209	9.67	TNF TNFRSF11B TNFSF11
6	skeletal system development	GO:0001501	9.67	ACAN ANKH COMP TNFRSF11B
7	immune response	GO:0006955	9.65	B2M MICA PRG4 TNF TNFSF11
8	blood coagulation, intrinsic pathway	GO:0007597	9.58	F8 F9
9	regulation of osteoclast differentiation	GO:0045670	9.57	TNF TNFSF11
10	growth plate cartilage development	GO:0003417	9.52	COMP ZMPSTE24
11	negative regulation of lipid storage	GO:0010888	9.51	CRP TNF
12	acute-phase response	GO:0006953	9.5	CRP F8 HFE
13	cellular response to iron ion	GO:0071281	9.46	B2M HFE
14	negative regulation of receptor binding	GO:1900121	9.43	B2M HFE
15	positive regulation of receptor binding	GO:1900122	9.4	B2M HFE
16	T cell mediated cytotoxicity	GO:0001913	9.28	MICA
17	susceptibility to natural killer cell mediated cytotoxicity	GO:0042271	9.25	MICA
18	positive regulation of ferrous iron binding	GO:1904434	9.16	B2M HFE
19	positive regulation of gene expression	GO:0010628	9.1	CRP HFE TNF TNFSF11 TRPV4 ZMPSTE24
20	positive regulation of transferrin receptor binding	GO:1904437	8.96	B2M HFE

Molecular functions related to Arthropathy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.8	B2M CRP HGD NLRP3 TNF TRPV4
2	extracellular matrix structural constituent conferring compression resistance	GO:0030021	9.26	ACAN PRG4
3	natural killer cell lectin-like receptor binding	GO:0046703	8.65	MICA
4	beta-2-microglobulin binding	GO:0030881	8.62	HFE MICA
5	protein binding	GO:0005515	10.06	ACAN B2M COMP CRP F8 F9

Sources

Sources for Arthropathy

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia