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MCID: ART023
MIFTS: 62

Arthropathy

Categories: Bone diseases
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Aliases & Classifications for Arthropathy

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MalaCards integrated aliases for Arthropathy:

Name: Arthropathy 11 28 53 14 36 71 75
Joint Ankylosis of the Pelvic Region and Thigh 11
Ankylosis of Joint of Pelvic Region and Thigh 11
Joint Ankylosis of the Ankle and/or Foot 11
Ankylosis of Joint of Ankle and/or Foot 11
Joint Ankylosis of the Shoulder Region 11
Ankylosis of Joint of Shoulder Region 11
Joint Ankylosis of the Ankle and Foot 11
Arthropathy Associated with Infection 71
Ankylosis of Joint of Multiple Sites 11
Ankylosis of Ankle and Foot Joint 11
Joint Ankylosis of the Lower Leg 11
Joint Ankylosis of the Upper Arm 11
Ankylosis of Joint of Lower Leg 11
Ankylosis of Joint of Upper Arm 11
Joint Ankylosis of the Forearm 11
Ankylosis of Joint of Forearm 11
Ankylosis of Lower Leg Joint 11
Ankylosis of Multiple Joints 11
Ankylosis of Upper Arm Joint 11
Joint Ankylosis of the Hand 11
Ankylosis of Forearm Joint 11
Ankylosis of Joint of Hand 11
Ankylosis of Hand Joint 11
Infectious Arthropathy 11
Joint Diseases 43
Joint Disease 16

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)
ICD10: 31
ICD11: 33


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Summaries for Arthropathy

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Disease Ontology: 11 A bone disease that is located in the joint.

MalaCards based summary: Arthropathy, also known as joint ankylosis of the pelvic region and thigh, is related to familial calcium pyrophosphate deposition and reactive arthritis, and has symptoms including joint stiffness, back pain and arthralgia. An important gene associated with Arthropathy is PRG4 (Proteoglycan 4), and among its related pathways/superpathways are Mesenchymal Stem Cells and Lineage-specific Markers and Spinal cord injury. The drugs Hyaluronic acid and Propofol have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and bone marrow, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia: 75 An arthropathy is a disease of a... more...
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Related Diseases for Arthropathy

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Diseases in the Arthropathy family:

Transient Arthropathy

Diseases related to Arthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1216)
# Related Disease Score Top Affiliating Genes
1 familial calcium pyrophosphate deposition 32.5 TNFRSF11B ANKH
2 reactive arthritis 32.4 TNF CRP COMP
3 osteoarthritis 32.3 TNFSF11 TNFRSF11B TNF PRG4 IL6 CRP
4 psoriatic arthritis 32.3 TNFSF11 TNFRSF11B TNF MMP2 MICA IL6
5 gout 32.3 TNF NLRP3 IL6 CRP
6 pseudoachondroplasia 31.9 COMP COL2A1 ACAN
7 chondrocalcinosis 31.9 TNFRSF11B NLRP3 HFE CRP ANKH
8 ankylosis 31.8 TNFSF11 TNFRSF11B TNF CRP ANKH
9 coxa vara 31.2 PRG4 COL2A1
10 spondyloarthropathy 1 31.2 TNFSF11 TNFRSF11B TNF IL6 CRP ANKH
11 amyloidosis 31.1 TNF NLRP3 IL6 CRP B2M
12 pericarditis 31.1 TNF PRG4 IL6 CRP
13 synovitis 31.0 TNFSF11 TNFRSF11B TNF PRG4 IL6 CRP
14 spondylitis 31.0 TNFSF11 TNF MICA IL6 CRP
15 tenosynovitis 31.0 TNF IL6 CRP
16 carpal tunnel syndrome 31.0 IL6 COMP B2M ACAN
17 avascular necrosis 30.9 TRPV4 COL2A1
18 exanthem 30.9 TNF NLRP3 IL6 CRP
19 septic arthritis 30.8 TNFSF11 TNF IL6 CRP ACAN
20 syphilis 30.8 TNF CRP B2M
21 osteomyelitis 30.8 TNFSF11 TNF NLRP3 IL6 CRP
22 alcohol use disorder 30.7 TNF IL6 HFE CRP
23 bowel dysfunction 30.7 TNF IL6 CRP
24 peripheral nervous system disease 30.7 TRPV4 TNF MMP2 IL6 HFE CRP
25 bursitis 30.7 TNF IL6 CRP
26 cartilage disease 30.6 TNF PRG4 IL6 CRP COMP COL2A1
27 hemophilia b 30.6 TNFRSF11B F9 F8
28 thyroiditis 30.6 TNF IL6 CRP
29 periostitis 30.6 TNFRSF11B TNF CRP
30 hyperostosis 30.6 TNFRSF11B MMP2 ANKH
31 radiculopathy 30.6 IL6 CRP ACAN
32 spinal stenosis 30.5 MMP2 COL2A1 ACAN
33 behcet syndrome 30.5 TNF NLRP3 IL6 CRP
34 spondylarthropathy 30.5 TNF CRP B2M
35 spondylosis 30.5 TNF IL6 CRP ACAN
36 spondyloarthropathy 30.5 TNFSF11 TNF IL6 CRP B2M ACAN
37 type 1 diabetes mellitus 30.5 TNFSF11 TNFRSF11B TNF MICA IL6 B2M
38 crohn's disease 30.5 TNF NLRP3 IL6 CRP
39 anterior uveitis 30.5 TNF IL6 CRP
40 atherosclerosis susceptibility 30.5 TNF MMP2 IL6 CRP
41 brucellosis 30.5 TNF NLRP3 IL6 CRP
42 erythema nodosum 30.5 TNF IL6 CRP
43 cystic fibrosis 30.5 TRPV4 TNFRSF11B TNF NLRP3 IL6 HFE
44 chikungunya 30.4 TNF IL6 CRP
45 degenerative disc disease 30.4 TNF COL2A1 ACAN
46 familial mediterranean fever 30.4 TNF NLRP3 IL6 CRP
47 polyarteritis nodosa 30.4 TNF IL6 CRP
48 chronic kidney disease 30.4 TNFSF11 TNFRSF11B TNF IL6 CRP B2M
49 enchondromatosis, multiple, ollier type 30.4 TNFSF11 COL2A1 ACAN
50 temporomandibular joint anomaly 30.4 TNFSF11 TNFRSF11B

Graphical network of the top 20 diseases related to Arthropathy:



Diseases related to Arthropathy
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Symptoms & Phenotypes for Arthropathy

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UMLS symptoms related to Arthropathy:


joint stiffness; back pain; arthralgia; sciatica; muscle cramp; metatarsalgia; joint symptom; musculoskeletal symptom; other symptoms referable to joint; stiffness of joint, not elsewhere classified in icd10cm; other symptoms referable to joint, shoulder region; other symptoms referable to joint, upper arm; other symptoms referable to joint, forearm; other symptoms referable to joint, hand; other symptoms referable to joint, pelvic region and thigh; other symptoms referable to joint, lower leg; other symptoms referable to joint, ankle and foot; other symptoms referable to joint, other specified sites; other symptoms referable to joint, multiple sites; other symptoms referable to joint, site unspecified

GenomeRNAi Phenotypes related to Arthropathy according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.17 ACAN ANKH B2M CCN6 COL2A1 COMP
2 no effect GR00402-S-2 10.17 ACAN ANKH B2M CCN6 COL2A1 CRP

MGI Mouse Phenotypes related to Arthropathy:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.41 ACAN ANKH B2M COL2A1 COMP CRP
2 growth/size/body region MP:0005378 10.28 ACAN ANKH B2M COL2A1 COMP HFE
3 immune system MP:0005387 10.22 ACAN ANKH B2M COL2A1 COMP CRP
4 limbs/digits/tail MP:0005371 10.18 ACAN ANKH COL2A1 COMP HFE NLRP3
5 cardiovascular system MP:0005385 10.18 ACAN ANKH B2M COL2A1 COMP CRP
6 liver/biliary system MP:0005370 10.15 ACAN B2M COL2A1 F9 HFE HGD
7 muscle MP:0005369 10.11 ACAN ANKH COMP IL6 MMP2 TNF
8 neoplasm MP:0002006 10.07 ACAN B2M CCN6 IL6 MMP2 TNF
9 digestive/alimentary MP:0005381 10.01 ACAN B2M COL2A1 HFE IL6 MMP2
10 skeleton MP:0005390 9.97 ACAN ANKH COL2A1 COMP HFE HGD
11 respiratory system MP:0005388 9.86 ACAN ANKH COL2A1 IL6 MMP2 TNF
12 mortality/aging MP:0010768 9.8 ACAN ANKH B2M COL2A1 F8 F9
13 integument MP:0010771 9.32 B2M CCN6 IL6 MMP2 NLRP3 PRG4
Sources

Drugs & Therapeutics for Arthropathy

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Drugs for Arthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 299)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3
Mepivacaine Approved, Vet_approved Phase 4 96-88-8, 1722-62-9 4062
4
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
5
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
6
Vecuronium Approved, Investigational Phase 4 50700-72-6, 86029-43-8 39765 39764
7
Tacrine Approved, Investigational, Withdrawn Phase 4 321-64-2 1935
8
Prilocaine Approved Phase 4 721-50-6 4906
9
Remifentanil Approved Phase 4 132875-61-7 60815
10
Adalimumab Approved, Experimental Phase 4 331731-18-1
11
Duloxetine Approved Phase 4 136434-34-9, 116539-59-4 60835
12
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
13
Norepinephrine Approved Phase 4 51-41-2 439260
14
Diclofenac Approved, Vet_approved Phase 4 15307-86-5, 15307-79-6 3033
15
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
16
Metamizole Approved, Investigational, Withdrawn Phase 4 50567-35-6 3111 522325
17
Clavulanic acid Approved, Vet_approved Phase 4 58001-44-8 5280980
18
Etanercept Approved, Investigational Phase 4 185243-69-0
19
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
20
Milnacipran Approved, Investigational Phase 4 92623-85-3, 96847-54-0 11622909 65833 6917779
21
Ibuprofen Approved Phase 4 15687-27-1 3672
22
Tranexamic acid Approved Phase 4 1197-18-8 5526
23
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
24
Acetaminophen Approved Phase 4 103-90-2 1983
25
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
26
Vancomycin Approved Phase 4 1404-90-6 14969
27
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3 3680
28
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 3003 5743
29
Cefazolin Approved Phase 4 25953-19-9 33255
30
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
31
Tramadol Approved, Investigational Phase 4 27203-92-5 33741 5523
32
Clindamycin Approved, Vet_approved Phase 4 18323-44-9, 24729-96-2 29029
33
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
34
Tranylcypromine Approved, Investigational Phase 4 155-09-9 5530 441233
35
Magnesium sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9
36
Magnesium oxide Approved Phase 4 1309-48-4 14792
37
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
38
Tizanidine Approved, Investigational Phase 4 51322-75-9 5487
39
Cefepime Approved, Investigational Phase 4 88040-23-7 5479537
40
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
41
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
42
Prednisolone Approved, Vet_approved Phase 4 50-24-8 4894 5755
43
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5 1875
44
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 4159 6741
45
Arachidonic Acid Experimental Phase 4 506-32-1 444899
46
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7 4897
47 Protective Agents Phase 4
48 Adjuvants, Immunologic Phase 4
49 Viscosupplements Phase 4
50 Hylan Phase 4

Interventional clinical trials:

(show top 50) (show all 765)
# Name Status NCT ID Phase Drugs
1 Topical Application of Tranexamic Acid in Joint Arthroplasty Completed NCT01937559 Phase 4 Normal saline
2 Determining the Optimal Dose of Tranexamic Acid in Decreasing Blood Loss During Lower Extremity Total Joint Arthroplasty Completed NCT02584725 Phase 4 Tranexamic Acid
3 A Prospective Study to Evaluate the Effect of rFVIII-FS in Different Prophylactic Regimens on Bleeding Events Frequency and Development of Arthropathy in Previously Treated and Minimally Treated Hemophilia A Pediatric Population. Completed NCT00632814 Phase 4 rFVIII-FS (Kogenate FS, BAY14-2222) 70 IU/kg, dosing once per week;rFVIII-FS (Kogenate FS, BAY14-2222), 70 IU/kg twice per week (30 IU/kg + 40 IU/kg);rFVIII-FS (Kogenate FS, BAY14-2222) 75 IU/kg, dosing three times per week (3 x 25 IU/kg)
4 Impact of Conservative Treatment by Custom-made Orthoses in Patients With Haemophilic Ankle Arthropathy Completed NCT00638001 Phase 4
5 Viscosupplementation in Patients With Hemophilic Arthropathy Completed NCT01748201 Phase 4
6 Pain After Total Knee Arthroplasty: a Comparison of Combined Continuous Adductor Canal Block With Infiltration of Local Anesthetic Between the Popliteal Artery and Capsule of the Knee Block Versus Continuous Adductor Canal Block Alone on Postoperative Analgesia Completed NCT03921034 Phase 4 Ropivacaine;Saline
7 Impact of Supra-inguinal Fascia Iliaca Compartment Block on Postoperative Opioid Consumption in Total Hip Arthroplasty Interventions by Posterior Approach Completed NCT04574479 Phase 4 Multimodal analgesia and PCA morphine pump
8 Consequence of the Learning Curve in Direct Anterior Approach for Total Hip Replacement Completed NCT02645435 Phase 4
9 The Impact of Dexmedetomidine on Tourniquet Induced -Systemic Effects in Total Knee Arthroplasty Under Spinal Anesthesia-prospective Study. Completed NCT04307290 Phase 4 Dexmedetomidine Hydrochloride, or Saline
10 Does Deep Neuromuscular Blockade Improve Operating Conditions During Total Hip Replacements? Completed NCT03219294 Phase 4 Vecuronium 0.1 mg/kg;Vecuronium 0.2mg/kg
11 Is Ceramic-on-Ceramic THA Superior to Ceramic-on-Highly Cross-Linked Polyethylene THA in Patients Less Than 55 Years Old? Completed NCT03639532 Phase 4
12 Randomized Controlled Doubleblind Pilot Study Comparing Analgosedation Concepts During Placement of Regional Anaesthesia With Either Fentanyl, Remifentanil, Clonidine, EMLA-Patch or Placebo in Regard of Pain Reduction. Completed NCT04026074 Phase 4 Fentanyl;Remifentanil;Clonidine;EMLA Cream;Placebo iv;Placebo salve
13 Liposomal Bupivacaine Interscalene Nerve Block in Shoulder Arthroplasty: A Single Blinded Prospective Randomized Control Trial Completed NCT03663283 Phase 4 Liposomal Bupivacaine;Bupivacaine Hydrochloride
14 Is Clinical Outcome of Robotic-Assisted TKA Better Than Conventional Manual TKA?Prospective, Randomized Study Completed NCT03659318 Phase 4
15 Phase IV Study of Landmarks for Spinal Anesthesia Completed NCT02330185 Phase 4
16 Supercapsular Percutaneously-Assisted Total Hip (SuperPATH®) Versus Conventional Posterior Approach for Total Hip Arthroplasty: A Prospective Randomized Controlled Study Completed NCT05147207 Phase 4
17 Periarticular Injection With Bupivacaine For Post-Operative Pain Control In Total Knee Replacement: A Prospective Randomized Double-Blind Controlled Trial Completed NCT01364194 Phase 4 0.25% Bupivacaine;0.9% normal saline
18 Fase IV Clinical Trial to Evaluate Chondroitin Sulphate Efficacy and Safety in Patients With Knee Osteoarthritis and Psoriasis Completed NCT00669123 Phase 4 Chondroitin sulphate;Placebo
19 Can Bone Erosions Heal in Adalimumab (Humira) Treated Rheumatoid Arthritis Patients. An Imaging Study Using Computed Tomography and Magnetic Resonance Imaging. Completed NCT00696059 Phase 4 Adalimumab (Humira)
20 Analgesic Duration of Interscalene Block After Outpatient Arthroscopic Shoulder Surgery With Intravenous Dexamethasone, Dexmedetomidine or Their Combination: A Randomized Controlled Trial Completed NCT03270033 Phase 4 Dexamethasone;Dexmedetomidine
21 Interscalene Block Versus Superior Trunk Block: A Randomized Controlled Clinical Trial Completed NCT03272139 Phase 4 Bupivacaine
22 Effect of Duloxetine on Opioid Use After Total Knee Arthroplasty: A Double-blinded Randomized Control Trial Completed NCT03271151 Phase 4 Cymbalta
23 Efficacy and Safety of the Infiltration of Autologous Plasma Rich in Growth Factors (PRGF) in the Symptomatic Treatment of Knee Osteoarthritis Completed NCT00782197 Phase 4
24 Adalimumab to Mitigate Cardiovascular Risk in RA Patients With Well-Controlled Joint Disease Completed NCT01893996 Phase 4 Adalimumab;Placebo
25 Hyaluronic Acid Evaluation as Adjuvant to Temporomandibular Joint Arthroscopy in Wilkes Stages Completed NCT04110587 Phase 4 Antibiotic therapy;corticosteroid;Antiinflammatories;Analgesics
26 Comparison of the Effect of a Single Shot Saphenous Block With Plain Bupivacaine vs. Protracted Bupivacaine Mixture as a Supplement to Continuous Sciatic Catheter After Major Ankle and Foot Surgery Completed NCT02346110 Phase 4 Bupivacaine-adrenaline;Dexamethasone
27 Comparison of Temporomandibular Joint Arthroscopy With Botulinum Toxin Injection Versus Placebo: a Randomized Clinical Trial Completed NCT04810429 Phase 4 Incobotulinumoxin A
28 A RANDOMIZED, OPEN-LABEL, TWO-PERIOD STUDY TO EVALUATE THE SAFETY AND EFFICACY OF ETANERCEPT ON SKIN AND JOINT DISEASE IN PSORIASIS SUBJECTS WITH PSORIATIC ARTHRITIS Completed NCT00245960 Phase 4 etanercept;Placebo
29 A Double Blind Randomised Study Comparing Hyaluronic Acid, Corticosteroid and Placebo During Arthrocentesis for Temporomandibular Joint Dysfunction Completed NCT01524913 Phase 4 Hyaluronic acid;Corticosteroid;Lactated Ringers
30 Milnacipran for the Pain, Sensory Sensitization and Mood Changes in Knee Osteoarthritis Completed NCT01510457 Phase 4 Milnacipran;Placebo
31 Efficacy of Intra-articular Injection of Combined Hyaluronic Acid and Platelet-rich Plasma in Knee Degenerative Joint Disease Completed NCT03211650 Phase 4 hyaluronic Acid + platelet-rich plasma;hyaluronic acid;platelet-rich plasma
32 Prevention of Postoperative Urinary Retention With Treatment of Tamsulosin 5 Days Prior to Lower Limb Arthroplasty Recruiting NCT03808155 Phase 4 Tamsulosin;Placebo Oral Tablet
33 Arthroscopic Rotator Cuff Repair Augmented With Regeneten Bioinductive Implant for Full-Thickness Tears: A Randomized Controlled Study Recruiting NCT05439850 Phase 4
34 The Effect of Tranexamic Acid on Calculated Total Blood Loss in Patients Undergoing Revision Shoulder Arthroplasty Recruiting NCT04650698 Phase 4 Tranexamic acid
35 Effect of Combinations of Paracetamol, Ibuprofen, and Dexamethasone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty. The RECIPE Randomized Clinical Trial Recruiting NCT04123873 Phase 4 Paracetamol;Ibuprofen;Dexamethasone;Placebo oral capsules;Placebo IV
36 Perioperative Antibiotic Prophylaxis in Patients Undergoing Elective Total Knee Arthroplasty: A Prospective, Randomized, Open-label, Controlled Multi-center Trial Recruiting NCT03283878 Phase 4 Cefazolin
37 The Efficacy of Long-Acting Nalbuphine Sebacate (Naldebain) for Pain Management After Knee Arthroplasty Recruiting NCT05266027 Phase 4 Nalbuphine Sebacate (Naldebain);Placebo medication
38 Blood-saving Effect of Kaolin-based Hemostatic Gauze Combined With Intravenous Tranexamic Acid in Total Knee Arthroplasty Recruiting NCT05504577 Phase 4 Tranexamic acid injection
39 Neuroendocrine Changes Associated With Magnesium Sulfate Administration in Surgical Patients Recruiting NCT04514731 Phase 4 Magnesium sulfate;Isotonic Saline
40 Multimodal Nonopioid Pain Protocol Following Shoulder Arthroplasty Surgery Recruiting NCT05488847 Phase 4 Celecoxib;Pregabalin;Tramadol;Dexamethasone;Acetaminophen;Ropivicaine;Epinephrine;Ketorolac;Tizanidine;Magnesium;Ibuprofen;Oxycodone Hydrochloride 5 Mg
41 Intraosseous Vancomycin in Primary Total Hip Arthroplasty - Designing a Protocol Recruiting NCT04042233 Phase 4 Experimental Intraosseous vancomycin 500mg in 250 mL NS;Standard IV administration of vancomycin
42 Autologous Platelet Rich Fibrin Versus Steroid in Ultrasound-Guided Sacroiliac Joint Injection for Joint Dysfunction (Randomized Comparative Study) Recruiting NCT04757740 Phase 4 methylprednisolone acetate and lidocaine
43 Safety of Ibuprofen After Major Orthopaedic Surgeries. The PERISAFE Randomized Clinical Multicentre Trial Not yet recruiting NCT05575700 Phase 4 Ibuprofen;Placebo
44 Single Blind Randomized Controlled Trial to Evaluate the Effect of Ketorolac in Hand and Wrist Tendinopathy and Arthropathy. Not yet recruiting NCT05292339 Phase 4 Triamcinolone injection to the hand or wrist;Ketorolac injection to the hand or wrist
45 Percutaneous Needle Fasciotomy (PNF) +/- Corticosteroid Injection for Dupuytren's Contracture (DC) Affecting Metacarpophalangeal Joints (MCP) . A Randomized Controlled Trial Not yet recruiting NCT05440240 Phase 4 Corticosteroid injection
46 Effect of Spinal Versus General Anesthesia on Cardiac and Renal Biomarker Levels in Hip and Knee Arthroplasty Surgery Terminated NCT03940651 Phase 4 Spinal Anesthesia;General Anesthetics
47 DURALOC® Option Ceramic-on-Ceramic Hip Prosthesis System PMA Post-approval Study Terminated NCT00546598 Phase 4
48 A Radiographic and Clinical Outcomes Study Evaluating map3® Cellular Allogeneic Bone Graft in Patients Undergoing Bone Grafting in the Foot/Ankle Terminated NCT02161016 Phase 4
49 Randomised, Controlled, Prospective, Multi-Centre, Post Market Surveillance Study Comparing a Ceramic-on-Metal Bearing and a Metal-on-Metal Bearing in Subjects Requiring Primary Total Hip Arthroplasty for Non-Inflammatory Degenerative Joint Disease Terminated NCT00873444 Phase 4
50 The Reverse Delta III Total Shoulder Prosthesis - Longerm Results in 98 Patients Withdrawn NCT01873651 Phase 4

Search NIH Clinical Center for Arthropathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Arthropathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Arthropathy:
BioSeed-C, a 3D chondrocyte graft for the treatment of articular cartilage defects
ChondroCelect, chondrocytes for treatment of cartilage knee defects
Chondrosphere (ACT3D-CS), articular chondrocyte spheroids for treatment of cartilage knee defects
DeNovo NT, particulated juvenile cartilage for cartilage repair
MACI, cultured chondrocytes for articular cartilage damage in joints
RevaFlex, engineered tissue graft of juvenile cartilage for cartilage repair
Embryonic/Adult Cultured Cells Related to Arthropathy:
Chondrocytes embedded in a 3D polymer scaffold (BioSeed-C) PMIDs: 21540360 19711090 17451597
Articular cartilage-derived cells (ChondroCelect)
Articular chondrocyte spheroids (Chondrosphere)
Matrix-induced autologous cultured chondrocytes (MACI) PMIDs: 22922521 21257846 19966108 16632362 20880476 23880403 19755063 15278206 16320051 19169789 22539536 22483735 24175609 24005872 22885840 12810965 23618699
Juvenile neocartilage (RevaFlex) PMIDs: 11603712 23465950 19880363 15742595 21828366 20025455 21439468 20423988

Cochrane evidence based reviews: joint diseases

Sources

Genetic Tests for Arthropathy

About this section

Genetic tests related to Arthropathy:

# Genetic test Affiliating Genes
1 Arthropathy 28
Sources

Anatomical Context for Arthropathy

About this section

Organs/tissues related to Arthropathy:

FMA: Joint
MalaCards : Bone, Bone Marrow, Dorsal Root Ganglion, Skeletal Muscle, Skin, Spinal Cord, Brain
Sources

Publications for Arthropathy

About this section

Articles related to Arthropathy:

(show top 50) (show all 17072)
# Title Authors PMID Year
1
In vitro expression of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in cultured equine articular cells. 53 62
20513175 2010
2
Precocious bilateral hip joint osteoarthritis is a "form-fruste" of the arthropathy of hereditary haemochromatosis. 53 62
19942354 2010
3
Factor VIII requirement to maintain a target plasma level in the prophylactic treatment of severe hemophilia A: influences of variance in pharmacokinetics and treatment regimens. 53 62
19943875 2010
4
[Monoclonal antibodies in chronic autoimmune inflammatory diseases]. 53 62
20035687 2009
5
Whole-body bone scintigraphy provides a measure of the total-body burden of osteoarthritis for the purpose of systemic biomarker validation. 53 62
19877068 2009
6
Correlation of gene and mediator expression with clinical endpoints in an acute interleukin-1beta-driven model of joint pathology. 53 62
19010066 2009
7
Break-through bleeding in relation to predicted factor VIII levels in patients receiving prophylactic treatment for severe hemophilia A. 53 62
19143924 2009
8
[Knee ochronotic arthropathy and arthroscopic findings]. 53 62
19293619 2009
9
The combination of the biomarkers urinary C-terminal telopeptide of type II collagen, serum cartilage oligomeric matrix protein, and serum chondroitin sulfate 846 reflects cartilage damage in hemophilic arthropathy. 53 62
19116938 2009
10
Circulating E-selectin and tumor necrosis factor-alpha in extraarticular involvement and joint disease activity in rheumatoid arthritis. 53 62
18726101 2009
11
Prevention of arthropathy: may it be extrapolated from patients without inhibitors to patients with inhibitors? 53 62
19134030 2008
12
Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis. 53 62
18759291 2008
13
[Biological treatment of psoriasis and psoriatic arthritis]. 53 62
18565300 2008
14
Etanercept. 53 62
18352852 2008
15
Economic evaluation of major knee surgery with recombinant activated factor VII in hemophilia patients with high titer inhibitors and advanced knee arthropathy: exploratory results via literature-based modeling. 53 62
18234151 2008
16
The hand arthropathy of hereditary hemochromatosis is strongly associated with iron overload. 53 62
18061976 2008
17
The role of VWF for the success of immune tolerance induction. 53 62
18549910 2008
18
WISP3 suppresses insulin-like growth factor signaling in human chondrocytes. 53 62
17942216 2007
19
Basic fibroblast growth factor activates the MAPK and NFkappaB pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes. 53 62
17724016 2007
20
TNFalpha antagonist therapy in patients with joint disease and chronic viral infection. 53 62
17644391 2007
21
Cuff tear arthropathy: evidence of functional variation in pyrophosphate metabolism genes. 53 62
17563703 2007
22
Effective therapy with anti-TNF-alpha in patients with psoriatic arthritis is associated with decreased levels of metalloproteinases and angiogenic cytokines in the sera and skin lesions. 53 62
17911474 2007
23
Comparing prophylaxis with episodic treatment in haemophilia A: implications for clinical practice. 53 62
17685917 2007
24
The anesthetic management of children with neonatal-onset multi-system inflammatory disease. 53 62
17646489 2007
25
[Recurrent new-onset uveitis in a patient with rheumatoid arthritis during anti-TNFalpha treatment]. 53 62
17603697 2007
26
Prevalence and risk factors of atherosclerosis in patients with psoriatic arthritis. 53 62
17067658 2007
27
Mutant WISP3 triggers the phenotype shift of articular chondrocytes by promoting sensitivity to IGF-1 hypothesis of spondyloepiphyseal dysplasia tarda with progressive arthropathy (SEDT-PA). 53 62
17363178 2007
28
Stimulation of osteoclast formation by inflammatory synovial fluid. 53 62
16642388 2006
29
Ochronotic rheumatism in Algeria: clinical, radiological, biological and molecular studies--a case study of 14 patients in 11 families. 53 62
16085442 2006
30
HFE gene mutations are associated with osteoarthritis in the index or middle finger metacarpophalangeal joints. 53 62
16583477 2006
31
A homozygous mutation in the lamin A/C gene associated with a novel syndrome of arthropathy, tendinous calcinosis, and progeroid features. 53 62
16278265 2006
32
Osteogenic protein 1 in synovial fluid from patients with rheumatoid arthritis or osteoarthritis: relationship with disease and levels of hyaluronan and antigenic keratan sulfate. 53 62
16646979 2006
33
Synovial fluid macrophages are capable of osteoclast formation and resorption. 53 62
16278818 2006
34
Matrix metalloproteinases MMP-3 and MMP-1 levels in sera and synovial fluids in patients with rheumatoid arthritis and osteoarthritis. 53 62
16688934 2005
35
Lack of genetic association of the three more common polymorphisms of CARD15 with psoriatic arthritis and psoriasis in a German cohort. 53 62
15539411 2005
36
HFE mutations in the pathobiology of hemophilic arthropathy. 53 62
15802547 2005
37
Diagnosis and treatment of psoriatic arthritis. 53 62
15627075 2005
38
Analysis of cartilage oligomeric matrix protein (COMP) degradation and synthesis in equine joint disease. 53 62
15651731 2005
39
Minocycline-induced hyperpigmentation masquerading as alkaptonuria in individuals with joint pain. 53 62
15529343 2004
40
Anti-CCP antibody test predicts the disease course during 3 years in early rheumatoid arthritis (the Swedish TIRA project). 53 62
15308517 2004
41
Bone morphogenetic protein (BMP)-2 enhances the expression of type II collagen and aggrecan in chondrocytes embedded in alginate beads. 53 62
15219571 2004
42
Simvastatin reduces MMP-3 level in interleukin 1beta stimulated human chondrocyte culture. 53 62
15194586 2004
43
A role for substance P in arthritis? 53 62
15135922 2004
44
Coagulation factors with improved properties for hemophilia gene therapy. 53 62
15118934 2004
45
Serum human cartilage glycoprotein 39 as a marker of arthritis associated with inflammatory bowel disease. 53 62
14644865 2003
46
YKL-39 (chitinase 3-like protein 2), but not YKL-40 (chitinase 3-like protein 1), is up regulated in osteoarthritic chondrocytes. 53 62
12972480 2003
47
Intraarticular release and accumulation of defensins and bactericidal/permeability-increasing protein in patients with rheumatoid arthritis. 53 62
12913926 2003
48
Comparison between women and men with recent onset rheumatoid arthritis of disease activity and functional ability over two years (the TIRA project). 53 62
12810432 2003
49
Growth plate damage, a feature of juvenile idiopathic arthritis, can be induced by adenoviral gene transfer of oncostatin M: a comparative study in gene-deficient mice. 53 62
12794844 2003
50
Osteoclasts, pro-inflammatory cytokines, RANK-L and bone remodeling in rheumatoid arthritis. 53 62
12700082 2003
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Variations for Arthropathy

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Expression for Arthropathy

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Search GEO for disease gene expression data for Arthropathy.
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Pathways for Arthropathy

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Pathways related to Arthropathy according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Mesenchymal Stem Cells and Lineage-specific Markers 65
11.72 IL6 COL2A1 ACAN
2
Spinal cord injury 74
11.68 TNF IL6 COL2A1 ACAN
3
Clock-controlled autophagy in bone metabolism 74
11.63 TNFSF11 TNFRSF11B IL6
4
Burn wound healing 74
11.59 TNF MMP2 IL6
5
Extrafollicular B cell activation by SARS-CoV-2 74
11.55 TNF IL6 CRP
6
Photodynamic therapy-induced NF-kB survival signaling 74
Show member pathways
 11.49 TNF MMP2 IL6
7
Lung fibrosis 74
11.47 TNF MMP2 IL6
8
IL 10 signaling pathway 67
11.45 TNFSF11 TNF IL6
9
IL6-mediated signaling events 61
11.26 CRP IL6 TNFSF11
10
Articular Cartilage Extracellular Matrix 65
11.14 COMP COL2A1 ACAN
11
amb2 Integrin signaling 61
10.9 TNF MMP2 IL6
12
Prostaglandin signaling 74
10.78 TNF NLRP3 IL6
13
G-protein signaling_Rap2B regulation pathway 22
10.75 TNFSF11 TNF PRG4 IL6 COL2A1 ACAN
14
Defective factor IX causes thrombophilia 66
Show member pathways
 10.64 F9 F8
15
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
10.58 TNFSF11 TNFRSF11B TNF IL6
16
Overview of nanoparticle effects 74
10.41 TNF IL6 CRP
17
Cells and molecules involved in local acute inflammatory response 74
Show member pathways
 10.16 TNF IL6
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GO Terms for Arthropathy

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Cellular components related to Arthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.12 ACAN ANKH B2M CCN6 COL2A1 COMP
2 collagen-containing extracellular matrix GO:0062023 10.03 PRG4 MMP2 F9 COMP COL2A1 ACAN
3 extracellular matrix GO:0031012 9.9 TNFRSF11B MMP2 COMP COL2A1 CCN6 ACAN
4 extracellular space GO:0005615 9.78 B2M CCN6 COL2A1 COMP CRP F8

Biological processes related to Arthropathy according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.26 TRPV4 TNFSF11 TNF IL6 HFE CRP
2 immune response GO:0006955 10.06 TNFSF11 TNF PRG4 MICA IL6 B2M
3 response to activity GO:0014823 9.99 TNF MMP2 IL6
4 defense response to Gram-positive bacterium GO:0050830 9.98 TNF NLRP3 IL6 CRP
5 acute-phase response GO:0006953 9.88 CRP F8 IL6
6 positive regulation of receptor binding GO:1900122 9.8 HFE B2M
7 negative regulation of neurogenesis GO:0050768 9.8 TNF IL6 B2M
8 regulation of iron ion transport GO:0034756 9.67 HFE B2M
9 osmosensory signaling pathway GO:0007231 9.65 NLRP3 TRPV4
10 skeletal system development GO:0001501 9.65 TNFRSF11B COMP COL2A1 ANKH ACAN
11 positive regulation of transferrin receptor binding GO:1904437 9.56 HFE B2M
12 positive regulation of ferrous iron binding GO:1904434 9.46 HFE B2M
13 negative regulation of lipid storage GO:0010888 9.1 TNF IL6 CRP
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Sources for Arthropathy

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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