Aliases & Classifications for Arthropathy

MalaCards integrated aliases for Arthropathy:

Name: Arthropathy 12 29 54 15 37 71
Joint Ankylosis of the Pelvic Region and Thigh 12
Ankylosis of Joint of Pelvic Region and Thigh 12
Joint Ankylosis of the Ankle and/or Foot 12
Ankylosis of Joint of Ankle and/or Foot 12
Joint Ankylosis of the Shoulder Region 12
Ankylosis of Joint of Shoulder Region 12
Joint Ankylosis of the Ankle and Foot 12
Arthropathy Associated with Infection 71
Ankylosis of Joint of Multiple Sites 12
Ankylosis of Ankle and Foot Joint 12
Joint Ankylosis of the Lower Leg 12
Joint Ankylosis of the Upper Arm 12
Ankylosis of Joint of Lower Leg 12
Ankylosis of Joint of Upper Arm 12
Joint Ankylosis of the Forearm 12
Ankylosis of Joint of Forearm 12
Ankylosis of Lower Leg Joint 12
Ankylosis of Multiple Joints 12
Ankylosis of Upper Arm Joint 12
Joint Ankylosis of the Hand 12
Ankylosis of Forearm Joint 12
Ankylosis of Joint of Hand 12
Ankylosis of Hand Joint 12
Infectious Arthropathy 12
Joint Diseases 43
Joint Disease 17


External Ids:

Disease Ontology 12 DOID:381
ICD9CM 34 711 719.90
MeSH 43 D007592
SNOMED-CT 67 396233005 399269003
UMLS 71 C0022408 C0157749

Summaries for Arthropathy

Disease Ontology : 12 A bone disease that is located in the joint.

MalaCards based summary : Arthropathy, also known as joint ankylosis of the pelvic region and thigh, is related to hemophilic arthropathy and reactive arthritis, and has symptoms including joint stiffness, arthralgia and back pain. An important gene associated with Arthropathy is PRG4 (Proteoglycan 4), and among its related pathways/superpathways are Fluid shear stress and atherosclerosis and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions. The drugs Prednisone and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and testes, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 74 An arthropathy is a disease of a... more...

Related Diseases for Arthropathy

Diseases in the Arthropathy family:

Transient Arthropathy

Diseases related to Arthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 970)
# Related Disease Score Top Affiliating Genes
1 hemophilic arthropathy 34.2 TNFSF11 TNFRSF11B HFE COMP
2 reactive arthritis 33.5 TNF IL1B CRP COMP
3 psoriatic arthritis 32.9 TNFSF11 TNFRSF11B TNF MICA IL1RAPL2 IL1B
4 ankylosis 32.8 TNFSF11 TNFRSF11B TNF CRP ANKH
5 cinca syndrome 32.6 NLRP3 IL1RAPL2 IL1B
6 osteoarthritis 32.3 TNFSF11 TNFRSF11B TNF PRG4 IL1B CRP
7 rheumatoid arthritis 31.9 TNFSF11 TNFRSF11B TNF MMP2 IL1RAPL2 IL1B
8 septic arthritis 31.8 TNF MMP2 IL1B CRP
9 hemarthrosis 31.6 F9 F8 ACAN
10 spondylitis 31.6 TNFSF11 TNF MICA CRP
11 multicentric reticulohistiocytosis 31.6 TNFSF11 TNFRSF11B
12 spondyloepiphyseal dysplasia with congenital joint dislocations 31.3 TRPV4 COMP CCN6 ACAN
13 chondrocalcinosis 31.2 TNFRSF11B NLRP3 IL1B HFE ANKH
14 syphilis 31.2 TNF CRP B2M
15 spondyloarthropathy 31.1 TNFSF11 TNF IL1B
16 pericarditis 31.1 TNF PRG4 IL1B CRP
17 spondyloarthropathy 1 31.0 TNFSF11 TNFRSF11B TNF IL1RAPL2 CRP B2M
18 synovitis 31.0 TNFSF11 TNFRSF11B TNF PRG4 IL1B CRP
19 osteomyelitis 30.9 TNFSF11 TNF NLRP3 IL1B
20 brucellosis 30.9 TNF MICA CRP
21 exanthem 30.9 TNF NLRP3 IL1B CRP
22 amyloidosis 30.8 TNF NLRP3 IL1B F9 CRP B2M
23 hyperostosis 30.8 TNFRSF11B MMP2 ANKH
24 peripheral nervous system disease 30.8 TRPV4 TNF IL1B CRP B2M
25 bursitis 30.8 TNF IL1B CRP
26 hypothyroidism 30.8 TNFRSF11B TNF F9 F8 CRP
27 osteonecrosis 30.7 TNFSF11 TNFRSF11B TNF IL1B
28 osteochondritis dissecans 30.6 PRG4 COMP ACAN
29 chondromalacia 30.6 TNF CRP COMP ACAN
30 tendinitis 30.6 TNF IL1B CRP COMP
31 crohn's disease 30.6 TNF NLRP3 IL1B CRP
32 brachydactyly 30.6 TRPV4 F8 COMP ACAN
33 scoliosis 30.6 TRPV4 TNFSF11 TNFRSF11B COMP CCN6 ACAN
34 bone resorption disease 30.6 TNFSF11 TNFRSF11B TNF IL1B CRP
35 urticaria 30.6 TNF NLRP3 CRP
36 polyneuropathy 30.5 TNF IL1B CRP B2M
37 amyloidosis aa 30.5 CRP B2M
38 inflammatory bowel disease 30.5 TNF NLRP3 MMP2 MICA IL1RAPL2 IL1B
39 connective tissue disease 30.5 TNFSF11 TNFRSF11B TNF MICA IL1B CRP
40 polyarticular onset juvenile idiopathic arthritis 30.4 TNFSF11 TNFRSF11B
41 inherited metabolic disorder 30.4 TNF IL1B HFE CRP
42 uremia 30.4 TNFRSF11B TNF CRP B2M
43 synovial angioma 30.4 F8 CRP
44 acute cystitis 30.3 TNF IL1B CRP
45 chronic meningitis 30.3 NLRP3 IL1B CRP
46 arthritis 30.3 TNFSF11 TNF MICA IL1B HGD HFE
47 compartment syndrome 30.3 TNF F8 CRP
48 celiac disease 1 30.3 TNF MICA IL1B HFE CRP
49 thrombophlebitis 30.3 TNF F8 CRP
50 keratitis, hereditary 30.3 TNF NLRP3 IL1B

Graphical network of the top 20 diseases related to Arthropathy:

Diseases related to Arthropathy

Symptoms & Phenotypes for Arthropathy

UMLS symptoms related to Arthropathy:

joint stiffness, arthralgia, back pain, sciatica, muscle cramp, metatarsalgia, joint symptom, musculoskeletal symptom, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm, other symptoms referable to joint, shoulder region, other symptoms referable to joint, upper arm, other symptoms referable to joint, forearm, other symptoms referable to joint, hand, other symptoms referable to joint, pelvic region and thigh, other symptoms referable to joint, lower leg, other symptoms referable to joint, ankle and foot, other symptoms referable to joint, other specified sites, other symptoms referable to joint, multiple sites, other symptoms referable to joint, site unspecified

MGI Mouse Phenotypes related to Arthropathy:

# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.1 ANKH B2M COMP CRP F8 F9
2 cardiovascular system MP:0005385 10.07 ANKH B2M COMP CRP F9 IL1B
3 hematopoietic system MP:0005397 10.06 ANKH B2M F8 F9 HFE IL1B
4 immune system MP:0005387 10 ANKH B2M COMP CRP F8 F9
5 limbs/digits/tail MP:0005371 9.5 ANKH COMP HFE NLRP3 TNF TNFRSF11B
6 skeleton MP:0005390 9.32 ANKH COMP HFE HGD IL1B MMP2

Drugs & Therapeutics for Arthropathy

Drugs for Arthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 408)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
Azithromycin Approved Phase 4 83905-01-5 447043 55185
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
Remifentanil Approved Phase 4 132875-61-7 60815
Prilocaine Approved Phase 4 721-50-6 4906
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
13 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Aminocaproic acid Approved, Investigational Phase 4 60-32-2 564
Levomilnacipran Approved, Investigational Phase 4 96847-54-0
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
tannic acid Approved Phase 4 1401-55-4
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 54677470 5281106
Aceclofenac Approved, Investigational Phase 4 89796-99-6
Etanercept Approved, Investigational Phase 4 185243-69-0
Abatacept Approved Phase 4 332348-12-6 10237
Acetaminophen Approved Phase 4 103-90-2 1983
Morphine Approved, Investigational Phase 4 57-27-2 5288826
Vancomycin Approved Phase 4 1404-90-6 14969 441141
Cefazolin Approved Phase 4 25953-19-9 656510 33255
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
Ibuprofen Approved Phase 4 15687-27-1 3672
Tranexamic Acid Approved Phase 4 1197-18-8 5526
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
Apremilast Approved, Investigational Phase 4 608141-41-9 11561674
Cefepime Approved, Investigational Phase 4 88040-23-7 5479537
Certolizumab pegol Approved Phase 4 428863-50-7
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
Infliximab Approved Phase 4 170277-31-3
Sodium citrate Approved, Investigational Phase 4 68-04-2
Allopurinol Approved Phase 4 315-30-0 2094
Norepinephrine Approved Phase 4 51-41-2 439260
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
Febuxostat Approved Phase 4 144060-53-7 134018
Chromium Approved Phase 4 7440-47-3 27668

Interventional clinical trials:

(show top 50) (show all 1031)
# Name Status NCT ID Phase Drugs
1 Adalimumab to Mitigate Cardiovascular Risk in RA Patients With Well-Controlled Joint Disease Unknown status NCT01893996 Phase 4 Adalimumab;Placebo
2 Subclinical Joint Bleeding in Irish Adults With Severe Haemophilia A on Personalised Prophylaxis Regimens Unknown status NCT02314325 Phase 4 ADVATE [Antihemophilic Factor (Recombinant)];ADVATE [Antihemophilic Factor (Recombinant)]
3 Targeting Synovitis in Early Rheumatoid Arthritis (TaSER). Intensive Management of Early Rheumatoid Arthritis Using Either Clinical or Musculoskeletal Ultrasound Assessment of Synovitis − a Randomised Study With Blinded Outcome Assessments Unknown status NCT00920478 Phase 4
4 Open Label Study of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
5 EVALUATION OF THE RELATIONSHIP BETWEEN EFFERVESCENT PARACETAMOL AND BLOOD PRESSURE. CLINICAL TRIAL. Unknown status NCT02514538 Phase 4 Non- effervescent Paracetamol kern;Effervescent paracetamol termalgin
6 Functional Improvement and Ultrasound Tissue Characterisation of the Achilles Tendon Following Sodium Hyaluronate Injection for Plantaris Friction Syndrome Unknown status NCT03077009 Phase 4 Hyaluronic Acid
7 A Randomized, Double-Blind, Two-Period Study to Evaluate the Safety and Efficacy of Etanercept on Skin and Joint Disease in Psoriasis Subjects With Psoriatic Arthritis. Completed NCT00245960 Phase 4 etanercept
8 Interscalene Block Versus Superior Trunk Block: A Randomized Controlled Clinical Trial Completed NCT03272139 Phase 4 Bupivacaine
9 Phase IV Study of Landmarks for Spinal Anesthesia Completed NCT02330185 Phase 4
10 Consequence of the Learning Curve in Direct Anterior Approach for Total Hip Replacement Completed NCT02645435 Phase 4
11 Randomized Controlled Doubleblind Pilot Study Comparing Analgosedation Concepts During Placement of Regional Anaesthesia With Either Fentanyl, Remifentanil, Clonidine, EMLA-Patch or Placebo in Regard of Pain Reduction. Completed NCT04026074 Phase 4 Fentanyl;Remifentanil;Clonidine;EMLA Cream;Placebo iv;Placebo salve
12 Viscosupplementation in Patients With Hemophilic Arthropathy Completed NCT01748201 Phase 4
13 Efficacy and Safety of the Infiltration of Autologous Plasma Rich in Growth Factors (PRGF) in the Symptomatic Treatment of Knee Osteoarthritis Completed NCT00782197 Phase 4
14 Pain After Total Knee Arthroplasty: a Comparison of Combined Continuous Adductor Canal Block With Infiltration of Local Anesthetic Between the Popliteal Artery and Capsule of the Knee Block Versus Continuous Adductor Canal Block Alone on Postoperative Analgesia Completed NCT03921034 Phase 4 Ropivacaine;Saline
15 Impact of Conservative Treatment by Custom-made Orthoses in Patients With Haemophilic Ankle Arthropathy Completed NCT00638001 Phase 4
16 Milnacipran for the Pain, Sensory Sensitization and Mood Changes in Knee Osteoarthritis Completed NCT01510457 Phase 4 Milnacipran;Placebo
17 The Impact of Dexmedetomidine on Tourniquet Induced -Systemic Effects in Total Knee Arthroplasty Under Spinal Anesthesia-prospective Study. Completed NCT04307290 Phase 4 Dexmedetomidine Hydrochloride, or Saline
18 Determining the Optimal Dose of Tranexamic Acid in Decreasing Blood Loss During Lower Extremity Total Joint Arthroplasty Completed NCT02584725 Phase 4 Tranexamic Acid
19 Does Deep Neuromuscular Blockade Improve Operating Conditions During Total Hip Replacements? Completed NCT03219294 Phase 4 Vecuronium 0.1 mg/kg;Vecuronium 0.2mg/kg
20 Fase IV Clinical Trial to Evaluate Chondroitin Sulphate Efficacy and Safety in Patients With Knee Osteoarthritis and Psoriasis Completed NCT00669123 Phase 4 Chondroitin sulphate;Placebo
21 A Prospective Study to Evaluate the Effect of rFVIII-FS in Different Prophylactic Regimens on Bleeding Events Frequency and Development of Arthropathy in Previously Treated and Minimally Treated Hemophilia A Pediatric Population. Completed NCT00632814 Phase 4 rFVIII-FS (Kogenate FS, BAY14-2222) 70 IU/kg, dosing once per week;rFVIII-FS (Kogenate FS, BAY14-2222), 70 IU/kg twice per week (30 IU/kg + 40 IU/kg);rFVIII-FS (Kogenate FS, BAY14-2222) 75 IU/kg, dosing three times per week (3 x 25 IU/kg)
22 Periarticular Injection With Bupivacaine For Post-Operative Pain Control In Total Knee Replacement: A Prospective Randomized Double-Blind Controlled Trial Completed NCT01364194 Phase 4 0.25% Bupivacaine;0.9% normal saline
23 Topical Application of Tranexamic Acid in Joint Arthroplasty Completed NCT01937559 Phase 4 Normal saline
24 A Prospective, Randomised, Uncontrolled, Single-Centre, Post-Market Surveillance Study To Evaluate The Performance Of SmartSet® HV and SmartSet® GHV Bone Cements In Primary Cemented Total Hip Arthroplasty(THA) Completed NCT00872066 Phase 4
25 A Randomized Controlled Trial of Tranexamic Acid and ε-Aminocaproic Acid to Reduce Blood Loss Following Total Knee Arthroplasty Completed NCT01873768 Phase 4 Tranexamic Acid (TXA);ε-Aminocaproic Acid (EACA)
26 Clinical Outcome With Attention to Functional Results One Year After Fixed or Mobile Bearing Total Knee Replacement in a Randomized Controlled Trial Completed NCT00822640 Phase 4
27 Hyaluronic Acid Evaluation as Adjuvant to Temporomandibular Joint Arthroscopy in Wilkes Stages Completed NCT04110587 Phase 4 Antibiotic therapy;corticosteroid;Antiinflammatories;Analgesics
28 A Double Blind Randomised Study Comparing Hyaluronic Acid, Corticosteroid and Placebo During Arthrocentesis for Temporomandibular Joint Dysfunction Completed NCT01524913 Phase 4 Hyaluronic acid;Corticosteroid;Lactated Ringers
29 The Effect of Subsartorial Saphenous Block on Postoperative Pain Following Major Ankle and Hind Foot Surgery Completed NCT02697955 Phase 4 Bupivacaine-epinephrine
30 A Prospective, Randomised, Controlled, Single Centre, Blinded Study of the Wear Characteristics of Two Polyethylene Bearing Surfaces, Enduron vs. Marathon Completed NCT00208442 Phase 4
31 Five-Year Outcome of Ceramic on Ceramic Bearing Versus Ceramic on Crossfire® Highly Cross-Linked Polyethylene Bearing in Primary Total Hip Arthroplasty: A Randomized Trial Completed NCT01522014 Phase 4
32 Whole Body Vibration Compared to Conventional Physiotherapy in Patients With Coxarthrosis: a Randomized, Controlled Study Completed NCT01279174 Phase 4
33 Can Bone Erosions Heal in Adalimumab (Humira) Treated Rheumatoid Arthritis Patients. An Imaging Study Using Computed Tomography and Magnetic Resonance Imaging. Completed NCT00696059 Phase 4 Adalimumab (Humira)
34 Comparison of the Effect of a Single Shot Saphenous Block With Plain Bupivacaine vs. Protracted Bupivacaine Mixture as a Supplement to Continuous Sciatic Catheter After Major Ankle and Foot Surgery Completed NCT02346110 Phase 4 Bupivacaine-adrenaline;Dexamethasone
35 Is Clinical Outcome of Robotic-Assisted TKA Better Than Conventional Manual TKA?Prospective, Randomized Study Completed NCT03659318 Phase 4
36 Is Ceramic-on-Ceramic THA Superior to Ceramic-on-Highly Cross-Linked Polyethylene THA in Patients Less Than 55 Years Old? Completed NCT03639532 Phase 4
37 Efficacy and Tolerability of Mud Packs Therapy in Osteoarthritis of the Hands: a One Year Follow-up Completed NCT00773682 Phase 4
38 A Multicentre Double-blind Randomised Controlled Trial to Assess the Clinical- and Cost-effectiveness of Facet-joint Injections in Selected Patients With Non-specific Low Back Pain: a Feasibility Study Completed NCT03339362 Phase 4
39 Functional Brain Imaging to Understand the Mechanisms of Pain Relief in Knee Osteoarthritis Completed NCT02208778 Phase 4 Duloxetine;Remifentanil;Placebo (for Remifentanil);Placebo (for Duloxetine)
40 A Phase IIIb Open-label run-in Double-blind, Placebo Controlled, Randomized Study to Evaluate the Safety/Efficacy of Certolizumab Pegol Administered Concomitantly With Stable-dose Methotrexate in Patients With Active Rheumatoid Arthritis. Completed NCT00580840 Phase 4 Certolizumab pegol;Certolizumab pegol
41 Randomized Controlled Trial of Tranexamic Acid in Total Knee Arthroplasty: Intravenous vs. Topical Completed NCT01940523 Phase 4 Topical Tranexamic Acid;Intravenous Tranexamic Acid
42 Efficacy and Safety of Intra-Articular Injections of Durolane® in the Treatment of Osteoarthritis in the Knee Completed NCT00731289 Phase 4 hyaluronic acid;triamcinolone
43 Effectiveness of Triamcinolone Hexacetonide Intra-articular Injection in Interphalangeal Joints: a 12 Weeks Randomized Controlled Trial in Osteoarthritis Hand Patients Completed NCT02102620 Phase 4 Intra-articular injection with corticosteroid;Intra-articular injection with lidocaine
44 A Comparison of Tramadol/Acetaminophen Tablets Maintenance Versus NSAID Maintenance After Tramadol/Acetaminophen and NSAID Combination Therapy in Knee Osteoarthritis Patients: Multicenter, Randomized, Open Comparative Study Completed NCT00635349 Phase 4 Meloxicam;Aceclofenac;Tramadol Hydrochloride Plus Acetaminophen
45 The Comparison of Knee Osteoarthritis Treatment With Single-dose of Bone Marrow Aspirate Concentrate, Single-dose of Leukocyte Rich Platelet Rich Plasma and 3 Injection of High Molecular Weight Hyaluronic Acid-A Randomized Clinical Trial Completed NCT03825133 Phase 4 Hyaluronic Acid
46 Effect of Regenerative Injection Therapy on Function and Pain in Patients With Knee Osteoarthritis Completed NCT01206634 Phase 4
47 Comparison Between Single Shot Peripheral Nerve Block and Continuous Infusion Via a On-Q Pump in Extremity Fracture Operations: a Randomized Prospective Control Trial Completed NCT02280291 Phase 4 Ankle SSB;Ankle OnQ;DR SSB;DR OnQ
48 Analgesic Duration of Interscalene Block After Outpatient Arthroscopic Shoulder Surgery With Intravenous Dexamethasone, Dexmedetomidine or Their Combination: A Randomized Controlled Trial Completed NCT03270033 Phase 4 Dexamethasone;Dexmedetomidine
49 Efficacy and Cost Effectiveness of Standard Versus Pharmacokinetic Dosing During Factor VIII Prophylaxis in Adult Patients With Severe Haemophilia A Completed NCT02697370 Phase 4 Pharmacokinetic based dosage change
50 Abatacept Bone Effects in Psoriatic Arthritis With Bone Biomarkers - ABEPSA _ BB Recruiting NCT04106804 Phase 4 Abatacept 125 MG/ML

Search NIH Clinical Center for Arthropathy

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Arthropathy cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: joint diseases

Genetic Tests for Arthropathy

Genetic tests related to Arthropathy:

# Genetic test Affiliating Genes
1 Arthropathy 29

Anatomical Context for Arthropathy

The Foundational Model of Anatomy Ontology organs/tissues related to Arthropathy:


MalaCards organs/tissues related to Arthropathy:

Bone, Testes, T Cells, Skin, Bone Marrow, Spinal Cord, Monocytes

Publications for Arthropathy

Articles related to Arthropathy:

(show top 50) (show all 10633)
# Title Authors PMID Year
[Bone and joint diseases in children. Phosphaturic hormone, FGF23, and bone metabolism]. 61 54
20513948 2010
Precocious bilateral hip joint osteoarthritis is a "form-fruste" of the arthropathy of hereditary haemochromatosis. 61 54
19942354 2010
Factor VIII requirement to maintain a target plasma level in the prophylactic treatment of severe hemophilia A: influences of variance in pharmacokinetics and treatment regimens. 61 54
19943875 2010
[Monoclonal antibodies in chronic autoimmune inflammatory diseases]. 61 54
20035687 2009
Adipokines in the skeleton: influence on cartilage function and joint degenerative diseases. 54 61
19240195 2009
New insights into BMP-7 mediated osteoblastic differentiation of primary human mesenchymal stem cells. 61 54
19306956 2009
Correlation of gene and mediator expression with clinical endpoints in an acute interleukin-1beta-driven model of joint pathology. 61 54
19010066 2009
Break-through bleeding in relation to predicted factor VIII levels in patients receiving prophylactic treatment for severe hemophilia A. 61 54
19143924 2009
The combination of the biomarkers urinary C-terminal telopeptide of type II collagen, serum cartilage oligomeric matrix protein, and serum chondroitin sulfate 846 reflects cartilage damage in hemophilic arthropathy. 61 54
19116938 2009
[Knee ochronotic arthropathy and arthroscopic findings]. 54 61
19293619 2009
Prevention of arthropathy: may it be extrapolated from patients without inhibitors to patients with inhibitors? 54 61
19134030 2008
Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis. 54 61
18759291 2008
Economic evaluation of major knee surgery with recombinant activated factor VII in hemophilia patients with high titer inhibitors and advanced knee arthropathy: exploratory results via literature-based modeling. 61 54
18234151 2008
Joint diseases and matrix metalloproteinases: a role for MMP-13. 61 54
18289056 2008
[Genomic approaches to bone and joint diseases. Mutations of RANK, OPG and RANKL genes found in humans]. 61 54
18245890 2008
The hand arthropathy of hereditary hemochromatosis is strongly associated with iron overload. 61 54
18061976 2008
The role of VWF for the success of immune tolerance induction. 54 61
18549910 2008
WISP3 suppresses insulin-like growth factor signaling in human chondrocytes. 54 61
17942216 2007
Basic fibroblast growth factor activates the MAPK and NFkappaB pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes. 54 61
17724016 2007
Comparing prophylaxis with episodic treatment in haemophilia A: implications for clinical practice. 54 61
17685917 2007
Effective therapy with anti-TNF-alpha in patients with psoriatic arthritis is associated with decreased levels of metalloproteinases and angiogenic cytokines in the sera and skin lesions. 54 61
17911474 2007
Cuff tear arthropathy: evidence of functional variation in pyrophosphate metabolism genes. 61 54
17563703 2007
The anesthetic management of children with neonatal-onset multi-system inflammatory disease. 54 61
17646489 2007
Osteochondral repair in synovial joints. 61 54
17414953 2007
Mutant WISP3 triggers the phenotype shift of articular chondrocytes by promoting sensitivity to IGF-1 hypothesis of spondyloepiphyseal dysplasia tarda with progressive arthropathy (SEDT-PA). 54 61
17363178 2007
Stimulation of osteoclast formation by inflammatory synovial fluid. 54 61
16642388 2006
Ochronotic rheumatism in Algeria: clinical, radiological, biological and molecular studies--a case study of 14 patients in 11 families. 54 61
16085442 2006
HFE gene mutations are associated with osteoarthritis in the index or middle finger metacarpophalangeal joints. 54 61
16583477 2006
A homozygous mutation in the lamin A/C gene associated with a novel syndrome of arthropathy, tendinous calcinosis, and progeroid features. 61 54
16278265 2006
Synovial fluid macrophages are capable of osteoclast formation and resorption. 61 54
16278818 2006
HFE mutations in the pathobiology of hemophilic arthropathy. 61 54
15802547 2005
Analysis of cartilage oligomeric matrix protein (COMP) degradation and synthesis in equine joint disease. 54 61
15651731 2005
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS): definition, semiology, prognosis, pathogenesis, treatment, and place relative to other periodic joint diseases. 54 61
15288852 2004
Simvastatin reduces MMP-3 level in interleukin 1beta stimulated human chondrocyte culture. 61 54
15194586 2004
Coagulation factors with improved properties for hemophilia gene therapy. 61 54
15118934 2004
Serum human cartilage glycoprotein 39 as a marker of arthritis associated with inflammatory bowel disease. 54 61
14644865 2003
Effect of propolis on human cartilage and chondrocytes. 54 61
12818355 2003
The Hemophilia Utilization Group Study (HUGS): determinants of costs of care in persons with haemophilia A. 61 54
12694525 2003
Osteoclasts, pro-inflammatory cytokines, RANK-L and bone remodeling in rheumatoid arthritis. 54 61
12700082 2003
Elevated levels of synovial fluid antibodies reactive with the small proteoglycans biglycan and decorin in patients with rheumatoid arthritis or other joint diseases. 61 54
12649398 2003
Vitreoretinopathy with phalangeal epiphyseal dysplasia, a type II collagenopathy resulting from a novel mutation in the C-propeptide region of the molecule. 54 61
12205109 2002
Concentrations of cartilage oligomeric matrix protein in dogs with naturally developing and experimentally induced arthropathy. 54 61
11939326 2002
Hemophilic arthropathy. A scoring system for magnetic resonance imaging. 61 54
11960235 2002
Clinical significance of cytokine determination in synovial fluid. 61 54
11890208 2002
Persistence of parvovirus B19 DNA in synovium of patients with haemophilic arthritis. 54 61
11536251 2001
Arthropathy in hereditary hemochromatosis. 54 61
11148720 2001
Increased synovial fluid levels of interleukin-12, sCD25 and sTNF-RII/sTNF-RI ratio delineate a cytokine pattern characteristic of immune arthropathies. 54 61
11125312 2000
Synovial fluid matrix metalloproteinase-3 levels are increased in inflammatory arthritides whether erosive or not. 54 61
11136879 2000
Synovial hyperplasia in HTLV-I associated arthropathy is induced by tumor necrosis factor-alpha produced by HTLV-I infected CD68+ cells. 54 61
10782809 2000
Specific expression of interleukin-1 beta in temporomandibular joints with internal derangement: correlation with clinical findings. 61 54
10519747 1999

Variations for Arthropathy

Expression for Arthropathy

Search GEO for disease gene expression data for Arthropathy.

Pathways for Arthropathy

Pathways related to Arthropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.6 TRPV4 TNF MMP2 IL1B
Show member pathways
3 11.49 TNF NLRP3 IL1B
Show member pathways
11.38 TNF MMP2 IL1B
6 11.34 TNF MMP2 IL1B
7 11.2 TNF IL1B COMP
Show member pathways

GO Terms for Arthropathy

Cellular components related to Arthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 TNFSF11 TNFRSF11B TNF PRG4 NLRP3 MMP2
2 collagen-containing extracellular matrix GO:0062023 9.65 PRG4 MMP2 F9 COMP ACAN
3 extracellular matrix GO:0031012 9.55 TNFRSF11B MMP2 COMP CCN6 ACAN
4 extracellular space GO:0005615 9.44 TNFSF11 TNFRSF11B TNF MMP2 MICA IL1B
5 MHC class I protein complex GO:0042612 9.37 HFE B2M
6 HFE-transferrin receptor complex GO:1990712 9.32 HFE B2M

Biological processes related to Arthropathy according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.88 TNFSF11 TNF PRG4 MICA IL1B B2M
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 TNFSF11 TNF NLRP3 IL1B
3 positive regulation of gene expression GO:0010628 9.85 TRPV4 TNFSF11 TNF IL1B HFE CRP
4 skeletal system development GO:0001501 9.84 TNFRSF11B COMP ANKH ACAN
5 cytokine-mediated signaling pathway GO:0019221 9.83 TNFSF11 TNF MMP2 IL1RAPL2 IL1B
6 positive regulation of interleukin-6 secretion GO:2000778 9.7 TRPV4 TNF IL1B
7 acute-phase response GO:0006953 9.67 HFE F8 CRP
8 extracellular matrix organization GO:0030198 9.65 TNFRSF11B TNF MMP2 COMP ACAN
9 positive regulation of neuroinflammatory response GO:0150078 9.62 TNF IL1B
10 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.62 TRPV4 IL1B
11 negative regulation of lipid storage GO:0010888 9.61 TNF CRP
12 negative regulation of receptor binding GO:1900121 9.61 HFE B2M
13 cellular response to nicotine GO:0071316 9.6 TNF B2M
14 regulation of establishment of endothelial barrier GO:1903140 9.59 TNF IL1B
15 positive regulation of receptor binding GO:1900122 9.58 HFE B2M
16 cellular response to iron ion GO:0071281 9.58 HFE B2M
17 interleukin-1 beta production GO:0032611 9.57 NLRP3 IL1B
18 positive regulation of fever generation GO:0031622 9.56 TNF IL1B
19 sequestering of triglyceride GO:0030730 9.51 TNF IL1B
20 negative regulation of neurogenesis GO:0050768 9.5 TNF IL1B B2M
21 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.48 TNF IL1B
22 regulation of iron ion transport GO:0034756 9.46 HFE B2M
23 positive regulation of transferrin receptor binding GO:1904437 9.16 HFE B2M
24 positive regulation of ferrous iron binding GO:1904434 8.96 HFE B2M
25 positive regulation of JNK cascade GO:0046330 8.92 TRPV4 TNFSF11 TNF IL1B

Molecular functions related to Arthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.7 TRPV4 TNFSF11 TNF