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MCID: ART023
MIFTS: 61

Arthropathy

Categories: Bone diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Arthropathy

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MalaCards integrated aliases for Arthropathy:

Name: Arthropathy 12 29 54 15 37 71
Joint Ankylosis of the Pelvic Region and Thigh 12
Ankylosis of Joint of Pelvic Region and Thigh 12
Joint Ankylosis of the Ankle and/or Foot 12
Ankylosis of Joint of Ankle and/or Foot 12
Joint Ankylosis of the Shoulder Region 12
Ankylosis of Joint of Shoulder Region 12
Joint Ankylosis of the Ankle and Foot 12
Arthropathy Associated with Infection 71
Ankylosis of Joint of Multiple Sites 12
Ankylosis of Ankle and Foot Joint 12
Joint Ankylosis of the Lower Leg 12
Joint Ankylosis of the Upper Arm 12
Ankylosis of Joint of Lower Leg 12
Ankylosis of Joint of Upper Arm 12
Joint Ankylosis of the Forearm 12
Ankylosis of Joint of Forearm 12
Ankylosis of Lower Leg Joint 12
Ankylosis of Multiple Joints 12
Ankylosis of Upper Arm Joint 12
Joint Ankylosis of the Hand 12
Ankylosis of Forearm Joint 12
Ankylosis of Joint of Hand 12
Ankylosis of Hand Joint 12
Infectious Arthropathy 12
Joint Diseases 44
Joint Disease 17

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:381
ICD9CM 34 711 719.90
MeSH 44 D007592
SNOMED-CT 67 48548006 8316001
UMLS 71 C0022408 C0157749
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Summaries for Arthropathy

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Disease Ontology : 12 A bone disease that is located in the joint.

MalaCards based summary : Arthropathy, also known as joint ankylosis of the pelvic region and thigh, is related to familial calcium pyrophosphate deposition and hemophilic arthropathy, and has symptoms including joint stiffness, back pain and arthralgia. An important gene associated with Arthropathy is PRG4 (Proteoglycan 4), and among its related pathways/superpathways are IL6-mediated signaling events and TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions. The drugs Triamcinolone and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and bone marrow, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia : 74 An arthropathy is a disease of a... more...

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Related Diseases for Arthropathy

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Diseases in the Arthropathy family:

Transient Arthropathy

Diseases related to Arthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 989)
# Related Disease Score Top Affiliating Genes
1 familial calcium pyrophosphate deposition 32.3 TNFRSF11B ANKH
2 hemophilic arthropathy 32.3 TNFSF11 TNFRSF11B HFE COMP
3 reactive arthritis 32.3 TNF IL6 CRP COMP
4 psoriatic arthritis 32.0 TNFSF11 TNF MICA IL6 IL1RAPL2 CRP
5 ankylosis 31.8 TNFSF11 TNFRSF11B TNF ANKH
6 osteoarthritis 31.5 TNFSF11 TNFRSF11B TNF PRG4 IL6 CRP
7 hemarthrosis 31.3 F9 F8 ACAN
8 chondrocalcinosis 31.3 TNFRSF11B NLRP3 HFE ANKH
9 enthesopathy 31.0 TNF CRP ANKH ACAN
10 rheumatoid arthritis 31.0 TNFSF11 TNFRSF11B TNF MMP2 IL6 IL1RAPL2
11 spondyloepiphyseal dysplasia with congenital joint dislocations 31.0 TRPV4 COMP CCN6 ACAN
12 pericarditis 31.0 TNF PRG4 IL6 CRP
13 carpal tunnel syndrome 31.0 IL6 COMP B2M
14 tenosynovitis 31.0 TNF IL6 CRP
15 spondylitis 30.9 TNFSF11 TNF MICA IL6 CRP
16 synovitis 30.9 TNFSF11 TNFRSF11B TNF PRG4 IL6 CRP
17 spondyloarthropathy 30.9 TNFSF11 TNF IL6
18 exanthem 30.8 TNF NLRP3 IL6 CRP
19 amyloidosis 30.8 TNF NLRP3 IL6 F9 CRP B2M
20 peripheral nervous system disease 30.7 TRPV4 TNF IL6 HFE CRP B2M
21 osteomyelitis 30.6 TNFSF11 TNF NLRP3 IL6 CRP
22 bursitis 30.6 TNF IL6 CRP
23 osteonecrosis 30.6 TNFSF11 TNFRSF11B TNF
24 spondyloarthropathy 1 30.6 TNFSF11 TNFRSF11B TNF IL6 CRP ANKH
25 periarthritis 30.6 B2M ANKH
26 thyroiditis 30.6 TNF IL6 CRP
27 hemophilia b 30.6 TNFRSF11B F9 F8
28 tendinitis 30.5 TNF IL6 CRP COMP
29 brucellosis 30.5 TNF IL6 CRP
30 connective tissue disease 30.5 TNFSF11 TNF MICA IL6 CRP ACAN
31 chlamydia 30.4 TNF IL6 CRP
32 neuritis 30.4 TNF MMP2 IL6 HFE
33 hyperostosis 30.4 TNFRSF11B MMP2 ANKH
34 bone resorption disease 30.4 TNFSF11 TNFRSF11B TNF IL6 CRP
35 atherosclerosis susceptibility 30.4 TNF NLRP3 IL6 CRP
36 relapsing polychondritis 30.4 IL6 CRP COMP
37 crohn's disease 30.4 TNF NLRP3 IL6 CRP
38 erythema nodosum 30.4 TNF IL6 CRP
39 inherited metabolic disorder 30.4 TNF IL6 HFE CRP
40 juvenile arthritis 30.3 IL6 IL1RAPL2 CRP
41 pericardial effusion 30.3 NLRP3 IL6 CRP
42 osteochondritis dissecans 30.3 PRG4 COMP ACAN
43 iridocyclitis 30.3 TNF IL6 CRP
44 urticaria 30.2 TNF NLRP3 IL6 CRP
45 celiac disease 1 30.2 TNF IL6 HFE CRP
46 brachydactyly 30.2 TRPV4 F8 COMP ACAN
47 multicentric reticulohistiocytosis 30.2 TNFSF11 TNFRSF11B
48 scleritis 30.2 TNF IL1RAPL2 CRP
49 amyloidosis aa 30.2 CRP B2M
50 fibromyalgia 30.2 TNF IL6 CRP

Graphical network of the top 20 diseases related to Arthropathy:



Diseases related to Arthropathy
Sources

Symptoms & Phenotypes for Arthropathy

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UMLS symptoms related to Arthropathy:


joint stiffness, back pain, arthralgia, sciatica, muscle cramp, metatarsalgia, joint symptom, musculoskeletal symptom, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm, other symptoms referable to joint, shoulder region, other symptoms referable to joint, upper arm, other symptoms referable to joint, forearm, other symptoms referable to joint, hand, other symptoms referable to joint, pelvic region and thigh, other symptoms referable to joint, lower leg, other symptoms referable to joint, ankle and foot, other symptoms referable to joint, other specified sites, other symptoms referable to joint, multiple sites, other symptoms referable to joint, site unspecified

MGI Mouse Phenotypes related to Arthropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.1 ANKH B2M COMP CRP F8 F9
2 immune system MP:0005387 10 ANKH B2M COMP CRP F8 F9
3 limbs/digits/tail MP:0005371 9.5 ANKH COMP HFE NLRP3 TNF TNFRSF11B
4 skeleton MP:0005390 9.32 ANKH COMP HFE HGD IL6 MMP2
Sources

Drugs & Therapeutics for Arthropathy

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Drugs for Arthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 278)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
2
Etanercept Approved, Investigational Phase 4 185243-69-0
3
Adalimumab Approved, Experimental Phase 4 331731-18-1 16219006
4
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
5
Remifentanil Approved Phase 4 132875-61-7 60815
6
Prilocaine Approved Phase 4 721-50-6 4906
7
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
8
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
9
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
10
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
11
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
12
Levomilnacipran Approved, Investigational Phase 4 96847-54-0
13
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
14
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
15
Morphine Approved, Investigational Phase 4 57-27-2 5288826
16
Vancomycin Approved Phase 4 1404-90-6 441141 14969
17
Cefazolin Approved Phase 4 25953-19-9 656510 33255
18
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
19
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
20
Cefepime Approved, Investigational Phase 4 88040-23-7 5479537
21
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
22
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
23
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
24
Norepinephrine Approved Phase 4 51-41-2 439260
25
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
26
Tranexamic Acid Approved Phase 4 1197-18-8 5526
27
Chromium Approved Phase 4 7440-47-3 27668
28
Cobalt Approved, Experimental Phase 4 7440-48-4 104729
29
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
30 Triamcinolone hexacetonide Phase 4
31 triamcinolone acetonide Phase 4
32 Triamcinolone diacetate Phase 4
33 Cholinergic Agents Phase 4
34 Factor VIII Phase 4
35 Hylan Phase 4
36 Lidocaine, Prilocaine Drug Combination Phase 4
37 BB 1101 Phase 4
38 HIV Protease Inhibitors Phase 4
39
protease inhibitors Phase 4
40 Dexamethasone 21-phosphate Phase 4
41 Vecuronium Bromide Phase 4 50700-72-6
42 Neuromuscular Blocking Agents Phase 4
43 Neuromuscular Nondepolarizing Agents Phase 4
44 Cholinergic Antagonists Phase 4
45 Bromides Phase 4
46 Cholinesterase Inhibitors Phase 4
47
Chondroitin Phase 4 9007-27-6 14389182
48 Betamethasone sodium phosphate Phase 4
49 Betamethasone benzoate Phase 4
50 Betamethasone-17,21-dipropionate Phase 4

Interventional clinical trials:

(show top 50) (show all 667)
# Name Status NCT ID Phase Drugs
1 Adalimumab to Mitigate Cardiovascular Risk in RA Patients With Well-Controlled Joint Disease Unknown status NCT01893996 Phase 4 Adalimumab;Placebo
2 Efficacy and Safety of the Infiltration of Autologous Plasma Rich in Growth Factors (PRGF) in the Symptomatic Treatment of Knee Osteoarthritis Completed NCT00782197 Phase 4
3 Interscalene Block Versus Superior Trunk Block: A Randomized Controlled Clinical Trial Completed NCT03272139 Phase 4 Bupivacaine
4 A Randomized, Double-Blind, Two-Period Study to Evaluate the Safety and Efficacy of Etanercept on Skin and Joint Disease in Psoriasis Subjects With Psoriatic Arthritis. Completed NCT00245960 Phase 4 etanercept
5 Viscosupplementation in Patients With Hemophilic Arthropathy Completed NCT01748201 Phase 4
6 The Impact of Dexmedetomidine on Tourniquet Induced -Systemic Effects in Total Knee Arthroplasty Under Spinal Anesthesia-prospective Study. Completed NCT04307290 Phase 4 Dexmedetomidine Hydrochloride, or Saline
7 Determining the Optimal Dose of Tranexamic Acid in Decreasing Blood Loss During Lower Extremity Total Joint Arthroplasty Completed NCT02584725 Phase 4 Tranexamic Acid
8 Consequence of the Learning Curve in Direct Anterior Approach for Total Hip Replacement Completed NCT02645435 Phase 4
9 Randomized Controlled Doubleblind Pilot Study Comparing Analgosedation Concepts During Placement of Regional Anaesthesia With Either Fentanyl, Remifentanil, Clonidine, EMLA-Patch or Placebo in Regard of Pain Reduction. Completed NCT04026074 Phase 4 Fentanyl;Remifentanil;Clonidine;EMLA Cream;Placebo iv;Placebo salve
10 Pain After Total Knee Arthroplasty: a Comparison of Combined Continuous Adductor Canal Block With Infiltration of Local Anesthetic Between the Popliteal Artery and Capsule of the Knee Block Versus Continuous Adductor Canal Block Alone on Postoperative Analgesia Completed NCT03921034 Phase 4 Ropivacaine;Saline
11 Phase IV Study of Landmarks for Spinal Anesthesia Completed NCT02330185 Phase 4
12 Does Deep Neuromuscular Blockade Improve Operating Conditions During Total Hip Replacements? Completed NCT03219294 Phase 4 Vecuronium 0.1 mg/kg;Vecuronium 0.2mg/kg
13 Impact of Conservative Treatment by Custom-made Orthoses in Patients With Haemophilic Ankle Arthropathy Completed NCT00638001 Phase 4
14 A Prospective Study to Evaluate the Effect of rFVIII-FS in Different Prophylactic Regimens on Bleeding Events Frequency and Development of Arthropathy in Previously Treated and Minimally Treated Hemophilia A Pediatric Population. Completed NCT00632814 Phase 4 rFVIII-FS (Kogenate FS, BAY14-2222) 70 IU/kg, dosing once per week;rFVIII-FS (Kogenate FS, BAY14-2222), 70 IU/kg twice per week (30 IU/kg + 40 IU/kg);rFVIII-FS (Kogenate FS, BAY14-2222) 75 IU/kg, dosing three times per week (3 x 25 IU/kg)
15 Periarticular Injection With Bupivacaine For Post-Operative Pain Control In Total Knee Replacement: A Prospective Randomized Double-Blind Controlled Trial Completed NCT01364194 Phase 4 0.25% Bupivacaine;0.9% normal saline
16 Can Bone Erosions Heal in Adalimumab (Humira) Treated Rheumatoid Arthritis Patients. An Imaging Study Using Computed Tomography and Magnetic Resonance Imaging. Completed NCT00696059 Phase 4 Adalimumab (Humira)
17 The Effect of Subsartorial Saphenous Block on Postoperative Pain Following Major Ankle and Hind Foot Surgery Completed NCT02697955 Phase 4 Bupivacaine-epinephrine
18 Topical Application of Tranexamic Acid in Joint Arthroplasty Completed NCT01937559 Phase 4 Normal saline
19 Effect of Regenerative Injection Therapy on Function and Pain in Patients With Knee Osteoarthritis Completed NCT01206634 Phase 4
20 Fase IV Clinical Trial to Evaluate Chondroitin Sulphate Efficacy and Safety in Patients With Knee Osteoarthritis and Psoriasis Completed NCT00669123 Phase 4 Chondroitin sulphate;Placebo
21 A Double Blind Randomised Study Comparing Hyaluronic Acid, Corticosteroid and Placebo During Arthrocentesis for Temporomandibular Joint Dysfunction Completed NCT01524913 Phase 4 Hyaluronic acid;Corticosteroid;Lactated Ringers
22 Milnacipran for the Pain, Sensory Sensitization and Mood Changes in Knee Osteoarthritis Completed NCT01510457 Phase 4 Milnacipran;Placebo
23 Analgesic Duration of Interscalene Block After Outpatient Arthroscopic Shoulder Surgery With Intravenous Dexamethasone, Dexmedetomidine or Their Combination: A Randomized Controlled Trial Completed NCT03270033 Phase 4 Dexamethasone;Dexmedetomidine
24 Hyaluronic Acid Evaluation as Adjuvant to Temporomandibular Joint Arthroscopy in Wilkes Stages Completed NCT04110587 Phase 4 Antibiotic therapy;corticosteroid;Antiinflammatories;Analgesics
25 Comparison of the Effect of a Single Shot Saphenous Block With Plain Bupivacaine vs. Protracted Bupivacaine Mixture as a Supplement to Continuous Sciatic Catheter After Major Ankle and Foot Surgery Completed NCT02346110 Phase 4 Bupivacaine-adrenaline;Dexamethasone
26 Clinical Outcome With Attention to Functional Results One Year After Fixed or Mobile Bearing Total Knee Replacement in a Randomized Controlled Trial Completed NCT00822640 Phase 4
27 Is Clinical Outcome of Robotic-Assisted TKA Better Than Conventional Manual TKA?Prospective, Randomized Study Completed NCT03659318 Phase 4
28 Is Ceramic-on-Ceramic THA Superior to Ceramic-on-Highly Cross-Linked Polyethylene THA in Patients Less Than 55 Years Old? Completed NCT03639532 Phase 4
29 Impact of Supra-inguinal Fascia Iliaca Compartment Block on Postoperative Opioid Consumption in Total Hip Arthroplasty Interventions by Posterior Approach Recruiting NCT04574479 Phase 4 Multimodal analgesia and PCA morphine pump
30 Perioperative Antibiotic Prophylaxis in Patients Undergoing Elective Total Knee Arthroplasty: A Prospective, Randomized, Open-label, Controlled Multi-center Trial Recruiting NCT03283878 Phase 4 Cefazolin
31 Prevention of Postoperative Urinary Retention With Treatment of Tamsulosin 5 Days Prior to Lower Limb Arthroplasty Recruiting NCT03808155 Phase 4 Tamsulosin;Placebo Oral Tablet
32 Evaluating Hemidiaphragmatic Paralysis With Prolonged Neural Blockade From an Interscalene Brachial Plexus Block Recruiting NCT04209504 Phase 4 Ropivacaine;Bupivacaine
33 Effect of Combinations of Paracetamol, Ibuprofen, and Dexamethasone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty. The RECIPE Randomized Clinical Trial Recruiting NCT04123873 Phase 4 Paracetamol;Ibuprofen (400 mg x 4);Dexamethasone;Placebo oral tablet (x 4);Placebo IV (x 1)
34 Intraosseous Vancomycin in Primary Total Hip Arthroplasty - Designing a Protocol Recruiting NCT04042233 Phase 4 Experimental Intraosseous vancomycin 500mg in 250 mL NS;Standard IV administration of vancomycin
35 Effect of Duloxetine on Opioid Use After Total Knee Arthroplasty: A Double-blinded Randomized Control Trial Active, not recruiting NCT03271151 Phase 4 Cymbalta
36 Efficacy of Intra-articular Injection of Combined Hyaluronic Acid and Platelet-rich Plasma in Knee Degenerative Joint Disease Active, not recruiting NCT03211650 Phase 4 hyaluronic Acid + platelet-rich plasma;hyaluronic acid;platelet-rich plasma
37 Liposomal Bupivacaine Interscalene Nerve Block in Shoulder Arthroplasty: A Single Blinded Prospective Randomized Control Trial Active, not recruiting NCT03663283 Phase 4 Liposomal Bupivacaine;Bupivacaine Hydrochloride
38 The Effect of Tranexamic Acid on Calculated Total Blood Loss in Patients Undergoing Revision Shoulder Arthroplasty Not yet recruiting NCT04650698 Phase 4 Tranexamic acid
39 Effect of Nickel Sensitivity on Patient Reported Outcomes After Total Knee Arthroplasty Not yet recruiting NCT04058743 Phase 4
40 Neuroendocrine Changes Associated With Magnesium Sulfate Administration in Surgical Patients Not yet recruiting NCT04514731 Phase 4 Magnesium sulfate;Isotonic Saline
41 DURALOC® Option Ceramic-on-Ceramic Hip Prosthesis System PMA Post-approval Study Terminated NCT00546598 Phase 4
42 Randomised, Controlled, Prospective, Multi-Centre, Post Market Surveillance Study Comparing a Ceramic-on-Metal Bearing and a Metal-on-Metal Bearing in Subjects Requiring Primary Total Hip Arthroplasty for Non-Inflammatory Degenerative Joint Disease Terminated NCT00873444 Phase 4
43 A Randomized Multicentre Clinical Trial Comparing The Metal on Metal Hip System Versus The Metal on Highly Crossed Linked Polyethylene System Terminated NCT01422564 Phase 4
44 A Radiographic and Clinical Outcomes Study Evaluating map3® Cellular Allogeneic Bone Graft in Patients Undergoing Bone Grafting in the Foot/Ankle Terminated NCT02161016 Phase 4
45 Effect of Spinal Versus General Anesthesia on Cardiac and Renal Biomarker Levels in Hip and Knee Arthroplasty Surgery Terminated NCT03940651 Phase 4 Spinal Anesthesia;General Anesthetics
46 The Reverse Delta III Total Shoulder Prosthesis - Longerm Results in 98 Patients Withdrawn NCT01873651 Phase 4
47 Efficacy of Intraoperative Injections on Postoperative Pain Control During Total Hip Arthroplasty: A Prospective, Blinded, Randomized Controlled Study Withdrawn NCT03119038 Phase 4 Bupivicaine + epinephrine;Bupivacaine;Ropivacaine;Ketorolac;Clonidine Injection
48 Efficacy of Intra-articular NSAID Versus Corticosteroid in the Treatment of Shoulder and Knee Conditions: A Randomized, Double-Blind, Prospective Study Unknown status NCT03616340 Phase 3 Shoulder injection;knee injection
49 A Phase III Clinical Trial to Evaluate the Efficacy and Safety of Chondron (Autologus Chondrocyte) in Patients With Cartilage Defects in Their Ankle for 18 Months Unknown status NCT02537067 Phase 3 CHONDRON
50 Immune Effect of Dexmedetomidine as Immunomodulatory Anesthesic Agent in Patients Undergoing to Spinal Fusion: a Double-blind, Randomized and Placebo-controlled Clinical Trial Unknown status NCT02854904 Phase 2, Phase 3 Dexmedetomidine intervention;Placebo

Search NIH Clinical Center for Arthropathy

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Arthropathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Arthropathy:
BioSeed-C, a 3D chondrocyte graft for the treatment of articular cartilage defects
ChondroCelect, chondrocytes for treatment of cartilage knee defects
Chondrosphere (ACT3D-CS), articular chondrocyte spheroids for treatment of cartilage knee defects
DeNovo NT, particulated juvenile cartilage for cartilage repair
MACI, cultured chondrocytes for articular cartilage damage in joints
RevaFlex, engineered tissue graft of juvenile cartilage for cartilage repair
Embryonic/Adult Cultured Cells Related to Arthropathy:
Chondrocytes embedded in a 3D polymer scaffold (BioSeed-C) PMIDs: 21540360 19711090 17451597
Articular cartilage-derived cells (ChondroCelect)
Articular chondrocyte spheroids (Chondrosphere)
Matrix-induced autologous cultured chondrocytes (MACI) PMIDs: 22922521 21257846 19966108 16632362 20880476 23880403 19755063 15278206 16320051 19169789 22539536 22483735 24175609 24005872 22885840 12810965 23618699
Juvenile neocartilage (RevaFlex) PMIDs: 11603712 23465950 19880363 15742595 21828366 20025455 20423988 21439468

Cochrane evidence based reviews: joint diseases

Sources

Genetic Tests for Arthropathy

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Genetic tests related to Arthropathy:

# Genetic test Affiliating Genes
1 Arthropathy 29
Sources

Anatomical Context for Arthropathy

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The Foundational Model of Anatomy Ontology organs/tissues related to Arthropathy:

19
Joint

MalaCards organs/tissues related to Arthropathy:

40
Bone, Bone Marrow, Skin, Spinal Cord, Endothelial, Kidney, T Cells
Sources

Publications for Arthropathy

About this section

Articles related to Arthropathy:

(show top 50) (show all 10996)
# Title Authors PMID Year
1
[Bone and joint diseases in children. Phosphaturic hormone, FGF23, and bone metabolism]. 54 61
20513948 2010
2
Precocious bilateral hip joint osteoarthritis is a "form-fruste" of the arthropathy of hereditary haemochromatosis. 54 61
19942354 2010
3
Factor VIII requirement to maintain a target plasma level in the prophylactic treatment of severe hemophilia A: influences of variance in pharmacokinetics and treatment regimens. 54 61
19943875 2010
4
[Monoclonal antibodies in chronic autoimmune inflammatory diseases]. 54 61
20035687 2009
5
New insights into BMP-7 mediated osteoblastic differentiation of primary human mesenchymal stem cells. 54 61
19306956 2009
6
Adipokines in the skeleton: influence on cartilage function and joint degenerative diseases. 54 61
19240195 2009
7
Correlation of gene and mediator expression with clinical endpoints in an acute interleukin-1beta-driven model of joint pathology. 61 54
19010066 2009
8
Break-through bleeding in relation to predicted factor VIII levels in patients receiving prophylactic treatment for severe hemophilia A. 54 61
19143924 2009
9
[Knee ochronotic arthropathy and arthroscopic findings]. 54 61
19293619 2009
10
The combination of the biomarkers urinary C-terminal telopeptide of type II collagen, serum cartilage oligomeric matrix protein, and serum chondroitin sulfate 846 reflects cartilage damage in hemophilic arthropathy. 54 61
19116938 2009
11
Prevention of arthropathy: may it be extrapolated from patients without inhibitors to patients with inhibitors? 61 54
19134030 2008
12
Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis. 54 61
18759291 2008
13
Economic evaluation of major knee surgery with recombinant activated factor VII in hemophilia patients with high titer inhibitors and advanced knee arthropathy: exploratory results via literature-based modeling. 54 61
18234151 2008
14
[Genomic approaches to bone and joint diseases. Mutations of RANK, OPG and RANKL genes found in humans]. 61 54
18245890 2008
15
Joint diseases and matrix metalloproteinases: a role for MMP-13. 61 54
18289056 2008
16
The hand arthropathy of hereditary hemochromatosis is strongly associated with iron overload. 54 61
18061976 2008
17
The role of VWF for the success of immune tolerance induction. 54 61
18549910 2008
18
WISP3 suppresses insulin-like growth factor signaling in human chondrocytes. 61 54
17942216 2007
19
Basic fibroblast growth factor activates the MAPK and NFkappaB pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes. 61 54
17724016 2007
20
Comparing prophylaxis with episodic treatment in haemophilia A: implications for clinical practice. 61 54
17685917 2007
21
Effective therapy with anti-TNF-alpha in patients with psoriatic arthritis is associated with decreased levels of metalloproteinases and angiogenic cytokines in the sera and skin lesions. 54 61
17911474 2007
22
Cuff tear arthropathy: evidence of functional variation in pyrophosphate metabolism genes. 61 54
17563703 2007
23
The anesthetic management of children with neonatal-onset multi-system inflammatory disease. 61 54
17646489 2007
24
Osteochondral repair in synovial joints. 54 61
17414953 2007
25
Mutant WISP3 triggers the phenotype shift of articular chondrocytes by promoting sensitivity to IGF-1 hypothesis of spondyloepiphyseal dysplasia tarda with progressive arthropathy (SEDT-PA). 61 54
17363178 2007
26
Stimulation of osteoclast formation by inflammatory synovial fluid. 61 54
16642388 2006
27
Ochronotic rheumatism in Algeria: clinical, radiological, biological and molecular studies--a case study of 14 patients in 11 families. 54 61
16085442 2006
28
HFE gene mutations are associated with osteoarthritis in the index or middle finger metacarpophalangeal joints. 54 61
16583477 2006
29
A homozygous mutation in the lamin A/C gene associated with a novel syndrome of arthropathy, tendinous calcinosis, and progeroid features. 61 54
16278265 2006
30
Synovial fluid macrophages are capable of osteoclast formation and resorption. 54 61
16278818 2006
31
HFE mutations in the pathobiology of hemophilic arthropathy. 54 61
15802547 2005
32
Analysis of cartilage oligomeric matrix protein (COMP) degradation and synthesis in equine joint disease. 61 54
15651731 2005
33
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS): definition, semiology, prognosis, pathogenesis, treatment, and place relative to other periodic joint diseases. 61 54
15288852 2004
34
Simvastatin reduces MMP-3 level in interleukin 1beta stimulated human chondrocyte culture. 54 61
15194586 2004
35
Coagulation factors with improved properties for hemophilia gene therapy. 61 54
15118934 2004
36
Serum human cartilage glycoprotein 39 as a marker of arthritis associated with inflammatory bowel disease. 61 54
14644865 2003
37
Effect of propolis on human cartilage and chondrocytes. 54 61
12818355 2003
38
The Hemophilia Utilization Group Study (HUGS): determinants of costs of care in persons with haemophilia A. 54 61
12694525 2003
39
Osteoclasts, pro-inflammatory cytokines, RANK-L and bone remodeling in rheumatoid arthritis. 54 61
12700082 2003
40
Elevated levels of synovial fluid antibodies reactive with the small proteoglycans biglycan and decorin in patients with rheumatoid arthritis or other joint diseases. 54 61
12649398 2003
41
Vitreoretinopathy with phalangeal epiphyseal dysplasia, a type II collagenopathy resulting from a novel mutation in the C-propeptide region of the molecule. 61 54
12205109 2002
42
Hemophilic arthropathy. A scoring system for magnetic resonance imaging. 54 61
11960235 2002
43
Concentrations of cartilage oligomeric matrix protein in dogs with naturally developing and experimentally induced arthropathy. 61 54
11939326 2002
44
Clinical significance of cytokine determination in synovial fluid. 61 54
11890208 2002
45
Persistence of parvovirus B19 DNA in synovium of patients with haemophilic arthritis. 54 61
11536251 2001
46
Arthropathy in hereditary hemochromatosis. 54 61
11148720 2001
47
Synovial fluid matrix metalloproteinase-3 levels are increased in inflammatory arthritides whether erosive or not. 54 61
11136879 2000
48
Increased synovial fluid levels of interleukin-12, sCD25 and sTNF-RII/sTNF-RI ratio delineate a cytokine pattern characteristic of immune arthropathies. 61 54
11125312 2000
49
Synovial hyperplasia in HTLV-I associated arthropathy is induced by tumor necrosis factor-alpha produced by HTLV-I infected CD68+ cells. 61 54
10782809 2000
50
Specific expression of interleukin-1 beta in temporomandibular joints with internal derangement: correlation with clinical findings. 61 54
10519747 1999
Sources

Variations for Arthropathy

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Sources

Expression for Arthropathy

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Search GEO for disease gene expression data for Arthropathy.
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Pathways for Arthropathy

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Pathways related to Arthropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
IL6-mediated signaling events 1
Show member pathways
 11.59 TNFSF11 IL6 CRP
2
TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions 64
Show member pathways
 11.55 TNFSF11 TNFRSF11B TNF
3
Pertussis 36
11.49 TNF NLRP3 IL6
4
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.38 TNF MMP2 IL6
5
Lung fibrosis 1
11.34 TNF MMP2 IL6
6
Photodynamic therapy-induced AP-1 survival signaling. 1
11.21 TNF MMP2 IL6
7
Malaria 36
11.13 TNF IL6 COMP
8
amb2 Integrin signaling 1
11.01 TNF MMP2 IL6
9
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
10.58 TNFSF11 TNFRSF11B TNF IL6
10
Overview of nanoparticle effects 1
10.41 TNF IL6 CRP
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GO Terms for Arthropathy

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Cellular components related to Arthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 TNFSF11 TNFRSF11B TNF PRG4 NLRP3 MMP2
2 collagen-containing extracellular matrix GO:0062023 9.65 PRG4 MMP2 F9 COMP ACAN
3 extracellular matrix GO:0031012 9.55 TNFRSF11B MMP2 COMP CCN6 ACAN
4 extracellular space GO:0005615 9.44 TNFSF11 TNFRSF11B TNF MMP2 MICA IL6
5 MHC class I protein complex GO:0042612 9.37 HFE B2M
6 HFE-transferrin receptor complex GO:1990712 9.32 HFE B2M

Biological processes related to Arthropathy according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.91 TRPV4 TNFSF11 TNF IL6 HFE CRP
2 cytokine-mediated signaling pathway GO:0019221 9.88 TNFSF11 TNF MMP2 IL6 IL1RAPL2
3 immune response GO:0006955 9.88 TNFSF11 TNF PRG4 MICA IL6 B2M
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 TNFSF11 TNF NLRP3 IL6
5 skeletal system development GO:0001501 9.8 TNFRSF11B COMP ANKH ACAN
6 positive regulation of JNK cascade GO:0046330 9.77 TRPV4 TNFSF11 TNF
7 extracellular matrix organization GO:0030198 9.77 TNFRSF11B TNF MMP2 COMP ACAN
8 positive regulation of smooth muscle cell proliferation GO:0048661 9.75 TNF MMP2 IL6
9 positive regulation of interleukin-1 beta production GO:0032731 9.7 TNF NLRP3 IL6
10 positive regulation of neuroinflammatory response GO:0150078 9.61 TNF IL6
11 cellular response to nicotine GO:0071316 9.59 TNF B2M
12 negative regulation of receptor binding GO:1900121 9.58 HFE B2M
13 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.57 NLRP3 IL6
14 positive regulation of receptor binding GO:1900122 9.56 HFE B2M
15 cellular response to iron ion GO:0071281 9.55 HFE B2M
16 vascular endothelial growth factor production GO:0010573 9.54 TNF IL6
17 regulation of iron ion transport GO:0034756 9.46 HFE B2M
18 negative regulation of neurogenesis GO:0050768 9.33 TNF IL6 B2M
19 positive regulation of transferrin receptor binding GO:1904437 9.32 HFE B2M
20 positive regulation of ferrous iron binding GO:1904434 9.26 HFE B2M
21 negative regulation of lipid storage GO:0010888 9.13 TNF IL6 CRP
22 acute-phase response GO:0006953 8.92 IL6 HFE F8 CRP

Molecular functions related to Arthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 TNFSF11 TNFRSF11B TNF IL6
2 beta-2-microglobulin binding GO:0030881 8.62 MICA HFE
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Sources for Arthropathy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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