Aliases & Classifications for Arthropathy

MalaCards integrated aliases for Arthropathy:

Name: Arthropathy 12 29 55 15 72
Joint Ankylosis of the Pelvic Region and Thigh 12
Ankylosis of Joint of Pelvic Region and Thigh 12
Joint Ankylosis of the Ankle and/or Foot 12
Ankylosis of Joint of Ankle and/or Foot 12
Joint Ankylosis of the Shoulder Region 12
Ankylosis of Joint of Shoulder Region 12
Joint Ankylosis of the Ankle and Foot 12
Arthropathy Associated with Infection 72
Ankylosis of Joint of Multiple Sites 12
Ankylosis of Ankle and Foot Joint 12
Joint Ankylosis of the Lower Leg 12
Joint Ankylosis of the Upper Arm 12
Ankylosis of Joint of Lower Leg 12
Ankylosis of Joint of Upper Arm 12
Joint Ankylosis of the Forearm 12
Ankylosis of Joint of Forearm 12
Ankylosis of Lower Leg Joint 12
Ankylosis of Multiple Joints 12
Ankylosis of Upper Arm Joint 12
Joint Ankylosis of the Hand 12
Ankylosis of Forearm Joint 12
Ankylosis of Joint of Hand 12
Ankylosis of Hand Joint 12
Infectious Arthropathy 12
Joint Diseases 44
Joint Disease 17

Classifications:



External Ids:

Disease Ontology 12 DOID:381
MeSH 44 D007592
UMLS 72 C0022408 C0157749

Summaries for Arthropathy

Disease Ontology : 12 A bone disease that is located in the joint.

MalaCards based summary : Arthropathy, also known as joint ankylosis of the pelvic region and thigh, is related to reactive arthritis and hemophilic arthropathy, and has symptoms including joint stiffness, arthralgia and back pain. An important gene associated with Arthropathy is PRG4 (Proteoglycan 4), and among its related pathways/superpathways are Development Endothelin-1/EDNRA signaling and AGE-RAGE signaling pathway in diabetic complications. The drugs Prednisone and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and t cells, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 75 An arthropathy is a disease of a joint. Arthritis is a form of arthropathy that involves inflammation of... more...

Related Diseases for Arthropathy

Diseases in the Arthropathy family:

Transient Arthropathy

Diseases related to Arthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 896)
# Related Disease Score Top Affiliating Genes
1 reactive arthritis 33.4 TNF CRP COMP
2 hemophilic arthropathy 33.2 TNFSF11 TNFRSF11B HFE COMP
3 osteoarthritis 32.2 TNF PRG4 IL1B COMP ACAN
4 chondrocalcinosis 31.5 TNFRSF11B HFE ANKH
5 spondylitis 31.3 TNF MICA CRP
6 psoriatic arthritis 31.2 TNFSF11 TNFRSF11B TNF MICA IL1B CRP
7 multicentric reticulohistiocytosis 31.0 TNFSF11 TNFRSF11B
8 palindromic rheumatism 31.0 TNF IL1B CRP
9 periarthritis 30.8 B2M ANKH
10 juvenile rheumatoid arthritis 30.7 TNF IL1B CRP
11 exanthem 30.7 TNF NLRP3 CRP
12 carpal tunnel syndrome 30.7 IL1B B2M ACAN
13 rheumatoid arthritis 30.6 TNFSF11 TNFRSF11B TNF IL1B CRP COMP
14 pericarditis 30.5 TNF PRG4 IL1B CRP
15 spondyloarthropathy 1 30.4 TNFRSF11B TNF CRP B2M ANKH
16 rheumatic disease 30.3 TNFRSF11B TNF IL1B CRP
17 osteomyelitis 30.2 TNFSF11 TNF IL1B
18 cartilage disease 29.9 CRP COMP ACAN
19 prosthetic joint infection 29.8 TNFRSF11B IL1B
20 polyarticular onset juvenile idiopathic arthritis 29.8 TNFSF11 TNFRSF11B
21 intestinal disease 29.8 TNF IL1B CRP
22 uremia 29.8 TNFRSF11B CRP B2M
23 gastroenteritis 29.7 TNF IL1B CRP
24 chlamydia 29.7 TNF IL1B CRP
25 myeloma, multiple 29.6 TNFSF11 TNFRSF11B TNF CRP B2M
26 arthritis 29.6 TNFSF11 TNF MICA IL1B ANKH ACAN
27 adult-onset still's disease 29.6 TNF IL1B CRP
28 lyme disease 29.5 TNF IL1B CRP
29 bacterial infectious disease 29.5 TNF IL1B CRP
30 behcet syndrome 29.5 TNF MICA IL1B CRP
31 endosteal hyperostosis, autosomal dominant 29.5 TNFSF11 TNFRSF11B ANKH
32 sleep apnea 29.4 TNF IL1B CRP
33 familial mediterranean fever 29.3 TNF NLRP3 IL1B CRP
34 muckle-wells syndrome 29.3 NLRP3 IL1B CRP
35 synovitis 29.3 TNFSF11 TNFRSF11B TNF PRG4 IL1B CRP
36 peritonitis 29.1 TNF IL1B CRP B2M
37 root resorption 29.0 TNFSF11 TNFRSF11B IL1B
38 acquired immunodeficiency syndrome 29.0 TNF IL1B F9 B2M
39 meningitis 29.0 TNF NLRP3 IL1B CRP
40 bone disease 28.6 TNFSF11 TNFRSF11B TNF IL1B B2M ACAN
41 proteasome-associated autoinflammatory syndrome 1 28.5 TNF IL1RAPL2 IL1B CRP
42 wells syndrome 28.2 NLRP3 IL1RAPL2 IL1B CRP
43 bone inflammation disease 27.6 TNFSF11 TNFRSF11B TNF NLRP3 IL1B CRP
44 camptodactyly-arthropathy-coxa vara-pericarditis syndrome 12.9
45 multicentric osteolysis, nodulosis, and arthropathy 12.7
46 arthropathy, progressive pseudorheumatoid, of childhood 12.7
47 crystal arthropathies 12.7
48 digital arthropathy-brachydactyly, familial 12.7
49 neurogenic arthropathy 12.6
50 mseleni joint disease 12.5

Graphical network of the top 20 diseases related to Arthropathy:



Diseases related to Arthropathy

Symptoms & Phenotypes for Arthropathy

UMLS symptoms related to Arthropathy:


joint stiffness, arthralgia, back pain, sciatica, muscle cramp, metatarsalgia, joint symptom, musculoskeletal symptom, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm, other symptoms referable to joint, shoulder region, other symptoms referable to joint, upper arm, other symptoms referable to joint, forearm, other symptoms referable to joint, hand, other symptoms referable to joint, pelvic region and thigh, other symptoms referable to joint, lower leg, other symptoms referable to joint, ankle and foot, other symptoms referable to joint, other specified sites, other symptoms referable to joint, multiple sites, other symptoms referable to joint, site unspecified

MGI Mouse Phenotypes related to Arthropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.1 ANKH B2M COMP CRP F8 F9
2 cardiovascular system MP:0005385 10.07 ANKH B2M COMP CRP F9 IL1B
3 hematopoietic system MP:0005397 10.06 ANKH B2M F8 F9 HFE IL1B
4 immune system MP:0005387 10 ANKH B2M COMP CRP F8 F9
5 limbs/digits/tail MP:0005371 9.5 ANKH COMP HFE NLRP3 TNF TNFRSF11B
6 skeleton MP:0005390 9.32 ANKH COMP HFE HGD IL1B MMP2

Drugs & Therapeutics for Arthropathy

Drugs for Arthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 435)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2
Azithromycin Approved Phase 4 83905-01-5 447043 55185
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
5
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
6
Acetaminophen Approved Phase 4 103-90-2 1983
7
Morphine Approved, Investigational Phase 4 57-27-2 5288826
8
Remifentanil Approved Phase 4 132875-61-7 60815
9
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
10
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
11
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
12
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
13
Tranexamic Acid Approved Phase 4 1197-18-8 5526
14
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
15
Aminocaproic acid Approved, Investigational Phase 4 60-32-2 564
16
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
17
Levomilnacipran Approved, Investigational Phase 4 96847-54-0
18
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
19
tannic acid Approved Phase 4 1401-55-4
20
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
21
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
22
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
23
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
24
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 5281106 54677470
25
Aceclofenac Approved, Investigational Phase 4 89796-99-6
26
Etanercept Approved, Investigational Phase 4 185243-69-0
27
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
28
Prilocaine Approved Phase 4 721-50-6 4906
29
Cefazolin Approved Phase 4 25953-19-9 656510 33255
30
Adalimumab Approved Phase 4 331731-18-1 16219006
31
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
32
Abatacept Approved Phase 4 332348-12-6 10237
33
Apremilast Approved, Investigational Phase 4 608141-41-9 11561674
34
Certolizumab pegol Approved Phase 4 428863-50-7
35
Infliximab Approved Phase 4 170277-31-3
36
Allopurinol Approved Phase 4 315-30-0 2094
37
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
38
Norepinephrine Approved Phase 4 51-41-2 439260
39
Febuxostat Approved Phase 4 144060-53-7 134018
40
Sodium citrate Approved, Investigational Phase 4 68-04-2
41
Chromium Approved Phase 4 7440-47-3 27668
42
Cobalt Approved, Experimental Phase 4 7440-48-4 104729
43
Vancomycin Approved Phase 4 1404-90-6 441141 14969
44
Cefepime Approved, Investigational Phase 4 88040-23-7 5479537
45
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
46
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
47
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
48
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
49
Clonidine Approved Phase 4 4205-90-7 2803
50
Racepinephrine Approved Phase 4 329-65-7 838

Interventional clinical trials:

(show top 50) (show all 924)
# Name Status NCT ID Phase Drugs
1 Adalimumab to Mitigate Cardiovascular Risk in RA Patients With Well-Controlled Joint Disease Unknown status NCT01893996 Phase 4 Adalimumab;Placebo
2 Efficacy of Intra-articular Injection of Combined Hyaluronic Acid and Platelet-rich Plasma in Knee Degenerative Joint Disease Unknown status NCT03211650 Phase 4 hyaluronic Acid + platelet-rich plasma;hyaluronic acid;platelet-rich plasma
3 Subclinical Joint Bleeding in Irish Adults With Severe Haemophilia A on Personalised Prophylaxis Regimens Unknown status NCT02314325 Phase 4 ADVATE [Antihemophilic Factor (Recombinant)];ADVATE [Antihemophilic Factor (Recombinant)]
4 Targeting Synovitis in Early Rheumatoid Arthritis (TaSER). Intensive Management of Early Rheumatoid Arthritis Using Either Clinical or Musculoskeletal Ultrasound Assessment of Synovitis − a Randomised Study With Blinded Outcome Assessments Unknown status NCT00920478 Phase 4
5 Open Label Study of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
6 EVALUATION OF THE RELATIONSHIP BETWEEN EFFERVESCENT PARACETAMOL AND BLOOD PRESSURE. CLINICAL TRIAL. Unknown status NCT02514538 Phase 4 Non- effervescent Paracetamol kern;Effervescent paracetamol termalgin
7 A Randomized, Double-Blind, Two-Period Study to Evaluate the Safety and Efficacy of Etanercept on Skin and Joint Disease in Psoriasis Subjects With Psoriatic Arthritis. Completed NCT00245960 Phase 4 etanercept
8 Phase IV Study of Landmarks for Spinal Anesthesia Completed NCT02330185 Phase 4
9 Consequence of the Learning Curve in Direct Anterior Approach for Total Hip Replacement Completed NCT02645435 Phase 4
10 Viscosupplementation in Patients With Hemophilic Arthropathy Completed NCT01748201 Phase 4
11 Efficacy and Safety of the Infiltration of Autologous Plasma Rich in Growth Factors (PRGF) in the Symptomatic Treatment of Knee Osteoarthritis Completed NCT00782197 Phase 4
12 Pain After Total Knee Arthroplasty: a Comparison of Combined Continuous Adductor Canal Block With Infiltration of Local Anesthetic Between the Popliteal Artery and Capsule of the Knee Block Versus Continuous Adductor Canal Block Alone on Postoperative Analgesia Completed NCT03921034 Phase 4 Ropivacaine;Saline
13 Impact of Conservative Treatment by Custom-made Orthoses in Patients With Haemophilic Ankle Arthropathy Completed NCT00638001 Phase 4
14 Milnacipran for the Pain, Sensory Sensitization and Mood Changes in Knee Osteoarthritis Completed NCT01510457 Phase 4 Milnacipran;Placebo
15 Does Deep Neuromuscular Blockade Improve Operating Conditions During Total Hip Replacements? Completed NCT03219294 Phase 4 Vecuronium 0.1 mg/kg;Vecuronium 0.2mg/kg
16 Determining the Optimal Dose of Tranexamic Acid in Decreasing Blood Loss During Lower Extremity Total Joint Arthroplasty Completed NCT02584725 Phase 4 Tranexamic Acid
17 Fase IV Clinical Trial to Evaluate Chondroitin Sulphate Efficacy and Safety in Patients With Knee Osteoarthritis and Psoriasis Completed NCT00669123 Phase 4 Chondroitin sulphate;Placebo
18 A Prospective Study to Evaluate the Effect of rFVIII-FS in Different Prophylactic Regimens on Bleeding Events Frequency and Development of Arthropathy in Previously Treated and Minimally Treated Hemophilia A Pediatric Population. Completed NCT00632814 Phase 4 rFVIII-FS (Kogenate FS, BAY14-2222) 70 IU/kg, dosing once per week;rFVIII-FS (Kogenate FS, BAY14-2222), 70 IU/kg twice per week (30 IU/kg + 40 IU/kg);rFVIII-FS (Kogenate FS, BAY14-2222) 75 IU/kg, dosing three times per week (3 x 25 IU/kg)
19 Topical Application of Tranexamic Acid in Joint Arthroplasty Completed NCT01937559 Phase 4 Normal saline
20 Infrapatellar Nerve Block for Post-operative Analgesia for Knee Arthroscopy Completed NCT01279447 Phase 4 0.25% Bupivacaine;Normal Saline
21 Periarticular Injection With Bupivacaine For Post-Operative Pain Control In Total Knee Replacement: A Prospective Randomized Double-Blind Controlled Trial Completed NCT01364194 Phase 4 0.25% Bupivacaine;0.9% normal saline
22 A Prospective, Randomised, Uncontrolled, Single-Centre, Post-Market Surveillance Study To Evaluate The Performance Of SmartSet® HV and SmartSet® GHV Bone Cements In Primary Cemented Total Hip Arthroplasty(THA) Completed NCT00872066 Phase 4
23 A Double Blind Randomised Study Comparing Hyaluronic Acid, Corticosteroid and Placebo During Arthrocentesis for Temporomandibular Joint Dysfunction Completed NCT01524913 Phase 4 Hyaluronic acid;Corticosteroid;Lactated Ringers
24 Clinical Outcome With Attention to Functional Results One Year After Fixed or Mobile Bearing Total Knee Replacement in a Randomized Controlled Trial Completed NCT00822640 Phase 4
25 A Randomized Controlled Trial of Tranexamic Acid and ε-Aminocaproic Acid to Reduce Blood Loss Following Total Knee Arthroplasty Completed NCT01873768 Phase 4 Tranexamic Acid (TXA);ε-Aminocaproic Acid (EACA)
26 The Effect of Subsartorial Saphenous Block on Postoperative Pain Following Major Ankle and Hind Foot Surgery Completed NCT02697955 Phase 4 Bupivacaine-epinephrine
27 Five-Year Outcome of Ceramic on Ceramic Bearing Versus Ceramic on Crossfire® Highly Cross-Linked Polyethylene Bearing in Primary Total Hip Arthroplasty: A Randomized Trial Completed NCT01522014 Phase 4
28 A Prospective, Randomised, Controlled, Single Centre, Blinded Study of the Wear Characteristics of Two Polyethylene Bearing Surfaces, Enduron vs. Marathon Completed NCT00208442 Phase 4
29 Whole Body Vibration Compared to Conventional Physiotherapy in Patients With Coxarthrosis: a Randomized, Controlled Study Completed NCT01279174 Phase 4
30 Can Bone Erosions Heal in Adalimumab (Humira) Treated Rheumatoid Arthritis Patients. An Imaging Study Using Computed Tomography and Magnetic Resonance Imaging. Completed NCT00696059 Phase 4 Adalimumab (Humira)
31 Comparison of the Effect of a Single Shot Saphenous Block With Plain Bupivacaine vs. Protracted Bupivacaine Mixture as a Supplement to Continuous Sciatic Catheter After Major Ankle and Foot Surgery Completed NCT02346110 Phase 4 Bupivacaine-adrenaline;Dexamethasone
32 Is Ceramic-on-Ceramic THA Superior to Ceramic-on-Highly Cross-Linked Polyethylene THA in Patients Less Than 55 Years Old? Completed NCT03639532 Phase 4
33 Is Clinical Outcome of Robotic-Assisted TKA Better Than Conventional Manual TKA?Prospective, Randomized Study Completed NCT03659318 Phase 4
34 Efficacy and Tolerability of Mud Packs Therapy in Osteoarthritis of the Hands: a One Year Follow-up Completed NCT00773682 Phase 4
35 A Multicentre Double-blind Randomised Controlled Trial to Assess the Clinical- and Cost-effectiveness of Facet-joint Injections in Selected Patients With Non-specific Low Back Pain: a Feasibility Study Completed NCT03339362 Phase 4
36 Randomized Controlled Trial of Tranexamic Acid in Total Knee Arthroplasty: Intravenous vs. Topical Completed NCT01940523 Phase 4 Topical Tranexamic Acid;Intravenous Tranexamic Acid
37 Efficacy and Safety of Intra-Articular Injections of Durolane® in the Treatment of Osteoarthritis in the Knee Completed NCT00731289 Phase 4 hyaluronic acid;triamcinolone
38 A Phase IIIb Open-label run-in Double-blind, Placebo Controlled, Randomized Study to Evaluate the Safety/Efficacy of Certolizumab Pegol Administered Concomitantly With Stable-dose Methotrexate in Patients With Active Rheumatoid Arthritis. Completed NCT00580840 Phase 4 Certolizumab pegol;Certolizumab pegol
39 Functional Brain Imaging to Understand the Mechanisms of Pain Relief in Knee Osteoarthritis Completed NCT02208778 Phase 4 Duloxetine;Remifentanil;Placebo (for Remifentanil);Placebo (for Duloxetine)
40 Effectiveness of Triamcinolone Hexacetonide Intra-articular Injection in Interphalangeal Joints: a 12 Weeks Randomized Controlled Trial in Osteoarthritis Hand Patients Completed NCT02102620 Phase 4 Intra-articular injection with corticosteroid;Intra-articular injection with lidocaine
41 The Comparison of Knee Osteoarthritis Treatment With Single-dose of Bone Marrow Aspirate Concentrate, Single-dose of Leukocyte Rich Platelet Rich Plasma and 3 Injection of High Molecular Weight Hyaluronic Acid-A Randomized Clinical Trial Completed NCT03825133 Phase 4 Hyaluronic Acid
42 A Comparison of Tramadol/Acetaminophen Tablets Maintenance Versus NSAID Maintenance After Tramadol/Acetaminophen and NSAID Combination Therapy in Knee Osteoarthritis Patients: Multicenter, Randomized, Open Comparative Study Completed NCT00635349 Phase 4 Meloxicam;Aceclofenac;Tramadol Hydrochloride Plus Acetaminophen
43 Effect of Regenerative Injection Therapy on Function and Pain in Patients With Knee Osteoarthritis Completed NCT01206634 Phase 4
44 Comparison Between Single Shot Peripheral Nerve Block and Continuous Infusion Via a On-Q Pump in Extremity Fracture Operations: a Randomized Prospective Control Trial Completed NCT02280291 Phase 4 lidocaine;Propofol;Fentanyl;epinephrine,;bupivacaine
45 Analgesic Duration of Interscalene Block After Outpatient Arthroscopic Shoulder Surgery With Intravenous Dexamethasone, Dexmedetomidine or Their Combination: A Randomized Controlled Trial Completed NCT03270033 Phase 4 Dexamethasone;Dexmedetomidine
46 Efficacy and Cost Effectiveness of Standard Versus Pharmacokinetic Dosing During Factor VIII Prophylaxis in Adult Patients With Severe Haemophilia A Completed NCT02697370 Phase 4 Pharmacokinetic based dosage change
47 Randomized Controlled Doubleblind Pilot Study Comparing Analgosedation Concepts During Placement of Regional Anaesthesia With Either Fentanyl, Remifentanil, Clonidine, EMLA-Patch or Placebo in Regard of Pain Reduction. Recruiting NCT04026074 Phase 4 Fentanyl;Remifentanil;Clonidine;EMLA Cream;Placebo iv;Placebo salve
48 Liposomal Bupivacaine Interscalene Nerve Block in Shoulder Arthroplasty: A Single Blinded Prospective Randomized Control Trial Recruiting NCT03663283 Phase 4 Liposomal Bupivacaine;Bupivacaine Hydrochloride
49 The Efficacy of Ultrasound Guided Glenohumeral Joint Injections of Platelet Rich Plasma (PRP) Versus Hyaluronic Acid (HA) in the Treatment of Glenohumeral Osteoarthritis: a Randomized, Double-blind Control Trial Recruiting NCT02984228 Phase 4 Hyaluronic Acid
50 Perioperative Antibiotic Prophylaxis in Patients Undergoing Elective Total Knee Arthroplasty: A Prospective, Randomized, Open-label, Controlled Multi-center Trial Recruiting NCT03283878 Phase 4 Cefazolin

Search NIH Clinical Center for Arthropathy

Cochrane evidence based reviews: joint diseases

Genetic Tests for Arthropathy

Genetic tests related to Arthropathy:

# Genetic test Affiliating Genes
1 Arthropathy 29

Anatomical Context for Arthropathy

MalaCards organs/tissues related to Arthropathy:

41
Bone, Testes, T Cells, Skin, Bone Marrow, Spinal Cord, Liver

The Foundational Model of Anatomy Ontology organs/tissues related to Arthropathy:

19
Joint

Publications for Arthropathy

Articles related to Arthropathy:

(show top 50) (show all 10229)
# Title Authors PMID Year
1
[Bone and joint diseases in children. Phosphaturic hormone, FGF23, and bone metabolism]. 9 38
20513948 2010
2
Precocious bilateral hip joint osteoarthritis is a "form-fruste" of the arthropathy of hereditary haemochromatosis. 9 38
19942354 2010
3
Factor VIII requirement to maintain a target plasma level in the prophylactic treatment of severe hemophilia A: influences of variance in pharmacokinetics and treatment regimens. 9 38
19943875 2010
4
[Monoclonal antibodies in chronic autoimmune inflammatory diseases]. 9 38
20035687 2009
5
Adipokines in the skeleton: influence on cartilage function and joint degenerative diseases. 9 38
19240195 2009
6
New insights into BMP-7 mediated osteoblastic differentiation of primary human mesenchymal stem cells. 9 38
19306956 2009
7
Correlation of gene and mediator expression with clinical endpoints in an acute interleukin-1beta-driven model of joint pathology. 9 38
19010066 2009
8
Break-through bleeding in relation to predicted factor VIII levels in patients receiving prophylactic treatment for severe hemophilia A. 9 38
19143924 2009
9
[Knee ochronotic arthropathy and arthroscopic findings]. 9 38
19293619 2009
10
The combination of the biomarkers urinary C-terminal telopeptide of type II collagen, serum cartilage oligomeric matrix protein, and serum chondroitin sulfate 846 reflects cartilage damage in hemophilic arthropathy. 9 38
19116938 2009
11
Prevention of arthropathy: may it be extrapolated from patients without inhibitors to patients with inhibitors? 9 38
19134030 2008
12
Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis. 9 38
18759291 2008
13
Economic evaluation of major knee surgery with recombinant activated factor VII in hemophilia patients with high titer inhibitors and advanced knee arthropathy: exploratory results via literature-based modeling. 9 38
18234151 2008
14
Joint diseases and matrix metalloproteinases: a role for MMP-13. 9 38
18289056 2008
15
[Genomic approaches to bone and joint diseases. Mutations of RANK, OPG and RANKL genes found in humans]. 9 38
18245890 2008
16
The role of VWF for the success of immune tolerance induction. 9 38
18549910 2008
17
The hand arthropathy of hereditary hemochromatosis is strongly associated with iron overload. 9 38
18061976 2008
18
WISP3 suppresses insulin-like growth factor signaling in human chondrocytes. 9 38
17942216 2007
19
Basic fibroblast growth factor activates the MAPK and NFkappaB pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes. 9 38
17724016 2007
20
Effective therapy with anti-TNF-alpha in patients with psoriatic arthritis is associated with decreased levels of metalloproteinases and angiogenic cytokines in the sera and skin lesions. 9 38
17911474 2007
21
Cuff tear arthropathy: evidence of functional variation in pyrophosphate metabolism genes. 9 38
17563703 2007
22
Comparing prophylaxis with episodic treatment in haemophilia A: implications for clinical practice. 9 38
17685917 2007
23
The anesthetic management of children with neonatal-onset multi-system inflammatory disease. 9 38
17646489 2007
24
Osteochondral repair in synovial joints. 9 38
17414953 2007
25
Mutant WISP3 triggers the phenotype shift of articular chondrocytes by promoting sensitivity to IGF-1 hypothesis of spondyloepiphyseal dysplasia tarda with progressive arthropathy (SEDT-PA). 9 38
17363178 2007
26
Stimulation of osteoclast formation by inflammatory synovial fluid. 9 38
16642388 2006
27
Ochronotic rheumatism in Algeria: clinical, radiological, biological and molecular studies--a case study of 14 patients in 11 families. 9 38
16085442 2006
28
HFE gene mutations are associated with osteoarthritis in the index or middle finger metacarpophalangeal joints. 9 38
16583477 2006
29
A homozygous mutation in the lamin A/C gene associated with a novel syndrome of arthropathy, tendinous calcinosis, and progeroid features. 9 38
16278265 2006
30
Synovial fluid macrophages are capable of osteoclast formation and resorption. 9 38
16278818 2006
31
HFE mutations in the pathobiology of hemophilic arthropathy. 9 38
15802547 2005
32
Analysis of cartilage oligomeric matrix protein (COMP) degradation and synthesis in equine joint disease. 9 38
15651731 2005
33
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS): definition, semiology, prognosis, pathogenesis, treatment, and place relative to other periodic joint diseases. 9 38
15288852 2004
34
Simvastatin reduces MMP-3 level in interleukin 1beta stimulated human chondrocyte culture. 9 38
15194586 2004
35
Coagulation factors with improved properties for hemophilia gene therapy. 9 38
15118934 2004
36
Serum human cartilage glycoprotein 39 as a marker of arthritis associated with inflammatory bowel disease. 9 38
14644865 2003
37
Effect of propolis on human cartilage and chondrocytes. 9 38
12818355 2003
38
The Hemophilia Utilization Group Study (HUGS): determinants of costs of care in persons with haemophilia A. 9 38
12694525 2003
39
Osteoclasts, pro-inflammatory cytokines, RANK-L and bone remodeling in rheumatoid arthritis. 9 38
12700082 2003
40
Elevated levels of synovial fluid antibodies reactive with the small proteoglycans biglycan and decorin in patients with rheumatoid arthritis or other joint diseases. 9 38
12649398 2003
41
Vitreoretinopathy with phalangeal epiphyseal dysplasia, a type II collagenopathy resulting from a novel mutation in the C-propeptide region of the molecule. 9 38
12205109 2002
42
Concentrations of cartilage oligomeric matrix protein in dogs with naturally developing and experimentally induced arthropathy. 9 38
11939326 2002
43
Hemophilic arthropathy. A scoring system for magnetic resonance imaging. 9 38
11960235 2002
44
Clinical significance of cytokine determination in synovial fluid. 9 38
11890208 2002
45
Persistence of parvovirus B19 DNA in synovium of patients with haemophilic arthritis. 9 38
11536251 2001
46
Arthropathy in hereditary hemochromatosis. 9 38
11148720 2001
47
Synovial fluid matrix metalloproteinase-3 levels are increased in inflammatory arthritides whether erosive or not. 9 38
11136879 2000
48
Increased synovial fluid levels of interleukin-12, sCD25 and sTNF-RII/sTNF-RI ratio delineate a cytokine pattern characteristic of immune arthropathies. 9 38
11125312 2000
49
Synovial hyperplasia in HTLV-I associated arthropathy is induced by tumor necrosis factor-alpha produced by HTLV-I infected CD68+ cells. 9 38
10782809 2000
50
Specific expression of interleukin-1 beta in temporomandibular joints with internal derangement: correlation with clinical findings. 9 38
10519747 1999

Variations for Arthropathy

Expression for Arthropathy

Search GEO for disease gene expression data for Arthropathy.

Pathways for Arthropathy

Pathways related to Arthropathy according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.39 TRPV4 TNFSF11 TNFRSF11B MMP2 IL1B
2 11.72 TNF MMP2 IL1B
3 11.71 TNFSF11 TNF IL1B
4 11.7 TRPV4 TNF MMP2 IL1B
5 11.64 TNFSF11 TNF IL1B
6 11.56 TNFSF11 TNFRSF11B TNF IL1B
7 11.53 TNF NLRP3 IL1B
8
Show member pathways
11.43 TNF MMP2 IL1B
9 11.41 TNF MMP2 IL1B
10
Show member pathways
11.36 TNF MMP2 IL1B ACAN
11 11.23 TNF IL1B COMP
12
Show member pathways
11.13 TNFRSF11B TNF IL1B
13 10.81 TNFSF11 TNF PRG4 IL1B ACAN
14 10.68 TNFSF11 TNFRSF11B
15 10.58 TNFSF11 TNFRSF11B TNF IL1B

GO Terms for Arthropathy

Cellular components related to Arthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 TNFSF11 TNFRSF11B TNF PRG4 NLRP3 MMP2
2 collagen-containing extracellular matrix GO:0062023 9.67 PRG4 MMP2 COMP ACAN
3 extracellular matrix GO:0031012 9.55 TNFRSF11B MMP2 COMP CCN6 ACAN
4 extracellular space GO:0005615 9.44 TNFSF11 TNFRSF11B TNF MMP2 MICA IL1B
5 MHC class I protein complex GO:0042612 9.32 HFE B2M
6 HFE-transferrin receptor complex GO:1990712 9.26 HFE B2M

Biological processes related to Arthropathy according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.9 TNFRSF11B TNF COMP ACAN
2 skeletal system development GO:0001501 9.81 TNFRSF11B COMP ANKH ACAN
3 defense response to Gram-positive bacterium GO:0050830 9.8 TNF NLRP3 CRP
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 TNFSF11 TNF NLRP3 IL1B
5 tumor necrosis factor-mediated signaling pathway GO:0033209 9.78 TNFSF11 TNFRSF11B TNF
6 cytokine-mediated signaling pathway GO:0019221 9.77 TNFSF11 TNF MMP2 IL1RAPL2 IL1B
7 regulation of osteoclast differentiation GO:0045670 9.64 TNFSF11 TNF
8 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 TNF IL1B
9 positive regulation of gene expression GO:0010628 9.63 TRPV4 TNFSF11 TNF IL1B HFE CRP
10 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.62 TRPV4 IL1B
11 negative regulation of lipid storage GO:0010888 9.61 TNF CRP
12 acute-phase response GO:0006953 9.61 HFE F8 CRP
13 positive regulation of chemokine biosynthetic process GO:0045080 9.59 TNF IL1B
14 regulation of establishment of endothelial barrier GO:1903140 9.58 TNF IL1B
15 positive regulation of receptor binding GO:1900122 9.58 HFE B2M
16 negative regulation of receptor binding GO:1900121 9.57 HFE B2M
17 cellular response to iron ion GO:0071281 9.56 HFE B2M
18 positive regulation of neuroinflammatory response GO:0150078 9.55 TNF IL1B
19 positive regulation of fever generation GO:0031622 9.54 TNF IL1B
20 interleukin-1 beta production GO:0032611 9.52 NLRP3 IL1B
21 sequestering of triglyceride GO:0030730 9.48 TNF IL1B
22 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 TNF IL1B
23 susceptibility to natural killer cell mediated cytotoxicity GO:0042271 9.32 MICA
24 positive regulation of transferrin receptor binding GO:1904437 9.32 HFE B2M
25 positive regulation of ferrous iron binding GO:1904434 9.26 HFE B2M
26 positive regulation of JNK cascade GO:0046330 9.26 TRPV4 TNFSF11 TNF IL1B
27 chronic inflammatory response to antigenic stimulus GO:0002439 9.16 TNF
28 immune response GO:0006955 9.1 TNFSF11 TNF PRG4 MICA IL1B B2M

Molecular functions related to Arthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 TNFSF11 TNFRSF11B TNF IL1B
2 natural killer cell lectin-like receptor binding GO:0046703 8.85 MICA
3 beta-2-microglobulin binding GO:0030881 8.62 MICA HFE

Sources for Arthropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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