MCID: ART006
MIFTS: 43

Arthus Reaction

Categories: Cardiovascular diseases, Immune diseases

Aliases & Classifications for Arthus Reaction

MalaCards integrated aliases for Arthus Reaction:

Name: Arthus Reaction 12 56 45 15 17 74
Arthus Type Urticaria 12
Arthus Phenomenon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1556
ICD9CM 36 995.21
MeSH 45 D001183
NCIt 51 C34400
SNOMED-CT 69 29548007
ICD10 34 T78.41
UMLS 74 C0003907

Summaries for Arthus Reaction

Disease Ontology : 12 A hypersensitivity reaction type III disease that is characterized by local vasculitis, has symptom pain, edema, hemorrhage, or necrosis, and has material basis in deposition of antigen-antibody immune complexes in vascular or serosal walls.

MalaCards based summary : Arthus Reaction, also known as arthus type urticaria, is related to shwartzman phenomenon and vasculitis, and has symptoms including pain An important gene associated with Arthus Reaction is SELL (Selectin L), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Immunologic Factors and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and neutrophil, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 77 In immunology, the Arthus reaction (/ˌɑːrˈtjuːs/) is a type of local type III hypersensitivity reaction.... more...

Related Diseases for Arthus Reaction

Diseases related to Arthus Reaction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 shwartzman phenomenon 30.6 ICAM1 TNF
2 vasculitis 30.0 ELANE ICAM1 SELL TNF
3 pleurisy 29.7 ALOX5 ICAM1 SELL TNF
4 asthma 29.3 ALOX5 ELANE ICAM1 SELL TNF
5 glomerulonephritis 29.2 CD46 CR1 ICAM1 MIF
6 toxicodendron dermatitis 10.3 ICAM1 SELL
7 plummer's disease 10.3 ICAM1 SELL
8 leukostasis 10.3 ICAM1 SELL
9 leukocyte adhesion deficiency, type i 10.3 ICAM1 SELL
10 chronic venous insufficiency 10.3 ICAM1 SELL
11 retinitis pigmentosa 60 10.3 SELL TNF
12 venous insufficiency 10.3 ICAM1 SELL
13 granulocytopenia 10.3 SELL TNF
14 actinic prurigo 10.3 ICAM1 TNF
15 hypersensitivity reaction type iii disease 10.3 ICAM1 TNF
16 poliomyelitis 10.3 ICAM1 TNF
17 lichen disease 10.3 ICAM1 TNF
18 erythema multiforme 10.2 ICAM1 TNF
19 plasmodium vivax malaria 10.2 ICAM1 TNF
20 extrinsic cardiomyopathy 10.2 ICAM1 TNF
21 cutaneous lupus erythematosus 10.2 ICAM1 TNF
22 autoimmune uveitis 10.2 ICAM1 TNF
23 rapidly progressive glomerulonephritis 10.2 ELANE ICAM1
24 nose disease 10.2 ICAM1 TNF
25 primary progressive multiple sclerosis 10.2 ICAM1 TNF
26 tuberculous meningitis 10.2 ALOX5 TNF
27 farmer's lung 10.2 ELANE TNF
28 pustular psoriasis 10.2 ELANE TNF
29 idiopathic achalasia 10.2 NOS2 TNF
30 mycetoma 10.2 CR1 NOS2
31 bronchopulmonary dysplasia 10.2 ELANE SELL
32 erysipelas 10.2 ELANE TNF
33 dystrophinopathies 10.2 NOS2 TNF
34 crohn's colitis 10.2 NOS2 TNF
35 eales disease 10.2 NOS2 TNF
36 legionellosis 10.1 CR1 TNF
37 pustulosis palmaris et plantaris 10.1 ELANE TNF
38 systemic onset juvenile idiopathic arthritis 10.1 MIF TNF
39 hepatitis 10.1
40 hepatitis b 10.1
41 thrombocytopenia 10.1
42 hepatopulmonary syndrome 10.1 NOS2 TNF
43 acute respiratory distress syndrome 10.1 ELANE TNF
44 parasitic protozoa infectious disease 10.1 ICAM1 TNF
45 oligoarticular juvenile idiopathic arthritis 10.1 MIF TNF
46 alopecia areata 10.1 ICAM1 TNF
47 adult-onset still's disease 10.1 MIF TNF
48 pulmonary sarcoidosis 10.1 ICAM1 TNF
49 adult respiratory distress syndrome 10.0 ELANE TNF
50 variola minor 10.0 CD46 CR1

Graphical network of the top 20 diseases related to Arthus Reaction:



Diseases related to Arthus Reaction

Symptoms & Phenotypes for Arthus Reaction

Symptoms:

12
  • pain

MGI Mouse Phenotypes related to Arthus Reaction:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 ALOX5 CD46 ICAM1 NOS2 SELL TNF
2 hematopoietic system MP:0005397 9.7 ALOX5 ELANE ICAM1 MIF NOS2 SELL
3 immune system MP:0005387 9.5 ALOX5 ELANE ICAM1 MIF NOS2 SELL
4 neoplasm MP:0002006 9.1 ELANE ICAM1 MIF NOS2 SELL TNF

Drugs & Therapeutics for Arthus Reaction

Drugs for Arthus Reaction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 4
2 Vaccines Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Safety and Immunogenicity Study of Rotavirus Vaccine Simultaneously Vaccinated With MR or MMR Vaccine Unknown status NCT02153866 Phase 4

Search NIH Clinical Center for Arthus Reaction

Cochrane evidence based reviews: arthus reaction

Genetic Tests for Arthus Reaction

Anatomical Context for Arthus Reaction

MalaCards organs/tissues related to Arthus Reaction:

42
Skin, Lung, Neutrophil, Testes, Skeletal Muscle, Kidney, Eye

Publications for Arthus Reaction

Articles related to Arthus Reaction:

(show top 50) (show all 162)
# Title Authors Year
1
Arthus Reaction. ( 30826085 )
2019
2
The vaccines-associated Arthus reaction. ( 30945978 )
2019
3
Anti-TWEAK monoclonal antibodies reduce vascular damage and leucocyte infiltration in a mouse model of cutaneous reverse passive Arthus reaction. ( 27753135 )
2016
4
Diagnosis of Mesobuthus eupeus envenomation by skin test: reverse passive Arthus reaction. ( 24269785 )
2014
5
Isoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model. ( 23096126 )
2013
6
Exogenous application of hydrogen sulfide donor attenuates inflammatory reactions through the L-selectin-involved pathway in the cutaneous reverse passive Arthus reaction. ( 23381473 )
2013
7
Metabolomic investigation of Arthus reaction in a rat model using proton nuclear magnetic resonance (1H NMR) spectroscopy and rapid resolution liquid chromatography (RRLC). ( 23511749 )
2013
8
Paeoniflorin suppresses vascular damage and the expression of E-selectin and ICAM-1 in a mouse model of cutaneous Arthus reaction. ( 23800055 )
2013
9
Basophils and mast cells play critical roles for leukocyte recruitment in IgE-mediated cutaneous reverse passive Arthus reaction. ( 22784785 )
2012
10
Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction. ( 20008131 )
2010
11
Migration inhibitory factor (MIF) released by macrophages upon recognition of immune complexes is critical to inflammation in Arthus reaction. ( 19188484 )
2009
12
Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction. ( 19389931 )
2009
13
Involvement of gaseous low molecular monoxides in the cutaneous reverse passive Arthus reaction: cytoprotective action of carbon monoxide. ( 18505425 )
2008
14
Effects of cholinotropic and cytostatic drugs on the development of Arthus reaction. ( 19513373 )
2008
15
Intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 cooperatively contribute to the cutaneous Arthus reaction. ( 17299025 )
2007
16
Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation. ( 15728518 )
2005
17
Effect of nicotine-induced corticosterone elevation on nitric oxide production in the passive skin arthus reaction in rats. ( 14745115 )
2004
18
Role of C-C chemokine receptors 1 and 5 and CCL3/macrophage inflammatory protein-1alpha in the cutaneous Arthus reaction: possible attenuation of their inhibitory effects by compensatory chemokine production. ( 15517609 )
2004
19
Nicotine-induced inflammatory decreasing effect on passive skin arthus reaction in paraventricular nucleus-lesioned wistar rats. ( 12753427 )
2003
20
The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression. ( 11884469 )
2002
21
Arthus reaction to lepirudin, a new recombinant hirudin, and delayed-type hypersensitivity to several heparins and heparinoids, with tolerance to its intravenous administration. ( 11918584 )
2002
22
New functions of neutrophils in the arthus reaction: expression of tissue factor, the clotting initiator, and fibrinolysis by elastase. ( 12379763 )
2002
23
Lyn is essential for fcgamma receptor III-mediated systemic anaphylaxis but not for the Arthus reaction. ( 11238587 )
2001
24
Apoptosis mediates decrease in cellularity during the regression of Arthus reaction in cornea. ( 11316727 )
2001
25
Arthus reaction to recombinant hepatitis B virus vaccine. ( 11512098 )
2001
26
Transcription factor decoy oligodeoxynucleotides to nuclear factor-kappaB inhibit reverse passive Arthus reaction in rat. ( 11692225 )
2001
27
The Arthus reaction in rodents: species-specific requirement of complement. ( 10605043 )
2000
28
A codominant role of Fc gamma RI/III and C5aR in the reverse Arthus reaction. ( 10623857 )
2000
29
Contribution of B(2) receptors for bradykinin in arthus reaction-induced plasma extravasation in wild-type or B(2) transgenic knockout mice. ( 10780980 )
2000
30
A new small molecule C5a receptor antagonist inhibits the reverse-passive Arthus reaction and endotoxic shock in rats. ( 10843715 )
2000
31
On the role of complement and Fc gamma-receptors in the Arthus reaction. ( 10698344 )
1999
32
Streptococcal and staphylococcal superantigen-induced lymphocytic arteritis in a local type experimental model: comparison with acute vasculitis in the Arthus reaction. ( 9452132 )
1998
33
In vivo inflammatory response to a prototypic B cell superantigen: elicitation of an Arthus reaction by staphylococcal protein A. ( 9605120 )
1998
34
P-selectin requirement for neutrophil accumulation and injury in the direct passive Arthus reaction. ( 9649192 )
1998
35
Nitric oxide inhibits neutrophil infiltration in the reverse passive arthus reaction in rat skin. ( 9826072 )
1998
36
Roles of endothelins and their receptors in immune complex-induced/polymorphonuclear-mediated lung injury (reversed passive arthus reaction) in CD-1 mice. ( 9918750 )
1998
37
Histochemical investigations of the skeletal muscle fibres during the reversed passive Arthus reaction in guinea pigs. ( 9151106 )
1997
38
Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor. ( 9271590 )
1997
39
Light and electron microscopic examination of skeletal muscles in the reversed passive Arthus reaction. ( 9278109 )
1997
40
Erythrogenic toxin-induced arteritis in a rabbit ear model. Comparison with Arthus reaction angiitis. ( 9331774 )
1997
41
ICAM-1 mediates leukocyte-endothelium adhesive interactions in the reversed passive Arthus reaction. ( 8604010 )
1996
42
Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. ( 8769481 )
1996
43
A dominant role for mast cell Fc receptors in the Arthus reaction. ( 8885871 )
1996
44
Role of P-selectin in the early stage of the Arthus reaction. ( 8886860 )
1996
45
The role of CD11/CD18 integrins in the reverse passive Arthus reaction in rat dermal tissue. ( 8603998 )
1996
46
The role of ICAM-1 in the reverse passive Arthus reaction induced pleurisy in the rat. ( 8548405 )
1995
47
Studies on the mechanisms involved in the inflammatory response in a reversed passive Arthus reaction in guinea-pig skin: contribution of neutrophils and endogenous mediators. ( 7889293 )
1994
48
Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade. ( 8066448 )
1994
49
Neutrophil elicitation in the reverse passive Arthus reaction. Complement-dependent and -independent mast cell involvement. ( 8301139 )
1994
50
Recombinant soluble human Fc gamma RII: production, characterization, and inhibition of the Arthus reaction. ( 8228810 )
1993

Variations for Arthus Reaction

Expression for Arthus Reaction

Search GEO for disease gene expression data for Arthus Reaction.

Pathways for Arthus Reaction

GO Terms for Arthus Reaction

Cellular components related to Arthus Reaction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.35 CD46 CR1 ICAM1 SELL TNF
2 cell surface GO:0009986 9.17 CD46 CR1 ELANE ICAM1 MIF SELL

Biological processes related to Arthus Reaction according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.76 ELANE NOS2 TNF
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.75 ICAM1 MIF TNF
3 regulation of cell proliferation GO:0042127 9.72 MIF NOS2 TNF
4 response to lipopolysaccharide GO:0032496 9.71 ELANE ICAM1 NOS2
5 cytokine-mediated signaling pathway GO:0019221 9.71 ALOX5 ICAM1 NOS2 TNF
6 cellular response to lipopolysaccharide GO:0071222 9.7 ICAM1 NOS2 TNF
7 viral entry into host cell GO:0046718 9.61 CD46 CR1 ICAM1
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.59 ICAM1 TNF
9 cell aging GO:0007569 9.57 ICAM1 MIF
10 positive regulation of cytokine secretion GO:0050715 9.56 MIF TNF
11 leukocyte tethering or rolling GO:0050901 9.51 SELL TNF
12 negative regulation of growth of symbiont in host GO:0044130 9.49 ELANE TNF
13 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.48 ELANE TNF
14 acute inflammatory response to antigenic stimulus GO:0002438 9.46 ELANE ICAM1
15 negative regulation of gene expression GO:0010629 9.46 CD46 MIF NOS2 TNF
16 positive regulation of MAP kinase activity GO:0043406 9.43 ELANE MIF TNF
17 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.37 ICAM1 TNF
18 neutrophil degranulation GO:0043312 9.35 ALOX5 CR1 ELANE MIF SELL
19 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.32 MIF TNF
20 leukocyte migration GO:0050900 9.02 ELANE ICAM1 MIF SELL TNF

Molecular functions related to Arthus Reaction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.13 CD46 CR1 ICAM1
2 protease binding GO:0002020 8.92 ELANE MIF SELL TNF

Sources for Arthus Reaction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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