MCID: ART006
MIFTS: 40

Arthus Reaction

Categories: Cardiovascular diseases, Immune diseases

Aliases & Classifications for Arthus Reaction

MalaCards integrated aliases for Arthus Reaction:

Name: Arthus Reaction 12 54 44 15 17 70
Arthus Type Urticaria 12
Arthus Phenomenon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1556
ICD9CM 34 995.21
MeSH 44 D001183
NCIt 50 C34400
SNOMED-CT 67 402413008
ICD10 32 T78.41
UMLS 70 C0003907

Summaries for Arthus Reaction

Disease Ontology : 12 A hypersensitivity reaction type III disease that is characterized by local vasculitis, has symptom pain, edema, hemorrhage, or necrosis, and has material basis in deposition of antigen-antibody immune complexes in vascular or serosal walls.

MalaCards based summary : Arthus Reaction, also known as arthus type urticaria, is related to vasculitis and shwartzman phenomenon, and has symptoms including pain An important gene associated with Arthus Reaction is SELL (Selectin L), and among its related pathways/superpathways are Innate Immune System and RANK Signaling in Osteoclasts. Affiliated tissues include skin, neutrophil and lung, and related phenotypes are hematopoietic system and cellular

Wikipedia : 73 In immunology, the Arthus reaction (/ˌɑːrˈtjuːs/) is a type of local type III hypersensitivity reaction.... more...

Related Diseases for Arthus Reaction

Diseases related to Arthus Reaction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 240)
# Related Disease Score Top Affiliating Genes
1 vasculitis 30.7 TNF SELL ICAM1 ELANE
2 shwartzman phenomenon 30.6 TNF ICAM1
3 pleurisy 30.6 TNF SELL ICAM1 ALOX5
4 toxic shock syndrome 30.4 TNF NOS2 MIF
5 erythema nodosum 30.2 TNF SELL MIF ICAM1
6 otitis media 29.8 TNF ICAM1 ALB
7 extrinsic allergic alveolitis 29.7 SELL ELANE ALB
8 bacterial pneumonia 29.7 TNF ELANE ALB
9 bronchitis 29.6 TNF ELANE ALB
10 meningitis 29.1 TNF ICAM1 FCGR2A CD46 ALB
11 glomerulonephritis 29.1 NOS2 MIF ICAM1 ELANE CR1 CD46
12 peritonitis 28.9 TNF ICAM1 FCGR1A ELANE CR1 ALB
13 proteasome-associated autoinflammatory syndrome 1 28.9 TNF SELL NOS2 ICAM1 ELANE ALOX5
14 kawasaki disease 28.9 TNF SELL FCGR2B FCGR2A ELANE ALB
15 thrombocytopenia 28.4 TNF SELL ICAM1 FCGR2B FCGR2A FCGR1A
16 hypersensitivity reaction type iii disease 28.3 TNF FCGR2B FCGR2A FCGR1A C5AR1 ALB
17 allergic disease 10.4
18 type 1 diabetes mellitus 23 10.4 TNF SELL
19 actinic prurigo 10.3 TNF ICAM1
20 systemic onset juvenile idiopathic arthritis 10.3 TNF MIF
21 spotted fever rickettsiosis 10.3 TNF NOS2
22 mycobacterium abscessus 10.3 TNF HMOX1
23 anoxia 10.3 NOS2 ICAM1
24 toxicodendron dermatitis 10.3 TNF SELL ICAM1
25 leukostasis 10.3 TNF SELL ICAM1
26 pustular psoriasis 10.3 TNF ELANE
27 dystrophinopathies 10.3 TNF NOS2
28 primary progressive multiple sclerosis 10.3 TNF SELL ICAM1
29 rheumatoid vasculitis 10.3 TNF MIF ICAM1
30 plummer's disease 10.3 SELL ICAM1
31 cerebral aneurysms 10.3 HMOX1 ELANE
32 enterocolitis 10.2 TNF CD46
33 eales disease 10.2 TNF NOS2
34 lepromatous leprosy 10.2 TNF MIF ICAM1
35 conjunctivitis 10.2 TNF ICAM1 HRH1
36 cardiac rupture 10.2 TNF ELANE
37 cerebritis 10.2 TNF C5AR1
38 peripheral artery disease 10.2 TNF ICAM1 HMOX1
39 allergic conjunctivitis 10.2 TNF ICAM1 HRH1
40 contact dermatitis 10.2 TNF SELL ICAM1
41 tungiasis 10.2 TNF MIF
42 allergic contact dermatitis 10.2 TNF SELL ICAM1
43 mycetoma 10.2 NOS2 CR1
44 farmer's lung 10.2 TNF ELANE
45 tuberculous meningitis 10.2 TNF ALOX5
46 acute hemorrhagic encephalitis 10.2 ICAM1 CD46
47 granulocytopenia 10.2 TNF SELL
48 hydrops, lactic acidosis, and sideroblastic anemia 10.2
49 pertussis 10.2
50 cystitis 10.2 TNF NOS2 ICAM1

Graphical network of the top 20 diseases related to Arthus Reaction:



Diseases related to Arthus Reaction

Symptoms & Phenotypes for Arthus Reaction

Symptoms:

12
  • pain

MGI Mouse Phenotypes related to Arthus Reaction:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 ALOX5 C5AR1 ELANE FCGR1A FCGR2A FCGR2B
2 cellular MP:0005384 10.11 ALB ALOX5 C5AR1 FCGR1A FCGR2B HMOX1
3 homeostasis/metabolism MP:0005376 10.07 ALB ALOX5 C5AR1 ELANE FCGR2A FCGR2B
4 immune system MP:0005387 10 ALB ALOX5 C5AR1 ELANE FCGR1A FCGR2A
5 liver/biliary system MP:0005370 9.5 ALB FCGR2B HMOX1 HRH1 NOS2 SELL
6 neoplasm MP:0002006 9.17 ALB ELANE ICAM1 MIF NOS2 SELL

Drugs & Therapeutics for Arthus Reaction

Search Clinical Trials , NIH Clinical Center for Arthus Reaction

Cochrane evidence based reviews: arthus reaction

Genetic Tests for Arthus Reaction

Anatomical Context for Arthus Reaction

MalaCards organs/tissues related to Arthus Reaction:

40
Skin, Neutrophil, Lung, Eye, Heart, Endothelial, Brain

Publications for Arthus Reaction

Articles related to Arthus Reaction:

(show top 50) (show all 509)
# Title Authors PMID Year
1
Protective effect of membrane cofactor protein against complement-dependent injury. 61 54
16038633 2005
2
P-selectin glycoprotein ligand-1 is required for the development of cutaneous vasculitis induced by immune complex deposition. 54 61
15123773 2004
3
New functions of neutrophils in the arthus reaction: expression of tissue factor, the clotting initiator, and fibrinolysis by elastase. 54 61
12379763 2002
4
The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression. 61 54
11884469 2002
5
Preclinical Efficacy and Anti-Inflammatory Mechanisms of Action of the Bruton Tyrosine Kinase Inhibitor Rilzabrutinib for Immune-Mediated Disease. 61
33674445 2021
6
Immunostimulatory and anti-allergic potential of novel heterotrimeric lectin from seeds of Zizyphus mauritiana Lam. 61
33428960 2021
7
Inhibitory role of interleukin-10 in the cutaneous reverse Arthus reaction. 61
33063335 2021
8
In Vivo Functions of Mouse Neutrophils Derived from HoxB8-Transduced Conditionally Immortalized Myeloid Progenitors. 61
33310871 2021
9
Arthus Reaction as an Adverse Event Following Tdap Vaccination. 61
32674495 2020
10
The reversed passive Arthus reaction as a model for investigating the mechanisms of inflammation-associated hemostasis. 61
32105152 2020
11
CD22 and CD72 cooperatively contribute to the development of the reverse Arthus reaction model. 61
31262443 2019
12
A preclinical study-systemic evaluation of safety on mesenchymal stem cells derived from human gingiva tissue. 61
31196163 2019
13
Arthus Reaction. 61
30826085 2019
14
Vascular fibrinoid necrosis in the urinary bladder of ketamine abusers: A new finding that may provide a clue to the pathogenesis of ketamine-induced vesicopathy. 61
29527818 2019
15
The vaccines-associated Arthus reaction. 61
30945978 2019
16
Enhancement of cancer invasion and growth via the C5a-C5a receptor system: Implications for cancer promotion by autoimmune diseases and association with cervical cancer invasion. 61
30655847 2019
17
Sphingosine 1-Phosphate Receptor 1 Signaling Maintains Endothelial Cell Barrier Function and Protects Against Immune Complex-Induced Vascular Injury. 61
29781582 2018
18
Exacerbated Immune Complex-Mediated Vascular Injury in Mice with Heterozygous Deficiency of Aryl Hydrocarbon Receptor through Upregulation of Fcγ Receptor III Expression on Macrophages. 61
29605671 2018
19
TLT-1-CONTROLS EARLY THROMBUS FORMATION AND STABILITY BY FACILITATING AIIBB3 OUTSIDE-IN SIGNALING IN MICE. 61
30931337 2018
20
The Pyrazole Derivative BTP2 Attenuates IgG Immune Complex-induced Inflammation. 61
28852968 2018
21
Modulation of immunocyte functions by a mucin-specific lectin from Aspergillus gorakhpurensis. 61
28315765 2017
22
In vivo enzymatic modulation of IgG antibodies prevents immune complex-dependent skin injury. 61
27512946 2017
23
Immunomodulatory and therapeutic potential of a mucin-specific mycelial lectin from Aspergillus panamensis. 61
27993654 2017
24
EVALUATION OF THE ANTI-INFLAMMATORY CAPACITY OF BETA-SITOSTEROL IN RODENT ASSAYS. 61
28480389 2017
25
Anti-TWEAK monoclonal antibodies reduce vascular damage and leucocyte infiltration in a mouse model of cutaneous reverse passive Arthus reaction. 61
27753135 2016
26
A genetically-engineered von Willebrand disease type 2B mouse model displays defects in hemostasis and inflammation. 61
27212476 2016
27
Neutrophils Self-Regulate Immune Complex-Mediated Cutaneous Inflammation through CXCL2. 61
26802238 2016
28
CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis. 61
26404464 2015
29
Anti-allergic and anti-inflammatory properties of Zizyphus mauritiana root bark. 61
26189881 2015
30
The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment. 61
25225462 2014
31
β7 Integrin controls mast cell recruitment, whereas αE integrin modulates the number and function of CD8+ T cells in immune complex-mediated tissue injury. 61
24670804 2014
32
Occurrence of congenital cerebral theileriosis in a newborn twin Holstein calves in Iran: Case report. 61
25568725 2014
33
Diagnosis of Mesobuthus eupeus envenomation by skin test: reverse passive Arthus reaction. 61
24269785 2014
34
Is MC1 dispensable for regulation of cutaneous inflammatory and immune responses? 61
24131319 2013
35
Cholinergic receptors modulate immune complex-induced inflammation in vitro and in vivo. 61
23851693 2013
36
Paeoniflorin suppresses vascular damage and the expression of E-selectin and ICAM-1 in a mouse model of cutaneous Arthus reaction. 61
23800055 2013
37
Staphylococcus aureus formyl peptide receptor-like 1 inhibitor (FLIPr) and its homologue FLIPr-like are potent FcγR antagonists that inhibit IgG-mediated effector functions. 61
23740955 2013
38
Metabolomic investigation of Arthus reaction in a rat model using proton nuclear magnetic resonance (1H NMR) spectroscopy and rapid resolution liquid chromatography (RRLC). 61
23511749 2013
39
Exogenous application of hydrogen sulfide donor attenuates inflammatory reactions through the L-selectin-involved pathway in the cutaneous reverse passive Arthus reaction. 61
23381473 2013
40
Isoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model. 61
23096126 2013
41
Basophils and mast cells play critical roles for leukocyte recruitment in IgE-mediated cutaneous reverse passive Arthus reaction. 61
22784785 2012
42
Hydrodynamic delivery of plasmid DNA encoding human FcγR-Ig dimers blocks immune-complex mediated inflammation in mice. 61
22113315 2012
43
α-1-Antitrypsin and IFN-γ reduce the severity of IC-mediated vasculitis by regulation of leukocyte recruitment in vivo. 61
22572816 2012
44
Anti-inflammatory and vasoprotective activity of a retroviral-derived peptide, homologous to human endogenous retroviruses: endothelial cell effects. 61
23285152 2012
45
Hypersensitivity to rabbit antithymocyte globulin in an islet transplant recipient: a case report. 61
22099783 2011
46
Deletion of Syk in neutrophils prevents immune complex arthritis. 61
21918195 2011
47
Immunomodulatory and therapeutic potential of a mycelial lectin from Aspergillus nidulans. 61
21590306 2011
48
Neutrophil development and function critically depend on Bruton tyrosine kinase in a mouse model of X-linked agammaglobulinemia. 61
21063022 2011
49
Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits type I-IV allergic inflammation and pro-inflammatory enzymes. 61
20607501 2010
50
Generation of a high-affinity Fcgamma receptor by Ig-domain swapping between human CD64A and CD16A. 61
20150179 2010

Variations for Arthus Reaction

Expression for Arthus Reaction

Search GEO for disease gene expression data for Arthus Reaction.

Pathways for Arthus Reaction

Pathways related to Arthus Reaction according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.39 TNF SELL NOS2 MIF ICAM1 HMOX1
2
Show member pathways
12.47 TNF ICAM1 FCGR2B FCGR2A FCGR1A
3 12.38 TNF HMOX1 CD46 ALOX5
4
Show member pathways
12.16 TNF ICAM1 ALOX5 ALB
5
Show member pathways
12.01 TNF NOS2 FCGR2A FCGR1A CR1 ALOX5
6 11.89 SELL ICAM1 FCGR2B FCGR1A
7 11.89 TNF NOS2 FCGR2B FCGR2A FCGR1A CR1
8 11.88 TNF NOS2 MIF ICAM1 FCGR2A
9 11.82 TNF SELL FCGR2A
10 11.82 TNF NOS2 ICAM1 HMOX1 ALOX5
11 11.73 TNF FCGR1A CR1
12 11.71 FCGR2B FCGR2A FCGR1A
13 11.7 ICAM1 FCGR2B FCGR2A FCGR1A C5AR1
14 11.64 FCGR2A FCGR1A CR1
15
Show member pathways
11.53 TNF NOS2 MIF ICAM1
16 11.39 TNF ICAM1 CR1
17 11.33 TNF ICAM1 ELANE
18 10.92 TNF NOS2 ICAM1 FCGR2B FCGR2A CR1
19 10.87 TNF HMOX1
20 10.78 TNF ICAM1

GO Terms for Arthus Reaction

Cellular components related to Arthus Reaction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.03 TNF SELL NOS2 MIF ICAM1 HRH1
2 cell surface GO:0009986 9.5 TNF MIF ICAM1 ELANE CR1 CD46
3 secretory granule membrane GO:0030667 9.46 SELL FCGR2A CR1 C5AR1
4 integral component of plasma membrane GO:0005887 9.32 TNF SELL ICAM1 HRH1 FCGR2B FCGR2A

Biological processes related to Arthus Reaction according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.89 MIF FCGR2B FCGR2A FCGR1A
2 negative regulation of gene expression GO:0010629 9.88 TNF NOS2 MIF CD46
3 regulation of complement activation GO:0030449 9.79 CR1 CD46 C5AR1
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.76 TNF MIF ICAM1 C5AR1
5 viral entry into host cell GO:0046718 9.72 ICAM1 CR1 CD46
6 cytokine-mediated signaling pathway GO:0019221 9.72 TNF NOS2 ICAM1 HMOX1 ALOX5
7 response to lipopolysaccharide GO:0032496 9.71 NOS2 ICAM1 ELANE C5AR1
8 regulation of insulin secretion GO:0050796 9.67 TNF NOS2 ALOX5
9 regulation of immune response GO:0050776 9.65 SELL ICAM1 FCGR2B FCGR2A FCGR1A
10 astrocyte activation GO:0048143 9.61 TNF C5AR1
11 positive regulation of smooth muscle cell proliferation GO:0048661 9.61 TNF HMOX1 ELANE
12 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.6 TNF ICAM1
13 leukocyte migration involved in inflammatory response GO:0002523 9.58 ELANE ALOX5
14 positive regulation of regulatory T cell differentiation GO:0045591 9.57 CR1 CD46
15 complement receptor mediated signaling pathway GO:0002430 9.56 CR1 C5AR1
16 leukocyte migration GO:0050900 9.55 TNF SELL MIF ICAM1 ELANE
17 regulation of cytokine production involved in inflammatory response GO:1900015 9.54 NOS2 ALOX5
18 negative regulation of vascular wound healing GO:0061044 9.52 TNF ALOX5
19 negative regulation of immunoglobulin production GO:0002638 9.51 FCGR2B CR1
20 neutrophil degranulation GO:0043312 9.5 SELL MIF FCGR2A ELANE CR1 C5AR1
21 acute inflammatory response to antigenic stimulus GO:0002438 9.48 ICAM1 ELANE
22 positive regulation of leukocyte adhesion to arterial endothelial cell GO:1904999 9.37 TNF ALOX5
23 inflammatory response GO:0006954 9.17 TNF NOS2 MIF HRH1 FCGR2B C5AR1

Molecular functions related to Arthus Reaction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.46 ICAM1 FCGR2B FCGR2A FCGR1A
2 protease binding GO:0002020 9.43 TNF SELL ELANE
3 virus receptor activity GO:0001618 9.13 ICAM1 CR1 CD46
4 IgG binding GO:0019864 8.8 FCGR2B FCGR2A FCGR1A

Sources for Arthus Reaction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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