Articulation Disorder disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ART014 MIFTS: 34	Articulation Disorder Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Articulation Disorder

MalaCards integrated aliases for Articulation Disorder:

Name: Articulation Disorder ¹² ¹⁵

Articulation Disorders ⁴⁴ ⁷⁰

Phonological Disorder ¹² ⁷⁰

Articulation Impairment ¹²

Speech Sound Disorders ⁷⁰

Classifications:

MalaCards categories:
Anatomical: Mental diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4186

MeSH ⁴⁴ D001184

SNOMED-CT ⁶⁷ 8187005

UMLS ⁷⁰ C0003910 C4019167 C4048283

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Summaries for Articulation Disorder

Disease Ontology : ¹² A speech disorder that involves mispronouncing speech sounds by omitting, distorting, substituting, or adding sounds which can make speech difficult to understand.

MalaCards based summary : Articulation Disorder, also known as articulation disorders, is related to childhood apraxia of speech and speech and communication disorders. An important gene associated with Articulation Disorder is NAGPA (N-Acetylglucosamine-1-Phosphodiester Alpha-N-Acetylglucosaminidase), and among its related pathways/superpathways are Lysosome and MECP2 and Associated Rett Syndrome. The drugs tannic acid and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include tongue, brain and temporal lobe, and related phenotype is normal.

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Related Diseases for Articulation Disorder

Diseases related to Articulation Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)

#	Related Disease	Score	Top Affiliating Genes
1	childhood apraxia of speech	32.2	FOXP2 CNTNAP2
2	speech and communication disorders	29.6	NAGPA GNPTG FOXP2 CNTNAP2 CEBPD ATP2C2
3	movement disease	29.6	GAD1 DRD2 CNTNAP2
4	dyslexia	29.2	NAGPA GNPTG GNPTAB FOXP2 DRD2 CNTNAP2
5	stuttering	29.2	SST PVALB PDE5A NAGPA MT-CYB LINC01554
6	speech disorder	27.9	SST PVALB NAGPA MT-CYB LINC01554 GNPTG
7	abnormal hair, joint laxity, and developmental delay	11.0
8	tarsal tunnel syndrome	10.4	GNPTG GNPTAB
9	tibial neuropathy	10.4	GNPTG GNPTAB
10	mucolipidoses	10.4	GNPTG GNPTAB
11	pediculus humanus capitis infestation	10.3	MT-CYB LINC01554
12	hurler syndrome	10.3	NAGPA GNPTG GNPTAB
13	mucolipidosis iii alpha/beta	10.3	NAGPA GNPTG GNPTAB
14	mucolipidosis	10.3	NAGPA GNPTG GNPTAB
15	mucolipidosis ii alpha/beta	10.3	NAGPA GNPTG GNPTAB
16	mucopolysaccharidosis-plus syndrome	10.3	NAGPA GNPTG GNPTAB
17	breast fibrosarcoma	10.3	PVALB CALB1
18	osteogenesis imperfecta, type vii	10.3	GNPTAB GAD1
19	mucolipidosis iii gamma	10.2	GNPTG GNPTAB
20	paroxysmal dystonia	10.2	SST PVALB CALB2
21	pitt-hopkins-like syndrome 1	10.2	CNTNAP2 AP4E1
22	echolalia	10.2	FOXP2 CNTNAP2 CEBPD
23	tic disorder	10.2	PVALB DRD2 CNTNAP2
24	expressive language disorder	10.2	FOXP2 CEBPD ATP2C2
25	learning disability	10.2	FOXP2 CNTNAP2 CEBPD
26	developmental coordination disorder	10.2	CEBPD ATP2C2
27	diamond-blackfan anemia 5	10.1	SST PVALB
28	choreatic disease	10.1	PVALB DRD2 CNTNAP2
29	temporal lobe epilepsy	10.1	PVALB GAD1 CALB1
30	dysphagia	10.1
31	gilles de la tourette syndrome	10.1	PVALB DRD2 CNTNAP2
32	cleft lip	10.1
33	cleft lip/palate	10.1
34	status epilepticus	10.1	SST PVALB CALB2 CALB1
35	optic nerve disease	10.1	PDE5A MT-CYB DCAF8
36	kagami-ogata syndrome	10.1	PVALB GAD1 DRD2 CALB1
37	early infantile epileptic encephalopathy	10.0	SST PVALB GAD1 CNTNAP2
38	cleft palate, isolated	10.0
39	apraxia	10.0
40	cerebral palsy	10.0
41	specific developmental disorder	10.0	PVALB FOXP2 DRD2 DCAF8 CNTNAP2
42	benign epilepsy with centrotemporal spikes	10.0	FOXP2 CNTNAP2 CEBPD ATP2C2
43	pervasive developmental disorder	10.0	PVALB GAD1 FOXP2 DRD2 CNTNAP2
44	reading disorder	9.9	NAGPA FOXP2 CNTNAP2 CEBPD ATP2C2
45	rett syndrome	9.9	SST GAD1 DRD2 CEBPD
46	dystonia	9.9	SST PVALB MT-CYB DRD2 CALB2
47	major depressive disorder	9.9	SST PVALB GAD1 DRD2
48	epilepsy, familial temporal lobe, 8	9.9	GAD1 DRD2
49	brain injury	9.9
50	hypotonia	9.9

Graphical network of the top 20 diseases related to Articulation Disorder:

Sources

Symptoms & Phenotypes for Articulation Disorder

MGI Mouse Phenotypes related to Articulation Disorder:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	normal	MP:0002873	9.23	CALB1 CALB2 DRD2 GAD1 GNPTAB PDE5A

Sources

Drugs & Therapeutics for Articulation Disorder

Drugs for Articulation Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

tannic acid

Approved

1401-55-4

Benzocaine

Approved, Investigational

1994-09-7, 94-09-7

2337

Synonyms:

(p-(Ethoxycarbonyl)phenylamine

06952_FLUKA

112909_ALDRICH

112909_SIAL

1333-08-0

23239-88-5

23239-88-5 (hydrochloride)

4 Aminobenzoic Acid Ethyl Ester

4-(Ethoxycarbonyl)aniline

4-(Ethoxycarbonyl)phenylamine

4-14-00-01129 (Beilstein Handbook Reference)

4-Aminobenzoate

4-Aminobenzoate ethyl ester

4-Aminobenzoic acid

4-aminobenzoic acid ethyl ester

4-amino-benzoic acid ethyl ester

4-Aminobenzoic acid ethyl ester

4-Aminobenzoic acid, ethyl ester

4-Carbethoxyaniline

71123-91-6

94-09-7

94-09-7 (Parent)

A0271

AB00051923

AC1L1DGC

AC1Q341A

AC1Q64JE

Acetate, benzocaine

Acetate, Benzocaine

AE-562/40377256

Aethoform

Aethylium paraminobenzoicum

AI3-02081

AKOS000119763

Amben ethyl ester

Americaine

Anaesthan-syngala

Anaesthesin

Anaesthesinum

Anaesthin

Anestezin

Anestezin [Russian]

Anesthesin

Anesthesine

Anesthone

AR-1H9065

Baby anbesol

Baby Anbesol

BB_SC-0019

Bensokain

Benzoak

Benzocaina

Benzocaina [INN-Spanish]

benzocaine

Benzocaine

Benzocaine (USP/INN)

Benzocaine [INN:BAN]

Benzocaine acetate

Benzocaine Acetate

Benzocaine formate

Benzocaine Formate

Benzocaine hydrobromide

Benzocaine Hydrobromide

Benzocaine hydrochloride

Benzocaine Hydrochloride

Benzocaine methanesulfonate

Benzocaine Methanesulfonate

Benzocainum

Benzocainum [INN-Latin]

Benzoic acid, 4-amino-, ethyl ester

Benzoic acid, 4-amino-, ethyl ester, hydrochloride

Benzoic acid, amino-, ethyl ester

Benzoic acid, p-amino-, ethyl ester

BPBio1_001017

BRD-K75466013-001-05-2

BRN 0638434

BSPBio_000923

BSPBio_001908

C07527

CAS-94-09-7

Caswell No. 430A

CHEBI:116735

CHEMBL278172

Chloraseptic

CID2337

D001566

D00552

DB01086

Dermoplast

Diet ayds

DivK1c_000932

E1501_SIGMA

EINECS 202-303-5

EPA Pesticide Chemical Code 097001

Ethoform

Ethoforme

Ethyl 4-aminobenzoate

Ethyl 4-aminobenzoate hydrochloride

Ethyl 4-aminobenzoic acid

Ethyl aminobenzoate

Ethyl aminobenzoate (JP15)

Ethyl aminobenzoate (VAN)

Ethyl aminobenzoic acid

Ethyl PABA

Ethyl p-aminobenzenecarboxylate

Ethyl p-aminobenzoate

Ethyl p-aminobenzoic acid

Ethyl p-aminophenylcarboxylate

Ethyl p-aminophenylcarboxylic acid

ethylaminobenzoate-4

Ethylester kyseliny p-aminobenzoove

Ethylester kyseliny p-aminobenzoove [Czech]

Ethylis aminobenzoas

ETHYL-P-AMINOBENZOATE

Formate, benzocaine

Formate, Benzocaine

h-4-abz-oet

HMS1570O05

HMS1920G09

HMS2091M11

HMS502O14

HSDB 7225

Hurricaine

Hydrobromide, benzocaine

Hydrobromide, Benzocaine

Hydrochloride, benzocaine

Hydrochloride, Benzocaine

I05-0204

Identhesin

IDI1_000932

KBio1_000932

KBio2_000474

KBio2_003042

KBio2_005610

KBio3_001408

KBioGR_000658

KBioSS_000474

Keloform

LS-35847

Methanesulfonate, benzocaine

Methanesulfonate, Benzocaine

MLS001331704

MLS002153970

MolPort-000-871-526

NCGC00016352-01

NCGC00094598-01

NCGC00094598-02

nchembio.182-comp4

NINDS_000932

Norcain

Norcaine

Norcainum

NSC 122792

NSC 41531

NSC41531

NSC4688

Oprea1_750694

Oprea1_827402

Orabase-b

Ora-jel

Orthesin

Otocain

Outgro

p-(Ethoxycarbonyl)aniline

p-Aminobenzoate

p-Aminobenzoic acid

p-Aminobenzoic acid ethyl ester

p-Aminobenzoic acid, ethyl ester

p-Aminobenzoic ethyl ester

Parathesin

Parathesin (TN)

Parathesine

p-Carbethoxyaniline

p-Ethoxycarboxylic aniline

Prestwick_991

Prestwick0_000712

Prestwick1_000712

Prestwick2_000712

Prestwick3_000712

Slim mint gum

SMR000059025

Solarcaine

Solu H

SPBio_000134

SPBio_002844

Spectrum_000074

SPECTRUM1500139

Spectrum2_000117

Spectrum3_000314

Spectrum4_000249

Spectrum5_000860

STK043620

Topcaine

UNII-U3RSY48JW5

WLN: ZR DVO2

ZINC12358719

Silver sulfadiazine

Approved, Vet_approved

22199-08-2

441244

Synonyms:

(4-Amino-N-pyrimidin-2-ylbenzenesulphonamidato-NN,O1)silver

22199-08-2

481181_ALDRICH

4-Amino-N-(2-pyrimidinyl)benzenesulfonamide silver salt

4-amino-N-pyrimidin-2-ylbenzenesulfonamide

Abbott Brand of Silver Sulfadiazine

AC-19319

AC1L1KQS

AC1L9ATF

AC1L9Q6O

AC1NUR63

AC1O8LAG

AC-3535

AKOS005111099

AKOS005111434

Aldo Brand of Silver Sulfadiazine

ARONIS23842

Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-, monosilver(1+) salt

Benzenesulfonamide,4-amino-N-2-pyrimidinyl-, silver complex

Brandiazin

C10H9N4O2S.Ag

CHEBI:9142

CHEMBL1200766

CID11947738

CID31011

CID441244

CID452254

CID5459124

D00433

D012837

DB05245

Dermazin

Dermazine

EINECS 244-834-5

Flamazine

Flammazine

Geben

I06-0145

I06-145

LS-147839

Major Brand of Silver Sulfadiazine

medphano Brand of Silver Sulfadiazine

MLS000069662

MolPort-003-934-423

MolPort-003-986-619

MolPort-006-395-987

Monarch Brand of Silver Sulfadiazine

N(sup 1)-2-Pyrimidinylsulfanilamide monosilver(1+) salt

N1-2-Pyrimidinylsulfanilamide monosilver(1+) salt

NSC 625324

NSC625324

Par Brand 1 of Silver Sulfadiazine

Par Brand 2 of Silver Sulfadiazine

Par Brand 3 of Silver Sulfadiazine

Pharmascience Brand of Silver Sulfadiazine

Rhone Poulenc Rorer Brand of Silver Sulfadiazine

Rhone-Poulenc Rorer Brand of Silver Sulfadiazine

S0595

Sherwood Brand of Silver Sulfadiazine

Sicazine

Silbertone

Sildaflo

Silvadene

Silvadene (TN)

Silvederma

silver

silver (4-aminophenyl)sulfonyl-pyrimidin-2-ylazanide

silver 4-amino-N-pyrimidin-2-ylbenzenesulfonamide

silver sulfadiazinate

Silver sulfadiazinate

silver sulfadiazine

Silver sulfadiazine

Silver Sulfafdiazine

Silver sulphadiazine

silver(1+) [(4-aminophenyl)sulfonyl](pyrimidin-2-yl)azanide

Silver(I) sulfadiazine

Smith & Nephew Brand of Silver Sulfadiazine

SMR000059233

Solvay Brand of Silver Sulfadiazine

SSD

SSD (1% Silver Sulfadiazine Cream USP)

SSD AF

STL069502

Sulfadiazin silber

Sulfadiazin, silbersalz

Sulfadiazine silver

SULFADIAZINE SILVER

Sulfadiazine silver (JP15)

Sulfadiazine silver salt

Sulfadiazine silverSilvadene

Sulfadiazine, silver

Sulfadiazine, silver (USP)

Sulfadiazine, Silver [USAN]

Sulfafdiazine, Silver

Sulfanilamide, N(sup 1)-2-pyrimidinyl-, monosilver(1+) salt

Sulfanilamide,N1-2-pyrimidinyl-, monosilver(1+) salt

Sulfargen

Thermazene

TL8001845

UNII-W46JY43EJR

Zenith Brand of Silver Sulfadiazine

Interventional clinical trials:

(show all 21)

#	Name	Status	NCT ID	Phase
1	The Contribution of a Speech Perception Intervention to the Prevention of Phonological Awareness Deficits in Children With Speech Sound Disorders	Unknown status	NCT00818428	Phase 2, Phase 3
2	Correcting Residual Errors With Spectral, Ultrasound, and Traditional Speech Therapy: A Randomized Controlled Trial	Recruiting	NCT03737318	Phase 2
3	Biofeedback and Speech Disorders	Completed	NCT01905449	Phase 1
4	staRt: Enhancing Speech Treatment With Smartphone-delivered Biofeedback	Completed	NCT04474691	Phase 1
5	Correcting Residual Errors With Spectral, Ultrasound, and Traditional Speech Therapy: Delineation of Sensorimotor Subtypes	Recruiting	NCT03736213	Phase 1
6	Comparing Traditional and Biofeedback Treatment for Residual Speech Errors Via Telepractice	Recruiting	NCT04625062	Phase 1
7	Early Intervention for Speech Sound Disorder in Very Preterm Children	Unknown status	NCT01352481
8	New Therapeutical Perspectives in Cases of Phonological Disorders	Completed	NCT02935062
9	Age-related Correlates of Treatment Efficacy and Efficiency for Late-acquired Sounds	Completed	NCT03663972
10	Evaluating the Efficacy of Opti-Speech, a 3D Visual Feedback System, for Speech Treatment	Completed	NCT02705326
11	Characteristics of Idiopathic Familial Speech Disorders	Completed	NCT00001551
12	Brain Activation During Developmental Speech Production and Speech Perception	Completed	NCT00004991
13	Intervention Software for Children With Speech Sound Disorders	Completed	NCT02490826
14	Formulatin and Application of a Remediation Software Porgram for Correction of Articulatory Errors in Patients With Velopfaryngeal Dysfunction	Completed	NCT04392817
15	Evaluation of the Internal Rotation Deficit of the Glenohumeral Joint in Advanced-level Handball Players Occurring Over One Training Season	Completed	NCT02011243
16	Influence of a Intervention Break on a Treated Phonological Process in Spontaneous Speech Situations in Children Aged 5 to 6 Years With Phonologically Delayed Development	Recruiting	NCT03972891
17	Efficacy of an Intervention for the Children With Severe Speech Sounds Disorders	Recruiting	NCT03700151
18	A Developmental Framework For Linking Phonological And Morpho-syntactic Sequential Pattern Rules In Developmental Language Disorder: Production	Recruiting	NCT04558541	Early Phase 1
19	Identification of Electrophysiological Indices of Speech Sound Perception and Change in Children With Speech Sound Disorders	Active, not recruiting	NCT03623100
20	The Impact of Beatboxing on the Management of Individuals With Residual Speech Errors	Not yet recruiting	NCT03972449
21	How to Promote Children's Language Development Using Family-based Shared Book Reading: Study B; Examining the Effect of Training Shared Reading Practice, With Form-emphasising Books, on Children's Language and Phonological Awareness	Withdrawn	NCT03006744

Search NIH Clinical Center for Articulation Disorder

Cochrane evidence based reviews: articulation disorders

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Genetic Tests for Articulation Disorder

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Anatomical Context for Articulation Disorder

MalaCards organs/tissues related to Articulation Disorder:

⁴⁰

Tongue, Brain, Temporal Lobe, Cortex, Bone, Breast, Prostate

Sources

Publications for Articulation Disorder

Articles related to Articulation Disorder:

(show top 50) (show all 212)

#	Title	Authors	PMID	Year
1	Contralateral suppression of transient evoked otoacoustic emissions in children with phonological disorder. ⁶¹	Yilmaz S...Bulut E	33283490	2021
2	Differential Diagnosis of Childhood Apraxia of Speech Compared to Other Speech Sound Disorders: A Systematic Review. ⁶¹	Murray E...Ballard KJ	33151751	2021
3	"It Is Not the Robot Who Learns, It Is Me." Treating Severe Dysgraphia Using Child-Robot Interaction. ⁶¹	Gargot T...Anzalone SM	33716812	2021
4	Application of childhood apraxia of speech clinical markers to French-speaking children: A preliminary study. ⁶¹	Meloni G...MacLeod AAN	33666129	2020
5	Mismatch Negativity in children with Phonological Disorders. ⁶¹	El Hatal de Souza A...Vieira Biaggio EP	33080473	2020
6	Association between phonation and the vowel quadrilateral in patients with stroke: A retrospective observational study. ⁶¹	Park EJ...Yoo SD	32991418	2020
7	An accessory tongue in a child: A clinical case. ⁶¹	Ohara K...Harabuchi Y	32819761	2020
8	Predicting speech-sound disorder outcomes in school-age children with hearing loss: The VicCHILD experience. ⁶¹	St John M...Morgan AT	32374456	2020
9	Speech-language therapy students' auditory-perceptual judgements of simulated concurrent hypernasality and articulation disorders. ⁶¹	Lee A...Bressmann T	31429313	2020
10	Evidence for [Coronal] Underspecification in Typical and Atypical Phonological Development. ⁶¹	Cummings AE...Wu YC	33414710	2020
11	Indicators of speech fluency in stuttering and in phonological disorder. ⁶¹	Alencar PBA...Berti LC	32267336	2020
12	The Neurocognition of Developmental Disorders of Language. ⁶¹	Ullman MT...Janacsek K	31337273	2020
13	The application of the maximal opposition therapy approach to an Arabic-speaking child. ⁶¹	Alsaad M...Purcell A	31279082	2019
14	Correlations Between Values of Articulation Tests and Language Tests for Children With Articulation Disorder in Korea. ⁶¹	Choi KM...Jung MJ	31499602	2019
15	Acute onset bilateral hearing loss in dorsomedial pontine hemorrhage: A Case report. ⁶¹	Hoshino M...Hasegawa Y	31441869	2019
16	Analysis of the components of Frequency-Following Response in phonological disorders. ⁶¹	Ferreira L...Biaggio EPV	30959337	2019
17	Is excessive visual crowding causally linked to developmental dyslexia? ⁶¹	Bertoni S...Facoetti A	31077708	2019
18	Validation of Dodd's Model for Differential Diagnosis of childhood speech sound disorders: a longitudinal community cohort study. ⁶¹	Ttofari Eecen K...Reilly S	30151900	2019
19	Treatment Targets for Co-Occurring Speech-Language Impairment: A Case Study. ⁶¹	Combiths PN...Pruitt-Lord SL	31214657	2019
20	Speech and language in children with Klinefelter syndrome. ⁶¹	St John M...Morgan AT	30822601	2019
21	Lambdacism, Rhotacism and Sigmatism in Preschool Children: Frequency and Distribution. ⁶¹	Georgievska-Jancheska T	30833997	2019
22	Quantifying phonological knowledge in children with phonological disorder. ⁶¹	Combiths PN...Sanchez E	31379215	2019
23	Pseudowords to the Phonological Therapy: a new therapeutic approach. ⁶¹	Bonini JB...Keske-Soares M	30517266	2018
24	Treatment of Phonological Disorder: A Feasibility Study With Focus on Outcome Measures. ⁶¹	Smit AB...Hilgers M	29466550	2018
25	The phonological memory profile of preschool children who make atypical speech sound errors. ⁶¹	Waring R...Dodd B	28590148	2018
26	Cerebral Hemodynamics in Speech-Related Cortical Areas: Articulation Learning Involves the Inferior Frontal Gyrus, Ventral Sensory-Motor Cortex, and Parietal-Temporal Sylvian Area. ⁶¹	Nakamichi N...Nishijo H	30443239	2018
27	Performance of children with speech sound disorders in the dynamic evaluation of motor speech skills. ⁶¹	Keske-Soares M...Pagliarin KC	29791618	2018
28	Paediatric Automatic Phonological Analysis Tools (APAT). ⁶¹	Saraiva D...Jesus LMT	27724177	2017
29	Pure apraxia of speech due to infarct in premotor cortex. ⁶¹	Patira R...Altschuler EL	28844393	2017
30	Lingual alveolar soft part sarcoma responsive to pazopanib: A case report. ⁶¹	Yoshihiro T...Baba E	29095301	2017
31	Prevalence of speech and language disorders in children in the western region of São Paulo. ⁶¹	Longo IA...Molini-Avejonas DR	29160334	2017
32	Speech profile of patients undergoing primary palatoplasty. ⁶¹	Menegueti KI...Andrade CRF	29091112	2017
33	Speech and Linguistic Features of Children With Articulation Disorder. ⁶¹	Kim J...Kim HI	29201823	2017
34	Increased activation of the hippocampus during a Chinese character subvocalization task in adults with cleft lip and palate palatoplasty and speech therapy. ⁶¹	Zhang W...Chen R	28658048	2017
35	Phonologic and Acoustic Analysis of Speech Following Glossectomy and the Effect of Rehabilitation on Speech Outcomes. ⁶¹	Takatsu J...Yamamoto M	28039737	2017
36	Transient hypoglossal nerve palsy after transoral intubation for general anesthesia. ⁶¹	Choi YJ...Shin YD	28811811	2017
37	Longitudinal follow-up to evaluate speech disorders in early-treated patients with infantile-onset Pompe disease. ⁶¹	Zeng YT...Chien YH	28039015	2017
38	Potocki-Shaffer syndrome in a child without intellectual disability-The role of PHF21A in cognitive function. ⁶¹	McCool C...Potocki L	28127865	2017
39	[Phonological characteristics and rehabilitation training of abnormal velar in children with functional articulation disorders]. ⁶¹	Lina X...Mingfang H	28318160	2016
40	[Property analysis of the finals mispronunciation in Chinese-speaking children with functional articulation disorder]. ⁶¹	Du ZH...Chen ZM	27784477	2016
41	[Temporomandibular joint septic arthritis with secondary condylar resorption]. ⁶¹	Constant M...Ferri J	27522243	2016
42	Out-of-synchrony speech entrainment in developmental dyslexia. ⁶¹	Molinaro N...Carreiras M	27061643	2016
43	Structure of a New Palatal Plate and the Artificial Tongue for Articulation Disorder in a Patient with Subtotal Glossectomy. ⁶¹	Kozaki KI...Okayama Dream Speech Project	27339210	2016
44	Tongue displacement and durational characteristics of normal and disordered Brazilian Portuguese liquids. ⁶¹	Berti L...Bressmann T	26853548	2016
45	Successful and rapid response of speech bulb reduction program combined with speech therapy in velopharyngeal dysfunction: a case report. ⁶¹	Shin YJ...Ko SO	26258115	2015
46	A Randomized Trial of 12-Week Interventions for the Treatment of Developmental Phonological Disorder in Francophone Children. ⁶¹	Rvachew S...Brosseau-Lapre F	26381229	2015
47	Changes of some functional speech disorders after surgical correction of skeletal anterior open bite. ⁶¹	Knez Ambrozic M...Ihan Hren N	26164798	2015
48	Word production inconsistency of Singaporean-English-speaking adolescents with Down Syndrome. ⁶¹	Wong B...Butcher A	26149647	2015
49	Speech rate and fluency in children with phonological disorder. ⁶¹	Novaes PM...Lopes-Herrera SA	26398256	2015
50	Phonemic discrimination and the relationship with other linguistic levels in children with typical phonological development and phonological disorder. ⁶¹	Freitas CR...Vidor DC	26222939	2015

Sources

Genes for Articulation Disorder

Genes related to Articulation Disorder (0 elite genes):

(show all 27)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NAGPA	N-Acetylglucosamine-1-Phosphodiester Alpha-N-Acetylglucosaminidase	Protein Coding	8.54	DISEASES inferred ¹⁵
2	GNPTG	N-Acetylglucosamine-1-Phosphate Transferase Subunit Gamma	Protein Coding	8.07	DISEASES inferred ¹⁵
3	GNPTAB	N-Acetylglucosamine-1-Phosphate Transferase Subunits Alpha And Beta	Protein Coding	7.56	DISEASES inferred ¹⁵
4	FOXP2	Forkhead Box P2	Protein Coding	7.24	DISEASES inferred ¹⁵
5	HEPHL1	Hephaestin Like 1	Protein Coding	7.21	GeneCards inferred via : Disorders (show sections)
6	DCAF8	DDB1 And CUL4 Associated Factor 8	Protein Coding	7.05	DISEASES inferred ¹⁵ ¹⁵
7	PVALB	Parvalbumin	Protein Coding	7.03	DISEASES inferred ¹⁵
8	LINC01554	Long Intergenic Non-Protein Coding RNA 1554	RNA Gene	6.75	DISEASES inferred ¹⁵
9	AP4E1	Adaptor Related Protein Complex 4 Subunit Epsilon 1	Protein Coding	6.73	DISEASES inferred ¹⁵
10	ARHGDIA	Rho GDP Dissociation Inhibitor Alpha	Protein Coding	6.39	DISEASES inferred ¹⁵
11	MT-CYB	Mitochondrially Encoded Cytochrome B	Protein Coding	6.34	DISEASES inferred ¹⁵
12	GAD1	Glutamate Decarboxylase 1	Protein Coding	6.32	DISEASES inferred ¹⁵
13	SST	Somatostatin	Protein Coding	6.29	DISEASES inferred ¹⁵
14	CALB1	Calbindin 1	Protein Coding	6.27	DISEASES inferred ¹⁵
15	CNTNAP2	Contactin Associated Protein 2	Protein Coding	6.26	DISEASES inferred ¹⁵
16	CALB2	Calbindin 2	Protein Coding	6.16	DISEASES inferred ¹⁵
17	CEBPD	CCAAT Enhancer Binding Protein Delta	Protein Coding	6.11	DISEASES inferred ¹⁵
18	PDE5A	Phosphodiesterase 5A	Protein Coding	6.09	DISEASES inferred ¹⁵
19	DRD2	Dopamine Receptor D2	Protein Coding	5.92	DISEASES inferred ¹⁵
20	ATP2C2	ATPase Secretory Pathway Ca2+ Transporting 2	Protein Coding	5.77	DISEASES inferred ¹⁵
21	GTPBP1	GTP Binding Protein 1	Protein Coding	5.76	DISEASES inferred ¹⁵
22	CMIP	C-Maf Inducing Protein	Protein Coding	5.75	DISEASES inferred ¹⁵
23	CCK	Cholecystokinin	Protein Coding	5.74	DISEASES inferred ¹⁵
24	NPY	Neuropeptide Y	Protein Coding	5.67	DISEASES inferred ¹⁵
25	SLC6A3	Solute Carrier Family 6 Member 3	Protein Coding	5.67	DISEASES inferred ¹⁵
26	GYPE	Glycophorin E (MNS Blood Group)	Protein Coding	5.66	DISEASES inferred ¹⁵
27	GP2	Glycoprotein 2	Protein Coding	5.63	DISEASES inferred ¹⁵

Sources

Variations for Articulation Disorder

Sources

Expression for Articulation Disorder

Search GEO for disease gene expression data for Articulation Disorder.

Sources

Pathways for Articulation Disorder

Pathways related to Articulation Disorder according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Lysosome ³⁶	11.03	NAGPA GNPTG GNPTAB AP4E1
2	MECP2 and Associated Rett Syndrome ¹	10.92	SST GAD1 CEBPD

Sources

GO Terms for Articulation Disorder

Cellular components related to Articulation Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	synapse	GO:0045202	9.73	SST GAD1 DRD2 CALB2 CALB1 ARHGDIA
2	axon	GO:0030424	9.55	PVALB GAD1 DRD2 CNTNAP2 CALB1
3	stereocilium	GO:0032420	9.13	PVALB CALB2 CALB1
4	cuticular plate	GO:0032437	8.8	PVALB CALB2 CALB1

Biological processes related to Articulation Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	response to drug	GO:0042493	9.62	SST MT-CYB GAD1 DRD2
2	carbohydrate phosphorylation	GO:0046835	9.37	GNPTG GNPTAB
3	regulation of presynaptic cytosolic calcium ion concentration	GO:0099509	9.26	CALB2 CALB1
4	regulation of long-term synaptic potentiation	GO:1900271	9.16	CALB2 CALB1
5	striatum development	GO:0021756	8.96	DRD2 CNTNAP2
6	secretion of lysosomal enzymes	GO:0033299	8.62	NAGPA GNPTAB

Molecular functions related to Articulation Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity	GO:0003976	8.96	GNPTG GNPTAB
2	calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration	GO:0099534	8.62	CALB2 CALB1

Sources

Sources for Articulation Disorder

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia