MCID: ART014
MIFTS: 31

Articulation Disorder

Categories: Mental diseases

Aliases & Classifications for Articulation Disorder

MalaCards integrated aliases for Articulation Disorder:

Name: Articulation Disorder 12 15
Articulation Disorders 44 73
Phonological Disorder 12 73
Articulation Impairment 12
Speech Sound Disorders 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4186
MeSH 44 D001184
SNOMED-CT 68 386701004 8187005

Summaries for Articulation Disorder

Disease Ontology : 12 A speech disorder that involves mispronouncing speech sounds by omitting, distorting, substituting, or adding sounds which can make speech difficult to understand.

MalaCards based summary : Articulation Disorder, also known as articulation disorders, is related to childhood apraxia of speech and stuttering. An important gene associated with Articulation Disorder is GNPTG (N-Acetylglucosamine-1-Phosphate Transferase Subunit Gamma), and among its related pathways/superpathways is Lysosome. Affiliated tissues include brain and tongue, and related phenotype is behavior/neurological.

Related Diseases for Articulation Disorder

Graphical network of the top 20 diseases related to Articulation Disorder:



Diseases related to Articulation Disorder

Symptoms & Phenotypes for Articulation Disorder

MGI Mouse Phenotypes related to Articulation Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.23 AP4E1 CD55 CNTNAP2 DRD2 GNPTAB PHF21A

Drugs & Therapeutics for Articulation Disorder

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Randomized Clinical Trial of Phonological Interventions Unknown status NCT00818428 Phase 2, Phase 3
2 Efficacy of Voice Treatment for Parkinson's Disease Unknown status NCT00123084 Phase 2
3 Improve Speech Using an In-the-ear Device in Parkinson's Disease Completed NCT00488657 Phase 1
4 Dysarthria in Parkinson's Disease: Lusophony vs. Francophony Comparison Unknown status NCT02753192 Not Applicable
5 Study of Brain Activity During Speech Production and Speech Perception Completed NCT00004991
6 Characteristics of Idiopathic Familial Speech Disorders Completed NCT00001551
7 Internal Rotation Deficit of the Glenohumeral Joint in Advanced-level Handball Players Completed NCT02011243
8 Study on the Phenotype of Language in Preterm Born Children at 5 Years of Age Completed NCT02988570 Not Applicable
9 Study of Speech Disorders , Voice and Swallowing in Primary Dystonia Oromandibular Completed NCT03380676
10 Study of Dysarthria, Swallowing Disorders and Respiratory in Parkinson's Disease Completed NCT02627664
11 Intensive Dysarthria Sessions in Adults and Children With Down Syndrome Completed NCT01684670 Not Applicable
12 New Therapeutical Perspectives in Cases of Phonological Disorders Recruiting NCT02935062 Not Applicable
13 Evaluating the Efficacy of Opti-Speech for Speech Treatment Recruiting NCT02705326 Not Applicable
14 Study of Dysarthria, and the Appearance of Non-dopaminergic Signs in Idiopathic PARKinson's Disease Recruiting NCT03517059
15 The Incidence of Aphasia, Dysarthria and Dysphagia Following Stroke Recruiting NCT03472625
16 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
17 Maturation of Auditory Processing in Children With Dyslexia Compared to Average-reading Children Active, not recruiting NCT02345876
18 A Comparison of Voice Amplifiers and Personal Communication Systems in Individuals With Parkinson's Disease Enrolling by invitation NCT02407067 Not Applicable
19 Acoustic and Perceptual Markers of Dysarthria in Amyotrophic Lateral Sclerosis (ALS) Not yet recruiting NCT03560661
20 Characterization of the Profile of Dysarthria in Huntington's Disease, Using the Clinical Evaluation Battery of Dysarthria Withdrawn NCT03142217 Not Applicable

Search NIH Clinical Center for Articulation Disorder

Cochrane evidence based reviews: articulation disorders

Genetic Tests for Articulation Disorder

Anatomical Context for Articulation Disorder

MalaCards organs/tissues related to Articulation Disorder:

41
Brain, Tongue

Publications for Articulation Disorder

Articles related to Articulation Disorder:

# Title Authors Year
1
Speech and Linguistic Features of Children With Articulation Disorder. ( 29201823 )
2017
2
Structure of a New Palatal Plate and the Artificial Tongue for Articulation Disorder in a Patient with Subtotal Glossectomy. ( 27339210 )
2016
3
A case of hemangiopericytoma of the soft palate with articulate disorder and dysphagia. ( 23703709 )
2013
4
Automatic detection of articulation disorders in children with cleft lip and palate. ( 19894838 )
2009
5
Linguistic development in cleft palate patients with and without compensatory articulation disorder. ( 10967376 )
2000
6
Atrophy of the tongue with persistent articulation disorder in myasthenia gravis: report of 10 patients. ( 7779022 )
1994
7
Perception of voiceless fricatives by children with a functional articulation disorder. ( 2709838 )
1989
8
The occurrence of developmental apraxia of speech in a mild articulation disorder: a case study. ( 2794108 )
1989
9
An articulation disorder in 17th-century Germany. ( 381336 )
1979

Variations for Articulation Disorder

Expression for Articulation Disorder

Search GEO for disease gene expression data for Articulation Disorder.

Pathways for Articulation Disorder

Pathways related to Articulation Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.11 AP4E1 GNPTAB GNPTG NAGPA SLC17A5

GO Terms for Articulation Disorder

Cellular components related to Articulation Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi apparatus GO:0005794 9.02 AP4E1 CNTNAP2 GNPTAB GNPTG NAGPA

Biological processes related to Articulation Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 forebrain development GO:0030900 9.46 DRD2 FOXP2
2 cerebral cortex development GO:0021987 9.43 CNTNAP2 FOXP2
3 lysosome organization GO:0007040 9.4 GNPTAB NAGPA
4 adult behavior GO:0030534 9.37 CNTNAP2 DRD2
5 carbohydrate phosphorylation GO:0046835 9.32 GNPTAB GNPTG
6 striatum development GO:0021756 9.26 CNTNAP2 DRD2
7 vocal learning GO:0042297 9.16 CNTNAP2 FOXP2
8 secretion of lysosomal enzymes GO:0033299 8.96 GNPTAB NAGPA
9 N-glycan processing to lysosome GO:0016256 8.62 GNPTAB GNPTG

Molecular functions related to Articulation Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity GO:0003976 8.62 GNPTAB GNPTG

Sources for Articulation Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....