MCID: ART014
MIFTS: 32

Articulation Disorder

Categories: Mental diseases

Aliases & Classifications for Articulation Disorder

MalaCards integrated aliases for Articulation Disorder:

Name: Articulation Disorder 12 15
Articulation Disorders 44 73
Phonological Disorder 12 73
Articulation Impairment 12
Speech Sound Disorders 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4186
MeSH 44 D001184
SNOMED-CT 68 8187005

Summaries for Articulation Disorder

Disease Ontology : 12 A speech disorder that involves mispronouncing speech sounds by omitting, distorting, substituting, or adding sounds which can make speech difficult to understand.

MalaCards based summary : Articulation Disorder, also known as articulation disorders, is related to childhood apraxia of speech and stuttering. An important gene associated with Articulation Disorder is GNPTG (N-Acetylglucosamine-1-Phosphate Transferase Subunit Gamma), and among its related pathways/superpathways is Lysosome. The drug Levodopa has been mentioned in the context of this disorder. Affiliated tissues include brain, tongue and testes, and related phenotype is behavior/neurological.

Related Diseases for Articulation Disorder

Graphical network of the top 20 diseases related to Articulation Disorder:



Diseases related to Articulation Disorder

Symptoms & Phenotypes for Articulation Disorder

MGI Mouse Phenotypes related to Articulation Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.17 AP4E1 CNTNAP2 DRD2 GNPTAB PHF21A SLC17A5

Drugs & Therapeutics for Articulation Disorder

Drugs for Articulation Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levodopa Approved 59-92-7 6047

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Randomized Clinical Trial of Phonological Interventions Unknown status NCT00818428 Phase 2, Phase 3
2 Lateral Cord Magnetic Stimulation For Refractory Spastic Cerebral Palsy Not yet recruiting NCT03676439 Phase 2, Phase 3
3 Improve Speech Using an In-the-ear Device in Parkinson's Disease Completed NCT00488657 Phase 1
4 New Therapeutical Perspectives in Cases of Phonological Disorders Unknown status NCT02935062 Not Applicable
5 Dysarthria in Parkinson's Disease: Lusophony vs. Francophony Comparison Unknown status NCT02753192 Not Applicable
6 Study of Brain Activity During Speech Production and Speech Perception Completed NCT00004991
7 Characteristics of Idiopathic Familial Speech Disorders Completed NCT00001551
8 Evaluating the Efficacy of Opti-Speech for Speech Treatment Completed NCT02705326 Not Applicable
9 Internal Rotation Deficit of the Glenohumeral Joint in Advanced-level Handball Players Completed NCT02011243
10 Study on the Phenotype of Language in Preterm Born Children at 5 Years of Age Completed NCT02988570 Not Applicable
11 Study of Speech Disorders , Voice and Swallowing in Primary Dystonia Oromandibular Completed NCT03380676
12 Study of Dysarthria, Swallowing Disorders and Respiratory in Parkinson's Disease Completed NCT02627664
13 Intensive Dysarthria Sessions in Adults and Children With Down Syndrome Completed NCT01684670 Not Applicable
14 Efficacy of Voice Treatment for Parkinson's Disease Completed NCT00123084 Not Applicable
15 Age-related Correlates of Treatment for Late-acquired Sounds Recruiting NCT03663972 Not Applicable
16 Laryngeal Adaptation for Speech and Swallowing Recruiting NCT03770377 Not Applicable
17 Rhythmic Entrainment in Bilingual Speakers With Dysarthria Recruiting NCT03645265 Not Applicable
18 A Systematic Investigation of Phonetic Complexity Effects on Articulatory Motor Performance in Progressive Dysarthria Recruiting NCT03613038 Not Applicable
19 Acoustic and Perceptual Markers of Dysarthria in Amyotrophic Lateral Sclerosis (ALS) Recruiting NCT03560661
20 Study of Dysarthria, and the Appearance of Non-dopaminergic Signs in Idiopathic PARKinson's Disease Recruiting NCT03517059
21 The Incidence of Aphasia, Dysarthria and Dysphagia Following Stroke Recruiting NCT03472625
22 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
23 Maturation of Auditory Processing in Children With Dyslexia Compared to Average-reading Children Active, not recruiting NCT02345876
24 Music Therapy Protocol to Support Bulbar and Respiratory Functions in ALS Active, not recruiting NCT03604822 Not Applicable
25 A Comparison of Voice Amplifiers and Personal Communication Systems in Individuals With Parkinson's Disease Enrolling by invitation NCT02407067 Not Applicable
26 MORbidity PRevalence Estimate In StrokE Not yet recruiting NCT03605381
27 Characterization of the Profile of Dysarthria in Huntington's Disease, Using the Clinical Evaluation Battery of Dysarthria Withdrawn NCT03142217 Not Applicable

Search NIH Clinical Center for Articulation Disorder

Cochrane evidence based reviews: articulation disorders

Genetic Tests for Articulation Disorder

Anatomical Context for Articulation Disorder

MalaCards organs/tissues related to Articulation Disorder:

41
Brain, Tongue, Testes

Publications for Articulation Disorder

Articles related to Articulation Disorder:

(show all 38)
# Title Authors Year
1
Three-dimensional ultrasound evaluation of tongue posture and its impact on articulation disorders in preschool children with anterior open bite. ( 30210041 )
2018
2
Speech and Linguistic Features of Children With Articulation Disorder. ( 29201823 )
2017
3
Audiovisual materials are effective for enhancing the correction of articulation disorders in children with cleft palate. ( 28109492 )
2017
4
Structure of a New Palatal Plate and the Artificial Tongue for Articulation Disorder in a Patient with Subtotal Glossectomy. ( 27339210 )
2016
5
Speech processing in children with functional articulation disorders. ( 25421354 )
2015
6
ARTICULATION DISORDERS IN SERBIAN LANGUAGE IN CHILDREN WITH SPEECH PATHOLOGY. ( 26234024 )
2015
7
Articulation disorders and duration, severity and L-dopa dosage in idiopathic Parkinson's disease. ( 26377981 )
2015
8
Sensory integration dysfunction affects efficacy of speech therapy on children with functional articulation disorders. ( 23355780 )
2013
9
Automatic detection of articulation disorders in children with cleft lip and palate. ( 19894838 )
2009
10
Electropalatography for articulation disorders associated with cleft palate. ( 19588407 )
2009
11
Speech sound classification and detection of articulation disorders with support vector machines and wavelets. ( 17946095 )
2006
12
Assessment of information processing in children with functional articulation disorders. ( 15656956 )
2005
13
Speech summer camp for treating articulation disorders in cleft palate patients. ( 15733594 )
2005
14
A preliminary investigation of the efficacy of oral motor exercises for children with mild articulation disorders. ( 16046921 )
2005
15
Using electropalatography (EPG) to diagnose and treat articulation disorders associated with mild cerebral palsy: a case study. ( 12945612 )
2003
16
Articulation disorders associated with maxillary growth after attainment of normal articulation after primary palatoplasty for cleft palate. ( 11910218 )
2002
17
Linguistic development in cleft palate patients with and without compensatory articulation disorder. ( 10967376 )
2000
18
Wavelet transform in the time-frequency analysis of patients with articulation disorders. ( 10444985 )
1999
19
Relationship of tongue-thrust swallowing and anterior open bite with articulation disorders: a clinical study. ( 10863488 )
1999
20
Atrophy of the tongue with persistent articulation disorder in myasthenia gravis: report of 10 patients. ( 7779022 )
1994
21
Articulation disorders. ( 8292084 )
1993
22
Perception of voiceless fricatives by children with a functional articulation disorder. ( 2709838 )
1989
23
The occurrence of developmental apraxia of speech in a mild articulation disorder: a case study. ( 2794108 )
1989
24
Visual-motor ability of children with articulation disorders. ( 2780195 )
1989
25
Visual training and correction of articulation disorders by use of dynamic palatography: serial observation in a case of cleft palate. ( 3736023 )
1986
26
The relationship between articulation disorders and motor coordination in children. ( 3752221 )
1986
27
An instrumental investigation of articulation disorders in children. ( 7082565 )
1982
28
An articulation disorder in 17th-century Germany. ( 381336 )
1979
29
A comparison of speech-sound production and discrimination in children with functional articulation disorders. ( 732397 )
1978
30
Articulation disorders: from prescription to description. ( 323574 )
1977
31
Psychometric data for the token test derived from 8- and 9-year-old children with articulation disorders. ( 893190 )
1977
32
The use of time-expanded speech as an aid in the diagnosis of articulation disorders. ( 1002850 )
1976
33
The relationship between articulation disorders and self-monitoring auditory discrimination. ( 802984 )
1975
34
The phonological analysis of articulation disorders. ( 1156533 )
1975
35
Psychological implications of articulation disorders in cleft palate children. ( 4509232 )
1972
36
SEVERE ARTICULATION DISORDERS AND MOTOR ABILITY. ( 14210033 )
1964
37
Prognostic testing for functional articulation disorders among children in the first grade. ( 13539889 )
1958
38
Research in articulation disorders and personality. ( 13358106 )
1956

Variations for Articulation Disorder

Expression for Articulation Disorder

Search GEO for disease gene expression data for Articulation Disorder.

Pathways for Articulation Disorder

Pathways related to Articulation Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.11 AP4E1 GNPTAB GNPTG NAGPA SLC17A5

GO Terms for Articulation Disorder

Cellular components related to Articulation Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi apparatus GO:0005794 9.02 AP4E1 CNTNAP2 GNPTAB GNPTG NAGPA
2 synaptic vesicle membrane GO:0030672 8.96 DRD2 SLC17A5

Biological processes related to Articulation Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein localization GO:0008104 9.48 AP4E1 DRD2
2 cerebral cortex development GO:0021987 9.46 CNTNAP2 FOXP2
3 forebrain development GO:0030900 9.43 DRD2 FOXP2
4 lysosome organization GO:0007040 9.4 GNPTAB NAGPA
5 adult behavior GO:0030534 9.37 CNTNAP2 DRD2
6 carbohydrate phosphorylation GO:0046835 9.32 GNPTAB GNPTG
7 striatum development GO:0021756 9.26 CNTNAP2 DRD2
8 vocal learning GO:0042297 9.16 CNTNAP2 FOXP2
9 secretion of lysosomal enzymes GO:0033299 8.96 GNPTAB NAGPA
10 N-glycan processing to lysosome GO:0016256 8.62 GNPTAB GNPTG

Molecular functions related to Articulation Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity GO:0003976 8.62 GNPTAB GNPTG

Sources for Articulation Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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