Articulation Disorder disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Articulation Disorder

MalaCards integrated aliases for Articulation Disorder:

Name: Articulation Disorder ¹² ¹⁵

Articulation Disorders ⁴⁴ ⁷³

Phonological Disorder ¹² ⁷³

Articulation Impairment ¹²

Speech Sound Disorders ⁷³

Classifications:

MalaCards categories:
Anatomical: Mental diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4186

MeSH ⁴⁴ D001184

SNOMED-CT ⁶⁸ 386701004 8187005

UMLS ⁷³ C0003910 C4048283 C4019167

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Summaries for Articulation Disorder

Disease Ontology : ¹² A speech disorder that involves mispronouncing speech sounds by omitting, distorting, substituting, or adding sounds which can make speech difficult to understand.

MalaCards based summary : Articulation Disorder, also known as articulation disorders, is related to childhood apraxia of speech and stuttering. An important gene associated with Articulation Disorder is GNPTG (N-Acetylglucosamine-1-Phosphate Transferase Subunit Gamma), and among its related pathways/superpathways is Lysosome. Affiliated tissues include brain and tongue, and related phenotype is behavior/neurological.

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Related Diseases for Articulation Disorder

Diseases related to Articulation Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)

#	Related Disease	Score	Top Affiliating Genes
1	childhood apraxia of speech	31.9	CNTNAP2 FOXP2
2	stuttering	27.4	AP4E1 CNTNAP2 DRD2 FOXP2 GNPTAB GNPTG
3	inclusion-cell disease	10.4	GNPTAB GNPTG
4	mucolipidosis iii alpha/beta	10.4	GNPTAB GNPTG
5	mucolipidosis ii alpha/beta	10.2	GNPTAB GNPTG
6	reading disorder	10.1	CNTNAP2 FOXP2
7	specific language impairment	9.9	CNTNAP2 FOXP2
8	autosomal recessive disease	9.8	CD55 GNPTAB GNPTG
9	cleft palate, isolated	9.7
10	myasthenia gravis	9.7
11	apraxia	9.7
12	cleft lip	9.7
13	myasthenia gravis congenital	9.7
14	dysphagia	9.7
15	cleft lip/palate	9.7
16	dyslexia	9.7	FOXP2 GNPTAB GNPTG NAGPA
17	speech and communication disorders	9.6	CNTNAP2 FOXP2 GNPTG NAGPA
18	alcohol abuse	9.1	DRD2 SLC17A5
19	speech disorder	8.3	CNTNAP2 FOXP2 GNPTAB GNPTG NAGPA SLC17A5

Graphical network of the top 20 diseases related to Articulation Disorder:

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Symptoms & Phenotypes for Articulation Disorder

MGI Mouse Phenotypes related to Articulation Disorder:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.23	AP4E1 CD55 CNTNAP2 DRD2 GNPTAB PHF21A

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Drugs & Therapeutics for Articulation Disorder

Interventional clinical trials:

(show all 20)

#	Name	Status	NCT ID	Phase
1	Randomized Clinical Trial of Phonological Interventions	Unknown status	NCT00818428	Phase 2, Phase 3
2	Efficacy of Voice Treatment for Parkinson's Disease	Unknown status	NCT00123084	Phase 2
3	Improve Speech Using an In-the-ear Device in Parkinson's Disease	Completed	NCT00488657	Phase 1
4	Dysarthria in Parkinson's Disease: Lusophony vs. Francophony Comparison	Unknown status	NCT02753192	Not Applicable
5	Study of Brain Activity During Speech Production and Speech Perception	Completed	NCT00004991
6	Characteristics of Idiopathic Familial Speech Disorders	Completed	NCT00001551
7	Internal Rotation Deficit of the Glenohumeral Joint in Advanced-level Handball Players	Completed	NCT02011243
8	Study on the Phenotype of Language in Preterm Born Children at 5 Years of Age	Completed	NCT02988570	Not Applicable
9	Study of Speech Disorders , Voice and Swallowing in Primary Dystonia Oromandibular	Completed	NCT03380676
10	Study of Dysarthria, Swallowing Disorders and Respiratory in Parkinson's Disease	Completed	NCT02627664
11	Intensive Dysarthria Sessions in Adults and Children With Down Syndrome	Completed	NCT01684670	Not Applicable
12	New Therapeutical Perspectives in Cases of Phonological Disorders	Recruiting	NCT02935062	Not Applicable
13	Evaluating the Efficacy of Opti-Speech for Speech Treatment	Recruiting	NCT02705326	Not Applicable
14	Study of Dysarthria, and the Appearance of Non-dopaminergic Signs in Idiopathic PARKinson's Disease	Recruiting	NCT03517059
15	The Incidence of Aphasia, Dysarthria and Dysphagia Following Stroke	Recruiting	NCT03472625
16	Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford	Recruiting	NCT01793168
17	Maturation of Auditory Processing in Children With Dyslexia Compared to Average-reading Children	Active, not recruiting	NCT02345876
18	A Comparison of Voice Amplifiers and Personal Communication Systems in Individuals With Parkinson's Disease	Enrolling by invitation	NCT02407067	Not Applicable
19	Acoustic and Perceptual Markers of Dysarthria in Amyotrophic Lateral Sclerosis (ALS)	Not yet recruiting	NCT03560661
20	Characterization of the Profile of Dysarthria in Huntington's Disease, Using the Clinical Evaluation Battery of Dysarthria	Withdrawn	NCT03142217	Not Applicable

Search NIH Clinical Center for Articulation Disorder

Cochrane evidence based reviews: articulation disorders

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Genetic Tests for Articulation Disorder

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Anatomical Context for Articulation Disorder

MalaCards organs/tissues related to Articulation Disorder:

⁴¹

Brain, Tongue

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Publications for Articulation Disorder

Articles related to Articulation Disorder:

#	Title	Authors	Year
1	Speech and Linguistic Features of Children With Articulation Disorder. ( 29201823 )	Kim J....Kim H.I.	2017
2	Structure of a New Palatal Plate and the Artificial Tongue for Articulation Disorder in a Patient with Subtotal Glossectomy. ( 27339210 )	Kozaki K.I....Minagi S.	2016
3	A case of hemangiopericytoma of the soft palate with articulate disorder and dysphagia. ( 23703709 )	Michi Y....Harada K.	2013
4	Automatic detection of articulation disorders in children with cleft lip and palate. ( 19894838 )	Maier A....Schuster M.	2009
5	Linguistic development in cleft palate patients with and without compensatory articulation disorder. ( 10967376 )	Pamplona M.C....PatiA+o C.	2000
6	Atrophy of the tongue with persistent articulation disorder in myasthenia gravis: report of 10 patients. ( 7779022 )	De Assis J.L....Scaff M.	1994
7	Perception of voiceless fricatives by children with a functional articulation disorder. ( 2709838 )	Rvachew S....Jamieson D.G.	1989
8	The occurrence of developmental apraxia of speech in a mild articulation disorder: a case study. ( 2794108 )	Hall P.K.	1989
9	An articulation disorder in 17th-century Germany. ( 381336 )	Wollock J.	1979

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Genes for Articulation Disorder

Genes related to Articulation Disorder (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	GNPTG	N-Acetylglucosamine-1-Phosphate Transferase Subunit Gamma	Protein Coding	18.03	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	NAGPA	N-Acetylglucosamine-1-Phosphodiester Alpha-N-Acetylglucosaminidase	Protein Coding	17.86	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	GNPTAB	N-Acetylglucosamine-1-Phosphate Transferase Subunits Alpha And Beta	Protein Coding	17.62	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	FOXP2	Forkhead Box P2	Protein Coding	16.68	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	16.59	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	SLC17A5	Solute Carrier Family 17 Member 5	Protein Coding	16.2	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	CNTNAP2	Contactin Associated Protein Like 2	Protein Coding	15.93	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	PHF21A	PHD Finger Protein 21A	Protein Coding	15.54	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	AP4E1	Adaptor Related Protein Complex 4 Subunit Epsilon 1	Protein Coding	15.32	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	DRD2	Dopamine Receptor D2	Protein Coding	15.3	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	CD55	CD55 Molecule (Cromer Blood Group)	Protein Coding	15.26	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Articulation Disorder

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Expression for Articulation Disorder

Search GEO for disease gene expression data for Articulation Disorder.

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Pathways for Articulation Disorder

Pathways related to Articulation Disorder according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Lysosome ³⁷	11.11	AP4E1 GNPTAB GNPTG NAGPA SLC17A5

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GO Terms for Articulation Disorder

Cellular components related to Articulation Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Golgi apparatus	GO:0005794	9.02	AP4E1 CNTNAP2 GNPTAB GNPTG NAGPA

Biological processes related to Articulation Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	forebrain development	GO:0030900	9.46	DRD2 FOXP2
2	cerebral cortex development	GO:0021987	9.43	CNTNAP2 FOXP2
3	lysosome organization	GO:0007040	9.4	GNPTAB NAGPA
4	adult behavior	GO:0030534	9.37	CNTNAP2 DRD2
5	carbohydrate phosphorylation	GO:0046835	9.32	GNPTAB GNPTG
6	striatum development	GO:0021756	9.26	CNTNAP2 DRD2
7	vocal learning	GO:0042297	9.16	CNTNAP2 FOXP2
8	secretion of lysosomal enzymes	GO:0033299	8.96	GNPTAB NAGPA
9	N-glycan processing to lysosome	GO:0016256	8.62	GNPTAB GNPTG

Molecular functions related to Articulation Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity	GO:0003976	8.62	GNPTAB GNPTG

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