MCID: ART014
MIFTS: 34

Articulation Disorder

Categories: Mental diseases

Aliases & Classifications for Articulation Disorder

MalaCards integrated aliases for Articulation Disorder:

Name: Articulation Disorder 12 15
Articulation Disorders 44 70
Phonological Disorder 12 70
Articulation Impairment 12
Speech Sound Disorders 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4186
MeSH 44 D001184
SNOMED-CT 67 8187005
UMLS 70 C0003910 C4019167 C4048283

Summaries for Articulation Disorder

Disease Ontology : 12 A speech disorder that involves mispronouncing speech sounds by omitting, distorting, substituting, or adding sounds which can make speech difficult to understand.

MalaCards based summary : Articulation Disorder, also known as articulation disorders, is related to childhood apraxia of speech and speech and communication disorders. An important gene associated with Articulation Disorder is NAGPA (N-Acetylglucosamine-1-Phosphodiester Alpha-N-Acetylglucosaminidase), and among its related pathways/superpathways are Lysosome and MECP2 and Associated Rett Syndrome. The drugs tannic acid and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include tongue, brain and temporal lobe, and related phenotype is normal.

Related Diseases for Articulation Disorder

Diseases related to Articulation Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 childhood apraxia of speech 32.2 FOXP2 CNTNAP2
2 speech and communication disorders 29.6 NAGPA GNPTG FOXP2 CNTNAP2 CEBPD ATP2C2
3 movement disease 29.6 GAD1 DRD2 CNTNAP2
4 dyslexia 29.2 NAGPA GNPTG GNPTAB FOXP2 DRD2 CNTNAP2
5 stuttering 29.2 SST PVALB PDE5A NAGPA MT-CYB LINC01554
6 speech disorder 27.9 SST PVALB NAGPA MT-CYB LINC01554 GNPTG
7 abnormal hair, joint laxity, and developmental delay 11.0
8 tarsal tunnel syndrome 10.4 GNPTG GNPTAB
9 tibial neuropathy 10.4 GNPTG GNPTAB
10 mucolipidoses 10.4 GNPTG GNPTAB
11 pediculus humanus capitis infestation 10.3 MT-CYB LINC01554
12 hurler syndrome 10.3 NAGPA GNPTG GNPTAB
13 mucolipidosis iii alpha/beta 10.3 NAGPA GNPTG GNPTAB
14 mucolipidosis 10.3 NAGPA GNPTG GNPTAB
15 mucolipidosis ii alpha/beta 10.3 NAGPA GNPTG GNPTAB
16 mucopolysaccharidosis-plus syndrome 10.3 NAGPA GNPTG GNPTAB
17 breast fibrosarcoma 10.3 PVALB CALB1
18 osteogenesis imperfecta, type vii 10.3 GNPTAB GAD1
19 mucolipidosis iii gamma 10.2 GNPTG GNPTAB
20 paroxysmal dystonia 10.2 SST PVALB CALB2
21 pitt-hopkins-like syndrome 1 10.2 CNTNAP2 AP4E1
22 echolalia 10.2 FOXP2 CNTNAP2 CEBPD
23 tic disorder 10.2 PVALB DRD2 CNTNAP2
24 expressive language disorder 10.2 FOXP2 CEBPD ATP2C2
25 learning disability 10.2 FOXP2 CNTNAP2 CEBPD
26 developmental coordination disorder 10.2 CEBPD ATP2C2
27 diamond-blackfan anemia 5 10.1 SST PVALB
28 choreatic disease 10.1 PVALB DRD2 CNTNAP2
29 temporal lobe epilepsy 10.1 PVALB GAD1 CALB1
30 dysphagia 10.1
31 gilles de la tourette syndrome 10.1 PVALB DRD2 CNTNAP2
32 cleft lip 10.1
33 cleft lip/palate 10.1
34 status epilepticus 10.1 SST PVALB CALB2 CALB1
35 optic nerve disease 10.1 PDE5A MT-CYB DCAF8
36 kagami-ogata syndrome 10.1 PVALB GAD1 DRD2 CALB1
37 early infantile epileptic encephalopathy 10.0 SST PVALB GAD1 CNTNAP2
38 cleft palate, isolated 10.0
39 apraxia 10.0
40 cerebral palsy 10.0
41 specific developmental disorder 10.0 PVALB FOXP2 DRD2 DCAF8 CNTNAP2
42 benign epilepsy with centrotemporal spikes 10.0 FOXP2 CNTNAP2 CEBPD ATP2C2
43 pervasive developmental disorder 10.0 PVALB GAD1 FOXP2 DRD2 CNTNAP2
44 reading disorder 9.9 NAGPA FOXP2 CNTNAP2 CEBPD ATP2C2
45 rett syndrome 9.9 SST GAD1 DRD2 CEBPD
46 dystonia 9.9 SST PVALB MT-CYB DRD2 CALB2
47 major depressive disorder 9.9 SST PVALB GAD1 DRD2
48 epilepsy, familial temporal lobe, 8 9.9 GAD1 DRD2
49 brain injury 9.9
50 hypotonia 9.9

Graphical network of the top 20 diseases related to Articulation Disorder:



Diseases related to Articulation Disorder

Symptoms & Phenotypes for Articulation Disorder

MGI Mouse Phenotypes related to Articulation Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.23 CALB1 CALB2 DRD2 GAD1 GNPTAB PDE5A

Drugs & Therapeutics for Articulation Disorder

Drugs for Articulation Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved 1401-55-4
2
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
3
Silver sulfadiazine Approved, Vet_approved 22199-08-2 441244

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 The Contribution of a Speech Perception Intervention to the Prevention of Phonological Awareness Deficits in Children With Speech Sound Disorders Unknown status NCT00818428 Phase 2, Phase 3
2 Correcting Residual Errors With Spectral, Ultrasound, and Traditional Speech Therapy: A Randomized Controlled Trial Recruiting NCT03737318 Phase 2
3 Biofeedback and Speech Disorders Completed NCT01905449 Phase 1
4 staRt: Enhancing Speech Treatment With Smartphone-delivered Biofeedback Completed NCT04474691 Phase 1
5 Correcting Residual Errors With Spectral, Ultrasound, and Traditional Speech Therapy: Delineation of Sensorimotor Subtypes Recruiting NCT03736213 Phase 1
6 Comparing Traditional and Biofeedback Treatment for Residual Speech Errors Via Telepractice Recruiting NCT04625062 Phase 1
7 Early Intervention for Speech Sound Disorder in Very Preterm Children Unknown status NCT01352481
8 New Therapeutical Perspectives in Cases of Phonological Disorders Completed NCT02935062
9 Age-related Correlates of Treatment Efficacy and Efficiency for Late-acquired Sounds Completed NCT03663972
10 Evaluating the Efficacy of Opti-Speech, a 3D Visual Feedback System, for Speech Treatment Completed NCT02705326
11 Characteristics of Idiopathic Familial Speech Disorders Completed NCT00001551
12 Brain Activation During Developmental Speech Production and Speech Perception Completed NCT00004991
13 Intervention Software for Children With Speech Sound Disorders Completed NCT02490826
14 Formulatin and Application of a Remediation Software Porgram for Correction of Articulatory Errors in Patients With Velopfaryngeal Dysfunction Completed NCT04392817
15 Evaluation of the Internal Rotation Deficit of the Glenohumeral Joint in Advanced-level Handball Players Occurring Over One Training Season Completed NCT02011243
16 Influence of a Intervention Break on a Treated Phonological Process in Spontaneous Speech Situations in Children Aged 5 to 6 Years With Phonologically Delayed Development Recruiting NCT03972891
17 Efficacy of an Intervention for the Children With Severe Speech Sounds Disorders Recruiting NCT03700151
18 A Developmental Framework For Linking Phonological And Morpho-syntactic Sequential Pattern Rules In Developmental Language Disorder: Production Recruiting NCT04558541 Early Phase 1
19 Identification of Electrophysiological Indices of Speech Sound Perception and Change in Children With Speech Sound Disorders Active, not recruiting NCT03623100
20 The Impact of Beatboxing on the Management of Individuals With Residual Speech Errors Not yet recruiting NCT03972449
21 How to Promote Children's Language Development Using Family-based Shared Book Reading: Study B; Examining the Effect of Training Shared Reading Practice, With Form-emphasising Books, on Children's Language and Phonological Awareness Withdrawn NCT03006744

Search NIH Clinical Center for Articulation Disorder

Cochrane evidence based reviews: articulation disorders

Genetic Tests for Articulation Disorder

Anatomical Context for Articulation Disorder

MalaCards organs/tissues related to Articulation Disorder:

40
Tongue, Brain, Temporal Lobe, Cortex, Bone, Breast, Prostate

Publications for Articulation Disorder

Articles related to Articulation Disorder:

(show top 50) (show all 212)
# Title Authors PMID Year
1
Contralateral suppression of transient evoked otoacoustic emissions in children with phonological disorder. 61
33283490 2021
2
Differential Diagnosis of Childhood Apraxia of Speech Compared to Other Speech Sound Disorders: A Systematic Review. 61
33151751 2021
3
"It Is Not the Robot Who Learns, It Is Me." Treating Severe Dysgraphia Using Child-Robot Interaction. 61
33716812 2021
4
Application of childhood apraxia of speech clinical markers to French-speaking children: A preliminary study. 61
33666129 2020
5
Mismatch Negativity in children with Phonological Disorders. 61
33080473 2020
6
Association between phonation and the vowel quadrilateral in patients with stroke: A retrospective observational study. 61
32991418 2020
7
An accessory tongue in a child: A clinical case. 61
32819761 2020
8
Predicting speech-sound disorder outcomes in school-age children with hearing loss: The VicCHILD experience. 61
32374456 2020
9
Speech-language therapy students' auditory-perceptual judgements of simulated concurrent hypernasality and articulation disorders. 61
31429313 2020
10
Evidence for [Coronal] Underspecification in Typical and Atypical Phonological Development. 61
33414710 2020
11
Indicators of speech fluency in stuttering and in phonological disorder. 61
32267336 2020
12
The Neurocognition of Developmental Disorders of Language. 61
31337273 2020
13
The application of the maximal opposition therapy approach to an Arabic-speaking child. 61
31279082 2019
14
Correlations Between Values of Articulation Tests and Language Tests for Children With Articulation Disorder in Korea. 61
31499602 2019
15
Acute onset bilateral hearing loss in dorsomedial pontine hemorrhage: A Case report. 61
31441869 2019
16
Analysis of the components of Frequency-Following Response in phonological disorders. 61
30959337 2019
17
Is excessive visual crowding causally linked to developmental dyslexia? 61
31077708 2019
18
Validation of Dodd's Model for Differential Diagnosis of childhood speech sound disorders: a longitudinal community cohort study. 61
30151900 2019
19
Treatment Targets for Co-Occurring Speech-Language Impairment: A Case Study. 61
31214657 2019
20
Speech and language in children with Klinefelter syndrome. 61
30822601 2019
21
Lambdacism, Rhotacism and Sigmatism in Preschool Children: Frequency and Distribution. 61
30833997 2019
22
Quantifying phonological knowledge in children with phonological disorder. 61
31379215 2019
23
Pseudowords to the Phonological Therapy: a new therapeutic approach. 61
30517266 2018
24
Treatment of Phonological Disorder: A Feasibility Study With Focus on Outcome Measures. 61
29466550 2018
25
The phonological memory profile of preschool children who make atypical speech sound errors. 61
28590148 2018
26
Cerebral Hemodynamics in Speech-Related Cortical Areas: Articulation Learning Involves the Inferior Frontal Gyrus, Ventral Sensory-Motor Cortex, and Parietal-Temporal Sylvian Area. 61
30443239 2018
27
Performance of children with speech sound disorders in the dynamic evaluation of motor speech skills. 61
29791618 2018
28
Paediatric Automatic Phonological Analysis Tools (APAT). 61
27724177 2017
29
Pure apraxia of speech due to infarct in premotor cortex. 61
28844393 2017
30
Lingual alveolar soft part sarcoma responsive to pazopanib: A case report. 61
29095301 2017
31
Prevalence of speech and language disorders in children in the western region of São Paulo. 61
29160334 2017
32
Speech profile of patients undergoing primary palatoplasty. 61
29091112 2017
33
Speech and Linguistic Features of Children With Articulation Disorder. 61
29201823 2017
34
Increased activation of the hippocampus during a Chinese character subvocalization task in adults with cleft lip and palate palatoplasty and speech therapy. 61
28658048 2017
35
Phonologic and Acoustic Analysis of Speech Following Glossectomy and the Effect of Rehabilitation on Speech Outcomes. 61
28039737 2017
36
Transient hypoglossal nerve palsy after transoral intubation for general anesthesia. 61
28811811 2017
37
Longitudinal follow-up to evaluate speech disorders in early-treated patients with infantile-onset Pompe disease. 61
28039015 2017
38
Potocki-Shaffer syndrome in a child without intellectual disability-The role of PHF21A in cognitive function. 61
28127865 2017
39
[Phonological characteristics and rehabilitation training of abnormal velar in children with functional articulation disorders]. 61
28318160 2016
40
[Property analysis of the finals mispronunciation in Chinese-speaking children with functional articulation disorder]. 61
27784477 2016
41
[Temporomandibular joint septic arthritis with secondary condylar resorption]. 61
27522243 2016
42
Out-of-synchrony speech entrainment in developmental dyslexia. 61
27061643 2016
43
Structure of a New Palatal Plate and the Artificial Tongue for Articulation Disorder in a Patient with Subtotal Glossectomy. 61
27339210 2016
44
Tongue displacement and durational characteristics of normal and disordered Brazilian Portuguese liquids. 61
26853548 2016
45
Successful and rapid response of speech bulb reduction program combined with speech therapy in velopharyngeal dysfunction: a case report. 61
26258115 2015
46
A Randomized Trial of 12-Week Interventions for the Treatment of Developmental Phonological Disorder in Francophone Children. 61
26381229 2015
47
Changes of some functional speech disorders after surgical correction of skeletal anterior open bite. 61
26164798 2015
48
Word production inconsistency of Singaporean-English-speaking adolescents with Down Syndrome. 61
26149647 2015
49
Speech rate and fluency in children with phonological disorder. 61
26398256 2015
50
Phonemic discrimination and the relationship with other linguistic levels in children with typical phonological development and phonological disorder. 61
26222939 2015

Variations for Articulation Disorder

Expression for Articulation Disorder

Search GEO for disease gene expression data for Articulation Disorder.

Pathways for Articulation Disorder

Pathways related to Articulation Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.03 NAGPA GNPTG GNPTAB AP4E1
2 10.92 SST GAD1 CEBPD

GO Terms for Articulation Disorder

Cellular components related to Articulation Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 synapse GO:0045202 9.73 SST GAD1 DRD2 CALB2 CALB1 ARHGDIA
2 axon GO:0030424 9.55 PVALB GAD1 DRD2 CNTNAP2 CALB1
3 stereocilium GO:0032420 9.13 PVALB CALB2 CALB1
4 cuticular plate GO:0032437 8.8 PVALB CALB2 CALB1

Biological processes related to Articulation Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.62 SST MT-CYB GAD1 DRD2
2 carbohydrate phosphorylation GO:0046835 9.37 GNPTG GNPTAB
3 regulation of presynaptic cytosolic calcium ion concentration GO:0099509 9.26 CALB2 CALB1
4 regulation of long-term synaptic potentiation GO:1900271 9.16 CALB2 CALB1
5 striatum development GO:0021756 8.96 DRD2 CNTNAP2
6 secretion of lysosomal enzymes GO:0033299 8.62 NAGPA GNPTAB

Molecular functions related to Articulation Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity GO:0003976 8.96 GNPTG GNPTAB
2 calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration GO:0099534 8.62 CALB2 CALB1

Sources for Articulation Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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