MCID: ART014
MIFTS: 35

Articulation Disorder

Categories: Mental diseases

Aliases & Classifications for Articulation Disorder

MalaCards integrated aliases for Articulation Disorder:

Name: Articulation Disorder 12 15
Articulation Disorders 43 71
Phonological Disorder 12 71
Articulation Impairment 12
Speech Sound Disorders 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4186
MeSH 43 D001184
UMLS 71 C0003910 C4019167 C4048283

Summaries for Articulation Disorder

Disease Ontology : 12 A speech disorder that involves mispronouncing speech sounds by omitting, distorting, substituting, or adding sounds which can make speech difficult to understand.

MalaCards based summary : Articulation Disorder, also known as articulation disorders, is related to speech and communication disorders and specific language impairment. An important gene associated with Articulation Disorder is LINC01554 (Long Intergenic Non-Protein Coding RNA 1554), and among its related pathways/superpathways are Lysosome and IL10 Signaling Pathway. The drugs tannic acid and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and tongue, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Related Diseases for Articulation Disorder

Diseases related to Articulation Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 speech and communication disorders 30.6 GNPTG GNAS-AS1 FOXP2
2 specific language impairment 30.3 NAGPA GNPTG FOXP2
3 dyslexia 30.0 NAGPA GNPTG GNPTAB FOXP2
4 stuttering 29.1 SST SOCS6 SOCS3 SLC22A12 PVALB PLEKHB2
5 speech disorder 28.6 SOCS6 SOCS3 PVALB NAGPA LINC01554 HHEX
6 childhood apraxia of speech 11.4
7 abnormal hair, joint laxity, and developmental delay 11.1
8 renal pelvis squamous cell carcinoma 10.4 PVALB HHEX
9 pediculus humanus corporis infestation 10.3 MT-CYB LINC01554
10 mucolipidosis iii alpha/beta 10.3 NAGPA GNPTG GNPTAB
11 mucolipidosis 10.3 NAGPA GNPTG GNPTAB
12 cleft palate, isolated 10.3
13 mucolipidosis ii alpha/beta 10.3 NAGPA GNPTG GNPTAB
14 hurler syndrome 10.3 GNPTG GNPTAB
15 oesophagostomiasis 10.2 MT-CYB EPGN
16 cavitary optic disc anomalies 10.2
17 paroxysmal dystonia 10.2 SST PVALB
18 dysphagia 10.2
19 myasthenic syndrome, congenital, 10 10.1 MT-CYB LINC01554 FST ARHGDIA
20 apraxia 10.1
21 cleft lip 10.1
22 cleft lip/palate 10.1
23 learning disability 10.1
24 congenital myasthenic syndrome 10.0 MT-CYB LINC01554 FST ARHGDIA
25 aphasia 10.0
26 cerebral palsy 10.0
27 jacobsen syndrome 9.9
28 epilepsy, focal, with speech disorder and with or without mental retardation 9.9
29 dysphasia, familial developmental 9.9
30 thrombocytopenia 9.9
31 landau-kleffner syndrome 9.9
32 dysgraphia 9.9
33 brain injury 9.9
34 hypotonia 9.9
35 traumatic brain injury 9.9
36 attention deficit-hyperactivity disorder 9.8
37 facioscapulohumeral muscular dystrophy 1 9.8
38 hemangiopericytoma, malignant 9.8
39 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.8
40 myasthenia gravis 9.8
41 meningioma, radiation-induced 9.8
42 meningioma, familial 9.8
43 bone resorption disease 9.8
44 suppression amblyopia 9.8
45 amblyopia 9.8
46 amnestic disorder 9.8
47 hemiplegia 9.8
48 spinal meningioma 9.8
49 quadriplegia 9.8
50 secretory meningioma 9.8

Graphical network of the top 20 diseases related to Articulation Disorder:



Diseases related to Articulation Disorder

Symptoms & Phenotypes for Articulation Disorder

MGI Mouse Phenotypes related to Articulation Disorder:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.81 AP4E1 ARHGDIA EPGN FST GAD1 GNPTAB
2 hematopoietic system MP:0005397 9.65 AP4E1 ARHGDIA EPGN GNPTAB HEPHL1 HHEX
3 homeostasis/metabolism MP:0005376 9.44 AP4E1 ARHGDIA EPGN FST GAD1 GNPTAB

Drugs & Therapeutics for Articulation Disorder

Drugs for Articulation Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved 1401-55-4
2
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
3
Silver sulfadiazine Approved, Vet_approved 22199-08-2 441244

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 The Contribution of a Speech Perception Intervention to the Prevention of Phonological Awareness Deficits in Children With Speech Sound Disorders Unknown status NCT00818428 Phase 2, Phase 3
2 Biofeedback and Speech Disorders Completed NCT01905449 Phase 1
3 New Therapeutical Perspectives in Cases of Phonological Disorders Completed NCT02935062
4 Brain Activation During Developmental Speech Production and Speech Perception Completed NCT00004991
5 Evaluating the Efficacy of Opti-Speech, a 3D Visual Feedback System, for Speech Treatment Completed NCT02705326
6 Characteristics of Idiopathic Familial Speech Disorders Completed NCT00001551
7 Intervention Software for Children With Speech Sound Disorders Completed NCT02490826
8 Treatment Efficacy for Developmental Motor Speech Disorders: A PROMPT Randomized Control Trial Completed NCT02105402
9 Asymmetry, Auditory Processing and Reading Skills in Phonological Dyslexic Children Compared to Average-reading Children Completed NCT02345876
10 Formulatin and Application of a Remediation Software Porgram for Correction of Articulatory Errors in Patients With Velopfaryngeal Dysfunction Completed NCT04392817
11 Age-related Correlates of Treatment Efficacy and Efficiency for Late-acquired Sounds Completed NCT03663972
12 Evaluation of the Internal Rotation Deficit of the Glenohumeral Joint in Advanced-level Handball Players Occurring Over One Training Season Completed NCT02011243
13 Apraxia of Speech: A Comparison of EPG Treatment & Sound Production Treatment Completed NCT02554513
14 The Effect of Different Feeding Methods and Non-nutritive Sucking Behaviours on Child Speech Development Recruiting NCT03315416
15 Influence of a Intervention Break on a Treated Phonological Process in Spontaneous Speech Situations in Children Aged 5 to 6 Years With Phonologically Delayed Development Recruiting NCT03972891
16 Identification of Electrophysiological Indices of Speech Sound Perception and Change in Children With Speech Sound Disorders Recruiting NCT03623100
17 Efficacy of an Intervention for the Children With Severe Speech Sounds Disorders Recruiting NCT03700151
18 Manipulating Linguistic Complexity to Improve Child Language Treatment Outcomes Recruiting NCT03977701
19 The Impact of Beatboxing on the Management of Individuals With Residual Speech Errors Not yet recruiting NCT03972449 Early Phase 1

Search NIH Clinical Center for Articulation Disorder

Cochrane evidence based reviews: articulation disorders

Genetic Tests for Articulation Disorder

Anatomical Context for Articulation Disorder

MalaCards organs/tissues related to Articulation Disorder:

40
Brain, Testes, Tongue, Cortex, Bone, Lung, Prostate

Publications for Articulation Disorder

Articles related to Articulation Disorder:

(show top 50) (show all 204)
# Title Authors PMID Year
1
Predicting speech-sound disorder outcomes in school-age children with hearing loss: The VicCHILD experience. 61
32374456 2020
2
Speech-language therapy students' auditory-perceptual judgements of simulated concurrent hypernasality and articulation disorders. 61
31429313 2020
3
The Neurocognition of Developmental Disorders of Language. 61
31337273 2020
4
Indicators of speech fluency in stuttering and in phonological disorder. 61
32267336 2020
5
The application of the maximal opposition therapy approach to an Arabic-speaking child. 61
31279082 2019
6
Acute onset bilateral hearing loss in dorsomedial pontine hemorrhage: A Case report. 61
31441869 2019
7
Correlations Between Values of Articulation Tests and Language Tests for Children With Articulation Disorder in Korea. 61
31499602 2019
8
Is excessive visual crowding causally linked to developmental dyslexia? 61
31077708 2019
9
Analysis of the components of Frequency-Following Response in phonological disorders. 61
30959337 2019
10
Validation of Dodd's Model for Differential Diagnosis of childhood speech sound disorders: a longitudinal community cohort study. 61
30151900 2019
11
Treatment Targets for Co-Occurring Speech-Language Impairment: A Case Study. 61
31214657 2019
12
Speech and language in children with Klinefelter syndrome. 61
30822601 2019
13
Lambdacism, Rhotacism and Sigmatism in Preschool Children: Frequency and Distribution. 61
30833997 2019
14
Quantifying phonological knowledge in children with phonological disorder. 61
31379215 2019
15
Pseudowords to the Phonological Therapy: a new therapeutic approach. 61
30517266 2018
16
Treatment of Phonological Disorder: A Feasibility Study With Focus on Outcome Measures. 61
29466550 2018
17
Cerebral Hemodynamics in Speech-Related Cortical Areas: Articulation Learning Involves the Inferior Frontal Gyrus, Ventral Sensory-Motor Cortex, and Parietal-Temporal Sylvian Area. 61
30443239 2018
18
Performance of children with speech sound disorders in the dynamic evaluation of motor speech skills. 61
29791618 2018
19
The phonological memory profile of preschool children who make atypical speech sound errors. 61
28590148 2018
20
Paediatric Automatic Phonological Analysis Tools (APAT). 61
27724177 2017
21
Pure apraxia of speech due to infarct in premotor cortex. 61
28844393 2017
22
Prevalence of speech and language disorders in children in the western region of São Paulo. 61
29160334 2017
23
Lingual alveolar soft part sarcoma responsive to pazopanib: A case report. 61
29095301 2017
24
Speech profile of patients undergoing primary palatoplasty. 61
29091112 2017
25
Speech and Linguistic Features of Children With Articulation Disorder. 61
29201823 2017
26
Increased activation of the hippocampus during a Chinese character subvocalization task in adults with cleft lip and palate palatoplasty and speech therapy. 61
28658048 2017
27
Phonologic and Acoustic Analysis of Speech Following Glossectomy and the Effect of Rehabilitation on Speech Outcomes. 61
28039737 2017
28
Transient hypoglossal nerve palsy after transoral intubation for general anesthesia. 61
28811811 2017
29
Longitudinal follow-up to evaluate speech disorders in early-treated patients with infantile-onset Pompe disease. 61
28039015 2017
30
Potocki-Shaffer syndrome in a child without intellectual disability-The role of PHF21A in cognitive function. 61
28127865 2017
31
[Phonological characteristics and rehabilitation training of abnormal velar in children with functional articulation disorders]. 61
28318160 2016
32
[Property analysis of the finals mispronunciation in Chinese-speaking children with functional articulation disorder]. 61
27784477 2016
33
[Temporomandibular joint septic arthritis with secondary condylar resorption]. 61
27522243 2016
34
Out-of-synchrony speech entrainment in developmental dyslexia. 61
27061643 2016
35
Structure of a New Palatal Plate and the Artificial Tongue for Articulation Disorder in a Patient with Subtotal Glossectomy. 61
27339210 2016
36
Tongue displacement and durational characteristics of normal and disordered Brazilian Portuguese liquids. 61
26853548 2016
37
Successful and rapid response of speech bulb reduction program combined with speech therapy in velopharyngeal dysfunction: a case report. 61
26258115 2015
38
A Randomized Trial of 12-Week Interventions for the Treatment of Developmental Phonological Disorder in Francophone Children. 61
26381229 2015
39
Changes of some functional speech disorders after surgical correction of skeletal anterior open bite. 61
26164798 2015
40
Word production inconsistency of Singaporean-English-speaking adolescents with Down Syndrome. 61
26149647 2015
41
Speech rate and fluency in children with phonological disorder. 61
26398256 2015
42
Phonemic discrimination and the relationship with other linguistic levels in children with typical phonological development and phonological disorder. 61
26222939 2015
43
Slow speech rate effects on stuttering preschoolers with disordered phonology. 61
25651198 2015
44
Effectiveness of tongue-tie division for speech disorder in children. 61
25142274 2015
45
Differential Diagnosis of Speech Sound Disorder (Phonological Disorder): Audiological Assessment beyond the Pure-tone Audiogram. 61
25879245 2015
46
Non-speech oral motor treatment for children with developmental speech sound disorders. 61
25805060 2015
47
Association between audiological profile and primary language impairment in children. 61
25433374 2015
48
The relationship of vocal tract dimensions and substitution of the palatal approximant /j/ for the alveolar trill /r/. 61
25861878 2015
49
Using PhonBank and Phon in studies of phonological development and disorders. 61
26035223 2015
50
[Correlative factors on the articulation disorder of patients with cleft palate]. 61
25490816 2014

Variations for Articulation Disorder

Expression for Articulation Disorder

Search GEO for disease gene expression data for Articulation Disorder.

Pathways for Articulation Disorder

Pathways related to Articulation Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.03 NAGPA GNPTG GNPTAB AP4E1
2 10.42 SOCS6 SOCS3

GO Terms for Articulation Disorder

Cellular components related to Articulation Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol 3-kinase complex GO:0005942 8.62 SOCS6 SOCS3

Biological processes related to Articulation Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 JAK-STAT cascade GO:0007259 9.32 SOCS6 SOCS3
2 carbohydrate phosphorylation GO:0046835 9.26 GNPTG GNPTAB
3 response to drug GO:0042493 9.26 SST SLC22A12 MT-CYB GAD1
4 regulation of phosphatidylinositol 3-kinase activity GO:0043551 9.16 SOCS6 SOCS3
5 secretion of lysosomal enzymes GO:0033299 8.62 NAGPA GNPTAB

Molecular functions related to Articulation Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 1-phosphatidylinositol-3-kinase regulator activity GO:0046935 8.96 SOCS6 SOCS3
2 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity GO:0003976 8.62 GNPTG GNPTAB

Sources for Articulation Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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