AHHI
MCID: ARY002
MIFTS: 24

Aryl Hydrocarbon Hydroxylase Inducibility (AHHI)

Aliases & Classifications for Aryl Hydrocarbon Hydroxylase Inducibility

MalaCards integrated aliases for Aryl Hydrocarbon Hydroxylase Inducibility:

Name: Aryl Hydrocarbon Hydroxylase Inducibility 57 29 70
Ahh Inducibility 57 54
Ahh Inducibility; Ahhi 57
Ahhi 57

External Ids:

OMIM® 57 108340
UMLS 70 C1862463

Summaries for Aryl Hydrocarbon Hydroxylase Inducibility

MalaCards based summary : Aryl Hydrocarbon Hydroxylase Inducibility, also known as ahh inducibility, is related to oropharynx cancer and bladder cancer. An important gene associated with Aryl Hydrocarbon Hydroxylase Inducibility is CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Affiliated tissues include lung, placenta and skin.

More information from OMIM: 108340

Related Diseases for Aryl Hydrocarbon Hydroxylase Inducibility

Diseases related to Aryl Hydrocarbon Hydroxylase Inducibility via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 oropharynx cancer 10.4
2 bladder cancer 10.2
3 lung cancer 10.2
4 leukemia, acute lymphoblastic 10.2
5 gastric cancer 10.2
6 acute leukemia 10.2
7 larynx cancer 10.2
8 childhood leukemia 10.2
9 oral cancer 10.2
10 toxic oil syndrome 9.8 CYP1A1 AHR
11 endometriosis 9.6 CYP1A1 AHRR
12 male infertility 9.5 CYP1A1 AHRR
13 infertility 9.4 CYP1A1 AHRR

Graphical network of the top 20 diseases related to Aryl Hydrocarbon Hydroxylase Inducibility:



Diseases related to Aryl Hydrocarbon Hydroxylase Inducibility

Symptoms & Phenotypes for Aryl Hydrocarbon Hydroxylase Inducibility

Clinical features from OMIM®:

108340 (Updated 20-May-2021)

Drugs & Therapeutics for Aryl Hydrocarbon Hydroxylase Inducibility

Search Clinical Trials , NIH Clinical Center for Aryl Hydrocarbon Hydroxylase Inducibility

Genetic Tests for Aryl Hydrocarbon Hydroxylase Inducibility

Genetic tests related to Aryl Hydrocarbon Hydroxylase Inducibility:

# Genetic test Affiliating Genes
1 Aryl Hydrocarbon Hydroxylase Inducibility 29

Anatomical Context for Aryl Hydrocarbon Hydroxylase Inducibility

MalaCards organs/tissues related to Aryl Hydrocarbon Hydroxylase Inducibility:

40
Lung, Placenta, Skin, Liver, Prostate

Publications for Aryl Hydrocarbon Hydroxylase Inducibility

Articles related to Aryl Hydrocarbon Hydroxylase Inducibility:

(show top 50) (show all 94)
# Title Authors PMID Year
1
A twin study of aryl hydrocarbon hydroxylase (AHH) inducibility in cultured lymphocytes. 61 57
6944164 1981
2
Aryl hydrocarbon hydroxylase in cultured lymphocytes of twins. 61 57
569973 1978
3
Aryl-hydrocarbon-hydroxylase inducibility in patients with cancer. 61 57
76021 1978
4
Questionable relation of aryl hydrocarbon hydroxylase to lung-cancer risk. 61 57
876325 1977
5
Letter: Aryl hydrocarbon hydroxylase inducibility and laryngeal carcinomas. 61 57
59196 1976
6
Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma. 61 57
4126515 1973
7
Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytes. 57
6291746 1982
8
Human skin aryl hydrocarbon hydroxylase. Induction by coal tar. 57
711851 1978
9
Inducibility of aryl hydrocarbon hydroxylase in cultured human lymphocytes: a study of repeatability. 57
353284 1978
10
Ah locus: genetic differences in susceptibility to cataracts induced by acetaminophen. 57
644313 1978
11
Genetic variation of aryl hydrocarbon hydroxylase in human lymphocytes. 57
4704864 1973
12
Aryl hydrocarbon hydroxylase induction in human leukocytes. 57
5078252 1972
13
[Role of metabolic polymorphisms in lung carcinogenesis]. 54 61
10491856 1999
14
The relationship between CYP1A1 aryl hydrocarbon hydroxylase activity and lung cancer in a Japanese population. 54 61
9731718 1998
15
Environmental factors and aryl hydrocarbon hydroxylase activity (CYP1A1 phenotype) in human lymphocytes. 54 61
9465551 1997
16
The relationship between aryl hydrocarbon hydroxylase and polymorphisms of the CYP1A1 gene. 54 61
8609043 1996
17
Effects of polychlorinated dibenzo-p-dioxin and dibenzofuran congeners in human lymphoblastoid cells on aryl hydrocarbon hydroxylase activity. 61 54
8528652 1995
18
Polymorphisms of human Ah receptor gene are not involved in lung cancer. 54 61
7550366 1995
19
Genetic polymorphisms of drug-metabolizing enzymes and lung cancer susceptibility. 61 54
7581493 1995
20
[A role of aryl hydrocarbon hydroxylase inducibility in susceptibility to lung carcinogenesis]. 61 54
8126925 1994
21
Aryl hydrocarbon hydroxylase activity in human placenta and threatened preterm delivery. 54 61
9857304 1993
22
Comparison of pulmonary DNA adduct levels, measured by 32P-postlabelling and aryl hydrocarbon hydroxylase activity in lung parenchyma of smokers and ex-smokers. 61 54
2070496 1991
23
[Role of aryl hydrocarbon hydroxylase in developing laryngeal cancer among smokers]. 54 61
1811685 1991
24
[The role of aromatic hydrocarbon hydroxylase in the pathogenesis of lung cancer]. 54 61
2235714 1990
25
Pulmonary drug-metabolizing enzyme in alveolar macrophages in relation to cigarette smoking. 61 54
2232364 1990
26
The relationship between aryl hydrocarbon hydroxylase activity and DNA adducts measured by (32)P-postlabelling assay in lymphocytes of lung cancer patients. 61
23885952 2000
27
32P-postlabeling detection of aromatic adducts in the white blood cell DNA of nonsmoking police officers. 61
9456236 1998
28
A molecular epidemiological case-control study of lung cancer. 61
7655328 1995
29
Acquisition of aryl hydrocarbon hydroxylase inducibility by aromatic hydrocarbons in monolayer-cultured hepatocytes from nonresponsive mouse strains. 61
1692256 1990
30
Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. 61
2743334 1989
31
Suppression of aryl hydrocarbon hydroxylase activity in human primary lung carcinoma x mouse hepatoma somatic cell hybrids. 61
2818604 1989
32
[Effects of dioxin congeners on aryl hydrocarbon hydroxylase activity]. 61
2744682 1989
33
Induction of cytochrome P450IA1 in mouse hepatoma cells by several chemicals. Phenobarbital and TCDD induce the same form of cytochrome P450. 61
2541728 1989
34
[Mechanism of the mutagenic/carcinogenic action of cigarette smoke at the pulmonary level: enzymatic induction, activation and detoxification]. 61
2483074 1989
35
Pedigree analysis of aryl hydrocarbon hydroxylase inducibility in acute leukemia of childhood. 61
2796383 1989
36
Clastogenic effects of benzo[a]pyrene in postimplantation embryos with different genetic background. 61
2576817 1989
37
Role of the 4-5S binding protein in the induction of aryl hydrocarbon hydroxylase in the rat. 61
3402044 1988
38
A third genetic locus affecting the Ah (dioxin) receptor. 61
2839475 1988
39
Enzyme induction in rat lung and liver by condensates and fractions from main-stream and side-stream cigarette smoke. 61
3691449 1987
40
Regulation of cytochrome P-450c in differentiated and dedifferentiated rat hepatoma cells: role of the Ah receptor. 61
2821631 1987
41
Aryl hydrocarbon hydroxylase in lymphocytes and lung tissue from lung cancer patients and controls. 61
3570549 1987
42
Laryngeal cancer, aryl hydrocarbon hydroxylase inducibility and smoking. A follow-up study. 61
3627733 1987
43
Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin: ontogeny in chick embryo liver. 61
2856072 1986
44
DNA-mediated restoration of aryl hydrocarbon hydroxylase induction in a mouse hepatoma mutant defective in nuclear translocation of the Ah receptor. 61
3028324 1986
45
Distribution and reproducibility of aryl hydrocarbon hydroxylase inducibility in a prospective population study of middle-aged male smokers and nonsmokers. 61
4027930 1985
46
Xenobiotic and endobiotic induction of mixed function monooxygenase in carp Cyprinus carpio. 61
4048925 1985
47
Comparison of aryl hydrocarbon hydroxylase and acetanilide 4-hydroxylase induction by polycyclic aromatic compounds in human and mouse cell lines. 61
2990496 1985
48
Relation between aryl hydrocarbon hydroxylase inducibility, serum gamma-glutamyltransferase and serum cholesterol in middle-aged smokers and non-smokers. 61
2859827 1985
49
Genetically mediated induction of aryl hydrocarbon hydroxylase activity in mice by polychlorinated dibenzofuran isomers and 2,3,7,8-tetrachlorodibenzo-p-dioxin. 61
3922333 1985
50
Genetically mediated induction of aryl hydrocarbon hydroxylase activity in human lymphoblastoid cells by polychlorinated dibenzofuran isomers and 2,3,7,8-tetrachlorodibenzo-p-dioxin. 61
3922334 1985

Variations for Aryl Hydrocarbon Hydroxylase Inducibility

Expression for Aryl Hydrocarbon Hydroxylase Inducibility

Search GEO for disease gene expression data for Aryl Hydrocarbon Hydroxylase Inducibility.

Pathways for Aryl Hydrocarbon Hydroxylase Inducibility

Pathways related to Aryl Hydrocarbon Hydroxylase Inducibility according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.51 CYP1A1 AHRR AHR
2
Show member pathways
12.21 CYP1A1 AHRR AHR
3 10.81 CYP1A1 AHRR AHR
4 10.55 AHRR AHR
5 10.48 CYP1A1 AHRR AHR

GO Terms for Aryl Hydrocarbon Hydroxylase Inducibility

Cellular components related to Aryl Hydrocarbon Hydroxylase Inducibility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aryl hydrocarbon receptor complex GO:0034751 8.62 AHRR AHR

Biological processes related to Aryl Hydrocarbon Hydroxylase Inducibility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 xenobiotic metabolic process GO:0006805 9.26 AHRR AHR
2 response to toxic substance GO:0009636 9.16 CYP1A1 AHR
3 intracellular receptor signaling pathway GO:0030522 8.96 AHRR AHR
4 response to xenobiotic stimulus GO:0009410 8.8 CYP1A1 AHRR AHR

Molecular functions related to Aryl Hydrocarbon Hydroxylase Inducibility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region sequence-specific DNA binding GO:0000976 9.26 AHRR AHR
2 protein dimerization activity GO:0046983 9.16 AHRR AHR
3 nuclear receptor activity GO:0004879 8.96 AHRR AHR
4 Hsp90 protein binding GO:0051879 8.62 CYP1A1 AHR

Sources for Aryl Hydrocarbon Hydroxylase Inducibility

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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