MCID: ARY002
MIFTS: 24

Aryl Hydrocarbon Hydroxylase Inducibility

Aliases & Classifications for Aryl Hydrocarbon Hydroxylase Inducibility

MalaCards integrated aliases for Aryl Hydrocarbon Hydroxylase Inducibility:

Name: Aryl Hydrocarbon Hydroxylase Inducibility 58 30 74
Ahh Inducibility 58 56
Ahh Inducibility; Ahhi 58
Ahhi 58

External Ids:

OMIM 58 108340
UMLS 74 C1862463

Summaries for Aryl Hydrocarbon Hydroxylase Inducibility

MalaCards based summary : Aryl Hydrocarbon Hydroxylase Inducibility, also known as ahh inducibility, is related to lung cancer and leukemia. An important gene associated with Aryl Hydrocarbon Hydroxylase Inducibility is CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Affiliated tissues include lung and skin.

Description from OMIM: 108340

Related Diseases for Aryl Hydrocarbon Hydroxylase Inducibility

Diseases related to Aryl Hydrocarbon Hydroxylase Inducibility via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 lung cancer 10.4
2 leukemia 10.3
3 bladder cancer 10.1
4 acute leukemia 10.1
5 bronchus cancer 10.1
6 larynx cancer 10.1
7 oropharynx cancer 10.1
8 toxic oil syndrome 9.6 AHR CYP1A1

Graphical network of the top 20 diseases related to Aryl Hydrocarbon Hydroxylase Inducibility:



Diseases related to Aryl Hydrocarbon Hydroxylase Inducibility

Symptoms & Phenotypes for Aryl Hydrocarbon Hydroxylase Inducibility

Clinical features from OMIM:

108340

Drugs & Therapeutics for Aryl Hydrocarbon Hydroxylase Inducibility

Search Clinical Trials , NIH Clinical Center for Aryl Hydrocarbon Hydroxylase Inducibility

Genetic Tests for Aryl Hydrocarbon Hydroxylase Inducibility

Genetic tests related to Aryl Hydrocarbon Hydroxylase Inducibility:

# Genetic test Affiliating Genes
1 Aryl Hydrocarbon Hydroxylase Inducibility 30

Anatomical Context for Aryl Hydrocarbon Hydroxylase Inducibility

MalaCards organs/tissues related to Aryl Hydrocarbon Hydroxylase Inducibility:

42
Lung, Skin

Publications for Aryl Hydrocarbon Hydroxylase Inducibility

Articles related to Aryl Hydrocarbon Hydroxylase Inducibility:

(show all 27)
# Title Authors Year
1
[A role of aryl hydrocarbon hydroxylase inducibility in susceptibility to lung carcinogenesis]. ( 8126925 )
1994
2
Acquisition of aryl hydrocarbon hydroxylase inducibility by aromatic hydrocarbons in monolayer-cultured hepatocytes from nonresponsive mouse strains. ( 1692256 )
1990
3
Pedigree analysis of aryl hydrocarbon hydroxylase inducibility in acute leukemia of childhood. ( 2796383 )
1989
4
Laryngeal cancer, aryl hydrocarbon hydroxylase inducibility and smoking. A follow-up study. ( 3627733 )
1987
5
Relation between aryl hydrocarbon hydroxylase inducibility, serum gamma-glutamyltransferase and serum cholesterol in middle-aged smokers and non-smokers. ( 2859827 )
1985
6
Oral and oropharyngeal cancer, aryl hydrocarbon hydroxylase inducibility and smoking. A follow-up study. ( 4000652 )
1985
7
Distribution and reproducibility of aryl hydrocarbon hydroxylase inducibility in a prospective population study of middle-aged male smokers and nonsmokers. ( 4027930 )
1985
8
Smoking, carboxyhaemoglobin, carbon monoxide in expired air and aryl hydrocarbon hydroxylase inducibility. A cross-sectional study and anti-smoking applications in middle-aged men. ( 6335015 )
1984
9
Aryl hydrocarbon hydroxylase inducibility among primary relatives of children with leukemia or solid tumors. ( 6690048 )
1984
10
Carcinoma of the oral cavity in relation to aryl hydrocarbon hydroxylase inducibility, smoking and dental status. ( 6797967 )
1981
11
Significant variation in mouse-skin aryl hydrocarbon hydroxylase inducibility as a function of the hair growth cycle. ( 7470383 )
1981
12
A twin study of aryl hydrocarbon hydroxylase (AHH) inducibility in cultured lymphocytes. ( 6944164 )
1981
13
High-pressure liquid chromatographic analysis of benzo(a)pyrene metabolism by human lymphocytes from donors of different aryl hydrocarbon hydroxylase inducibility and antipyrine half-lives. ( 7357559 )
1980
14
Aryl hydrocarbon hydroxylase inducibility is not altered in bladder cancer patients or their progeny. ( 437914 )
1979
15
Aryl hydrocarbon hydroxylase inducibility and lymphoblast formation in lung cancer patients. ( 437915 )
1979
16
Aryl hydrocarbon hydroxylase inducibility in lung cancer patients undergoing radiotherapy. ( 528067 )
1979
17
Aryl hydrocarbon hydroxylase inducibility and carcinoma of oral cavity. ( 74561 )
1978
18
Aryl-hydrocarbon-hydroxylase inducibility in patients with cancer. ( 76021 )
1978
19
Aryl hydrocarbon hydroxylase inducibility in laryngeal carcinoma. ( 629714 )
1978
20
Seasonal variation of aryl hydrocarbon hydroxylase inducibility in human lymphocytes in culture. ( 653102 )
1978
21
Aryl hydrocarbon hydroxylase inducibility and carcinoma of renal pelvis and ureter. ( 71429 )
1977
22
Distribution of aryl hydrocarbon hydroxylase inducibility in cultured human lymphocytes. ( 870187 )
1977
23
Letter: Aryl hydrocarbon hydroxylase inducibility and laryngeal carcinomas. ( 59196 )
1976
24
Editorial: Aryl hydrocarbon hydroxylase inducibility and lung cancer. ( 4133428 )
1974
25
Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma. ( 4126515 )
1973
26
Relationships between aryl hydrocarbon hydroxylase inducibility and sensitivity to chemically induced subcutaneous sarcomas in various strains of mice. ( 4702110 )
1973
27
Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice. ( 4750810 )
1973

Variations for Aryl Hydrocarbon Hydroxylase Inducibility

Expression for Aryl Hydrocarbon Hydroxylase Inducibility

Search GEO for disease gene expression data for Aryl Hydrocarbon Hydroxylase Inducibility.

Pathways for Aryl Hydrocarbon Hydroxylase Inducibility

GO Terms for Aryl Hydrocarbon Hydroxylase Inducibility

Biological processes related to Aryl Hydrocarbon Hydroxylase Inducibility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to toxic substance GO:0009636 9.16 AHR CYP1A1
2 xenobiotic metabolic process GO:0006805 8.96 AHR AHRR
3 response to xenobiotic stimulus GO:0009410 8.62 AHR AHRR

Molecular functions related to Aryl Hydrocarbon Hydroxylase Inducibility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein dimerization activity GO:0046983 8.62 AHR AHRR

Sources for Aryl Hydrocarbon Hydroxylase Inducibility

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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