AHHI
MCID: ARY002
MIFTS: 24

Aryl Hydrocarbon Hydroxylase Inducibility (AHHI)

Aliases & Classifications for Aryl Hydrocarbon Hydroxylase Inducibility

MalaCards integrated aliases for Aryl Hydrocarbon Hydroxylase Inducibility:

Name: Aryl Hydrocarbon Hydroxylase Inducibility 57 29 73
Ahh Inducibility 57 55
Ahh Inducibility; Ahhi 57
Ahhi 57

External Ids:

OMIM 57 108340
UMLS 73 C1862463

Summaries for Aryl Hydrocarbon Hydroxylase Inducibility

MalaCards based summary : Aryl Hydrocarbon Hydroxylase Inducibility, also known as ahh inducibility, is related to aging and lung cancer. An important gene associated with Aryl Hydrocarbon Hydroxylase Inducibility is CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Affiliated tissues include lung and skin.

Description from OMIM: 108340

Related Diseases for Aryl Hydrocarbon Hydroxylase Inducibility

Diseases related to Aryl Hydrocarbon Hydroxylase Inducibility via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 aging 10.2
2 lung cancer 10.2
3 leukemia 10.2
4 laryngitis 10.2
5 bladder cancer 10.0
6 acute leukemia 10.0
7 larynx cancer 10.0
8 oropharynx cancer 10.0
9 toxic oil syndrome 9.2 AHR CYP1A1

Graphical network of the top 20 diseases related to Aryl Hydrocarbon Hydroxylase Inducibility:



Diseases related to Aryl Hydrocarbon Hydroxylase Inducibility

Symptoms & Phenotypes for Aryl Hydrocarbon Hydroxylase Inducibility

Clinical features from OMIM:

108340

Drugs & Therapeutics for Aryl Hydrocarbon Hydroxylase Inducibility

Search Clinical Trials , NIH Clinical Center for Aryl Hydrocarbon Hydroxylase Inducibility

Genetic Tests for Aryl Hydrocarbon Hydroxylase Inducibility

Genetic tests related to Aryl Hydrocarbon Hydroxylase Inducibility:

# Genetic test Affiliating Genes
1 Aryl Hydrocarbon Hydroxylase Inducibility 29

Anatomical Context for Aryl Hydrocarbon Hydroxylase Inducibility

MalaCards organs/tissues related to Aryl Hydrocarbon Hydroxylase Inducibility:

41
Lung, Skin

Publications for Aryl Hydrocarbon Hydroxylase Inducibility

Articles related to Aryl Hydrocarbon Hydroxylase Inducibility:

(show all 21)
# Title Authors Year
1
[A role of aryl hydrocarbon hydroxylase inducibility in susceptibility to lung carcinogenesis]. ( 8126925 )
1994
2
Acquisition of aryl hydrocarbon hydroxylase inducibility by aromatic hydrocarbons in monolayer-cultured hepatocytes from nonresponsive mouse strains. ( 1692256 )
1990
3
Pedigree analysis of aryl hydrocarbon hydroxylase inducibility in acute leukemia of childhood. ( 2796383 )
1989
4
Laryngeal cancer, aryl hydrocarbon hydroxylase inducibility and smoking. A follow-up study. ( 3627733 )
1987
5
Distribution and reproducibility of aryl hydrocarbon hydroxylase inducibility in a prospective population study of middle-aged male smokers and nonsmokers. ( 4027930 )
1985
6
Relation between aryl hydrocarbon hydroxylase inducibility, serum gamma-glutamyltransferase and serum cholesterol in middle-aged smokers and non-smokers. ( 2859827 )
1985
7
Oral and oropharyngeal cancer, aryl hydrocarbon hydroxylase inducibility and smoking. A follow-up study. ( 4000652 )
1985
8
Aryl hydrocarbon hydroxylase inducibility among primary relatives of children with leukemia or solid tumors. ( 6690048 )
1984
9
Smoking, carboxyhaemoglobin, carbon monoxide in expired air and aryl hydrocarbon hydroxylase inducibility. A cross-sectional study and anti-smoking applications in middle-aged men. ( 6335015 )
1984
10
Carcinoma of the oral cavity in relation to aryl hydrocarbon hydroxylase inducibility, smoking and dental status. ( 6797967 )
1981
11
Significant variation in mouse-skin aryl hydrocarbon hydroxylase inducibility as a function of the hair growth cycle. ( 7470383 )
1981
12
High-pressure liquid chromatographic analysis of benzo(a)pyrene metabolism by human lymphocytes from donors of different aryl hydrocarbon hydroxylase inducibility and antipyrine half-lives. ( 7357559 )
1980
13
Aryl hydrocarbon hydroxylase inducibility and lymphoblast formation in lung cancer patients. ( 437915 )
1979
14
Aryl hydrocarbon hydroxylase inducibility is not altered in bladder cancer patients or their progeny. ( 437914 )
1979
15
Aryl hydrocarbon hydroxylase inducibility in lung cancer patients undergoing radiotherapy. ( 528067 )
1979
16
Aryl hydrocarbon hydroxylase inducibility and carcinoma of oral cavity. ( 74561 )
1978
17
Aryl hydrocarbon hydroxylase inducibility in laryngeal carcinoma. ( 629714 )
1978
18
Seasonal variation of aryl hydrocarbon hydroxylase inducibility in human lymphocytes in culture. ( 653102 )
1978
19
Aryl-hydrocarbon-hydroxylase inducibility in patients with cancer. ( 76021 )
1978
20
Distribution of aryl hydrocarbon hydroxylase inducibility in cultured human lymphocytes. ( 870187 )
1977
21
Aryl hydrocarbon hydroxylase inducibility and carcinoma of renal pelvis and ureter. ( 71429 )
1977

Variations for Aryl Hydrocarbon Hydroxylase Inducibility

Expression for Aryl Hydrocarbon Hydroxylase Inducibility

Search GEO for disease gene expression data for Aryl Hydrocarbon Hydroxylase Inducibility.

Pathways for Aryl Hydrocarbon Hydroxylase Inducibility

GO Terms for Aryl Hydrocarbon Hydroxylase Inducibility

Cellular components related to Aryl Hydrocarbon Hydroxylase Inducibility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear aryl hydrocarbon receptor complex GO:0034753 8.62 AHR AHRR

Biological processes related to Aryl Hydrocarbon Hydroxylase Inducibility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to toxic substance GO:0009636 9.16 AHR CYP1A1
2 xenobiotic metabolic process GO:0006805 8.96 AHR AHRR
3 response to xenobiotic stimulus GO:0009410 8.62 AHR AHRR

Molecular functions related to Aryl Hydrocarbon Hydroxylase Inducibility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein dimerization activity GO:0046983 8.62 AHR AHRR

Sources for Aryl Hydrocarbon Hydroxylase Inducibility

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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