MCID: ASB002
MIFTS: 26

Asbestos-Related Lung Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Asbestos-Related Lung Carcinoma

MalaCards integrated aliases for Asbestos-Related Lung Carcinoma:

Name: Asbestos-Related Lung Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:7596
NCIt 50 C27925
UMLS 73 C1332337

Summaries for Asbestos-Related Lung Carcinoma

MalaCards based summary : Asbestos-Related Lung Carcinoma is related to brain stem glioma and glioma. An important gene associated with Asbestos-Related Lung Carcinoma is PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. Affiliated tissues include lung, and related phenotypes are Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance and Decreased viability with paclitaxel

Related Diseases for Asbestos-Related Lung Carcinoma

Diseases related to Asbestos-Related Lung Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 brain stem glioma 9.6 EGFR PDGFB
2 glioma 8.9 EGFR PDGFB PRKCA
3 glioblastoma multiforme 8.1 CDC42 EGFR IGF1 PDGFB PRKCA

Symptoms & Phenotypes for Asbestos-Related Lung Carcinoma

GenomeRNAi Phenotypes related to Asbestos-Related Lung Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.55 CDC42 EGFR PIK3R3 PRKCA PRKX
2 Decreased viability with paclitaxel GR00179-A-1 9.26 EGFR IGF1
3 Decreased viability with paclitaxel GR00179-A-2 9.26 IGF1
4 Decreased viability with paclitaxel GR00179-A-3 9.26 EGFR
5 shRNA abundance <= 50% GR00343-S 9.1 EGFR IGF1 PDGFB PIK3R3 PRKCA PRKX

MGI Mouse Phenotypes related to Asbestos-Related Lung Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.35 DEGS1 EGFR IGF1 PDGFB PRKCA
2 muscle MP:0005369 9.02 DEGS1 EGFR IGF1 PDGFB PRKCA

Drugs & Therapeutics for Asbestos-Related Lung Carcinoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Early Detection of Lung Cancer and Mesothelioma in Workers Exposed to Asbestos Unknown status NCT01719068

Search NIH Clinical Center for Asbestos-Related Lung Carcinoma

Genetic Tests for Asbestos-Related Lung Carcinoma

Anatomical Context for Asbestos-Related Lung Carcinoma

MalaCards organs/tissues related to Asbestos-Related Lung Carcinoma:

41
Lung

Publications for Asbestos-Related Lung Carcinoma

Variations for Asbestos-Related Lung Carcinoma

Cosmic variations for Asbestos-Related Lung Carcinoma:

9
(show top 50) (show all 548)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6966579 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 4
2 COSM6953383 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 4
3 COSM6980872 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1142C>T p.P381L 11:102229729-102229729 4
4 COSM95548 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 4
5 COSM95544 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 4
6 COSM6980399 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.233G>A p.W78* 11:32434909-32434909 4
7 COSM6938307 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1156A>T p.K386* 11:32392044-32392044 4
8 COSM95531 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.368G>C p.G123A 5:138088927-138088927 4
9 COSM95521 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 4
10 COSM95485 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 4
11 COSM95476 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 4
12 COSM96265 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64I 17:60301699-60301699 4
13 COSM94159 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.1555A>G p.S519G 8:102326590-102326590 4
14 COSM94158 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.2691A>T p.Q897H 8:102305221-102305221 4
15 COSM6983597 U2AF1 lung,NS,carcinoma,undifferentiated carcinoma c.319G>C p.D107H 21:43095467-43095467 4
16 COSM95420 TYK2 lung,NS,carcinoma,undifferentiated carcinoma c.3560G>T p.C1187F 19:10350838-10350838 4
17 COSM6942934 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.1922C>T p.S641L 14:81143980-81143980 4
18 COSM6953382 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.937A>C p.K313Q 14:81142995-81142995 4
19 COSM6966576 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.412C>T p.L138F 14:81091088-81091088 4
20 COSM6980873 TSC2 lung,NS,carcinoma,undifferentiated carcinoma c.1840G>T p.A614S 16:2071510-2071510 4
21 COSM6980394 TSC1 lung,NS,carcinoma,undifferentiated carcinoma c.694G>T p.E232* 9:132921406-132921406 4
22 COSM6980408 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1193C>T p.P398L 16:2173978-2173978 4
23 COSM6940747 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1287C>G p.Y429* 16:2174274-2174274 4
24 COSM95390 TRAF5 lung,NS,carcinoma,undifferentiated carcinoma c.302G>C p.R101T 1:211356392-211356392 4
25 COSM22908 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.376-1G>T p.? 17:7675237-7675237 4
26 COSM11232 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.842A>G p.D281G 17:7673778-7673778 4
27 COSM45304 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.375+1G>A p.? 17:7675993-7675993 4
28 COSM10768 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.535C>T p.H179Y 17:7675077-7675077 4
29 COSM10742 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.578A>G p.H193R 17:7674953-7674953 4
30 COSM11333 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.499C>T p.Q167* 17:7675113-7675113 4
31 COSM10779 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>T p.R273L 17:7673802-7673802 4
32 COSM11354 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.991C>T p.Q331* 17:7673537-7673537 4
33 COSM11073 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.1024C>T p.R342* 17:7670685-7670685 4
34 COSM6815 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.461G>T p.G154V 17:7675151-7675151 4
35 COSM43750 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.811G>T p.E271* 17:7673809-7673809 4
36 COSM6913 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.783-1G>T p.? 17:7673838-7673838 4
37 COSM10645 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.527G>T p.C176F 17:7675085-7675085 4
38 COSM44295 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.993+1G>A p.? 17:7673534-7673534 4
39 COSM13584 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.919+1G>T p.? 17:7673700-7673700 4
40 COSM10660 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>A p.R273H 17:7673802-7673802 4
41 COSM43753 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.560-1G>A p.? 17:7674972-7674972 4
42 COSM44240 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.514G>T p.V172F 17:7675098-7675098 4
43 COSM44891 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.796G>T p.G266* 17:7673824-7673824 4
44 COSM10889 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.536A>G p.H179R 17:7675076-7675076 4
45 COSM10714 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.473G>T p.R158L 17:7675139-7675139 4
46 COSM95367 TLR5 lung,NS,carcinoma,undifferentiated carcinoma c.1A>G p.M1V 1:223113031-223113031 4
47 COSM95359 TLR4 lung,NS,carcinoma,undifferentiated carcinoma c.337C>A p.P113T 9:117712465-117712465 4
48 COSM95356 TLR2 lung,NS,carcinoma,undifferentiated carcinoma c.1169A>G p.Q390R 4:153704076-153704076 4
49 COSM95347 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.1087C>T p.P363S 9:35721665-35721665 4
50 COSM95342 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.5624C>T p.S1875L 9:35705660-35705660 4

Expression for Asbestos-Related Lung Carcinoma

Search GEO for disease gene expression data for Asbestos-Related Lung Carcinoma.

Pathways for Asbestos-Related Lung Carcinoma

Pathways related to Asbestos-Related Lung Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
2
Show member pathways
13.68 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
3
Show member pathways
13.54 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
4
Show member pathways
13.4 EGFR IGF1 PDGFB PIK3R3 PRKCA
5
Show member pathways
13.36 CDC42 EGFR IGF1 PDGFB PIK3R3
6
Show member pathways
13.35 CDC42 EGFR PDGFB PIK3R3 PRKCA
7
Show member pathways
13.26 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
8
Show member pathways
13.19 EGFR IGF1 PDGFB PIK3R3 PRKCA
9
Show member pathways
13.18 CDC42 IGF1 PDGFB PIK3R3 PRKCA
10
Show member pathways
13.14 EGFR IGF1 PDGFB PIK3R3 PRKCA
11
Show member pathways
13.13 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
12
Show member pathways
12.95 CDC42 EGFR PDGFB PRKCA
13
Show member pathways
12.93 EGFR IGF1 PDGFB PIK3R3 PRKCA
14
Show member pathways
12.9 CDC42 EGFR PIK3R3 PRKCA
15
Show member pathways
12.88 CDC42 IGF1 PIK3R3 PRKCA
16
Show member pathways
12.84 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
17
Show member pathways
12.8 CDC42 PDGFB PIK3R3 PRKCA
18
Show member pathways
12.79 CDC42 EGFR IGF1 PIK3R3
19
Show member pathways
12.74 CDC42 EGFR IGF1 PIK3R3 PRKCA
20
Show member pathways
12.74 CDC42 EGFR IGF1 PDGFB PIK3R3
21
Show member pathways
12.74 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
22
Show member pathways
12.66 EGFR IGF1 PIK3R3 PRKCA
23
Show member pathways
12.64 CDC42 EGFR IGF1 PIK3R3 PRKCA
24
Show member pathways
12.63 EGFR IGF1 PDGFB PIK3R3 PRKCA
25 12.62 CDC42 EGFR IGF1 PDGFB PRKCA
26
Show member pathways
12.61 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
27
Show member pathways
12.57 EGFR PDGFB PIK3R3 PRKCA
28
Show member pathways
12.54 EGFR IGF1 PDGFB PIK3R3 PRKCA
29
Show member pathways
12.53 EGFR PDGFB PIK3R3
30 12.53 CDC42 EGFR PDGFB PIK3R3
31
Show member pathways
12.52 CDC42 EGFR IGF1 PIK3R3 PRKCA
32 12.52 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
33
Show member pathways
12.47 EGFR PDGFB PIK3R3
34
Show member pathways
12.47 CDC42 PIK3R3 PRKCA
35
Show member pathways
12.47 CDC42 EGFR IGF1 PIK3R3
36
Show member pathways
12.46 PDGFB PIK3R3 PRKCA
37
Show member pathways
12.43 CDC42 EGFR PRKCA
38
Show member pathways
12.42 EGFR PIK3R3 PRKCA
39
Show member pathways
12.41 CDC42 PIK3R3 PRKCA
40
Show member pathways
12.41 EGFR IGF1 PIK3R3 PRKCA
41 12.4 EGFR PDGFB PRKCA
42
Show member pathways
12.36 CDC42 EGFR PRKCA
43
Show member pathways
12.36 PDGFB PIK3R3 PRKCA
44
Show member pathways
12.34 CDC42 PIK3R3 PRKCA
45
Show member pathways
12.34 EGFR PIK3R3 PRKCA
46
Show member pathways
12.32 EGFR PDGFB PIK3R3 PRKCA
47
Show member pathways
12.31 EGFR PIK3R3 PRKCA
48
Show member pathways
12.31 CDC42 EGFR PIK3R3 PRKCA
49
Show member pathways
12.29 CDC42 PIK3R3 PRKCA
50
Show member pathways
12.28 CDC42 PIK3R3 PRKCA

GO Terms for Asbestos-Related Lung Carcinoma

Biological processes related to Asbestos-Related Lung Carcinoma according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.72 EGFR PDGFB PRKCA
2 protein phosphorylation GO:0006468 9.65 CDC42 EGFR PDGFB PRKCA PRKX
3 peptidyl-serine phosphorylation GO:0018105 9.63 PDGFB PRKCA PRKX
4 cellular response to growth factor stimulus GO:0071363 9.59 EGFR PDGFB
5 positive regulation of blood vessel endothelial cell migration GO:0043536 9.58 PDGFB PRKCA
6 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.58 IGF1 PDGFB
7 positive regulation of MAPK cascade GO:0043410 9.58 EGFR IGF1 PDGFB
8 ERBB2 signaling pathway GO:0038128 9.57 EGFR PRKCA
9 activation of protein kinase B activity GO:0032148 9.56 IGF1 PDGFB
10 negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 9.54 CDC42 EGFR
11 phosphatidylinositol phosphorylation GO:0046854 9.54 EGFR PDGFB PIK3R3
12 positive regulation of mitotic nuclear division GO:0045840 9.52 IGF1 PDGFB
13 embryonic placenta development GO:0001892 9.51 EGFR PDGFB
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.5 EGFR IGF1 PDGFB
15 positive regulation of cardiac muscle hypertrophy GO:0010613 9.49 IGF1 PRKCA
16 positive regulation of smooth muscle cell migration GO:0014911 9.48 IGF1 PDGFB
17 positive regulation of bone resorption GO:0045780 9.43 EGFR PRKCA
18 positive regulation of fibroblast proliferation GO:0048146 9.33 EGFR IGF1 PDGFB
19 positive regulation of cell migration GO:0030335 9.26 EGFR IGF1 PDGFB PRKCA
20 positive regulation of DNA replication GO:0045740 8.8 EGFR IGF1 PDGFB

Molecular functions related to Asbestos-Related Lung Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 8.8 EGFR IGF1 PRKCA

Sources for Asbestos-Related Lung Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....