MCID: ASB002
MIFTS: 27

Asbestos-Related Lung Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Asbestos-Related Lung Carcinoma

MalaCards integrated aliases for Asbestos-Related Lung Carcinoma:

Name: Asbestos-Related Lung Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:7596
NCIt 51 C27925
UMLS 74 C1332337

Summaries for Asbestos-Related Lung Carcinoma

MalaCards based summary : Asbestos-Related Lung Carcinoma is related to brain stem glioma and glioblastoma. An important gene associated with Asbestos-Related Lung Carcinoma is PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. Affiliated tissues include lung and brain, and related phenotypes are Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance and Decreased viability with paclitaxel

Related Diseases for Asbestos-Related Lung Carcinoma

Diseases related to Asbestos-Related Lung Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 brain stem glioma 9.5 EGFR PDGFB
2 glioblastoma 9.5 EGFR PDGFB PRKCA
3 glioma 9.4 EGFR PDGFB PRKCA
4 glioblastoma multiforme 8.8 CDC42 EGFR IGF1 PDGFB PRKCA

Symptoms & Phenotypes for Asbestos-Related Lung Carcinoma

GenomeRNAi Phenotypes related to Asbestos-Related Lung Carcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.65 CDC42 EGFR PIK3R3 PRKCA PRKX
2 Decreased viability with paclitaxel GR00179-A-1 9.46 EGFR IGF1
3 Decreased viability with paclitaxel GR00179-A-2 9.46 IGF1
4 Decreased viability with paclitaxel GR00179-A-3 9.46 EGFR
5 shRNA abundance <= 50% GR00343-S 9.1 EGFR IGF1 PDGFB PIK3R3 PRKCA PRKX
6 Increased senescence-associated beta-galactosidase protein expression after pRB stimulation GR00230-A-2 8.96 PRKCA PRKX

Drugs & Therapeutics for Asbestos-Related Lung Carcinoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Early Detection of Lung Cancer and Mesothelioma in Workers Exposed to Asbestos Unknown status NCT01719068

Search NIH Clinical Center for Asbestos-Related Lung Carcinoma

Genetic Tests for Asbestos-Related Lung Carcinoma

Anatomical Context for Asbestos-Related Lung Carcinoma

MalaCards organs/tissues related to Asbestos-Related Lung Carcinoma:

42
Lung, Brain

Publications for Asbestos-Related Lung Carcinoma

Variations for Asbestos-Related Lung Carcinoma

Cosmic variations for Asbestos-Related Lung Carcinoma:

9 (show top 50) (show all 548)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6953383 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 0
2 COSM6966579 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 0
3 COSM6980872 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1142C>T p.P381L 11:102229729-102229729 0
4 COSM95548 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 0
5 COSM95544 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 0
6 COSM6980399 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.233G>A p.W78* 11:32434909-32434909 0
7 COSM6938307 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1156A>T p.K386* 11:32392044-32392044 0
8 COSM95531 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.368G>C p.G123A 5:138088927-138088927 0
9 COSM95521 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 0
10 COSM95485 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 0
11 COSM95476 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 0
12 COSM96265 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64I 17:60301699-60301699 0
13 COSM94159 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.1555A>G p.S519G 8:102326590-102326590 0
14 COSM94158 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.2691A>T p.Q897H 8:102305221-102305221 0
15 COSM6983597 U2AF1 lung,NS,carcinoma,undifferentiated carcinoma c.319G>C p.D107H 21:43095467-43095467 0
16 COSM95420 TYK2 lung,NS,carcinoma,undifferentiated carcinoma c.3560G>T p.C1187F 19:10350838-10350838 0
17 COSM6942934 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.1922C>T p.S641L 14:81143980-81143980 0
18 COSM6953382 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.937A>C p.K313Q 14:81142995-81142995 0
19 COSM6966576 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.412C>T p.L138F 14:81091088-81091088 0
20 COSM6980873 TSC2 lung,NS,carcinoma,undifferentiated carcinoma c.1840G>T p.A614S 16:2071510-2071510 0
21 COSM6980394 TSC1 lung,NS,carcinoma,undifferentiated carcinoma c.694G>T p.E232* 9:132921406-132921406 0
22 COSM6980408 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1193C>T p.P398L 16:2173978-2173978 0
23 COSM6940747 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1287C>G p.Y429* 16:2174274-2174274 0
24 COSM95390 TRAF5 lung,NS,carcinoma,undifferentiated carcinoma c.302G>C p.R101T 1:211356392-211356392 0
25 COSM22908 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.376-1G>T p.? 17:7675237-7675237 0
26 COSM11232 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.842A>G p.D281G 17:7673778-7673778 0
27 COSM45304 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.375+1G>A p.? 17:7675993-7675993 0
28 COSM10768 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.535C>T p.H179Y 17:7675077-7675077 0
29 COSM10742 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.578A>G p.H193R 17:7674953-7674953 0
30 COSM11333 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.499C>T p.Q167* 17:7675113-7675113 0
31 COSM10779 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>T p.R273L 17:7673802-7673802 0
32 COSM11354 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.991C>T p.Q331* 17:7673537-7673537 0
33 COSM11073 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.1024C>T p.R342* 17:7670685-7670685 0
34 COSM6815 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.461G>T p.G154V 17:7675151-7675151 0
35 COSM43750 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.811G>T p.E271* 17:7673809-7673809 0
36 COSM6913 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.783-1G>T p.? 17:7673838-7673838 0
37 COSM10645 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.527G>T p.C176F 17:7675085-7675085 0
38 COSM44295 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.993+1G>A p.? 17:7673534-7673534 0
39 COSM13584 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.919+1G>T p.? 17:7673700-7673700 0
40 COSM10660 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>A p.R273H 17:7673802-7673802 0
41 COSM43753 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.560-1G>A p.? 17:7674972-7674972 0
42 COSM44240 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.514G>T p.V172F 17:7675098-7675098 0
43 COSM44891 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.796G>T p.G266* 17:7673824-7673824 0
44 COSM10889 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.536A>G p.H179R 17:7675076-7675076 0
45 COSM10714 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.473G>T p.R158L 17:7675139-7675139 0
46 COSM95367 TLR5 lung,NS,carcinoma,undifferentiated carcinoma c.1A>G p.M1V 1:223113031-223113031 0
47 COSM95359 TLR4 lung,NS,carcinoma,undifferentiated carcinoma c.337C>A p.P113T 9:117712465-117712465 0
48 COSM95356 TLR2 lung,NS,carcinoma,undifferentiated carcinoma c.1169A>G p.Q390R 4:153704076-153704076 0
49 COSM95347 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.1087C>T p.P363S 9:35721665-35721665 0
50 COSM95342 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.5624C>T p.S1875L 9:35705660-35705660 0

Expression for Asbestos-Related Lung Carcinoma

Search GEO for disease gene expression data for Asbestos-Related Lung Carcinoma.

Pathways for Asbestos-Related Lung Carcinoma

Pathways related to Asbestos-Related Lung Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
2
Show member pathways
13.68 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
3
Show member pathways
13.51 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
4
Show member pathways
13.4 EGFR IGF1 PDGFB PIK3R3 PRKCA
5
Show member pathways
13.37 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
6
Show member pathways
13.35 CDC42 EGFR PDGFB PIK3R3 PRKCA
7
Show member pathways
13.26 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
8
Show member pathways
13.19 EGFR IGF1 PDGFB PIK3R3 PRKCA
9
Show member pathways
13.18 CDC42 IGF1 PDGFB PIK3R3 PRKCA
10
Show member pathways
13.14 EGFR IGF1 PDGFB PIK3R3 PRKCA
11
Show member pathways
13.13 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
12
Show member pathways
13.08 CDC42 EGFR IGF1 PIK3R3 PRKCA
13
Show member pathways
12.96 CDC42 EGFR PDGFB PRKCA
14
Show member pathways
12.93 EGFR IGF1 PDGFB PIK3R3 PRKCA
15
Show member pathways
12.91 CDC42 EGFR PIK3R3 PRKCA
16
Show member pathways
12.89 CDC42 IGF1 PIK3R3 PRKCA
17
Show member pathways
12.85 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
18
Show member pathways
12.84 EGFR PDGFB PIK3R3 PRKCA
19
Show member pathways
12.83 CDC42 EGFR IGF1 PIK3R3
20
Show member pathways
12.81 CDC42 PDGFB PIK3R3 PRKCA
21
Show member pathways
12.8 CDC42 EGFR IGF1 PIK3R3
22
Show member pathways
12.75 CDC42 EGFR IGF1 PIK3R3 PRKCA
23
Show member pathways
12.75 CDC42 EGFR IGF1 PDGFB PIK3R3
24
Show member pathways
12.75 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
25
Show member pathways
12.67 EGFR IGF1 PIK3R3 PRKCA
26 12.62 CDC42 EGFR IGF1 PDGFB PRKCA
27
Show member pathways
12.61 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
28
Show member pathways
12.59 EGFR PDGFB PIK3R3 PRKCA
29
Show member pathways
12.56 EGFR IGF1 PDGFB PIK3R3 PRKCA
30
Show member pathways
12.55 EGFR PIK3R3 PRKCA
31 12.54 CDC42 EGFR PDGFB PIK3R3
32
Show member pathways
12.54 EGFR IGF1 PDGFB PIK3R3 PRKCA
33
Show member pathways
12.53 CDC42 PIK3R3 PRKCA
34
Show member pathways
12.52 CDC42 EGFR IGF1 PIK3R3 PRKCA
35
Show member pathways
12.48 EGFR PDGFB PIK3R3
36
Show member pathways
12.48 CDC42 PIK3R3 PRKCA
37
Show member pathways
12.48 CDC42 EGFR IGF1 PIK3R3
38 12.46 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
39
Show member pathways
12.43 EGFR PIK3R3 PRKCA
40
Show member pathways
12.43 CDC42 EGFR PRKCA
41
Show member pathways
12.42 EGFR IGF1 PIK3R3 PRKCA
42
Show member pathways
12.41 CDC42 PIK3R3 PRKCA
43 12.41 EGFR PDGFB PRKCA
44
Show member pathways
12.41 CDC42 EGFR PDGFB PIK3R3 PRKCA
45
Show member pathways
12.38 CDC42 EGFR PRKCA
46
Show member pathways
12.38 PDGFB PIK3R3 PRKCA
47
Show member pathways
12.35 CDC42 PIK3R3 PRKCA
48
Show member pathways
12.35 EGFR PIK3R3 PRKCA
49
Show member pathways
12.33 EGFR PDGFB PIK3R3 PRKCA
50
Show member pathways
12.32 CDC42 EGFR PIK3R3 PRKCA

GO Terms for Asbestos-Related Lung Carcinoma

Cellular components related to Asbestos-Related Lung Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.62 IGF1 PDGFB

Biological processes related to Asbestos-Related Lung Carcinoma according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.73 EGFR PDGFB PRKCA
2 positive regulation of epithelial cell proliferation GO:0050679 9.61 EGFR IGF1
3 positive regulation of MAP kinase activity GO:0043406 9.61 EGFR PDGFB
4 cellular response to growth factor stimulus GO:0071363 9.6 EGFR PDGFB
5 positive regulation of blood vessel endothelial cell migration GO:0043536 9.59 PDGFB PRKCA
6 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.58 IGF1 PDGFB
7 protein kinase B signaling GO:0043491 9.58 IGF1 PIK3R3
8 peptidyl-serine phosphorylation GO:0018105 9.58 PDGFB PRKCA PRKX
9 activation of protein kinase B activity GO:0032148 9.57 IGF1 PDGFB
10 ERBB2 signaling pathway GO:0038128 9.55 EGFR PRKCA
11 negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 9.54 CDC42 EGFR
12 positive regulation of DNA replication GO:0045740 9.52 CDC42 EGFR
13 positive regulation of mitotic nuclear division GO:0045840 9.51 IGF1 PDGFB
14 positive regulation of cardiac muscle hypertrophy GO:0010613 9.49 IGF1 PRKCA
15 embryonic placenta development GO:0001892 9.48 EGFR PDGFB
16 positive regulation of smooth muscle cell migration GO:0014911 9.46 IGF1 PDGFB
17 positive regulation of bone resorption GO:0045780 9.43 EGFR PRKCA
18 positive regulation of smooth muscle cell proliferation GO:0048661 9.43 EGFR IGF1 PDGFB
19 positive regulation of MAPK cascade GO:0043410 9.37 IGF1 PDGFB
20 positive regulation of fibroblast proliferation GO:0048146 9.33 EGFR IGF1 PDGFB
21 protein phosphorylation GO:0006468 9.26 EGFR PDGFB PRKCA PRKX
22 phosphatidylinositol phosphorylation GO:0046854 9.02 PIK3R3
23 positive regulation of cell migration GO:0030335 9.02 EGFR IGF1 PDGFB PIK3R3 PRKCA

Molecular functions related to Asbestos-Related Lung Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 8.8 EGFR IGF1 PRKCA

Sources for Asbestos-Related Lung Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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