MCID: ASB002
MIFTS: 32

Asbestos-Related Lung Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Asbestos-Related Lung Carcinoma

MalaCards integrated aliases for Asbestos-Related Lung Carcinoma:

Name: Asbestos-Related Lung Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:7596
NCIt 49 C27925
UMLS 71 C1332337

Summaries for Asbestos-Related Lung Carcinoma

MalaCards based summary : Asbestos-Related Lung Carcinoma is related to exencephaly and retinal detachment. An important gene associated with Asbestos-Related Lung Carcinoma is ANKRD20A3P (Ankyrin Repeat Domain 20 Family Member A3, Pseudogene), and among its related pathways/superpathways are GPCR Pathway and TGF-Beta Pathway. Affiliated tissues include lung, and related phenotypes are Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance and Decreased viability with paclitaxel

Related Diseases for Asbestos-Related Lung Carcinoma

Diseases related to Asbestos-Related Lung Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 exencephaly 9.8 TXNRD1 TXN
2 retinal detachment 9.3 PDGFB PDGFA IGF1
3 wilms tumor 1 8.8 PRKCA PDGFA IGF1 EGFR
4 glioblastoma multiforme 8.3 PRKCA PIK3R3 PDGFB PDGFA IGF1 EGFR

Symptoms & Phenotypes for Asbestos-Related Lung Carcinoma

GenomeRNAi Phenotypes related to Asbestos-Related Lung Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.43 CDC42 EGFR IKBKB PIK3R3 PRKCA PRKX
2 Decreased viability with paclitaxel GR00179-A-1 9.02 EGFR IGF1 IKBKB
3 Decreased viability with paclitaxel GR00179-A-2 9.02 IGF1
4 Decreased viability with paclitaxel GR00179-A-3 9.02 EGFR

MGI Mouse Phenotypes related to Asbestos-Related Lung Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.17 ABHD12 EGFR IGF1 IKBKB PDGFA PDGFB

Drugs & Therapeutics for Asbestos-Related Lung Carcinoma

Search Clinical Trials , NIH Clinical Center for Asbestos-Related Lung Carcinoma

Genetic Tests for Asbestos-Related Lung Carcinoma

Anatomical Context for Asbestos-Related Lung Carcinoma

MalaCards organs/tissues related to Asbestos-Related Lung Carcinoma:

40
Lung

Publications for Asbestos-Related Lung Carcinoma

Articles related to Asbestos-Related Lung Carcinoma:

# Title Authors PMID Year
1
Pathway deviation-based biomarker and multi-effect target identification in asbestos-related squamous cell carcinoma of the lung. 61
28204826 2017
2
Asbestos-related disease. 61
11933817 2002

Variations for Asbestos-Related Lung Carcinoma

Cosmic variations for Asbestos-Related Lung Carcinoma:

9 (show top 50) (show all 1540)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM149314749 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 6
2 COSM149318860 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 6
3 COSM143041512 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1316C>T p.P439L 11:102229729-102229729 6
4 COSM97230831 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 6
5 COSM85312404 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 6
6 COSM91372655 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.437G>A p.W146* 11:32434909-32434909 6
7 COSM91383011 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1360A>T p.K454* 11:32392044-32392044 6
8 COSM124478343 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.422G>C p.G141A 5:138088927-138088927 6
9 COSM87652733 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 6
10 COSM84601598 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 6
11 COSM88410243 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 6
12 COSM87541563 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64= 17:60301699-60301699 6
13 COSM145430147 UHRF1 lung,NS,carcinoma,undifferentiated carcinoma c.1467C>G p.F489L 19:4947122-4947122 6
14 COSM127070824 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.2691A>T p.Q897H 8:102305221-102305221 6
15 COSM127059821 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.1555A>G p.S519G 8:102326590-102326590 6
16 COSM85195038 U2AF1 lung,NS,carcinoma,undifferentiated carcinoma c.319G>C p.D107H 21:43095467-43095467 6
17 COSM130300868 TYK2 lung,NS,carcinoma,undifferentiated carcinoma c.3560G>T p.C1187F 19:10350838-10350838 6
18 COSM131090496 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.1922C>T p.S641L 14:81143980-81143980 6
19 COSM131094722 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.412C>T p.L138F 14:81091088-81091088 6
20 COSM131094002 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.937A>C p.K313Q 14:81142995-81142995 6
21 COSM87049256 TSC2 lung,NS,carcinoma,undifferentiated carcinoma c.1840G>T p.A614S 16:2071510-2071510 6
22 COSM85721789 TSC1 lung,NS,carcinoma,undifferentiated carcinoma c.694G>T p.E232* 9:132921406-132921406 6
23 COSM90140992 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1193C>T p.P398L 16:2173978-2173978 6
24 COSM90145840 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1287C>G p.Y429* 16:2174274-2174274 6
25 COSM87090089 TRAF5 lung,NS,carcinoma,undifferentiated carcinoma c.302G>C p.R101T 1:211356392-211356392 6
26 COSM87898991 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.535C>T p.H179Y 17:7675077-7675077 6
27 COSM87901497 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.461G>T p.G154V 17:7675151-7675151 6
28 COSM87935416 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.499C>T p.Q167* 17:7675113-7675113 6
29 COSM87904420 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.514G>T p.V172F 17:7675098-7675098 6
30 COSM87898444 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.536A>G p.H179R 17:7675076-7675076 6
31 COSM87906107 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.473G>T p.R158L 17:7675139-7675139 6
32 COSM87909792 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.919+1G>T p.? 17:7673700-7673700 6
33 COSM87940740 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.811G>T p.E271* 17:7673809-7673809 6
34 COSM87899785 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.991C>T p.Q331* 17:7673537-7673537 6
35 COSM87902162 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.783-1G>T p.? 17:7673838-7673838 6
36 COSM87915599 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.842A>G p.D281G 17:7673778-7673778 6
37 COSM87897914 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.527G>T p.C176F 17:7675085-7675085 6
38 COSM87899377 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.375+1G>A p.? 17:7675993-7675993 6
39 COSM87900565 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.1024C>T p.R342* 17:7670685-7670685 6
40 COSM87918616 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.993+1G>A p.? 17:7673534-7673534 6
41 COSM87897711 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>A p.R273H 17:7673802-7673802 6
42 COSM87900157 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>T p.R273L 17:7673802-7673802 6
43 COSM87942817 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.376-1G>T p.? 17:7675237-7675237 6
44 COSM87903076 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.796G>T p.G266* 17:7673824-7673824 6
45 COSM87898836 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.560-1G>A p.? 17:7674972-7674972 6
46 COSM87898881 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.578A>G p.H193R 17:7674953-7674953 6
47 COSM150205149 TLR4 lung,NS,carcinoma,undifferentiated carcinoma c.337C>A p.P113T 9:117712465-117712465 6
48 COSM85378871 TLR2 lung,NS,carcinoma,undifferentiated carcinoma c.1169A>G p.Q390R 4:153704076-153704076 6
49 COSM90180942 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.5624C>T p.S1875L 9:35705660-35705660 6
50 COSM90180404 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.1087C>T p.P363S 9:35721665-35721665 6

Expression for Asbestos-Related Lung Carcinoma

Search GEO for disease gene expression data for Asbestos-Related Lung Carcinoma.

Pathways for Asbestos-Related Lung Carcinoma

Pathways related to Asbestos-Related Lung Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 PRKX PRKCA PIK3R3 PDGFB PDGFA IKBKB
2
Show member pathways
13.56 PRKCA PIK3R3 PDGFB PDGFA IKBKB IGF1
3
Show member pathways
13.43 PRKCA PIK3R3 PDGFB PDGFA IKBKB IGF1
4
Show member pathways
13.34 PRKCA PIK3R3 PDGFB PDGFA IGF1 CDC42
5
Show member pathways
13.2 TXNRD1 PRKCA PIK3R3 PDGFB PDGFA IKBKB
6
Show member pathways
13.07 PRKCA PIK3R3 PDGFB PDGFA IGF1 EGFR
7
Show member pathways
13.03 PRKCA PIK3R3 PDGFB PDGFA IKBKB IGF1
8
Show member pathways
12.99 PRKCA PIK3R3 IKBKB IGF1 CDC42
9
Show member pathways
12.97 TXN PIK3R3 NFKB2 IKBKB IGF1 EGFR
10
Show member pathways
12.95 PRKCA PIK3R3 PDGFB PDGFA IKBKB CDC42
11
Show member pathways
12.94 PRKCA PIK3R3 PDGFB IKBKB EGFR
12
Show member pathways
12.91 PIK3R3 IKBKB IGF1 EGFR CDC42
13
Show member pathways
12.89 PRKCA PIK3R3 IKBKB IGF1 EGFR CDC42
14
Show member pathways
12.87 PRKCA PIK3R3 PDGFB PDGFA IKBKB IGF1
15
Show member pathways
12.85 PRKCA PIK3R3 PDGFB PDGFA IGF1 EGFR
16
Show member pathways
12.81 PIK3R3 PDGFB PDGFA IKBKB IGF1 EGFR
17
Show member pathways
12.75 PIK3R3 PDGFB PDGFA IKBKB EGFR
18
Show member pathways
12.75 TXNRD1 PRKCA PIK3R3 NFKB2 IGF1 EGFR
19
Show member pathways
12.67 PRKCA PIK3R3 IGF1 EGFR CDC42
20 12.66 PIK3R3 PDGFB PDGFA EGFR CDC42
21
Show member pathways
12.65 PRKCA PIK3R3 PDGFB PDGFA IGF1 EGFR
22
Show member pathways
12.64 PRKCA PIK3R3 PDGFB PDGFA IKBKB EGFR
23 12.64 PRKCA PDGFB PDGFA NFKB2 IKBKB IGF1
24
Show member pathways
12.61 PRKCA PIK3R3 NFKB2 IKBKB CDC42
25
Show member pathways
12.57 PIK3R3 IGF1 EGFR CDC42
26
Show member pathways
12.57 PRKCA PIK3R3 PDGFB PDGFA IKBKB IGF1
27
Show member pathways
12.56 PIK3R3 PDGFB PDGFA NFKB2 IKBKB EGFR
28
Show member pathways
12.53 PRKCA PIK3R3 IKBKB IGF1 EGFR
29
Show member pathways
12.52 PRKCA PIK3R3 NFKB2 IKBKB EGFR
30
Show member pathways
12.49 PRKCA IKBKB EGFR CDC42
31
Show member pathways
12.48 PRKCA PIK3R3 PDGFB PDGFA
32 12.48 PRKCA PIK3R3 PDGFB PDGFA IKBKB EGFR
33
Show member pathways
12.48 PRKCA PIK3R3 PDGFB PDGFA NFKB2 IKBKB
34
Show member pathways
12.47 PRKCA PIK3R3 NFKB2 IKBKB EGFR
35
Show member pathways
12.43 PIK3R3 NFKB2 IKBKB CDC42
36
Show member pathways
12.42 PRKCA PIK3R3 IKBKB EGFR
37
Show member pathways
12.42 PRKCA PIK3R3 PDGFB PDGFA EGFR
38
Show member pathways
12.41 PRKCA PIK3R3 EGFR CDC42
39
Show member pathways
12.41 PIK3R3 NFKB2 IKBKB IGF1
40
Show member pathways
12.41 PIK3R3 PDGFB PDGFA IGF1 EGFR CDC42
41
Show member pathways
12.4 PRKCA PIK3R3 IKBKB CDC42
42
Show member pathways
12.4 PRKCA PIK3R3 NFKB2 IKBKB CDC42
43 12.39 PIK3R3 IKBKB EGFR CDC42
44
Show member pathways
12.37 PIK3R3 PDGFB PDGFA EGFR
45
Show member pathways
12.34 PRKCA PIK3R3 IGF1 EGFR
46
Show member pathways
12.29 PRKCA PDGFB PDGFA IGF1 EGFR
47 12.29 PRKCA PIK3R3 IGF1 EGFR CDC42
48
Show member pathways
12.2 PRKCA PIK3R3 IKBKB IGF1
49
Show member pathways
12.11 PIK3R3 IKBKB IGF1 EGFR
50
Show member pathways
12.11 PRKCA PIK3R3 PDGFB PDGFA NFKB2 IGF1

GO Terms for Asbestos-Related Lung Carcinoma

Cellular components related to Asbestos-Related Lung Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.8 PDGFB PDGFA IGF1

Biological processes related to Asbestos-Related Lung Carcinoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 protein phosphorylation GO:0006468 9.96 PRKX PRKCA PDGFB IKBKB EGFR
2 negative regulation of apoptotic process GO:0043066 9.95 IKBKB IGF1 EGFR BNIP3L API5
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.8 PRKCA PDGFB PDGFA EGFR
4 positive regulation of protein kinase B signaling GO:0051897 9.73 TXN PDGFB PDGFA EGFR
5 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.71 PDGFB PDGFA IGF1
6 peptidyl-serine phosphorylation GO:0018105 9.71 PRKX PRKCA PDGFB IKBKB
7 positive regulation of MAP kinase activity GO:0043406 9.65 PDGFB PDGFA EGFR
8 positive regulation of smooth muscle cell proliferation GO:0048661 9.63 PDGFB IGF1 EGFR
9 positive regulation of smooth muscle cell migration GO:0014911 9.57 PDGFB IGF1
10 positive regulation of MAPK cascade GO:0043410 9.56 PDGFB PDGFA IGF1 CDC42
11 cell activation GO:0001775 9.52 PDGFA IGF1
12 negative regulation of platelet activation GO:0010544 9.51 PDGFB PDGFA
13 activation of protein kinase B activity GO:0032148 9.5 TXN PDGFB IGF1
14 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway GO:0035793 9.37 PDGFB PDGFA
15 positive regulation of fibroblast proliferation GO:0048146 9.26 PDGFB PDGFA IGF1 EGFR
16 negative regulation of phosphatidylinositol biosynthetic process GO:0010512 9.16 PDGFB PDGFA
17 positive regulation of cell migration GO:0030335 9.1 PRKCA PIK3R3 PDGFB PDGFA IGF1 EGFR

Molecular functions related to Asbestos-Related Lung Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.35 PDGFB PDGFA IKBKB EGFR BNIP3L
2 platelet-derived growth factor receptor binding GO:0005161 9.26 PDGFB PDGFA
3 platelet-derived growth factor binding GO:0048407 9.16 PDGFB PDGFA
4 thioredoxin-disulfide reductase activity GO:0004791 8.62 TXNRD1 TXN

Sources for Asbestos-Related Lung Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....