MCID: ASB002
MIFTS: 32

Asbestos-Related Lung Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Asbestos-Related Lung Carcinoma

MalaCards integrated aliases for Asbestos-Related Lung Carcinoma:

Name: Asbestos-Related Lung Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:7596
NCIt 50 C27925
UMLS 72 C1332337

Summaries for Asbestos-Related Lung Carcinoma

MalaCards based summary : Asbestos-Related Lung Carcinoma is related to brain stem glioma and glioblastoma. An important gene associated with Asbestos-Related Lung Carcinoma is PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. Affiliated tissues include lung, and related phenotypes are Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance and Decreased viability with paclitaxel

Related Diseases for Asbestos-Related Lung Carcinoma

Diseases related to Asbestos-Related Lung Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 brain stem glioma 9.3 PDGFB EGFR
2 glioblastoma 9.1 PRKCA PDGFB EGFR
3 glioma 9.1 PRKCA PDGFB EGFR
4 glioblastoma multiforme 8.1 PRKCA PDGFB IGF1 EGFR CDC42

Symptoms & Phenotypes for Asbestos-Related Lung Carcinoma

GenomeRNAi Phenotypes related to Asbestos-Related Lung Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.55 CDC42 EGFR PIK3R3 PRKCA PRKX
2 Decreased viability with paclitaxel GR00179-A-1 9.26 EGFR IGF1
3 Decreased viability with paclitaxel GR00179-A-2 9.26 IGF1
4 Decreased viability with paclitaxel GR00179-A-3 9.26 EGFR
5 Increased senescence-associated beta-galactosidase protein expression after pRB stimulation GR00230-A-2 8.62 PRKCA PRKX

Drugs & Therapeutics for Asbestos-Related Lung Carcinoma

Search Clinical Trials , NIH Clinical Center for Asbestos-Related Lung Carcinoma

Genetic Tests for Asbestos-Related Lung Carcinoma

Anatomical Context for Asbestos-Related Lung Carcinoma

MalaCards organs/tissues related to Asbestos-Related Lung Carcinoma:

41
Lung

Publications for Asbestos-Related Lung Carcinoma

Articles related to Asbestos-Related Lung Carcinoma:

# Title Authors PMID Year
1
Pathway deviation-based biomarker and multi-effect target identification in asbestos-related squamous cell carcinoma of the lung. 38
28204826 2017
2
Asbestos-related disease. 38
11933817 2002

Variations for Asbestos-Related Lung Carcinoma

Cosmic variations for Asbestos-Related Lung Carcinoma:

9 (show top 50) (show all 548)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6953383 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1144G>T p.G382C 16:72959002-72959002 6
2 COSM6966579 ZFHX3 lung,NS,carcinoma,undifferentiated carcinoma c.1172A>G p.Q391R 16:72958974-72958974 6
3 COSM6980872 YAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1142C>T p.P381L 11:102229729-102229729 6
4 COSM95548 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 22:41653558-41653558 6
5 COSM95544 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 19:43546970-43546970 6
6 COSM6980399 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.233G>A p.W78* 11:32434909-32434909 6
7 COSM6938307 WT1 lung,NS,carcinoma,undifferentiated carcinoma c.1156A>T p.K386* 11:32392044-32392044 6
8 COSM95531 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.368G>C p.G123A 5:138088927-138088927 6
9 COSM95521 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 12:48966259-48966259 6
10 COSM95485 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 12:6856877-6856877 6
11 COSM95476 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4:143197868-143197868 6
12 COSM96265 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64I 17:60301699-60301699 6
13 COSM94159 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.1555A>G p.S519G 8:102326590-102326590 6
14 COSM94158 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.2691A>T p.Q897H 8:102305221-102305221 6
15 COSM6983597 U2AF1 lung,NS,carcinoma,undifferentiated carcinoma c.319G>C p.D107H 21:43095467-43095467 6
16 COSM95420 TYK2 lung,NS,carcinoma,undifferentiated carcinoma c.3560G>T p.C1187F 19:10350838-10350838 6
17 COSM6942934 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.1922C>T p.S641L 14:81143980-81143980 6
18 COSM6953382 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.937A>C p.K313Q 14:81142995-81142995 6
19 COSM6966576 TSHR lung,NS,carcinoma,undifferentiated carcinoma c.412C>T p.L138F 14:81091088-81091088 6
20 COSM6980873 TSC2 lung,NS,carcinoma,undifferentiated carcinoma c.1840G>T p.A614S 16:2071510-2071510 6
21 COSM6980394 TSC1 lung,NS,carcinoma,undifferentiated carcinoma c.694G>T p.E232* 9:132921406-132921406 6
22 COSM6980408 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1193C>T p.P398L 16:2173978-2173978 6
23 COSM6940747 TRAF7 lung,NS,carcinoma,undifferentiated carcinoma c.1287C>G p.Y429* 16:2174274-2174274 6
24 COSM95390 TRAF5 lung,NS,carcinoma,undifferentiated carcinoma c.302G>C p.R101T 1:211356392-211356392 6
25 COSM22908 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.376-1G>T p.? 17:7675237-7675237 6
26 COSM11232 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.842A>G p.D281G 17:7673778-7673778 6
27 COSM45304 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.375+1G>A p.? 17:7675993-7675993 6
28 COSM10768 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.535C>T p.H179Y 17:7675077-7675077 6
29 COSM10742 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.578A>G p.H193R 17:7674953-7674953 6
30 COSM11333 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.499C>T p.Q167* 17:7675113-7675113 6
31 COSM10779 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>T p.R273L 17:7673802-7673802 6
32 COSM11354 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.991C>T p.Q331* 17:7673537-7673537 6
33 COSM11073 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.1024C>T p.R342* 17:7670685-7670685 6
34 COSM6815 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.461G>T p.G154V 17:7675151-7675151 6
35 COSM43750 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.811G>T p.E271* 17:7673809-7673809 6
36 COSM6913 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.783-1G>T p.? 17:7673838-7673838 6
37 COSM10645 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.527G>T p.C176F 17:7675085-7675085 6
38 COSM44295 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.993+1G>A p.? 17:7673534-7673534 6
39 COSM13584 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.919+1G>T p.? 17:7673700-7673700 6
40 COSM10660 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.818G>A p.R273H 17:7673802-7673802 6
41 COSM43753 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.560-1G>A p.? 17:7674972-7674972 6
42 COSM44240 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.514G>T p.V172F 17:7675098-7675098 6
43 COSM44891 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.796G>T p.G266* 17:7673824-7673824 6
44 COSM10889 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.536A>G p.H179R 17:7675076-7675076 6
45 COSM10714 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.473G>T p.R158L 17:7675139-7675139 6
46 COSM95367 TLR5 lung,NS,carcinoma,undifferentiated carcinoma c.1A>G p.M1V 1:223113031-223113031 6
47 COSM95359 TLR4 lung,NS,carcinoma,undifferentiated carcinoma c.337C>A p.P113T 9:117712465-117712465 6
48 COSM95356 TLR2 lung,NS,carcinoma,undifferentiated carcinoma c.1169A>G p.Q390R 4:153704076-153704076 6
49 COSM95347 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.1087C>T p.P363S 9:35721665-35721665 6
50 COSM95342 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.5624C>T p.S1875L 9:35705660-35705660 6

Expression for Asbestos-Related Lung Carcinoma

Search GEO for disease gene expression data for Asbestos-Related Lung Carcinoma.

Pathways for Asbestos-Related Lung Carcinoma

Pathways related to Asbestos-Related Lung Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 PRKCA PIK3R3 PDGFB IGF1 EGFR CDC42
2
Show member pathways
13.68 PRKCA PIK3R3 PDGFB IGF1 EGFR CDC42
3
Show member pathways
13.51 PRKX PRKCA PIK3R3 PDGFB IGF1 EGFR
4
Show member pathways
13.4 PRKCA PIK3R3 PDGFB IGF1 EGFR
5
Show member pathways
13.37 PRKCA PIK3R3 PDGFB IGF1 EGFR CDC42
6
Show member pathways
13.35 PRKCA PIK3R3 PDGFB EGFR CDC42
7
Show member pathways
13.26 PRKCA PIK3R3 PDGFB IGF1 EGFR CDC42
8
Show member pathways
13.19 PRKCA PIK3R3 PDGFB IGF1 EGFR
9
Show member pathways
13.18 PRKCA PIK3R3 PDGFB IGF1 CDC42
10
Show member pathways
13.14 PRKCA PIK3R3 PDGFB IGF1 EGFR
11
Show member pathways
13.13 PRKCA PIK3R3 PDGFB IGF1 EGFR CDC42
12
Show member pathways
13.08 PRKCA PIK3R3 IGF1 EGFR CDC42
13
Show member pathways
12.96 PRKCA PDGFB EGFR CDC42
14
Show member pathways
12.93 PRKCA PIK3R3 PDGFB IGF1 EGFR
15
Show member pathways
12.91 PRKCA PIK3R3 EGFR CDC42
16
Show member pathways
12.89 PRKCA PIK3R3 IGF1 CDC42
17
Show member pathways
12.85 PRKCA PIK3R3 PDGFB IGF1 EGFR CDC42
18
Show member pathways
12.84 PRKCA PIK3R3 PDGFB EGFR
19
Show member pathways
12.83 PIK3R3 IGF1 EGFR CDC42
20
Show member pathways
12.81 PRKCA PIK3R3 PDGFB CDC42
21
Show member pathways
12.8 PIK3R3 IGF1 EGFR CDC42
22
Show member pathways
12.75 PRKCA PIK3R3 IGF1 EGFR CDC42
23
Show member pathways
12.75 PIK3R3 PDGFB IGF1 EGFR CDC42
24
Show member pathways
12.75 PRKCA PIK3R3 PDGFB IGF1 EGFR CDC42
25
Show member pathways
12.67 PRKCA PIK3R3 IGF1 EGFR
26 12.62 PRKCA PDGFB IGF1 EGFR CDC42
27
Show member pathways
12.61 PRKCA PIK3R3 PDGFB IGF1 EGFR CDC42
28
Show member pathways
12.59 PRKCA PIK3R3 PDGFB EGFR
29
Show member pathways
12.56 PRKCA PIK3R3 PDGFB IGF1 EGFR
30
Show member pathways
12.54 PRKCA PIK3R3 EGFR
31 12.54 PIK3R3 PDGFB EGFR CDC42
32
Show member pathways
12.54 PRKCA PIK3R3 PDGFB IGF1 EGFR
33
Show member pathways
12.53 PRKCA PIK3R3 CDC42
34
Show member pathways
12.52 PRKCA PIK3R3 IGF1 EGFR CDC42
35
Show member pathways
12.48 PIK3R3 PDGFB EGFR
36
Show member pathways
12.48 PRKCA PIK3R3 CDC42
37
Show member pathways
12.48 PIK3R3 IGF1 EGFR CDC42
38 12.46 PRKCA PIK3R3 PDGFB IGF1 EGFR CDC42
39 12.43 PRKCA PDGFB EGFR
40
Show member pathways
12.42 PRKCA PIK3R3 IGF1 EGFR
41
Show member pathways
12.41 PRKCA PIK3R3 CDC42
42
Show member pathways
12.41 PRKCA PIK3R3 PDGFB EGFR CDC42
43
Show member pathways
12.38 PRKCA EGFR CDC42
44
Show member pathways
12.38 PRKCA PIK3R3 PDGFB
45
Show member pathways
12.35 PRKCA EGFR CDC42
46
Show member pathways
12.35 PRKCA PIK3R3 EGFR
47
Show member pathways
12.34 PRKCA PIK3R3 CDC42
48
Show member pathways
12.33 PRKCA PIK3R3 PDGFB EGFR
49
Show member pathways
12.32 PRKCA PIK3R3 EGFR CDC42
50
Show member pathways
12.31 PRKCA PIK3R3 EGFR

GO Terms for Asbestos-Related Lung Carcinoma

Cellular components related to Asbestos-Related Lung Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.62 PDGFB IGF1

Biological processes related to Asbestos-Related Lung Carcinoma according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.73 PRKCA PDGFB EGFR
2 positive regulation of MAP kinase activity GO:0043406 9.61 PDGFB EGFR
3 positive regulation of epithelial cell proliferation GO:0050679 9.61 IGF1 EGFR
4 cellular response to growth factor stimulus GO:0071363 9.6 PDGFB EGFR
5 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.59 PDGFB IGF1
6 positive regulation of blood vessel endothelial cell migration GO:0043536 9.58 PRKCA PDGFB
7 protein kinase B signaling GO:0043491 9.58 PIK3R3 IGF1
8 peptidyl-serine phosphorylation GO:0018105 9.58 PRKX PRKCA PDGFB
9 activation of protein kinase B activity GO:0032148 9.57 PDGFB IGF1
10 ERBB2 signaling pathway GO:0038128 9.55 PRKCA EGFR
11 negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 9.54 EGFR CDC42
12 positive regulation of DNA replication GO:0045740 9.52 EGFR CDC42
13 positive regulation of mitotic nuclear division GO:0045840 9.51 PDGFB IGF1
14 positive regulation of cardiac muscle hypertrophy GO:0010613 9.49 PRKCA IGF1
15 embryonic placenta development GO:0001892 9.48 PDGFB EGFR
16 positive regulation of smooth muscle cell migration GO:0014911 9.46 PDGFB IGF1
17 positive regulation of bone resorption GO:0045780 9.43 PRKCA EGFR
18 positive regulation of smooth muscle cell proliferation GO:0048661 9.43 PDGFB IGF1 EGFR
19 positive regulation of MAPK cascade GO:0043410 9.37 PDGFB IGF1
20 positive regulation of fibroblast proliferation GO:0048146 9.33 PDGFB IGF1 EGFR
21 protein phosphorylation GO:0006468 9.26 PRKX PRKCA PDGFB EGFR
22 phosphatidylinositol phosphorylation GO:0046854 9.02 PIK3R3
23 positive regulation of cell migration GO:0030335 9.02 PRKCA PIK3R3 PDGFB IGF1 EGFR

Molecular functions related to Asbestos-Related Lung Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 8.8 PRKCA IGF1 EGFR

Sources for Asbestos-Related Lung Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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