MCID: ASB001
MIFTS: 43

Asbestosis

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Asbestosis

MalaCards integrated aliases for Asbestosis:

Name: Asbestosis 12 76 53 55 44 15 73
Idiopathic Interstitial Pneumonitis - from Asbestos Exposure 53
Pulmonary Fibrosis - from Asbestos Exposure 53

Classifications:



External Ids:

Disease Ontology 12 DOID:10320
ICD10 33 J61
ICD9CM 35 501
MeSH 44 D001195
NCIt 50 C84573
UMLS 73 C0003949

Summaries for Asbestosis

Disease Ontology : 12 A pneumoconiosis caused by inhalation and retention of asbestos fibers.

MalaCards based summary : Asbestosis, also known as idiopathic interstitial pneumonitis - from asbestos exposure, is related to larynx cancer and pulmonary disease, chronic obstructive. An important gene associated with Asbestosis is GSTM1 (Glutathione S-Transferase Mu 1), and among its related pathways/superpathways are Pathways in cancer and Folate Metabolism. The drugs Artichoke and Respiratory System Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and testes, and related phenotype is Synthetic lethal with paclitaxel.

Wikipedia : 76 Asbestosis is long term inflammation and scarring of the lungs due to asbestos. Symptoms may include... more...

Related Diseases for Asbestosis

Diseases related to Asbestosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 larynx cancer 29.6 GSTM1 GSTP1 GSTT1
2 pulmonary disease, chronic obstructive 27.9 GSTM1 GSTP1 IL6 SERPINA1 SOD3
3 asbestos intoxication 11.1
4 interstitial lung disease 11.0
5 hearing loss, noise-induced 10.7 GSTM1 GSTT1
6 sister chromatid exchange, frequency of 10.7 GSTM1 GSTT1
7 isolated cleft lip 10.7 GSTM1 GSTT1
8 drug-induced hepatitis 10.7 GSTM1 GSTT1
9 leukoplakia 10.6 GSTM1 GSTT1
10 mutagen sensitivity 10.6 GSTM1 GSTT1
11 arteritic anterior ischemic optic neuropathy 10.6 GSTM1 GSTT1
12 senile cataract 10.6 GSTM1 GSTT1
13 lung cancer 10.5
14 diabetic polyneuropathy 10.4 SOD2 SOD3
15 oligospermia 10.4 GSTM1 GSTT1
16 silicosis 10.3
17 ischemic optic neuropathy 10.3 GSTM1 GSTT1
18 anca-associated vasculitis 10.2 IL6 SERPINA1
19 transient arthritis 10.2 IL6 SERPINA1
20 oral submucous fibrosis 10.2 GSTM1 GSTT1
21 pulmonary fibrosis 10.2
22 neonatal jaundice 10.1 GSTM1 IL6
23 pneumoconiosis 10.1
24 fibromyalgia 10.1 IL6 SERPINA1
25 diffuse gastric cancer 10.1 GSTM1 GSTP1 GSTT1
26 pulmonary fibrosis, idiopathic 10.1
27 adenocarcinoma 10.0
28 pleural disease 10.0
29 pneumonia 10.0
30 viral meningitis 9.9 IL6 SERPINA1
31 cystadenofibroma 9.9 MUC1 SERPINA1
32 aging 9.9
33 gastric cancer 9.9
34 anthracosis 9.9
35 pulmonary tuberculosis 9.9
36 lung disease 9.9
37 secretory meningioma 9.8 MUC1 SERPINA1
38 malignant fibroxanthoma 9.8 MUC1 SERPINA1
39 coloboma, ocular, autosomal dominant 9.8
40 small cell cancer of the lung 9.8
41 berylliosis 9.8
42 laryngitis 9.8
43 malignant pleural mesothelioma 9.8
44 peritonitis 9.8
45 aplastic anemia 9.8 GSTM1 GSTT1 IL6
46 xeroderma pigmentosum, complementation group d 9.8 GSTM1 GSTP1 GSTT1 OGG1
47 squamous cell carcinoma, head and neck 9.7 GSTM1 GSTP1 GSTT1
48 autoimmune disease 9.7
49 systemic lupus erythematosus 9.7
50 neutrophil migration 9.7

Comorbidity relations with Asbestosis via Phenotypic Disease Network (PDN): (show all 12)


Bronchitis Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Intermediate Coronary Syndrome Ischemic Heart Disease
Postinflammatory Pulmonary Fibrosis Prostate Cancer
Prostatic Hypertrophy Respiratory Failure

Graphical network of the top 20 diseases related to Asbestosis:



Diseases related to Asbestosis

Symptoms & Phenotypes for Asbestosis

GenomeRNAi Phenotypes related to Asbestosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with paclitaxel GR00101-A-3 8.62 KIF5A SOD2

Drugs & Therapeutics for Asbestosis

Drugs for Asbestosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Artichoke Approved, Nutraceutical Phase 2
2 Respiratory System Agents
3 Xenon Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Investigation of the Anti-Cancer Activity of Artichoke Extract in an Asbestos-Exposed Population Completed NCT02076672 Phase 2 Artichoke WPC
2 Oscillation Mechanics of the Respiratory System Asbestos Exposed: Early Diagnosis Unknown status NCT02280343
3 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
4 Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders Not yet recruiting NCT02748798 Early Phase 1 HP 3He;HP 129Xe;PFP;SF6

Search NIH Clinical Center for Asbestosis

Cochrane evidence based reviews: asbestosis

Genetic Tests for Asbestosis

Anatomical Context for Asbestosis

MalaCards organs/tissues related to Asbestosis:

41
Lung, Heart, Testes, Neutrophil, Nk Cells, T Cells, Bone Marrow

Publications for Asbestosis

Articles related to Asbestosis:

(show top 50) (show all 531)
# Title Authors Year
1
Temporal Patterns of Exposure to Asbestos and Risk of Asbestosis: An Analysis of a Cohort of Asbestos Textile Workers. ( 29334525 )
2018
2
Grade 4 asbestosis does not extend directly from the respiratory bronchiole to the peripheral lung. ( 29464753 )
2018
3
Asbestosis is prevalent in a variety of construction industry trades. ( 29615629 )
2018
4
Memory of World War II with loud atypical friction rub due to pulmonary asbestosis. ( 29054957 )
2017
5
Correlation of ultra-low dose chest CT findings with physiologic measures of asbestosis. ( 28083692 )
2017
6
Serum concentrations of Krebs von den Lungen-6, surfactant protein D, and matrix metalloproteinase-2 as diagnostic biomarkers in patients with asbestosis and silicosis: a case-control study. ( 29149883 )
2017
7
Asbestos, asbestosis, and cancer: The Helsinki criteria for diagnosis and attribution. Critical need for revision of the 2014 update. ( 28409857 )
2017
8
Association between increased small airway obstruction and asbestos exposure in patients with asbestosis. ( 29087047 )
2017
9
MicroRNA Expression in Malignant Pleural Mesothelioma and Asbestosis: A Pilot Study. ( 28757678 )
2017
10
Parenchymal asbestosis due to primary asbestos exposure among ship-breaking workers: report of the first cases from Bangladesh. ( 29102973 )
2017
11
Usual interstitial pneumonia in asbestos exposed cohorts - concurrent idiopathic pulmonary fibrosis or atypical asbestosis? ( 26864248 )
2016
12
Pathology of Asbestosis: An Update of the Diagnostic Criteria Response to a Critique. ( 27575267 )
2016
13
Exposure-response estimate for lung cancer and asbestosis in a predominantly chrysotile-exposed Chinese factory cohort. ( 26969815 )
2016
14
Collegium Ramazzini response to 'Asbestos, asbestosis, and cancer, the Helsinki criteria for diagnosis and attribution 2014: recommendations'. ( 26637163 )
2016
15
The comparison of high-resolution computed tomography findings in asbestosis and idiopathic pulmonary fibrosis. ( 26901505 )
2016
16
Radiologic Diagnosis of Asbestosis in Korea. ( 27587956 )
2016
17
Learning to identify the benign thoracic manifestations of asbestosis from a single patient. ( 27302641 )
2016
18
Carcinoma of the lung in the absence of asbestosis: The value of lung fiber burden analysis. ( 27043967 )
2016
19
Pleural plaques in smoking-associated fibrosis and pulmonary asbestosis. ( 25999705 )
2015
20
Commentary on pathologic diagnosis of asbestosis and critique of the 2010 Asbestosis Committee of the College of American Pathologists (CAP) and Pulmonary Pathology Society's (PPS) update on the diagnostic criteria for pathologic asbestosis. ( 26374489 )
2015
21
Asbestosis and environmental causes of usual interstitial pneumonia. ( 25621562 )
2015
22
Retroperitoneal fibrosis and asbestosis--a plausible association? ( 25445100 )
2015
23
Occupationally acquired asbestosis in a healthcare worker. ( 26253085 )
2015
24
Systemic autoimmune disease in asbestosis rapidly responding to anti-interleukin-1beta antibody canakinumab: a case report. ( 26071911 )
2015
25
Pathological confirmed diagnosis of asbestosis: the first case report in Thailand. ( 25920303 )
2015
26
Asbestosis: The Scam That Refuses to Die. ( 26168581 )
2015
27
Risk assessment of gastric cancer associated with asbestosis: a case report. ( 25908993 )
2015
28
Asbestosis in a Japanese Macaque (Macaca fuscata). ( 26056144 )
2015
29
Parenchymal asbestosis can lead to lung cancer within a short time frame: more frequent follow-up surveillance is needed than currently recommended. ( 25878233 )
2015
30
Asbestosis and other pulmonary fibrosis in asbestos-exposed workers: high-resolution CT features with pathological correlations. ( 26334510 )
2015
31
Iron and Iron-Related Proteins in Asbestosis. ( 26756421 )
2015
32
Smoking-associated fibrosis and pulmonary asbestosis. ( 25565798 )
2015
33
Inter-reader agreement in HRCT detection of pleural plaques and asbestosis in participants with previous occupational exposure to asbestos. ( 25286915 )
2014
34
Asbestos, asbestosis, and cancer, the Helsinki criteria for diagnosis and attribution 2014: recommendations. ( 25299403 )
2014
35
0043a88Benign pleural abnormalities and mesothelioma among asbestosis workers in Hong Kong. ( 25018430 )
2014
36
Reply: asbestos, asbestosis, smoking, and lung cancer: study bias and confounding issues that complicate the interpretation of the results. ( 24381998 )
2014
37
Pulmonary tuberculosis complicating asbestosis. ( 24914084 )
2014
38
Asbestosis, not asbestos exposure, is the primary risk factor for lung cancer. ( 24381996 )
2014
39
Asbestos, asbestosis, smoking, and lung cancer: study bias and confounding issues that complicate the interpretation of the results. ( 24381997 )
2014
40
Asbestos, asbestosis, smoking, and lung cancer. New findings from the North American insulator cohort. ( 23590275 )
2013
41
The influence of gene-gene and gene-environment interactions on the risk of asbestosis. ( 23984360 )
2013
42
YKL-40 and Mesothelin in the Blood of Patients with Malignant Mesothelioma, Lung Cancer and Asbestosis. ( 24324091 )
2013
43
Bronchoalveolar neutrophilia inversely correlates with DLCO at diagnosis in asbestosis but not lung function decline at 1 year. ( 23825766 )
2013
44
Descriptive review of asbestosis and silicosis hospitalization trends in North Carolina, 2002-2011. ( 24165760 )
2013
45
Mesothelioma and lung cancer mortality: a historical cohort study among asbestosis workers in Hong Kong. ( 22129857 )
2012
46
Cryptococcus pneumonia presenting in an immunocompetent host with pulmonary asbestosis: a case report. ( 22742509 )
2012
47
Mortality from asbestosis and mesothelioma in Britain by birth cohort. ( 23034792 )
2012
48
Pulmonary tuberculosis and lung cancer mortality in a historical cohort of workers with asbestosis. ( 23164612 )
2012
49
Asbestosis: Past voices from the Mumbai factory floor. ( 23776323 )
2012
50
Exposure-response relationship between chrysotile exposure and mortality from lung cancer and asbestosis. ( 21742741 )
2012

Variations for Asbestosis

Expression for Asbestosis

Search GEO for disease gene expression data for Asbestosis.

Pathways for Asbestosis

Pathways related to Asbestosis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1 12.48 GSTM1 GSTP1 GSTT1 IL6
2
Show member pathways
12.02 IL6 SOD2 SOD3
3
Show member pathways
11.98 GSTM1 GSTP1 GSTT1
4 11.75 GSTM1 GSTP1 GSTT1
5 11.62 GSTM1 GSTP1 SERPINA1 SOD3
6
Show member pathways
11.44 GSTM1 GSTP1 GSTT1
7 11.36 GSTM1 GSTP1 GSTT1
8
Show member pathways
11.17 GSTM1 GSTP1
9
Show member pathways
11.17 GSTP1 SOD2 SOD3
10 10.97 SOD2 SOD3
11 10.59 GSTM1 GSTP1 GSTT1
12 10.58 GSTP1 GSTT1
13 10.18 GSTM1 GSTP1 GSTT1

GO Terms for Asbestosis

Cellular components related to Asbestosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.5 CHI3L1 GSTP1 GSTT1 MUC1 SERPINA1 SOD2
2 extracellular space GO:0005615 9.1 CHI3L1 GSTP1 IL6 MUC1 SERPINA1 SOD3

Biological processes related to Asbestosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to oxidative stress GO:0034599 9.43 GSTP1 SOD2 SOD3
2 acute-phase response GO:0006953 9.4 IL6 SERPINA1
3 superoxide metabolic process GO:0006801 9.37 SOD2 SOD3
4 cellular oxidant detoxification GO:0098869 9.33 GSTP1 GSTT1 SOD3
5 removal of superoxide radicals GO:0019430 9.32 SOD2 SOD3
6 glutathione metabolic process GO:0006749 9.13 GSTM1 GSTP1 GSTT1
7 glutathione derivative biosynthetic process GO:1901687 8.8 GSTM1 GSTP1 GSTT1

Molecular functions related to Asbestosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP-dependent microtubule motor activity, plus-end-directed GO:0008574 9.32 KIF18A KIF5A
2 glutathione peroxidase activity GO:0004602 9.26 GSTP1 GSTT1
3 glutathione binding GO:0043295 9.16 GSTM1 GSTP1
4 superoxide dismutase activity GO:0004784 8.96 SOD2 SOD3
5 glutathione transferase activity GO:0004364 8.8 GSTM1 GSTP1 GSTT1

Sources for Asbestosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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