MCID: ASB001
MIFTS: 43

Asbestosis

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Asbestosis

MalaCards integrated aliases for Asbestosis:

Name: Asbestosis 12 77 54 56 45 15 17 74
Idiopathic Interstitial Pneumonitis - from Asbestos Exposure 54
Pulmonary Fibrosis - from Asbestos Exposure 54

Classifications:



External Ids:

Disease Ontology 12 DOID:10320
ICD9CM 36 501
MeSH 45 D001195
NCIt 51 C84573
SNOMED-CT 69 22607003
ICD10 34 J61
UMLS 74 C0003949

Summaries for Asbestosis

Disease Ontology : 12 A pneumoconiosis caused by inhalation and retention of asbestos fibers.

MalaCards based summary : Asbestosis, also known as idiopathic interstitial pneumonitis - from asbestos exposure, is related to pneumoconiosis and lung disease. An important gene associated with Asbestosis is GSTM1 (Glutathione S-Transferase Mu 1), and among its related pathways/superpathways are Selenium Micronutrient Network and NRF2 pathway. The drugs Artichoke and Xenon have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and testes, and related phenotypes are Synthetic lethal with paclitaxel and cellular

Wikipedia : 77 Asbestosis is long term inflammation and scarring of the lungs due to asbestos fibres. Symptoms may... more...

Related Diseases for Asbestosis

Diseases related to Asbestosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 pneumoconiosis 30.3 GSTM1 IL6 SERPINA1
2 lung disease 29.8 IL6 SERPINA1 SOD3
3 extrinsic allergic alveolitis 29.6 IL6 SOD2
4 pulmonary disease, chronic obstructive 29.2 GSTM1 IL6 SERPINA1 SOD3
5 asbestos intoxication 11.9
6 interstitial lung disease 11.2
7 lung cancer 10.7
8 silicosis 10.6
9 pulmonary fibrosis 10.4
10 hearing loss, noise-induced 10.3 GSTM1 GSTT1
11 pulmonary fibrosis, idiopathic 10.3
12 adenocarcinoma 10.3
13 sister chromatid exchange, frequency of 10.3 GSTM1 GSTT1
14 isolated cleft lip 10.3 GSTM1 GSTT1
15 drug-induced hepatitis 10.2 GSTM1 GSTT1
16 cardia cancer 10.2 GSTM1 GSTT1
17 leukoplakia 10.2 GSTM1 GSTT1
18 mutagen sensitivity 10.2 GSTM1 GSTT1
19 arteritic anterior ischemic optic neuropathy 10.2 GSTM1 GSTT1
20 ischemic optic neuropathy 10.2 GSTM1 GSTT1
21 pleural disease 10.2
22 senile cataract 10.2 GSTM1 GSTT1
23 diffuse gastric cancer 10.2 GSTM1 GSTT1
24 benign mesothelioma 10.1
25 pneumonia 10.1
26 laryngeal disease 10.1 GSTM1 GSTT1
27 diabetic polyneuropathy 10.1 SOD2 SOD3
28 oligospermia 10.1 GSTM1 GSTT1
29 xeroderma pigmentosum, complementation group d 10.1 GSTM1 GSTT1 OGG1
30 popliteal pterygium syndrome 10.1
31 mesothelioma, malignant 10.1
32 gastric cancer 10.1
33 anthracosis 10.1
34 bronchus cancer 10.1
35 pulmonary tuberculosis 10.1
36 oral submucous fibrosis 10.1 GSTM1 GSTT1
37 varicocele 10.0 GSTM1 GSTT1
38 coloboma, ocular, autosomal dominant 10.0
39 berylliosis 10.0
40 sarcoma 10.0
41 bronchitis 10.0
42 malignant pleural mesothelioma 10.0
43 anca-associated vasculitis 10.0 IL6 SERPINA1
44 viral meningitis 9.9 IL6 SERPINA1
45 transient arthritis 9.9 IL6 SERPINA1
46 fibromyalgia 9.9 IL6 SERPINA1
47 oral cavity cancer 9.9 GSTM1 GSTT1 SOD2
48 neonatal jaundice 9.9 GSTM1 IL6
49 autoimmune disease 9.8
50 systemic lupus erythematosus 9.8

Comorbidity relations with Asbestosis via Phenotypic Disease Network (PDN): (show all 12)


Bronchitis Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Intermediate Coronary Syndrome Ischemic Heart Disease
Postinflammatory Pulmonary Fibrosis Prostate Cancer
Prostatic Hypertrophy Respiratory Failure

Graphical network of the top 20 diseases related to Asbestosis:



Diseases related to Asbestosis

Symptoms & Phenotypes for Asbestosis

GenomeRNAi Phenotypes related to Asbestosis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with paclitaxel GR00101-A-3 8.62 KIF5A SOD2

MGI Mouse Phenotypes related to Asbestosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.17 CHI3L1 IL6 KIF18A KIF5A OGG1 SOD2

Drugs & Therapeutics for Asbestosis

Drugs for Asbestosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Artichoke Approved Phase 2
2 Xenon Experimental Early Phase 1 7440-63-3
3 Respiratory System Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Investigation of the Anti-Cancer Activity of Artichoke Extract in an Asbestos-Exposed Population Not yet recruiting NCT02076672 Phase 2 Artichoke WPC
2 Oscillation Mechanics of the Respiratory System Asbestos Exposed: Early Diagnosis Unknown status NCT02280343
3 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
4 It's Not JUST Idiopathic Pulmonary Fibrosis Study Recruiting NCT03670576
5 Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Prospective Outcomes Registry Recruiting NCT01915511
6 Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders Not yet recruiting NCT02748798 Early Phase 1 HP 3He;HP 129Xe;PFP;SF6

Search NIH Clinical Center for Asbestosis

Cochrane evidence based reviews: asbestosis

Genetic Tests for Asbestosis

Anatomical Context for Asbestosis

MalaCards organs/tissues related to Asbestosis:

42
Lung, Heart, Testes, Neutrophil, Bone, Lymph Node, Bone Marrow

Publications for Asbestosis

Articles related to Asbestosis:

(show top 50) (show all 653)
# Title Authors Year
1
Asbestosis and silicosis hospitalizations in Italy (2001-2015): results from the National Hospital Discharge Registry. ( 30753424 )
2019
2
An outbreak of cancer and asbestosis among former amosite-exposed subjects in Ledro Valley, Italy. From discovery to environmental cleanup. ( 30968842 )
2019
3
Grade 4 asbestosis does not extend directly from the respiratory bronchiole to the peripheral lung. ( 29464753 )
2018
4
Asbestosis is prevalent in a variety of construction industry trades. ( 29615629 )
2018
5
Occupational Burden of Asbestos-Related Diseases in Korea, 1998-2013: Asbestosis, Mesothelioma, Lung Cancer, Laryngeal Cancer, and Ovarian Cancer. ( 30140191 )
2018
6
Temporal Patterns of Exposure to Asbestos and Risk of Asbestosis: An Analysis of a Cohort of Asbestos Textile Workers. ( 29334525 )
2018
7
Association between increased small airway obstruction and asbestos exposure in patients with asbestosis. ( 29087047 )
2018
8
Serum concentrations of Krebs von den Lungen-6, surfactant protein D, and matrix metalloproteinase-2 as diagnostic biomarkers in patients with asbestosis and silicosis: a case-control study. ( 29149883 )
2017
9
Parenchymal asbestosis due to primary asbestos exposure among ship-breaking workers: report of the first cases from Bangladesh. ( 29102973 )
2017
10
Memory of World War II with loud atypical friction rub due to pulmonary asbestosis. ( 29054957 )
2017
11
MicroRNA Expression in Malignant Pleural Mesothelioma and Asbestosis: A Pilot Study. ( 28757678 )
2017
12
Asbestos, asbestosis, and cancer: The Helsinki criteria for diagnosis and attribution. Critical need for revision of the 2014 update. ( 28409857 )
2017
13
Correlation of ultra-low dose chest CT findings with physiologic measures of asbestosis. ( 28083692 )
2017
14
Radiologic Diagnosis of Asbestosis in Korea. ( 27587956 )
2016
15
Pathology of Asbestosis: An Update of the Diagnostic Criteria Response to a Critique. ( 27575267 )
2016
16
Learning to identify the benign thoracic manifestations of asbestosis from a single patient. ( 27302641 )
2016
17
Carcinoma of the lung in the absence of asbestosis: The value of lung fiber burden analysis. ( 27043967 )
2016
18
Exposure-response estimate for lung cancer and asbestosis in a predominantly chrysotile-exposed Chinese factory cohort. ( 26969815 )
2016
19
The comparison of high-resolution computed tomography findings in asbestosis and idiopathic pulmonary fibrosis. ( 26901505 )
2016
20
Usual interstitial pneumonia in asbestos-exposed cohorts - concurrent idiopathic pulmonary fibrosis or atypical asbestosis? ( 26864248 )
2016
21
Collegium Ramazzini response to 'Asbestos, asbestosis, and cancer, the Helsinki criteria for diagnosis and attribution 2014: recommendations'. ( 26637163 )
2016
22
Asbestosis and other pulmonary fibrosis in asbestos-exposed workers: high-resolution CT features with pathological correlations. ( 26334510 )
2016
23
Iron and Iron-Related Proteins in Asbestosis. ( 26756421 )
2015
24
Commentary on pathologic diagnosis of asbestosis and critique of the 2010 Asbestosis Committee of the College of American Pathologists (CAP) and Pulmonary Pathology Society's (PPS) update on the diagnostic criteria for pathologic asbestosis. ( 26374489 )
2015
25
Occupationally acquired asbestosis in a healthcare worker. ( 26253085 )
2015
26
Asbestosis: The Scam That Refuses to Die. ( 26168581 )
2015
27
Systemic autoimmune disease in asbestosis rapidly responding to anti-interleukin-1beta antibody canakinumab: a case report. ( 26071911 )
2015
28
Asbestosis in a Japanese Macaque (Macaca fuscata). ( 26056144 )
2015
29
Pleural plaques in smoking-associated fibrosis and pulmonary asbestosis. ( 25999705 )
2015
30
Pathological confirmed diagnosis of asbestosis: the first case report in Thailand. ( 25920303 )
2015
31
Risk assessment of gastric cancer associated with asbestosis: a case report. ( 25908993 )
2015
32
Parenchymal asbestosis can lead to lung cancer within a short time frame: more frequent follow-up surveillance is needed than currently recommended. ( 25878233 )
2015
33
Asbestosis and environmental causes of usual interstitial pneumonia. ( 25621562 )
2015
34
Smoking-associated fibrosis and pulmonary asbestosis. ( 25565798 )
2015
35
Retroperitoneal fibrosis and asbestosis--a plausible association? ( 25445100 )
2015
36
Asbestos, asbestosis, and cancer, the Helsinki criteria for diagnosis and attribution 2014: recommendations. ( 25299403 )
2015
37
Inter-reader agreement in HRCT detection of pleural plaques and asbestosis in participants with previous occupational exposure to asbestos. ( 25286915 )
2014
38
Pulmonary tuberculosis complicating asbestosis. ( 24914084 )
2014
39
Asbestos, asbestosis, smoking, and lung cancer: study bias and confounding issues that complicate the interpretation of the results. ( 24381997 )
2014
40
Asbestosis, not asbestos exposure, is the primary risk factor for lung cancer. ( 24381996 )
2014
41
YKL-40 and mesothelin in the blood of patients with malignant mesothelioma, lung cancer and asbestosis. ( 24324091 )
2013
42
Descriptive review of asbestosis and silicosis hospitalization trends in North Carolina, 2002-2011. ( 24165760 )
2013
43
The influence of gene-gene and gene-environment interactions on the risk of asbestosis. ( 23984360 )
2013
44
Bronchoalveolar neutrophilia inversely correlates with DLCO at diagnosis in asbestosis but not lung function decline at 1 year. ( 23825766 )
2013
45
Asbestos, asbestosis, smoking, and lung cancer. New findings from the North American insulator cohort. ( 23590275 )
2013
46
Mortality from asbestosis and mesothelioma in Britain by birth cohort. ( 23034792 )
2012
47
Cryptococcus pneumonia presenting in an immunocompetent host with pulmonary asbestosis: a case report. ( 22742509 )
2012
48
Mesothelioma and lung cancer mortality: a historical cohort study among asbestosis workers in Hong Kong. ( 22129857 )
2012
49
Exposure-response relationship between chrysotile exposure and mortality from lung cancer and asbestosis. ( 21742741 )
2012
50
Asbestosis: Past voices from the Mumbai factory floor. ( 23776323 )
2012

Variations for Asbestosis

Expression for Asbestosis

Search GEO for disease gene expression data for Asbestosis.

Pathways for Asbestosis

GO Terms for Asbestosis

Cellular components related to Asbestosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinesin complex GO:0005871 8.62 KIF18A KIF5A

Biological processes related to Asbestosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione metabolic process GO:0006749 9.32 GSTM1 GSTT1
2 acute-phase response GO:0006953 9.26 IL6 SERPINA1
3 glutathione derivative biosynthetic process GO:1901687 9.16 GSTM1 GSTT1
4 superoxide metabolic process GO:0006801 8.96 SOD2 SOD3
5 removal of superoxide radicals GO:0019430 8.62 SOD2 SOD3

Molecular functions related to Asbestosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule binding GO:0008017 9.43 KIF18A KIF5A OGG1
2 ATP-dependent microtubule motor activity, plus-end-directed GO:0008574 9.16 KIF18A KIF5A
3 glutathione transferase activity GO:0004364 8.96 GSTM1 GSTT1
4 superoxide dismutase activity GO:0004784 8.62 SOD2 SOD3

Sources for Asbestosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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