MCID: ASB001
MIFTS: 47

Asbestosis

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Asbestosis

MalaCards integrated aliases for Asbestosis:

Name: Asbestosis 12 73 20 54 44 15 17 70
Idiopathic Interstitial Pneumonitis - from Asbestos Exposure 20
Pulmonary Fibrosis - from Asbestos Exposure 20

Classifications:



External Ids:

Disease Ontology 12 DOID:10320
ICD9CM 34 501
MeSH 44 D001195
NCIt 50 C84573
SNOMED-CT 67 266400008
ICD10 32 J61
UMLS 70 C0003949

Summaries for Asbestosis

Disease Ontology : 12 A pneumoconiosis caused by inhalation and retention of asbestos fibers.

MalaCards based summary : Asbestosis, also known as idiopathic interstitial pneumonitis - from asbestos exposure, is related to benign mesothelioma and pneumoconiosis. An important gene associated with Asbestosis is GSTM1 (Glutathione S-Transferase Mu 1), and among its related pathways/superpathways are Pathways in cancer and Selenium Micronutrient Network. The drugs Nintedanib and Artichoke have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and neutrophil, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 73 Asbestosis is long-term inflammation and scarring of the lungs due to asbestos fibers. Symptoms may... more...

Related Diseases for Asbestosis

Diseases related to Asbestosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 207)
# Related Disease Score Top Affiliating Genes
1 benign mesothelioma 31.0 WT1 THBD MSLN CALB2
2 pneumoconiosis 30.6 SOD2 SERPINA1 OGG1 NLRP3 IL6 GSTM1
3 pleural disease 30.5 MSLN IL6 CHI3L1 CALB2
4 bronchitis 30.5 SERPINA1 MPO IL6 GSTM1
5 lung disease 30.5 SOD3 SERPINA1 MUC1 MPO IL6
6 peritoneal mesothelioma 30.3 WT1 THBD MUC1 CALB2
7 pleural cancer 30.1 WT1 MSLN CALB2
8 pneumonia 30.1 SERPINA1 MUC1 MPO IL6
9 extrinsic allergic alveolitis 30.0 SOD2 MPO IL6
10 mesothelioma, malignant 30.0 WT1 THBD SOD2 MUC1 MSLN CALB2
11 mycobacterium abscessus 29.9 SERPINA1 NLRP3
12 pneumothorax 29.9 SERPINA1 MUC1 CALB2
13 malignant pleural mesothelioma 29.8 WT1 THBD MUC1 MSLN CALB2
14 constrictive pericarditis 29.7 SERPINA1 CALB2
15 respiratory failure 29.7 THBD SERPINA1 MPO IL6
16 malignant biphasic mesothelioma 29.5 WT1 THBD MSLN CALB2
17 vasculitis 29.4 THBD SERPINA1 MPO IL6
18 pulmonary fibrosis, idiopathic 29.4 THBD SERPINA1 NOX4 MUC1 MPO IL6
19 pulmonary disease, chronic obstructive 29.4 SOD3 SERPINA1 MPO IL6 GSTP1 GSTM1
20 vascular disease 28.6 THBD NOX4 NOS2 MPO IL6
21 asbestos intoxication 11.5
22 anthracosis 11.2
23 interstitial lung disease 11.0
24 silicosis 10.6
25 pulmonary fibrosis 10.6
26 hearing loss, noise-induced 10.4 GSTT1 GSTM1
27 sister chromatid exchange, frequency of 10.4 GSTT1 GSTM1
28 thyroid tumor 10.4 GSTT1 GSTM1
29 isolated cleft lip 10.4 GSTT1 GSTM1
30 mucinous cystadenofibroma 10.3 SERPINA1 MUC1
31 oral leukoplakia 10.3 GSTT1 GSTM1
32 multiple chemical sensitivity 10.3 SOD2 GSTP1 GSTM1
33 senile cataract 10.3 OGG1 GSTT1 GSTM1
34 spindle cell thymoma 10.3 MUC1 CALB2
35 gastroesophageal adenocarcinoma 10.3 GSTT1 GSTP1 GSTM1
36 cardia cancer 10.3 GSTT1 GSTP1 GSTM1
37 diffuse gastric cancer 10.3 GSTT1 GSTP1 GSTM1
38 ovarian mixed germ cell neoplasm 10.3 WT1 SERPINA1
39 fallopian tube carcinosarcoma 10.3 WT1 CALB2
40 fibrosis of extraocular muscles, congenital, 1 10.3
41 pancreatic mucinous cystadenoma 10.3 MUC1 CALB2
42 anca-associated vasculitis 10.3 SERPINA1 MPO
43 oligospermia 10.3 GSTT1 GSTP1 GSTM1
44 epididymal neoplasm 10.2 WT1 CALB2
45 pericardial mesothelioma 10.2 MUC1 CALB2
46 testicular fibroma 10.2 WT1 CALB2
47 wolffian duct adenocarcinoma 10.2 WT1 CALB2
48 alcoholic liver cirrhosis 10.2 SOD2 IL6 GSTM1
49 ovarian endometrioid stromal sarcoma 10.2 WT1 CALB2
50 juvenile type testicular granulosa cell tumor 10.2 WT1 CALB2

Comorbidity relations with Asbestosis via Phenotypic Disease Network (PDN):


Bronchitis Chronic Pulmonary Heart Disease
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Intermediate Coronary Syndrome
Postinflammatory Pulmonary Fibrosis Prostate Cancer
Prostatic Hypertrophy Respiratory Failure

Graphical network of the top 20 diseases related to Asbestosis:



Diseases related to Asbestosis

Symptoms & Phenotypes for Asbestosis

GenomeRNAi Phenotypes related to Asbestosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.58 MUC1
2 Decreased viability GR00055-A-2 9.58 MUC1
3 Decreased viability GR00249-S 9.58 GSTM1 GSTP1 KIF18A KIF5A MSLN MUC1
4 Decreased viability GR00381-A-1 9.58 GSTM1 WT1
5 Decreased viability GR00386-A-1 9.58 GSTM1 GSTP1 KIF18A NLRP3
6 Decreased viability GR00402-S-2 9.58 NOX4 OGG1

MGI Mouse Phenotypes related to Asbestosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10 CHI3L1 IL6 KIF18A KIF5A NLRP3 NOS2
2 immune system MP:0005387 9.9 CHI3L1 IL6 MPO NLRP3 NOS2 NOX4
3 mortality/aging MP:0010768 9.77 IL6 KIF18A KIF5A MPO NLRP3 NOS2
4 normal MP:0002873 9.28 CALB2 KIF5A MSLN NLRP3 OGG1 SERPINA1

Drugs & Therapeutics for Asbestosis

Drugs for Asbestosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nintedanib Approved Phase 2 656247-17-5 56843413
2 Artichoke Approved Phase 2
3
Xenon Experimental Early Phase 1 7440-63-3
4 Respiratory System Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Nintedanib in Progressive Pneumoconiosis Study (NiPPS): a Collaborative NSW Treatment Trial Recruiting NCT04161014 Phase 2 Nintedanib 150 MG [Ofev]
2 Investigation of the Anti-Cancer Activity of Artichoke Extract in an Asbestos-Exposed Population (The ABOCA Phase II Trial) Terminated NCT02076672 Phase 2 Artichoke WPC
3 OSCILLATION MECHANICS OF THE RESPIRATORY SYSTEM ASBESTOS EXPOSED : Early Diagnosis Unknown status NCT02280343
4 Developing Optimal Parameters for Hyperpolarized Noble Gas (3He and 129Xe) and Inert Fluorinated Gas Magnetic Resonance Imaging of Lung Disorders Unknown status NCT02748798 Early Phase 1 HP 3He;HP 129Xe;PFP;SF6
5 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
6 Effects of Silica and Asbestos Fibres on the Efferocytosis Capacities of Macrophages Recruiting NCT04473742
7 The Edinburgh Lung Fibrosis Molecular Endotyping (ELFMEN) Study Enrolling by invitation NCT04016181

Search NIH Clinical Center for Asbestosis

Cochrane evidence based reviews: asbestosis

Genetic Tests for Asbestosis

Anatomical Context for Asbestosis

MalaCards organs/tissues related to Asbestosis:

40
Lung, Liver, Neutrophil, Lymph Node, Kidney, Bone Marrow, Heart

Publications for Asbestosis

Articles related to Asbestosis:

(show top 50) (show all 2308)
# Title Authors PMID Year
1
Glutathione S-transferases GSTM1 and GSTT1 polymorphisms and asbestosis. 54 61
17563610 2007
2
The glutathione S-transferase theta and mu deletion polymorphisms in asbestosis. 54 61
9055949 1997
3
Asbestos and Zeolites: from A to Z via a Common Ion. 61
33749247 2021
4
Imaging diagnosis of classical and new pneumoconiosis: predominant reticular HRCT pattern. 61
33689008 2021
5
Less Common Respiratory Conditions: Occupational Lung Diseases. 61
33683849 2021
6
[Update of the AWMF S2k Guideline "Diagnostics and Assessment of Occupational Asbestos-Related Diseases" - What's New?] 61
33728629 2021
7
Survival of patients with asbestosis can be assessed by risk-predicting models. 61
33637623 2021
8
Inorganic Fiber Lung Burden in Subjects with Occupational and/or Anthropogenic Environmental Asbestos Exposure in Broni (Pavia, Northern Italy): An SEM-EDS Study on Autoptic Samples. 61
33669843 2021
9
Exploration of identifying novel serum biomarkers for malignant mesothelioma using iTRAQ combined with 2D-LC-MS/MS. 61
33197421 2021
10
Asbestos in High-Risk Communities: Public Health Implications. 61
33562413 2021
11
Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation. 61
33567275 2021
12
Ongoing downplaying of the carcinogenicity of chrysotile asbestos by vested interests. 61
33622366 2021
13
The role of polymorphisms in glutathione-related genes in asbestos-related diseases. 61
33544514 2021
14
Sensitive Blood-Based Detection of Asbestos-Associated Diseases Using Cysteine-Rich Angiogenic Inducer 61 as Circulating Protein Biomarker. 61
33336248 2021
15
Incidence of Cancer and Asbestos-Related Diseases among Residents Living near Abandoned Asbestos Mines in South Korea: A Retrospective Cohort Study Using National Health Insurance Database. 61
33498425 2021
16
Costs of asbestosis and silicosis hospitalization in Italy (2001-2018) : Costs of asbestosis and silicosis hospitalization. 61
33404732 2021
17
Telomerase gene variants and telomere shortening in patients with silicosis or asbestosis. 61
33323453 2020
18
Follow-up of Soluble Mesothelin-Related Protein Levels in Participants With Asbestos-Related Disorders. 61
33329908 2020
19
Occupational Contributions to Interstitial Lung Disease. 61
33153688 2020
20
Monitoring of airborne asbestos fibers in an urban ambient air of Mashhad City, Iran: levels, spatial distribution and seasonal variations. 61
33312638 2020
21
Three-Year Study of Markers of Oxidative Stress in Exhaled Breath Condensate in Workers Producing Nanocomposites, Extended by Plasma and Urine Analysis in Last Two Years. 61
33291323 2020
22
Transplantation for work-related lung disease in the USA. 61
32859693 2020
23
[A case of asbestosis complicated with organizing pneumonia]. 61
33287487 2020
24
[A case of asbestosis complicated with adult onset Still's disease]. 61
33142387 2020
25
Imaging and imagination in the diagnostics of asbestosis. 61
33124613 2020
26
Cytological analysis of bronchoalveolar lavage fluid in asbestos-exposed workers. 61
33124609 2020
27
Increasing incidence of asbestosis worldwide, 1990-2017: results from the Global Burden of Disease study 2017. 61
32467338 2020
28
Association of occupational dust exposure with combined chronic obstructive pulmonary disease and pneumoconiosis: a cross-sectional study in China. 61
32907907 2020
29
[Asbestos exposure and related diseases among friction products workers (1971-2016)]. 61
33119974 2020
30
[The Amiantus Program in Poland - 20 years of implementation]. 61
32667289 2020
31
Mortality among U.S. military participants at eight aboveground nuclear weapons test series. 61
32602389 2020
32
Diagnosis of lung cancer: a necropsy-based study of 128 cases (1997-2016). 61
32811344 2020
33
A multidisciplinary approach for the diagnosis of benign asbestos pleural effusion: a single-center experience. 61
32944346 2020
34
Italian pool of asbestos workers cohorts: asbestos related mortality by industrial sector and cumulative exposure. 61
32959795 2020
35
A Case of Autoimmune Pulmonary Alveolar Proteinosis with Pulmonary Fibrosis and Asbestosis-Like Features. 61
32336733 2020
36
Factors Affecting Asbestosis Mortality Among Asbestos-Cement Workers in Italy. 61
32328661 2020
37
Asbestos-related diseases. 61
32553000 2020
38
Trends in Pneumoconiosis Deaths - United States, 1999-2018. 61
32525855 2020
39
Trends in global, regional and national incidence of pneumoconiosis caused by different aetiologies: an analysis from the Global Burden of Disease Study 2017. 61
32188634 2020
40
Asbestosis hospitalizations in Poland (2006-2016): results from the National Hospital Discharge Registry. 61
32588607 2020
41
[Sustainability in Outpatient Pulmonary Rehabilitation in Patients with Asbestosis - Results of an 8-Year Follow Up]. 61
32053838 2020
42
The Wittenoom legacy. 61
31670764 2020
43
The MUC5B promoter risk allele for idiopathic pulmonary fibrosis predisposes to asbestosis. 61
31949121 2020
44
Prognosis and causes of death of patients with acute exacerbation of fibrosing interstitial lung diseases. 61
32265195 2020
45
Familial Interstitial Lung Disease. 61
32279293 2020
46
[Diagnostic Challenges of Mixed Dust Silicosis (Mixed Dust Pneumoconiosis) - 5 Case Reports]. 61
32052391 2020
47
Talc and mesothelioma: mineral fiber analysis of 65 cases with clinicopathological correlation. 61
32183579 2020
48
Occupational cohort study of asbestos-cement workers in a contaminated site in Sicily (Italy). 61
32631013 2020
49
Malignant Diffuse Mesothelioma in Women: A Study of 354 Cases. 61
31876584 2020
50
Mortality and mesothelioma incidence among chrysotile asbestos miners in Balangero, Italy: A cohort study. 61
31821579 2020

Variations for Asbestosis

Expression for Asbestosis

Search GEO for disease gene expression data for Asbestosis.

Pathways for Asbestosis

GO Terms for Asbestosis

Cellular components related to Asbestosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 SOD3 SERPINA1 NLRP3 MUC1 MSLN MPO
2 extracellular space GO:0005615 9.28 THBD SOD3 SERPINA1 MUC1 MSLN MPO

Biological processes related to Asbestosis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.93 NOX4 NOS2 NLRP3 IL6 CHI3L1
2 aging GO:0007568 9.83 SOD2 OGG1 NOX4 MPO
3 response to hypoxia GO:0001666 9.8 SOD3 SOD2 NOX4 NOS2
4 negative regulation of apoptotic process GO:0043066 9.8 WT1 SOD2 OGG1 MPO IL6 GSTP1
5 response to lipopolysaccharide GO:0032496 9.78 THBD SOD2 NOS2 MPO
6 cellular oxidant detoxification GO:0098869 9.75 MPO GSTT1 GSTP1
7 cellular response to lipopolysaccharide GO:0071222 9.73 NOS2 NLRP3 IL6 GSTP1
8 response to oxidative stress GO:0006979 9.67 SOD3 SOD2 OGG1 MPO
9 glutathione metabolic process GO:0006749 9.63 GSTT1 GSTP1 GSTM1
10 hepoxilin biosynthetic process GO:0051122 9.57 GSTP1 GSTM1
11 negative regulation of acute inflammatory response GO:0002674 9.56 NLRP3 GSTP1
12 cellular response to oxidative stress GO:0034599 9.56 SOD3 SOD2 NOX4 GSTP1
13 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.55 NLRP3 IL6
14 interleukin-8 production GO:0032637 9.51 NOS2 CHI3L1
15 response to L-ascorbic acid GO:0033591 9.4 SOD2 GSTP1
16 glutathione derivative biosynthetic process GO:1901687 9.33 GSTT1 GSTP1 GSTM1
17 removal of superoxide radicals GO:0019430 9.13 SOD3 SOD2 MPO
18 superoxide metabolic process GO:0006801 8.92 SOD3 SOD2 NOX4 NOS2

Molecular functions related to Asbestosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.23 WT1 THBD SOD3 SOD2 SERPINA1 OGG1
2 glutathione binding GO:0043295 9.16 GSTP1 GSTM1
3 superoxide dismutase activity GO:0004784 8.96 SOD3 SOD2
4 glutathione transferase activity GO:0004364 8.8 GSTT1 GSTP1 GSTM1

Sources for Asbestosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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