MCID: ASB001
MIFTS: 47

Asbestosis

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Asbestosis

MalaCards integrated aliases for Asbestosis:

Name: Asbestosis 12 74 52 54 43 15 17 71
Idiopathic Interstitial Pneumonitis - from Asbestos Exposure 52
Pulmonary Fibrosis - from Asbestos Exposure 52

Classifications:



External Ids:

Disease Ontology 12 DOID:10320
ICD9CM 34 501
MeSH 43 D001195
NCIt 49 C84573
SNOMED-CT 67 22607003
ICD10 32 J61
UMLS 71 C0003949

Summaries for Asbestosis

Disease Ontology : 12 A pneumoconiosis caused by inhalation and retention of asbestos fibers.

MalaCards based summary : Asbestosis, also known as idiopathic interstitial pneumonitis - from asbestos exposure, is related to benign mesothelioma and pleural disease. An important gene associated with Asbestosis is GSTM1 (Glutathione S-Transferase Mu 1), and among its related pathways/superpathways are Innate Immune System and Pathways in cancer. The drugs Artichoke and Nintedanib have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and testes, and related phenotypes are cellular and mortality/aging

Wikipedia : 74 Asbestosis is long term inflammation and scarring of the lungs due to asbestos fibers. Symptoms may... more...

Related Diseases for Asbestosis

Diseases related to Asbestosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)
# Related Disease Score Top Affiliating Genes
1 benign mesothelioma 31.7 WT1 THBD CALB2
2 pleural disease 31.3 MSLN IL6 CALB2
3 peritoneal mesothelioma 30.8 WT1 THBD MUC1 CALB2
4 lung disease 30.8 SOD3 SERPINA1 MUC1 MPO IL6
5 pleural cancer 30.6 WT1 MSLN CALB2
6 bronchitis 30.6 SERPINA1 MPO IL6 GSTM1 CAT
7 pneumoconiosis 30.5 SERPINA1 OGG1 NLRP3 IL6 GSTM1 CAT
8 pulmonary fibrosis, idiopathic 30.5 THBD SERPINA1 MUC1 IL6 CHI3L1
9 malignant pleural mesothelioma 30.4 WT1 THBD MUC1 MSLN CALB2
10 pneumonia 30.3 SERPINA1 MUC1 MPO IL6
11 carcinosarcoma 30.3 WT1 MUC1 CALB2
12 pneumothorax 30.3 SERPINA1 MUC1 CALB2
13 mesothelioma, malignant 30.2 WT1 THBD SOD2 MUC1 MSLN CALB2
14 extrinsic allergic alveolitis 30.2 SOD2 MPO IL6
15 malignant biphasic mesothelioma 30.0 WT1 THBD MSLN CALB2
16 respiratory failure 30.0 THBD SERPINA1 MPO IL6 CAT
17 mycobacterium abscessus 29.9 SERPINA1 NLRP3
18 vasculitis 29.8 THBD SERPINA1 MPO IL6
19 pulmonary disease, chronic obstructive 29.5 SOD3 SERPINA1 MPO IL6 GSTP1 GSTM1
20 vascular disease 29.2 THBD NOS2 MPO IL6 CAT
21 lung cancer susceptibility 3 28.3 THBD SOD2 SERPINA1 OGG1 MUC1 MSLN
22 asbestos intoxication 12.0
23 anthracosis 11.7
24 interstitial lung disease 11.6
25 silicosis 10.8
26 pulmonary fibrosis 10.7
27 lung cancer 10.6
28 fallopian tube carcinosarcoma 10.5 WT1 CALB2
29 spindle cell thymoma 10.5 MUC1 CALB2
30 fibrosis of extraocular muscles, congenital, 1 10.5
31 mucinous cystadenofibroma 10.5 SERPINA1 MUC1
32 epididymal neoplasm 10.4 WT1 CALB2
33 malignant epithelial mesothelioma 10.4 THBD CALB2
34 wolffian duct adenocarcinoma 10.4 WT1 CALB2
35 hearing loss, noise-induced 10.4 GSTT1 GSTM1
36 colorectal cancer 8 10.4 GSTT1 GSTM1
37 testicular fibroma 10.4 WT1 CALB2
38 sister chromatid exchange, frequency of 10.4 GSTT1 GSTM1
39 pericardium cancer 10.4 WT1 MSLN CALB2
40 peritoneum cancer 10.4 WT1 MSLN CALB2
41 juvenile type testicular granulosa cell tumor 10.4 WT1 CALB2
42 ovarian mixed germ cell neoplasm 10.4 WT1 SERPINA1
43 lymphohistiocytoid mesothelioma 10.4 THBD CALB2
44 testicular granulosa cell tumor 10.4 WT1 CALB2
45 liver leiomyosarcoma 10.4 WT1 CALB2
46 ovarian endometrioid stromal sarcoma 10.4 WT1 CALB2
47 anca-associated vasculitis 10.4 SERPINA1 MPO
48 ovarian gonadoblastoma 10.4 WT1 CALB2
49 pericardial mesothelioma 10.4 MUC1 CALB2
50 cystadenofibroma 10.4 WT1 MUC1 CALB2

Comorbidity relations with Asbestosis via Phenotypic Disease Network (PDN):


Bronchitis Chronic Pulmonary Heart Disease
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Intermediate Coronary Syndrome
Postinflammatory Pulmonary Fibrosis Prostate Cancer
Prostatic Hypertrophy Respiratory Failure

Graphical network of the top 20 diseases related to Asbestosis:



Diseases related to Asbestosis

Symptoms & Phenotypes for Asbestosis

MGI Mouse Phenotypes related to Asbestosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.06 CAT CHI3L1 IL6 KIF18A KIF5A NLRP3
2 mortality/aging MP:0010768 9.97 CAT IL6 KIF18A KIF5A MPO NLRP3
3 liver/biliary system MP:0005370 9.8 IL6 NLRP3 NOS2 OGG1 SOD2 THBD
4 neoplasm MP:0002006 9.5 CAT GSTP1 IL6 NOS2 OGG1 SOD2
5 normal MP:0002873 9.28 CALB2 KIF5A MSLN NLRP3 OGG1 SERPINA1

Drugs & Therapeutics for Asbestosis

Drugs for Asbestosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Artichoke Approved Phase 2
2
Nintedanib Approved Phase 2 656247-17-5 56843413
3 Xenon Experimental Early Phase 1 7440-63-3
4 Respiratory System Agents

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Comparison of the Ultra-low-dose Veo Algorithm With the Gold Standard Filtered Back Projection for Detecting Pulmonary Asbestos-related Conditions Completed NCT01955018 Phase 4
2 Utility of Lung Clearance Index Score as a Noninvasive Marker of Small Airways Disease Recruiting NCT03241420 Phase 3
3 Investigation of the Anti-Cancer Activity of Artichoke Extract in an Asbestos-Exposed Population (The ABOCA Phase II Trial) Recruiting NCT02076672 Phase 2 Artichoke WPC
4 The Nintedanib in Progressive Pneumoconiosis Study (NiPPS): a Collaborative NSW Treatment Trial Not yet recruiting NCT04161014 Phase 2 Nintedanib 150 MG [Ofev]
5 OSCILLATION MECHANICS OF THE RESPIRATORY SYSTEM ASBESTOS EXPOSED : Early Diagnosis Unknown status NCT02280343
6 Idiopathic Pulmonary Fibrosis Job Exposures Study Completed NCT03211507
7 Linkage Study in Familial Pulmonary Fibrosis Completed NCT00016627
8 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
9 Molecular Epidemiology of Acute Respiratory Distress Syndrome Recruiting NCT00006496
10 The Edinburgh Lung Fibrosis Molecular Endotyping (ELFMEN) Study Enrolling by invitation NCT04016181
11 Developing Optimal Parameters for Hyperpolarized Noble Gas (3He and 129Xe) and Inert Fluorinated Gas Magnetic Resonance Imaging of Lung Disorders Not yet recruiting NCT02748798 Early Phase 1 HP 3He;HP 129Xe;PFP;SF6
12 It's Not JUST Idiopathic Pulmonary Fibrosis Study Suspended NCT03670576

Search NIH Clinical Center for Asbestosis

Cochrane evidence based reviews: asbestosis

Genetic Tests for Asbestosis

Anatomical Context for Asbestosis

MalaCards organs/tissues related to Asbestosis:

40
Lung, Heart, Testes, Neutrophil, Lymph Node, T Cells, Nk Cells

Publications for Asbestosis

Articles related to Asbestosis:

(show top 50) (show all 2266)
# Title Authors PMID Year
1
Glutathione S-transferases GSTM1 and GSTT1 polymorphisms and asbestosis. 61 54
17563610 2007
2
The glutathione S-transferase theta and mu deletion polymorphisms in asbestosis. 54 61
9055949 1997
3
Asbestos-related diseases. 61
32553000 2020
4
Trends in Pneumoconiosis Deaths - United States, 1999-2018. 61
32525855 2020
5
Trends in global, regional and national incidence of pneumoconiosis caused by different aetiologies: an analysis from the Global Burden of Disease Study 2017. 61
32188634 2020
6
Increasing incidence of asbestosis worldwide, 1990-2017: results from the Global Burden of Disease study 2017. 61
32467338 2020
7
Familial Interstitial Lung Disease. 61
32279293 2020
8
[Sustainability in Outpatient Pulmonary Rehabilitation in Patients with Asbestosis - Results of an 8-Year Follow Up]. 61
32053838 2020
9
Factors Affecting Asbestosis Mortality Among Asbestos-Cement Workers in Italy. 61
32328661 2020
10
Prognosis and causes of death of patients with acute exacerbation of fibrosing interstitial lung diseases. 61
32265195 2020
11
A Case of Autoimmune Pulmonary Alveolar Proteinosis with Pulmonary Fibrosis and Asbestosis-Like Features. 61
32336733 2020
12
The MUC5B promoter risk allele for idiopathic pulmonary fibrosis predisposes to asbestosis. 61
31949121 2020
13
The Wittenoom legacy. 61
31670764 2020
14
Malignant Diffuse Mesothelioma in Women: A Study of 354 Cases. 61
31876584 2020
15
Talc and mesothelioma: mineral fiber analysis of 65 cases with clinicopathological correlation. 61
32183579 2020
16
[Diagnostic Challenges of Mixed Dust Silicosis (Mixed Dust Pneumoconiosis) - 5 Case Reports]. 61
32052391 2020
17
Mortality and mesothelioma incidence among chrysotile asbestos miners in Balangero, Italy: A cohort study. 61
31821579 2020
18
[Diffuse Intraparenchymal Mesothelioma: An Atypical Presentation]. 61
32035500 2020
19
A case of hypersensitivity pneumonitis in a worker exposed to terephthalic acid in the production of polyethylene terephthalate. 61
31691678 2020
20
Occurrence, behaviour, and human exposure pathways and health risks of toxic geogenic contaminants in serpentinitic ultramafic geological environments (SUGEs): A medical geology perspective. 61
31693951 2020
21
[About the asbestos and the Position Paper on asbestos of the Italian Society of Occupational Medicine]. 61
32374117 2020
22
Analytical transmission electron microscopy of amosite asbestos from South Africa. 61
30702033 2020
23
Global use of asbestos - legitimate and illegitimate issues. 61
32549902 2020
24
Pleural Plaques and the Risk of Lung Cancer in Asbestos-exposed Subjects. 61
31433952 2020
25
NLRP3 and CARD8 polymorphisms influence risk for asbestos-related diseases. 61
32549782 2020
26
Follow-Up of the Libby, Montana Screening Cohort: A 17-Year Mortality Study. 61
31714372 2020
27
[The occurrence of asbestos-related diseases among former employees of asbestos processing plants in Poland]. 61
31682242 2019
28
Position Paper on Asbestos of the Italian Society of Occupational Medicine. 61
31846450 2019
29
Asbestos, Smoking and Lung Cancer: An Update. 61
31905913 2019
30
[Incidence and yrend of occupational pneumoconiosis in Ankang city from 1974 to 2017]. 61
31937033 2019
31
[Idiopathic pleuroparenehymal fibroelastosis: report of one case and review of literature]. 61
31694096 2019
32
Relationship between pleural plaques and biomarkers of cumulative asbestos dose. A necropsy study. 61
31659992 2019
33
Bronchoalveolar cell differential count and the number of asbestos bodies correlate with survival in patients with asbestosis. 61
31331950 2019
34
Pneumatosis intestinalis and pneumoretroperitoneum post steroid use in a patient with superior mesenteric artery syndrome. 61
31262624 2019
35
Asbestosis and silicosis hospitalizations in Italy (2001-2015): results from the National Hospital Discharge Registry. 61
30753424 2019
36
Mortality of older construction and craft workers employed at department of energy nuclear sites: Follow-up through 2016. 61
31380577 2019
37
On the diagnosis of malignant pleural mesothelioma: A necropsy-based study of 171 cases (1997-2016). 61
29714657 2019
38
Cumulative asbestos exposure and mortality from asbestos related diseases in a pooled analysis of 21 asbestos cement cohorts in Italy. 61
31391078 2019
39
In vivo probe-based confocal laser endomicroscopy in chronic interstitial lung diseases: Specific descriptors and correlation with chest CT. 61
30811085 2019
40
NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis. 61
31434799 2019
41
[Asbestos and its effects on health of Icelanders - review]. 61
31411568 2019
42
Mesothelioma mortality within two radiation monitored occupational cohorts. 61
31290725 2019
43
The natural course of lung function decline in asbestos exposed subjects with pleural plaques and asbestosis. 61
31226624 2019
44
Synthetic secoisolariciresinol diglucoside (LGM2605) inhibits Libby amphibole fiber-induced acute inflammation in mice. 61
31022494 2019
45
Oxidative effects of lungs in Wistar rats caused by long-term exposure to four kinds of China representative chrysotile. 61
31055741 2019
46
High frequency and severity of pleural changes in former workers exposed to anthophyllite associated with other contaminating amphibole asbestos in Brazil. 61
31046142 2019
47
Monitoring of airborne asbestos fibers in an urban ambient air of Shahryar City, Iran: levels, spatial distribution, seasonal variations, and health risk assessment. 61
30623323 2019
48
Imaging in idiopathic pulmonary fibrosis: diagnosis and mimics. 61
30726312 2019
49
Protocol for identification of airborne asbestos fibres in the urban areas and spatio-temporal trend. 61
31667124 2019
50
Analyzing biological and molecular characteristics and genomic damage induced by exposure to asbestos. 61
31239765 2019

Variations for Asbestosis

Expression for Asbestosis

Search GEO for disease gene expression data for Asbestosis.

Pathways for Asbestosis

GO Terms for Asbestosis

Cellular components related to Asbestosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.1 WT1 SOD3 NOS2 NLRP3 MUC1 MPO
2 extracellular exosome GO:0070062 9.81 SOD3 SOD2 SERPINA1 MUC1 MPO GSTT1
3 extracellular region GO:0005576 9.65 SOD3 SERPINA1 NLRP3 MUC1 MSLN MPO
4 extracellular space GO:0005615 9.32 THBD SOD3 SERPINA1 MUC1 MSLN MPO

Biological processes related to Asbestosis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.95 SERPINA1 MPO GSTP1 CHI3L1 CAT
2 negative regulation of apoptotic process GO:0043066 9.85 WT1 OGG1 MPO IL6 GSTP1 CAT
3 cellular response to lipopolysaccharide GO:0071222 9.8 NOS2 NLRP3 IL6 GSTP1
4 response to oxidative stress GO:0006979 9.71 SOD3 OGG1 MPO CAT
5 glutathione metabolic process GO:0006749 9.65 GSTT1 GSTP1 GSTM1
6 cellular response to oxidative stress GO:0034599 9.62 SOD3 SOD2 GSTP1 CAT
7 hepoxilin biosynthetic process GO:0051122 9.54 GSTP1 GSTM1
8 negative regulation of acute inflammatory response GO:0002674 9.52 NLRP3 GSTP1
9 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.51 NLRP3 IL6
10 interleukin-8 secretion GO:0072606 9.46 NOS2 CHI3L1
11 response to L-ascorbic acid GO:0033591 9.43 GSTP1 CAT
12 superoxide metabolic process GO:0006801 9.43 SOD3 SOD2 NOS2
13 glutathione derivative biosynthetic process GO:1901687 9.33 GSTT1 GSTP1 GSTM1
14 cellular oxidant detoxification GO:0098869 9.26 MPO GSTT1 GSTP1 CAT
15 removal of superoxide radicals GO:0019430 8.8 SOD3 SOD2 MPO

Molecular functions related to Asbestosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione binding GO:0043295 9.16 GSTP1 GSTM1
2 superoxide dismutase activity GO:0004784 8.96 SOD3 SOD2
3 glutathione transferase activity GO:0004364 8.8 GSTT1 GSTP1 GSTM1

Sources for Asbestosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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