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MCID: ASC001
MIFTS: 38

Ascaridiasis

Categories: Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Ascaridiasis

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MalaCards integrated aliases for Ascaridiasis:

Name: Ascaridiasis 12 45 15 17 74
Ascariasis 74

Classifications:

MalaCards categories:
Global: Infectious diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3108
MeSH 45 D001198
SNOMED-CT 69 2435008 76160002
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Summaries for Ascaridiasis

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Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the intestine of humans and birds with nematodes of the genus Ascaridia.

MalaCards based summary : Ascaridiasis, also known as ascariasis, is related to dysbaric osteonecrosis and conjunctival disease. An important gene associated with Ascaridiasis is STIMATE (STIM Activating Enhancer), and among its related pathways/superpathways are Th17 cell differentiation and Glucocorticoid receptor regulatory network. The drugs Albendazole and Pyrantel have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and testes, and related phenotype is endocrine/exocrine gland.

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Related Diseases for Ascaridiasis

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Diseases related to Ascaridiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 dysbaric osteonecrosis 10.2 PLG STH
2 conjunctival disease 10.2 IL13 PLG
3 filarial elephantiasis 10.2 IL10 STH
4 nickel allergic contact dermatitis 10.2 IL10 IL13
5 apple allergy 10.2 IL10 IL13
6 beta-lactam allergy 10.2 IL10 IL13
7 eosinophilic meningitis 10.1 IL10 IL13
8 peanut allergy 10.1 IL10 IL13
9 mycoplasma pneumoniae pneumonia 10.1 IL10 IL13
10 radiculopathy 10.1 IL10 IL13
11 lipoid nephrosis 10.1 IL10 IL13
12 paranasal sinus disease 10.1 IL10 IL13
13 conjunctivitis 10.1 IL13 PLG
14 nasal cavity disease 10.1 IL10 IL13
15 nose disease 10.1 IL10 IL13
16 intestinal perforation 10.1
17 vasculitis 10.1
18 cholangitis 10.1
19 respiratory allergy 10.1 IL10 IL13
20 hyperlucent lung 10.1 IL10 NELFCD
21 pericardial tuberculosis 10.1 IL10 NELFCD
22 ige responsiveness, atopic 10.1 IL10 IL13
23 buruli ulcer 10.1 IL10 NELFCD
24 food allergy 10.1 IL10 IL13
25 upper respiratory tract disease 10.1 IL10 IL13
26 transient hypogammaglobulinemia of infancy 10.1 IL10 NELFCD
27 cutaneous leishmaniasis 10.1 IL10 IL13
28 hepatic vascular disease 10.0 AFP PLG
29 leishmaniasis 10.0 IL10 IL13
30 immune deficiency disease 10.0 IL10 IL13
31 vein disease 10.0 AFP PLG
32 bronchial disease 10.0 IL10 IL13
33 schistosomiasis 10.0 IL10 IL13
34 tracheal cancer 10.0 AFP NELFCD
35 testicular disease 10.0 AFP IL10
36 bronchiolitis 10.0 IL10 IL13
37 hepatitis a 10.0 AFP IL10
38 proteasome-associated autoinflammatory syndrome 1 10.0 IL10 IL13
39 trichuriasis 9.9 IL10 IL13 STH
40 parasitic helminthiasis infectious disease 9.9 IL10 IL13 STH
41 tetanus 9.9 IL10 IL13
42 allergic asthma 9.9 IL10 IL13
43 respiratory system disease 9.7 IL10 IL13

Graphical network of the top 20 diseases related to Ascaridiasis:



Diseases related to Ascaridiasis
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Symptoms & Phenotypes for Ascaridiasis

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MGI Mouse Phenotypes related to Ascaridiasis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.02 AFP IL10 IL13 PLG PPP3R1
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Drugs & Therapeutics for Ascaridiasis

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Drugs for Ascaridiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 4,Not Applicable 54965-21-8 2082
2
Pyrantel Approved, Vet_approved Phase 4 15686-83-6
3 Anthelmintics Phase 4,Not Applicable
4 Pyrantel Pamoate Phase 4
5 Anti-Infective Agents Phase 4,Not Applicable
6 Adjuvants, Immunologic Phase 4
7 Antiparasitic Agents Phase 4,Not Applicable
8 Immunologic Factors Phase 4
9 Antimitotic Agents Phase 4,Not Applicable
10 Antiprotozoal Agents Phase 4,Not Applicable
11 Antirheumatic Agents Phase 4
12
Ivermectin Approved, Investigational, Vet_approved Not Applicable 70288-86-7 6474909
13
Mebendazole Approved, Vet_approved Not Applicable 31431-39-7 4030
14
Iodine Approved, Investigational 7553-56-2 807
15
Vitamin C Approved, Nutraceutical Not Applicable 50-81-7 54670067 5785
16 Nutrients Not Applicable
17 Trace Elements Not Applicable
18 Vitamins Not Applicable
19 Antioxidants Not Applicable
20 Micronutrients Not Applicable
21 Protective Agents Not Applicable
22 cadexomer iodine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy Albendazole and Levamisole Against STH on Unguja Completed NCT00659997 Phase 4 Albendazole;Levamisole
2 The Impact of Anthelmintic Treatment on the Incidence of Diarrheal Disease in Vietnamese School Children Withdrawn NCT02597556 Phase 4 Albendazole;Placebo
3 Impact of Repeated Anthelmintic Treatment on the Risk of Malaria in Kenyan School Children Completed NCT01658774 Not Applicable Albendazole
4 Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm Infections Completed NCT00207753 Not Applicable albendazole vs. combined albendazole/ivermectin treatment
5 The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989 Not Applicable
6 Intestinal Parasites in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435

Search NIH Clinical Center for Ascaridiasis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: ascaridiasis

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Genetic Tests for Ascaridiasis

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Anatomical Context for Ascaridiasis

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MalaCards organs/tissues related to Ascaridiasis:

42
Liver, Lung, Testes, Kidney, Colon, Eye, Small Intestine
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Publications for Ascaridiasis

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Articles related to Ascaridiasis:

(show top 50) (show all 813)
# Title Authors Year
1
Biliary Ascariasis Mimicking as Choledocholithiasis on Endoscopic Ultrasound. ( 30935184 )
2019
2
Biliary Ascariasis: An Unusual Case of Obstructive Jaundice. ( 30710698 )
2019
3
Efficacy of Albendazole and Mebendazole With or Without Levamisole for Ascariasis and Trichuriasis. ( 31110573 )
2019
4
Incidental diagnosis of appendiceal ascariasis during colonoscopy. ( 30115571 )
2019
5
Ascariasis as a model to study the helminth/allergy relationships. ( 30295330 )
2019
6
The inner tube sign in Ascariasis. ( 30498923 )
2019
7
Ascariasis and its relationship with selected psycho-neurological symptoms among children and adults in Poland. ( 31099762 )
2019
8
Recurrent acute pancreatitis due to pancreatic duct ascariasis in a young man. ( 30096718 )
2018
9
Successful Elimination of Gallbladder Ascariasis by Conservative Therapy, Followed by Cholecystectomy due to Developing Cholecystitis. ( 30643654 )
2018
10
Small bowel volvulus in an adult with mesenteric lymphangioma and ascariasis. ( 28266164 )
2018
11
Concomitant ascariasis as a factor in reducing the quality of life of patients with chronic pancreatitis. ( 30448792 )
2018
12
Ascariasis Diagnosed by Wireless Capsule Endoscopy. ( 28865763 )
2018
13
Ascariasis seen by videocapsule endoscopy. ( 29222943 )
2018
14
Gallbladder ascariasis in Kosovo - focus on ultrasound and conservative therapy: a case series. ( 29329599 )
2018
15
A Worm Hole: Liver Abscess in Ascariasis. ( 29518367 )
2018
16
EUS of pancreatic ascariasis. ( 29523472 )
2018
17
Biliary ascariasis presenting with gangrenous perforation of the gall bladder: report of a case and brief review of literature. ( 29649951 )
2018
18
Gastrointestinal: An unusual cause of biliary colic: Biliary ascariasis. ( 29659086 )
2018
19
High prevalence of ascariasis on two coral atolls in the Solomon Islands. ( 29800343 )
2018
20
Differential diagnosis of gallbladder ascariasis debris: the added value of contrast enhanced ultrasound with high frequency transducer. ( 30534646 )
2018
21
Ascariasis and pancreatitis. ( 28937027 )
2017
22
Ascaris lumbricoides through pleural biopsy needle. A rare case of intrapleural ascariasis. ( 27823891 )
2017
23
Intestinal ascariasis detected by double-balloon enteroscopy. ( 28066936 )
2017
24
Ascariasis and hyperosmolar hyperglycemic state: a surprising ultrasound finding in the emergency department. ( 28324468 )
2017
25
Combination of laparoscope and choledochoscope to treat biliary ascariasis: A CARE-compliant case report. ( 28353561 )
2017
26
Post Extubation Bronchospasm in an Undiagnosed Case of Ascariasis: Anaesthetic Challenges. ( 28384964 )
2017
27
Ascariasis imaging: pictorial essay. ( 28499324 )
2017
28
Hematuria from urinary ascariasis. ( 28501309 )
2017
29
Endoscopic ultrasound of bile duct ascariasis (with video). ( 28621300 )
2017
30
Hygienic Behaviors and Risks for Ascariasis among College Students in Kabul, Afghanistan. ( 28829737 )
2017
31
You Traveled the World and All You Got Was Ascariasis. ( 29056213 )
2017
32
A multilevel study of the environmental determinants of swine ascariasis in England. ( 29157367 )
2017
33
A Case of Biliary Ascariasis in Korea. ( 29320821 )
2017
34
Biliary ascariasis: mimicker of biliary stent. ( 29905283 )
2017
35
Acute pancreatitis due to ascariasis: a sonographic pictorial essay on four cases. ( 27059341 )
2016
36
A rare cause of dysphagia: pharyngeal ascariasis. ( 27876959 )
2016
37
OVERDIAGNOSIS OF COELIAC DISEASE IN A PATIENT WITH ASCARIASIS AND GIARDIASIS. ( 29889407 )
2016
38
Respiratory Failure Associated with Ascariasis in a Patient with Immunodeficiency. ( 27313919 )
2016
39
Pancreatic duct ascariasis. ( 26348548 )
2016
40
Hepatobiliary and pancreatic ascariasis-sonographic pictorial essay on four pediatric cases with acute biliary colic. ( 26690772 )
2016
41
Endoscopic ultrasound of pancreatic duct ascariasis. ( 26822523 )
2016
42
Endoscopic ultrasound imaging of pancreatic duct ascariasis. ( 26829193 )
2016
43
Intrahepatic Duct Stones Harboring Ascariasis Ova: A Case Report. ( 27015193 )
2016
44
A Co-Presentation of Biliary Ascariasis and Hepatic Hydatidosis. ( 27042559 )
2016
45
Biliary ascariasis as etiology of recurrent abdominal pain. ( 27285651 )
2016
46
Hepatobiliary and pancreatic ascariasis. ( 27672273 )
2016
47
A Social History of Ascariasis in the 1960s Korea : From a Norm to a Shameful Disease. ( 27679467 )
2016
48
Esophageal Ascariasis with Retrosternal Chest Discomfort. ( 27731572 )
2016
49
Biliary Ascariasis Diagnosed and Extracted by ERCP in the United States. ( 28119939 )
2016
50
Idiopathic Acute Pancreatitis: Role of EUS With Reference to Biliary and Pancreatic Ascariasis. ( 26348307 )
2015
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Variations for Ascaridiasis

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Expression for Ascaridiasis

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Search GEO for disease gene expression data for Ascaridiasis.
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Pathways for Ascaridiasis

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Pathways related to Ascaridiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Th17 cell differentiation 38
Show member pathways
 12.08 IL10 IL13 PPP3R1
2
Glucocorticoid receptor regulatory network 1
11.39 AFP IL13
3
Innate Lymphoid Cell Differentiation Pathways 66
11.36 IL10 IL13
4
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.28 IL10 IL13
5
Staphylococcus aureus infection 38
11.24 IL10 PLG
6
Interleukin-10 signaling 67
11.01 IL10 IL13
7
Th2 Differentiation Pathway 66
10.92 IL10 IL13
8
Initiation of transcription and translation elongation at the HIV-1 LTR 1
10.72 NELFCD PPP3R1
9
Cytokines and Inflammatory Response 1
10.42 IL10 IL13
10
OX40 Pathway 65
10.04 IL10 IL13
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GO Terms for Ascaridiasis

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Biological processes related to Ascaridiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of endothelial cell apoptotic process GO:2000352 8.96 IL10 IL13
2 positive regulation of macrophage activation GO:0043032 8.62 IL10 IL13
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Sources for Ascaridiasis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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