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MCID: ASC001
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Ascaridiasis

Categories: Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Ascaridiasis

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MalaCards integrated aliases for Ascaridiasis:

Name: Ascaridiasis 12 43 15 17 71
Ascariasis 71

Classifications:

MalaCards categories:
Global: Infectious diseases
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External Ids:

Disease Ontology 12 DOID:3108
MeSH 43 D001198
SNOMED-CT 67 2435008 76160002
UMLS 71 C0003950 C0003952
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Summaries for Ascaridiasis

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Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the intestine of humans and birds with nematodes of the genus Ascaridia.

MalaCards based summary : Ascaridiasis, also known as ascariasis, is related to ascaris lumbricoides infection and enterobiasis. An important gene associated with Ascaridiasis is STIMATE (STIM Activating Enhancer), and among its related pathways/superpathways are Signaling by Rho GTPases and p75 NTR receptor-mediated signalling. The drugs Pyrantel and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and lung.

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Related Diseases for Ascaridiasis

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Diseases related to Ascaridiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 ascaris lumbricoides infection 10.4
2 enterobiasis 10.3
3 parasitic helminthiasis infectious disease 10.3
4 ancylostomiasis 10.3
5 cholangitis 10.3
6 diarrhea 10.2
7 obstructive jaundice 10.2
8 cholecystitis 10.2
9 necatoriasis 10.2
10 acute pancreatitis 10.2
11 pancreatitis 10.2
12 peritonitis 10.2
13 intestinal obstruction 10.2
14 hypereosinophilic syndrome 10.2
15 hydrops, lactic acidosis, and sideroblastic anemia 10.0
16 taeniasis 10.0
17 thrombosis 10.0
18 filariasis 10.0
19 capillariasis 10.0
20 trichuriasis 10.0
21 trichostrongylosis 10.0
22 lymphadenitis 10.0
23 intestinal perforation 10.0
24 parasitic protozoa infectious disease 10.0
25 cryoglobulinemia 10.0
26 linitis plastica 10.0
27 elephantiasis 10.0
28 intestinal disease 10.0
29 appendicitis 10.0
30 vasculitis 10.0
31 toxocariasis 10.0
32 toxic megacolon 8.2 RND2 RHOV RHOF RHOBTB1 RAC3
33 cardiomyopathy, familial hypertrophic, 1 8.1 RND2 RHOV RHOF RHOBTB1 RAC3

Graphical network of the top 20 diseases related to Ascaridiasis:



Diseases related to Ascaridiasis
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Symptoms & Phenotypes for Ascaridiasis

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Drugs & Therapeutics for Ascaridiasis

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Drugs for Ascaridiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pyrantel Approved, Vet_approved Phase 4 15686-83-6
2 Immunologic Factors Phase 4
3 Adjuvants, Immunologic Phase 4
4 Pyrantel Pamoate Phase 4
5 Antirheumatic Agents Phase 4
6
Ivermectin Approved, Investigational, Vet_approved 70288-86-7 6474909
7
Mebendazole Approved, Vet_approved 31431-39-7 4030
8
Iodine Approved, Investigational 7553-56-2 807
9
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067
10 Trace Elements
11 Vitamins
12 Nutrients
13 Micronutrients
14 Protective Agents
15 Antioxidants
16 Antibiotics, Antitubercular
17 Anti-Bacterial Agents
18 cadexomer iodine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Longitudinal Study of Efficacy of Standard Albendazole Treatment Versus Levamisole/Pyrantel Pamoate on Soil Transmitted Helminth Infections Completed NCT00659997 Phase 4 Albendazole;Levamisole
2 A Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Impact of Anthelmintic Treatment on the Incidence of Diarrheal Disease in School Children in Southern Vietnam Withdrawn NCT02597556 Phase 4 Albendazole;Placebo
3 Efficacy and Nutritional Assessment Following Albendazole and Combined Albendazole/Ivermectin Treatment for Intestinal Helminth Infections in Rural Guatemalan Schoolchildren Completed NCT00207753 albendazole vs. combined albendazole/ivermectin treatment
4 Impact of Repeated Anthelminthic Treatment on Malaria in School Children: an Individual Randomized, Double-blind, Placebo-controlled Trial in Western Kenya Completed NCT01658774 Albendazole
5 The Sero-prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989
6 Paediatric Surgery Across Sub-Saharan Africa: A Multi-Centre Prospective Cohort Study Completed NCT03185637
7 Diagnostics of Intestinal Parasitosis in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435

Search NIH Clinical Center for Ascaridiasis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Ivermectin
Mebendazole
Pyrantel
Pyrantel Pamoate

Cochrane evidence based reviews: ascaridiasis

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Genetic Tests for Ascaridiasis

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Anatomical Context for Ascaridiasis

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MalaCards organs/tissues related to Ascaridiasis:

40
Liver, Testes, Lung, Small Intestine, Kidney, Skin, Eye
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Publications for Ascaridiasis

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Articles related to Ascaridiasis:

(show top 50) (show all 2307)
# Title Authors PMID Year
1
Exposure to Ascaris lumbricoides infection and risk of childhood asthma in north of Iran. 61
31350726 2019
2
Comorbidity associated to Ascaris suum infection during pulmonary fibrosis exacerbates chronic lung and liver inflammation and dysfunction but not affect the parasite cycle in mice. 61
31765381 2019
3
The role of the liver in the migration of parasites of global significance. 61
31703729 2019
4
Epidemiology of Parasitic Infections in the West Bank and Gaza Strip, Palestine. 61
31769396 2019
5
BioStruct-Africa: empowering Africa-based scientists through structural biology knowledge transfer and mentoring - recent advances and future perspectives. 61
31490179 2019
6
Ascariasis Causing Biliary Colic. 61
31750371 2019
7
Parasitic infections in Malaysian aborigines with pulmonary tuberculosis: a comparative cross-sectional study. 61
31363922 2019
8
Anti-Ascaris suum immunoglobulin Y as a novel biotechnological tool for the diagnosis of human ascariasis. 61
31409433 2019
9
The liver proteome in a mouse model for Ascaris suum resistance and susceptibility: evidence for an altered innate immune response. 61
31412915 2019
10
Rare presentation of haemobilia and Loeffler's pneumonia in a child by ascaris lumbricoides. 61
31466983 2019
11
Differential diagnosis of focal gallbladder lesions: The added value of contrast enhanced ultrasound with liner transducers. 61
31306115 2019
12
Gallbladder Perforation Due to Ascaris lumbricoides in a Pregnant Woman and 6 Year Old Girl from Afghanistan: Case Report. 61
31673268 2019
13
Old Antiprotozoal Drugs: Are They Still Viable Options for Parasitic Diseases or New Options for Other Diseases? 61
31264538 2019
14
Ascariasis as a model to study the helminth/allergy relationships. 61
30295330 2019
15
In vitro and in vivoAreca catechu crude aqueous extract as an anthelmintic against Ascaridia galli infection in chickens. 61
31440008 2019
16
Small bowel obstruction complicating an Ascaris lumbricoides infestation in a 4-year-old male: a case report. 61
31122293 2019
17
Dual Parasitization of the Biliary Tree: First Reported Case. 61
31616753 2019
18
Secular Trends of Ascariasis Infestation and Nutritional Status in Chinese Children From 2000 to 2014: Evidence From 4 Successive National Surveys. 61
31139673 2019
19
Biological role of excretory-secretory proteins in endemic parasites of Latin America and the Caribbean. 61
31092301 2019
20
[Interpretation of Diagnosis of Ascariasis (WS/565-2017)]. 61
31184060 2019
21
Efficacy of Albendazole and Mebendazole With or Without Levamisole for Ascariasis and Trichuriasis. 61
31110573 2019
22
Ascariasis and its relationship with selected psycho-neurological symptoms among children and adults in Poland. 61
31099762 2019
23
The inner tube sign in Ascariasis. 61
30498923 2019
24
Imaging of toxocariasis. 61
30861557 2019
25
Ultrasonography for early diagnosis of Toxocara canis infection in puppies. 61
30706166 2019
26
Molecular analysis of human- and pig-derived Ascaris in Honduras. 61
29502555 2019
27
Comparative analysis of excretory-secretory antigens of Anisakis simplex, Pseudoterranova decipiens and Contracaecum osculatum regarding their applicability for specific serodiagnosis of human anisakidosis based on IgG-ELISA. 61
30584924 2019
28
Predictors of therapeutic failure among patients with acute brucellosis treated by dual therapy with doxycycline-rifampin. 61
30411836 2019
29
Ascariasis-associated perforated appendicitis: Computed tomography findings. 61
31650119 2019
30
Incidental diagnosis of appendiceal ascariasis during colonoscopy. 61
30115571 2019
31
Biliary Ascariasis: An Unusual Case of Obstructive Jaundice. 61
30710698 2019
32
Biliary Ascariasis Mimicking as Choledocholithiasis on Endoscopic Ultrasound. 61
30935184 2019
33
Homology modeling and molecular dynamics dimulation study of β carbonic anhydrase of Ascaris lumbricoides. 61
31719767 2019
34
Children from a rural region in The Chiapas Highlands, Mexico, show an increased risk of stunting and intestinal parasitoses when compared with urban children. 61
30657470 2019
35
Never seen before? Opisthorchiasis and Clonorchiasis. 61
30466135 2018
36
Small bowel volvulus in an adult with mesenteric lymphangioma and ascariasis. 61
28266164 2018
37
Ascaris lumbricoides: challenges in diagnosis, treatment and prevention strategies in a European refugee camp. 61
29458300 2018
38
Differential diagnosis of gallbladder ascariasis debris: the added value of contrast enhanced ultrasound with high frequency transducer. 61
30534646 2018
39
Ascaris Larval Infection and Lung Invasion Directly Induce Severe Allergic Airway Disease in Mice. 61
30249744 2018
40
Ascaris lumbricoides infection induces both, reduction and increase of asthma symptoms in a rural community. 61
30040946 2018
41
An unusual finding of obstructive jaundice-a case report and review of the literature. 61
30323942 2018
42
Association of intestinal pathogens with faecal markers of environmental enteric dysfunction among slum-dwelling children in the first 2 years of life in Bangladesh. 61
30133067 2018
43
Worm Infestation: Diagnosis, Treatment and Prevention. 61
29127616 2018
44
Recurrent acute pancreatitis due to pancreatic duct ascariasis in a young man. 61
30096718 2018
45
A Worm Hole: Liver Abscess in Ascariasis. 61
29518367 2018
46
Parasite allergens. 61
29588070 2018
47
Molecular identification of Ascaris lumbricoides and Ascaris suum recovered from humans and pigs in Thailand, Lao PDR, and Myanmar. 61
29860571 2018
48
Epidemiology of soil transmitted Helminth infections in the middle-belt of Ghana, Africa. 61
29988303 2018
49
Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-Specific Immune Changes. 61
29752313 2018
50
Ascaridial Volvulus: An Uncommon Cause of Ileal Perforation. 61
30046214 2018
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Variations for Ascaridiasis

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Expression for Ascaridiasis

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Search GEO for disease gene expression data for Ascaridiasis.
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Pathways for Ascaridiasis

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Pathways related to Ascaridiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Signaling by Rho GTPases 65
Show member pathways
 12.12 RHOV RHOF RHOBTB1 RAC3
2
p75 NTR receptor-mediated signalling 65
Show member pathways
 11.69 RHOV RHOF RHOBTB1 RAC3
3
Fc-GammaR Pathway 63
Show member pathways
 11.48 RND2 RAC3
4
S-1P Stimulated Signaling 63
11.39 RND2 RAC3
5
Guidance Cues and Growth Cone Motility 63
11.39 RND2 RAC3
6
Phagocytosis of Microbes 63
11.19 RND2 RAC3
7
Semaphorin Signaling 63
10.81 RND2 RAC3
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GO Terms for Ascaridiasis

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Cellular components related to Ascaridiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular GO:0005622 9.55 RND2 RHOV RHOF RHOBTB1 RAC3
2 cell division site GO:0032153 9.13 RND2 RHOF RHOBTB1
3 cell cortex GO:0005938 9.02 RND2 RHOV RHOF RHOBTB1 RAC3

Biological processes related to Ascaridiasis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of cell shape GO:0008360 9.72 RND2 RHOV RHOF RHOBTB1 RAC3
2 regulation of small GTPase mediated signal transduction GO:0051056 9.71 RHOV RHOF RHOBTB1 RAC3
3 small GTPase mediated signal transduction GO:0007264 9.65 RND2 RHOV RHOF RHOBTB1 RAC3
4 regulation of cell migration GO:0030334 9.63 RND2 RHOF RHOBTB1
5 actin filament bundle assembly GO:0051017 9.61 RND2 RHOF RHOBTB1
6 actin filament organization GO:0007015 9.55 RND2 RHOV RHOF RHOBTB1 RAC3
7 establishment or maintenance of actin cytoskeleton polarity GO:0030950 9.54 RND2 RHOF RHOBTB1
8 establishment or maintenance of cell polarity GO:0007163 9.49 RHOV RAC3
9 cell projection assembly GO:0030031 9.48 RHOV RAC3
10 regulation of actin cytoskeleton organization GO:0032956 9.35 RND2 RHOV RHOF RHOBTB1 RAC3
11 Rho protein signal transduction GO:0007266 9.02 RND2 RHOV RHOF RHOBTB1 RAC3

Molecular functions related to Ascaridiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.55 RND2 RHOV RHOF RHOBTB1 RAC3
2 GTP binding GO:0005525 9.35 RND2 RHOV RHOF RHOBTB1 RAC3
3 GTPase activity GO:0003924 9.02 RND2 RHOV RHOF RHOBTB1 RAC3
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Sources for Ascaridiasis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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