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MCID: ASC001
MIFTS: 32

Ascaridiasis

Categories: Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Ascaridiasis

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MalaCards integrated aliases for Ascaridiasis:

Name: Ascaridiasis 12 44 15 73
Ascariasis 73

Classifications:

MalaCards categories:
Global: Infectious diseases
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External Ids:

Disease Ontology 12 DOID:3108
MeSH 44 D001198
SNOMED-CT 68 2435008 76160002
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Summaries for Ascaridiasis

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Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the intestine of humans and birds with nematodes of the genus Ascaridia.

MalaCards based summary : Ascaridiasis, also known as ascariasis, is related to dysbaric osteonecrosis and conjunctival disease. An important gene associated with Ascaridiasis is STIMATE (STIM Activating Enhancer), and among its related pathways/superpathways are Th17 cell differentiation and Innate Lymphoid Cell Differentiation Pathways. The drugs Albendazole and Pyrantel have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and testes.

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Related Diseases for Ascaridiasis

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Diseases related to Ascaridiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 dysbaric osteonecrosis 10.1 PLG STH
2 conjunctival disease 10.1 IL13 PLG
3 intestinal perforation 10.1
4 vasculitis 10.1
5 cholangitis 10.1
6 filarial elephantiasis 10.0 IL10 STH
7 nickel allergic contact dermatitis 10.0 IL10 IL13
8 penicillin allergy 10.0 IL10 IL13
9 apple allergy 10.0 IL10 IL13
10 beta-lactam allergy 10.0 IL10 IL13
11 conjunctivitis 10.0 IL13 PLG
12 eosinophilic meningitis 10.0 IL10 IL13
13 peanut allergy 10.0 IL10 IL13
14 mycoplasma pneumoniae pneumonia 10.0 IL10 IL13
15 lipoid nephrosis 10.0 IL10 IL13
16 hyperlucent lung 10.0 IL10 NELFCD
17 paranasal sinus disease 10.0 IL10 IL13
18 nasal cavity disease 10.0 IL10 IL13
19 pericardial tuberculosis 10.0 IL10 NELFCD
20 nose disease 10.0 IL10 IL13
21 respiratory allergy 10.0 IL10 IL13
22 ige responsiveness, atopic 10.0 IL10 IL13
23 buruli ulcer 10.0 IL10 NELFCD
24 food allergy 10.0 IL10 IL13
25 transient hypogammaglobulinemia of infancy 10.0 IL10 NELFCD
26 upper respiratory tract disease 10.0 IL10 IL13
27 cutaneous leishmaniasis 10.0 IL10 IL13
28 immune deficiency disease 10.0 IL10 IL13
29 bronchial disease 10.0 IL10 IL13
30 schistosomiasis 10.0 IL10 IL13
31 bronchiolitis 10.0 IL10 IL13
32 immune system disease 9.9 IL10 IL13
33 proteasome-associated autoinflammatory syndrome 1 9.9 IL10 IL13
34 tetanus 9.9 IL10 IL13
35 trichuriasis 9.9 IL10 IL13 STH
36 parasitic helminthiasis infectious disease 9.9 IL10 IL13 STH
37 allergic asthma 9.9 IL10 IL13
38 respiratory system disease 9.9 IL10 IL13
39 allergic hypersensitivity disease 9.8 IL10 IL13

Graphical network of the top 20 diseases related to Ascaridiasis:



Diseases related to Ascaridiasis
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Symptoms & Phenotypes for Ascaridiasis

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Drugs & Therapeutics for Ascaridiasis

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Drugs for Ascaridiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 4,Not Applicable 54965-21-8 2082
2
Pyrantel Approved, Vet_approved Phase 4 15686-83-6
3 Immunologic Factors Phase 4
4 Antiparasitic Agents Phase 4,Not Applicable
5 Anti-Infective Agents Phase 4,Not Applicable
6 Pyrantel Pamoate Phase 4
7 Antiprotozoal Agents Phase 4,Not Applicable
8 Adjuvants, Immunologic Phase 4
9 Antimitotic Agents Phase 4,Not Applicable
10 Antirheumatic Agents Phase 4
11 Anthelmintics Phase 4,Not Applicable
12
Ivermectin Approved, Investigational, Vet_approved Not Applicable 70288-86-7 6474909
13
Mebendazole Approved, Vet_approved Not Applicable 31431-39-7 4030
14
Iodine Approved, Investigational 7553-56-2 807
15
Vitamin C Approved, Nutraceutical Not Applicable 50-81-7 5785 54670067
16 Micronutrients Not Applicable
17 Antioxidants Not Applicable
18 Trace Elements Not Applicable
19 Protective Agents Not Applicable
20 Vitamins Not Applicable
21 cadexomer iodine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy Albendazole and Levamisole Against STH on Unguja Completed NCT00659997 Phase 4 Albendazole;Levamisole
2 The Impact of Anthelmintic Treatment on the Incidence of Diarrheal Disease in Vietnamese School Children Withdrawn NCT02597556 Phase 4 Albendazole;Placebo
3 Impact of Repeated Anthelmintic Treatment on the Risk of Malaria in Kenyan School Children Completed NCT01658774 Not Applicable Albendazole
4 Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm Infections Completed NCT00207753 Not Applicable albendazole vs. combined albendazole/ivermectin treatment
5 The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989 Not Applicable
6 Intestinal Parasites in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435

Search NIH Clinical Center for Ascaridiasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: ascaridiasis

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Genetic Tests for Ascaridiasis

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Anatomical Context for Ascaridiasis

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MalaCards organs/tissues related to Ascaridiasis:

41
Lung, Liver, Testes, Small Intestine
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Publications for Ascaridiasis

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Articles related to Ascaridiasis:

(show top 50) (show all 279)
# Title Authors Year
1
Recurrent acute pancreatitis due to pancreatic duct ascariasis in a young man. ( 30096718 )
2018
2
Concomitant ascariasis as a factor in reducing the quality of life of patients with chronic pancreatitis. ( 30448792 )
2018
3
Ascariasis seen by videocapsule endoscopy. ( 29222943 )
2018
4
Gallbladder ascariasis in Kosovo - focus on ultrasound and conservative therapy: a case series. ( 29329599 )
2018
5
A Worm Hole: Liver Abscess in Ascariasis. ( 29518367 )
2018
6
EUS of pancreatic ascariasis. ( 29523472 )
2018
7
Biliary ascariasis presenting with gangrenous perforation of the gall bladder: report of a case and brief review of literature. ( 29649951 )
2018
8
Gastrointestinal: An unusual cause of biliary colic: Biliary ascariasis. ( 29659086 )
2018
9
High prevalence of ascariasis on two coral atolls in the Solomon Islands. ( 29800343 )
2018
10
Incidental diagnosis of appendiceal ascariasis during colonoscopy. ( 30115571 )
2018
11
Ascariasis as a model to study the helminth/allergy relationships. ( 30295330 )
2018
12
The inner tube sign in Ascariasis. ( 30498923 )
2018
13
Differential diagnosis of gallbladder ascariasis debris: the added value of contrast enhanced ultrasound with high frequency transducer. ( 30534646 )
2018
14
You Traveled the World and All You Got Was Ascariasis. ( 29056213 )
2017
15
A multilevel study of the environmental determinants of swine ascariasis in England. ( 29157367 )
2017
16
A Case of Biliary Ascariasis in Korea. ( 29320821 )
2017
17
Biliary ascariasis: mimicker of biliary stent. ( 29905283 )
2017
18
OVERDIAGNOSIS OF COELIAC DISEASE IN A PATIENT WITH ASCARIASIS AND GIARDIASIS. ( 29889407 )
2016
19
Hepatobiliary and pancreatic ascariasis-sonographic pictorial essay on four pediatric cases with acute biliary colic. ( 26690772 )
2016
20
Pancreatic ascariasis with periampullary carcinoma. ( 25709954 )
2015
21
Massive hepatobiliary ascariasis at autopsy. ( 25878238 )
2015
22
Ascariasis as a cause of hepatic abscess: A report of 3 cases. ( 26068350 )
2015
23
Ascariasis of gallbladder: a rare case report and a review of the literature. ( 24253312 )
2014
24
Wandering biliary ascariasis with hepatic abscess in a postmenopausal woman. ( 25481604 )
2014
25
Ascariasis as an unexpected cause of acute pancreatitis with cholangitis: a rare case report from urban area. ( 23306343 )
2013
26
Images in clinical medicine. Obstructive ileal ascariasis. ( 23465104 )
2013
27
Peritoneal ascariasis presenting as granulomatous peritonitis and omental cyst. ( 25046891 )
2013
28
Ascaridiasis in peafowl Pavo cristatus (Phasianidae) due to Ascaridia galli Schrank, 1788. ( 23082523 )
2012
29
Intestinal ascariasis in children. ( 20143068 )
2010
30
Management of biliary ascariasis in children living in an endemic area. ( 20225180 )
2010
31
Molecular diagnosis of ascariasis from human feces and description of a new Ascaris sp. genotype in Brazil. ( 19406577 )
2009
32
Biliary ascariasis in the Indian subcontinent: a study of 42 cases. ( 19568577 )
2009
33
Rare cause of biliary obstruction by ascariasis associated with choledocholithiasis. ( 19062498 )
2008
34
Fatal cholangitis in a patient with biliary ascaridiasis. ( 17653484 )
2007
35
Prevalence of biliary ascariasis and its relation to biliary lithiasis. ( 27277620 )
2006
36
Endoscopic management of early postoperative biliary ascariasis in patients with biliary tract surgery. ( 15175897 )
2004
37
Evolution of ascariasis in humans and pigs: a multi-disciplinary approach. ( 12687761 )
2003
38
Subclinical effects and fenbendazole treatment of turkey ascaridiasis under simulated field conditions. ( 12495049 )
2002
39
Ascaris and ascariasis. ( 11013758 )
2001
40
Pancreatitis with gallbladder ascariasis in a child: case report. ( 11299980 )
2001
41
Possible approach for serodiagnosis of ascariasis by evaluation of immunoglobulin G4 response using Ascaris lumbricoides somatic antigen. ( 11474031 )
2001
42
Biliary ascariasis with acute hemorrhagic pancreatitis: a case report. ( 11965640 )
1999
43
SURGICAL ASCARIASIS. ( 28775650 )
1999
44
Ascaris suum: a revision of its early migratory path and implications for human ascariasis. ( 9105307 )
1997
45
Periampullary carcinoma following biliary ascariasis--a case report. ( 9491675 )
1997
46
Evaluation of IgG4 response in ascariasis by ELISA for serodiagnosis. ( 8911447 )
1996
47
Content of some microelements in chickens with ascaridiasis under combined drug treatment. ( 7479645 )
1995
48
Phenotypic analysis of hypodense eosinophils derived from ascites of a patient with ascariasis. ( 7613167 )
1995
49
Biliary ascariasis. ( 7752968 )
1995
50
Biliary ascariasis and extrahepatic cholangiocarcinoma. ( 8882553 )
1995
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Variations for Ascaridiasis

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Expression for Ascaridiasis

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Search GEO for disease gene expression data for Ascaridiasis.
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Pathways for Ascaridiasis

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Pathways related to Ascaridiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Th17 cell differentiation 37
Show member pathways
 12.08 IL10 IL13 PPP3R1
2
Innate Lymphoid Cell Differentiation Pathways 65
11.36 IL10 IL13
3
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.28 IL10 IL13
4
Staphylococcus aureus infection 37
11.15 IL10 PLG
5
Interleukin-10 signaling 66
11.01 IL10 IL13
6
Th2 Differentiation Pathway 65
10.92 IL10 IL13
7
Initiation of transcription and translation elongation at the HIV-1 LTR 1
10.72 NELFCD PPP3R1
8
Cytokines and Inflammatory Response 1
10.42 IL10 IL13
9
OX40 Pathway 64
10.04 IL10 IL13
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GO Terms for Ascaridiasis

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Biological processes related to Ascaridiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of endothelial cell apoptotic process GO:2000352 8.96 IL10 IL13
2 positive regulation of macrophage activation GO:0043032 8.62 IL10 IL13
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Sources for Ascaridiasis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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