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MCID: ASC001
MIFTS: 35

Ascaridiasis

Categories: Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Ascaridiasis

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MalaCards integrated aliases for Ascaridiasis:

Name: Ascaridiasis 12 43 15 17 71
Ascariasis 71

Classifications:

MalaCards categories:
Global: Infectious diseases
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External Ids:

Disease Ontology 12 DOID:3108
MeSH 43 D001198
SNOMED-CT 67 76160002
UMLS 71 C0003950 C0003952
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Summaries for Ascaridiasis

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Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the intestine of humans and birds with nematodes of the genus Ascaridia.

MalaCards based summary : Ascaridiasis, also known as ascariasis, is related to ascaris lumbricoides infection and enterobiasis. An important gene associated with Ascaridiasis is STIMATE (STIM Activating Enhancer), and among its related pathways/superpathways are Signaling by Rho GTPases and p75 NTR receptor-mediated signalling. The drugs Pyrantel and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and lung.

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Related Diseases for Ascaridiasis

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Diseases related to Ascaridiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 ascaris lumbricoides infection 10.4
2 enterobiasis 10.3
3 parasitic helminthiasis infectious disease 10.3
4 ancylostomiasis 10.3
5 cholangitis 10.3
6 diarrhea 10.2
7 obstructive jaundice 10.2
8 cholecystitis 10.2
9 necatoriasis 10.2
10 acute pancreatitis 10.2
11 pancreatitis 10.2
12 peritonitis 10.2
13 intestinal obstruction 10.2
14 hypereosinophilic syndrome 10.2
15 taeniasis 10.0
16 thrombosis 10.0
17 filariasis 10.0
18 capillariasis 10.0
19 trichuriasis 10.0
20 trichostrongylosis 10.0
21 lymphadenitis 10.0
22 intestinal perforation 10.0
23 parasitic protozoa infectious disease 10.0
24 cryoglobulinemia 10.0
25 linitis plastica 10.0
26 elephantiasis 10.0
27 intestinal disease 10.0
28 appendicitis 10.0
29 vasculitis 10.0
30 toxocariasis 10.0
31 epileptic encephalopathy, early infantile, 24 9.7 STH ASPA
32 deafness, autosomal recessive 104 8.7 RHOV RHOF RHOBTB2 RAC3
33 toxic megacolon 8.3 RHOV RHOF RHOBTB2 RHOBTB1 RAC3
34 cardiomyopathy, familial hypertrophic, 1 8.2 RHOV RHOF RHOBTB2 RHOBTB1 RAC3

Graphical network of the top 20 diseases related to Ascaridiasis:



Diseases related to Ascaridiasis
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Symptoms & Phenotypes for Ascaridiasis

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Drugs & Therapeutics for Ascaridiasis

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Drugs for Ascaridiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pyrantel Approved, Vet_approved Phase 4 15686-83-6
2 Immunologic Factors Phase 4
3 Adjuvants, Immunologic Phase 4
4 Pyrantel Pamoate Phase 4
5 Antirheumatic Agents Phase 4
6
Iodine Approved, Investigational 7553-56-2 807
7
Ivermectin Approved, Investigational, Vet_approved 70288-86-7 6474909
8
Mebendazole Approved, Vet_approved 31431-39-7 4030
9
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067
10 cadexomer iodine
11 Trace Elements
12 Micronutrients
13 Vitamins
14 Antioxidants
15 Nutrients
16 Protective Agents
17 Anti-Bacterial Agents
18 Antibiotics, Antitubercular

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Longitudinal Study of Efficacy of Standard Albendazole Treatment Versus Levamisole/Pyrantel Pamoate on Soil Transmitted Helminth Infections Completed NCT00659997 Phase 4 Albendazole;Levamisole
2 A Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Impact of Anthelmintic Treatment on the Incidence of Diarrheal Disease in School Children in Southern Vietnam Withdrawn NCT02597556 Phase 4 Albendazole;Placebo
3 Diagnostics of Intestinal Parasitosis in Inhabitants of Kuyavian-Pomeranian Province in Poland Completed NCT03490435
4 Efficacy and Nutritional Assessment Following Albendazole and Combined Albendazole/Ivermectin Treatment for Intestinal Helminth Infections in Rural Guatemalan Schoolchildren Completed NCT00207753 albendazole vs. combined albendazole/ivermectin treatment
5 Impact of Repeated Anthelminthic Treatment on Malaria in School Children: an Individual Randomized, Double-blind, Placebo-controlled Trial in Western Kenya Completed NCT01658774 Albendazole
6 The Sero-prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989
7 Paediatric Surgery Across Sub-Saharan Africa: A Multi-Centre Prospective Cohort Study Completed NCT03185637
8 Re-infection Rates of Soil-transmitted Helminth Infections Among School-aged Children Following a Single or a 4-monthly Health Hygiene Education: an Open Label Clinical Trial Active, not recruiting NCT04227834

Search NIH Clinical Center for Ascaridiasis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Ivermectin
Mebendazole
Pyrantel
Pyrantel Pamoate

Cochrane evidence based reviews: ascaridiasis

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Genetic Tests for Ascaridiasis

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Anatomical Context for Ascaridiasis

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MalaCards organs/tissues related to Ascaridiasis:

40
Liver, Testes, Lung, Small Intestine, Kidney, Skin, Eye
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Publications for Ascaridiasis

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Articles related to Ascaridiasis:

(show top 50) (show all 2326)
# Title Authors PMID Year
1
Biliary Ascariasis: An Unusual Case of Obstructive Jaundice. 61
30710698 2020
2
Biliary ascariasis and severe bacterial outcomes: Report of three cases from a paediatric hospital in Brazil. 61
32240824 2020
3
Fungal and Parasitic Infections of the Liver. 61
32389369 2020
4
Triterpenoid and saponin rich Phytolacca dodecandra L'Herit(Endod): A review on its phytochemistry and pharmacological properties. 61
32552643 2020
5
Interactions between helminths and tuberculosis infections: Implications for tuberculosis diagnosis and vaccination in Africa. 61
32498074 2020
6
Enteric parasitic infections in children and dogs in resource-poor communities in northeastern Brazil: Identifying priority prevention and control areas. 61
32516309 2020
7
Pictorial Review of Thoracic Parasitic Diseases: A Radiologic Guide. 61
31978430 2020
8
Whipworm and roundworm infections. 61
32467581 2020
9
Anthelmintic drugs for treating ascariasis. 61
32289194 2020
10
Pro-fibrinolytic potential of the third larval stage of Ascaris suum as a possible mechanism facilitating its migration through the host tissues. 61
32312291 2020
11
Imported Infections in Rural Mid-West United States - A Report from a Tertiary Care Center. 61
32308221 2020
12
Study on the population evolution of Ascaris lumbricoides and Ascaris suum based on whole genome resequencing. 61
32126343 2020
13
Biliary ascariasis: particular cause of biliary tract infection. 61
32140497 2020
14
Epidemiology of Parasitic Infections in the West Bank and Gaza Strip, Palestine. 61
31769396 2020
15
High anti-Ascaris seroprevalence in fattening pigs in Sichuan, China, calls for improved management strategies. 61
32051006 2020
16
Ascaris lumbricoides and Ascaris suum vary in their larval burden in a mouse model. 61
32100653 2020
17
Distribution of ascariasis, trichuriasis and hookworm infections in Ogun State, Southwestern Nigeria. 61
32511237 2020
18
Differential diagnosis of focal gallbladder lesions: The added value of contrast enhanced ultrasound with liner transducers. 61
31306115 2020
19
Toxocariasis: A neglected infection for the Anthropocene epoch. 61
32381232 2020
20
Not everything in the gallbladder is gallstones: an unusual case of biliary ascariasis. 61
31938556 2019
21
Exposure to Ascaris lumbricoides infection and risk of childhood asthma in north of Iran. 61
31350726 2019
22
Assessing the Parasitic Burden in a Late Antique Florentine Emergency Burial Site. 61
31914509 2019
23
The role of the liver in the migration of parasites of global significance. 61
31703729 2019
24
Comorbidity associated to Ascaris suum infection during pulmonary fibrosis exacerbates chronic lung and liver inflammation and dysfunction but not affect the parasite cycle in mice. 61
31765381 2019
25
BioStruct-Africa: empowering Africa-based scientists through structural biology knowledge transfer and mentoring - recent advances and future perspectives. 61
31490179 2019
26
Ascariasis Causing Biliary Colic. 61
31750371 2019
27
Parasitic infections in Malaysian aborigines with pulmonary tuberculosis: a comparative cross-sectional study. 61
31363922 2019
28
An Unwanted Guest in the Biliary Tract: A Case Report. 61
32329468 2019
29
Anti-Ascaris suum immunoglobulin Y as a novel biotechnological tool for the diagnosis of human ascariasis. 61
31409433 2019
30
The liver proteome in a mouse model for Ascaris suum resistance and susceptibility: evidence for an altered innate immune response. 61
31412915 2019
31
Rare presentation of haemobilia and Loeffler's pneumonia in a child by ascaris lumbricoides. 61
31466983 2019
32
Gallbladder Perforation Due to Ascaris lumbricoides in a Pregnant Woman and 6 Year Old Girl from Afghanistan: Case Report. 61
31673268 2019
33
Old Antiprotozoal Drugs: Are They Still Viable Options for Parasitic Diseases or New Options for Other Diseases? 61
31264538 2019
34
Ascariasis as a model to study the helminth/allergy relationships. 61
30295330 2019
35
In vitro and in vivoAreca catechu crude aqueous extract as an anthelmintic against Ascaridia galli infection in chickens. 61
31440008 2019
36
Small bowel obstruction complicating an Ascaris lumbricoides infestation in a 4-year-old male: a case report. 61
31122293 2019
37
Dual Parasitization of the Biliary Tree: First Reported Case. 61
31616753 2019
38
Secular Trends of Ascariasis Infestation and Nutritional Status in Chinese Children From 2000 to 2014: Evidence From 4 Successive National Surveys. 61
31139673 2019
39
Biological role of excretory-secretory proteins in endemic parasites of Latin America and the Caribbean. 61
31092301 2019
40
[Interpretation of Diagnosis of Ascariasis (WS/565-2017)]. 61
31184060 2019
41
Ascariasis and its relationship with selected psycho-neurological symptoms among children and adults in Poland. 61
31099762 2019
42
Efficacy of Albendazole and Mebendazole With or Without Levamisole for Ascariasis and Trichuriasis. 61
31110573 2019
43
The inner tube sign in Ascariasis. 61
30498923 2019
44
Imaging of toxocariasis. 61
30861557 2019
45
Ultrasonography for early diagnosis of Toxocara canis infection in puppies. 61
30706166 2019
46
Molecular analysis of human- and pig-derived Ascaris in Honduras. 61
29502555 2019
47
Comparative analysis of excretory-secretory antigens of Anisakis simplex, Pseudoterranova decipiens and Contracaecum osculatum regarding their applicability for specific serodiagnosis of human anisakidosis based on IgG-ELISA. 61
30584924 2019
48
Predictors of therapeutic failure among patients with acute brucellosis treated by dual therapy with doxycycline-rifampin. 61
30411836 2019
49
Ascariasis-associated perforated appendicitis: Computed tomography findings. 61
31650119 2019
50
Incidental diagnosis of appendiceal ascariasis during colonoscopy. 61
30115571 2019
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Variations for Ascaridiasis

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Expression for Ascaridiasis

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Search GEO for disease gene expression data for Ascaridiasis.
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Pathways for Ascaridiasis

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Pathways related to Ascaridiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Signaling by Rho GTPases 65
Show member pathways
 12.21 RHOV RHOF RHOBTB2 RHOBTB1 RAC3
2
p75 NTR receptor-mediated signalling 65
Show member pathways
 11.78 RHOV RHOF RHOBTB2 RHOBTB1 RAC3
3
Ubiquitin mediated proteolysis 36
11.3 RHOBTB2 RHOBTB1
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GO Terms for Ascaridiasis

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Cellular components related to Ascaridiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.95 STH RHOV RHOF RHOBTB2 RHOBTB1 RAC3
2 cytoskeleton GO:0005856 9.77 RHOV RHOF RHOBTB2 RHOBTB1 RAC3
3 cell projection GO:0042995 9.72 RHOV RHOF RHOBTB2 RHOBTB1 RAC3
4 intracellular membrane-bounded organelle GO:0043231 9.65 RHOV RHOF RHOBTB2 RHOBTB1 RAC3
5 cytoplasmic vesicle GO:0031410 9.55 RHOV RHOF RHOBTB2 RHOBTB1 RAC3
6 cell division site GO:0032153 9.13 RHOF RHOBTB2 RHOBTB1
7 cell cortex GO:0005938 9.02 RHOV RHOF RHOBTB2 RHOBTB1 RAC3

Biological processes related to Ascaridiasis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 actin cytoskeleton organization GO:0030036 9.85 RHOV RHOF RHOBTB2 RHOBTB1 RAC3
2 regulation of cell shape GO:0008360 9.83 RHOV RHOF RHOBTB2 RHOBTB1 RAC3
3 actin filament organization GO:0007015 9.8 RHOV RHOF RHOBTB2 RHOBTB1 RAC3
4 regulation of small GTPase mediated signal transduction GO:0051056 9.77 RHOV RHOF RHOBTB2 RHOBTB1 RAC3
5 small GTPase mediated signal transduction GO:0007264 9.72 RHOV RHOF RHOBTB2 RHOBTB1 RAC3
6 regulation of cell migration GO:0030334 9.69 RHOF RHOBTB2 RHOBTB1
7 actin filament bundle assembly GO:0051017 9.67 RHOF RHOBTB2 RHOBTB1
8 establishment or maintenance of actin cytoskeleton polarity GO:0030950 9.65 RHOF RHOBTB2 RHOBTB1
9 regulation of actin cytoskeleton organization GO:0032956 9.65 RHOV RHOF RHOBTB2 RHOBTB1 RAC3
10 Rho protein signal transduction GO:0007266 9.55 RHOV RHOF RHOBTB2 RHOBTB1 RAC3
11 cell projection assembly GO:0030031 9.54 RHOV RAC3
12 engulfment of apoptotic cell GO:0043652 9.52 RHOBTB2 RHOBTB1
13 establishment or maintenance of cell polarity GO:0007163 9.35 RHOV RHOF RHOBTB2 RHOBTB1 RAC3
14 cortical cytoskeleton organization GO:0030865 9.02 RHOV RHOF RHOBTB2 RHOBTB1 RAC3

Molecular functions related to Ascaridiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.65 RHOV RHOF RHOBTB2 RHOBTB1 RAC3
2 protein kinase binding GO:0019901 9.55 RHOV RHOF RHOBTB2 RHOBTB1 RAC3
3 GTP binding GO:0005525 9.35 RHOV RHOF RHOBTB2 RHOBTB1 RAC3
4 GTPase activity GO:0003924 9.02 RHOV RHOF RHOBTB2 RHOBTB1 RAC3
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Sources for Ascaridiasis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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