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MCID: ASC001
MIFTS: 36

Ascaridiasis

Categories: Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Ascaridiasis

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MalaCards integrated aliases for Ascaridiasis:

Name: Ascaridiasis 12 45 15 17 74
Ascariasis 74

Classifications:

MalaCards categories:
Global: Infectious diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3108
MeSH 45 D001198
SNOMED-CT 69 2435008 76160002
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Summaries for Ascaridiasis

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Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the intestine of humans and birds with nematodes of the genus Ascaridia.

MalaCards based summary : Ascaridiasis, also known as ascariasis, is related to dysbaric osteonecrosis and conjunctival disease. An important gene associated with Ascaridiasis is STIMATE (STIM Activating Enhancer), and among its related pathways/superpathways are Th17 cell differentiation and Glucocorticoid receptor regulatory network. The drugs Albendazole and Pyrantel have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and testes, and related phenotype is endocrine/exocrine gland.

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Related Diseases for Ascaridiasis

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Diseases related to Ascaridiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 dysbaric osteonecrosis 10.2 PLG STH
2 conjunctival disease 10.2 IL13 PLG
3 filarial elephantiasis 10.2 IL10 STH
4 nickel allergic contact dermatitis 10.2 IL10 IL13
5 apple allergy 10.2 IL10 IL13
6 beta-lactam allergy 10.1 IL10 IL13
7 eosinophilic meningitis 10.1 IL10 IL13
8 peanut allergy 10.1 IL10 IL13
9 mycoplasma pneumoniae pneumonia 10.1 IL10 IL13
10 radiculopathy 10.1 IL10 IL13
11 lipoid nephrosis 10.1 IL10 IL13
12 paranasal sinus disease 10.1 IL10 IL13
13 conjunctivitis 10.1 IL13 PLG
14 nasal cavity disease 10.1 IL10 IL13
15 nose disease 10.1 IL10 IL13
16 respiratory allergy 10.1 IL10 IL13
17 hyperlucent lung 10.1 IL10 NELFCD
18 pericardial tuberculosis 10.1 IL10 NELFCD
19 ige responsiveness, atopic 10.1 IL10 IL13
20 intestinal perforation 10.1
21 vasculitis 10.1
22 cholangitis 10.1
23 buruli ulcer 10.1 IL10 NELFCD
24 food allergy 10.1 IL10 IL13
25 upper respiratory tract disease 10.1 IL10 IL13
26 transient hypogammaglobulinemia of infancy 10.1 IL10 NELFCD
27 cutaneous leishmaniasis 10.0 IL10 IL13
28 hepatic vascular disease 10.0 AFP PLG
29 leishmaniasis 10.0 IL10 IL13
30 immune deficiency disease 10.0 IL10 IL13
31 vein disease 10.0 AFP PLG
32 bronchial disease 10.0 IL10 IL13
33 schistosomiasis 10.0 IL10 IL13
34 tracheal cancer 10.0 AFP NELFCD
35 testicular disease 10.0 AFP IL10
36 bronchiolitis 10.0 IL10 IL13
37 hepatitis a 10.0 AFP IL10
38 proteasome-associated autoinflammatory syndrome 1 9.9 IL10 IL13
39 trichuriasis 9.9 IL10 IL13 STH
40 parasitic helminthiasis infectious disease 9.9 IL10 IL13 STH
41 tetanus 9.9 IL10 IL13
42 allergic asthma 9.9 IL10 IL13
43 respiratory system disease 9.7 IL10 IL13

Graphical network of the top 20 diseases related to Ascaridiasis:



Diseases related to Ascaridiasis
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Symptoms & Phenotypes for Ascaridiasis

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MGI Mouse Phenotypes related to Ascaridiasis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.02 AFP IL10 IL13 PLG PPP3R1
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Drugs & Therapeutics for Ascaridiasis

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Drugs for Ascaridiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 4,Not Applicable 54965-21-8 2082
2
Pyrantel Approved, Vet_approved Phase 4 15686-83-6
3 Anthelmintics Phase 4,Not Applicable
4 Pyrantel Pamoate Phase 4
5 Anti-Infective Agents Phase 4,Not Applicable
6 Adjuvants, Immunologic Phase 4
7 Antiparasitic Agents Phase 4,Not Applicable
8 Immunologic Factors Phase 4
9 Antimitotic Agents Phase 4,Not Applicable
10 Antiprotozoal Agents Phase 4,Not Applicable
11 Antirheumatic Agents Phase 4
12
Ivermectin Approved, Investigational, Vet_approved Not Applicable 70288-86-7 6474909
13
Mebendazole Approved, Vet_approved Not Applicable 31431-39-7 4030
14
Iodine Approved, Investigational 7553-56-2 807
15
Vitamin C Approved, Nutraceutical Not Applicable 50-81-7 5785 54670067
16 Nutrients Not Applicable
17 Trace Elements Not Applicable
18 Vitamins Not Applicable
19 Antioxidants Not Applicable
20 Micronutrients Not Applicable
21 Protective Agents Not Applicable
22 cadexomer iodine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy Albendazole and Levamisole Against STH on Unguja Completed NCT00659997 Phase 4 Albendazole;Levamisole
2 The Impact of Anthelmintic Treatment on the Incidence of Diarrheal Disease in Vietnamese School Children Withdrawn NCT02597556 Phase 4 Albendazole;Placebo
3 Impact of Repeated Anthelmintic Treatment on the Risk of Malaria in Kenyan School Children Completed NCT01658774 Not Applicable Albendazole
4 Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm Infections Completed NCT00207753 Not Applicable albendazole vs. combined albendazole/ivermectin treatment
5 The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989 Not Applicable
6 Intestinal Parasites in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435

Search NIH Clinical Center for Ascaridiasis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: ascaridiasis

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Genetic Tests for Ascaridiasis

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Anatomical Context for Ascaridiasis

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MalaCards organs/tissues related to Ascaridiasis:

42
Liver, Lung, Testes, Small Intestine
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Publications for Ascaridiasis

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Articles related to Ascaridiasis:

(show top 50) (show all 244)
# Title Authors Year
1
Biliary ascariasis - an unusual case of obstructive jaundice. ( 30710698 )
2019
2
Recurrent acute pancreatitis due to pancreatic duct ascariasis in a young man. ( 30096718 )
2018
3
Successful Elimination of Gallbladder Ascariasis by Conservative Therapy, Followed by Cholecystectomy due to Developing Cholecystitis. ( 30643654 )
2018
4
Concomitant ascariasis as a factor in reducing the quality of life of patients with chronic pancreatitis. ( 30448792 )
2018
5
Ascariasis seen by videocapsule endoscopy. ( 29222943 )
2018
6
Gallbladder ascariasis in Kosovo - focus on ultrasound and conservative therapy: a case series. ( 29329599 )
2018
7
A Worm Hole: Liver Abscess in Ascariasis. ( 29518367 )
2018
8
EUS of pancreatic ascariasis. ( 29523472 )
2018
9
Biliary ascariasis presenting with gangrenous perforation of the gall bladder: report of a case and brief review of literature. ( 29649951 )
2018
10
Gastrointestinal: An unusual cause of biliary colic: Biliary ascariasis. ( 29659086 )
2018
11
High prevalence of ascariasis on two coral atolls in the Solomon Islands. ( 29800343 )
2018
12
Incidental diagnosis of appendiceal ascariasis during colonoscopy. ( 30115571 )
2018
13
Ascariasis as a model to study the helminth/allergy relationships. ( 30295330 )
2018
14
The inner tube sign in Ascariasis. ( 30498923 )
2018
15
Differential diagnosis of gallbladder ascariasis debris: the added value of contrast enhanced ultrasound with high frequency transducer. ( 30534646 )
2018
16
You Traveled the World and All You Got Was Ascariasis. ( 29056213 )
2017
17
A multilevel study of the environmental determinants of swine ascariasis in England. ( 29157367 )
2017
18
A Case of Biliary Ascariasis in Korea. ( 29320821 )
2017
19
Biliary ascariasis: mimicker of biliary stent. ( 29905283 )
2017
20
OVERDIAGNOSIS OF COELIAC DISEASE IN A PATIENT WITH ASCARIASIS AND GIARDIASIS. ( 29889407 )
2016
21
Ascaridiasis in peafowl Pavo cristatus (Phasianidae) due to Ascaridia galli Schrank, 1788. ( 23082523 )
2012
22
Fatal cholangitis in a patient with biliary ascaridiasis. ( 17653484 )
2007
23
Prevalence of biliary ascariasis and its relation to biliary lithiasis. ( 27277620 )
2006
24
Subclinical effects and fenbendazole treatment of turkey ascaridiasis under simulated field conditions. ( 12495049 )
2002
25
SURGICAL ASCARIASIS. ( 28775650 )
1999
26
Content of some microelements in chickens with ascaridiasis under combined drug treatment. ( 7479645 )
1995
27
Phenotypic analysis of hypodense eosinophils derived from ascites of a patient with ascariasis. ( 7613167 )
1995
28
Renal vasculitis associated with ascaridiasis with good prognosis. ( 8321375 )
1993
29
Ascariasis and post-operative recovery. ( 8488591 )
1993
30
Some pathological and biochemical studies on experimental ascaridiasis in chickens. ( 1865892 )
1991
31
Biliary ascariasis--a worm in the duct. ( 2056950 )
1991
32
Ascariasis-Hepatobiliary and pancreatic involvement. ( 29772636 )
1991
33
Ascariasis. ( 2566869 )
1989
34
Hepatic ascaridiasis. ( 3608925 )
1987
35
Fatal human ascariasis following secondary massive infection. ( 3953945 )
1986
36
Biliary ascariasis. ( 6484698 )
1984
37
Metabolic end products of helminths: their degradation and excretion by the host. Biochemical approach to the diagnosis of ascaridiasis and other helminthiases. ( 6123250 )
1981
38
Intestinal perforation and pleuroperitonitis in ascaridiasis in White Leghorn cockerel. ( 552707 )
1979
39
Ascariasis and toxocariasis. II. Difficulties in the differential serological diagnosis employing a Toxocara canis antigen. ( 828293 )
1976
40
Experimental ascaridiasis IV. Various aspects of ascarid behaviour within the organophenotes following experimental infection of chickens. ( 4448433 )
1974
41
The morbidity of human ascariasis. ( 4501103 )
1972
42
Treatment of ascariasis with pyrantel pamoate in Iran. ( 4564698 )
1972
43
Disordered small bowel pattern in ascariasis. ( 4636094 )
1972
44
Ascariasis of the biliary system. ( 5031587 )
1972
45
Ectopic ascariasis. ( 5058178 )
1972
46
Neonatal ascariasis. ( 5074356 )
1972
47
Comparison of pyrantel pamoate and piperazine phosphate in the treatment of ascariasis. ( 4936116 )
1971
48
Clinical appraisal of 200 cases of ascariasis with special reference to surgical complications. ( 5141459 )
1971
49
Ascariasis--a health hazard. ( 5141463 )
1971
50
Basophil leucocytes in ascariasis. ( 5151049 )
1971
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Variations for Ascaridiasis

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Expression for Ascaridiasis

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Search GEO for disease gene expression data for Ascaridiasis.
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Pathways for Ascaridiasis

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Pathways related to Ascaridiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Th17 cell differentiation 38
Show member pathways
 12.08 IL10 IL13 PPP3R1
2
Glucocorticoid receptor regulatory network 1
11.39 AFP IL13
3
Innate Lymphoid Cell Differentiation Pathways 66
11.36 IL10 IL13
4
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.28 IL10 IL13
5
Staphylococcus aureus infection 38
11.24 IL10 PLG
6
Interleukin-10 signaling 67
11.01 IL10 IL13
7
Th2 Differentiation Pathway 66
10.92 IL10 IL13
8
Initiation of transcription and translation elongation at the HIV-1 LTR 1
10.72 NELFCD PPP3R1
9
Cytokines and Inflammatory Response 1
10.42 IL10 IL13
10
OX40 Pathway 65
10.04 IL10 IL13
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GO Terms for Ascaridiasis

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Biological processes related to Ascaridiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of endothelial cell apoptotic process GO:2000352 8.96 IL10 IL13
2 positive regulation of macrophage activation GO:0043032 8.62 IL10 IL13
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Sources for Ascaridiasis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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