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MCID: ASC001
MIFTS: 36

Ascaridiasis

Categories: Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Ascaridiasis

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MalaCards integrated aliases for Ascaridiasis:

Name: Ascaridiasis 12 44 15 17 71
Ascariasis 71

Classifications:

MalaCards categories:
Global: Infectious diseases
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External Ids:

Disease Ontology 12 DOID:3108
MeSH 44 D001198
SNOMED-CT 67 2435008
UMLS 71 C0003950 C0003952
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Summaries for Ascaridiasis

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Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the intestine of humans and birds with nematodes of the genus Ascaridia.

MalaCards based summary : Ascaridiasis, also known as ascariasis, is related to ascaris lumbricoides infection and enterobiasis. An important gene associated with Ascaridiasis is RAC3 (Rac Family Small GTPase 3), and among its related pathways/superpathways are Signaling by GPCR and Sertoli-Sertoli Cell Junction Dynamics. The drugs Pyrantel and Adjuvants, Immunologic have been mentioned in the context of this disorder. Affiliated tissues include small intestine, kidney and pancreas.

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Related Diseases for Ascaridiasis

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Diseases related to Ascaridiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 ascaris lumbricoides infection 10.2
2 enterobiasis 10.1
3 parasitic helminthiasis infectious disease 10.1
4 ancylostomiasis 10.1
5 cholangitis 10.1
6 obstructive jaundice 10.0
7 cholecystitis 10.0
8 intestinal perforation 10.0
9 necatoriasis 10.0
10 acute pancreatitis 10.0
11 peritonitis 10.0
12 intestinal obstruction 10.0
13 hypereosinophilic syndrome 10.0
14 taeniasis 9.8
15 filariasis 9.8
16 capillariasis 9.8
17 trichuriasis 9.8
18 trichostrongylosis 9.8
19 lymphadenitis 9.8
20 parasitic protozoa infectious disease 9.8
21 cryoglobulinemia 9.8
22 linitis plastica 9.8
23 elephantiasis 9.8
24 pancreatitis 9.8
25 intestinal disease 9.8
26 appendicitis 9.8
27 vasculitis 9.8
28 toxocariasis 9.8
29 deafness, autosomal recessive 104 9.0 RHOV RHOJ RHOF RHOBTB1 RAC3
30 toxic megacolon 8.3 RND2 RHOV RHOJ RHOF RHOBTB2 RHOBTB1
31 cardiomyopathy, familial hypertrophic, 1 8.2 RND2 RHOV RHOJ RHOF RHOBTB2 RHOBTB1

Graphical network of the top 20 diseases related to Ascaridiasis:



Diseases related to Ascaridiasis
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Symptoms & Phenotypes for Ascaridiasis

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Drugs & Therapeutics for Ascaridiasis

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Drugs for Ascaridiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pyrantel Approved, Vet_approved Phase 4 15686-83-6
2 Adjuvants, Immunologic Phase 4
3 Immunologic Factors Phase 4
4 Pyrantel Pamoate Phase 4
5 Antirheumatic Agents Phase 4
6
Albendazole Approved, Vet_approved Phase 3 54965-21-8 2082
7
Ivermectin Approved, Investigational, Vet_approved Phase 3 70288-86-7 6474909
8 Anti-Infective Agents Phase 3
9 Anthelmintics Phase 3
10 Antiparasitic Agents Phase 3
11 Antiprotozoal Agents Phase 3
12 Antimitotic Agents Phase 3
13 Tubulin Modulators Phase 3
14 Milbemycin Phase 3
15
Mebendazole Approved, Vet_approved 31431-39-7 4030
16
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067
17 Nutrients
18 Protective Agents
19 Micronutrients
20 Antioxidants
21 Trace Elements
22 Vitamins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Longitudinal Study of Efficacy of Standard Albendazole Treatment Versus Levamisole/Pyrantel Pamoate on Soil Transmitted Helminth Infections Completed NCT00659997 Phase 4 Albendazole;Levamisole
2 Efficacy and Safety of Combination Moxidectin and Albendazole, Ivermectin and Albendazole and Albendazole Alone in Adolescents and Adults Infected With Trichuris Trichiura: a Randomized Controlled Trial Not yet recruiting NCT04726969 Phase 3 Moxidectin 2 mg Oral Tablet;Albendazole 400 mg Oral Tablet;Ivermectin 3 mg Oral Tablet
3 Efficacy and Safety of Moxidectin and Albendazole Compared to Ivermectin and Albendazole Co-administration in Adolescents Infected With Trichuris Trichiura: a Randomized Controlled Trial Not yet recruiting NCT04700423 Phase 2, Phase 3 moxidectin (8 mg) / albendazole (400 mg);ivermectin (200 µg/kg) / albendazole (400 mg);ALBENDAZOLE 400 Mg ORAL TABLET [ZENTEL];ivermectin (200 µg/kg);moxidectin (8 mg)
4 The Sero-prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989
5 Efficacy and Nutritional Assessment Following Albendazole and Combined Albendazole/Ivermectin Treatment for Intestinal Helminth Infections in Rural Guatemalan Schoolchildren Completed NCT00207753 albendazole vs. combined albendazole/ivermectin treatment
6 Impact of Repeated Anthelminthic Treatment on Malaria in School Children: an Individual Randomized, Double-blind, Placebo-controlled Trial in Western Kenya Completed NCT01658774 Albendazole
7 Re-infection Rates of Soil-transmitted Helminth Infections Among School-aged Children Following a Single or a 4-monthly Health Hygiene Education: an Open Label Clinical Trial Active, not recruiting NCT04227834

Search NIH Clinical Center for Ascaridiasis

Inferred drug relations via UMLS 71 / NDF-RT 51 :


Ivermectin
Mebendazole
Pyrantel
Pyrantel Pamoate

Cochrane evidence based reviews: ascaridiasis

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Genetic Tests for Ascaridiasis

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Anatomical Context for Ascaridiasis

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MalaCards organs/tissues related to Ascaridiasis:

40
Small Intestine, Kidney, Pancreas, Skin, Eye, Liver, Appendix
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Publications for Ascaridiasis

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Articles related to Ascaridiasis:

(show top 50) (show all 2388)
# Title Authors PMID Year
1
Trilateral Relationship: Ascaris, Microbiota, and Host Cells. 61
33008723 2021
2
Evaluation of crude adult Ascaris suum intestinal tract homogenate in inducing protective IgG production against A. suum larvae in BALB/c mice. 61
33307097 2021
3
Prevalence of Intestinal Parasites and Salmonella typhi among Food Handlers Working in Catering Establishments of Public Institutes Found in Dawuro Zone, South-Western Ethiopia. 61
33510904 2021
4
Vaccination with chimeric protein induces protection in murine model against ascariasis. 61
33248854 2021
5
A Rare Case of Ascariasis-Induced Cholangitis Complicated With Klebsiella pneumoniae Bacteremia and Liver Microabscesses. 61
33564511 2021
6
Traditional herbal medicine therapy of gallbladder ascariasis: a case report. 61
33514402 2021
7
Intestinal Obstruction in a Child with Massive Ascariasis. 61
33505753 2021
8
Genomic Signatures of Coevolution between Nonmodel Mammals and Parasitic Roundworms. 61
32960966 2021
9
Triterpenoid and Saponin Rich Phytolacca dodecandra L'Herit (Endod): A Review on Its Phytochemistry and Pharmacological Properties. 61
32552643 2021
10
Ascariasis, Amebiasis and Giardiasis in Mexican children: distribution and geographical, environmental and socioeconomic risk factors. 61
33177788 2020
11
Prevalence of Ascaris lumbricoides in contaminated faecal samples of children residing in urban areas of Lahore, Pakistan. 61
33311542 2020
12
Quantitative lipidomic analysis of Ascaris suum. 61
33264279 2020
13
Hidden Nematode Causing Recurrent Pancreatitis: A Case Report. 61
33409075 2020
14
Ascaris Lumbricoides Infestation as an Unexpected Cause of Acute Pancreatitis. 61
33489520 2020
15
Molecular evidence of hybridization between pig and human Ascaris indicates an interbred species complex infecting humans. 61
33155980 2020
16
[Ascariasis in the intrahepatic biliary duct: about a case in pediatrics]. 61
32924404 2020
17
Loop-Mediated Isothermal Amplification as Point-of-Care Diagnosis for Neglected Parasitic Infections. 61
33126446 2020
18
S-Methyl-(2-Methoxycarbonylamino-Benzimidazole-5) Thiosulfonate as a Potential Antiparasitic Agent-Its Action on the Development of Ascaris suum Eggs In Vitro. 61
33113959 2020
19
Ascaris-mimicking common bile duct stone: A case report. 61
33083410 2020
20
Mitochondrial phylogenomics of human-type Ascaris, pig-type Ascaris, and hybrid Ascaris populations. 61
33053491 2020
21
A first nation-wide assessment of soil-transmitted helminthiasis in Fijian primary schools, and factors associated with the infection, using a lymphatic filariasis transmission assessment survey as surveillance platform. 61
32976499 2020
22
Ascariasis in common bile duct resulting in a subhepatic abscess. 61
33094600 2020
23
Soil-transmitted helminthiasis: A neglected tropical disease among urban slum dwelling school-aged children of a sub-Saharan African city. 61
32687117 2020
24
Biliary ascariasis and severe bacterial outcomes: Report of three cases from a paediatric hospital in Brazil. 61
32240824 2020
25
Biliary Ascariasis: An Unusual Case of Obstructive Jaundice. 61
30710698 2020
26
Fungal and Parasitic Infections of the Liver. 61
32389369 2020
27
Interactions between helminths and tuberculosis infections: Implications for tuberculosis diagnosis and vaccination in Africa. 61
32498074 2020
28
Enteric parasitic infections in children and dogs in resource-poor communities in northeastern Brazil: Identifying priority prevention and control areas. 61
32516309 2020
29
Pictorial Review of Thoracic Parasitic Diseases: A Radiologic Guide. 61
31978430 2020
30
Whipworm and roundworm infections. 61
32467581 2020
31
Anthelmintic drugs for treating ascariasis. 61
32289194 2020
32
Pro-fibrinolytic potential of the third larval stage of Ascaris suum as a possible mechanism facilitating its migration through the host tissues. 61
32312291 2020
33
Imported Infections in Rural Mid-West United States - A Report from a Tertiary Care Center. 61
32308221 2020
34
Study on the population evolution of Ascaris lumbricoides and Ascaris suum based on whole genome resequencing. 61
32126343 2020
35
Biliary ascariasis: particular cause of biliary tract infection. 61
32140497 2020
36
Ascaris lumbricoides and Ascaris suum vary in their larval burden in a mouse model. 61
32100653 2020
37
High anti-Ascaris seroprevalence in fattening pigs in Sichuan, China, calls for improved management strategies. 61
32051006 2020
38
Epidemiology of Parasitic Infections in the West Bank and Gaza Strip, Palestine. 61
31769396 2020
39
Human Ascariasis: An Updated Review. 61
32628606 2020
40
Distribution of ascariasis, trichuriasis and hookworm infections in Ogun State, Southwestern Nigeria. 61
32511237 2020
41
[Current Incidence and Contamination Sources of Ascariasis in Japan]. 61
33012763 2020
42
Old Antiprotozoal Drugs: Are They Still Viable Options for Parasitic Infections or New Options for Other Diseases? 61
31264538 2020
43
[Features of granulomatous inflammation in helminthiasis, mycoses and human protozoal diseases in forensic medical practice]. 61
33180415 2020
44
Antibacterial and Antifungal Activities of the Leaf Exudate of Aloe megalacantha Baker. 61
33061982 2020
45
Differential diagnosis of focal gallbladder lesions: The added value of contrast enhanced ultrasound with liner transducers. 61
31306115 2020
46
Interactions between malnutrition, soil-transmitted helminthiasis and poverty among children living in periurban communities in Maranhao State, Northeastern Brazil. 61
33027397 2020
47
Evaluation of Abortifacient Effect of Rumex nepalensis Spreng Among Pregnant Swiss Albino Rats: Laboratory-Based Study. 61
32801949 2020
48
Toxocariasis: A neglected infection for the Anthropocene epoch. 61
32381232 2020
49
Soil-transmitted helminth infections among pre-school aged children in Gamo Gofa zone, Southern Ethiopia: Prevalence, intensity and intervention status. 61
33320918 2020
50
Hand hygiene intervention to optimize helminth infection control: Design and baseline results of Mikono Safi-An ongoing school-based cluster-randomised controlled trial in NW Tanzania. 61
33296365 2020
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Variations for Ascaridiasis

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Expression for Ascaridiasis

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Search GEO for disease gene expression data for Ascaridiasis.
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Pathways for Ascaridiasis

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Pathways related to Ascaridiasis according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Signaling by GPCR 65
Show member pathways
 13.54 RHOV RHOJ RHOF RHOBTB2 RHOBTB1 RAC3
2
Sertoli-Sertoli Cell Junction Dynamics 63
Show member pathways
 12.4 RND2 RHOJ RAC3
3
Actin Nucleation by ARP-WASP Complex 63
Show member pathways
 12.33 RND2 RHOJ RAC3
4
Signaling by Rho GTPases 65
Show member pathways
 12.29 RHOV RHOJ RHOF RHOBTB2 RHOBTB1 RAC3
5
p75 NTR receptor-mediated signalling 65
Show member pathways
 11.86 RHOV RHOJ RHOF RHOBTB2 RHOBTB1 RAC3
6
Ubiquitin mediated proteolysis 36
11.62 RHOBTB2 RHOBTB1
7
Fc-GammaR Pathway 63
Show member pathways
 11.57 RND2 RAC3
8
S-1P Stimulated Signaling 63
11.48 RND2 RAC3
9
Guidance Cues and Growth Cone Motility 63
11.47 RND2 RAC3
10
Phagocytosis of Microbes 63
11.19 RND2 RAC3
11
Semaphorin Signaling 63
10.81 RND2 RAC3
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GO Terms for Ascaridiasis

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Cellular components related to Ascaridiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.91 RND2 RHOV RHOJ RHOF RHOBTB2 RHOBTB1
2 cytosol GO:0005829 9.88 RHOV RHOJ RHOF RHOBTB2 RHOBTB1 RAC3
3 cytoskeleton GO:0005856 9.72 RND2 RHOF RHOBTB2 RHOBTB1 RAC3
4 cell projection GO:0042995 9.65 RND2 RHOF RHOBTB2 RHOBTB1 RAC3
5 intracellular membrane-bounded organelle GO:0043231 9.55 RND2 RHOF RHOBTB2 RHOBTB1 RAC3
6 cytoplasmic vesicle GO:0031410 9.35 RND2 RHOF RHOBTB2 RHOBTB1 RAC3
7 cell cortex GO:0005938 9.02 RND2 RHOF RHOBTB2 RHOBTB1 RAC3

Biological processes related to Ascaridiasis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 actin filament organization GO:0007015 9.8 RND2 RHOF RHOBTB2 RHOBTB1 RAC3
2 regulation of actin cytoskeleton organization GO:0032956 9.77 RND2 RHOF RHOBTB2 RHOBTB1 RAC3
3 cell migration GO:0016477 9.76 RND2 RHOV RHOJ RHOF
4 regulation of cell shape GO:0008360 9.73 RND2 RHOJ RHOF RHOBTB2 RHOBTB1 RAC3
5 establishment or maintenance of cell polarity GO:0007163 9.72 RND2 RHOF RHOBTB2 RHOBTB1 RAC3
6 regulation of small GTPase mediated signal transduction GO:0051056 9.63 RHOV RHOJ RHOF RHOBTB2 RHOBTB1 RAC3
7 cell projection assembly GO:0030031 9.61 RHOV RHOJ RAC3
8 engulfment of apoptotic cell GO:0043652 9.49 RHOBTB2 RHOBTB1
9 Cdc42 protein signal transduction GO:0032488 9.48 RHOV RHOJ
10 cortical cytoskeleton organization GO:0030865 9.35 RND2 RHOF RHOBTB2 RHOBTB1 RAC3
11 small GTPase mediated signal transduction GO:0007264 9.17 RND2 RHOV RHOJ RHOF RHOBTB2 RHOBTB1

Molecular functions related to Ascaridiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.7 RND2 RHOV RHOJ RHOF RHOBTB2 RHOBTB1
2 protein kinase binding GO:0019901 9.65 RND2 RHOF RHOBTB2 RHOBTB1 RAC3
3 GTP binding GO:0005525 9.5 RND2 RHOV RHOJ RHOF RHOBTB2 RHOBTB1
4 GTPase activity GO:0003924 9.17 RND2 RHOV RHOJ RHOF RHOBTB2 RHOBTB1
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Sources for Ascaridiasis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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