MCID: ASC001
MIFTS: 36

Ascaridiasis

Categories: Infectious diseases

Aliases & Classifications for Ascaridiasis

MalaCards integrated aliases for Ascaridiasis:

Name: Ascaridiasis 12 44 15 17 72
Ascariasis 72

Classifications:



External Ids:

Disease Ontology 12 DOID:3108
MeSH 44 D001198
SNOMED-CT 68 2435008 76160002
UMLS 72 C0003950 C0003952

Summaries for Ascaridiasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the intestine of humans and birds with nematodes of the genus Ascaridia.

MalaCards based summary : Ascaridiasis, also known as ascariasis, is related to parasitic helminthiasis infectious disease and trichuriasis. An important gene associated with Ascaridiasis is STIMATE (STIM Activating Enhancer), and among its related pathways/superpathways are Th17 cell differentiation and Staphylococcus aureus infection. The drugs Pyrantel and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and lung.

Related Diseases for Ascaridiasis

Diseases related to Ascaridiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 parasitic helminthiasis infectious disease 30.3 STH IL13 IL10
2 trichuriasis 29.9 STH IL13 IL10
3 ascaris lumbricoides infection 10.4
4 ankylostomiasis 10.4
5 enterobiasis 10.3
6 dysbaric osteonecrosis 10.3 STH PLG
7 ancylostomiasis 10.3
8 cholangitis 10.3
9 filarial elephantiasis 10.2 STH IL10
10 conjunctival disease 10.2 PLG IL13
11 nickel allergic contact dermatitis 10.2 IL13 IL10
12 beta-lactam allergy 10.2 IL13 IL10
13 apple allergy 10.2 IL13 IL10
14 eosinophilic meningitis 10.2 IL13 IL10
15 peanut allergy 10.2 IL13 IL10
16 radiculopathy 10.2 IL13 IL10
17 mycoplasma pneumoniae pneumonia 10.2 IL13 IL10
18 lipoid nephrosis 10.2 IL13 IL10
19 diarrhea 10.2
20 obstructive jaundice 10.2
21 cholecystitis 10.2
22 necatoriasis 10.2
23 acute pancreatitis 10.2
24 pancreatitis 10.2
25 peritonitis 10.2
26 intestinal obstruction 10.2
27 hypereosinophilic syndrome 10.2
28 paranasal sinus disease 10.2 IL13 IL10
29 hyperlucent lung 10.1 NELFCD IL10
30 nasal cavity disease 10.1 IL13 IL10
31 pericardial tuberculosis 10.1 NELFCD IL10
32 nose disease 10.1 IL13 IL10
33 conjunctivitis 10.1 PLG IL13
34 respiratory allergy 10.1 IL13 IL10
35 buruli ulcer 10.1 NELFCD IL10
36 ige responsiveness, atopic 10.1 IL13 IL10
37 transient hypogammaglobulinemia of infancy 10.1 NELFCD IL10
38 hepatic vascular disease 10.0 PLG AFP
39 upper respiratory tract disease 10.0 IL13 IL10
40 hydrops, lactic acidosis, and sideroblastic anemia 10.0
41 taeniasis 10.0
42 thrombosis 10.0
43 filariasis 10.0
44 capillariasis 10.0
45 trichostrongylosis 10.0
46 lymphadenitis 10.0
47 intestinal perforation 10.0
48 parasitic protozoa infectious disease 10.0
49 cryoglobulinemia 10.0
50 linitis plastica 10.0

Graphical network of the top 20 diseases related to Ascaridiasis:



Diseases related to Ascaridiasis

Symptoms & Phenotypes for Ascaridiasis

Drugs & Therapeutics for Ascaridiasis

Drugs for Ascaridiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pyrantel Approved, Vet_approved Phase 4 15686-83-6
2 Immunologic Factors Phase 4
3 Pyrantel Pamoate Phase 4
4 Adjuvants, Immunologic Phase 4
5 Antirheumatic Agents Phase 4
6
Ivermectin Approved, Investigational, Vet_approved 70288-86-7 6474909
7
Mebendazole Approved, Vet_approved 31431-39-7 4030
8
Iodine Approved, Investigational 7553-56-2 807
9
Vitamin C Approved, Nutraceutical 50-81-7 54670067 5785
10 Micronutrients
11 Trace Elements
12 Antioxidants
13 Vitamins
14 Protective Agents
15 Nutrients
16 Anti-Bacterial Agents
17 Antibiotics, Antitubercular
18 cadexomer iodine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Longitudinal Study of Efficacy of Standard Albendazole Treatment Versus Levamisole/Pyrantel Pamoate on Soil Transmitted Helminth Infections Completed NCT00659997 Phase 4 Albendazole;Levamisole
2 A Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Impact of Anthelmintic Treatment on the Incidence of Diarrheal Disease in School Children in Southern Vietnam Withdrawn NCT02597556 Phase 4 Albendazole;Placebo
3 Efficacy and Nutritional Assessment Following Albendazole and Combined Albendazole/Ivermectin Treatment for Intestinal Helminth Infections in Rural Guatemalan Schoolchildren Completed NCT00207753 albendazole vs. combined albendazole/ivermectin treatment
4 Impact of Repeated Anthelminthic Treatment on Malaria in School Children: an Individual Randomized, Double-blind, Placebo-controlled Trial in Western Kenya Completed NCT01658774 Albendazole
5 The Sero-prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989
6 Paediatric Surgery Across Sub-Saharan Africa: A Multi-Centre Prospective Cohort Study Completed NCT03185637
7 Diagnostics of Intestinal Parasitosis in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435

Search NIH Clinical Center for Ascaridiasis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Ivermectin
Mebendazole
Pyrantel
Pyrantel Pamoate

Cochrane evidence based reviews: ascaridiasis

Genetic Tests for Ascaridiasis

Anatomical Context for Ascaridiasis

MalaCards organs/tissues related to Ascaridiasis:

41
Liver, Testes, Lung, Small Intestine, Kidney, Skin, Eye

Publications for Ascaridiasis

Articles related to Ascaridiasis:

(show top 50) (show all 2296)
# Title Authors PMID Year
1
Parasitic infections in Malaysian aborigines with pulmonary tuberculosis: a comparative cross-sectional study. 38
31363922 2019
2
Anti-Ascaris suum immunoglobulin Y as a novel biotechnological tool for the diagnosis of human ascariasis. 38
31409433 2019
3
The liver proteome in a mouse model for Ascaris suum resistance and susceptibility: evidence for an altered innate immune response. 38
31412915 2019
4
Exposure to Ascaris lumbricoides infection and risk of childhood asthma in north of Iran. 38
31350726 2019
5
Differential diagnosis of focal gallbladder lesions: The added value of contrast enhanced ultrasound with liner transducers. 38
31306115 2019
6
Old Antiprotozoal Drugs: Are They Still Viable Options for Parasitic Diseases or New Options for Other Diseases? 38
31264538 2019
7
Ascariasis as a model to study the helminth/allergy relationships. 38
30295330 2019
8
Small bowel obstruction complicating an Ascaris lumbricoides infestation in a 4-year-old male: a case report. 38
31122293 2019
9
Biological role of excretory-secretory proteins in endemic parasites of Latin America and the Caribbean. 38
31092301 2019
10
Secular Trends of Ascariasis Infestation and Nutritional Status in Chinese Children From 2000 to 2014: Evidence From 4 Successive National Surveys. 38
31139673 2019
11
[Interpretation of Diagnosis of Ascariasis (WS/565-2017)]. 38
31184060 2019
12
Ascariasis and its relationship with selected psycho-neurological symptoms among children and adults in Poland. 38
31099762 2019
13
Efficacy of Albendazole and Mebendazole With or Without Levamisole for Ascariasis and Trichuriasis. 38
31110573 2019
14
The inner tube sign in Ascariasis. 38
30498923 2019
15
Imaging of toxocariasis. 38
30861557 2019
16
Molecular analysis of human- and pig-derived Ascaris in Honduras. 38
29502555 2019
17
Ultrasonography for early diagnosis of Toxocara canis infection in puppies. 38
30706166 2019
18
Comparative analysis of excretory-secretory antigens of Anisakis simplex, Pseudoterranova decipiens and Contracaecum osculatum regarding their applicability for specific serodiagnosis of human anisakidosis based on IgG-ELISA. 38
30584924 2019
19
Predictors of therapeutic failure among patients with acute brucellosis treated by dual therapy with doxycycline-rifampin. 38
30411836 2019
20
Incidental diagnosis of appendiceal ascariasis during colonoscopy. 38
30115571 2019
21
Biliary Ascariasis Mimicking as Choledocholithiasis on Endoscopic Ultrasound. 38
30935184 2019
22
Biliary Ascariasis: An Unusual Case of Obstructive Jaundice. 38
30710698 2019
23
Children from a rural region in The Chiapas Highlands, Mexico, show an increased risk of stunting and intestinal parasitoses when compared with urban children. 38
30657470 2019
24
Never seen before? Opisthorchiasis and Clonorchiasis. 38
30466135 2018
25
Small bowel volvulus in an adult with mesenteric lymphangioma and ascariasis. 38
28266164 2018
26
Ascaris Larval Infection and Lung Invasion Directly Induce Severe Allergic Airway Disease in Mice. 38
30249744 2018
27
Differential diagnosis of gallbladder ascariasis debris: the added value of contrast enhanced ultrasound with high frequency transducer. 38
30534646 2018
28
Ascaris lumbricoides: challenges in diagnosis, treatment and prevention strategies in a European refugee camp. 38
29458300 2018
29
Ascaris lumbricoides infection induces both, reduction and increase of asthma symptoms in a rural community. 38
30040946 2018
30
An unusual finding of obstructive jaundice-a case report and review of the literature. 38
30323942 2018
31
Association of intestinal pathogens with faecal markers of environmental enteric dysfunction among slum-dwelling children in the first 2 years of life in Bangladesh. 38
30133067 2018
32
Worm Infestation: Diagnosis, Treatment and Prevention. 38
29127616 2018
33
Recurrent acute pancreatitis due to pancreatic duct ascariasis in a young man. 38
30096718 2018
34
A Worm Hole: Liver Abscess in Ascariasis. 38
29518367 2018
35
Epidemiology of soil transmitted Helminth infections in the middle-belt of Ghana, Africa. 38
29988303 2018
36
Molecular identification of Ascaris lumbricoides and Ascaris suum recovered from humans and pigs in Thailand, Lao PDR, and Myanmar. 38
29860571 2018
37
Parasite allergens. 38
29588070 2018
38
Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-Specific Immune Changes. 38
29752313 2018
39
Ascaridial Volvulus: An Uncommon Cause of Ileal Perforation. 38
30046214 2018
40
Biliary ascariasis presenting with gangrenous perforation of the gall bladder: report of a case and brief review of literature. 38
29649951 2018
41
Ascariasis Diagnosed by Wireless Capsule Endoscopy. 38
28865763 2018
42
Gastrointestinal: An unusual cause of biliary colic: Biliary ascariasis. 38
29659086 2018
43
Ascaris lumbricoides: A Startling Discovery during Screening Colonoscopy. 38
29928187 2018
44
Removal of helminth eggs by centralized and decentralized wastewater treatment plants in South Africa and Lesotho: health implications for direct and indirect exposure to the effluents. 38
29478163 2018
45
High prevalence of ascariasis on two coral atolls in the Solomon Islands. 38
29800343 2018
46
EUS of pancreatic ascariasis. 38
29523472 2018
47
Ascariasis seen by videocapsule endoscopy. 38
29222943 2018
48
Analysis of the causes of the seizure and destruction of carcasses and organs in a slaughterhouse in central Italy in the 2010-2016 period. 38
29732323 2018
49
[Epidemiological features of parasitary invasis in women of reproductive age with disorders of reproductive health]. 38
29783245 2018
50
Prevalence of intestinal parasites versus knowledge, attitude and practices (KAPs) with special emphasis to Schistosoma mansoni among individuals who have river water contact in Addiremets town, Western Tigray, Ethiopia. 38
30252865 2018

Variations for Ascaridiasis

Expression for Ascaridiasis

Search GEO for disease gene expression data for Ascaridiasis.

Pathways for Ascaridiasis

GO Terms for Ascaridiasis

Biological processes related to Ascaridiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of endothelial cell apoptotic process GO:2000352 8.96 IL13 IL10
2 positive regulation of macrophage activation GO:0043032 8.62 IL13 IL10

Molecular functions related to Ascaridiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.28 STIMATE STH PPP3R1 PLG NELFCD IL13

Sources for Ascaridiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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