MCID: ASC010
MIFTS: 49

Ascaris Lumbricoides Infection

Categories: Infectious diseases

Aliases & Classifications for Ascaris Lumbricoides Infection

MalaCards integrated aliases for Ascaris Lumbricoides Infection:

Name: Ascaris Lumbricoides Infection 57 12
Ascariasis 57 12 73 3 44 15 17 70 32
Ascaris Lumbricoides Infection, Susceptibility to 57
Ascariasis, Susceptibility to 57
Ascariasis - Roundworm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:456
OMIM® 57 604291
ICD9CM 34 127.0
MeSH 44 D001196
NCIt 50 C128392
SNOMED-CT 67 2435008
UMLS 70 C0003950

Summaries for Ascaris Lumbricoides Infection

CDC : 3 An estimated 807 million–1.2 billion people in the world are infected with Ascaris lumbricoides(sometimes called just Ascaris or ascariasis). Ascaris, hookworm, and whipworm are parasitic worms known as soil-transmitted helminths (STH). Together, they account for a major burden of parasitic disease worldwide. Ascariasis is now uncommon in the United States. Ascaris parasites live in the intestine and Ascaris eggs are passed in the feces (poop) of infected people. If an infected person defecates outside (for example, near bushes, in a garden, or in a field), or if the feces of an infected person are used as fertilizer, eggs are deposited on soil. The eggs can then mature into a form of the parasite that is infective. Ascariasis is caused by ingesting eggs. This can happen when hands or fingers that have contaminated dirt on them are put in the mouth, or by consuming vegetables or fruits that have not been carefully cooked, washed, or peeled. People infected with Ascaris often show no symptoms. If symptoms do occur they can be light and include abdominal discomfort. Heavy infections can cause intestinal blockage and impair growth in children. Other symptoms such as cough are due to migration of the worms through the body. Ascariasis is treatable with medication prescribed by your health care provider. Humans can also be infected by pig roundworm (Ascaris suum). Ascaris lumbricoides (human roundworm) and Ascaris suum (pig roundworm) are indistinguishable. It is unknown how many people worldwide are infected with Ascaris suum.

MalaCards based summary : Ascaris Lumbricoides Infection, also known as ascariasis, is related to ige responsiveness, atopic and taeniasis. An important gene associated with Ascaris Lumbricoides Infection is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Pyrantel and Levamisole have been mentioned in the context of this disorder. Affiliated tissues include liver, spleen and bone, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the intestine with the nematode Ascaris lumbricoides. Larvae migrating through the lungs cause cough, wheezing and hemoptysis. Bowel or biliary obstruction causes cramping abdominal pain, nausea, and vomiting. Peritonitis, enlargement of the liver or spleen, toxicity and pneumonia are observed when larvae get into the portal circulation.

OMIM® : 57 More than a quarter of the human population is affected by soil-transmitted helminthes, which impair nutrition and the immune response to widespread pandemics, such as acquired immunodeficiency syndrome (see 609423) and tuberculosis (see 607948). The roundworm Ascaris lumbricoides, the most common human parasite of the gastrointestinal tract, causes ascariasis, which has a worldwide distribution with highest prevalence in tropical and subtropical regions and in areas with inadequate sanitation. Ascariasis is triggered by ingestion of parasite eggs. During its life cycle, Ascaris threatens human health with nonspecific abdominal symptoms, intestinal obstruction and perforation, biliary colic, gallstone formation, liver abscesses, pancreatitis, and pulmonary eosinophilia (Sanglas et al., 2009). (604291) (Updated 20-May-2021)

Wikipedia : 73 Ascariasis is a disease caused by the parasitic roundworm Ascaris lumbricoides. Infections have no... more...

Related Diseases for Ascaris Lumbricoides Infection

Diseases related to Ascaris Lumbricoides Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 537)
# Related Disease Score Top Affiliating Genes
1 ige responsiveness, atopic 30.7 IL5 IL13 IFNG
2 taeniasis 30.7 IL6 IL5 IL13
3 appendicitis 30.6 IL6 IL1B IFNG CXCL8
4 echinococcosis 30.5 IL6 IL5 IFNG
5 strongyloidiasis 30.5 IL5 IL13 IFNG
6 acute pancreatitis 30.5 SERPINA3 IL6 IL1B CXCL8
7 hypereosinophilic syndrome 30.4 IL5 IL13 IFNG CXCL8
8 cysticercosis 30.4 IL6 IL5 IL1B
9 cytokine deficiency 30.4 IL5 IL13
10 schistosomiasis 30.4 IL5 IL13 IFNG
11 dysentery 30.4 IL6 IL1B CXCL8
12 typhoid fever 30.3 IL6 IL1B IFNG
13 urticaria 30.3 IL6 IL5 IL13 CXCL8
14 filariasis 30.2 IL7 IL6 IL5 IFNG
15 allergic rhinitis 30.2 IL5 IL13 IFNG CXCL8
16 peritonitis 30.2 IL6 IL1B CXCL8
17 trichinosis 30.2 TSLP IL5 IL13
18 rhinitis 30.0 TSLP IL6 IL5 IL13 IFNG CXCL8
19 diphtheria 30.0 IL5 IL1B IL13
20 eosinophilic pneumonia 29.9 IL5 IL13 CXCL8
21 parasitic helminthiasis infectious disease 29.8 TSLP SERPINA3 IL6 IL5 IL1B IL13
22 wells syndrome 29.8 IL5 IL1B CXCL8
23 peptic esophagitis 29.8 IL6 IL1B CXCL8
24 duodenal ulcer 29.7 IL6 IL1B CXCL8
25 diarrhea 29.7 IL6 IL5 IL1B IL13 IFNG CXCL8
26 dermatitis 29.7 TSLP IL6 IL5 IL1B IL13 IFNG
27 allergic disease 29.7 TSLP IL6 IL5 IL1B IL13 IFNG
28 disease by infectious agent 29.7 SERPINA3 IL7 IL6 IL1B IFNG
29 syphilis 29.7 SERPINA3 IL6 IFNG
30 viral hepatitis 29.7 SERPINA3 IL6 IL1B IFNG
31 opisthorchiasis 29.6 SERPINA3 IL1B CXCL8
32 salmonellosis 29.6 IL6 IL1B IFNG CXCL8
33 chagas disease 29.6 IL6 IL1B IFNG CXCL8
34 neuritis 29.5 IL6 IL1B IFNG CXCL8
35 myocarditis 29.5 IL6 IL1B IFNG
36 dermatitis, atopic 29.4 TSLP SERPINA3 IL6 IL5 IL1B IL13
37 allergic asthma 29.4 TSLP IL5 IL13 IFNG CXCL8
38 bacterial pneumonia 29.4 SERPINA3 IL6 IL1B CXCL8
39 otitis media 29.4 IL6 IL5 IL1B IFNG CXCL8
40 erythema nodosum 29.4 IL6 IL1B IL13 IFNG CXCL8
41 crohn's disease 29.4 IL6 IL1B IL13 IFNG CXCL8
42 middle ear disease 29.2 SERPINA3 IL6 IL5 IL1B CXCL8
43 bacterial infectious disease 29.2 SERPINA3 IL6 IL1B IFNG CXCL8
44 meningitis 29.2 IL6 IL5 IL1B IL13 IFNG CXCL8
45 celiac disease 1 29.2 IL6 IL5 IL1B IL13 IFNG CXCL8
46 malaria 29.2 TNFSF13B SERPINA3 IL7 IL6 IL5 IL1B
47 esophagitis 29.2 TSLP IL6 IL5 IL1B IL13 CXCL8
48 gastroenteritis 29.1 TSLP IL6 IL5 IL1B IFNG CXCL8
49 asthma 29.1 TSLP SERPINA3 IL7 IL6 IL5 IL1B
50 respiratory failure 29.0 SERPINA3 IL6 IL5 IL1B IL13 CXCL8

Graphical network of the top 20 diseases related to Ascaris Lumbricoides Infection:



Diseases related to Ascaris Lumbricoides Infection

Symptoms & Phenotypes for Ascaris Lumbricoides Infection

Clinical features from OMIM®:

604291 (Updated 20-May-2021)

MGI Mouse Phenotypes related to Ascaris Lumbricoides Infection:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 COPS7A IFNG IL13 IL1B IL5 IL6
2 immune system MP:0005387 9.36 COPS7A IFNG IL13 IL1B IL5 IL6

Drugs & Therapeutics for Ascaris Lumbricoides Infection

Drugs for Ascaris Lumbricoides Infection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pyrantel Approved, Vet_approved Phase 4 15686-83-6
2
Levamisole Approved, Investigational, Vet_approved, Withdrawn Phase 4 14769-73-4 26879
3 Adjuvants, Immunologic Phase 4
4 Antirheumatic Agents Phase 4
5 Immunologic Factors Phase 4
6 Pyrantel Pamoate Phase 4
7
Albendazole Approved, Vet_approved Phase 2, Phase 3 54965-21-8 2082
8
Ivermectin Approved, Investigational, Vet_approved Phase 2, Phase 3 70288-86-7 6474909
9 Tubulin Modulators Phase 2, Phase 3
10 Antimitotic Agents Phase 2, Phase 3
11 Antiparasitic Agents Phase 2, Phase 3
12 Antiprotozoal Agents Phase 2, Phase 3
13 Anthelmintics Phase 2, Phase 3
14 Anti-Infective Agents Phase 2, Phase 3
15 Milbemycin Phase 2, Phase 3
16
Mebendazole Approved, Vet_approved 31431-39-7 4030
17
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067
18 Micronutrients
19 Trace Elements
20 Nutrients
21 Antioxidants
22 Vitamins
23 Protective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Longitudinal Study of Efficacy of Standard Albendazole Treatment Versus Levamisole/Pyrantel Pamoate on Soil Transmitted Helminth Infections Completed NCT00659997 Phase 4 Albendazole;Levamisole
2 Efficacy and Safety of Moxidectin and Albendazole Compared to Ivermectin and Albendazole Co-administration in Adolescents Infected With Trichuris Trichiura: a Randomized Controlled Trial Not yet recruiting NCT04700423 Phase 2, Phase 3 moxidectin (8 mg) / albendazole (400 mg);ivermectin (200 µg/kg) / albendazole (400 mg);ALBENDAZOLE 400 Mg ORAL TABLET [ZENTEL];ivermectin (200 µg/kg);moxidectin (8 mg)
3 Efficacy and Safety of Combination Moxidectin and Albendazole, Ivermectin and Albendazole and Albendazole Alone in Adolescents and Adults Infected With Trichuris Trichiura: a Randomized Controlled Trial Not yet recruiting NCT04726969 Phase 3 Moxidectin 2 mg Oral Tablet;Albendazole 400 mg Oral Tablet;Ivermectin 3 mg Oral Tablet
4 The Sero-prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989
5 Efficacy and Nutritional Assessment Following Albendazole and Combined Albendazole/Ivermectin Treatment for Intestinal Helminth Infections in Rural Guatemalan Schoolchildren Completed NCT00207753 albendazole vs. combined albendazole/ivermectin treatment
6 Impact of Repeated Anthelminthic Treatment on Malaria in School Children: an Individual Randomized, Double-blind, Placebo-controlled Trial in Western Kenya Completed NCT01658774 Albendazole
7 Re-infection Rates of Soil-transmitted Helminth Infections Among School-aged Children Following a Single or a 4-monthly Health Hygiene Education: an Open Label Clinical Trial Active, not recruiting NCT04227834

Search NIH Clinical Center for Ascaris Lumbricoides Infection

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Ivermectin
Mebendazole
Pyrantel
Pyrantel Pamoate

Cochrane evidence based reviews: ascariasis

Genetic Tests for Ascaris Lumbricoides Infection

Anatomical Context for Ascaris Lumbricoides Infection

MalaCards organs/tissues related to Ascaris Lumbricoides Infection:

40
Liver, Spleen, Bone, Skin, Lung, Eye, Small Intestine

Publications for Ascaris Lumbricoides Infection

Articles related to Ascaris Lumbricoides Infection:

(show top 50) (show all 2321)
# Title Authors PMID Year
1
Genetic analysis of susceptibility to infection with Ascaris lumbricoides. 57 61
10403321 1999
2
Ascariasis: a family disease. 57 61
4826619 1974
3
Mammalian metallopeptidase inhibition at the defense barrier of Ascaris parasite. 57
19179285 2009
4
A possible genetic factor influencing protection from infection with Ascaris lumbricoides in Nigerian children. 57
1403439 1992
5
Clustering of Ascaris lumbricoides and Trichuris trichiura infections within households. 57
3188157 1988
6
Massive biliary ascariasis: an unusual cause of acute cholangitis. 61
33762275 2021
7
Treatment response and long-term outcomes in biliary ascariasis: A prospective study. 61
33752976 2021
8
Trilateral Relationship: Ascaris, Microbiota, and Host Cells. 61
33008723 2021
9
The Effect of Drug Pricing on Outpatient Payments and Treatment for Three Soil-Transmitted Helminth Infections in the United States, 2010-2017. 61
33684066 2021
10
Evaluation of crude adult Ascaris suum intestinal tract homogenate in inducing protective IgG production against A. suum larvae in BALB/c mice. 61
33307097 2021
11
The mitochondrial genome of the sheep roundworm Ascaris ovis (Ascaridida: Nematoda) from Southwest China. 61
33659695 2021
12
Helminth-derived cystatins: the immunomodulatory properties of an Ascaris lumbricoides cystatin. 61
33563346 2021
13
Intestinal Obstruction in a Child with Massive Ascariasis. 61
33505753 2021
14
Traditional herbal medicine therapy of gallbladder ascariasis: a case report. 61
33514402 2021
15
Vaccination with chimeric protein induces protection in murine model against ascariasis. 61
33248854 2021
16
A Rare Case of Ascariasis-Induced Cholangitis Complicated With Klebsiella pneumoniae Bacteremia and Liver Microabscesses. 61
33564511 2021
17
Prevalence of Intestinal Parasites and Salmonella typhi among Food Handlers Working in Catering Establishments of Public Institutes Found in Dawuro Zone, South-Western Ethiopia. 61
33510904 2021
18
Triterpenoid and Saponin Rich Phytolacca dodecandra L'Herit (Endod): A Review on Its Phytochemistry and Pharmacological Properties. 61
32552643 2021
19
Socioenvironmental Factors Influencing Distribution and Intensity of Soil-Transmitted Helminthiasis in the Brazilian Amazon: Challenges for the 2030 Agenda. 61
33613673 2021
20
Genomic Signatures of Coevolution between Nonmodel Mammals and Parasitic Roundworms. 61
32960966 2021
21
Cluster of Parasite Infections by the Spatial Scan Analysis in Korea. 61
33412763 2020
22
A unique cause of chronic abdominal pain. 61
33319064 2020
23
Ascariasis, Amebiasis and Giardiasis in Mexican children: distribution and geographical, environmental and socioeconomic risk factors. 61
33177788 2020
24
Quantitative lipidomic analysis of Ascaris suum. 61
33264279 2020
25
Ascaris Lumbricoides Infestation as an Unexpected Cause of Acute Pancreatitis. 61
33489520 2020
26
Hidden Nematode Causing Recurrent Pancreatitis: A Case Report. 61
33409075 2020
27
Prevalence of Ascaris lumbricoides in contaminated faecal samples of children residing in urban areas of Lahore, Pakistan. 61
33311542 2020
28
Molecular evidence of hybridization between pig and human Ascaris indicates an interbred species complex infecting humans. 61
33155980 2020
29
[Ascariasis in the intrahepatic biliary duct: about a case in pediatrics]. 61
32924404 2020
30
Detection of Ascaris lumbricoides infection by ABA-1 coproantigen ELISA. 61
33057357 2020
31
Loop-Mediated Isothermal Amplification as Point-of-Care Diagnosis for Neglected Parasitic Infections. 61
33126446 2020
32
S-Methyl-(2-Methoxycarbonylamino-Benzimidazole-5) Thiosulfonate as a Potential Antiparasitic Agent-Its Action on the Development of Ascaris suum Eggs In Vitro. 61
33113959 2020
33
Ascaris-mimicking common bile duct stone: A case report. 61
33083410 2020
34
2-Methyl-pentanoyl-carnitine (2-MPC): a urine biomarker for patent Ascaris lumbricoides infection. 61
32978457 2020
35
Mitochondrial phylogenomics of human-type Ascaris, pig-type Ascaris, and hybrid Ascaris populations. 61
33053491 2020
36
A first nation-wide assessment of soil-transmitted helminthiasis in Fijian primary schools, and factors associated with the infection, using a lymphatic filariasis transmission assessment survey as surveillance platform. 61
32976499 2020
37
Ascariasis in common bile duct resulting in a subhepatic abscess. 61
33094600 2020
38
Soil-transmitted helminthiasis: A neglected tropical disease among urban slum dwelling school-aged children of a sub-Saharan African city. 61
32687117 2020
39
Biliary Ascariasis: An Unusual Case of Obstructive Jaundice. 61
30710698 2020
40
Biliary ascariasis and severe bacterial outcomes: Report of three cases from a paediatric hospital in Brazil. 61
32240824 2020
41
Interactions between helminths and tuberculosis infections: Implications for tuberculosis diagnosis and vaccination in Africa. 61
32498074 2020
42
Fungal and Parasitic Infections of the Liver. 61
32389369 2020
43
Performance of two serodiagnostic tests for loiasis in a Non-Endemic area. 61
32453734 2020
44
Pictorial Review of Thoracic Parasitic Diseases: A Radiologic Guide. 61
31978430 2020
45
Whipworm and roundworm infections. 61
32467581 2020
46
Anthelmintic drugs for treating ascariasis. 61
32289194 2020
47
Pro-fibrinolytic potential of the third larval stage of Ascaris suum as a possible mechanism facilitating its migration through the host tissues. 61
32312291 2020
48
Imported Infections in Rural Mid-West United States - A Report from a Tertiary Care Center. 61
32308221 2020
49
Study on the population evolution of Ascaris lumbricoides and Ascaris suum based on whole genome resequencing. 61
32126343 2020
50
Biliary ascariasis: particular cause of biliary tract infection. 61
32140497 2020

Variations for Ascaris Lumbricoides Infection

Expression for Ascaris Lumbricoides Infection

Search GEO for disease gene expression data for Ascaris Lumbricoides Infection.

Pathways for Ascaris Lumbricoides Infection

Pathways related to Ascaris Lumbricoides Infection according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 TNFSF13B SERPINA3 IRS2 IL7 IL6 IL5
2
Show member pathways
13.78 TNFSF13B IRS2 IL7 IL6 IL5 IL1B
3
Show member pathways
13.62 TSLP TNFSF13B IL7 IL6 IL5 IL1B
4
Show member pathways
13.47 TNFSF13B IRS2 IL7 IL6 IL5 IL1B
5
Show member pathways
13.37 TNFSF13B IL7 IL6 IL5 IL1B IL13
6
Show member pathways
13.27 TNFSF13B IRS2 IL7 IL6 IL5 IL1B
7
Show member pathways
13.26 TNFSF13B IL7 IL6 IL5 IL1B IL13
8 12.8 IL7 IL6 IL5 IL13 IFNG CXCL8
9
Show member pathways
12.78 TNFSF13B IL6 IL5 IL1B IL13 IFNG
10
Show member pathways
12.57 IL6 IL5 IL1B IL13 IFNG
11
Show member pathways
12.55 IRS2 IL6 IL1B IFNG
12
Show member pathways
12.33 TSLP IL7 IL6 IL5 IL13 IFNG
13
Show member pathways
12.31 SERPINA3 IL6 IL1B IFNG
14
Show member pathways
12.29 IL6 IL1B IFNG CXCL8
15
Show member pathways
12.24 IL6 IL5 IL1B IL13 IFNG CXCL8
16
Show member pathways
12.22 IL6 IL5 IL1B IL13 IFNG CXCL8
17
Show member pathways
12.17 IL6 IL1B IFNG CXCL8
18 12.15 IL6 IL1B IL13 CXCL8
19 11.99 IL7 IL6 IL5 IFNG
20 11.98 IL6 IL1B IL13 CXCL8
21 11.95 TNFSF13B IL6 IL1B IFNG CXCL8
22 11.93 IL6 IL1B IFNG CXCL8
23 11.9 TNFSF13B IL1B CXCL8
24 11.9 IL6 IL1B IFNG CXCL8
25 11.88 IL6 IL1B CXCL8
26 11.88 IL7 IL6 IL5 IL1B
27
Show member pathways
11.84 IL6 IL1B IFNG
28 11.84 IRS2 IL6 IFNG
29 11.8 TNFSF13B IL6 IL1B IFNG CXCL8
30
Show member pathways
11.75 IL6 IL1B IFNG
31 11.75 IL6 IL1B CXCL8
32
Show member pathways
11.74 IL5 IFNG CXCL8
33 11.73 IL6 IL1B IFNG
34 11.68 IL6 IL5 IL13 IFNG CXCL8
35 11.67 TNFSF13B IL6 IL5
36
Show member pathways
11.67 IL6 IL1B IFNG CXCL8
37 11.6 IL6 IL1B CXCL8
38 11.59 IL6 IFNG CXCL8
39 11.55 IL6 IL1B IFNG CXCL8
40 11.54 TSLP IL7 IL5 IL1B IL13 IFNG
41 11.53 IL6 IL1B IL13 CXCL8
42 11.52 IL6 IL5 IL1B
43 11.52 IL6 IL5 IL1B IL13 CXCL8
44 11.51 TSLP IL6 CXCL8
45 11.5 IL5 IL13 IFNG
46 11.48 IL6 IL1B IFNG
47 11.38 IL6 IL1B IFNG
48 11.2 IL5 IL13 IFNG
49 10.97 TNFSF13B IL7 IL6 IL5 IL1B IL13
50 10.9 IL7 IL6 IL5 IL1B IL13 IFNG

GO Terms for Ascaris Lumbricoides Infection

Cellular components related to Ascaris Lumbricoides Infection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 TSLP TNFSF13B SERPINA3 IL7 IL6 IL5
2 extracellular space GO:0005615 9.32 TSLP TNFSF13B SERPINA3 IL7 IL6 IL5
3 muscle thin filament tropomyosin GO:0005862 9.16 TPM4 TPM2

Biological processes related to Ascaris Lumbricoides Infection according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.18 TSLP TNFSF13B IRS2 IL7 IL6 IL5
2 positive regulation of gene expression GO:0010628 9.95 IL7 IL6 IL1B IL13 IFNG CXCL8
3 positive regulation of cell proliferation GO:0008284 9.87 TSLP IRS2 IL7 IL6 IL5 IL1B
4 inflammatory response GO:0006954 9.85 SERPINA3 IL6 IL5 IL1B IL13 CXCL8
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.79 IL6 IL5 IL1B
6 positive regulation of inflammatory response GO:0050729 9.78 TSLP IL1B IFNG
7 regulation of insulin secretion GO:0050796 9.76 IL6 IL1B IFNG
8 positive regulation of interleukin-6 production GO:0032755 9.76 TSLP IL6 IL1B IFNG
9 positive regulation of T cell proliferation GO:0042102 9.73 TNFSF13B IL6 IL1B
10 cytokine-mediated signaling pathway GO:0019221 9.73 IL7 IL6 IL5 IL1B IL13 CXCL8
11 humoral immune response GO:0006959 9.72 IL7 IL6 IFNG
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 TSLP IL6 IL13 IFNG
13 positive regulation of interleukin-10 production GO:0032733 9.7 TSLP IL6 IL13
14 interleukin-7-mediated signaling pathway GO:0038111 9.67 TSLP IRS2 IL7
15 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 IL1B IFNG
16 positive regulation of immunoglobulin production GO:0002639 9.61 IL6 IL5 IL13
17 positive regulation of neuroinflammatory response GO:0150078 9.6 IL6 IL1B
18 positive regulation of cytokine-mediated signaling pathway GO:0001961 9.59 TSLP IL7
19 vascular endothelial growth factor production GO:0010573 9.57 IL6 IL1B
20 immune response GO:0006955 9.56 TNFSF13B IL7 IL6 IL5 IL1B IL13
21 positive regulation of STAT cascade GO:1904894 9.54 TSLP IL6
22 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.51 IL1B IFNG
23 positive regulation of chemokine production GO:0032722 9.46 TSLP IL7 IL6 IFNG
24 positive regulation of B cell proliferation GO:0030890 9.02 TNFSF13B IRS2 IL7 IL5 IL13

Molecular functions related to Ascaris Lumbricoides Infection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 TSLP TNFSF13B IL7 IL6 IL5 IL1B
2 interleukin-7 receptor binding GO:0005139 8.96 TSLP IL7

Sources for Ascaris Lumbricoides Infection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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