MCID: ASC010
MIFTS: 46

Ascaris Lumbricoides Infection

Categories: Infectious diseases

Aliases & Classifications for Ascaris Lumbricoides Infection

MalaCards integrated aliases for Ascaris Lumbricoides Infection:

Name: Ascaris Lumbricoides Infection 57 12
Ascariasis 57 12 76 3 44 15 73
Ascaris Lumbricoides Infection, Susceptibility to 57
Ascariasis, Susceptibility to 57
Ascariasis - Roundworm 12

Classifications:



External Ids:

OMIM 57 604291
Disease Ontology 12 DOID:456
ICD9CM 35 127.0
MeSH 44 D001196
UMLS 73 C0003950

Summaries for Ascaris Lumbricoides Infection

OMIM : 57 More than a quarter of the human population is affected by soil-transmitted helminthes, which impair nutrition and the immune response to widespread pandemics, such as acquired immunodeficiency syndrome (see 609423) and tuberculosis (see 607948). The roundworm Ascaris lumbricoides, the most common human parasite of the gastrointestinal tract, causes ascariasis, which has a worldwide distribution with highest prevalence in tropical and subtropical regions and in areas with inadequate sanitation. Ascariasis is triggered by ingestion of parasite eggs. During its life cycle, Ascaris threatens human health with nonspecific abdominal symptoms, intestinal obstruction and perforation, biliary colic, gallstone formation, liver abscesses, pancreatitis, and pulmonary eosinophilia (Sanglas et al., 2009). (604291)

MalaCards based summary : Ascaris Lumbricoides Infection, also known as ascariasis, is related to dermatitis and dermatitis, atopic. An important gene associated with Ascaris Lumbricoides Infection is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include liver, spleen and lung, and related phenotypes are growth/size/body region and digestive/alimentary

CDC : 3 An estimated 807 million–1.2 billion people in the world are infected with Ascaris lumbricoides (sometimes called just Ascaris or ascariasis). Ascaris, hookworm, and whipworm are parasitic worms known as soil-transmitted helminths (STH). Together, they account for a major burden of parasitic disease worldwide. Ascariasis is now uncommon in the United States.

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the intestine with the nematode Ascaris lumbricoides. Larvae migrating through the lungs cause cough, wheezing and hemoptysis. Bowel or biliary obstruction causes cramping abdominal pain, nausea, and vomiting. Peritonitis, enlargement of the liver or spleen, toxicity and pneumonia are observed when larvae get into the portal circulation.

Wikipedia : 76 Ascariasis is a disease caused by the parasitic roundworm Ascaris lumbricoides. Infections have no... more...

Related Diseases for Ascaris Lumbricoides Infection

Diseases related to Ascaris Lumbricoides Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 dermatitis 29.8 IL13 IL5 TSLP
2 dermatitis, atopic 29.7 IL13 IL5 TSLP
3 asthma 27.6 IL13 IL1B IL5 IL6 TSLP
4 ascaridiasis 11.3
5 cercarial dermatitis 10.5 IL1B IL5
6 gastrointestinal allergy 10.5 IL5 TSLP
7 kimura disease 10.5 IL5 TSLP
8 cytokine deficiency 10.4 IL13 IL5
9 respiratory syncytial virus infectious disease 10.4 IL13 IL5
10 wells syndrome 10.4 IL1B IL5
11 inflammatory bowel disease 4 10.4 IL13 IL5
12 paragonimiasis 10.4 IL13 IL5
13 angiostrongyliasis 10.4 IL13 IL5
14 strongyloidiasis 10.4 IL13 IL5
15 apple allergy 10.4 IL13 IL5
16 latex allergy 10.4 IL13 IL5
17 eosinophilic meningitis 10.4 IL13 IL5
18 intestinal schistosomiasis 10.4 IL13 IL5
19 urinary schistosomiasis 10.4 IL13 IL5
20 eosinophilic gastritis 10.4 IL13 IL5
21 chronic tic disorder 10.4 IL13 IL5
22 vernal keratoconjunctivitis 10.4 IL13 IL5
23 pollen allergy 10.3 IL13 IL5
24 conjunctival disease 10.3 IL13 IL5
25 night blindness, congenital stationary, type 1a 10.3 IL13 IL5
26 enterobiasis 10.3 IL13 IL5
27 cryoglobulinemia 10.3 TNFSF13B TSLP
28 pulmonary eosinophilia 10.3 IL13 IL5
29 paranasal sinus disease 10.3 IL13 IL5
30 eosinophilic pneumonia 10.3 IL13 IL5
31 onchocerciasis 10.2 IL13 IL5
32 allergic conjunctivitis 10.2 IL13 IL5
33 actinic prurigo 10.2 IL13 IL1B
34 chronic eosinophilic pneumonia 10.2 IL5 IL6
35 multicentric castleman disease 10.1 IL5 IL6
36 mesenteric lymphadenitis 10.1 IL5 IL6
37 interstitial nephritis 10.0
38 pancreatitis 10.0
39 b-cell growth factor 10.0 IL6 IL7
40 papillary conjunctivitis 10.0 IL6 IL7
41 acute monoblastic leukemia 10.0 IL6 IL7
42 recurrent corneal erosion 10.0 IL1B IL6
43 periodontitis, chronic 10.0 IL1B IL6
44 uremic pruritus 9.9 IL1B IL6
45 funisitis 9.9 IL1B IL6
46 glossitis 9.9 IL1B IL6
47 euthyroid sick syndrome 9.9 IL1B IL6
48 laryngitis 9.9 IL1B IL6
49 acute vascular insufficiency of intestine 9.9 IL1B IL6
50 poems syndrome 9.9 IL1B IL6

Graphical network of the top 20 diseases related to Ascaris Lumbricoides Infection:



Diseases related to Ascaris Lumbricoides Infection

Symptoms & Phenotypes for Ascaris Lumbricoides Infection

Clinical features from OMIM:

604291

MGI Mouse Phenotypes related to Ascaris Lumbricoides Infection:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.7 IL5 IL6 IRS2 LIG4 TSLP IL13
2 digestive/alimentary MP:0005381 9.65 IL6 LIG4 TSLP IL13 IL5
3 hematopoietic system MP:0005397 9.56 IL6 IL7 LIG4 TNFSF13B TSLP IL13
4 immune system MP:0005387 9.28 IL6 IL7 IRS2 LIG4 TNFSF13B TSLP

Drugs & Therapeutics for Ascaris Lumbricoides Infection

Search Clinical Trials , NIH Clinical Center for Ascaris Lumbricoides Infection

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: ascariasis

Genetic Tests for Ascaris Lumbricoides Infection

Anatomical Context for Ascaris Lumbricoides Infection

MalaCards organs/tissues related to Ascaris Lumbricoides Infection:

41
Liver, Spleen, Lung, T Cells

Publications for Ascaris Lumbricoides Infection

Articles related to Ascaris Lumbricoides Infection:

(show all 24)
# Title Authors Year
1
Sources of variability in the measurement of Ascaris lumbricoides infection intensity by Kato-Katz and qPCR. ( 28545561 )
2017
2
Effect of Ascaris lumbricoides infection on T helper cell type 2 in rural Egyptian children. ( 27022269 )
2016
3
Ascaris lumbricoides Infection Following School-Based Deworming in Western Kenya: Assessing the Role of Pupils' School and Home Water, Sanitation, and Hygiene Exposures. ( 26903608 )
2016
4
FACTORS ASSOCIATED WITH THE PREVALENCE OF ASCARIS LUMBRICOIDES INFECTION AMONG PRESCHOOL CHILDREN IN A PLANTATION COMMUNITY, KANDY DISTRICT, SRI LANKA. ( 29634161 )
2016
5
A Cross-Sectional Study of Ascaris lumbricoides Infection in a Rural Community in Ebonyi State, Nigeria: Prevalence and Risk Factors. ( 26576362 )
2015
6
Ascaris lumbricoides infection in urban schoolchildren: specific IgE and IL-10 production. ( 23648101 )
2014
7
Ascaris lumbricoids Infection as a Risk Factor for Asthma and Atopy in Rural Bangladeshi Children. ( 25237284 )
2014
8
Detecting and Accommodating Outliers in Meta-Analysis for Evaluating Effect of Albendazole on Ascaris lumbricoides Infection. ( 25031857 )
2014
9
Ascaris lumbricoides infection and parasite load are associated with asthma in children. ( 25022300 )
2014
10
Ascaris lumbricoides infection and its relation to environmental factors in the Mbeya region of Tanzania, a cross-sectional, population-based study. ( 24643023 )
2014
11
Diagnosis of Ascaris lumbricoides infection using capsule endoscopy. ( 23596544 )
2013
12
Coincident diagnosis of a pulmonary abscess and ascaris lumbricoides infection: a possible causal connection? ( 22821292 )
2012
13
Severity of atopic dermatitis and Ascaris lumbricoides infection: an evaluation of CCR4+ and CXCR3+ helper T cell frequency. ( 23295884 )
2012
14
Differential changes in expression of intestinal antimicrobial peptide genes during Ascaris lumbricoides infection in Zambian adults do not respond to helminth eradication. ( 21357944 )
2011
15
Analysis of clinical symptoms and selected hematological indices in hospitalized children with Ascaris lumbricoides infection from the northeastern region of Poland. ( 21634234 )
2011
16
Changes in plasma cytokines after treatment of ascaris lumbricoides infection in individuals with HIV-1 infection. ( 20441516 )
2010
17
Ascaris lumbricoides infection causing respiratory distress after coronary artery bypass grafting. ( 19803729 )
2010
18
Ascaris lumbricoides infection: an unexpected cause of pancreatitis in a western Mediterranean country. ( 20795455 )
2010
19
Association between total immunoglobulin E and antibody responses to naturally acquired Ascaris lumbricoides infection and polymorphisms of immune system-related LIG4, TNFSF13B and IRS2 genes. ( 19604268 )
2009
20
Antibody responses and resistance against Ascaris lumbricoides infection among Venezuelan rural children: the influence of ethnicity. ( 18453627 )
2008
21
Intermittent obstruction of jejunostomy tube due to Ascaris lumbricoides infection. ( 18475230 )
2008
22
Hookworm, Ascaris lumbricoides infection and polyparasitism associated with poor cognitive performance in Brazilian schoolchildren. ( 18627581 )
2008
23
Acute interstitial nephritis in a case of Ascaris lumbricoides infection. ( 15150358 )
2004
24
Should postpapillotomy screening for Ascaris lumbricoides infection be routine in communities endemic for ascariasis? ( 10445590 )
1999

Variations for Ascaris Lumbricoides Infection

Expression for Ascaris Lumbricoides Infection

Search GEO for disease gene expression data for Ascaris Lumbricoides Infection.

Pathways for Ascaris Lumbricoides Infection

Pathways related to Ascaris Lumbricoides Infection according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 IL13 IL1B IL5 IL6 IL7 IRS2
2
Show member pathways
13.62 IL13 IL1B IL5 IL6 IL7 IRS2
3
Show member pathways
13.43 IL13 IL1B IL5 IL6 IL7 TNFSF13B
4
Show member pathways
13.24 IL13 IL1B IL5 IL6 IL7 IRS2
5
Show member pathways
13.19 IL13 IL1B IL5 IL6 IL7 TNFSF13B
6
Show member pathways
13.09 IL13 IL1B IL5 IL6 IL7 IRS2
7
Show member pathways
13.07 IL13 IL1B IL5 IL6 IL7 TNFSF13B
8
Show member pathways
12.67 IL13 IL1B IL5 IL6 TNFSF13B
9 12.64 IL13 IL5 IL6 IL7
10
Show member pathways
12.33 IL13 IL1B IL5 IL6 IL7 TSLP
11
Show member pathways
12.28 IL13 IL1B IL5 IL6
12
Show member pathways
12.26 IL13 IL1B IL5
13
Show member pathways
12.25 IL1B IL5 IL6
14
Show member pathways
12.14 IL13 IL1B IL5 IL6
15 12.02 IL13 IL1B IL6
16
Show member pathways
11.89 IL13 IL1B IL5
17 11.86 IL1B IL6 TNFSF13B
18 11.84 IL5 IL6 IL7
19 11.82 IL13 IL1B IL6
20
Show member pathways
11.81 IL13 IL1B IL5 IL6 IL7 TNFSF13B
21 11.71 IL1B IL6 TNFSF13B
22 11.69 IL1B IL5 IL6 IL7
23 11.67 IL13 IL5 IL6
24 11.47 IL13 IL1B IL5 IL6
25 11.46 IL13 IL1B IL5 IL7 TSLP
26 11.36 IL13 IL1B IL6
27 11.35 IL6 TSLP
28 11.34 IL13 IL5
29 11.33 IL1B IL5 IL6
30 11.32 IL1B IL6
31 11.2 IL1B IL6
32 11.2 IL1B IL6
33 11.19 IL1B IL6
34 11.13 IL1B IL6
35 11.05 IL13 IL5
36 10.98 IL6 IRS2
37 10.83 IL13 IL1B IL5 IL6 IL7
38 10.61 IL13 IL1B IL5 IL6 IL7 TSLP

GO Terms for Ascaris Lumbricoides Infection

Cellular components related to Ascaris Lumbricoides Infection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 IL13 IL1B IL5 IL6 IL7 TNFSF13B
2 extracellular space GO:0005615 9.17 IL13 IL1B IL5 IL6 IL7 TNFSF13B

Biological processes related to Ascaris Lumbricoides Infection according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.84 IL13 IL1B IL5 IL6
2 MAPK cascade GO:0000165 9.74 IL1B IL5 IRS2
3 immune response GO:0006955 9.73 IL13 IL1B IL5 IL6 IL7 TNFSF13B
4 cytokine-mediated signaling pathway GO:0019221 9.72 IL13 IL1B IL5 IL6 IL7
5 positive regulation of cell proliferation GO:0008284 9.7 IL1B IL5 IL6 IL7 IRS2 TNFSF13B
6 positive regulation of DNA binding transcription factor activity GO:0051091 9.69 IL1B IL5 IL6
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 IL13 IL6 TSLP
8 positive regulation of T cell proliferation GO:0042102 9.63 IL1B IL6 TNFSF13B
9 positive regulation of interleukin-6 production GO:0032755 9.61 IL1B IL6 TSLP
10 interleukin-7-mediated signaling pathway GO:0038111 9.58 IL7 IRS2 TSLP
11 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.56 IL1B IL7
12 positive regulation of JAK-STAT cascade GO:0046427 9.55 IL5 IL6
13 positive regulation of chemokine production GO:0032722 9.54 IL6 IL7 TSLP
14 positive regulation of immunoglobulin secretion GO:0051024 9.52 IL5 IL6
15 regulation of signaling receptor activity GO:0010469 9.5 IL13 IL1B IL5 IL6 IL7 TNFSF13B
16 positive regulation of cytokine-mediated signaling pathway GO:0001961 9.49 IL7 TSLP
17 positive regulation of B cell proliferation GO:0030890 9.02 IL13 IL5 IL7 IRS2 TNFSF13B

Molecular functions related to Ascaris Lumbricoides Infection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 IL5 IL6 IL7
2 cytokine receptor binding GO:0005126 9.26 IL13 IL7
3 cytokine activity GO:0005125 9.17 IL13 IL1B IL5 IL6 IL7 TNFSF13B
4 interleukin-7 receptor binding GO:0005139 8.96 IL7 TSLP

Sources for Ascaris Lumbricoides Infection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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