MCID: ASC010
MIFTS: 52

Ascaris Lumbricoides Infection

Categories: Infectious diseases

Aliases & Classifications for Ascaris Lumbricoides Infection

MalaCards integrated aliases for Ascaris Lumbricoides Infection:

Name: Ascaris Lumbricoides Infection 58 12
Ascariasis 58 12 77 3 45 15 17 74
Ascaris Lumbricoides Infection, Susceptibility to 58
Ascariasis, Susceptibility to 58
Ascariasis - Roundworm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:456
OMIM 58 604291
ICD9CM 36 127.0
MeSH 45 D001196
NCIt 51 C128392
SNOMED-CT 69 2435008
UMLS 74 C0003950

Summaries for Ascaris Lumbricoides Infection

OMIM : 58 More than a quarter of the human population is affected by soil-transmitted helminthes, which impair nutrition and the immune response to widespread pandemics, such as acquired immunodeficiency syndrome (see 609423) and tuberculosis (see 607948). The roundworm Ascaris lumbricoides, the most common human parasite of the gastrointestinal tract, causes ascariasis, which has a worldwide distribution with highest prevalence in tropical and subtropical regions and in areas with inadequate sanitation. Ascariasis is triggered by ingestion of parasite eggs. During its life cycle, Ascaris threatens human health with nonspecific abdominal symptoms, intestinal obstruction and perforation, biliary colic, gallstone formation, liver abscesses, pancreatitis, and pulmonary eosinophilia (Sanglas et al., 2009). (604291)

MalaCards based summary : Ascaris Lumbricoides Infection, also known as ascariasis, is related to enterobiasis and dermatitis. An important gene associated with Ascaris Lumbricoides Infection is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include liver, lung and spleen, and related phenotypes are growth/size/body region and digestive/alimentary

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the intestine with the nematode Ascaris lumbricoides. Larvae migrating through the lungs cause cough, wheezing and hemoptysis. Bowel or biliary obstruction causes cramping abdominal pain, nausea, and vomiting. Peritonitis, enlargement of the liver or spleen, toxicity and pneumonia are observed when larvae get into the portal circulation.

CDC : 3  

Wikipedia : 77 Ascariasis is a disease caused by the parasitic roundworm Ascaris lumbricoides. Infections have no... more...

Related Diseases for Ascaris Lumbricoides Infection

Diseases related to Ascaris Lumbricoides Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 252)
# Related Disease Score Top Affiliating Genes
1 enterobiasis 30.9 IL13 IL5
2 dermatitis 30.6 IL13 IL5 TSLP
3 strongyloidiasis 30.4 IL13 IL5
4 echinococcosis 30.2 IL5 IL6
5 mesenteric lymphadenitis 30.0 IL5 IL6
6 cysticercosis 30.0 IL1B IL6
7 dermatitis, atopic 29.8 CXCL8 IL13 IL5 TSLP
8 necatoriasis 29.8 CXCL8 IL5
9 malaria 29.5 CXCL8 IL13 IL1B IL5 IL6
10 appendicitis 29.4 CXCL8 IL1B IL6
11 wells syndrome 29.3 CXCL8 IL1B IL5
12 peritonitis 29.1 CXCL8 IL1B IL6
13 otitis media 29.1 CXCL8 IL1B IL6
14 chagas disease 29.1 CXCL8 IL1B IL6
15 asthma 29.1 CXCL8 IL13 IL1B IL5 IL6 TSLP
16 trichuriasis 10.5
17 intestinal obstruction 10.4
18 ankylostomiasis 10.4
19 cytokine deficiency 10.3 IL13 IL5
20 respiratory syncytial virus infectious disease 10.3 IL13 IL5
21 nickel allergic contact dermatitis 10.3 IL13 IL5
22 paragonimiasis 10.3 IL13 IL5
23 ancylostomiasis 10.3
24 inflammatory bowel disease 4 10.3 IL13 IL5
25 angiostrongyliasis 10.3 IL13 IL5
26 apple allergy 10.3 IL13 IL5
27 ige responsiveness, atopic 10.3
28 latex allergy 10.3 IL13 IL5
29 eosinophilic meningitis 10.3 IL13 IL5
30 paracoccidioidomycosis 10.3 IL5 IL6
31 intestinal schistosomiasis 10.3 IL13 IL5
32 yellow fever 10.3 IL5 IL6
33 chronic tic disorder 10.3 IL13 IL5
34 eosinophilic gastritis 10.3 IL13 IL5
35 cryoglobulinemia 10.3 TNFSF13B TSLP
36 macroglobulinemia 10.3 IL6 TNFSF13B
37 vernal keratoconjunctivitis 10.3 IL13 IL5
38 urinary schistosomiasis 10.3 IL13 IL5
39 acute pancreatitis 10.3
40 toxocariasis 10.3
41 pollen allergy 10.3 IL13 IL5
42 conjunctival disease 10.2 IL13 IL5
43 eosinophilic gastroenteritis 10.2 IL5 TSLP
44 multicentric castleman disease 10.2 IL5 IL6
45 night blindness, congenital stationary, type 1a 10.2 IL13 IL5
46 kimura disease 10.2 IL5 TSLP
47 pulmonary eosinophilia 10.2 IL13 IL5
48 stevens-johnson syndrome/toxic epidermal necrolysis 10.2 IL13 IL5
49 paranasal sinus disease 10.2 IL13 IL5
50 eosinophilic pneumonia 10.2 IL13 IL5

Graphical network of the top 20 diseases related to Ascaris Lumbricoides Infection:



Diseases related to Ascaris Lumbricoides Infection

Symptoms & Phenotypes for Ascaris Lumbricoides Infection

Clinical features from OMIM:

604291

MGI Mouse Phenotypes related to Ascaris Lumbricoides Infection:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.7 IL13 IL1B IL5 IL6 IRS2 LIG4
2 digestive/alimentary MP:0005381 9.65 IL13 IL5 IL6 LIG4 TSLP
3 hematopoietic system MP:0005397 9.5 IL13 IL1B IL5 IL6 LIG4 TNFSF13B
4 immune system MP:0005387 9.23 IL13 IL1B IL5 IL6 IRS2 LIG4

Drugs & Therapeutics for Ascaris Lumbricoides Infection

Search Clinical Trials , NIH Clinical Center for Ascaris Lumbricoides Infection

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: ascariasis

Genetic Tests for Ascaris Lumbricoides Infection

Anatomical Context for Ascaris Lumbricoides Infection

MalaCards organs/tissues related to Ascaris Lumbricoides Infection:

42
Liver, Lung, Spleen, Testes, Skin, Kidney, Eye

Publications for Ascaris Lumbricoides Infection

Articles related to Ascaris Lumbricoides Infection:

(show top 50) (show all 857)
# Title Authors Year
1
Biliary Ascariasis Mimicking as Choledocholithiasis on Endoscopic Ultrasound. ( 30935184 )
2019
2
Biliary Ascariasis: An Unusual Case of Obstructive Jaundice. ( 30710698 )
2019
3
Efficacy of Albendazole and Mebendazole With or Without Levamisole for Ascariasis and Trichuriasis. ( 31110573 )
2019
4
Incidental diagnosis of appendiceal ascariasis during colonoscopy. ( 30115571 )
2019
5
Ascariasis as a model to study the helminth/allergy relationships. ( 30295330 )
2019
6
The inner tube sign in Ascariasis. ( 30498923 )
2019
7
Ascariasis and its relationship with selected psycho-neurological symptoms among children and adults in Poland. ( 31099762 )
2019
8
Recurrent acute pancreatitis due to pancreatic duct ascariasis in a young man. ( 30096718 )
2018
9
A case of atopic dermatitis caused by Ascaris lumbricoides infection. ( 29651227 )
2018
10
Ascaris lumbricoides infection induces both, reduction and increase of asthma symptoms in a rural community. ( 30040946 )
2018
11
Successful Elimination of Gallbladder Ascariasis by Conservative Therapy, Followed by Cholecystectomy due to Developing Cholecystitis. ( 30643654 )
2018
12
Small bowel volvulus in an adult with mesenteric lymphangioma and ascariasis. ( 28266164 )
2018
13
Concomitant ascariasis as a factor in reducing the quality of life of patients with chronic pancreatitis. ( 30448792 )
2018
14
Ascariasis Diagnosed by Wireless Capsule Endoscopy. ( 28865763 )
2018
15
Ascariasis seen by videocapsule endoscopy. ( 29222943 )
2018
16
Gallbladder ascariasis in Kosovo - focus on ultrasound and conservative therapy: a case series. ( 29329599 )
2018
17
A Worm Hole: Liver Abscess in Ascariasis. ( 29518367 )
2018
18
EUS of pancreatic ascariasis. ( 29523472 )
2018
19
Biliary ascariasis presenting with gangrenous perforation of the gall bladder: report of a case and brief review of literature. ( 29649951 )
2018
20
Gastrointestinal: An unusual cause of biliary colic: Biliary ascariasis. ( 29659086 )
2018
21
High prevalence of ascariasis on two coral atolls in the Solomon Islands. ( 29800343 )
2018
22
Differential diagnosis of gallbladder ascariasis debris: the added value of contrast enhanced ultrasound with high frequency transducer. ( 30534646 )
2018
23
Sources of variability in the measurement of Ascaris lumbricoides infection intensity by Kato-Katz and qPCR. ( 28545561 )
2017
24
Ascariasis and pancreatitis. ( 28937027 )
2017
25
Ascaris lumbricoides through pleural biopsy needle. A rare case of intrapleural ascariasis. ( 27823891 )
2017
26
Intestinal ascariasis detected by double-balloon enteroscopy. ( 28066936 )
2017
27
Ascariasis and hyperosmolar hyperglycemic state: a surprising ultrasound finding in the emergency department. ( 28324468 )
2017
28
Combination of laparoscope and choledochoscope to treat biliary ascariasis: A CARE-compliant case report. ( 28353561 )
2017
29
Post Extubation Bronchospasm in an Undiagnosed Case of Ascariasis: Anaesthetic Challenges. ( 28384964 )
2017
30
Ascariasis imaging: pictorial essay. ( 28499324 )
2017
31
Hematuria from urinary ascariasis. ( 28501309 )
2017
32
Endoscopic ultrasound of bile duct ascariasis (with video). ( 28621300 )
2017
33
Hygienic Behaviors and Risks for Ascariasis among College Students in Kabul, Afghanistan. ( 28829737 )
2017
34
You Traveled the World and All You Got Was Ascariasis. ( 29056213 )
2017
35
A multilevel study of the environmental determinants of swine ascariasis in England. ( 29157367 )
2017
36
A Case of Biliary Ascariasis in Korea. ( 29320821 )
2017
37
Biliary ascariasis: mimicker of biliary stent. ( 29905283 )
2017
38
Acute pancreatitis due to ascariasis: a sonographic pictorial essay on four cases. ( 27059341 )
2016
39
Ascaris lumbricoides Infection Following School-Based Deworming in Western Kenya: Assessing the Role of Pupils' School and Home Water, Sanitation, and Hygiene Exposures. ( 26903608 )
2016
40
Effect of Ascaris lumbricoides infection on T helper cell type 2 in rural Egyptian children. ( 27022269 )
2016
41
FACTORS ASSOCIATED WITH THE PREVALENCE OF ASCARIS LUMBRICOIDES INFECTION AMONG PRESCHOOL CHILDREN IN A PLANTATION COMMUNITY, KANDY DISTRICT, SRI LANKA. ( 29634161 )
2016
42
A rare cause of dysphagia: pharyngeal ascariasis. ( 27876959 )
2016
43
OVERDIAGNOSIS OF COELIAC DISEASE IN A PATIENT WITH ASCARIASIS AND GIARDIASIS. ( 29889407 )
2016
44
Respiratory Failure Associated with Ascariasis in a Patient with Immunodeficiency. ( 27313919 )
2016
45
Pancreatic duct ascariasis. ( 26348548 )
2016
46
Hepatobiliary and pancreatic ascariasis-sonographic pictorial essay on four pediatric cases with acute biliary colic. ( 26690772 )
2016
47
Endoscopic ultrasound of pancreatic duct ascariasis. ( 26822523 )
2016
48
Endoscopic ultrasound imaging of pancreatic duct ascariasis. ( 26829193 )
2016
49
Intrahepatic Duct Stones Harboring Ascariasis Ova: A Case Report. ( 27015193 )
2016
50
A Co-Presentation of Biliary Ascariasis and Hepatic Hydatidosis. ( 27042559 )
2016

Variations for Ascaris Lumbricoides Infection

Expression for Ascaris Lumbricoides Infection

Search GEO for disease gene expression data for Ascaris Lumbricoides Infection.

Pathways for Ascaris Lumbricoides Infection

Pathways related to Ascaris Lumbricoides Infection according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 CXCL8 IL13 IL1B IL5 IL6 IRS2
2
Show member pathways
13.69 CXCL8 IL13 IL1B IL5 IL6 IRS2
3
Show member pathways
13.5 CXCL8 IL13 IL1B IL5 IL6 TNFSF13B
4
Show member pathways
13.36 CXCL8 IL13 IL1B IL5 IL6 IRS2
5
Show member pathways
13.26 CXCL8 IL13 IL1B IL5 IL6 TNFSF13B
6
Show member pathways
13.18 CXCL8 IL13 IL1B IL5 IL6 IRS2
7
Show member pathways
13.15 CXCL8 IL13 IL1B IL5 IL6 TNFSF13B
8 12.71 CXCL8 IL13 IL5 IL6
9
Show member pathways
12.71 CXCL8 IL13 IL1B IL5 IL6 TNFSF13B
10
Show member pathways
12.49 IL13 IL1B IL5 IL6
11
Show member pathways
12.43 IL1B IL5 IL6
12
Show member pathways
12.31 IL13 IL1B IL5
13
Show member pathways
12.3 IL13 IL5 IL6 TSLP
14
Show member pathways
12.18 CXCL8 IL1B IL6
15
Show member pathways
12.16 CXCL8 IL13 IL1B IL5 IL6
16
Show member pathways
12.13 CXCL8 IL13 IL1B IL5 IL6
17
Show member pathways
12.11 CXCL8 IL1B IL6
18
Show member pathways
12.08 CXCL8 IL1B IL6
19 12.08 CXCL8 IL13 IL1B IL6
20
Show member pathways
11.96 IL13 IL1B IL6
21
Show member pathways
11.95 IL13 IL1B IL5
22 11.94 CXCL8 IL1B IL6 TNFSF13B
23 11.89 CXCL8 IL13 IL1B IL6
24 11.87 CXCL8 IL1B IL6
25 11.84 CXCL8 IL1B IL6
26 11.83 IL1B IL5 IL6
27 11.83 CXCL8 IL1B TNFSF13B
28 11.82 CXCL8 IL1B IL6
29
Show member pathways
11.81 CXCL8 IL13 IL1B IL5 IL6 TNFSF13B
30 11.77 CXCL8 IL1B IL6 TNFSF13B
31 11.76 CXCL8 IL1B IL6
32 11.7 CXCL8 IL1B IL6
33 11.69 CXCL8 IL13 IL5 IL6
34 11.66 IL13 IL1B IL6
35 11.66 IL13 IL1B IL5 TSLP
36
Show member pathways
11.6 CXCL8 IL1B IL6
37 11.53 CXCL8 IL1B IL6
38 11.46 CXCL8 IL1B IL6
39 11.45 IL1B IL5 IL6
40 11.43 CXCL8 IL6 TSLP
41 11.36 CXCL8 IL13 IL1B IL6
42 11.28 IL1B IL6
43 11.25 IL1B IL6
44 11.25 IL1B IL6
45 11.23 CXCL8 IL6
46 11.19 IL1B IL6
47 11.15 CXCL8 IL13 IL1B IL5 IL6
48 11.11 IL13 IL5
49 11.04 IL6 IRS2
50 11.02 IL13 IL1B IL5 IL6

GO Terms for Ascaris Lumbricoides Infection

Cellular components related to Ascaris Lumbricoides Infection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CXCL8 IL13 IL1B IL5 IL6 TNFSF13B
2 extracellular space GO:0005615 9.17 CXCL8 IL13 IL1B IL5 IL6 TNFSF13B

Biological processes related to Ascaris Lumbricoides Infection according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.77 IL1B IL5 IRS2
2 inflammatory response GO:0006954 9.77 CXCL8 IL13 IL1B IL5 IL6
3 positive regulation of cell proliferation GO:0008284 9.73 IL1B IL5 IL6 IRS2 TNFSF13B TSLP
4 cellular response to lipopolysaccharide GO:0071222 9.72 CXCL8 IL1B IL6
5 cytokine-mediated signaling pathway GO:0019221 9.72 CXCL8 IL13 IL1B IL5 IL6
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.67 IL1B IL5 IL6
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.63 IL13 IL6 TSLP
8 immune response GO:0006955 9.63 CXCL8 IL13 IL1B IL5 IL6 TNFSF13B
9 positive regulation of T cell proliferation GO:0042102 9.61 IL1B IL6 TNFSF13B
10 interleukin-7-mediated signaling pathway GO:0038111 9.59 IRS2 TSLP
11 positive regulation of JAK-STAT cascade GO:0046427 9.58 IL5 IL6
12 positive regulation of interleukin-6 production GO:0032755 9.58 IL1B IL6 TSLP
13 negative regulation of neurogenesis GO:0050768 9.57 IL1B IL6
14 positive regulation of chemokine production GO:0032722 9.54 IL6 TSLP
15 positive regulation of glial cell proliferation GO:0060252 9.52 IL1B IL6
16 positive regulation of immunoglobulin secretion GO:0051024 9.51 IL5 IL6
17 positive regulation of neuroinflammatory response GO:0150078 9.48 IL1B IL6
18 response to gamma radiation GO:0010332 9.28 LIG4
19 positive regulation of neutrophil chemotaxis GO:0090023 9.26 CXCL8
20 positive regulation of B cell proliferation GO:0030890 9.26 IL13 IL5 IRS2 TNFSF13B
21 regulation of signaling receptor activity GO:0010469 9.17 CXCL8 IL13 IL1B IL5 IL6 TNFSF13B

Molecular functions related to Ascaris Lumbricoides Infection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CXCL8 IL13 IL1B IL5 IL6 TNFSF13B

Sources for Ascaris Lumbricoides Infection

3 CDC
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10 dbSNP
11 DGIdb
17 EFO
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20 FMA
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31 HGMD
32 HMDB
33 HPO
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35 ICD10 via Orphanet
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37 IUPHAR
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45 MeSH
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47 MGI
50 NCI
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63 PubMed
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70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
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75 UMLS via Orphanet
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