MCID: ASC010
MIFTS: 50

Ascaris Lumbricoides Infection

Categories: Infectious diseases

Aliases & Classifications for Ascaris Lumbricoides Infection

MalaCards integrated aliases for Ascaris Lumbricoides Infection:

Name: Ascaris Lumbricoides Infection 58 12
Ascariasis 58 12 77 45 15 17 74 3
Ascaris Lumbricoides Infection, Susceptibility to 58
Ascariasis, Susceptibility to 58
Ascariasis - Roundworm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:456
OMIM 58 604291
ICD9CM 36 127.0
MeSH 45 D001196
NCIt 51 C128392
SNOMED-CT 69 2435008
UMLS 74 C0003950

Summaries for Ascaris Lumbricoides Infection

OMIM : 58 More than a quarter of the human population is affected by soil-transmitted helminthes, which impair nutrition and the immune response to widespread pandemics, such as acquired immunodeficiency syndrome (see 609423) and tuberculosis (see 607948). The roundworm Ascaris lumbricoides, the most common human parasite of the gastrointestinal tract, causes ascariasis, which has a worldwide distribution with highest prevalence in tropical and subtropical regions and in areas with inadequate sanitation. Ascariasis is triggered by ingestion of parasite eggs. During its life cycle, Ascaris threatens human health with nonspecific abdominal symptoms, intestinal obstruction and perforation, biliary colic, gallstone formation, liver abscesses, pancreatitis, and pulmonary eosinophilia (Sanglas et al., 2009). (604291)

MalaCards based summary : Ascaris Lumbricoides Infection, also known as ascariasis, is related to enterobiasis and dermatitis. An important gene associated with Ascaris Lumbricoides Infection is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include liver, lung and spleen, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the intestine with the nematode Ascaris lumbricoides. Larvae migrating through the lungs cause cough, wheezing and hemoptysis. Bowel or biliary obstruction causes cramping abdominal pain, nausea, and vomiting. Peritonitis, enlargement of the liver or spleen, toxicity and pneumonia are observed when larvae get into the portal circulation.

CDC : 3 An estimated 807 million–1.2 billion people in the world are infected with Ascaris lumbricoides (sometimes called just Ascaris or ascariasis). Ascaris, hookworm, and whipworm are parasitic worms known as soil-transmitted helminths (STH). Together, they account for a major burden of parasitic disease worldwide. Ascariasis is now uncommon in the United States.

Wikipedia : 77 Ascariasis is a disease caused by the parasitic roundworm Ascaris lumbricoides. Infections have no... more...

Related Diseases for Ascaris Lumbricoides Infection

Diseases related to Ascaris Lumbricoides Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 241)
# Related Disease Score Top Affiliating Genes
1 enterobiasis 30.8 IL13 IL5
2 dermatitis 30.3 IFNG IL13 IL5
3 ige responsiveness, atopic 30.3 IFNG IL13 IL5
4 schistosomiasis 30.1 IFNG IL13 IL5
5 necatoriasis 30.1 CXCL8 IL5
6 strongyloidiasis 30.0 IFNG IL13 IL5
7 pleurisy 30.0 CXCL8 IFNG
8 wells syndrome 29.9 CXCL8 IL5
9 dermatitis, atopic 29.8 CXCL8 IFNG IL13 IL5
10 mesenteric lymphadenitis 29.8 IL5 IL6
11 malaria 29.6 CXCL8 IFNG IL13 IL5 IL6
12 asthma 29.6 CXCL8 IFNG IL13 IL5 IL6
13 chagas disease 29.2 CXCL8 IFNG IL6
14 ascaridiasis 11.7
15 trichuriasis 10.5
16 intestinal obstruction 10.4
17 cytokine deficiency 10.3 IL13 IL5
18 respiratory syncytial virus infectious disease 10.3 IL13 IL5
19 paragonimiasis 10.3 IL13 IL5
20 ancylostomiasis 10.3
21 inflammatory bowel disease 4 10.3 IL13 IL5
22 angiostrongyliasis 10.3 IL13 IL5
23 apple allergy 10.3 IL13 IL5
24 esophagitis, eosinophilic, 1 10.3 IL13 IL5
25 latex allergy 10.3 IL13 IL5
26 eosinophilic meningitis 10.3 IL13 IL5
27 intestinal schistosomiasis 10.3 IL13 IL5
28 chronic tic disorder 10.3 IL13 IL5
29 chronic conjunctivitis 10.3 IL13 IL5
30 eosinophilic gastritis 10.3 IL13 IL5
31 vernal keratoconjunctivitis 10.3 IL13 IL5
32 acute pancreatitis 10.3
33 toxocariasis 10.3
34 eosinophilic fasciitis 10.3 IFNG IL5
35 cephalosporin allergy 10.3 IFNG IL5
36 pollen allergy 10.3 IL13 IL5
37 scleritis 10.3 IFNG IL5
38 atopic keratoconjunctivitis 10.2 IFNG IL5
39 eosinophilia-myalgia syndrome 10.2 IFNG IL5
40 conjunctival disease 10.2 IL13 IL5
41 chronic graft versus host disease 10.2 IFNG TNFSF13B
42 status asthmaticus 10.2 CXCL8 IL5
43 toxic oil syndrome 10.2 IFNG IL5
44 night blindness, congenital stationary, type 1a 10.2 IL13 IL5
45 folliculitis 10.2 IFNG IL5
46 sinusitis 10.2 CXCL8 IL5
47 african tick-bite fever 10.2 IFNG IL13
48 penicillin allergy 10.2 IFNG IL13
49 pulmonary eosinophilia 10.2 IL13 IL5
50 eosinophilic pneumonia 10.2 IL13 IL5

Graphical network of the top 20 diseases related to Ascaris Lumbricoides Infection:



Diseases related to Ascaris Lumbricoides Infection

Symptoms & Phenotypes for Ascaris Lumbricoides Infection

Clinical features from OMIM:

604291

MGI Mouse Phenotypes related to Ascaris Lumbricoides Infection:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.8 IFNG IL13 IL6 IL7 IRS2 LIG4
2 hematopoietic system MP:0005397 9.8 IFNG IL13 IL5 IL6 IL7 LIG4
3 digestive/alimentary MP:0005381 9.77 IFNG IL13 IL5 IL6 LIG4
4 immune system MP:0005387 9.76 IFNG IL13 IL5 IL6 IL7 IRS2
5 liver/biliary system MP:0005370 9.35 IFNG IL5 IL6 IRS2 LIG4
6 reproductive system MP:0005389 9.1 IFNG IL13 IL5 IL6 IRS2 LIG4

Drugs & Therapeutics for Ascaris Lumbricoides Infection

Search Clinical Trials , NIH Clinical Center for Ascaris Lumbricoides Infection

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: ascariasis

Genetic Tests for Ascaris Lumbricoides Infection

Anatomical Context for Ascaris Lumbricoides Infection

MalaCards organs/tissues related to Ascaris Lumbricoides Infection:

42
Liver, Lung, Spleen, Skin, Brain, Testes, Small Intestine

Publications for Ascaris Lumbricoides Infection

Articles related to Ascaris Lumbricoides Infection:

(show top 50) (show all 287)
# Title Authors Year
1
Biliary ascariasis - an unusual case of obstructive jaundice. ( 30710698 )
2019
2
Recurrent acute pancreatitis due to pancreatic duct ascariasis in a young man. ( 30096718 )
2018
3
Ascaris lumbricoides infection induces both, reduction and increase of asthma symptoms in a rural community. ( 30040946 )
2018
4
Successful Elimination of Gallbladder Ascariasis by Conservative Therapy, Followed by Cholecystectomy due to Developing Cholecystitis. ( 30643654 )
2018
5
Concomitant ascariasis as a factor in reducing the quality of life of patients with chronic pancreatitis. ( 30448792 )
2018
6
Ascariasis seen by videocapsule endoscopy. ( 29222943 )
2018
7
Gallbladder ascariasis in Kosovo - focus on ultrasound and conservative therapy: a case series. ( 29329599 )
2018
8
A Worm Hole: Liver Abscess in Ascariasis. ( 29518367 )
2018
9
EUS of pancreatic ascariasis. ( 29523472 )
2018
10
Biliary ascariasis presenting with gangrenous perforation of the gall bladder: report of a case and brief review of literature. ( 29649951 )
2018
11
Gastrointestinal: An unusual cause of biliary colic: Biliary ascariasis. ( 29659086 )
2018
12
High prevalence of ascariasis on two coral atolls in the Solomon Islands. ( 29800343 )
2018
13
Incidental diagnosis of appendiceal ascariasis during colonoscopy. ( 30115571 )
2018
14
Ascariasis as a model to study the helminth/allergy relationships. ( 30295330 )
2018
15
The inner tube sign in Ascariasis. ( 30498923 )
2018
16
Differential diagnosis of gallbladder ascariasis debris: the added value of contrast enhanced ultrasound with high frequency transducer. ( 30534646 )
2018
17
Sources of variability in the measurement of Ascaris lumbricoides infection intensity by Kato-Katz and qPCR. ( 28545561 )
2017
18
You Traveled the World and All You Got Was Ascariasis. ( 29056213 )
2017
19
A multilevel study of the environmental determinants of swine ascariasis in England. ( 29157367 )
2017
20
A Case of Biliary Ascariasis in Korea. ( 29320821 )
2017
21
Biliary ascariasis: mimicker of biliary stent. ( 29905283 )
2017
22
Effect of Ascaris lumbricoides infection on T helper cell type 2 in rural Egyptian children. ( 27022269 )
2016
23
Ascaris lumbricoides Infection Following School-Based Deworming in Western Kenya: Assessing the Role of Pupils' School and Home Water, Sanitation, and Hygiene Exposures. ( 26903608 )
2016
24
FACTORS ASSOCIATED WITH THE PREVALENCE OF ASCARIS LUMBRICOIDES INFECTION AMONG PRESCHOOL CHILDREN IN A PLANTATION COMMUNITY, KANDY DISTRICT, SRI LANKA. ( 29634161 )
2016
25
OVERDIAGNOSIS OF COELIAC DISEASE IN A PATIENT WITH ASCARIASIS AND GIARDIASIS. ( 29889407 )
2016
26
A Cross-Sectional Study of Ascaris lumbricoides Infection in a Rural Community in Ebonyi State, Nigeria: Prevalence and Risk Factors. ( 26576362 )
2015
27
Ascaris lumbricoides infection in urban schoolchildren: specific IgE and IL-10 production. ( 23648101 )
2014
28
Detecting and Accommodating Outliers in Meta-Analysis for Evaluating Effect of Albendazole on Ascaris lumbricoides Infection. ( 25031857 )
2014
29
Ascaris lumbricoides infection and parasite load are associated with asthma in children. ( 25022300 )
2014
30
Ascaris lumbricoides infection and its relation to environmental factors in the Mbeya region of Tanzania, a cross-sectional, population-based study. ( 24643023 )
2014
31
Diagnosis of Ascaris lumbricoides infection using capsule endoscopy. ( 23596544 )
2013
32
Coincident diagnosis of a pulmonary abscess and ascaris lumbricoides infection: a possible causal connection? ( 22821292 )
2012
33
Severity of atopic dermatitis and Ascaris lumbricoides infection: an evaluation of CCR4+ and CXCR3+ helper T cell frequency. ( 23295884 )
2012
34
Differential changes in expression of intestinal antimicrobial peptide genes during Ascaris lumbricoides infection in Zambian adults do not respond to helminth eradication. ( 21357944 )
2011
35
Analysis of clinical symptoms and selected hematological indices in hospitalized children with Ascaris lumbricoides infection from the northeastern region of Poland. ( 21634234 )
2011
36
Ascaris lumbricoides infection causing respiratory distress after coronary artery bypass grafting. ( 19803729 )
2010
37
Ascaris lumbricoides infection: an unexpected cause of pancreatitis in a western Mediterranean country. ( 20795455 )
2010
38
Association between total immunoglobulin E and antibody responses to naturally acquired Ascaris lumbricoides infection and polymorphisms of immune system-related LIG4, TNFSF13B and IRS2 genes. ( 19604268 )
2009
39
Antibody responses and resistance against Ascaris lumbricoides infection among Venezuelan rural children: the influence of ethnicity. ( 18453627 )
2008
40
Intermittent obstruction of jejunostomy tube due to Ascaris lumbricoides infection. ( 18475230 )
2008
41
Hookworm, Ascaris lumbricoides infection and polyparasitism associated with poor cognitive performance in Brazilian schoolchildren. ( 18627581 )
2008
42
Prevalence of biliary ascariasis and its relation to biliary lithiasis. ( 27277620 )
2006
43
Comment on: Severe malaria attack is associated with high prevalence of Ascaris lumbricoides infection among children in rural Senegal. ( 15607342 )
2005
44
Ecological covariates of Ascaris lumbricoides infection in schoolchildren from rural KwaZulu-Natal, South Africa. ( 15860087 )
2005
45
Immuno-epidemiology of Ascaris lumbricoides infection in a high transmission community: antibody responses and their impact on current and future infection intensity. ( 15882235 )
2005
46
Acute interstitial nephritis in a case of Ascaris lumbricoides infection. ( 15150358 )
2004
47
Severe malaria attack is associated with high prevalence of Ascaris lumbricoides infection among children in rural Senegal. ( 15138075 )
2004
48
The risk of Ascaris lumbricoides infection in children as an environmental health indicator to guide preventive activities in Caparaó and Alto Caparaó, Brazil. ( 11884972 )
2002
49
Ascaris lumbricoides infection is associated with increased risk of childhood asthma and atopy in rural China. ( 12045121 )
2002
50
Ascaris lumbricoides infection is associated with protection from cerebral malaria. ( 10672191 )
2000

Variations for Ascaris Lumbricoides Infection

Expression for Ascaris Lumbricoides Infection

Search GEO for disease gene expression data for Ascaris Lumbricoides Infection.

Pathways for Ascaris Lumbricoides Infection

Pathways related to Ascaris Lumbricoides Infection according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 CXCL8 IFNG IL13 IL5 IL6 IL7
2
Show member pathways
13.69 CXCL8 IL13 IL5 IL6 IL7 IRS2
3
Show member pathways
13.51 CXCL8 IFNG IL13 IL5 IL6 IL7
4
Show member pathways
13.26 CXCL8 IL13 IL5 IL6 IL7 TNFSF13B
5
Show member pathways
13.24 CXCL8 IFNG IL13 IL5 IL6 IL7
6
Show member pathways
13.15 CXCL8 IL13 IL5 IL6 IL7 TNFSF13B
7
Show member pathways
13.08 CXCL8 IFNG IL13 IL5 IL6 IL7
8
Show member pathways
12.74 CXCL8 IFNG IL13 IL5 IL6 TNFSF13B
9 12.68 CXCL8 IFNG IL13 IL5 IL6 IL7
10
Show member pathways
12.49 IFNG IL13 IL5 IL6
11
Show member pathways
12.46 CXCL8 IFNG IL13 IL6
12
Show member pathways
12.31 IFNG IL13 IL5 IL6 IL7
13
Show member pathways
12.29 IFNG IL5 IL6
14
Show member pathways
12.19 CXCL8 IFNG IL13 IL5 IL6
15
Show member pathways
12.18 CXCL8 IFNG IL6
16
Show member pathways
12.18 IFNG IL6 IRS2
17
Show member pathways
12.17 CXCL8 IFNG IL13 IL5 IL6
18
Show member pathways
12.08 CXCL8 IFNG IL6
19 12.07 CXCL8 IL13 IL6
20 11.96 CXCL8 IFNG IL6 TNFSF13B
21
Show member pathways
11.95 IFNG IL13 IL6
22 11.93 IFNG IL5 IL6 IL7
23 11.9 CXCL8 IL13 IL6
24 11.87 CXCL8 IFNG IL6
25 11.83 IL5 IL6 IL7
26 11.82 CXCL8 IFNG IL6
27 11.8 CXCL8 IFNG IL6 TNFSF13B
28 11.76 CXCL8 IFNG IL6
29 11.71 IFNG IL13 IL5 IL7
30
Show member pathways
11.71 CXCL8 IFNG IL13 IL5 IL6 IL7
31
Show member pathways
11.7 CXCL8 IFNG IL5
32 11.66 IFNG IL13 IL6
33 11.63 CXCL8 IFNG IL13 IL5 IL6
34
Show member pathways
11.6 CXCL8 IFNG IL6
35 11.53 CXCL8 IFNG IL6
36 11.53 CXCL8 IL13 IL5 IL6
37 11.47 CXCL8 IL13 IL6
38 11.46 CXCL8 IFNG IL6
39 11.43 IFNG IL13 IL5
40 11.36 IFNG IL6
41 11.35 CXCL8 IFNG
42 11.27 IFNG IL6
43 11.23 CXCL8 IL6
44 11.22 IFNG IL5
45 11.17 IFNG IL13 IL5
46 11.14 IFNG IL13
47 11.03 IL6 IRS2
48 10.96 CXCL8 IL6
49 10.96 CXCL8 IL13 IL5 IL6 IL7 TNFSF13B
50 10.87 CXCL8 IL13 IL5 IL6 IL7 TNFSF13B

GO Terms for Ascaris Lumbricoides Infection

Cellular components related to Ascaris Lumbricoides Infection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CXCL8 IFNG IL13 IL5 IL6 IL7
2 extracellular space GO:0005615 9.17 CXCL8 IFNG IL13 IL5 IL6 IL7

Biological processes related to Ascaris Lumbricoides Infection according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.73 CXCL8 IL13 IL5 IL6
2 positive regulation of cell proliferation GO:0008284 9.73 IFNG IL5 IL6 IL7 IRS2 TNFSF13B
3 cytokine-mediated signaling pathway GO:0019221 9.72 CXCL8 IL13 IL5 IL6 IL7
4 immune response GO:0006955 9.7 CXCL8 IFNG IL13 IL5 IL6 IL7
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 IFNG IL13 IL6
6 humoral immune response GO:0006959 9.54 IFNG IL6 IL7
7 interleukin-7-mediated signaling pathway GO:0038111 9.51 IL7 IRS2
8 regulation of signaling receptor activity GO:0010469 9.5 CXCL8 IFNG IL13 IL5 IL6 IL7
9 positive regulation of JAK-STAT cascade GO:0046427 9.49 IL5 IL6
10 positive regulation of chemokine production GO:0032722 9.48 IL6 IL7
11 positive regulation of immunoglobulin secretion GO:0051024 9.46 IL5 IL6
12 positive regulation of B cell proliferation GO:0030890 9.02 IL13 IL5 IL7 IRS2 TNFSF13B

Molecular functions related to Ascaris Lumbricoides Infection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CXCL8 IFNG IL13 IL5 IL6 IL7
2 cytokine receptor binding GO:0005126 9.16 IL13 IL7
3 growth factor activity GO:0008083 9.13 IL5 IL6 IL7

Sources for Ascaris Lumbricoides Infection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
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43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
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75 UMLS via Orphanet
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