MCID: ASC010
MIFTS: 52

Ascaris Lumbricoides Infection

Categories: Infectious diseases

Aliases & Classifications for Ascaris Lumbricoides Infection

MalaCards integrated aliases for Ascaris Lumbricoides Infection:

Name: Ascaris Lumbricoides Infection 57 12
Ascariasis 57 12 76 3 44 15 73
Ascaris Lumbricoides Infection, Susceptibility to 57
Ascariasis, Susceptibility to 57
Ascariasis - Roundworm 12

Classifications:



External Ids:

OMIM 57 604291
Disease Ontology 12 DOID:456
ICD9CM 35 127.0
MeSH 44 D001196
NCIt 50 C128392
SNOMED-CT 68 2435008
UMLS 73 C0003950

Summaries for Ascaris Lumbricoides Infection

OMIM : 57 More than a quarter of the human population is affected by soil-transmitted helminthes, which impair nutrition and the immune response to widespread pandemics, such as acquired immunodeficiency syndrome (see 609423) and tuberculosis (see 607948). The roundworm Ascaris lumbricoides, the most common human parasite of the gastrointestinal tract, causes ascariasis, which has a worldwide distribution with highest prevalence in tropical and subtropical regions and in areas with inadequate sanitation. Ascariasis is triggered by ingestion of parasite eggs. During its life cycle, Ascaris threatens human health with nonspecific abdominal symptoms, intestinal obstruction and perforation, biliary colic, gallstone formation, liver abscesses, pancreatitis, and pulmonary eosinophilia (Sanglas et al., 2009). (604291)

MalaCards based summary : Ascaris Lumbricoides Infection, also known as ascariasis, is related to trichuriasis and enterobiasis. An important gene associated with Ascaris Lumbricoides Infection is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include liver, lung and spleen, and related phenotypes are growth/size/body region and digestive/alimentary

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the intestine with the nematode Ascaris lumbricoides. Larvae migrating through the lungs cause cough, wheezing and hemoptysis. Bowel or biliary obstruction causes cramping abdominal pain, nausea, and vomiting. Peritonitis, enlargement of the liver or spleen, toxicity and pneumonia are observed when larvae get into the portal circulation.

CDC : 3 An estimated 807 million–1.2 billion people in the world are infected with Ascaris lumbricoides (sometimes called just Ascaris or ascariasis). Ascaris, hookworm, and whipworm are parasitic worms known as soil-transmitted helminths (STH). Together, they account for a major burden of parasitic disease worldwide. Ascariasis is now uncommon in the United States.

Wikipedia : 76 Ascariasis is a disease caused by the parasitic roundworm Ascaris lumbricoides. Infections have no... more...

Related Diseases for Ascaris Lumbricoides Infection

Diseases related to Ascaris Lumbricoides Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
# Related Disease Score Top Affiliating Genes
1 trichuriasis 30.7 CXCL8 IL13
2 enterobiasis 30.6 IL13 IL5
3 schistosomiasis 30.1 IFNG IL13 IL5
4 malaria 30.0 CXCL8 IFNG IL13 IL1B IL5
5 strongyloidiasis 29.9 IFNG IL13 IL5
6 dermatitis 29.9 IFNG IL13 IL5 TSLP
7 fascioliasis 29.8 IFNG IL1B
8 necatoriasis 29.7 CXCL8 IL5
9 asthma 29.6 CXCL8 IFNG IL13 IL1B IL5 TSLP
10 peptic ulcer disease 29.6 CXCL8 IL1B
11 wells syndrome 29.5 CXCL8 IL1B IL5
12 dermatitis, atopic 29.5 CXCL8 IFNG IL13 IL5 TSLP
13 pleurisy 29.5 CXCL8 IFNG
14 chagas disease 29.3 CXCL8 IFNG IL1B
15 ascaridiasis 11.6
16 intestinal obstruction 10.3
17 ancylostomiasis 10.3
18 acute pancreatitis 10.2
19 toxocariasis 10.2
20 cytokine deficiency 10.2 IL13 IL5
21 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL13 IL5
22 respiratory syncytial virus infectious disease 10.2 IL13 IL5
23 paragonimiasis 10.2 IL13 IL5
24 angiostrongyliasis 10.2 IL13 IL5
25 inflammatory bowel disease 4 10.2 IL13 IL5
26 apple allergy 10.2 IL13 IL5
27 latex allergy 10.2 IL13 IL5
28 eosinophilic meningitis 10.2 IL13 IL5
29 intestinal schistosomiasis 10.2 IL13 IL5
30 chronic tic disorder 10.2 IL13 IL5
31 eosinophilic gastritis 10.2 IL13 IL5
32 vernal keratoconjunctivitis 10.2 IL13 IL5
33 eosinophilic fasciitis 10.2 IFNG IL5
34 cephalosporin allergy 10.2 IFNG IL5
35 pollen allergy 10.2 IL13 IL5
36 scleritis 10.2 IFNG IL5
37 conjunctival disease 10.2 IL13 IL5
38 atopic keratoconjunctivitis 10.2 IFNG IL5
39 eosinophilia-myalgia syndrome 10.2 IFNG IL5
40 night blindness, congenital stationary, type 1a 10.2 IL13 IL5
41 cercarial dermatitis 10.2 IL1B IL5
42 pulmonary eosinophilia 10.2 IL13 IL5
43 eosinophilic pneumonia 10.1 IL13 IL5
44 interstitial nephritis 10.1
45 cholera 10.1
46 pancreatitis 10.1
47 night blindness 10.1
48 toxic oil syndrome 10.1 IFNG IL5
49 chronic graft versus host disease 10.1 IFNG TNFSF13B
50 folliculitis 10.1 IFNG IL5

Graphical network of the top 20 diseases related to Ascaris Lumbricoides Infection:



Diseases related to Ascaris Lumbricoides Infection

Symptoms & Phenotypes for Ascaris Lumbricoides Infection

Clinical features from OMIM:

604291

MGI Mouse Phenotypes related to Ascaris Lumbricoides Infection:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.7 IFNG IL13 IL1B IL5 IRS2 LIG4
2 digestive/alimentary MP:0005381 9.65 IFNG IL13 IL5 LIG4 TSLP
3 hematopoietic system MP:0005397 9.5 IFNG IL13 IL1B IL5 LIG4 TNFSF13B
4 immune system MP:0005387 9.23 IFNG IL13 IL1B IL5 IRS2 LIG4

Drugs & Therapeutics for Ascaris Lumbricoides Infection

Search Clinical Trials , NIH Clinical Center for Ascaris Lumbricoides Infection

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: ascariasis

Genetic Tests for Ascaris Lumbricoides Infection

Anatomical Context for Ascaris Lumbricoides Infection

MalaCards organs/tissues related to Ascaris Lumbricoides Infection:

41
Liver, Lung, Spleen, Skin, T Cells, Bone, Prostate

Publications for Ascaris Lumbricoides Infection

Articles related to Ascaris Lumbricoides Infection:

(show top 50) (show all 322)
# Title Authors Year
1
Recurrent acute pancreatitis due to pancreatic duct ascariasis in a young man. ( 30096718 )
2018
2
Ascaris lumbricoides infection induces both, reduction and increase of asthma symptoms in a rural community. ( 30040946 )
2018
3
Concomitant ascariasis as a factor in reducing the quality of life of patients with chronic pancreatitis. ( 30448792 )
2018
4
Ascariasis seen by videocapsule endoscopy. ( 29222943 )
2018
5
Gallbladder ascariasis in Kosovo - focus on ultrasound and conservative therapy: a case series. ( 29329599 )
2018
6
A Worm Hole: Liver Abscess in Ascariasis. ( 29518367 )
2018
7
EUS of pancreatic ascariasis. ( 29523472 )
2018
8
Biliary ascariasis presenting with gangrenous perforation of the gall bladder: report of a case and brief review of literature. ( 29649951 )
2018
9
Gastrointestinal: An unusual cause of biliary colic: Biliary ascariasis. ( 29659086 )
2018
10
High prevalence of ascariasis on two coral atolls in the Solomon Islands. ( 29800343 )
2018
11
Incidental diagnosis of appendiceal ascariasis during colonoscopy. ( 30115571 )
2018
12
Ascariasis as a model to study the helminth/allergy relationships. ( 30295330 )
2018
13
The inner tube sign in Ascariasis. ( 30498923 )
2018
14
Differential diagnosis of gallbladder ascariasis debris: the added value of contrast enhanced ultrasound with high frequency transducer. ( 30534646 )
2018
15
Sources of variability in the measurement of Ascaris lumbricoides infection intensity by Kato-Katz and qPCR. ( 28545561 )
2017
16
You Traveled the World and All You Got Was Ascariasis. ( 29056213 )
2017
17
A multilevel study of the environmental determinants of swine ascariasis in England. ( 29157367 )
2017
18
A Case of Biliary Ascariasis in Korea. ( 29320821 )
2017
19
Biliary ascariasis: mimicker of biliary stent. ( 29905283 )
2017
20
Effect of Ascaris lumbricoides infection on T helper cell type 2 in rural Egyptian children. ( 27022269 )
2016
21
Ascaris lumbricoides Infection Following School-Based Deworming in Western Kenya: Assessing the Role of Pupils' School and Home Water, Sanitation, and Hygiene Exposures. ( 26903608 )
2016
22
FACTORS ASSOCIATED WITH THE PREVALENCE OF ASCARIS LUMBRICOIDES INFECTION AMONG PRESCHOOL CHILDREN IN A PLANTATION COMMUNITY, KANDY DISTRICT, SRI LANKA. ( 29634161 )
2016
23
OVERDIAGNOSIS OF COELIAC DISEASE IN A PATIENT WITH ASCARIASIS AND GIARDIASIS. ( 29889407 )
2016
24
Hepatobiliary and pancreatic ascariasis-sonographic pictorial essay on four pediatric cases with acute biliary colic. ( 26690772 )
2016
25
A Cross-Sectional Study of Ascaris lumbricoides Infection in a Rural Community in Ebonyi State, Nigeria: Prevalence and Risk Factors. ( 26576362 )
2015
26
Pancreatic ascariasis with periampullary carcinoma. ( 25709954 )
2015
27
Massive hepatobiliary ascariasis at autopsy. ( 25878238 )
2015
28
Ascariasis as a cause of hepatic abscess: A report of 3 cases. ( 26068350 )
2015
29
Ascaris lumbricoides infection in urban schoolchildren: specific IgE and IL-10 production. ( 23648101 )
2014
30
Detecting and Accommodating Outliers in Meta-Analysis for Evaluating Effect of Albendazole on Ascaris lumbricoides Infection. ( 25031857 )
2014
31
Ascaris lumbricoides infection and parasite load are associated with asthma in children. ( 25022300 )
2014
32
Ascaris lumbricoides infection and its relation to environmental factors in the Mbeya region of Tanzania, a cross-sectional, population-based study. ( 24643023 )
2014
33
Ascariasis of gallbladder: a rare case report and a review of the literature. ( 24253312 )
2014
34
Wandering biliary ascariasis with hepatic abscess in a postmenopausal woman. ( 25481604 )
2014
35
Diagnosis of Ascaris lumbricoides infection using capsule endoscopy. ( 23596544 )
2013
36
Ascariasis as an unexpected cause of acute pancreatitis with cholangitis: a rare case report from urban area. ( 23306343 )
2013
37
Images in clinical medicine. Obstructive ileal ascariasis. ( 23465104 )
2013
38
Peritoneal ascariasis presenting as granulomatous peritonitis and omental cyst. ( 25046891 )
2013
39
Coincident diagnosis of a pulmonary abscess and ascaris lumbricoides infection: a possible causal connection? ( 22821292 )
2012
40
Severity of atopic dermatitis and Ascaris lumbricoides infection: an evaluation of CCR4+ and CXCR3+ helper T cell frequency. ( 23295884 )
2012
41
Differential changes in expression of intestinal antimicrobial peptide genes during Ascaris lumbricoides infection in Zambian adults do not respond to helminth eradication. ( 21357944 )
2011
42
Analysis of clinical symptoms and selected hematological indices in hospitalized children with Ascaris lumbricoides infection from the northeastern region of Poland. ( 21634234 )
2011
43
Ascaris lumbricoides infection causing respiratory distress after coronary artery bypass grafting. ( 19803729 )
2010
44
Ascaris lumbricoides infection: an unexpected cause of pancreatitis in a western Mediterranean country. ( 20795455 )
2010
45
Intestinal ascariasis in children. ( 20143068 )
2010
46
Management of biliary ascariasis in children living in an endemic area. ( 20225180 )
2010
47
Association between total immunoglobulin E and antibody responses to naturally acquired Ascaris lumbricoides infection and polymorphisms of immune system-related LIG4, TNFSF13B and IRS2 genes. ( 19604268 )
2009
48
Molecular diagnosis of ascariasis from human feces and description of a new Ascaris sp. genotype in Brazil. ( 19406577 )
2009
49
Biliary ascariasis in the Indian subcontinent: a study of 42 cases. ( 19568577 )
2009
50
Antibody responses and resistance against Ascaris lumbricoides infection among Venezuelan rural children: the influence of ethnicity. ( 18453627 )
2008

Variations for Ascaris Lumbricoides Infection

Expression for Ascaris Lumbricoides Infection

Search GEO for disease gene expression data for Ascaris Lumbricoides Infection.

Pathways for Ascaris Lumbricoides Infection

Pathways related to Ascaris Lumbricoides Infection according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 CXCL8 IFNG IL13 IL1B IL5 IRS2
2
Show member pathways
13.48 CXCL8 IFNG IL13 IL1B IL5 TNFSF13B
3
Show member pathways
13.33 CXCL8 IFNG IL13 IL1B IL5 IRS2
4
Show member pathways
13.23 CXCL8 IL13 IL1B IL5 TNFSF13B
5
Show member pathways
13.15 CXCL8 IFNG IL13 IL1B IL5 IRS2
6
Show member pathways
13.13 CXCL8 IL13 IL1B IL5 TNFSF13B
7 12.68 CXCL8 IFNG IL13 IL5
8
Show member pathways
12.67 CXCL8 IFNG IL13 IL1B IL5 TNFSF13B
9
Show member pathways
12.65 CXCL8 IFNG IL13 IL1B
10
Show member pathways
12.47 IFNG IL13 IL1B IL5
11
Show member pathways
12.3 IL13 IL1B IL5
12
Show member pathways
12.28 IFNG IL1B IL5
13
Show member pathways
12.28 IFNG IL13 IL5 TSLP
14
Show member pathways
12.17 CXCL8 IFNG IL1B
15
Show member pathways
12.13 CXCL8 IFNG IL13 IL1B IL5
16
Show member pathways
12.12 CXCL8 IFNG IL13 IL1B IL5
17
Show member pathways
12.07 CXCL8 IFNG IL1B
18 12.06 CXCL8 IL13 IL1B
19
Show member pathways
11.93 IFNG IL13 IL1B
20
Show member pathways
11.92 IL13 IL1B IL5
21 11.9 CXCL8 IFNG IL1B TNFSF13B
22 11.88 CXCL8 IL13 IL1B
23 11.84 CXCL8 IFNG IL1B
24 11.8 CXCL8 IFNG IL1B
25 11.79 CXCL8 IL1B TNFSF13B
26
Show member pathways
11.75 CXCL8 IFNG IL13 IL1B IL5 TNFSF13B
27 11.73 CXCL8 IFNG IL1B
28 11.73 CXCL8 IFNG IL1B TNFSF13B
29
Show member pathways
11.67 CXCL8 IFNG IL5
30 11.65 CXCL8 IFNG IL13 IL5
31 11.63 IFNG IL13 IL1B
32
Show member pathways
11.57 CXCL8 IFNG IL1B
33 11.47 CXCL8 IL13 IL1B IL5
34 11.45 CXCL8 IL13 IL1B
35 11.44 CXCL8 IFNG IL1B
36 11.4 IFNG IL13 IL5
37 11.38 CXCL8 TSLP
38 11.36 IFNG IL1B
39 11.35 CXCL8 IFNG
40 11.26 IFNG IL1B
41 11.26 IFNG IL13 IL1B IL5 TSLP
42 11.23 IFNG IL1B
43 11.21 IFNG IL5
44 11.13 IFNG IL13
45 11.13 IFNG IL13 IL5
46 11.07 IFNG IL1B
47 10.95 CXCL8 IL13 IL1B IL5 TNFSF13B
48 10.92 IFNG IL13 IL1B IL5
49 10.87 CXCL8 IL13 IL1B IL5 TNFSF13B
50 10.53 IFNG IL13 IL1B IL5 TSLP

GO Terms for Ascaris Lumbricoides Infection

Cellular components related to Ascaris Lumbricoides Infection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CXCL8 IFNG IL13 IL1B IL5 TNFSF13B
2 extracellular space GO:0005615 9.17 CXCL8 IFNG IL13 IL1B IL5 TNFSF13B

Biological processes related to Ascaris Lumbricoides Infection according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.73 CXCL8 IL13 IL1B IL5
2 positive regulation of cell proliferation GO:0008284 9.73 IFNG IL1B IL5 IRS2 TNFSF13B TSLP
3 cytokine-mediated signaling pathway GO:0019221 9.71 CXCL8 IL13 IL1B IL5
4 MAPK cascade GO:0000165 9.7 IL1B IL5 IRS2
5 immune response GO:0006955 9.63 CXCL8 IFNG IL13 IL1B IL5 TNFSF13B
6 positive regulation of nitric oxide biosynthetic process GO:0045429 9.54 IFNG IL1B
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.54 IFNG IL13 TSLP
8 interleukin-7-mediated signaling pathway GO:0038111 9.51 IRS2 TSLP
9 response to gamma radiation GO:0010332 9.49 IL1B LIG4
10 positive regulation of neutrophil chemotaxis GO:0090023 9.48 CXCL8 IL1B
11 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.46 IFNG IL1B
12 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 IFNG IL1B
13 positive regulation of B cell proliferation GO:0030890 9.26 IL13 IL5 IRS2 TNFSF13B
14 regulation of signaling receptor activity GO:0010469 9.17 CXCL8 IFNG IL13 IL1B IL5 TNFSF13B

Molecular functions related to Ascaris Lumbricoides Infection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CXCL8 IFNG IL13 IL1B IL5 TNFSF13B

Sources for Ascaris Lumbricoides Infection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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