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MCID: ASC003
MIFTS: 31

Ascending Cholangitis

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Ascending Cholangitis

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MalaCards integrated aliases for Ascending Cholangitis:

Name: Ascending Cholangitis 12 15 71

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:14270
NCIt 49 C35372
SNOMED-CT 67 26918003
ICD10 32 K83.0
UMLS 71 C0311273
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Summaries for Ascending Cholangitis

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MalaCards based summary : Ascending Cholangitis is related to cholangitis and biliary atresia. An important gene associated with Ascending Cholangitis is PKHD1 (PKHD1 Ciliary IPT Domain Containing Fibrocystin/Polyductin), and among its related pathways/superpathways is Folate Metabolism. The drugs Oxaliplatin and Irinotecan have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and small intestine.

Wikipedia : 74 Ascending cholangitis, also known as acute cholangitis or simply cholangitis, is inflammation of the... more...

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Related Diseases for Ascending Cholangitis

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Diseases related to Ascending Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 260)
# Related Disease Score Top Affiliating Genes
1 cholangitis 30.9 GPT F2 CRP ALB
2 biliary atresia 30.8 GPT F2 ALB
3 intestinal obstruction 30.3 GPT CRP ALB
4 cholelithiasis 30.2 GPT CRP ALB
5 obstructive jaundice 30.1 GPT F2 CRP ALB
6 cholecystitis 30.1 GPT F2 ALB
7 peritonitis 29.9 F2 CRP ALB
8 intussusception 29.7 CRP ALB
9 portal hypertension 29.7 PKHD1 GPT F2 ALB
10 volvulus of midgut 29.6 GPT F2 CRP ALB
11 respiratory failure 29.6 GPT F2 CRP ALB
12 thrombocytopenia 29.4 GPT F2 CRP ALB
13 acute cholangitis 28.1 GPT GGTLC3 GGT2 F2 CRP ALB
14 choledocholithiasis 28.1 GPT GGTLC3 GGT2 F2 CRP ALB
15 hepatoportal sclerosis 10.5 GPT F2
16 pyridoxine deficiency anemia 10.4 GPT F2
17 liver leiomyosarcoma 10.4 GPT F2
18 orbital osteomyelitis 10.4 F2 CRP
19 small intestine diverticulitis 10.4 F2 CRP
20 caroli disease 10.4 PKHD1 BSCL2
21 tinea unguium 10.4 GPT CRP
22 synovial angioma 10.4 F2 CRP
23 renal pelvis squamous cell carcinoma 10.4 F2 CRP
24 blue toe syndrome 10.4 F2 CRP
25 cavernous sinus thrombosis 10.4 F2 CRP
26 lemierre's syndrome 10.4 F2 CRP
27 dipetalonemiasis 10.4 GPT ALB
28 marantic endocarditis 10.4 F2 CRP
29 intracranial sinus thrombosis 10.4 F2 CRP
30 polycystic kidney disease 4 10.3 PKHD1 ALB
31 cholesterol embolism 10.3 F2 CRP
32 heterophyiasis 10.3 GPT ALB
33 large intestine lipoma 10.3 GPT CRP
34 lipoma of colon 10.3 GPT CRP
35 branch retinal artery occlusion 10.3 F2 CRP
36 dicrocoeliasis 10.3 GPT ALB
37 non-a-e hepatitis 10.3 F2 ALB
38 antipyrine metabolism 10.3 F2 ALB
39 intracranial embolism 10.3 F2 CRP
40 mastoiditis 10.3 F2 CRP
41 fournier gangrene 10.3 F2 ALB
42 central retinal artery occlusion 10.3 F2 CRP
43 intestinal tuberculosis 10.3 CRP ALB
44 chronic duodenal ileus 10.3 CRP ALB
45 nasopharyngitis 10.3 GPT CRP
46 hypertensive encephalopathy 10.3 F2 ALB
47 peptic ulcer perforation 10.3 CRP ALB
48 tuberculous peritonitis 10.3 CRP ALB
49 babesiosis 10.2 GPT ALB
50 critical illness polyneuropathy 10.2 CRP ALB

Graphical network of the top 20 diseases related to Ascending Cholangitis:



Diseases related to Ascending Cholangitis
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Symptoms & Phenotypes for Ascending Cholangitis

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Drugs & Therapeutics for Ascending Cholangitis

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Drugs for Ascending Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 1 61825-94-3 5310940 9887054 6857599 43805
2
Irinotecan Approved, Investigational Phase 1 97682-44-5, 100286-90-6 60838
3
leucovorin Approved Phase 1 58-05-9 6006 143
4
Fluorouracil Approved Phase 1 51-21-8 3385
5
Pancrelipase Approved, Investigational Phase 1 53608-75-6
6 Antihypertensive Agents Phase 1
7 topoisomerase I inhibitors Phase 1
8 Topoisomerase Inhibitors Phase 1
9 Veratrum Alkaloids Phase 1
10 pancreatin Phase 1
11
Neomycin Approved, Vet_approved 1404-04-2 8378
12 Acidophilus
13 Anti-Bacterial Agents
14 Anti-Infective Agents
15 Liver Extracts
16
Bilirubin 635-65-4, 69853-43-6 5280352 21252250

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase I Study of FOLFIRINOX Plus IPI-926 for Advanced Pancreatic Adenocarcinoma Completed NCT01383538 Phase 1 FOLFIRINOX, IPI-926
2 Use of Probiotics to Prevent Cholangitis in Children With Biliary Atresia Completed NCT00166868 Lactobacillus casei rhamnosus (Lcr35);Neomycin
3 COMPLICATIONS OF ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY- AN INDIAN PERSPECTIVE Active, not recruiting NCT04062617
4 Intestinal Microbiome Composition in Infants With Biliary Atresia Not yet recruiting NCT03890536

Search NIH Clinical Center for Ascending Cholangitis

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Genetic Tests for Ascending Cholangitis

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Anatomical Context for Ascending Cholangitis

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MalaCards organs/tissues related to Ascending Cholangitis:

40
Liver, Kidney, Small Intestine, Heart, Colon, Pancreas, Bone
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Publications for Ascending Cholangitis

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Articles related to Ascending Cholangitis:

(show top 50) (show all 311)
# Title Authors PMID Year
1
Biliary Fascioliasis in Chronic Calcific Pancreatitis Presenting with Ascending Cholangitis and Biliary Stricture. 61
31762732 2019
2
Hepatic artery pseudoaneurysm following percutaneous transhepatic cholangiogram: an extremely rare complication. 61
31302620 2019
3
Case 265: Lemmel Syndrome or Biliary Obstruction Due to a Periampullary Duodenal Diverticulum. 61
30998446 2019
4
The role of imaging in determining prognosis for primary sclerosing cholangitis: A systematic review. 61
31044745 2019
5
Case 265. 61
30571455 2019
6
Endoscopic Retrograde Cholangio-Pancreatography-Obtained Bile Culture Can Guide Antibiotic Therapy in Acute Cholangitis. 61
30282078 2019
7
"Primary bacterial culture of bile and pancreatic juice in tumor related jaundice (TROJ) - is ascending cholangitis always our fault?" 61
30621478 2018
8
Self-expanding metal stent procedure for afferent loop syndrome with ascending cholangitis caused by remnant gastric cancer: A case report. 61
30557964 2018
9
Unexpected cause of severe ascending cholangitis in a patient with chronic calculous cholecystitis. 61
30150354 2018
10
Detection of Cytomegalovirus in Liver Tissue by Polymerase Chain Reaction in Infants With Neonatal Cholestasis. 61
29389827 2018
11
Abnormal presentation of ascending cholangitis. 61
29881588 2018
12
Surgeon-performed endoscopic retrograde cholangiopancreatography. Outcomes of 2392 procedures at two tertiary care centers. 61
29273876 2018
13
Mucinous cystic neoplasm of the liver with extrahepatic growth presenting with ascending cholangitis diagnosed by endoscopic ultrasound features: a case report. 61
29444709 2018
14
Stone-Induced Purulent Choledocoduodenal Fistula Presenting with Ascending Cholangitis. 61
30214909 2018
15
Gallbladder Dysfunction: Cholecystitis, Choledocholithiasis, Cholangitis, and Biliary Dyskinesia. 61
29132521 2017
16
The Impact of Cholecystectomy After Endoscopic Sphincterotomy for Complicated Gallstone Disease. 61
28809384 2017
17
Ascending cholangitis: rare presentation of a ruptured right-sided renal angiomyolipoma. 61
29026516 2017
18
Pediatric types I and VI choledochal cysts complicated with acute pancreatitis and spontaneous perforation: A case report and literature review. 61
29049233 2017
19
Acute cholangitis: current concepts. 61
28337833 2017
20
Ascending Cholangitis due to Heavy Lifting. 61
29033769 2017
21
Clinical significance of liver histology on outcomes in biliary atresia. 61
27717116 2017
22
Ascending Cholangitis secondary to migrated embolization coil of gastroduodenal artery pseudo-aneurysm a case report. 61
28330448 2017
23
A Long-Term Survivor of Metastatic Pancreatic Adenocarcinoma: Free of Recurrence 12 Years After Treatment of Oligometastatic Disease. 61
28293485 2017
24
Management of suspected common bile duct stone: diagnostic yield of current guidelines. 61
27914763 2017
25
A unique case of ascending cholangitis. 61
27157828 2016
26
Accuracy of ASGE criteria for the prediction of choledocholithiasis. 61
27063334 2016
27
Children post liver transplantation hospitalized with fever are at a high risk for bacterial infections. 61
26989885 2016
28
Risk of Biliary Events After Selective Cholecystectomy During Biliopancreatic Diversion with Duodenal Switch. 61
26156307 2016
29
Implantation of a Tissue-Engineered Neo-Bile Duct in Domestic Pigs. 61
26684913 2016
30
Double pigtail for preventing ascending cholangitis after endoscopic ultrasonography-guided choledochoduodenostomy with lumen-apposing metal stent. 61
26354292 2016
31
Magnetic resonance cholangiography: Current and future perspectives. 61
26275724 2015
32
Laparoscopy-assisted transgastric endoscopic retrograde cholangiopancreatography in bariatric Roux-en-Y gastric bypass patients. 61
26528502 2015
33
Superiority of 10-mm-wide balloon over 8-mm-wide balloon in papillary dilation for bile duct stones: A matched cohort study. 61
26228364 2015
34
Cholangitis Secondary to Food Material Impaction in the Common Bile Duct through a Choledochoduodenal Fistula. 61
26064830 2015
35
Meta-analysis of Duct-to-duct versus Roux-en-Y biliary reconstruction following liver transplantation for primary sclerosing cholangitis. 61
25557556 2015
36
Rotational assisted endoscopic retrograde cholangiopancreatography in patients with reconstructive gastrointestinal surgical anatomy. 61
25789100 2015
37
Unusual liver abscess secondary to ingested foreign body: laparoscopic management. 61
26017106 2015
38
Endoscopic retrograde cholangiopancreatography for suspected choledocholithiasis: From guidelines to clinical practice. 61
25685269 2015
39
Percutaneous jejunostomy through the liver parenchyma for palliation of afferent loop syndrome. 61
25433418 2015
40
Laparoscopy assisted transjejunal endoscopic retrograde cholangiography for treatment of intrahepatic duct stones in a post Roux-en-Y patient. 61
25630013 2015
41
Totally laparoscopic pancreaticoduodenectomy for pancreatic head cancer with involvement of the superior mesenteric vein-portal vein confluence. 61
24841345 2014
42
Mind the sump! - diagnostic challenge of a rare complication of choledochoduodenostomy. 61
25520606 2014
43
Choledochal cyst mimicking Mirizzi's syndrome A case report. 61
25600242 2014
44
Successful management of hepatic mucormycosis in an acute lymphoblastic leukaemia patient: a case report and review of the literature. 61
24635874 2014
45
Choledochal cyst mimicking Mirizzi's syndrome: a case report. 61
25336283 2014
46
Surgical and nonsurgical management of gallstones. 61
24866215 2014
47
Antireflux stents to reduce the risk of cholangitis in patients with malignant biliary strictures: a randomized trial. 61
24477367 2014
48
Cellulomonas, an emerging pathogen: a case report and review of the literature. 61
24228825 2014
49
Recurrent ascending cholangitis due to small intestinal bacterial overgrowth, gastrointestinal dysmotility and an afferent loop. 61
28839739 2013
50
Biliary drainage method and temporal trends in patients admitted with cholangitis: a national audit. 61
24078935 2013
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Variations for Ascending Cholangitis

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Expression for Ascending Cholangitis

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Search GEO for disease gene expression data for Ascending Cholangitis.
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Pathways for Ascending Cholangitis

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Pathways related to Ascending Cholangitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Folate Metabolism 1
Show member pathways
 11.26 GGT2 F2 CRP ALB
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GO Terms for Ascending Cholangitis

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Cellular components related to Ascending Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 asymmetric synapse GO:0032279 8.62 SNAP47 CHRM3

Biological processes related to Ascending Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukotriene D4 biosynthetic process GO:1901750 8.96 GGTLC3 GGT2
2 glutathione catabolic process GO:0006751 8.62 GGTLC3 GGT2

Molecular functions related to Ascending Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione hydrolase activity GO:0036374 8.62 GGTLC3 GGT2
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Sources for Ascending Cholangitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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