MCID: ASC003
MIFTS: 32

Ascending Cholangitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Ascending Cholangitis

MalaCards integrated aliases for Ascending Cholangitis:

Name: Ascending Cholangitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14270
ICD10 33 K83.0
NCIt 50 C35372
SNOMED-CT 68 26918003
UMLS 73 C0311273

Summaries for Ascending Cholangitis

MalaCards based summary : Ascending Cholangitis is related to choledocholithiasis and polycystic kidney disease 3 with or without polycystic liver disease. An important gene associated with Ascending Cholangitis is HPCA (Hippocalcin), and among its related pathways/superpathways are Cell surface interactions at the vascular wall and Syndecan-1-mediated signaling events. The drugs Neomycin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and bone, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 76 Ascending cholangitis, also known as acute cholangitis or simply cholangitis, is an infection of the... more...

Related Diseases for Ascending Cholangitis

Diseases related to Ascending Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 choledocholithiasis 29.6 ALB F2
2 polycystic kidney disease 3 with or without polycystic liver disease 10.7 PKDREJ PRKD1
3 cholangitis 10.6
4 pyelitis 10.6 CHRM3 PKDREJ
5 orbital cyst 10.5 F2 PKDREJ
6 giant hemangioma 10.3 F2 TGFB1
7 antipyrine metabolism 10.3 ALB F2
8 non-a-e hepatitis 10.2 ALB F2
9 fournier gangrene 10.2 ALB F2
10 abdominal tuberculosis 10.2 ALB F2
11 cholecystolithiasis 10.2 CCK TGFB1
12 biliary atresia 10.2
13 orthostatic proteinuria 10.2 ALB C3
14 kwashiorkor 10.2 ALB F2
15 hepatic tuberculosis 10.2 ALB F2
16 diffuse scleroderma 10.2 TGFB1 TNFRSF25
17 paralytic ileus 10.2 ALB CCK
18 occupational dermatitis 10.1 ALB C3
19 hepatic coma 10.1 ALB F2
20 splenic disease 10.1 ALB F2
21 esophageal varix 10.1 ALB F2
22 hypersplenism 10.1 ALB F2
23 intussusception 10.1
24 hepatitis 10.1
25 compartment syndrome 10.0 ALB F2
26 kidney hypertrophy 10.0 ALB TGFB1
27 hemorrhagic fever 10.0 ALB F2
28 hepatorenal syndrome 10.0 ALB F2
29 autosomal dominant polycystic kidney disease 9.9 ALB PKDREJ PRKD1
30 hypersensitivity vasculitis 9.9 C3 MPO
31 analbuminemia 9.9 ALB F2
32 cholelithiasis 9.9
33 pancreatitis 9.9
34 henoch-schoenlein purpura 9.9 C3 MPO
35 hepatic vascular disease 9.8 ALB F2
36 dysfibrinogenemia 9.8 ALB F2
37 chronic maxillary sinusitis 9.8 C3 MPO
38 rapidly progressive glomerulonephritis 9.8 MPO TGFB1
39 thrombocytopenia 9.8
40 mucositis 9.8
41 obstructive jaundice 9.8
42 angiomyolipoma 9.8
43 kidney angiomyolipoma 9.8
44 afferent loop syndrome 9.8
45 gastroduodenitis 9.8
46 aneurysm 9.8
47 bile duct disease 9.7 ALB CCK F2
48 pasteurellosis 9.7 ALB MPO
49 biliary tract disease 9.7 ALB CCK F2
50 cholecystitis 9.7 ALB CCK F2

Graphical network of the top 20 diseases related to Ascending Cholangitis:



Diseases related to Ascending Cholangitis

Symptoms & Phenotypes for Ascending Cholangitis

MGI Mouse Phenotypes related to Ascending Cholangitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.7 ALB BSG C3 CCK CHRM3 TGFB1
2 homeostasis/metabolism MP:0005376 9.61 ALB C3 CCK CHRM3 F2 HPCA
3 muscle MP:0005369 9.1 MPO PRKD1 TGFB1 ALB C3 CHRM3

Drugs & Therapeutics for Ascending Cholangitis

Drugs for Ascending Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Neomycin Approved, Vet_approved Not Applicable 1404-04-2 8378
2 Anti-Bacterial Agents Not Applicable
3 Anti-Infective Agents Not Applicable
4 Acidophilus Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Probiotics to Prevent Cholangitis in Children With Biliary Atresia After the Kasai Portoenterostomy Completed NCT00166868 Not Applicable Lactobacillus casei rhamnosus (Lcr35);Neomycin

Search NIH Clinical Center for Ascending Cholangitis

Genetic Tests for Ascending Cholangitis

Anatomical Context for Ascending Cholangitis

MalaCards organs/tissues related to Ascending Cholangitis:

41
Small Intestine, Liver, Bone

Publications for Ascending Cholangitis

Articles related to Ascending Cholangitis:

(show all 47)
# Title Authors Year
1
Mucinous cystic neoplasm of the liver with extrahepatic growth presenting with ascending cholangitis diagnosed by endoscopic ultrasound features: a case report. ( 29444709 )
2018
2
Abnormal presentation of ascending cholangitis. ( 29881588 )
2018
3
Ascending cholangitis: rare presentation of a ruptured right-sided renal angiomyolipoma. ( 29026516 )
2017
4
Ascending Cholangitis due to Heavy Lifting. ( 29033769 )
2017
5
Ascending Cholangitis secondary to migrated embolization coil of gastroduodenal artery pseudo-aneurysm a case report. ( 28330448 )
2017
6
A unique case of ascending cholangitis. ( 27157828 )
2016
7
Double pigtail for preventing ascending cholangitis after endoscopic ultrasonography-guided choledochoduodenostomy with lumen-apposing metal stent. ( 26354292 )
2015
8
Recurrent ascending cholangitis due to small intestinal bacterial overgrowth, gastrointestinal dysmotility and an afferent loop. ( 28839739 )
2013
9
Does the urgency of endoscopic retrograde cholangiopancreatography (ercp)/percutaneous biliary drainage (pbd) impact mortality and disease related complications in ascending cholangitis? (deim-i study). ( 23687602 )
2012
10
Endoscopic management of afferent loop syndrome after a pylorus preserving pancreatoduodenecotomy presenting with obstructive jaundice and ascending cholangitis. ( 22741115 )
2011
11
Endoscopic treatment of acute ascending cholangitis in a patient with Roux-en-Y limb obstruction after a Whipple operation. ( 21170836 )
2010
12
Ascending cholangitis presenting with Lactococcus lactis cremoris bacteraemia: a case report. ( 19126198 )
2009
13
Choledocholithiasis, ascending cholangitis, and gallstone pancreatitis. ( 18570948 )
2008
14
Toxic hepatic injury mimicking ascending cholangitis: is Pyrus amygdaliformis to blame? ( 18787839 )
2008
15
Management of ascending cholangitis. ( 17556149 )
2007
16
New strategy to prevent ascending cholangitis in larger choledochoduodenal fistula. ( 16922901 )
2006
17
Acute ascending cholangitis. ( 15108417 )
2004
18
Ascending cholangitis provokes IL-8 and MCP-1 expression and promotes inflammatory cell infiltration in the cholestatic rat liver. ( 11685687 )
2001
19
Enterococcus hirae enteropathy with ascending cholangitis and pancreatitis in a kitten. ( 10810996 )
2000
20
Acute (ascending) cholangitis. ( 10987108 )
2000
21
Ascending cholangitis as a cause of pyogenic liver abscesses complicated by a gastric submucosal abscess and fistula. ( 10777197 )
2000
22
Further experience with the antireflux valve to prevent ascending cholangitis in biliary atresia. ( 9349766 )
1997
23
An impacted metallic clip at the ampulla causing ascending cholangitis. ( 9165332 )
1997
24
Volvulus of the Roux-en-Y hepaticojejunostomy. A rare complication manifested by recurrent ascending cholangitis. ( 7928157 )
1994
25
The role of endoscopic papillotomy in ascending cholangitis. ( 2053744 )
1991
26
Effectiveness of an intussusceptive antireflux valve to prevent ascending cholangitis after hepatic portojejunostomy in biliary atresia. ( 1895188 )
1991
27
Ascending cholangitis: surgery versus endoscopic or percutaneous drainage. ( 2218872 )
1990
28
Mucosal intussusception to avoid ascending cholangitis. ( 2207590 )
1990
29
Intussusception-type antireflux valve in the Roux-en-Y loop to prevent ascending cholangitis after hepatic portojejunostomy. ( 2313499 )
1990
30
Problems involved in re-laparotomy for congenital biliary atresia: with special reference to postoperative ascending cholangitis. ( 3388986 )
1988
31
The benefit of emergency nasobiliary drain in cholelithiasis with ascending cholangitis, coagulopathy, and thrombocytopenia. ( 3726751 )
1986
32
The valved conduit prevents ascending cholangitis: a follow-up. ( 4087101 )
1985
33
Clinical and experimental studies on ascending cholangitis after Kasai's portoenterostomy for type III congenital bile duct atresia. ( 6511476 )
1984
34
Roux-en-Y on-line intussusception to avoid ascending cholangitis in biliary atresia. ( 6615221 )
1983
35
Cholelithiasis, ascending cholangitis and septicaemia. Report of a case in an 89-year-old woman. ( 6752931 )
1982
36
Ascending cholangitis secondary to a chicken bone lodged at the ampulla of Vater. ( 7013517 )
1981
37
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: measures and control. Invited commentary. ( 741764 )
1978
38
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: measures for control. ( 741763 )
1978
39
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: Measures and control. Invited commentary. ( 741784 )
1978
40
Ascending cholangitis diagnosed by percutaneous hepatic aspiration. ( 1107502 )
1976
41
Ascending cholangitis: an urgent surgical problem. ( 4691603 )
1973
42
Ascending cholangitis after successful surgical repair of biliary atresia. ( 4200280 )
1973
43
The management of ascending cholangitis. 1. Bacteriology and choice of antibiotic. ( 5768332 )
1969
44
The management of ascending cholangitis. II. Practical management and timing of operation. ( 5768333 )
1969
45
Ascending cholangitis. ( 5219417 )
1966
46
Grave ascending cholangitis following cholangiography carried out through the cystic duct infected with E. coli. ( 20990634 )
1946
47
Gall-Bladder Function: With Special Reference to Cholecystogastrostomy and the Absence of Ascending Cholangitis. ( 17866525 )
1931

Variations for Ascending Cholangitis

Expression for Ascending Cholangitis

Search GEO for disease gene expression data for Ascending Cholangitis.

Pathways for Ascending Cholangitis

Pathways related to Ascending Cholangitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.38 BSG F2 TGFB1
2 9.85 BSG TGFB1

GO Terms for Ascending Cholangitis

Cellular components related to Ascending Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 ALB C3 CCK F2 MPO TGFB1
2 extracellular region GO:0005576 9.5 ALB C3 CCK F2 MPO TGFB1
3 blood microparticle GO:0072562 8.92 ALB C3 F2 TGFB1

Biological processes related to Ascending Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.43 C3 F2 TGFB1
2 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.37 PRKD1 TGFB1
3 positive regulation of vascular endothelial growth factor production GO:0010575 9.32 C3 TGFB1
4 positive regulation of collagen biosynthetic process GO:0032967 9.16 F2 TGFB1
5 positive regulation of protein localization to nucleus GO:1900182 8.96 F2 TGFB1
6 inflammatory response GO:0006954 8.92 C3 PRKD1 TGFB1 TNFRSF25

Sources for Ascending Cholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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