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MCID: ASC003
MIFTS: 35

Ascending Cholangitis

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Ascending Cholangitis

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MalaCards integrated aliases for Ascending Cholangitis:

Name: Ascending Cholangitis 12 15 72

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:14270
NCIt 50 C35372
SNOMED-CT 68 26918003
ICD10 33 K83.0
UMLS 72 C0311273
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Summaries for Ascending Cholangitis

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MalaCards based summary : Ascending Cholangitis is related to cholangitis and biliary atresia. An important gene associated with Ascending Cholangitis is HPCA (Hippocalcin), and among its related pathways/superpathways are Cell surface interactions at the vascular wall and Selenium Micronutrient Network. The drugs Oxaliplatin and Pancrelipase have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and pancreas, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 75 Ascending cholangitis, also known as acute cholangitis or simply cholangitis, is inflammation of the... more...

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Related Diseases for Ascending Cholangitis

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Diseases related to Ascending Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 cholangitis 30.4 GPT F2 CRP ALB
2 biliary atresia 30.1 TGFB1 GPT ALB
3 cholelithiasis 29.8 GPT CCK ALB
4 choledocholithiasis 29.7 GPT F2 ALB
5 obstructive jaundice 29.7 GPT F2 CRP ALB
6 portal hypertension 29.6 GPT F2 ALB
7 cholecystitis 29.2 GPT F2 CCK ALB
8 peritonitis 28.6 MPO F2 CRP ALB
9 malignant otitis externa 10.5 F2 CRP
10 chronic thromboembolic pulmonary hypertension 10.4 F2 CRP
11 acquired angioedema 10.4 CRP C3
12 hepatoportal sclerosis 10.4 GPT F2
13 acute maxillary sinusitis 10.4 CRP C3
14 acalculous cholecystitis 10.4 CRP CCK
15 blue toe syndrome 10.4 F2 CRP
16 paralytic ileus 10.4 CRP CCK
17 ischemic neuropathy 10.4 F2 CRP
18 pyelitis 10.3 CRP CHRM3
19 non-a-e hepatitis 10.3 F2 ALB
20 pyomyositis 10.3 GPT CRP
21 antipyrine metabolism 10.3 F2 ALB
22 giant hemangioma 10.3 TGFB1 F2
23 hepatitis d 10.3 GPT F2
24 epstein-barr virus hepatitis 10.3 F2 ALB
25 fournier gangrene 10.2 F2 ALB
26 cholecystolithiasis 10.2 TGFB1 CCK
27 intussusception 10.2
28 orthostatic proteinuria 10.2 C3 ALB
29 intestinal obstruction 10.1
30 gastrointestinal tuberculosis 10.1 CRP ALB
31 pyuria 10.1 CRP ALB
32 splenic disease 10.1 F2 ALB
33 peripheral vertigo 10.1 F2 CRP
34 esophageal varix 10.1 F2 ALB
35 diffuse scleroderma 10.1 TNFRSF25 TGFB1
36 pancreatic cancer 10.1
37 gallbladder disease 1 10.1
38 pancreatitis 10.1
39 afferent loop syndrome 10.1
40 overgrowth syndrome 10.1
41 decubitus ulcer 10.0 CRP ALB
42 kidney hypertrophy 10.0 TGFB1 ALB
43 tuberculous peritonitis 10.0 CRP ALB
44 autoimmune disease of musculoskeletal system 10.0 TNFRSF25 CRP C3
45 abdominal tuberculosis 9.9 F2 CRP ALB
46 biliary tract disease 9.9 F2 CCK ALB
47 mononeuritis multiplex 9.9 MPO CRP
48 aortitis 9.9 MPO CRP
49 intermittent claudication 9.9 F2 CRP ALB
50 typhoid fever 9.9 F2 CRP ALB

Graphical network of the top 20 diseases related to Ascending Cholangitis:



Diseases related to Ascending Cholangitis
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Symptoms & Phenotypes for Ascending Cholangitis

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MGI Mouse Phenotypes related to Ascending Cholangitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.76 ALB BSG C3 CACNA1E CCK CHRM3
2 homeostasis/metabolism MP:0005376 9.65 ALB C3 CACNA1E CCK CHRM3 CRP
3 muscle MP:0005369 9.1 ALB C3 CHRM3 MPO PRKD1 TGFB1
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Drugs & Therapeutics for Ascending Cholangitis

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Drugs for Ascending Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 1 61825-94-3 5310940 9887054 43805 6857599
2
Pancrelipase Approved, Investigational Phase 1 53608-75-6
3
Fluorouracil Approved Phase 1 51-21-8 3385
4
leucovorin Approved Phase 1 58-05-9 143 6006
5
Irinotecan Approved, Investigational Phase 1 100286-90-6, 97682-44-5 60838
6 topoisomerase I inhibitors Phase 1
7 pancreatin Phase 1
8 Topoisomerase Inhibitors Phase 1
9 Antihypertensive Agents Phase 1
10 Veratrum Alkaloids Phase 1
11
Neomycin Approved, Vet_approved 1404-04-2 8378
12 Acidophilus
13 Anti-Bacterial Agents
14 Anti-Infective Agents
15 Liver Extracts
16
Bilirubin 635-65-4, 69853-43-6 5280352 21252250

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase I Study of FOLFIRINOX Plus IPI-926 for Advanced Pancreatic Adenocarcinoma Completed NCT01383538 Phase 1 FOLFIRINOX, IPI-926
2 Use of Probiotics to Prevent Cholangitis in Children With Biliary Atresia Completed NCT00166868 Lactobacillus casei rhamnosus (Lcr35);Neomycin
3 COMPLICATIONS OF ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY- AN INDIAN PERSPECTIVE Active, not recruiting NCT04062617
4 Intestinal Microbiome Composition in Infants With Biliary Atresia Not yet recruiting NCT03890536

Search NIH Clinical Center for Ascending Cholangitis

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Genetic Tests for Ascending Cholangitis

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Anatomical Context for Ascending Cholangitis

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MalaCards organs/tissues related to Ascending Cholangitis:

41
Liver, Small Intestine, Pancreas, Kidney, Bone, Colon
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Publications for Ascending Cholangitis

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Articles related to Ascending Cholangitis:

(show top 50) (show all 310)
# Title Authors PMID Year
1
Hepatic artery pseudoaneurysm following percutaneous transhepatic cholangiogram: an extremely rare complication. 38
31302620 2019
2
Case 265: Lemmel Syndrome or Biliary Obstruction Due to a Periampullary Duodenal Diverticulum. 38
30998446 2019
3
The role of imaging in determining prognosis for primary sclerosing cholangitis: A systematic review. 38
31044745 2019
4
Case 265. 38
30571455 2019
5
Endoscopic Retrograde Cholangio-Pancreatography-Obtained Bile Culture Can Guide Antibiotic Therapy in Acute Cholangitis. 38
30282078 2019
6
"Primary bacterial culture of bile and pancreatic juice in tumor related jaundice (TROJ) - is ascending cholangitis always our fault?" 38
30621478 2018
7
Self-expanding metal stent procedure for afferent loop syndrome with ascending cholangitis caused by remnant gastric cancer: A case report. 38
30557964 2018
8
Unexpected cause of severe ascending cholangitis in a patient with chronic calculous cholecystitis. 38
30150354 2018
9
Detection of Cytomegalovirus in Liver Tissue by Polymerase Chain Reaction in Infants With Neonatal Cholestasis. 38
29389827 2018
10
Abnormal presentation of ascending cholangitis. 38
29881588 2018
11
Surgeon-performed endoscopic retrograde cholangiopancreatography. Outcomes of 2392 procedures at two tertiary care centers. 38
29273876 2018
12
Mucinous cystic neoplasm of the liver with extrahepatic growth presenting with ascending cholangitis diagnosed by endoscopic ultrasound features: a case report. 38
29444709 2018
13
Stone-Induced Purulent Choledocoduodenal Fistula Presenting with Ascending Cholangitis. 38
30214909 2018
14
Gallbladder Dysfunction: Cholecystitis, Choledocholithiasis, Cholangitis, and Biliary Dyskinesia. 38
29132521 2017
15
The Impact of Cholecystectomy After Endoscopic Sphincterotomy for Complicated Gallstone Disease. 38
28809384 2017
16
Ascending cholangitis: rare presentation of a ruptured right-sided renal angiomyolipoma. 38
29026516 2017
17
Pediatric types I and VI choledochal cysts complicated with acute pancreatitis and spontaneous perforation: A case report and literature review. 38
29049233 2017
18
Acute cholangitis: current concepts. 38
28337833 2017
19
Ascending Cholangitis due to Heavy Lifting. 38
29033769 2017
20
Clinical significance of liver histology on outcomes in biliary atresia. 38
27717116 2017
21
Ascending Cholangitis secondary to migrated embolization coil of gastroduodenal artery pseudo-aneurysm a case report. 38
28330448 2017
22
A Long-Term Survivor of Metastatic Pancreatic Adenocarcinoma: Free of Recurrence 12 Years After Treatment of Oligometastatic Disease. 38
28293485 2017
23
Management of suspected common bile duct stone: diagnostic yield of current guidelines. 38
27914763 2017
24
A unique case of ascending cholangitis. 38
27157828 2016
25
Children post liver transplantation hospitalized with fever are at a high risk for bacterial infections. 38
26989885 2016
26
Accuracy of ASGE criteria for the prediction of choledocholithiasis. 38
27063334 2016
27
Risk of Biliary Events After Selective Cholecystectomy During Biliopancreatic Diversion with Duodenal Switch. 38
26156307 2016
28
Implantation of a Tissue-Engineered Neo-Bile Duct in Domestic Pigs. 38
26684913 2016
29
Double pigtail for preventing ascending cholangitis after endoscopic ultrasonography-guided choledochoduodenostomy with lumen-apposing metal stent. 38
26354292 2016
30
Magnetic resonance cholangiography: Current and future perspectives. 38
26275724 2015
31
Laparoscopy-assisted transgastric endoscopic retrograde cholangiopancreatography in bariatric Roux-en-Y gastric bypass patients. 38
26528502 2015
32
Superiority of 10-mm-wide balloon over 8-mm-wide balloon in papillary dilation for bile duct stones: A matched cohort study. 38
26228364 2015
33
Cholangitis Secondary to Food Material Impaction in the Common Bile Duct through a Choledochoduodenal Fistula. 38
26064830 2015
34
Meta-analysis of Duct-to-duct versus Roux-en-Y biliary reconstruction following liver transplantation for primary sclerosing cholangitis. 38
25557556 2015
35
Rotational assisted endoscopic retrograde cholangiopancreatography in patients with reconstructive gastrointestinal surgical anatomy. 38
25789100 2015
36
Unusual liver abscess secondary to ingested foreign body: laparoscopic management. 38
26017106 2015
37
Endoscopic retrograde cholangiopancreatography for suspected choledocholithiasis: From guidelines to clinical practice. 38
25685269 2015
38
Percutaneous jejunostomy through the liver parenchyma for palliation of afferent loop syndrome. 38
25433418 2015
39
Laparoscopy assisted transjejunal endoscopic retrograde cholangiography for treatment of intrahepatic duct stones in a post Roux-en-Y patient. 38
25630013 2015
40
Totally laparoscopic pancreaticoduodenectomy for pancreatic head cancer with involvement of the superior mesenteric vein-portal vein confluence. 38
24841345 2014
41
Mind the sump! - diagnostic challenge of a rare complication of choledochoduodenostomy. 38
25520606 2014
42
Choledochal cyst mimicking Mirizzi's syndrome A case report. 38
25600242 2014
43
Successful management of hepatic mucormycosis in an acute lymphoblastic leukaemia patient: a case report and review of the literature. 38
24635874 2014
44
Choledochal cyst mimicking Mirizzi's syndrome: a case report. 38
25336283 2014
45
Surgical and nonsurgical management of gallstones. 38
24866215 2014
46
Antireflux stents to reduce the risk of cholangitis in patients with malignant biliary strictures: a randomized trial. 38
24477367 2014
47
Cellulomonas, an emerging pathogen: a case report and review of the literature. 38
24228825 2014
48
Recurrent ascending cholangitis due to small intestinal bacterial overgrowth, gastrointestinal dysmotility and an afferent loop. 38
28839739 2013
49
Biliary drainage method and temporal trends in patients admitted with cholangitis: a national audit. 38
24078935 2013
50
Failure of sequential biliary stenting for unsuccessful common bile duct stone removal. 38
23772266 2013
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Variations for Ascending Cholangitis

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Expression for Ascending Cholangitis

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Search GEO for disease gene expression data for Ascending Cholangitis.
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Pathways for Ascending Cholangitis

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Pathways related to Ascending Cholangitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cell surface interactions at the vascular wall 66
Show member pathways
 11.58 TGFB1 F2 BSG
2
Selenium Micronutrient Network 1
Show member pathways
 11.26 MPO F2 CRP ALB
3
Syndecan-1-mediated signaling events 1
10.19 TGFB1 BSG
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GO Terms for Ascending Cholangitis

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Cellular components related to Ascending Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 TNFRSF25 TGFB1 MPO F2 CRP CCK
2 axon GO:0030424 9.56 TGFB1 HPCA CCK BSG
3 extracellular space GO:0005615 9.56 TGFB1 MPO GPT F2 CRP CCK
4 blood microparticle GO:0072562 8.92 TGFB1 F2 C3 ALB

Biological processes related to Ascending Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of vascular endothelial growth factor production GO:0010575 9.32 TGFB1 C3
2 positive regulation of protein localization to nucleus GO:1900182 9.26 TGFB1 F2
3 inflammatory response GO:0006954 9.26 TGFB1 PRKD1 CRP C3
4 positive regulation of collagen biosynthetic process GO:0032967 9.16 TGFB1 F2
5 positive regulation of superoxide anion generation GO:0032930 8.62 TGFB1 CRP
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Sources for Ascending Cholangitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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