MCID: ASC003
MIFTS: 37

Ascending Cholangitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Ascending Cholangitis

MalaCards integrated aliases for Ascending Cholangitis:

Name: Ascending Cholangitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14270
ICD10 33 K83.0
NCIt 50 C35372
SNOMED-CT 68 26918003
UMLS 73 C0311273

Summaries for Ascending Cholangitis

MalaCards based summary : Ascending Cholangitis is related to cholecystitis and choledocholithiasis. An important gene associated with Ascending Cholangitis is HPCA (Hippocalcin), and among its related pathways/superpathways are Cell surface interactions at the vascular wall and Selenium Micronutrient Network. The drugs Neomycin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and bone, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 76 Ascending cholangitis, also known as acute cholangitis or simply cholangitis, is inflammation of the... more...

Related Diseases for Ascending Cholangitis

Diseases related to Ascending Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 cholecystitis 29.8 ALB CCK F2
2 choledocholithiasis 29.7 ALB F2
3 cholangitis 10.7
4 biliary atresia 10.3
5 degos 'en cocarde' erythrokeratoderma 10.2
6 antipyrine metabolism 10.1 ALB F2
7 non-a-e hepatitis 10.1 ALB F2
8 orthostatic proteinuria 10.1 ALB C3
9 epstein-barr virus hepatitis 10.1 ALB F2
10 intussusception 10.1
11 fournier gangrene 10.1 ALB F2
12 abdominal tuberculosis 10.1 ALB F2
13 hepatic tuberculosis 10.1 ALB F2
14 kwashiorkor 10.1 ALB F2
15 hepatic coma 10.1 ALB F2
16 infantile liver failure syndrome 1 10.1 ALB F2
17 splenic disease 10.1 ALB F2
18 esophageal varix 10.1 ALB F2
19 retinal vascular occlusion 10.1 CCL2 F2
20 post-thrombotic syndrome 10.0 CCL2 F2
21 hypersplenism 10.0 ALB F2
22 hypersensitivity vasculitis 10.0 C3 MPO
23 compartment syndrome 10.0 ALB F2
24 cerebral aneurysms 10.0 CCL2 MPO
25 cholelithiasis 10.0
26 pancreatitis 10.0
27 hemorrhagic fever 10.0 ALB F2
28 pasteurellosis 10.0 ALB MPO
29 cholecystolithiasis 10.0 CCK TGFB1
30 acute proliferative glomerulonephritis 10.0 CCL2 MPO
31 giant hemangioma 10.0 F2 TGFB1
32 bile duct disease 10.0 ALB CCK F2
33 ulcerative stomatitis 10.0 ALB MPO
34 chronic maxillary sinusitis 10.0 C3 MPO
35 biliary tract disease 10.0 ALB CCK F2
36 hepatorenal syndrome 10.0 ALB F2
37 gastrointestinal system disease 10.0 ALB CCK F2
38 immune system disease 10.0 ALB C3 TNFRSF25
39 diffuse scleroderma 10.0 TGFB1 TNFRSF25
40 chronic monocytic leukemia 10.0 C3 F2 MPO
41 diabetic foot ulcers 9.9 CCL2 TGFB1
42 autosomal dominant polycystic kidney disease 9.9 ALB CCL2 PRKD1
43 celiac disease 1 9.9 ALB CCK TNFRSF25
44 kidney hypertrophy 9.9 ALB TGFB1
45 alcoholic hepatitis 9.9 ALB CCL2 F2
46 hypersensitivity reaction type iii disease 9.9 ALB C3 MPO
47 proliferative glomerulonephritis 9.9 C3 CCL2 MPO
48 peyronie's disease 9.9 CCL2 TGFB1
49 rapidly progressive glomerulonephritis 9.9 MPO TGFB1
50 transient arthritis 9.9 ALB TGFB1

Graphical network of the top 20 diseases related to Ascending Cholangitis:



Diseases related to Ascending Cholangitis

Symptoms & Phenotypes for Ascending Cholangitis

MGI Mouse Phenotypes related to Ascending Cholangitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.7 ALB BSG C3 CCK CHRM3 TGFB1
2 homeostasis/metabolism MP:0005376 9.61 ALB C3 CCK CHRM3 F2 HPCA
3 muscle MP:0005369 9.1 ALB C3 CHRM3 MPO PRKD1 TGFB1

Drugs & Therapeutics for Ascending Cholangitis

Drugs for Ascending Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Neomycin Approved, Vet_approved Not Applicable 1404-04-2 8378
2 Anti-Bacterial Agents Not Applicable
3 Acidophilus Not Applicable
4 Anti-Infective Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Probiotics to Prevent Cholangitis in Children With Biliary Atresia After the Kasai Portoenterostomy Completed NCT00166868 Not Applicable Lactobacillus casei rhamnosus (Lcr35);Neomycin

Search NIH Clinical Center for Ascending Cholangitis

Genetic Tests for Ascending Cholangitis

Anatomical Context for Ascending Cholangitis

MalaCards organs/tissues related to Ascending Cholangitis:

41
Small Intestine, Liver, Bone, Lung, Kidney, Monocytes

Publications for Ascending Cholangitis

Articles related to Ascending Cholangitis:

(show all 49)
# Title Authors Year
1
Mucinous cystic neoplasm of the liver with extrahepatic growth presenting with ascending cholangitis diagnosed by endoscopic ultrasound features: a case report. ( 29444709 )
2018
2
Abnormal presentation of ascending cholangitis. ( 29881588 )
2018
3
Unexpected cause of severe ascending cholangitis in a patient with chronic calculous cholecystitis. ( 30150354 )
2018
4
Stone-Induced Purulent Choledocoduodenal Fistula Presenting with Ascending Cholangitis. ( 30214909 )
2018
5
Ascending cholangitis: rare presentation of a ruptured right-sided renal angiomyolipoma. ( 29026516 )
2017
6
Ascending Cholangitis due to Heavy Lifting. ( 29033769 )
2017
7
Ascending Cholangitis secondary to migrated embolization coil of gastroduodenal artery pseudo-aneurysm a case report. ( 28330448 )
2017
8
A unique case of ascending cholangitis. ( 27157828 )
2016
9
Double pigtail for preventing ascending cholangitis after endoscopic ultrasonography-guided choledochoduodenostomy with lumen-apposing metal stent. ( 26354292 )
2015
10
Recurrent ascending cholangitis due to small intestinal bacterial overgrowth, gastrointestinal dysmotility and an afferent loop. ( 28839739 )
2013
11
Does the urgency of endoscopic retrograde cholangiopancreatography (ercp)/percutaneous biliary drainage (pbd) impact mortality and disease related complications in ascending cholangitis? (deim-i study). ( 23687602 )
2012
12
Endoscopic management of afferent loop syndrome after a pylorus preserving pancreatoduodenecotomy presenting with obstructive jaundice and ascending cholangitis. ( 22741115 )
2011
13
Endoscopic treatment of acute ascending cholangitis in a patient with Roux-en-Y limb obstruction after a Whipple operation. ( 21170836 )
2010
14
Ascending cholangitis presenting with Lactococcus lactis cremoris bacteraemia: a case report. ( 19126198 )
2009
15
Choledocholithiasis, ascending cholangitis, and gallstone pancreatitis. ( 18570948 )
2008
16
Toxic hepatic injury mimicking ascending cholangitis: is Pyrus amygdaliformis to blame? ( 18787839 )
2008
17
Management of ascending cholangitis. ( 17556149 )
2007
18
New strategy to prevent ascending cholangitis in larger choledochoduodenal fistula. ( 16922901 )
2006
19
Acute ascending cholangitis. ( 15108417 )
2004
20
Ascending cholangitis provokes IL-8 and MCP-1 expression and promotes inflammatory cell infiltration in the cholestatic rat liver. ( 11685687 )
2001
21
Enterococcus hirae enteropathy with ascending cholangitis and pancreatitis in a kitten. ( 10810996 )
2000
22
Acute (ascending) cholangitis. ( 10987108 )
2000
23
Ascending cholangitis as a cause of pyogenic liver abscesses complicated by a gastric submucosal abscess and fistula. ( 10777197 )
2000
24
Further experience with the antireflux valve to prevent ascending cholangitis in biliary atresia. ( 9349766 )
1997
25
An impacted metallic clip at the ampulla causing ascending cholangitis. ( 9165332 )
1997
26
Volvulus of the Roux-en-Y hepaticojejunostomy. A rare complication manifested by recurrent ascending cholangitis. ( 7928157 )
1994
27
The role of endoscopic papillotomy in ascending cholangitis. ( 2053744 )
1991
28
Effectiveness of an intussusceptive antireflux valve to prevent ascending cholangitis after hepatic portojejunostomy in biliary atresia. ( 1895188 )
1991
29
Ascending cholangitis: surgery versus endoscopic or percutaneous drainage. ( 2218872 )
1990
30
Mucosal intussusception to avoid ascending cholangitis. ( 2207590 )
1990
31
Intussusception-type antireflux valve in the Roux-en-Y loop to prevent ascending cholangitis after hepatic portojejunostomy. ( 2313499 )
1990
32
Problems involved in re-laparotomy for congenital biliary atresia: with special reference to postoperative ascending cholangitis. ( 3388986 )
1988
33
The benefit of emergency nasobiliary drain in cholelithiasis with ascending cholangitis, coagulopathy, and thrombocytopenia. ( 3726751 )
1986
34
The valved conduit prevents ascending cholangitis: a follow-up. ( 4087101 )
1985
35
Clinical and experimental studies on ascending cholangitis after Kasai's portoenterostomy for type III congenital bile duct atresia. ( 6511476 )
1984
36
Roux-en-Y on-line intussusception to avoid ascending cholangitis in biliary atresia. ( 6615221 )
1983
37
Cholelithiasis, ascending cholangitis and septicaemia. Report of a case in an 89-year-old woman. ( 6752931 )
1982
38
Ascending cholangitis secondary to a chicken bone lodged at the ampulla of Vater. ( 7013517 )
1981
39
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: measures and control. Invited commentary. ( 741764 )
1978
40
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: measures for control. ( 741763 )
1978
41
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: Measures and control. Invited commentary. ( 741784 )
1978
42
Ascending cholangitis diagnosed by percutaneous hepatic aspiration. ( 1107502 )
1976
43
Ascending cholangitis: an urgent surgical problem. ( 4691603 )
1973
44
Ascending cholangitis after successful surgical repair of biliary atresia. ( 4200280 )
1973
45
The management of ascending cholangitis. 1. Bacteriology and choice of antibiotic. ( 5768332 )
1969
46
The management of ascending cholangitis. II. Practical management and timing of operation. ( 5768333 )
1969
47
Ascending cholangitis. ( 5219417 )
1966
48
Grave ascending cholangitis following cholangiography carried out through the cystic duct infected with E. coli. ( 20990634 )
1946
49
Gall-Bladder Function: With Special Reference to Cholecystogastrostomy and the Absence of Ascending Cholangitis. ( 17866525 )
1931

Variations for Ascending Cholangitis

Expression for Ascending Cholangitis

Search GEO for disease gene expression data for Ascending Cholangitis.

Pathways for Ascending Cholangitis

Pathways related to Ascending Cholangitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.75 BSG F2 TGFB1
2
Show member pathways
11.26 ALB CCL2 F2 MPO
3 10.65 CCL2 F2
4 10.39 BSG TGFB1
5 10.16 CCL2 MPO

GO Terms for Ascending Cholangitis

Cellular components related to Ascending Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 ALB C3 CCK CCL2 F2 MPO
2 axon GO:0030424 9.56 BSG CCK HPCA TGFB1
3 extracellular region GO:0005576 9.56 ALB C3 CCK CCL2 F2 MPO
4 blood microparticle GO:0072562 8.92 ALB C3 F2 TGFB1

Biological processes related to Ascending Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.61 C3 F2 TGFB1
2 regulation of signaling receptor activity GO:0010469 9.56 CCK CCL2 F2 TGFB1
3 positive regulation of protein import into nucleus GO:0042307 9.48 PRKD1 TGFB1
4 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.46 PRKD1 TGFB1
5 inflammatory response GO:0006954 9.46 C3 CCL2 PRKD1 TGFB1
6 positive regulation of vascular endothelial growth factor production GO:0010575 9.4 C3 TGFB1
7 positive regulation of collagen biosynthetic process GO:0032967 9.37 F2 TGFB1
8 positive regulation of protein localization to nucleus GO:1900182 9.32 F2 TGFB1
9 cell surface receptor signaling pathway GO:0007166 9.26 BSG CCL2 F2 TNFRSF25
10 positive regulation of apoptotic cell clearance GO:2000427 8.62 C3 CCL2

Sources for Ascending Cholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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