MCID: ASC003
MIFTS: 36

Ascending Cholangitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Ascending Cholangitis

MalaCards integrated aliases for Ascending Cholangitis:

Name: Ascending Cholangitis 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:14270
NCIt 51 C35372
SNOMED-CT 69 26918003
ICD10 34 K83.0
UMLS 74 C0311273

Summaries for Ascending Cholangitis

MalaCards based summary : Ascending Cholangitis is related to cholangitis and biliary atresia. An important gene associated with Ascending Cholangitis is HPCA (Hippocalcin), and among its related pathways/superpathways are Cell surface interactions at the vascular wall and Selenium Micronutrient Network. The drugs Neomycin and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and kidney, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 77 Ascending cholangitis, also known as acute cholangitis or simply cholangitis, is inflammation of the... more...

Related Diseases for Ascending Cholangitis

Diseases related to Ascending Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 cholangitis 30.6 ALB CRP F2 GPT
2 biliary atresia 30.2 ALB GPT TGFB1
3 cholelithiasis 30.0 ALB CCK GPT
4 choledocholithiasis 29.7 ALB F2 GPT
5 cholecystitis 29.5 ALB CCK F2 GPT
6 obstructive jaundice 29.3 ALB CRP F2 GPT
7 hepatoportal sclerosis 10.3 F2 GPT
8 acalculous cholecystitis 10.3 CCK CRP
9 malignant otitis externa 10.2 CRP F2
10 acquired angioedema 10.2 C3 CRP
11 paralytic ileus 10.2 CCK CRP
12 acute maxillary sinusitis 10.2 C3 CRP
13 chronic thromboembolic pulmonary hypertension 10.2 CRP F2
14 pyelitis 10.2 CHRM3 CRP
15 hepatitis d 10.2 F2 GPT
16 pyomyositis 10.2 CRP GPT
17 cholecystolithiasis 10.2 CCK TGFB1
18 nonalcoholic steatohepatitis 10.2 F2 GPT
19 ischemic neuropathy 10.2 CRP F2
20 blue toe syndrome 10.2 CRP F2
21 degos 'en cocarde' erythrokeratoderma 10.2
22 giant hemangioma 10.2 F2 TGFB1
23 antipyrine metabolism 10.2 ALB F2
24 non-a-e hepatitis 10.2 ALB F2
25 bone fracture 10.1 CRP TGFB1
26 epstein-barr virus hepatitis 10.1 ALB F2
27 fournier gangrene 10.1 ALB F2
28 orthostatic proteinuria 10.1 ALB C3
29 intussusception 10.1
30 peripheral vertigo 10.1 CRP F2
31 lemierre's syndrome 10.1 C3 CRP
32 splenic disease 10.1 ALB F2
33 gastrointestinal tuberculosis 10.1 ALB CRP
34 diffuse scleroderma 10.1 TGFB1 TNFRSF25
35 pyuria 10.1 ALB CRP
36 esophageal varix 10.1 ALB F2
37 decubitus ulcer 10.0 ALB CRP
38 pancreatitis 10.0
39 afferent loop syndrome 10.0
40 fascioliasis 10.0 ALB GPT
41 hypersplenism 10.0 ALB F2
42 endocardium disease 10.0 CRP F2
43 kidney hypertrophy 10.0 ALB TGFB1
44 tuberculous peritonitis 10.0 ALB CRP
45 pericardium disease 10.0 ALB CRP
46 biliary tract disease 10.0 ALB CCK F2
47 autoimmune disease of musculoskeletal system 10.0 C3 CRP TNFRSF25
48 mononeuritis multiplex 10.0 CRP MPO
49 aortitis 10.0 CRP MPO
50 compartment syndrome 9.9 ALB F2

Graphical network of the top 20 diseases related to Ascending Cholangitis:



Diseases related to Ascending Cholangitis

Symptoms & Phenotypes for Ascending Cholangitis

MGI Mouse Phenotypes related to Ascending Cholangitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.7 ALB BSG C3 CCK CHRM3 TGFB1
2 homeostasis/metabolism MP:0005376 9.61 ALB C3 CCK CHRM3 CRP F2
3 muscle MP:0005369 9.1 ALB C3 CHRM3 MPO PRKD1 TGFB1

Drugs & Therapeutics for Ascending Cholangitis

Drugs for Ascending Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Neomycin Approved, Vet_approved Not Applicable 1404-04-2 8378
2 Anti-Infective Agents Not Applicable
3 Anti-Bacterial Agents Not Applicable
4 Acidophilus Not Applicable
5 Liver Extracts
6
Bilirubin 635-65-4, 69853-43-6 21252250 5280352

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Probiotics to Prevent Cholangitis in Children With Biliary Atresia After the Kasai Portoenterostomy Completed NCT00166868 Not Applicable Lactobacillus casei rhamnosus (Lcr35);Neomycin
2 Intestinal Microbiome Composition in Infants With Biliary Atresia (BA) Not yet recruiting NCT03890536

Search NIH Clinical Center for Ascending Cholangitis

Genetic Tests for Ascending Cholangitis

Anatomical Context for Ascending Cholangitis

MalaCards organs/tissues related to Ascending Cholangitis:

42
Liver, Small Intestine, Kidney, Bone, Heart, Pancreas, Monocytes

Publications for Ascending Cholangitis

Articles related to Ascending Cholangitis:

(show top 50) (show all 51)
# Title Authors Year
1
"Primary bacterial culture of bile and pancreatic juice in tumor related jaundice (TROJ) - is ascending cholangitis always our fault?" ( 30621478 )
2019
2
Self-expanding metal stent procedure for afferent loop syndrome with ascending cholangitis caused by remnant gastric cancer: A case report. ( 30557964 )
2018
3
Mucinous cystic neoplasm of the liver with extrahepatic growth presenting with ascending cholangitis diagnosed by endoscopic ultrasound features: a case report. ( 29444709 )
2018
4
Abnormal presentation of ascending cholangitis. ( 29881588 )
2018
5
Unexpected cause of severe ascending cholangitis in a patient with chronic calculous cholecystitis. ( 30150354 )
2018
6
Stone-Induced Purulent Choledocoduodenal Fistula Presenting with Ascending Cholangitis. ( 30214909 )
2018
7
Ascending cholangitis: rare presentation of a ruptured right-sided renal angiomyolipoma. ( 29026516 )
2017
8
Ascending Cholangitis secondary to migrated embolization coil of gastroduodenal artery pseudo-aneurysm a case report. ( 28330448 )
2017
9
Ascending Cholangitis due to Heavy Lifting. ( 29033769 )
2017
10
Double pigtail for preventing ascending cholangitis after endoscopic ultrasonography-guided choledochoduodenostomy with lumen-apposing metal stent. ( 26354292 )
2016
11
A unique case of ascending cholangitis. ( 27157828 )
2016
12
Recurrent ascending cholangitis due to small intestinal bacterial overgrowth, gastrointestinal dysmotility and an afferent loop. ( 28839739 )
2013
13
Does the urgency of endoscopic retrograde cholangiopancreatography (ercp)/percutaneous biliary drainage (pbd) impact mortality and disease related complications in ascending cholangitis? (deim-i study). ( 23687602 )
2012
14
Endoscopic management of afferent loop syndrome after a pylorus preserving pancreatoduodenecotomy presenting with obstructive jaundice and ascending cholangitis. ( 22741115 )
2011
15
Endoscopic treatment of acute ascending cholangitis in a patient with Roux-en-Y limb obstruction after a Whipple operation. ( 21170836 )
2010
16
Ascending cholangitis presenting with Lactococcus lactis cremoris bacteraemia: a case report. ( 19126198 )
2009
17
Choledocholithiasis, ascending cholangitis, and gallstone pancreatitis. ( 18570948 )
2008
18
Toxic hepatic injury mimicking ascending cholangitis: is Pyrus amygdaliformis to blame? ( 18787839 )
2008
19
Management of ascending cholangitis. ( 17556149 )
2007
20
New strategy to prevent ascending cholangitis in larger choledochoduodenal fistula. ( 16922901 )
2006
21
Acute ascending cholangitis. ( 15108417 )
2004
22
Ascending cholangitis provokes IL-8 and MCP-1 expression and promotes inflammatory cell infiltration in the cholestatic rat liver. ( 11685687 )
2001
23
Ascending cholangitis as a cause of pyogenic liver abscesses complicated by a gastric submucosal abscess and fistula. ( 10777197 )
2000
24
Enterococcus hirae enteropathy with ascending cholangitis and pancreatitis in a kitten. ( 10810996 )
2000
25
Acute (ascending) cholangitis. ( 10987108 )
2000
26
An impacted metallic clip at the ampulla causing ascending cholangitis. ( 9165332 )
1997
27
Further experience with the antireflux valve to prevent ascending cholangitis in biliary atresia. ( 9349766 )
1997
28
Volvulus of the Roux-en-Y hepaticojejunostomy. A rare complication manifested by recurrent ascending cholangitis. ( 7928157 )
1994
29
Effectiveness of an intussusceptive antireflux valve to prevent ascending cholangitis after hepatic portojejunostomy in biliary atresia. ( 1895188 )
1991
30
The role of endoscopic papillotomy in ascending cholangitis. ( 2053744 )
1991
31
Mucosal intussusception to avoid ascending cholangitis. ( 2207590 )
1990
32
Ascending cholangitis: surgery versus endoscopic or percutaneous drainage. ( 2218872 )
1990
33
Intussusception-type antireflux valve in the Roux-en-Y loop to prevent ascending cholangitis after hepatic portojejunostomy. ( 2313499 )
1990
34
Problems involved in re-laparotomy for congenital biliary atresia: with special reference to postoperative ascending cholangitis. ( 3388986 )
1988
35
The benefit of emergency nasobiliary drain in cholelithiasis with ascending cholangitis, coagulopathy, and thrombocytopenia. ( 3726751 )
1986
36
The valved conduit prevents ascending cholangitis: a follow-up. ( 4087101 )
1985
37
Clinical and experimental studies on ascending cholangitis after Kasai's portoenterostomy for type III congenital bile duct atresia. ( 6511476 )
1984
38
Roux-en-Y on-line intussusception to avoid ascending cholangitis in biliary atresia. ( 6615221 )
1983
39
Cholelithiasis, ascending cholangitis and septicaemia. Report of a case in an 89-year-old woman. ( 6752931 )
1982
40
Ascending cholangitis secondary to a chicken bone lodged at the ampulla of Vater. ( 7013517 )
1981
41
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: measures for control. ( 741763 )
1978
42
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: measures and control. Invited commentary. ( 741764 )
1978
43
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: Measures and control. Invited commentary. ( 741784 )
1978
44
Ascending cholangitis diagnosed by percutaneous hepatic aspiration. ( 1107502 )
1976
45
Ascending cholangitis after successful surgical repair of biliary atresia. ( 4200280 )
1973
46
Ascending cholangitis: an urgent surgical problem. ( 4691603 )
1973
47
The management of ascending cholangitis. 1. Bacteriology and choice of antibiotic. ( 5768332 )
1969
48
The management of ascending cholangitis. II. Practical management and timing of operation. ( 5768333 )
1969
49
Ascending cholangitis. ( 5219417 )
1966
50
Grave ascending cholangitis following cholangiography carried out through the cystic duct infected with E. coli. ( 20990634 )
1946

Variations for Ascending Cholangitis

Expression for Ascending Cholangitis

Search GEO for disease gene expression data for Ascending Cholangitis.

Pathways for Ascending Cholangitis

Pathways related to Ascending Cholangitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.58 BSG F2 TGFB1
2
Show member pathways
11.26 ALB CRP F2 MPO
3 10.19 BSG TGFB1

GO Terms for Ascending Cholangitis

Cellular components related to Ascending Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 ALB C3 CCK CRP F2 MPO
2 axon GO:0030424 9.56 BSG CCK HPCA TGFB1
3 blood microparticle GO:0072562 9.26 ALB C3 F2 TGFB1
4 extracellular space GO:0005615 9.23 ALB C3 CCK CRP F2 GPT

Biological processes related to Ascending Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.54 C3 F2 TGFB1
2 positive regulation of protein import into nucleus GO:0042307 9.43 PRKD1 TGFB1
3 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.4 PRKD1 TGFB1
4 positive regulation of vascular endothelial growth factor production GO:0010575 9.32 C3 TGFB1
5 positive regulation of collagen biosynthetic process GO:0032967 9.26 F2 TGFB1
6 inflammatory response GO:0006954 9.26 C3 CRP PRKD1 TGFB1
7 positive regulation of protein localization to nucleus GO:1900182 9.16 F2 TGFB1
8 positive regulation of superoxide anion generation GO:0032930 8.62 CRP TGFB1

Molecular functions related to Ascending Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.02 ALB CRP HPCA PRKD1 TGFB1

Sources for Ascending Cholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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