MCID: ASC004
MIFTS: 31

Ascending Colon Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Ascending Colon Cancer

MalaCards integrated aliases for Ascending Colon Cancer:

Name: Ascending Colon Cancer 12 15
Malignant Tumor of Ascending Colon 12 6
Malignant Neoplasm of Ascending Colon 74
Malignant Neoplasm of Right Colon 12
Ca Ascending Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:218
ICD9CM 36 153.6
SNOMED-CT 69 93683002
ICD10 34 C18.2
UMLS 74 C0153439

Summaries for Ascending Colon Cancer

MalaCards based summary : Ascending Colon Cancer, also known as malignant tumor of ascending colon, is related to colorectal cancer and colitis. An important gene associated with Ascending Colon Cancer is MSH2 (MutS Homolog 2), and among its related pathways/superpathways are Integrated Breast Cancer Pathway and Autophagy - animal. The drugs Loperamide and Cola have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and lymph node, and related phenotype is homeostasis/metabolism.

Related Diseases for Ascending Colon Cancer

Graphical network of the top 20 diseases related to Ascending Colon Cancer:



Diseases related to Ascending Colon Cancer

Symptoms & Phenotypes for Ascending Colon Cancer

MGI Mouse Phenotypes related to Ascending Colon Cancer:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.1 KDM5B KRAS MSH2 POR UPK3A UVRAG

Drugs & Therapeutics for Ascending Colon Cancer

Drugs for Ascending Colon Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loperamide Approved Not Applicable 53179-11-6 3955
2 Cola Not Applicable
3 Gastrointestinal Agents Not Applicable
4 Antidiarrheals Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 ISOperistaltic Versus ANTIperistaltic Anastomosis After Laparoscopic Right Colectomy for Cancer Unknown status NCT02309931 Not Applicable
2 A Study of Laparoscopic Right Hemicolectomy Using the Caudal-to-cranial Approach Recruiting NCT02949440 Not Applicable

Search NIH Clinical Center for Ascending Colon Cancer

Genetic Tests for Ascending Colon Cancer

Anatomical Context for Ascending Colon Cancer

MalaCards organs/tissues related to Ascending Colon Cancer:

42
Colon, Liver, Lymph Node, Small Intestine

Publications for Ascending Colon Cancer

Articles related to Ascending Colon Cancer:

(show all 34)
# Title Authors Year
1
Ascending Colon Cancer with Pathologically Confirmed Tumor Thrombosis of Superior Mesenteric Vein: A Case Report. ( 30992420 )
2019
2
Peritoneal dissemination of ascending colon cancer demonstrating relapse-free survival for 40 months with panitumumab monotherapy: A case report. ( 31103951 )
2019
3
Case of laparoscopic right hemicolectomy for ascending colon cancer after aortic graft replacement and revascularization of the superior mesenteric artery. ( 29322641 )
2018
4
Improvement of anaphylactoid purpura in a patient with ascending colon cancer after colectomy. ( 30117628 )
2018
5
A case of ascending colon cancer accompanied with tumor thrombosis in the superior mesenteric vein treated with right hemicolectomy and greater saphenous vein grafting. ( 30261478 )
2018
6
Ascending colon cancer with synchronous external iliac and inguinal lymph node metastases but without regional lymph node metastasis: a case report and brief literature review. ( 28220469 )
2017
7
Ileal perforation following cetuximab and FOLFIRI chemotherapy in a patient with ascending colon cancer with peritoneal carcinomatosis. ( 28730797 )
2017
8
Necrotizing soft tissue infection of the thigh associated with retroperitoneal abscess in a patient with locally advanced ascending colon cancer: A case report. ( 29124012 )
2017
9
Metachronous mediastinal lymph node metastasis from ascending colon cancer: A case report and literature review. ( 29145106 )
2017
10
Ascending Colon Cancer Associated with Dermatomyositis Which Was Cured after Colon Resection. ( 27482193 )
2016
11
Ascending colon cancer associated with deposited ova of Schistosoma japonicum in non-endemic area. ( 27713858 )
2016
12
[Synchronous Double Cancer Involving Gastric Cancer Resembling a Submucosal Tumor with Stenosis in the Pylorus and Ascending Colon Cancer - A Case Report]. ( 28133166 )
2016
13
Laparoscopic right hemicolectomy for metachronous ascending colon cancer with preservation of an ileal conduit constructed after previous radical cystectomy for bladder cancer. ( 25913585 )
2015
14
[Tumor lysis syndrome after FOLFIRI+cetuximab for ascending colon cancer]. ( 25843460 )
2015
15
Missed ascending colon cancer in an older patient with extensive ulcerative colitis. ( 24623546 )
2014
16
Laparoscopic right hemicolectomy for ascending colon cancer with persistent mesocolon. ( 24833887 )
2014
17
Laparoscopic surgery for the ascending colon cancer associated with malrotation of the midgut. ( 24426518 )
2013
18
Ischaemic colitis mimicking ascending colon cancer. ( 22697158 )
2012
19
Good response to leucovorin and fluorouracil plus oxaliplatin and cetuximab therapy in a patient with metastatic ascending colon cancer harboring a KRAS p.G13D mutation. ( 22740893 )
2012
20
Perforated ascending colon cancer presenting as colocutaneous fistula with abscess to the anterior abdominal wall at the site of a cholecystectomy scar treated with biologic mesh. ( 22816243 )
2012
21
Successful combination therapy of radical liver resection with 5-fluorouracil/leucovorin, oxaliplatin, plus bevacizumab for ascending colon cancer with pulmonary and 43 liver metastases: report of a case. ( 23101994 )
2012
22
Mesothelial mesenteric cyst in patient with ascending colon cancer. Case report. ( 21453591 )
2011
23
Laparoscopy-assisted resection of an undiagnosed liver tumor and ascending colon cancer via mini median laparotomy: report of a case. ( 21969197 )
2011
24
Granulocyte colony-stimulating factor-producing ascending colon cancer as indicated by histopathological findings: report of a case. ( 22443081 )
2011
25
Cecal perforation with an ascending colon cancer caused by upper gastrointestinal endoscopy. ( 19536313 )
2009
26
Abscess of the abdominal wall resulting from perforated ascending colon cancer. ( 20084789 )
2009
27
Recurrent Ascending Colon Cancer Manifesting as Inferior Vena cava Thrombus. ( 21327176 )
2008
28
Ascending colon cancer in a patient with situs inversus. ( 17879697 )
2007
29
Left paraduodenal hernia in an adult complicated by ascending colon cancer: a case report. ( 16586557 )
2006
30
Abdominal wall and thigh abscess resulting from the penetration of ascending colon cancer. ( 16418772 )
2005
31
Spontaneously significant pneumoretroperitoneum misinterpreted as herniated intervertebral disc: an unusual presentation of perforation of ascending colon cancer. ( 15481328 )
2004
32
Ascending colon cancer with hepatic metastasis and cholecystolithiasis in a patient with situs inversus totalis without any expression of UVRAG mRNA: report of a case. ( 12928850 )
2003
33
Rapid growth of a retroperitoneal rhabdomyosarcoma following right hemicolectomy for ascending colon cancer: report of a case. ( 10795872 )
2000
34
Relationship between cholecystectomy and ascending colon cancer. ( 7351021 )
1980

Variations for Ascending Colon Cancer

ClinVar genetic disease variations for Ascending Colon Cancer:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 MSH2 NM_000251.2(MSH2): c.2038C> T (p.Arg680Ter) single nucleotide variant Pathogenic rs63749932 GRCh37 Chromosome 2, 47703538: 47703538
2 MSH2 NM_000251.2(MSH2): c.2038C> T (p.Arg680Ter) single nucleotide variant Pathogenic rs63749932 GRCh38 Chromosome 2, 47476399: 47476399
3 APC NM_000038.5(APC): c.6553A> G (p.Ser2185Gly) single nucleotide variant Uncertain significance rs1060503292 GRCh37 Chromosome 5, 112177844: 112177844
4 APC NM_000038.5(APC): c.6553A> G (p.Ser2185Gly) single nucleotide variant Uncertain significance rs1060503292 GRCh38 Chromosome 5, 112842147: 112842147

Expression for Ascending Colon Cancer

Search GEO for disease gene expression data for Ascending Colon Cancer.

Pathways for Ascending Colon Cancer

Pathways related to Ascending Colon Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.44 KRAS MSH2
2 11.26 KRAS UVRAG
3 10.82 KRAS UPK3A
4
Show member pathways
10.23 MSH2 POR

GO Terms for Ascending Colon Cancer

Biological processes related to Ascending Colon Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 8.62 KRAS MSH2

Sources for Ascending Colon Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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