MCID: ASC004
MIFTS: 42

Ascending Colon Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Ascending Colon Cancer

MalaCards integrated aliases for Ascending Colon Cancer:

Name: Ascending Colon Cancer 12 15
Malignant Tumor of Ascending Colon 12 6
Malignant Neoplasm of Ascending Colon 70
Malignant Neoplasm of Right Colon 12
Ca Ascending Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:218
ICD9CM 34 153.6
SNOMED-CT 67 93683002
ICD10 32 C18.2
UMLS 70 C0153439

Summaries for Ascending Colon Cancer

MalaCards based summary : Ascending Colon Cancer, also known as malignant tumor of ascending colon, is related to cholecystolithiasis and exanthem. An important gene associated with Ascending Colon Cancer is MSH2 (MutS Homolog 2), and among its related pathways/superpathways are Pathways in cancer and Endometrial cancer. The drugs Loperamide and Antidiarrheals have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and appendix, and related phenotypes are digestive/alimentary and neoplasm

Related Diseases for Ascending Colon Cancer

Diseases related to Ascending Colon Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 244)
# Related Disease Score Top Affiliating Genes
1 cholecystolithiasis 30.2 UVRAG CEACAM5
2 exanthem 30.2 KRAS HRAS CSF3
3 lynch syndrome 29.6 MSH2 MLH1 KRAS HRAS
4 appendix adenocarcinoma 29.5 KRAS HRAS CDX2
5 microinvasive gastric cancer 29.4 MLH1 CEACAM5 CDX2
6 familial adenomatous polyposis 29.4 MSH2 MLH1 KRAS HRAS
7 neurofibromatosis 29.4 MSH2 MLH1 KRAS HRAS
8 cholangiocarcinoma 29.4 KRAS CEACAM5 CDX2
9 rhabdomyosarcoma 29.2 MSH2 MLH1 KRAS HRAS
10 cecum carcinoma 29.1 MSH2 MLH1 KRAS HRAS CEACAM5
11 mucinous adenocarcinoma 29.1 MLH1 KRAS CEACAM5 CDX2
12 rectum cancer 29.1 RAB11B MSH2 MLH1 KRAS HRAS CEACAM5
13 lymphangioma 28.7 MLH1 KRAS HRAS CEACAM5 CDX2
14 gastric cancer 28.4 MSH2 MLH1 KRAS HRAS CEACAM5 CDX2
15 tubular adenocarcinoma 10.4
16 ileus 10.2
17 mature teratoma 10.2 KRAS CEACAM5
18 pancreatic cystadenocarcinoma 10.2 KRAS CEACAM5
19 urachal adenocarcinoma 10.2 KRAS CEACAM5
20 rectosigmoid junction neoplasm 10.2 KRAS CEACAM5
21 bile acid synthesis defect, congenital, 5 10.2 KRAS CEACAM5
22 colorectal cancer 10.2
23 colitis 10.2
24 thrombosis 10.2
25 hepatic flexure cancer 10.2 KRAS HRAS
26 trachea carcinoma in situ 10.2 KRAS HRAS
27 cobblestone retinal degeneration 10.2 KRAS HRAS
28 pancreatic signet ring cell adenocarcinoma 10.2 KRAS HRAS
29 ampulla of vater benign neoplasm 10.2 KRAS HRAS
30 periampullary adenoma 10.2 KRAS HRAS
31 bone giant cell sarcoma 10.2 KRAS HRAS
32 acneiform dermatitis 10.2 KRAS HRAS
33 gallbladder benign neoplasm 10.2 KRAS HRAS
34 adenosquamous lung carcinoma 10.2 KRAS HRAS
35 mucinous lung adenocarcinoma 10.1 KRAS HRAS
36 wolffian duct adenocarcinoma 10.1 KRAS HRAS
37 noonan syndrome-like disorder with loose anagen hair 1 10.1 KRAS HRAS
38 noonan syndrome-like disorder with loose anagen hair 10.1 KRAS HRAS
39 pancreatic acinar cell adenocarcinoma 10.1 KRAS HRAS
40 extrahepatic bile duct adenoma 10.1 MSH2 MLH1
41 paronychia 10.1 KRAS HRAS
42 renal pelvis transitional cell carcinoma 10.1 MSH2 MLH1
43 ovarian benign neoplasm 10.1 HRAS CEACAM5
44 colorectal cancer 2 10.1 MSH2 MLH1
45 lung carcinoma in situ 10.1 KRAS HRAS
46 autosomal dominant non-syndromic intellectual disability 8 10.1 MSH2 MLH1
47 appendix carcinoid tumor 10.1 MSH2 MLH1
48 pulmonary adenocarcinoma in situ 10.1 KRAS HRAS
49 oculoectodermal syndrome 10.1 KRAS HRAS
50 large intestine adenocarcinoma 10.1 KRAS HRAS

Comorbidity relations with Ascending Colon Cancer via Phenotypic Disease Network (PDN): (show all 11)


Active Peptic Ulcer Disease Cecal Benign Neoplasm
Colon Carcinoma in Situ Colorectal Cancer
Deficiency Anemia Hepatic Flexure Cancer
Intestinal Obstruction Iron Deficiency Anemia
Paralytic Ileus Rectosigmoid Junction Neoplasm
Transverse Colon Cancer

Graphical network of the top 20 diseases related to Ascending Colon Cancer:



Diseases related to Ascending Colon Cancer

Symptoms & Phenotypes for Ascending Colon Cancer

MGI Mouse Phenotypes related to Ascending Colon Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.43 CDX2 HRAS KRAS MLH1 MSH2 SPDEF
2 neoplasm MP:0002006 9.02 CDX2 HRAS KRAS MLH1 MSH2

Drugs & Therapeutics for Ascending Colon Cancer

Drugs for Ascending Colon Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loperamide Approved 53179-11-6 3955
2 Antidiarrheals
3 Gastrointestinal Agents
4 Cola

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Clinical Trial Comparing Isoperistaltic Versus Antiperistaltic Side to Side Anastomosis After Right Laparoscopic Hemicolectomy for Cancer. Unknown status NCT02309931
2 A Prospective Randomized Controlled Clinical Study of Laparoscopic Right Hemicolectomy Using the Caudal-to-cranial Approach Recruiting NCT02949440

Search NIH Clinical Center for Ascending Colon Cancer

Genetic Tests for Ascending Colon Cancer

Anatomical Context for Ascending Colon Cancer

MalaCards organs/tissues related to Ascending Colon Cancer:

40
Colon, Liver, Appendix, Lung, Lymph Node, Ovary, Small Intestine

Publications for Ascending Colon Cancer

Articles related to Ascending Colon Cancer:

(show top 50) (show all 318)
# Title Authors PMID Year
1
Anomalous origin of the middle colic artery from the ileocecal artery affecting laparoscopic ascending colon cancer resection. 61
33717389 2021
2
Propensity score-matched comparison between totally laparoscopic right hemicolectomy with transcolonic natural orifice specimen extraction and conventional laparoscopic surgery with mini-laparotomy in the treatment of ascending colon cancer (with video). 61
33798538 2021
3
Anti-transcription intermediary factor 1 gamma (TIF1γ) antibody-positive dermatomyositis associated with ascending colon cancer: a case report and review of the literature. 61
33745453 2021
4
Metachronous ileal cancer after surgery for ascending colon cancer in a patient with Lynch syndrome: A case report. 61
33684646 2021
5
[Successful Experience of Negative Pressure Wound Therapy with Instillation and Dwelling(NPW Ti-d)for Patient with Wound Dehiscence Developed by Infection after Right-Hemicolectomy for Ascending Colon Cancer]. 61
33597380 2021
6
[A Case of Metastatic and Recurrent Colon Cancer Whose QOL Kept Longly by Multidisciplinary Treatment Including Six Times Surgical Operation]. 61
33468745 2021
7
Colorectal Cancer with EML4-ALK Fusion Gene Response to Alectinib: A Case Report and Review of the Literature. 61
33776709 2021
8
Quadruple gastrointestinal cancer with discordance of mismatch repair protein deficiency and microsatellite instability suggesting Lynch syndrome. 61
33489692 2021
9
An aberrant mediastinal medial basal segmental pulmonary artery (A7a) in a patient with lung cancer: a case report. 61
33439353 2021
10
[A Case of Metastatic Colorectal Cancer with Hyperammonemic Encephalopathy Induced by mFOLFOX6 and SOX Therapy]. 61
33468827 2020
11
[Ascending Colon Cancer with Hemophilia A Treated with Laparoscopic Right Hemicolectomy under Control of a Blood Coagulant Factor-A Case Report]. 61
33468918 2020
12
[A Case of Granulocyte-Colony Stimulating Factor Producing Ascending Colon Cancer]. 61
33468832 2020
13
[Hemorrhage of Peritoneal Dissemination of the Ascending Colon Cancer Successfully Controlled by Palliative Radiotherapy-A Case Report]. 61
33468767 2020
14
[A Case of Ascending Colon Cancer with Essential Thrombocythemia]. 61
33468948 2020
15
[A Case of Advanced and Recurrent Colon Cancer with Long-Term Survival after Seven Repeated Surgical Resections]. 61
33468844 2020
16
[Resection of Synchronous Liver Metastasis from Ascending Colon Cancer with Aplastic Anemia-A Case Report]. 61
33468879 2020
17
Scirrhous colon cancer presenting as a pseudokidney sign. 61
33363979 2020
18
A young woman who developed ascending colon cancer 2 years after the onset of ulcerative colitis. 61
32780275 2020
19
Laparoscopic right hemicolectomy for an ascending colon cancer patient with an implantable left ventricular assist device: a case report. 61
33165746 2020
20
Pure transanal endoscopic colectomy for ascending colon cancer. 61
32583146 2020
21
Robotic Complete Mesocolic Excision After Neoadjuvant Chemotherapy for Advanced Ascending Colon Cancer. 61
32969891 2020
22
Utility of ICG fluorescence imaging with vessel clamp for ileocecal resection while preserving ileal conduit constructed after previous total cystectomy. 61
33006721 2020
23
TIPS to the rescue: Preoperative Transjugular Intrahepatic Portosystemic Shunt (TIPS) placement in a patient with caput medusae and colon cancer. 61
32642010 2020
24
[Metachronous Pubic Bone Metastases from Synchronous Double Cancer with Prostate and Ascending Colon Cancers : A Case Report]. 61
32882125 2020
25
Intestinal tuberculosis in a patient with end-stage renal disease on hemodialysis: A case report. 61
32769931 2020
26
Risk Factor Profiles Differ for Cancers of Different Regions of the Colorectum. 61
32247020 2020
27
Proposal of a Classification System for Adenocarcinoma Involving the Ileocecal Valve (Bauhin's Valve): A Retrospective Study of 689 Right Hemicolectomized Patients. 61
32620652 2020
28
Multiple peritoneal dissemination of T2 colorectal cancer without lymph node metastases: a case report. 61
32760481 2020
29
Ascending colon cancer with synchronous right external iliac lymph node metastasis. 61
32582524 2020
30
[A Case of Severe Aortic Thrombosis during the First Chemotherapy Regimen of CapeOX plus Bevacizumab for Metastatic Colon Cancer]. 61
32541181 2020
31
Metachronous Mesorectal Recurrence after Colectomy for Ascending Colon Cancer. 61
32774249 2020
32
Cutaneous metastasis of ascending colon cancer harboring a BRAF V600E mutation: A rare case report. 61
32481270 2020
33
Intramural metastasis to the appendix from ascending colon cancer: a case report. 61
32277313 2020
34
Correction to: Intramural metastasis to the appendix from ascending colon cancer: a case report. 61
32314146 2020
35
[A Case of Intussusception Caused by Ascending Colon Cancer in an Elderly Woman]. 61
32389972 2020
36
[A Case of Laparoscopic Ileocecal Resection for Ascending Colon Cancer with Portosystemic Shunt]. 61
32381940 2020
37
A two-step surgery and a multidisciplinary approach in a centenarian patient with an acute presentation of right colon cancer. 61
32188448 2020
38
[A Case of Ascending Colon Cancer with Synchronous Unresectable Liver Metastasis Maintaining a Long-Term Stable Disease State after Discontinuing Chemotherapy]. 61
32381962 2020
39
[A Case of Colon Cancer with Peritoneal Dissemination and Liver Metastasis That Responded to Comprehensive Treatment by Perioperative Chemotherapy and Cytoreductive Surgery]. 61
32381992 2020
40
[A Case of Unresectable Ascending Colon Cancer Treated with a Newly Devised Bypass Method]. 61
32381991 2020
41
[A Case of Complete Pathological Response in a Patient with Advanced Ascending Colon Cancer That Invaded the Liver and Duodenum after FOLFOXIRI plus Bevacizumab Chemotherapy]. 61
32381968 2020
42
Ascending colon cancer accompanied by tumor thrombosis in the superior mesenteric vein: A case report. 61
32721884 2020
43
[Tumor Embolisms from Colon Cancer Detected on Transcatheter Examination-A Case Report]. 61
32381884 2020
44
Subtotal gastrectomy for gastric tube cancer using intraoperative indocyanine green fluorescence method. 61
32480340 2020
45
A Rare Case of Moderately Differentiated Adenocarcinoma With PD-L1 Overexpression and a Heterogeneous LELC Component in the Ascending Colon. 61
32095077 2020
46
[A Case Report on Larynx-Preserving Surgery with Tracheal Resection of an Advanced Esophageal Cancer with Tracheal Invasion]. 61
32156988 2019
47
[A Case of Histological Complete Remission after Chemotherapy for Paraaortic Lymph Node Recurrence after Colon Cancer Surgery]. 61
32156982 2019
48
[Successful Treatment of Necrotizing Fasciitis Due to Ascending Colon Cancer-A Case Report]. 61
32157003 2019
49
Case report of ascending colon cancer and multiple jejunal GISTs in a patient with neurofibromatosis type 1 (NF1). 61
31805970 2019
50
Improvement of anaphylactoid purpura in a patient with ascending colon cancer after colectomy. 61
30117628 2019

Variations for Ascending Colon Cancer

ClinVar genetic disease variations for Ascending Colon Cancer:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 MSH2 NM_000251.3(MSH2):c.2038C>T (p.Arg680Ter) SNV Pathogenic 36572 rs63749932 GRCh37: 2:47703538-47703538
GRCh38: 2:47476399-47476399
2 APC NM_000038.6(APC):c.6553A>G (p.Ser2185Gly) SNV Uncertain significance 411410 rs1060503292 GRCh37: 5:112177844-112177844
GRCh38: 5:112842147-112842147

Expression for Ascending Colon Cancer

Search GEO for disease gene expression data for Ascending Colon Cancer.

Pathways for Ascending Colon Cancer

Pathways related to Ascending Colon Cancer according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1 12.48 MSH2 MLH1 KRAS HRAS
2
Show member pathways
12.36 MSH2 MLH1 KRAS HRAS
3
Show member pathways
12.22 MLH1 KRAS HRAS CDX2
4
Show member pathways
11.94 KRAS HRAS CEACAM5
5
Show member pathways
11.85 MSH2 MLH1 KRAS HRAS
6 11.83 MSH2 MLH1 KRAS
7 11.47 UVRAG KRAS HRAS
8 11.09 KRAS HRAS
9 11.03 KRAS HRAS
10 11.02 KRAS HRAS
11 11 MSH2 MLH1
12
Show member pathways
10.99 KRAS HRAS
13 10.86 KRAS HRAS
14 10.82 KRAS HRAS
15 10.71 KRAS HRAS
17 9.74 KRAS HRAS

GO Terms for Ascending Colon Cancer

Cellular components related to Ascending Colon Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 8.62 MSH2 MLH1

Biological processes related to Ascending Colon Cancer according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.8 KRAS HRAS CSF3 CDX2
2 negative regulation of neuron apoptotic process GO:0043524 9.61 MSH2 KRAS HRAS
3 mismatch repair GO:0006298 9.51 MSH2 MLH1
4 positive regulation of actin cytoskeleton reorganization GO:2000251 9.48 HRAS CSF3
5 regulation of long-term neuronal synaptic plasticity GO:0048169 9.46 KRAS HRAS
6 isotype switching GO:0045190 9.4 MSH2 MLH1
7 somatic hypermutation of immunoglobulin genes GO:0016446 9.37 MSH2 MLH1
8 positive regulation of isotype switching to IgG isotypes GO:0048304 9.32 MSH2 MLH1
9 response to isolation stress GO:0035900 9.26 KRAS HRAS
10 positive regulation of isotype switching to IgA isotypes GO:0048298 9.16 MSH2 MLH1
11 somatic recombination of immunoglobulin gene segments GO:0016447 8.96 MSH2 MLH1
12 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 8.62 MSH2 MLH1

Molecular functions related to Ascending Colon Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatched DNA binding GO:0030983 9.16 MSH2 MLH1
2 GDP binding GO:0019003 9.13 RAB11B KRAS HRAS
3 guanine/thymine mispair binding GO:0032137 8.62 MSH2 MLH1

Sources for Ascending Colon Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....