MCID: ASC004
MIFTS: 30

Ascending Colon Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Ascending Colon Cancer

MalaCards integrated aliases for Ascending Colon Cancer:

Name: Ascending Colon Cancer 12 15
Malignant Tumor of Ascending Colon 12 6
Malignant Neoplasm of Ascending Colon 73
Malignant Neoplasm of Right Colon 12
Ca Ascending Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:218
ICD10 33 C18.2
ICD9CM 35 153.6
SNOMED-CT 68 93683002
UMLS 73 C0153439

Summaries for Ascending Colon Cancer

MalaCards based summary : Ascending Colon Cancer, also known as malignant tumor of ascending colon, is related to colorectal cancer and colitis. An important gene associated with Ascending Colon Cancer is MSH2 (MutS Homolog 2), and among its related pathways/superpathways is Doxorubicin Pathway, Pharmacokinetics. The drugs Loperamide and Cola have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and lymph node, and related phenotypes are cellular and homeostasis/metabolism

Related Diseases for Ascending Colon Cancer

Graphical network of the top 20 diseases related to Ascending Colon Cancer:



Diseases related to Ascending Colon Cancer

Symptoms & Phenotypes for Ascending Colon Cancer

MGI Mouse Phenotypes related to Ascending Colon Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.35 MSH2 NODAL POR SMUG1 UVRAG
2 homeostasis/metabolism MP:0005376 9.1 MSH2 NODAL POR SMUG1 UPK3A UVRAG

Drugs & Therapeutics for Ascending Colon Cancer

Drugs for Ascending Colon Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loperamide Approved Not Applicable 53179-11-6 3955
2 Cola Not Applicable
3 Gastrointestinal Agents Not Applicable
4 Antidiarrheals Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study of Laparoscopic Right Hemicolectomy Using the Caudal-to-cranial Approach Recruiting NCT02949440 Not Applicable
2 ISOperistaltic Versus ANTIperistaltic Anastomosis After Laparoscopic Right Colectomy for Cancer Active, not recruiting NCT02309931 Not Applicable

Search NIH Clinical Center for Ascending Colon Cancer

Genetic Tests for Ascending Colon Cancer

Anatomical Context for Ascending Colon Cancer

MalaCards organs/tissues related to Ascending Colon Cancer:

41
Colon, Liver, Lymph Node

Publications for Ascending Colon Cancer

Articles related to Ascending Colon Cancer:

(show all 32)
# Title Authors Year
1
Case of laparoscopic right hemicolectomy for ascending colon cancer after aortic graft replacement and revascularization of the superior mesenteric artery. ( 29322641 )
2018
2
Improvement of anaphylactoid purpura in a patient with ascending colon cancer after colectomy. ( 30117628 )
2018
3
A case of ascending colon cancer accompanied with tumor thrombosis in the superior mesenteric vein treated with right hemicolectomy and greater saphenous vein grafting. ( 30261478 )
2018
4
Necrotizing soft tissue infection of the thigh associated with retroperitoneal abscess in a patient with locally advanced ascending colon cancer: A case report. ( 29124012 )
2017
5
Metachronous mediastinal lymph node metastasis from ascending colon cancer: A case report and literature review. ( 29145106 )
2017
6
Ascending colon cancer with synchronous external iliac and inguinal lymph node metastases but without regional lymph node metastasis: a case report and brief literature review. ( 28220469 )
2017
7
Ileal perforation following cetuximab and FOLFIRI chemotherapy in a patient with ascending colon cancer with peritoneal carcinomatosis. ( 28730797 )
2017
8
Ascending colon cancer associated with deposited ova of Schistosoma japonicum in non-endemic area. ( 27713858 )
2016
9
[Synchronous Double Cancer Involving Gastric Cancer Resembling a Submucosal Tumor with Stenosis in the Pylorus and Ascending Colon Cancer - A Case Report]. ( 28133166 )
2016
10
Ascending Colon Cancer Associated with Dermatomyositis Which Was Cured after Colon Resection. ( 27482193 )
2016
11
Tumor lysis syndrome after FOLFIRI+cetuximab for ascending colon cancer. ( 25843460 )
2015
12
Laparoscopic right hemicolectomy for metachronous ascending colon cancer with preservation of an ileal conduit constructed after previous radical cystectomy for bladder cancer. ( 25913585 )
2015
13
Missed ascending colon cancer in an older patient with extensive ulcerative colitis. ( 24623546 )
2014
14
Laparoscopic right hemicolectomy for ascending colon cancer with persistent mesocolon. ( 24833887 )
2014
15
Laparoscopic surgery for the ascending colon cancer associated with malrotation of the midgut. ( 24426518 )
2013
16
Successful combination therapy of radical liver resection with 5-fluorouracil/leucovorin, oxaliplatin, plus bevacizumab for ascending colon cancer with pulmonary and 43 liver metastases: report of a case. ( 23101994 )
2012
17
Good response to leucovorin and fluorouracil plus oxaliplatin and cetuximab therapy in a patient with metastatic ascending colon cancer harboring a KRAS p.G13D mutation. ( 22740893 )
2012
18
Perforated ascending colon cancer presenting as colocutaneous fistula with abscess to the anterior abdominal wall at the site of a cholecystectomy scar treated with biologic mesh. ( 22816243 )
2012
19
Ischaemic colitis mimicking ascending colon cancer. ( 22697158 )
2012
20
Mesothelial mesenteric cyst in patient with ascending colon cancer. Case report. ( 21453591 )
2011
21
Laparoscopy-assisted resection of an undiagnosed liver tumor and ascending colon cancer via mini median laparotomy: report of a case. ( 21969197 )
2011
22
Granulocyte colony-stimulating factor-producing ascending colon cancer as indicated by histopathological findings: report of a case. ( 22443081 )
2011
23
Abscess of the abdominal wall resulting from perforated ascending colon cancer. ( 20084789 )
2009
24
Cecal perforation with an ascending colon cancer caused by upper gastrointestinal endoscopy. ( 19536313 )
2009
25
Recurrent Ascending Colon Cancer Manifesting as Inferior Vena cava Thrombus. ( 21327176 )
2008
26
Ascending colon cancer in a patient with situs inversus. ( 17879697 )
2007
27
Left paraduodenal hernia in an adult complicated by ascending colon cancer: a case report. ( 16586557 )
2006
28
Abdominal wall and thigh abscess resulting from the penetration of ascending colon cancer. ( 16418772 )
2005
29
Spontaneously significant pneumoretroperitoneum misinterpreted as herniated intervertebral disc: an unusual presentation of perforation of ascending colon cancer. ( 15481328 )
2004
30
Ascending colon cancer with hepatic metastasis and cholecystolithiasis in a patient with situs inversus totalis without any expression of UVRAG mRNA: report of a case. ( 12928850 )
2003
31
Rapid growth of a retroperitoneal rhabdomyosarcoma following right hemicolectomy for ascending colon cancer: report of a case. ( 10795872 )
2000
32
Relationship between cholecystectomy and ascending colon cancer. ( 7351021 )
1980

Variations for Ascending Colon Cancer

ClinVar genetic disease variations for Ascending Colon Cancer:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 MSH2 NM_000251.2(MSH2): c.2038C> T (p.Arg680Ter) single nucleotide variant Pathogenic rs63749932 GRCh37 Chromosome 2, 47703538: 47703538
2 MSH2 NM_000251.2(MSH2): c.2038C> T (p.Arg680Ter) single nucleotide variant Pathogenic rs63749932 GRCh38 Chromosome 2, 47476399: 47476399
3 APC NM_000038.5(APC): c.6553A> G (p.Ser2185Gly) single nucleotide variant Uncertain significance rs1060503292 GRCh37 Chromosome 5, 112177844: 112177844
4 APC NM_000038.5(APC): c.6553A> G (p.Ser2185Gly) single nucleotide variant Uncertain significance rs1060503292 GRCh38 Chromosome 5, 112842147: 112842147

Expression for Ascending Colon Cancer

Search GEO for disease gene expression data for Ascending Colon Cancer.

Pathways for Ascending Colon Cancer

Pathways related to Ascending Colon Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.23 MSH2 POR

GO Terms for Ascending Colon Cancer

Biological processes related to Ascending Colon Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.13 MSH2 SMUG1 UVRAG
2 DNA repair GO:0006281 8.8 MSH2 SMUG1 UVRAG

Sources for Ascending Colon Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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