MCID: ASC004
MIFTS: 42

Ascending Colon Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Ascending Colon Cancer

MalaCards integrated aliases for Ascending Colon Cancer:

Name: Ascending Colon Cancer 12 15
Malignant Tumor of Ascending Colon 12 6
Malignant Neoplasm of Ascending Colon 71
Malignant Neoplasm of Right Colon 12
Ca Ascending Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:218
ICD9CM 34 153.6
SNOMED-CT 67 93683002
ICD10 32 C18.2
UMLS 71 C0153439

Summaries for Ascending Colon Cancer

MalaCards based summary : Ascending Colon Cancer, also known as malignant tumor of ascending colon, is related to cholecystolithiasis and exanthem. An important gene associated with Ascending Colon Cancer is MSH2 (MutS Homolog 2), and among its related pathways/superpathways are TCR Signaling (Qiagen) and Endometrial cancer. The drugs Cola and Loperamide have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and ovary, and related phenotypes are digestive/alimentary and neoplasm

Related Diseases for Ascending Colon Cancer

Diseases related to Ascending Colon Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 224)
# Related Disease Score Top Affiliating Genes
1 cholecystolithiasis 30.3 UVRAG CEACAM5
2 exanthem 29.7 KRAS HRAS CSF3
3 cholangiocarcinoma 29.3 KRAS CEACAM5 CDX2
4 intestinal obstruction 29.2 CEACAM5 CDX2 APOLD1
5 microinvasive gastric cancer 29.1 MLH1 CEACAM5 CDX2
6 lynch syndrome 29.0 MSH2 MLH1 KRAS HRAS
7 appendix adenocarcinoma 28.8 KRAS HRAS CEACAM5 CDX2
8 mucinous adenocarcinoma 28.7 MLH1 KRAS CEACAM5 CDX2
9 cecum carcinoma 28.6 MSH2 MLH1 KRAS HRAS CEACAM5
10 rectum cancer 28.2 MSH2 MLH1 KRAS HRAS CEACAM5 APOLD1
11 colorectal cancer 10.8
12 tubular adenocarcinoma 10.3
13 urachal adenocarcinoma 10.3 KRAS CEACAM5
14 immature teratoma of ovary 10.3 KRAS CEACAM5
15 mature teratoma 10.3 KRAS CEACAM5
16 apocrine adenoma 10.3 KRAS CEACAM5
17 ovarian clear cell cystadenocarcinoma 10.3 CSF3 APOLD1
18 ovarian clear cell malignant adenofibroma 10.3 CSF3 APOLD1
19 mixed epithelial tumor of ovary 10.2 CSF3 APOLD1
20 fallopian tube transitional cell carcinoma 10.2 CSF3 APOLD1
21 fallopian tube mucinous adenocarcinoma 10.2 CSF3 APOLD1
22 colon leiomyosarcoma 10.2 CEACAM5 APOLD1
23 papillary adenoma 10.2 KRAS HRAS
24 rectosigmoid junction neoplasm 10.2 CEACAM5 APOLD1
25 sigmoid neoplasm 10.2 CEACAM5 APOLD1
26 trachea carcinoma in situ 10.2 KRAS HRAS
27 ileus 10.2
28 ovarian benign neoplasm 10.2 KRAS CEACAM5
29 ectomesenchymoma 10.2 MSH2 HRAS
30 hepatic flexure cancer 10.2 KRAS APOLD1
31 adult teratoma 10.2 HRAS CEACAM5
32 ampulla of vater neoplasm 10.2 KRAS HRAS
33 periampullary adenoma 10.2 KRAS HRAS
34 acneiform dermatitis 10.1 KRAS HRAS
35 renal pelvis transitional cell carcinoma 10.1 MSH2 MLH1
36 extrahepatic bile duct adenoma 10.1 MSH2 MLH1
37 appendix carcinoid tumor 10.1 MSH2 MLH1
38 mucinous lung adenocarcinoma 10.1 KRAS HRAS
39 wolffian duct adenocarcinoma 10.1 KRAS HRAS
40 cervical adenoma malignum 10.1 MSH2 MLH1
41 schimmelpenning-feuerstein-mims syndrome 10.1 KRAS HRAS
42 pancreatic acinar cell adenocarcinoma 10.1 KRAS HRAS
43 ovarian squamous cell carcinoma 10.1 CEACAM5 APOLD1
44 autosomal dominant non-syndromic intellectual disability 8 10.1 MSH2 MLH1
45 colorectal cancer, hereditary nonpolyposis, type 6 10.1 MSH2 MLH1
46 in situ pulmonary adenocarcinoma 10.1 KRAS HRAS
47 lower lip cancer 10.1 MSH2 MLH1
48 paronychia 10.1 KRAS HRAS
49 sebaceous adenoma 10.1 MSH2 MLH1
50 large intestine lipoma 10.1 CEACAM5 APOLD1

Comorbidity relations with Ascending Colon Cancer via Phenotypic Disease Network (PDN): (show all 11)


Active Peptic Ulcer Disease Cecal Benign Neoplasm
Colon Carcinoma in Situ Colorectal Cancer
Deficiency Anemia Hepatic Flexure Cancer
Intestinal Obstruction Iron Deficiency Anemia
Paralytic Ileus Rectosigmoid Junction Neoplasm
Transverse Colon Cancer

Graphical network of the top 20 diseases related to Ascending Colon Cancer:



Diseases related to Ascending Colon Cancer

Symptoms & Phenotypes for Ascending Colon Cancer

MGI Mouse Phenotypes related to Ascending Colon Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.43 CDX2 HRAS KRAS MLH1 MSH2 SPDEF
2 neoplasm MP:0002006 9.02 CDX2 HRAS KRAS MLH1 MSH2

Drugs & Therapeutics for Ascending Colon Cancer

Drugs for Ascending Colon Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola Phase 2
2
Loperamide Approved 53179-11-6 3955
3 Gastrointestinal Agents
4 Antidiarrheals

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Novel Technique of Hand-assisted Laparoscopic Right Hemicolectomy With Complete Mesocolic Excision and Central Vascular Ligation for Right Colon Cancer: A Randomized Controlled Trial Recruiting NCT02625272 Phase 2
2 Randomized Clinical Trial Comparing Isoperistaltic Versus Antiperistaltic Side to Side Anastomosis After Right Laparoscopic Hemicolectomy for Cancer. Unknown status NCT02309931
3 A Prospective Randomized Controlled Clinical Study of Laparoscopic Right Hemicolectomy Using the Caudal-to-cranial Approach Recruiting NCT02949440

Search NIH Clinical Center for Ascending Colon Cancer

Genetic Tests for Ascending Colon Cancer

Anatomical Context for Ascending Colon Cancer

MalaCards organs/tissues related to Ascending Colon Cancer:

40
Colon, Liver, Ovary, Lymph Node, Appendix, Lung, Small Intestine

Publications for Ascending Colon Cancer

Articles related to Ascending Colon Cancer:

(show top 50) (show all 269)
# Title Authors PMID Year
1
Case report of ascending colon cancer and multiple jejunal GISTs in a patient with neurofibromatosis type 1 (NF1). 61
31805970 2019
2
Improvement of anaphylactoid purpura in a patient with ascending colon cancer after colectomy. 61
30117628 2019
3
Ascending Colon Cancer with Pathologically Confirmed Tumor Thrombosis of Superior Mesenteric Vein: A Case Report. 61
30992420 2019
4
Preoperative radiation as part of a multidisciplinary strategy for a medically inoperable patient with a bleeding colon cancer. 61
31439568 2019
5
The valdoni technique for bowel anastomosis. A rare complication. 61
31316770 2019
6
Primary tumor of the ureteral stump after a radical nephrectomy for renal cell carcinoma: case report and literature review. 61
31218189 2019
7
Mediastinal recurrence after curative resection of colon cancer: A case report and review of literature. 61
29933725 2019
8
[A Case of Ascending Colon Cancer Probably Arising from a Diverticulum]. 61
31296831 2019
9
Multiple primary malignancies of six organs in a Japanese male patient: A case report. 61
30967945 2019
10
A successful case of laparoscopic colorectal cancer resection in an elderly patient with factor XI deficiency. 61
31119406 2019
11
Association between KRAS G13D mutations and anastomotic recurrence in colorectal cancer: Two case reports. 61
30896620 2019
12
Is it Possible to Successfully Treat Locally Advanced Colon Cancer Using Pre-Operative Chemoradiotherapy? 61
30408944 2019
13
Laparoscopic right colectomy for a patient with situs inversus totalis. 61
30949333 2019
14
[Carcinoma of the Ascending Colon Showing Rapid Progression of Disseminated Carcinomatosis of the Bone Marrow-Report of a Case]. 61
30914535 2019
15
Solitary colonic metastasis from primary lung adenocarcinoma first presenting as intestinal obstruction: A case report. 61
30653118 2019
16
[A Case of Type 4 Ascending Colon Cancer Showing Early Postoperative Lymphangitis Carcinomatosa]. 61
30765667 2019
17
Laparoscopic right hemicolectomy for a colon cancer patient with an ileal conduit. 61
29624907 2019
18
[A Case of Metachronous Metastasis to the Pancreas from Ascending Colon Cancer after Subtotal Stomach-Preserving Pancreaticoduodenectomy(SSPPD)]. 61
30765666 2019
19
Peritoneal dissemination of ascending colon cancer demonstrating relapse-free survival for 40 months with panitumumab monotherapy: A case report. 61
31103951 2019
20
[A Case of Metastasis of Ascending Colon Cancer to the Small Intestine That Was Diagnosed Based on Ileus]. 61
30692351 2018
21
[A Case of Long-Term Survival in a Patient with Ascending Colon Cancer and Synchronous Multiple Liver Metastases after Multimodality Therapy Including Multiple Hepatectomy]. 61
30692499 2018
22
[A Case of Ascending Colon Cancer with Hepatic Metastases Showing Remarkable Efficacy of CapeOX plus Bevacizumab]. 61
30692304 2018
23
[A Case of Simultaneous Recurrence of Colon Cancer at the Drain Placement and Anastomotic Sites Postoperatively]. 61
30692386 2018
24
Three-dimensional computed tomographic angiography with computed tomographic colonography for laparoscopic colorectal surgery. 61
30218252 2018
25
[A Case of Ascending Colon Cancer Recurrence with Para-Aortic Lymph Node Metastases That Was Successfully Treated with Resection and Adjuvant Chemotherapy]. 61
30587735 2018
26
[A Case of Recurrent Hyperammonemic Encephalopathy during Adjuvant Chemotherapy(Modified FOLFOX6)for Colorectal Cancer]. 61
30449860 2018
27
Severe adverse events due to dihydropyrimidine dehydrogenase deficiency in a Japanese patient with colon cancer taking capecitabine: a case report. 61
31149530 2018
28
External auditory canal lesion: colorectal metastatic adenocarcinoma. 61
30249727 2018
29
Spontaneous regression of colorectal liver metastasis. 61
29546568 2018
30
Case of laparoscopic right hemicolectomy for ascending colon cancer after aortic graft replacement and revascularization of the superior mesenteric artery. 61
29322641 2018
31
[A Case of Recurrent Ascending Colon Cancer with Concomitant Dementia Successfully Treated with Chemotherapy]. 61
30158422 2018
32
[Changes in diameter of superior mesenteric vein and gastrocolic trunk in patients with cecum-ascending colon cancer]. 61
29968246 2018
33
Pathological complete response of locally advanced colon cancer after preoperative radiotherapy: a case report and narrative review of the literature. 61
29904815 2018
34
Clinical Significance of Lymph Node Metastasis in the Mesentery of the Terminal Ileum in Patients With Right-sided Colon Tumors at Different Locations. 61
29664799 2018
35
A rare case of ascending colon adenocarcinoma incarcerated in an inguinoscrotal hernia: case report and literature review. 61
29785528 2018
36
Single-stage laparoscopic surgery for bilateral organ tumors using a transumbilical approach with a zigzag incision: a report of two cases. 61
29716558 2018
37
[A Case of Synchronous Liver Metastasis of Ascending Colon Cancer with Pathological Complete Response to S-1/Oxaliplatin (SOX) and Bevacizumab]. 61
30026455 2018
38
[Three Long-Surviving Cases of Peritoneal Metastasis after Colorectal Cancer Resection]. 61
29483446 2018
39
Metastasis of pancreatic cancer within primary colon cancer by overtaking the stromal microenvironment. 61
31938443 2018
40
[A Case of Ascending Colon Cancer with Lynch Syndrome Who Underwent XELOX Adjuvant Chemotherapy]. 61
29362345 2018
41
A case of ascending colon cancer accompanied with tumor thrombosis in the superior mesenteric vein treated with right hemicolectomy and greater saphenous vein grafting. 61
30261478 2018
42
The Use of CT-Guided Marking for the Laparoscopic Resection of a Solitary Retroperitoneal Metastasis of Colon Cancer. 61
30087907 2018
43
Ascending colon cancer with synchronous external iliac and inguinal lymph node metastases but without regional lymph node metastasis: a case report and brief literature review. 61
28220469 2017
44
[A Case of Synchronous Multiple Liver Metastases from Ascending Colon Cancer Showing Pathological Complete Response to CapeOX Treatment]. 61
29394818 2017
45
[A Case of Ascending Colon Cancer with Synchronous Liver Metastases and Peritoneal Dissemination]. 61
29394555 2017
46
[Severe Therapy-Related Pancytopenia Caused by UFT and LV in a Patient with Ascending Colon Cancer]. 61
29394647 2017
47
[Two Cases of Single-Incision Laparoscopic Ileocecal Resection for Patients over 90 with Colon Cancer]. 61
29394661 2017
48
[A Case of Curatively Resected Ascending Colon Cancer with Ovarian Metastasis and Peritoneal Dissemination after Chemotherapy]. 61
29394751 2017
49
[A Case of Curatively Resected Ascending Colon Cancer after Long-Term Chemotherapy Found in Abdominal Trauma]. 61
29394769 2017
50
[A Case of a Two-Stage Hepatectomy for Irresectable Colorectal Cancer Liver Metastases]. 61
29394831 2017

Variations for Ascending Colon Cancer

ClinVar genetic disease variations for Ascending Colon Cancer:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 MSH2 NM_000251.2(MSH2):c.2038C>T (p.Arg680Ter)SNV Pathogenic 36572 rs63749932 2:47703538-47703538 2:47476399-47476399
2 APC NM_000038.6(APC):c.6553A>G (p.Ser2185Gly)SNV Uncertain significance 411410 rs1060503292 5:112177844-112177844 5:112842147-112842147

Expression for Ascending Colon Cancer

Search GEO for disease gene expression data for Ascending Colon Cancer.

Pathways for Ascending Colon Cancer

Pathways related to Ascending Colon Cancer according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.64 MSH2 MLH1 KRAS HRAS
2
Show member pathways
12.52 MSH2 MLH1 KRAS HRAS
3 12.43 MSH2 MLH1 KRAS HRAS
4
Show member pathways
12.12 MLH1 KRAS HRAS CDX2
5
Show member pathways
11.88 KRAS HRAS CEACAM5
6 11.72 MSH2 MLH1 KRAS
7 11.27 UVRAG KRAS HRAS
8 11.09 KRAS HRAS
9 11.02 KRAS HRAS
10 11.01 KRAS HRAS
11 10.99 MSH2 MLH1
12
Show member pathways
10.97 KRAS HRAS
13
Show member pathways
10.91 KRAS HRAS
14 10.79 KRAS HRAS
15 10.71 KRAS HRAS
16 10.56 KRAS HRAS
17 9.74 KRAS HRAS

GO Terms for Ascending Colon Cancer

Cellular components related to Ascending Colon Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 8.62 MSH2 MLH1

Biological processes related to Ascending Colon Cancer according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.8 KRAS HRAS CSF3 CDX2
2 negative regulation of neuron apoptotic process GO:0043524 9.61 MSH2 KRAS HRAS
3 mismatch repair GO:0006298 9.51 MSH2 MLH1
4 regulation of long-term neuronal synaptic plasticity GO:0048169 9.48 KRAS HRAS
5 positive regulation of actin cytoskeleton reorganization GO:2000251 9.46 HRAS CSF3
6 isotype switching GO:0045190 9.4 MSH2 MLH1
7 somatic hypermutation of immunoglobulin genes GO:0016446 9.37 MSH2 MLH1
8 positive regulation of isotype switching to IgG isotypes GO:0048304 9.32 MSH2 MLH1
9 response to isolation stress GO:0035900 9.26 KRAS HRAS
10 positive regulation of isotype switching to IgA isotypes GO:0048298 9.16 MSH2 MLH1
11 somatic recombination of immunoglobulin gene segments GO:0016447 8.96 MSH2 MLH1
12 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 8.62 MSH2 MLH1

Molecular functions related to Ascending Colon Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatched DNA binding GO:0030983 8.96 MSH2 MLH1
2 guanine/thymine mispair binding GO:0032137 8.62 MSH2 MLH1

Sources for Ascending Colon Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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