MCID: ASC004
MIFTS: 36

Ascending Colon Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Ascending Colon Cancer

MalaCards integrated aliases for Ascending Colon Cancer:

Name: Ascending Colon Cancer 12 15
Malignant Tumor of Ascending Colon 12 6
Malignant Neoplasm of Ascending Colon 72
Malignant Neoplasm of Right Colon 12
Ca Ascending Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:218
ICD9CM 35 153.6
SNOMED-CT 68 93683002
ICD10 33 C18.2
UMLS 72 C0153439

Summaries for Ascending Colon Cancer

MalaCards based summary : Ascending Colon Cancer, also known as malignant tumor of ascending colon, is related to lynch syndrome and colorectal cancer. An important gene associated with Ascending Colon Cancer is MSH2 (MutS Homolog 2), and among its related pathways/superpathways are Integrated Breast Cancer Pathway and Autophagy - animal. The drugs Cola and Loperamide have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and lymph node.

Related Diseases for Ascending Colon Cancer

Diseases related to Ascending Colon Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 lynch syndrome 29.4 MSH2 KRAS
2 colorectal cancer 10.8
3 tubular adenocarcinoma 10.3
4 ileus 10.2
5 cecum adenocarcinoma 10.1 MSH2 KRAS
6 intestinal benign neoplasm 10.1 MSH2 KRAS
7 small intestine cancer 10.1 MSH2 KRAS
8 colorectal adenoma 10.0 MSH2 KRAS
9 bladder cancer 10.0
10 colitis 10.0
11 rectum cancer 10.0
12 situs inversus 10.0
13 peritonitis 10.0
14 abdominal wall defect 10.0
15 colonic disease 10.0 MSH2 KRAS
16 colorectal adenocarcinoma 10.0 MSH2 KRAS
17 intestinal disease 10.0 MSH2 KRAS
18 gastrointestinal system cancer 10.0 MSH2 KRAS
19 bladder diverticulum 9.9
20 polykaryocytosis inducer 9.9
21 dihydropyrimidine dehydrogenase deficiency 9.9
22 myelodysplastic syndrome 9.9
23 cholangiocarcinoma 9.9
24 aspiration pneumonia 9.9
25 hyperphosphatemia 9.9
26 exanthem 9.9
27 thrombosis 9.9
28 dermatomyositis 9.9
29 microinvasive gastric cancer 9.9
30 hydronephrosis 9.9
31 cholecystolithiasis 9.9
32 respiratory failure 9.9
33 neutropenia 9.9
34 pancytopenia 9.9
35 dementia 9.9
36 obstructive jaundice 9.9
37 cecum carcinoma 9.9
38 hyperuricemia 9.9
39 intestinal perforation 9.9
40 colon adenocarcinoma 9.9
41 mucinous adenocarcinoma 9.9
42 rhabdomyosarcoma 9.9
43 angiomyolipoma 9.9
44 hepatic angiomyolipoma 9.9
45 purpura 9.9
46 liposarcoma 9.9
47 cellulitis 9.9
48 appendix adenocarcinoma 9.9
49 intrahepatic cholangiocarcinoma 9.9
50 diverticulitis 9.9

Comorbidity relations with Ascending Colon Cancer via Phenotypic Disease Network (PDN): (show all 11)


Active Peptic Ulcer Disease Cecal Benign Neoplasm
Colon Carcinoma in Situ Colorectal Cancer
Deficiency Anemia Hepatic Flexure Cancer
Intestinal Obstruction Iron Deficiency Anemia
Paralytic Ileus Rectosigmoid Junction Neoplasm
Transverse Colon Cancer

Graphical network of the top 20 diseases related to Ascending Colon Cancer:



Diseases related to Ascending Colon Cancer

Symptoms & Phenotypes for Ascending Colon Cancer

Drugs & Therapeutics for Ascending Colon Cancer

Drugs for Ascending Colon Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola Phase 2
2
Loperamide Approved 53179-11-6 3955
3 Gastrointestinal Agents
4 Antidiarrheals

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Novel Technique of Hand-assisted Laparoscopic Right Hemicolectomy With Complete Mesocolic Excision and Central Vascular Ligation for Right Colon Cancer: A Randomized Controlled Trial Recruiting NCT02625272 Phase 2
2 Randomized Clinical Trial Comparing Isoperistaltic Versus Antiperistaltic Side to Side Anastomosis After Right Laparoscopic Hemicolectomy for Cancer. Unknown status NCT02309931
3 A Prospective Randomized Controlled Clinical Study of Laparoscopic Right Hemicolectomy Using the Caudal-to-cranial Approach Recruiting NCT02949440

Search NIH Clinical Center for Ascending Colon Cancer

Genetic Tests for Ascending Colon Cancer

Anatomical Context for Ascending Colon Cancer

MalaCards organs/tissues related to Ascending Colon Cancer:

41
Colon, Liver, Lymph Node, Lung, Bone, Small Intestine, Bone Marrow

Publications for Ascending Colon Cancer

Articles related to Ascending Colon Cancer:

(show top 50) (show all 266)
# Title Authors PMID Year
1
The valdoni technique for bowel anastomosis. A rare complication. 38
31316770 2019
2
Primary tumor of the ureteral stump after a radical nephrectomy for renal cell carcinoma: case report and literature review. 38
31218189 2019
3
Mediastinal recurrence after curative resection of colon cancer: A case report and review of literature. 38
29933725 2019
4
[A Case of Ascending Colon Cancer Probably Arising from a Diverticulum]. 38
31296831 2019
5
Multiple primary malignancies of six organs in a Japanese male patient: A case report. 38
30967945 2019
6
A successful case of laparoscopic colorectal cancer resection in an elderly patient with factor XI deficiency. 38
31119406 2019
7
Ascending Colon Cancer with Pathologically Confirmed Tumor Thrombosis of Superior Mesenteric Vein: A Case Report. 38
30992420 2019
8
Is it Possible to Successfully Treat Locally Advanced Colon Cancer Using Pre-Operative Chemoradiotherapy? 38
30408944 2019
9
Association between KRAS G13D mutations and anastomotic recurrence in colorectal cancer: Two case reports. 38
30896620 2019
10
Laparoscopic right colectomy for a patient with situs inversus totalis. 38
30949333 2019
11
[Carcinoma of the Ascending Colon Showing Rapid Progression of Disseminated Carcinomatosis of the Bone Marrow-Report of a Case]. 38
30914535 2019
12
Solitary colonic metastasis from primary lung adenocarcinoma first presenting as intestinal obstruction: A case report. 38
30653118 2019
13
Laparoscopic right hemicolectomy for a colon cancer patient with an ileal conduit. 38
29624907 2019
14
[A Case of Type 4 Ascending Colon Cancer Showing Early Postoperative Lymphangitis Carcinomatosa]. 38
30765667 2019
15
Peritoneal dissemination of ascending colon cancer demonstrating relapse-free survival for 40 months with panitumumab monotherapy: A case report. 38
31103951 2019
16
[A Case of Metachronous Metastasis to the Pancreas from Ascending Colon Cancer after Subtotal Stomach-Preserving Pancreaticoduodenectomy(SSPPD)]. 38
30765666 2019
17
[A Case of Metastasis of Ascending Colon Cancer to the Small Intestine That Was Diagnosed Based on Ileus]. 38
30692351 2018
18
[A Case of Ascending Colon Cancer Recurrence with Para-Aortic Lymph Node Metastases That Was Successfully Treated with Resection and Adjuvant Chemotherapy]. 38
30587735 2018
19
[A Case of Ascending Colon Cancer with Hepatic Metastases Showing Remarkable Efficacy of CapeOX plus Bevacizumab]. 38
30692304 2018
20
[A Case of Simultaneous Recurrence of Colon Cancer at the Drain Placement and Anastomotic Sites Postoperatively]. 38
30692386 2018
21
Three-dimensional computed tomographic angiography with computed tomographic colonography for laparoscopic colorectal surgery. 38
30218252 2018
22
[A Case of Long-Term Survival in a Patient with Ascending Colon Cancer and Synchronous Multiple Liver Metastases after Multimodality Therapy Including Multiple Hepatectomy]. 38
30692499 2018
23
[A Case of Recurrent Hyperammonemic Encephalopathy during Adjuvant Chemotherapy(Modified FOLFOX6)for Colorectal Cancer]. 38
30449860 2018
24
Severe adverse events due to dihydropyrimidine dehydrogenase deficiency in a Japanese patient with colon cancer taking capecitabine: a case report. 38
31149530 2018
25
External auditory canal lesion: colorectal metastatic adenocarcinoma. 38
30249727 2018
26
Spontaneous regression of colorectal liver metastasis. 38
29546568 2018
27
Case of laparoscopic right hemicolectomy for ascending colon cancer after aortic graft replacement and revascularization of the superior mesenteric artery. 38
29322641 2018
28
Improvement of anaphylactoid purpura in a patient with ascending colon cancer after colectomy. 38
30117628 2018
29
[A Case of Recurrent Ascending Colon Cancer with Concomitant Dementia Successfully Treated with Chemotherapy]. 38
30158422 2018
30
Pathological complete response of locally advanced colon cancer after preoperative radiotherapy: a case report and narrative review of the literature. 38
29904815 2018
31
[Changes in diameter of superior mesenteric vein and gastrocolic trunk in patients with cecum-ascending colon cancer]. 38
29968246 2018
32
Clinical Significance of Lymph Node Metastasis in the Mesentery of the Terminal Ileum in Patients With Right-sided Colon Tumors at Different Locations. 38
29664799 2018
33
[A Case of Synchronous Liver Metastasis of Ascending Colon Cancer with Pathological Complete Response to S-1/Oxaliplatin (SOX) and Bevacizumab]. 38
30026455 2018
34
Single-stage laparoscopic surgery for bilateral organ tumors using a transumbilical approach with a zigzag incision: a report of two cases. 38
29716558 2018
35
A rare case of ascending colon adenocarcinoma incarcerated in an inguinoscrotal hernia: case report and literature review. 38
29785528 2018
36
[Three Long-Surviving Cases of Peritoneal Metastasis after Colorectal Cancer Resection]. 38
29483446 2018
37
[A Case of Ascending Colon Cancer with Lynch Syndrome Who Underwent XELOX Adjuvant Chemotherapy]. 38
29362345 2018
38
The Use of CT-Guided Marking for the Laparoscopic Resection of a Solitary Retroperitoneal Metastasis of Colon Cancer. 38
30087907 2018
39
A case of ascending colon cancer accompanied with tumor thrombosis in the superior mesenteric vein treated with right hemicolectomy and greater saphenous vein grafting. 38
30261478 2018
40
Ascending colon cancer with synchronous external iliac and inguinal lymph node metastases but without regional lymph node metastasis: a case report and brief literature review. 38
28220469 2017
41
[A Case of Synchronous Multiple Liver Metastases from Ascending Colon Cancer Showing Pathological Complete Response to CapeOX Treatment]. 38
29394818 2017
42
[A Case of Ascending Colon Cancer with Synchronous Liver Metastases and Peritoneal Dissemination]. 38
29394555 2017
43
[Severe Therapy-Related Pancytopenia Caused by UFT and LV in a Patient with Ascending Colon Cancer]. 38
29394647 2017
44
[Two Cases of Single-Incision Laparoscopic Ileocecal Resection for Patients over 90 with Colon Cancer]. 38
29394661 2017
45
[A Case of Curatively Resected Ascending Colon Cancer with Ovarian Metastasis and Peritoneal Dissemination after Chemotherapy]. 38
29394751 2017
46
[A Case of Curatively Resected Ascending Colon Cancer after Long-Term Chemotherapy Found in Abdominal Trauma]. 38
29394769 2017
47
[A Case of a Two-Stage Hepatectomy for Irresectable Colorectal Cancer Liver Metastases]. 38
29394831 2017
48
[A Case of Huge Colon Cancer Accompanied with Severe Hypoproteinemia]. 38
29394556 2017
49
[A Case with Solitary Brain Metastatic Tumor from Colon Cancer]. 38
29394643 2017
50
[Anti-EGFR Antibody Combination Chemotherapy Was Effective against Locally Advanced Ascending Colon Cancer as Well as a Recurrent Lesion - A Case Report]. 38
29066705 2017

Variations for Ascending Colon Cancer

ClinVar genetic disease variations for Ascending Colon Cancer:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 MSH2 NM_000251.2(MSH2): c.2038C> T (p.Arg680Ter) single nucleotide variant Pathogenic rs63749932 2:47703538-47703538 2:47476399-47476399
2 APC NM_000038.6(APC): c.6553A> G (p.Ser2185Gly) single nucleotide variant Uncertain significance rs1060503292 5:112177844-112177844 5:112842147-112842147

Expression for Ascending Colon Cancer

Search GEO for disease gene expression data for Ascending Colon Cancer.

Pathways for Ascending Colon Cancer

Pathways related to Ascending Colon Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.34 MSH2 KRAS
2 11.09 UVRAG KRAS
3 10.49 UPK3A KRAS

GO Terms for Ascending Colon Cancer

Biological processes related to Ascending Colon Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 8.62 MSH2 KRAS

Sources for Ascending Colon Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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