MCID: ASC004
MIFTS: 42

Ascending Colon Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Ascending Colon Cancer

MalaCards integrated aliases for Ascending Colon Cancer:

Name: Ascending Colon Cancer 12 15
Malignant Tumor of Ascending Colon 12 6
Malignant Neoplasm of Ascending Colon 71
Malignant Neoplasm of Right Colon 12
Ca Ascending Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:218
ICD9CM 34 153.6
SNOMED-CT 67 363412000
ICD10 32 C18.2
UMLS 71 C0153439

Summaries for Ascending Colon Cancer

MalaCards based summary : Ascending Colon Cancer, also known as malignant tumor of ascending colon, is related to cholecystolithiasis and exanthem. An important gene associated with Ascending Colon Cancer is MSH2 (MutS Homolog 2), and among its related pathways/superpathways are TCR Signaling (Qiagen) and Endometrial cancer. The drugs Fluoxymesterone and Cola have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and lymph node, and related phenotypes are digestive/alimentary and neoplasm

Related Diseases for Ascending Colon Cancer

Diseases related to Ascending Colon Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 231)
# Related Disease Score Top Affiliating Genes
1 cholecystolithiasis 30.3 UVRAG CEACAM5
2 exanthem 29.8 KRAS HRAS CSF3
3 cholangiocarcinoma 29.6 KRAS CEACAM5 CDX2
4 microinvasive gastric cancer 29.5 MLH1 CEACAM5 CDX2
5 neurofibromatosis 29.2 MSH2 MLH1 KRAS HRAS
6 intestinal obstruction 29.2 CEACAM5 CDX2 APOLD1
7 appendix adenocarcinoma 29.2 KRAS HRAS CEACAM5 CDX2
8 lynch syndrome 29.2 MSH2 MLH1 KRAS HRAS
9 mucinous adenocarcinoma 29.1 MLH1 KRAS CEACAM5 CDX2
10 cecum carcinoma 28.8 MSH2 MLH1 KRAS HRAS CEACAM5
11 rectum cancer 28.1 MSH2 MLH1 KRAS HRAS CEACAM5 APOLD1
12 colorectal cancer 10.9
13 tubular adenocarcinoma 10.3
14 urachal adenocarcinoma 10.3 KRAS CEACAM5
15 immature teratoma of ovary 10.3 KRAS CEACAM5
16 mature teratoma 10.3 KRAS CEACAM5
17 bile acid synthesis defect, congenital, 5 10.2 KRAS CEACAM5
18 trachea carcinoma in situ 10.2 KRAS HRAS
19 extrahepatic bile duct adenoma 10.2 MSH2 MLH1
20 cobblestone retinal degeneration 10.2 KRAS HRAS
21 ectomesenchymoma 10.2 MSH2 HRAS
22 adult teratoma 10.2 HRAS CEACAM5
23 renal pelvis transitional cell carcinoma 10.2 MSH2 MLH1
24 appendix carcinoid tumor 10.2 MSH2 MLH1
25 familial colorectal cancer 10.2 MSH2 MLH1
26 ampulla of vater neoplasm 10.2 KRAS HRAS
27 ureter adenocarcinoma 10.2 CEACAM5 CDX2
28 laryngeal mucoepidermoid carcinoma 10.2 CEACAM5 CDX2
29 pancreatic foamy gland adenocarcinoma 10.2 CEACAM5 CDX2
30 periampullary adenoma 10.2 KRAS HRAS
31 mucinous adenofibroma 10.2 CEACAM5 CDX2
32 adenosquamous lung carcinoma 10.2 KRAS HRAS
33 urinary bladder villous adenoma 10.2 CEACAM5 CDX2
34 acneiform dermatitis 10.2 KRAS HRAS
35 thymus adenocarcinoma 10.2 CEACAM5 CDX2
36 vulva adenocarcinoma 10.2 CEACAM5 CDX2
37 ileus 10.2
38 gallbladder benign neoplasm 10.2 KRAS HRAS
39 cystitis cystica 10.2 CEACAM5 CDX2
40 mucinous intrahepatic cholangiocarcinoma 10.2 CEACAM5 CDX2
41 anal paget's disease 10.2 CEACAM5 CDX2
42 mucinous lung adenocarcinoma 10.2 KRAS HRAS
43 female urethral cancer 10.2 CEACAM5 CDX2
44 mucinous ovarian cystadenoma 10.2 CEACAM5 CDX2
45 wolffian duct adenocarcinoma 10.2 KRAS HRAS
46 colorectal cancer, hereditary nonpolyposis, type 6 10.2 MSH2 MLH1
47 krukenberg carcinoma 10.2 CEACAM5 CDX2
48 autosomal dominant non-syndromic intellectual disability 8 10.2 MSH2 MLH1
49 lower lip cancer 10.2 MSH2 MLH1
50 sebaceous gland neoplasm 10.2 MSH2 MLH1

Comorbidity relations with Ascending Colon Cancer via Phenotypic Disease Network (PDN): (show all 11)


Active Peptic Ulcer Disease Cecal Benign Neoplasm
Colon Carcinoma in Situ Colorectal Cancer
Deficiency Anemia Hepatic Flexure Cancer
Intestinal Obstruction Iron Deficiency Anemia
Paralytic Ileus Rectosigmoid Junction Neoplasm
Transverse Colon Cancer

Graphical network of the top 20 diseases related to Ascending Colon Cancer:



Diseases related to Ascending Colon Cancer

Symptoms & Phenotypes for Ascending Colon Cancer

MGI Mouse Phenotypes related to Ascending Colon Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.43 CDX2 HRAS KRAS MLH1 MSH2 SPDEF
2 neoplasm MP:0002006 9.02 CDX2 HRAS KRAS MLH1 MSH2

Drugs & Therapeutics for Ascending Colon Cancer

Drugs for Ascending Colon Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluoxymesterone Approved, Illicit Phase 2 76-43-7 6446
2 Cola Phase 2
3
Loperamide Approved 53179-11-6 3955
4 Antidiarrheals
5 Gastrointestinal Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Novel Technique of Hand-assisted Laparoscopic Right Hemicolectomy With Complete Mesocolic Excision and Central Vascular Ligation for Right Colon Cancer: A Randomized Controlled Trial Unknown status NCT02625272 Phase 2
2 Randomized Clinical Trial Comparing Isoperistaltic Versus Antiperistaltic Side to Side Anastomosis After Right Laparoscopic Hemicolectomy for Cancer. Unknown status NCT02309931
3 A Prospective Randomized Controlled Clinical Study of Laparoscopic Right Hemicolectomy Using the Caudal-to-cranial Approach Recruiting NCT02949440

Search NIH Clinical Center for Ascending Colon Cancer

Genetic Tests for Ascending Colon Cancer

Anatomical Context for Ascending Colon Cancer

MalaCards organs/tissues related to Ascending Colon Cancer:

40
Colon, Liver, Lymph Node, Lung, Bone, Appendix, Bone Marrow

Publications for Ascending Colon Cancer

Articles related to Ascending Colon Cancer:

(show top 50) (show all 287)
# Title Authors PMID Year
1
[A Case of Severe Aortic Thrombosis during the First Chemotherapy Regimen of CapeOX plus Bevacizumab for Metastatic Colon Cancer]. 61
32541181 2020
2
Cutaneous metastasis of ascending colon cancer harboring a BRAF V600E mutation: A rare case report. 61
32481270 2020
3
Subtotal gastrectomy for gastric tube cancer using intraoperative indocyanine green fluorescence method. 61
32480340 2020
4
Risk Factor Profiles Differ for Cancers of Different Regions of the Colorectum. 61
32247020 2020
5
Intramural metastasis to the appendix from ascending colon cancer: a case report. 61
32277313 2020
6
Correction to: Intramural metastasis to the appendix from ascending colon cancer: a case report. 61
32314146 2020
7
[A Case of Intussusception Caused by Ascending Colon Cancer in an Elderly Woman]. 61
32389972 2020
8
[A Case of Laparoscopic Ileocecal Resection for Ascending Colon Cancer with Portosystemic Shunt]. 61
32381940 2020
9
A two-step surgery and a multidisciplinary approach in a centenarian patient with an acute presentation of right colon cancer. 61
32188448 2020
10
[A Case of Ascending Colon Cancer with Synchronous Unresectable Liver Metastasis Maintaining a Long-Term Stable Disease State after Discontinuing Chemotherapy]. 61
32381962 2020
11
[A Case of Complete Pathological Response in a Patient with Advanced Ascending Colon Cancer That Invaded the Liver and Duodenum after FOLFOXIRI plus Bevacizumab Chemotherapy]. 61
32381968 2020
12
[A Case of Colon Cancer with Peritoneal Dissemination and Liver Metastasis That Responded to Comprehensive Treatment by Perioperative Chemotherapy and Cytoreductive Surgery]. 61
32381992 2020
13
[A Case of Unresectable Ascending Colon Cancer Treated with a Newly Devised Bypass Method]. 61
32381991 2020
14
[Tumor Embolisms from Colon Cancer Detected on Transcatheter Examination-A Case Report]. 61
32381884 2020
15
A Rare Case of Moderately Differentiated Adenocarcinoma With PD-L1 Overexpression and a Heterogeneous LELC Component in the Ascending Colon. 61
32095077 2020
16
[A Case Report on Larynx-Preserving Surgery with Tracheal Resection of an Advanced Esophageal Cancer with Tracheal Invasion]. 61
32156988 2019
17
[Successful Treatment of Necrotizing Fasciitis Due to Ascending Colon Cancer-A Case Report]. 61
32157003 2019
18
[A Case of Histological Complete Remission after Chemotherapy for Paraaortic Lymph Node Recurrence after Colon Cancer Surgery]. 61
32156982 2019
19
Case report of ascending colon cancer and multiple jejunal GISTs in a patient with neurofibromatosis type 1 (NF1). 61
31805970 2019
20
Improvement of anaphylactoid purpura in a patient with ascending colon cancer after colectomy. 61
30117628 2019
21
Ascending Colon Cancer with Pathologically Confirmed Tumor Thrombosis of Superior Mesenteric Vein: A Case Report. 61
30992420 2019
22
Preoperative radiation as part of a multidisciplinary strategy for a medically inoperable patient with a bleeding colon cancer. 61
31439568 2019
23
The valdoni technique for bowel anastomosis. A rare complication. 61
31316770 2019
24
Primary tumor of the ureteral stump after a radical nephrectomy for renal cell carcinoma: case report and literature review. 61
31218189 2019
25
[A Case of Ascending Colon Cancer Probably Arising from a Diverticulum]. 61
31296831 2019
26
Mediastinal recurrence after curative resection of colon cancer: A case report and review of literature. 61
29933725 2019
27
Multiple primary malignancies of six organs in a Japanese male patient: A case report. 61
30967945 2019
28
A successful case of laparoscopic colorectal cancer resection in an elderly patient with factor XI deficiency. 61
31119406 2019
29
Association between KRAS G13D mutations and anastomotic recurrence in colorectal cancer: Two case reports. 61
30896620 2019
30
Is it Possible to Successfully Treat Locally Advanced Colon Cancer Using Pre-Operative Chemoradiotherapy? 61
30408944 2019
31
Laparoscopic right colectomy for a patient with situs inversus totalis. 61
30949333 2019
32
[Carcinoma of the Ascending Colon Showing Rapid Progression of Disseminated Carcinomatosis of the Bone Marrow-Report of a Case]. 61
30914535 2019
33
Solitary colonic metastasis from primary lung adenocarcinoma first presenting as intestinal obstruction: A case report. 61
30653118 2019
34
[A Case of Type 4 Ascending Colon Cancer Showing Early Postoperative Lymphangitis Carcinomatosa]. 61
30765667 2019
35
Laparoscopic right hemicolectomy for a colon cancer patient with an ileal conduit. 61
29624907 2019
36
Peritoneal dissemination of ascending colon cancer demonstrating relapse-free survival for 40 months with panitumumab monotherapy: A case report. 61
31103951 2019
37
[A Case of Metachronous Metastasis to the Pancreas from Ascending Colon Cancer after Subtotal Stomach-Preserving Pancreaticoduodenectomy(SSPPD)]. 61
30765666 2019
38
[A Case of Metastasis of Ascending Colon Cancer to the Small Intestine That Was Diagnosed Based on Ileus]. 61
30692351 2018
39
[A Case of Ascending Colon Cancer with Hepatic Metastases Showing Remarkable Efficacy of CapeOX plus Bevacizumab]. 61
30692304 2018
40
[A Case of Simultaneous Recurrence of Colon Cancer at the Drain Placement and Anastomotic Sites Postoperatively]. 61
30692386 2018
41
Three-dimensional computed tomographic angiography with computed tomographic colonography for laparoscopic colorectal surgery. 61
30218252 2018
42
[A Case of Ascending Colon Cancer Recurrence with Para-Aortic Lymph Node Metastases That Was Successfully Treated with Resection and Adjuvant Chemotherapy]. 61
30587735 2018
43
[A Case of Long-Term Survival in a Patient with Ascending Colon Cancer and Synchronous Multiple Liver Metastases after Multimodality Therapy Including Multiple Hepatectomy]. 61
30692499 2018
44
[A Case of Recurrent Hyperammonemic Encephalopathy during Adjuvant Chemotherapy(Modified FOLFOX6)for Colorectal Cancer]. 61
30449860 2018
45
Severe adverse events due to dihydropyrimidine dehydrogenase deficiency in a Japanese patient with colon cancer taking capecitabine: a case report. 61
31149530 2018
46
External auditory canal lesion: colorectal metastatic adenocarcinoma. 61
30249727 2018
47
Spontaneous regression of colorectal liver metastasis. 61
29546568 2018
48
Case of laparoscopic right hemicolectomy for ascending colon cancer after aortic graft replacement and revascularization of the superior mesenteric artery. 61
29322641 2018
49
[A Case of Recurrent Ascending Colon Cancer with Concomitant Dementia Successfully Treated with Chemotherapy]. 61
30158422 2018
50
[Changes in diameter of superior mesenteric vein and gastrocolic trunk in patients with cecum-ascending colon cancer]. 61
29968246 2018

Variations for Ascending Colon Cancer

ClinVar genetic disease variations for Ascending Colon Cancer:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 MSH2 NM_000251.3(MSH2):c.2038C>T (p.Arg680Ter)SNV Pathogenic 36572 rs63749932 2:47703538-47703538 2:47476399-47476399
2 APC NM_000038.6(APC):c.6553A>G (p.Ser2185Gly)SNV Uncertain significance 411410 rs1060503292 5:112177844-112177844 5:112842147-112842147

Expression for Ascending Colon Cancer

Search GEO for disease gene expression data for Ascending Colon Cancer.

Pathways for Ascending Colon Cancer

Pathways related to Ascending Colon Cancer according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.64 MSH2 MLH1 KRAS HRAS
2
Show member pathways
12.52 MSH2 MLH1 KRAS HRAS
3 12.43 MSH2 MLH1 KRAS HRAS
4
Show member pathways
12.12 MLH1 KRAS HRAS CDX2
5
Show member pathways
11.88 KRAS HRAS CEACAM5
6 11.72 MSH2 MLH1 KRAS
7 11.27 UVRAG KRAS HRAS
8 11.09 KRAS HRAS
9 11.02 KRAS HRAS
10 11.01 KRAS HRAS
11 10.99 MSH2 MLH1
12
Show member pathways
10.97 KRAS HRAS
13
Show member pathways
10.91 KRAS HRAS
14 10.79 KRAS HRAS
15 10.71 KRAS HRAS
16 10.56 KRAS HRAS
17 9.74 KRAS HRAS

GO Terms for Ascending Colon Cancer

Cellular components related to Ascending Colon Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 8.62 MSH2 MLH1

Biological processes related to Ascending Colon Cancer according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.8 KRAS HRAS CSF3 CDX2
2 negative regulation of neuron apoptotic process GO:0043524 9.61 MSH2 KRAS HRAS
3 mismatch repair GO:0006298 9.51 MSH2 MLH1
4 regulation of long-term neuronal synaptic plasticity GO:0048169 9.48 KRAS HRAS
5 positive regulation of actin cytoskeleton reorganization GO:2000251 9.46 HRAS CSF3
6 isotype switching GO:0045190 9.4 MSH2 MLH1
7 somatic hypermutation of immunoglobulin genes GO:0016446 9.37 MSH2 MLH1
8 positive regulation of isotype switching to IgG isotypes GO:0048304 9.32 MSH2 MLH1
9 response to isolation stress GO:0035900 9.26 KRAS HRAS
10 positive regulation of isotype switching to IgA isotypes GO:0048298 9.16 MSH2 MLH1
11 somatic recombination of immunoglobulin gene segments GO:0016447 8.96 MSH2 MLH1
12 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 8.62 MSH2 MLH1

Molecular functions related to Ascending Colon Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatched DNA binding GO:0030983 8.96 MSH2 MLH1
2 guanine/thymine mispair binding GO:0032137 8.62 MSH2 MLH1

Sources for Ascending Colon Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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