MCID: ASC009
MIFTS: 36

Ascites, Chylous

Categories: Rare diseases, Cardiovascular diseases, Fetal diseases

Aliases & Classifications for Ascites, Chylous

MalaCards integrated aliases for Ascites, Chylous:

Name: Ascites, Chylous 57
Chylous Ascites 76 53 59 73
Congenital Chylous Ascites 53 73
Ascites Chylous 55

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive


HPO:

32
ascites, chylous:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 57 208300
Orphanet 59 ORPHA1160
ICD10 via Orphanet 34 I89.8
MESH via Orphanet 45 D002915
UMLS via Orphanet 74 C0008732
MedGen 42 C0008732

Summaries for Ascites, Chylous

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 1160Disease definitionChylous ascites is a rare form of ascites caused by accumulation of lymph in the peritoneal cavity, usually due to intra-abdominal malignancy, liver cirrhosis or abdominal surgery complications, and present with painless but progressive abdominal distension, dyspnea and weight gain.Visit the Orphanet disease page for more resources.

MalaCards based summary : Ascites, Chylous, also known as chylous ascites, is related to peritonitis and pancreatitis. An important gene associated with Ascites, Chylous is SST (Somatostatin). The drugs Octreotide and Somatostatin have been mentioned in the context of this disorder. Affiliated tissues include liver, lymph node and heart, and related phenotypes are glaucoma and lymphedema

Wikipedia : 76 Ascites is the abnormal buildup of fluid in the abdomen. Technically, it is more than 25 mL of fluid in... more...

Description from OMIM: 208300

Related Diseases for Ascites, Chylous

Diseases related to Ascites, Chylous via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 peritonitis 10.4
2 pancreatitis 10.4
3 aneurysm 10.3
4 aortic aneurysm, familial abdominal, 1 10.2
5 aortic aneurysm 10.2
6 pericarditis 10.2
7 lymphoma 10.2
8 constrictive pericarditis 10.2
9 thrombosis 10.2
10 lymphangioleiomyomatosis 10.1
11 nephrotic syndrome 10.1
12 liver cirrhosis 10.1
13 lymphedema 10.1
14 acute pancreatitis 10.1
15 carcinoid syndrome 10.1
16 sarcoma 9.7

Graphical network of the top 20 diseases related to Ascites, Chylous:



Diseases related to Ascites, Chylous

Symptoms & Phenotypes for Ascites, Chylous

Symptoms via clinical synopsis from OMIM:

57
Abdomen:
chylous ascites, congenital

Eye:
bilateral glaucoma

Limbs:
arm swelling


Clinical features from OMIM:

208300

Human phenotypes related to Ascites, Chylous:

59 32 (show all 9)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 glaucoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0000501
2 lymphedema 59 32 hallmark (90%) Very frequent (99-80%) HP:0001004
3 subcutaneous nodule 59 32 frequent (33%) Frequent (79-30%) HP:0001482
4 ascites 59 32 hallmark (90%) Very frequent (99-80%) HP:0001541
5 pancreatitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001733
6 neoplasm 59 32 occasional (7.5%) Occasional (29-5%) HP:0002664
7 abnormality of the intestine 59 Occasional (29-5%)
8 chylous ascites 32 HP:0012281
9 abnormal intestine morphology 32 occasional (7.5%) HP:0002242

Drugs & Therapeutics for Ascites, Chylous

Drugs for Ascites, Chylous (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
2
Somatostatin Approved, Investigational Phase 2 38916-34-6, 51110-01-1 53481605
3 Antineoplastic Agents, Hormonal Phase 2
4 Gastrointestinal Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment With Octreotide in Patients With Lymphangioleiomyomatosis Completed NCT00005906 Phase 2 Octreotide
2 Chyle Leak After Pancreatic Surgery Recruiting NCT03079986 Not Applicable

Search NIH Clinical Center for Ascites, Chylous

Genetic Tests for Ascites, Chylous

Anatomical Context for Ascites, Chylous

MalaCards organs/tissues related to Ascites, Chylous:

41
Liver, Lymph Node, Heart, Testis, Pancreas, Prostate, B Cells

Publications for Ascites, Chylous

Articles related to Ascites, Chylous:

(show top 50) (show all 576)
# Title Authors Year
1
A young woman with steroid-responsive, IgG4-positive plasma cell-enriched cystic lymphangioma and chylous ascites. ( 29881573 )
2018
2
Val30Met Familial Amyloid Polyneuropathy, Heart Failure, and Chylous Ascites: An Unexpected Combination. ( 29880429 )
2018
3
Retroperitoneal Fibrosis as a Cause of Chylous Ascites. ( 29090239 )
2017
4
A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax. ( 28487786 )
2017
5
A rare cause of acute abdomen: Chylous ascites. ( 28740965 )
2017
6
Chylous Ascites in a Newborn with Gastroschisis. Case Report. ( 28083502 )
2017
7
Chylous Ascites and Chylothorax Caused by Constrictive Pericarditis. ( 29052575 )
2017
8
Chylous ascites in focal segmental glomerulosclerosis. ( 28314586 )
2017
9
In vitro fertilization and pregnancy management in a woman with acquired idiopathic chylous ascites. ( 28737271 )
2017
10
Does BLOODCARE Powder Prevent Postoperative Chylous Ascites After Lymphadenectomy for Gynecological Malignancies? ( 28763366 )
2017
11
Lercanidipine-induced chylous ascites: Case report and literature review. ( 28485829 )
2017
12
Disseminated lymphangiomatosis presenting as chylous ascites and diagnosed with endoscopic ultrasound. ( 27386481 )
2016
13
A case report of chylous ascites after gastric bypass for morbid obesity. ( 27846453 )
2016
14
Chylous Ascites in a Neonate with Hydrops Fetalis. ( 27670562 )
2016
15
Chylous ascites after resection of giant adrenocortical carcinoma. ( 28149812 )
2016
16
Multifocal Kaposiform Hemangioendothelioma Causing Massive Fetal Chylous Ascites. ( 27983885 )
2016
17
Therapeutic Application of Percutaneous Peritoneovenous (Denver) Shunt in Treating Chylous Ascites in Cancer Patients. ( 26965362 )
2016
18
Chylous Ascites Following Open Abdominal Aortic Aneurysm Repair: An Unusual Complication. ( 27486496 )
2016
19
The application of nutrition support in conservative treatment of chylous ascites after abdominal surgery. ( 27143902 )
2016
20
Chylous Ascites after Abdominal Aortic Aneurysm Repair. ( 27087873 )
2016
21
Transjugular Intrahepatic Portosystemic Shunt for the Treatment of Chylothorax and Chylous Ascites in Cirrhosis: A Case Report and Systematic Review of the Literature. ( 26723922 )
2016
22
Chylous Ascites in Advanced Gallbladder Cancer. ( 27994338 )
2016
23
Chylous ascites associated with intestinal obstruction from volvulus due to Petersen's hernia: report of a case. ( 27468960 )
2016
24
Successful management of chylous ascites: A report of two cases. ( 26997396 )
2016
25
Renal thrombotic microangiopathy, podocytopathy and chylous ascites: A hard-nosed diagnosis. ( 27154780 )
2016
26
Sirolimus Therapy for Patients With Lymphangioleiomyomatosis Leads to Loss of Chylous Ascites and Circulating LAM Cells. ( 27502989 )
2016
27
A 42-Year-Old Woman With Abnormal Chest CT Scan and Chylous Ascites. ( 26757302 )
2016
28
Chylous Ascites: A Rare Adverse Effect of Methimazole Treatment for Grave's Disease-A Case Report and Review of the Literature. ( 26366308 )
2015
29
Treatment options for chylous ascites after major abdominal surgery: a systematic review. ( 26117431 )
2015
30
Bilateral Cystic Lymphangioma of Ovary Associated with Chylous Ascites. ( 26435959 )
2015
31
Chylous ascites and lymphangiectasia in focal segmental glomerulosclerosis - a rare coexistence: a case report. ( 25880780 )
2015
32
Spontaneous chylous ascites, chylomediastinum and bilateral chylothoraces encountered during laparoscopic incarcerated paraesophageal hernia repair. ( 26506835 )
2015
33
Chylous ascites following retroperitoneal lymphadenectomy in gynecologic malignancies: Incidence, risk factors and management. ( 25765351 )
2015
34
Case report of chylous ascites with strangulated ileus and review of the literature. ( 26026475 )
2015
35
Chylous ascites treated by traditional Chinese herbal medicine: a case report and discussion. ( 25637154 )
2015
36
Incidence and risk factors of chylous ascites after pancreatic resection. ( 26064374 )
2015
37
Incidental Chylous Ascites at the Time of Cesarean Section. ( 26171264 )
2015
38
Acute chylous ascites mimicking appendicitis. ( 25682857 )
2015
39
Successful Minimally Invasive Treatment of Intractable, Postoperative Chylous Ascites Via Percutaneous Lymph Vessel Embolization. ( 25933643 )
2015
40
Surgical repair of intractable chylous ascites following laparoscopic anterior resection. ( 26019476 )
2015
41
Chylothorax and chylous ascites. Clinical utility of planar scintigraphy and tomographic imaging with SPECT/CT. ( 26183818 )
2015
42
Left paraduodenal hernia accompanying chylous ascites. ( 26576408 )
2015
43
Duodenal adenocarcinoma: A rare cause of chyloperitoneum (chylous ascites). ( 26837993 )
2015
44
Simultaneous chylothorax and chylous ascites in a patient with castration-resistant prostate cancer after docetaxel chemotherapy: An unusual manifestation. ( 25854536 )
2015
45
Peer review report 1 on "Chylous ascites following retroperitoneal lymphadenectomy in gynecologic malignancies: Incidence, risk factors and management". ( 26338619 )
2015
46
Rare case of concurrent severe chylous ascites after radical surgery for cervical cancer. ( 26189272 )
2015
47
Pathology in practice. Chylous ascites with secondary neutrophilic inflammation in a foal. ( 25835169 )
2015
48
Management Protocol for Chylous Ascites After Laparoscopic Nephrectomy. ( 26210005 )
2015
49
Small-volume chylous ascites after laparoscopic radical gastrectomy for gastric cancer: results from a large population-based sample. ( 25741151 )
2015
50
Early onset of tuberous sclerosis with chylous ascites: a case report. ( 25905086 )
2015

Variations for Ascites, Chylous

Expression for Ascites, Chylous

Search GEO for disease gene expression data for Ascites, Chylous.

Pathways for Ascites, Chylous

GO Terms for Ascites, Chylous

Sources for Ascites, Chylous

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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