MCID: ASC009
MIFTS: 37

Ascites, Chylous

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Ascites, Chylous

MalaCards integrated aliases for Ascites, Chylous:

Name: Ascites, Chylous 57
Chylous Ascites 75 53 59 72
Congenital Chylous Ascites 53 72
Ascites Chylous 55

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive


HPO:

32
ascites, chylous:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 57 208300
MESH via Orphanet 45 D002915
ICD10 via Orphanet 34 I89.8
UMLS via Orphanet 73 C0008732
Orphanet 59 ORPHA1160
MedGen 42 C0008732
UMLS 72 C0008732 C2930811

Summaries for Ascites, Chylous

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 1160DefinitionChylous ascites is a rare form of ascites caused by accumulation of lymph in the peritoneal cavity, usually due to intra-abdominal malignancy, liver cirrhosis or abdominal surgery complications, and present with painless but progressive abdominal distension, dyspnea and weight gain.Visit the Orphanet disease page for more resources.

MalaCards based summary : Ascites, Chylous, also known as chylous ascites, is related to hennekam syndrome and liver cirrhosis. An important gene associated with Ascites, Chylous is SST (Somatostatin). The drugs Doxycycline and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include liver, lymph node and heart, and related phenotypes are ascites and lymphedema

Wikipedia : 75 Ascites is the abnormal buildup of fluid in the abdomen. Technically, it is more than 25 mL of fluid in... more...

More information from OMIM: 208300

Related Diseases for Ascites, Chylous

Diseases related to Ascites, Chylous via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 277)
# Related Disease Score Top Affiliating Genes
1 hennekam syndrome 11.8
2 liver cirrhosis 10.6
3 aortic aneurysm 10.6
4 pancreatitis 10.6
5 aortic aneurysm, familial abdominal, 1 10.5
6 lymphangiectasis 10.5
7 portal hypertension 10.5
8 lymphedema 10.5
9 aneurysm 10.4
10 lymphangioleiomyomatosis 10.4
11 nephrotic syndrome 10.4
12 acute pancreatitis 10.4
13 appendicitis 10.4
14 systemic lupus erythematosus 10.3
15 inguinal hernia 10.3
16 protein-losing enteropathy 10.3
17 lymphangioma 10.3
18 lymphocele 10.3
19 intestinal volvulus 10.3
20 lupus erythematosus 10.3
21 rare lymphatic malformation 10.3
22 diarrhea 10.3
23 lymphopenia 10.3
24 acquired immunodeficiency syndrome 10.3
25 yellow nail syndrome 10.3
26 pancreatic cancer 10.3
27 wilms tumor 5 10.3
28 colorectal cancer 10.2
29 ovarian cancer 10.2
30 thrombophilia due to thrombin defect 10.2
31 lymphoma, hodgkin, classic 10.2
32 cervical cancer 10.2
33 lymphoma, non-hodgkin, familial 10.2
34 endometrial cancer 10.2
35 gastric cancer 10.2
36 follicular lymphoma 10.2
37 thrombosis 10.2
38 portal vein thrombosis 10.2
39 biliary atresia 10.2
40 lymphadenitis 10.2
41 testicular cancer 10.2
42 peritonitis 10.2
43 intestinal obstruction 10.2
44 lymphatic malformations 10.2
45 fibrosis of extraocular muscles, congenital, 1 10.1
46 renal cell carcinoma, nonpapillary 10.1
47 sarcoidosis 1 10.1
48 neuroblastoma 1 10.1
49 bile duct cysts 10.1
50 human immunodeficiency virus type 1 10.1

Graphical network of the top 20 diseases related to Ascites, Chylous:



Diseases related to Ascites, Chylous

Symptoms & Phenotypes for Ascites, Chylous

Human phenotypes related to Ascites, Chylous:

59 32 (show all 8)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ascites 59 32 hallmark (90%) Very frequent (99-80%) HP:0001541
2 lymphedema 59 32 hallmark (90%) Very frequent (99-80%) HP:0001004
3 subcutaneous nodule 59 32 frequent (33%) Frequent (79-30%) HP:0001482
4 neoplasm 59 32 occasional (7.5%) Occasional (29-5%) HP:0002664
5 pancreatitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001733
6 glaucoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0000501
7 abnormal intestine morphology 59 32 occasional (7.5%) Occasional (29-5%) HP:0002242
8 chylous ascites 32 HP:0012281

Symptoms via clinical synopsis from OMIM:

57
Abdomen:
chylous ascites, congenital

Eye:
bilateral glaucoma

Limbs:
arm swelling

Clinical features from OMIM:

208300

Drugs & Therapeutics for Ascites, Chylous

DrugBank drugs 16 :

# Drug Name Indication DrugBank ID
1 Isosulfan blue Isosulfan Blue is a synthetic visual lymphatic imaging agent. Isosulfan blue upon subcutaneous administration, delineates the lymphatic vessels draining the region of injection. It is an adjunct to lymphography in: primary and secondary lymphedema of the extremities; chyluria, chylous ascites or chylothorax; lymph node involvement by primary or secondary neoplasm; lymph node response to therapeutic modalities. DB09136

Drugs for Ascites, Chylous (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2 Anti-Bacterial Agents Phase 4
3 Antimalarials Phase 4
4 Antiparasitic Agents Phase 4
5 Antiprotozoal Agents Phase 4
6 Anti-Infective Agents Phase 4
7
Somatostatin Approved, Investigational Phase 2 38916-34-6, 51110-01-1 53481605
8
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
9
Pasireotide Approved Phase 2 396091-73-9 9941444
10 Gastrointestinal Agents Phase 2
11 Antineoplastic Agents, Hormonal Phase 2
12 Hormones Phase 2
13 Hormone Antagonists Phase 2
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
15
Pancrelipase Approved, Investigational 53608-75-6
16 Antihypertensive Agents
17 pancreatin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomised, Double Blind, Placebo Controlled Trial of Doxycycline in Lymphangioleiomyomatosis. Completed NCT00989742 Phase 4 Doxycycline;Placebo
2 Treatment With Octreotide in Patients With Lymphangioleiomyomatosis Completed NCT00005906 Phase 2 Octreotide
3 Evaluation of the Effect of Pasireotide LAR Administration in the Lymphocele Prevention After Axillary Node Dissection for Breast Cancer Completed NCT01356862 Phase 2 PASIREOTIDE;PLACEBO
4 The Role of Intravenous Albumin Replacement During Abdominal Paracentesis in Patients With Malignancy Related Ascites Unknown status NCT02811406
5 Near Infrared Fluorescent Technique for Sentinel Lymph Node Mapping in Endometrial Cancer Completed NCT02690259
6 Chyle Leak After Pancreatic Surgery - CLAP Recruiting NCT03079986
7 Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders Recruiting NCT02156115
8 Observational Study in Chyle Leak After Pancreatic Operation Not yet recruiting NCT03127150

Search NIH Clinical Center for Ascites, Chylous

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Isosulfan blue

Genetic Tests for Ascites, Chylous

Anatomical Context for Ascites, Chylous

MalaCards organs/tissues related to Ascites, Chylous:

41
Liver, Lymph Node, Heart, Lung, Breast, Pancreas, Testis

Publications for Ascites, Chylous

Articles related to Ascites, Chylous:

(show top 50) (show all 1186)
# Title Authors PMID Year
1
Chylous ascites in sibs from a consanguineous marriage. 38 8
474627 1979
2
Chylous ascites in siblings. 38 8
13011715 1953
3
Chylous ascites after excision of a choledochal cyst in a child. 9 38
19433158 2009
4
Chylous ascites after living related liver transplantation treated with somatostatin analog and parenteral nutrition. 9 38
18261617 2008
5
Successful management of chylous ascites after living donor liver transplantation with somatostatin. 9 38
18173563 2008
6
Successful management of chylous ascites with total parenteral nutrition, somatostatin, and fibrin glue. 9 38
18028785 2007
7
Octreotide therapy for chylous ascites in a chronic dialysis patient. 9 38
16109079 2005
8
[Treatment of congenital chylous ascites using total parenteral nutrition and somatostatin: a case report]. 9 38
15833179 2005
9
Resolution of refractory chylous ascites after Kasai portoenterostomy using octreotide. 9 38
15616936 2004
10
Chylous ascites: treated with total parenteral nutrition and somatostatin. 9 38
15300913 2004
11
Chylous ascites caused by portal vein thrombosis treated with octreotide. 9 38
12974913 2003
12
The diagnosis and management of postoperative chylous ascites. 9 38
11792897 2002
13
Rapid resolution of chylous ascites after liver transplantation using somatostatin analog and total parenteral nutrition. 9 38
8629307 1996
14
Diagnosis, Outcome, and Management of Chylous Ascites Following Pediatric Liver Transplantation. 38
31301267 2019
15
Back to the Future: Lipiodol in Lymphography-From Diagnostics to Theranostics. 38
31283538 2019
16
Characterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice. 38
31409739 2019
17
Intra-abdominal chylovenous bypass treats retroperitoneal lymphangiomatosis. 38
31273800 2019
18
Lymphangioleiomyomatosis manifesting as refractory chylothorax and chyloperitoneum. 38
31300601 2019
19
Hennekam syndrome: an uncommon cause of chylous ascites and intestinal lymphangiectasia in the tropics. 38
31326900 2019
20
Successful treatment of refractory chylous ascites due to follicular lymphoma with very low-dose radiotherapy. 38
31194016 2019
21
Simultaneous chylous ascites and chylothorax during ramucirumab plus docetaxel chemotherapy in a patient with non-small lung cell cancer. 38
31218186 2019
22
Heparin in Congenital Chylothorax and Chylous Ascites. 38
31012049 2019
23
Successful percutaneous embolization of refractory chylous ascites following peritoneal lymph node dissection. 38
30988860 2019
24
Sclerosing Mesenteritis. 38
30829677 2019
25
Interventional Treatment of Lymphatic Leakage Post Appendectomy: Case Report. 38
31198465 2019
26
Direct percutaneous embolization of intestinal lymphatic trunk for chylous ascites management following liver transplant. 38
30899336 2019
27
Val30Met Familial Amyloid Polyneuropathy, Heart Failure, and Chylous Ascites: An Unexpected Combination. 38
29880429 2019
28
3-Methylcholanthrene Induces Chylous Ascites in TCDD-Inducible Poly-ADP-Ribose Polymerase (Tiparp) Knockout Mice. 38
31083300 2019
29
Laparoscopic surgical repair of refractory chylous ascites after laparoscopic anterior resection. 38
30734160 2019
30
Percutaneous Balloon Plasty for Thoracic Duct Occlusion in a Patient with Chylothorax and Chylous Ascites. 38
30617452 2019
31
Low-Dose Radiation Therapy is an Effective Treatment for Refractory Postoperative Chylous Ascites: A Case Report. 38
30562613 2019
32
Surgical outcomes according to the type of monopolar electrocautery device used in laparoscopic surgery for right colon cancer: a comparison of endo-hook versus endo-shears. 38
31147824 2019
33
Milking the System: Dietary Therapy of Post-nephrectomy Chylous Ascites. 38
30949904 2019
34
Management of postoperative chylous ascites after surgery for ovarian cancer: a single-institution experience. 38
31006086 2019
35
Calcium Channel Blocker-Related Chylous Ascites: A Systematic Review and Meta-Analysis. 38
30959848 2019
36
Chylous Ascites: Complication of Laparoscopic Donor Nephrectomy. Case Report and Review of Literature. 38
30399121 2019
37
Pediatric chylous ascites treatment with combined ultrasound and fluoroscopy-guided intranodal lymphangiography. 38
31367098 2019
38
Clinical Profile, Response to Therapy, and Outcome of Children with Primary Intestinal Lymphangiectasia. 38
31030202 2019
39
Systemic Laparoscopic Para-Aortic Lymphadenectomy to the Left Renal Vein. 38
31223225 2019
40
Non-contrast MR lymphography of the lymphatic system of the liver. 38
30937582 2019
41
Transudative chylothorax associated with alcoholic cirrhosis. 38
30949356 2019
42
A Case of Idiopathic Chylous Ascites Simulating Rupture of Hemorrhagic Cyst in the Ovary. 38
29902596 2019
43
Retroperitoneal exploration with Vicryl mesh and fibrin tissue sealant for refractory chylous ascites. 38
30340876 2019
44
Chylous ascites following laparoscopic live donor nephrectomy: A new improved treatment paradigm. 38
30661276 2019
45
Chylous ascites in disseminated Kaposi sarcoma: an unusual manifestation as immune reconstitution inflammatory syndrome. 38
30904896 2019
46
Chylous ascites and podocytopathy as the presentation of childhood lupus-an unusual occurrence. 38
30526330 2019
47
Chylous ascites, anti-interferon-gamma autoantibody, and angioimmunoblastic T-cell lymphoma: a rare but intriguing connection over Mycobacterium avium. 38
30083859 2019
48
Combined Chylothorax and Chylous Ascites Complicating Liver Transplantation: A Report of a Case and Review of the Literature. 38
31428509 2019
49
Chylothorax secondary to a pleuroperitoneal communication and chylous ascites after pancreatic resection. 38
30697412 2019
50
Conservative management of chylous ascites after oncological surgery for peripheral neuroblastic tumors in pediatric patients. 38
31119912 2019

Variations for Ascites, Chylous

Expression for Ascites, Chylous

Search GEO for disease gene expression data for Ascites, Chylous.

Pathways for Ascites, Chylous

GO Terms for Ascites, Chylous

Sources for Ascites, Chylous

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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