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MCID: ASC009
MIFTS: 36

Ascites, Chylous

Categories: Rare diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Ascites, Chylous

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MalaCards integrated aliases for Ascites, Chylous:

Name: Ascites, Chylous 56
Chylous Ascites 74 52 58 71
Congenital Chylous Ascites 52 71
Ascites Chylous 54

Characteristics:

OMIM:

56
Inheritance:
autosomal recessive


HPO:

31
ascites, chylous:
Inheritance autosomal recessive inheritance


Classifications:

MalaCards categories:
Global: Rare diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

OMIM 56 208300
MESH via Orphanet 44 D002915
ICD10 via Orphanet 33 I89.8
UMLS via Orphanet 72 C0008732
Orphanet 58 ORPHA1160
MedGen 41 C0008732
UMLS 71 C0008732 C2930811
Sources

Summaries for Ascites, Chylous

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NIH Rare Diseases : 52 The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 1160 Definition Chylous ascites is a rare form of ascites caused by accumulation of lymph in the peritoneal cavity, usually due to intra-abdominal malignancy, liver cirrhosis or abdominal surgery complications, and present with painless but progressive abdominal distension, dyspnea and weight gain. Visit the Orphanet disease page for more resources.

MalaCards based summary : Ascites, Chylous, also known as chylous ascites, is related to hennekam syndrome and liver cirrhosis. An important gene associated with Ascites, Chylous is SST (Somatostatin). The drugs Doxycycline and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include liver, lymph node and heart, and related phenotypes are ascites and lymphedema

Wikipedia : 74 Ascites is the abnormal buildup of fluid in the abdomen. Technically, it is more than 25 ml of fluid in... more...

More information from OMIM: 208300
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Related Diseases for Ascites, Chylous

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Diseases related to Ascites, Chylous via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 273)
# Related Disease Score Top Affiliating Genes
1 hennekam syndrome 11.8
2 liver cirrhosis 10.6
3 aortic aneurysm 10.6
4 pancreatitis 10.6
5 aortic aneurysm, familial abdominal, 1 10.5
6 lymphangiectasis 10.5
7 lymphedema 10.5
8 portal hypertension 10.5
9 lymphangioma 10.4
10 lymphangioleiomyomatosis 10.4
11 acute pancreatitis 10.4
12 aneurysm 10.4
13 nephrotic syndrome 10.4
14 rare lymphatic malformation 10.4
15 adenocarcinoma 10.4
16 lupus erythematosus 10.4
17 systemic lupus erythematosus 10.3
18 volvulus of midgut 10.3
19 inguinal hernia 10.3
20 protein-losing enteropathy 10.3
21 lymphocele 10.3
22 lymphopenia 10.3
23 acquired immunodeficiency syndrome 10.3
24 colorectal cancer 10.3
25 yellow nail syndrome 10.3
26 thrombophilia due to thrombin defect 10.3
27 follicular lymphoma 10.3
28 peritonitis 10.3
29 ovarian cancer 10.2
30 lymphoma, hodgkin, classic 10.2
31 cervical cancer 10.2
32 lymphoma, non-hodgkin, familial 10.2
33 endometrial cancer 10.2
34 gastric cancer 10.2
35 portal vein thrombosis 10.2
36 biliary atresia 10.2
37 lymphadenitis 10.2
38 testicular cancer 10.2
39 intestinal obstruction 10.2
40 fibrosis of extraocular muscles, congenital, 1 10.1
41 renal cell carcinoma, nonpapillary 10.1
42 sarcoidosis 1 10.1
43 pancreatic cancer 10.1
44 bile duct cysts 10.1
45 human immunodeficiency virus type 1 10.1
46 membranous nephropathy 10.1
47 thrombosis 10.1
48 mesenteric lymphadenitis 10.1
49 filariasis 10.1
50 respiratory failure 10.1

Graphical network of the top 20 diseases related to Ascites, Chylous:



Diseases related to Ascites, Chylous
Sources

Symptoms & Phenotypes for Ascites, Chylous

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Human phenotypes related to Ascites, Chylous:

58 31 (show all 8)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ascites 58 31 hallmark (90%) Very frequent (99-80%) HP:0001541
2 lymphedema 58 31 hallmark (90%) Very frequent (99-80%) HP:0001004
3 subcutaneous nodule 58 31 frequent (33%) Frequent (79-30%) HP:0001482
4 neoplasm 58 31 occasional (7.5%) Occasional (29-5%) HP:0002664
5 pancreatitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001733
6 glaucoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0000501
7 abnormal intestine morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0002242
8 chylous ascites 31 HP:0012281

Symptoms via clinical synopsis from OMIM:

56
Abdomen:
chylous ascites, congenital

Eye:
bilateral glaucoma

Limbs:
arm swelling

Clinical features from OMIM:

208300
Sources

Drugs & Therapeutics for Ascites, Chylous

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Drugs for Ascites, Chylous (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2 Anti-Bacterial Agents Phase 4
3 Antimalarials Phase 4
4 Antiprotozoal Agents Phase 4
5 Antiparasitic Agents Phase 4
6 Anti-Infective Agents Phase 4
7
Somatostatin Approved, Investigational Phase 2 51110-01-1, 38916-34-6 53481605
8
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
9
Pasireotide Approved Phase 2 396091-73-9 9941444
10 Gastrointestinal Agents Phase 2
11 Antineoplastic Agents, Hormonal Phase 2
12 Hormone Antagonists Phase 2
13 Hormones Phase 2
14
Pancrelipase Approved, Investigational 53608-75-6
15 Antihypertensive Agents
16 pancreatin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomised, Double Blind, Placebo Controlled Trial of Doxycycline in Lymphangioleiomyomatosis. Completed NCT00989742 Phase 4 Doxycycline;Placebo
2 Treatment With Octreotide in Patients With Lymphangioleiomyomatosis Completed NCT00005906 Phase 2 Octreotide
3 Evaluation of the Effect of Pasireotide LAR Administration in the Lymphocele Prevention After Axillary Node Dissection for Breast Cancer Completed NCT01356862 Phase 2 PASIREOTIDE;PLACEBO
4 The Role of Intravenous Albumin Replacement During Abdominal Paracentesis in Patients With Malignancy Related Ascites Unknown status NCT02811406
5 Near Infrared Fluorescent Technique for Sentinel Lymph Node Mapping in Endometrial Cancer Completed NCT02690259
6 Chyle Leak After Pancreatic Surgery - CLAP Recruiting NCT03079986
7 Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders Recruiting NCT02156115
8 Observational Study in Chyle Leak After Pancreatic Operation Not yet recruiting NCT03127150

Search NIH Clinical Center for Ascites, Chylous

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Genetic Tests for Ascites, Chylous

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Anatomical Context for Ascites, Chylous

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MalaCards organs/tissues related to Ascites, Chylous:

40
Liver, Lymph Node, Heart, T Cells, Breast, Kidney, Pancreas
Sources

Publications for Ascites, Chylous

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Articles related to Ascites, Chylous:

(show top 50) (show all 1206)
# Title Authors PMID Year
1
Chylous ascites in sibs from a consanguineous marriage. 61 56
474627 1979
2
Chylous ascites in siblings. 61 56
13011715 1953
3
Chylous ascites after excision of a choledochal cyst in a child. 54 61
19433158 2009
4
Chylous ascites after living related liver transplantation treated with somatostatin analog and parenteral nutrition. 54 61
18261617 2008
5
Successful management of chylous ascites after living donor liver transplantation with somatostatin. 54 61
18173563 2008
6
Successful management of chylous ascites with total parenteral nutrition, somatostatin, and fibrin glue. 54 61
18028785 2007
7
Octreotide therapy for chylous ascites in a chronic dialysis patient. 54 61
16109079 2005
8
[Treatment of congenital chylous ascites using total parenteral nutrition and somatostatin: a case report]. 54 61
15833179 2005
9
Resolution of refractory chylous ascites after Kasai portoenterostomy using octreotide. 54 61
15616936 2004
10
Chylous ascites: treated with total parenteral nutrition and somatostatin. 54 61
15300913 2004
11
Chylous ascites caused by portal vein thrombosis treated with octreotide. 54 61
12974913 2003
12
The diagnosis and management of postoperative chylous ascites. 54 61
11792897 2002
13
Rapid resolution of chylous ascites after liver transplantation using somatostatin analog and total parenteral nutrition. 54 61
8629307 1996
14
Spontaneous Chylous Ascites After Liver Transplantation Secondary to Everolimus: A Case Report. 61
32029315 2020
15
Bilateral chylothorax and chylous ascites resulting from the spontaneous rupture of a retroperitoneal lymphangioma. 61
31987467 2020
16
Two Cases of Atraumatic Chylous Ascites Characterized by Hypotriglyceridemia and Partially Managed with an Oral Fat-Free Elemental Diet. 61
31970002 2020
17
Intra-abdominal chylovenous bypass treats retroperitoneal lymphangiomatosis. 61
31273800 2020
18
Chylous Ascites - Rare Manifestation of Lupus. 61
31979690 2020
19
Long-Term Outcomes of Surgical Treatment by In Situ Graft Reconstruction for Infected Abdominal Aortic Aneurysm. 61
31942212 2019
20
Management of postoperative chylous ascites after surgery for ovarian cancer: a single-institution experience. 61
31006086 2019
21
Chylothorax as a complication of extensive spontaneous left arm DVT. 61
31892625 2019
22
Cisterna chyli: An important landmark in laparoscopic paraaortic lymphadenectomy. 61
31892416 2019
23
Laparoscopic management of chylous ascites posthiatal hernia repair with Toupet fundoplication. 61
31793456 2019
24
White mesentery and chylous ascites: an interesting presentation of mesenteric lymphangioma. 61
31798825 2019
25
Resolution of Protein-Losing Enteropathy after Congenital Heart Disease Repair by Selective Lymphatic Embolization. 61
31777727 2019
26
Chylous Ascites. 61
31720957 2019
27
Non-contrast MR lymphography of the lymphatic system of the liver. 61
30937582 2019
28
Management of chylous ascites following pancreaticobiliary surgery. 61
31633049 2019
29
An Unusual Combination of Three Rare Complications: Pleuro-Pancreatic Fistula, Chylous Ascites, and Renal Vein Thrombosis, in a Case of Acute Severe Pancreatitis. 61
31763461 2019
30
Characterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice. 61
31409739 2019
31
A Massive Chylous Ascites With Severe Morbidity After Laparoscopic Donor Nephrectomy and Successful Treatment With Total Parenteral Nutrition and Octreotide. 61
31615378 2019
32
Novel Technique to Manage Refractory Chylous Ascites with Carbon Nanoparticle Suspension in Infants. 61
31679773 2019
33
First Case of Chylous Ascites after Laparoscopic Myomectomy: A Case Report with a Literature Review. 61
31547593 2019
34
Diagnosis, Outcome, and Management of Chylous Ascites Following Pediatric Liver Transplantation. 61
31301267 2019
35
Back to the Future: Lipiodol in Lymphography-From Diagnostics to Theranostics. 61
31283538 2019
36
Chylous Ascites Developing after Open Thoracoabdominal Aortic Aneurysm Repair in a Patient with Marfan Syndrome. 61
31478365 2019
37
Chylous Ascites Accompanying Internal Hernia after Total Gastrectomy with Roux-en-Y Reconstruction. 61
31824237 2019
38
A case of follicular lymphoma accompanied with chylous ascites. 61
31730681 2019
39
Chylous ascites during peritoneal dialysisin a toddler: a rare complication. 61
31439572 2019
40
Heparin in Congenital Chylothorax and Chylous Ascites. 61
31012049 2019
41
Lymphangioleiomyomatosis manifesting as refractory chylothorax and chyloperitoneum. 61
31300601 2019
42
Simultaneous chylous ascites and chylothorax during ramucirumab plus docetaxel chemotherapy in a patient with non-small lung cell cancer. 61
31218186 2019
43
Hennekam syndrome: an uncommon cause of chylous ascites and intestinal lymphangiectasia in the tropics. 61
31326900 2019
44
Successful treatment of refractory chylous ascites due to follicular lymphoma with very low-dose radiotherapy. 61
31194016 2019
45
Successful percutaneous embolization of refractory chylous ascites following peritoneal lymph node dissection. 61
30988860 2019
46
Sclerosing Mesenteritis. 61
30829677 2019
47
Interventional Treatment of Lymphatic Leakage Post Appendectomy: Case Report. 61
31198465 2019
48
Direct percutaneous embolization of intestinal lymphatic trunk for chylous ascites management following liver transplant. 61
30899336 2019
49
Laparoscopic surgical repair of refractory chylous ascites after laparoscopic anterior resection. 61
30734160 2019
50
Percutaneous Balloon Plasty for Thoracic Duct Occlusion in a Patient with Chylothorax and Chylous Ascites. 61
30617452 2019
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Variations for Ascites, Chylous

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Expression for Ascites, Chylous

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Search GEO for disease gene expression data for Ascites, Chylous.
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Pathways for Ascites, Chylous

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GO Terms for Ascites, Chylous

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Sources for Ascites, Chylous

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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