MCID: ASC009
MIFTS: 37

Ascites, Chylous

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Ascites, Chylous

MalaCards integrated aliases for Ascites, Chylous:

Name: Ascites, Chylous 56
Chylous Ascites 74 52 58 71
Congenital Chylous Ascites 52 71
Ascites Chylous 54

Characteristics:

OMIM:

56
Inheritance:
autosomal recessive


HPO:

31
ascites, chylous:
Inheritance autosomal recessive inheritance


Classifications:

Orphanet: 58  
Rare circulatory system diseases
Developmental anomalies during embryogenesis


External Ids:

OMIM 56 208300
MESH via Orphanet 44 D002915
ICD10 via Orphanet 33 I89.8
UMLS via Orphanet 72 C0008732
Orphanet 58 ORPHA1160
MedGen 41 C0008732
UMLS 71 C0008732 C2930811

Summaries for Ascites, Chylous

NIH Rare Diseases : 52 The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 1160 Definition Chylous ascites is a rare form of ascites caused by accumulation of lymph in the peritoneal cavity, usually due to intra-abdominal malignancy, liver cirrhosis or abdominal surgery complications, and present with painless but progressive abdominal distension, dyspnea and weight gain. Visit the Orphanet disease page for more resources.

MalaCards based summary : Ascites, Chylous, also known as chylous ascites, is related to hennekam syndrome and aortic aneurysm. An important gene associated with Ascites, Chylous is SST (Somatostatin). The drugs Doxycycline and Antimalarials have been mentioned in the context of this disorder. Affiliated tissues include liver, lymph node and heart, and related phenotypes are ascites and lymphedema

Wikipedia : 74 Ascites is the abnormal buildup of fluid in the abdomen. Technically, it is more than 25 ml of fluid in... more...

More information from OMIM: 208300

Related Diseases for Ascites, Chylous

Diseases related to Ascites, Chylous via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 273)
# Related Disease Score Top Affiliating Genes
1 hennekam syndrome 11.8
2 aortic aneurysm 10.6
3 pancreatitis 10.6
4 aortic aneurysm, familial abdominal, 1 10.5
5 lymphangiectasis 10.5
6 portal hypertension 10.5
7 lymphedema 10.5
8 aneurysm 10.4
9 lymphangioleiomyomatosis 10.4
10 lymphangioma 10.4
11 acute pancreatitis 10.4
12 nephrotic syndrome 10.4
13 appendicitis 10.4
14 rare lymphatic malformation 10.4
15 systemic lupus erythematosus 10.3
16 inguinal hernia 10.3
17 protein-losing enteropathy 10.3
18 lymphocele 10.3
19 intestinal volvulus 10.3
20 lupus erythematosus 10.3
21 lymphopenia 10.3
22 acquired immunodeficiency syndrome 10.3
23 colorectal cancer 10.3
24 yellow nail syndrome 10.3
25 thrombophilia due to thrombin defect 10.3
26 follicular lymphoma 10.3
27 ovarian cancer 10.2
28 lymphoma, hodgkin, classic 10.2
29 cervical cancer 10.2
30 lymphoma, non-hodgkin, familial 10.2
31 gastric cancer 10.2
32 portal vein thrombosis 10.2
33 biliary atresia 10.2
34 lymphadenitis 10.2
35 testicular cancer 10.2
36 intestinal obstruction 10.2
37 fibrosis of extraocular muscles, congenital, 1 10.1
38 renal cell carcinoma, nonpapillary 10.1
39 sarcoidosis 1 10.1
40 pancreatic cancer 10.1
41 bile duct cysts 10.1
42 human immunodeficiency virus type 1 10.1
43 membranous nephropathy 10.1
44 thrombosis 10.1
45 mesenteric lymphadenitis 10.1
46 filariasis 10.1
47 respiratory failure 10.1
48 hemopericardium 10.1
49 pericardial effusion 10.1
50 focal segmental glomerulosclerosis 10.1

Graphical network of the top 20 diseases related to Ascites, Chylous:



Diseases related to Ascites, Chylous

Symptoms & Phenotypes for Ascites, Chylous

Human phenotypes related to Ascites, Chylous:

58 31 (show all 8)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ascites 58 31 hallmark (90%) Very frequent (99-80%) HP:0001541
2 lymphedema 58 31 hallmark (90%) Very frequent (99-80%) HP:0001004
3 subcutaneous nodule 58 31 frequent (33%) Frequent (79-30%) HP:0001482
4 neoplasm 58 31 occasional (7.5%) Occasional (29-5%) HP:0002664
5 pancreatitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001733
6 glaucoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0000501
7 abnormal intestine morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0002242
8 chylous ascites 31 HP:0012281

Symptoms via clinical synopsis from OMIM:

56
Abdomen:
chylous ascites, congenital

Eye:
bilateral glaucoma

Limbs:
arm swelling

Clinical features from OMIM:

208300

Drugs & Therapeutics for Ascites, Chylous

Drugs for Ascites, Chylous (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2 Antimalarials Phase 4
3 Anti-Bacterial Agents Phase 4
4 Anti-Infective Agents Phase 4
5 Antiparasitic Agents Phase 4
6 Antiprotozoal Agents Phase 4
7
Octreotide Approved, Investigational Phase 2 83150-76-9 6400441 383414
8
Somatostatin Approved, Investigational Phase 2 51110-01-1, 38916-34-6 53481605
9
Pasireotide Approved Phase 2 396091-73-9 9941444
10 Gastrointestinal Agents Phase 2
11 Antineoplastic Agents, Hormonal Phase 2
12 Hormone Antagonists Phase 2
13 Hormones Phase 2
14
Pancrelipase Approved, Investigational 53608-75-6
15 Antihypertensive Agents
16 pancreatin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomised, Double Blind, Placebo Controlled Trial of Doxycycline in Lymphangioleiomyomatosis. Completed NCT00989742 Phase 4 Doxycycline;Placebo
2 Treatment With Octreotide in Patients With Lymphangioleiomyomatosis Completed NCT00005906 Phase 2 Octreotide
3 Evaluation of the Effect of Pasireotide LAR Administration in the Lymphocele Prevention After Axillary Node Dissection for Breast Cancer Completed NCT01356862 Phase 2 PASIREOTIDE;PLACEBO
4 The Role of Intravenous Albumin Replacement During Abdominal Paracentesis in Patients With Malignancy Related Ascites Unknown status NCT02811406
5 Near Infrared Fluorescent Technique for Sentinel Lymph Node Mapping in Endometrial Cancer Completed NCT02690259
6 Chyle Leak After Pancreatic Surgery - CLAP Recruiting NCT03079986
7 Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders Recruiting NCT02156115
8 Observational Study in Chyle Leak After Pancreatic Operation Not yet recruiting NCT03127150

Search NIH Clinical Center for Ascites, Chylous

Genetic Tests for Ascites, Chylous

Anatomical Context for Ascites, Chylous

MalaCards organs/tissues related to Ascites, Chylous:

40
Liver, Lymph Node, Heart, Breast, Lung, Pancreas, Testis

Publications for Ascites, Chylous

Articles related to Ascites, Chylous:

(show top 50) (show all 1199)
# Title Authors PMID Year
1
Chylous ascites in sibs from a consanguineous marriage. 56 61
474627 1979
2
Chylous ascites in siblings. 56 61
13011715 1953
3
Chylous ascites after excision of a choledochal cyst in a child. 61 54
19433158 2009
4
Chylous ascites after living related liver transplantation treated with somatostatin analog and parenteral nutrition. 61 54
18261617 2008
5
Successful management of chylous ascites after living donor liver transplantation with somatostatin. 61 54
18173563 2008
6
Successful management of chylous ascites with total parenteral nutrition, somatostatin, and fibrin glue. 61 54
18028785 2007
7
Octreotide therapy for chylous ascites in a chronic dialysis patient. 61 54
16109079 2005
8
[Treatment of congenital chylous ascites using total parenteral nutrition and somatostatin: a case report]. 54 61
15833179 2005
9
Resolution of refractory chylous ascites after Kasai portoenterostomy using octreotide. 61 54
15616936 2004
10
Chylous ascites: treated with total parenteral nutrition and somatostatin. 61 54
15300913 2004
11
Chylous ascites caused by portal vein thrombosis treated with octreotide. 61 54
12974913 2003
12
The diagnosis and management of postoperative chylous ascites. 54 61
11792897 2002
13
Rapid resolution of chylous ascites after liver transplantation using somatostatin analog and total parenteral nutrition. 54 61
8629307 1996
14
Laparoscopic management of chylous ascites posthiatal hernia repair with Toupet fundoplication. 61
31793456 2019
15
Management of postoperative chylous ascites after surgery for ovarian cancer: a single-institution experience. 61
31006086 2019
16
Chylous Ascites. 61
31720957 2019
17
White mesentery and chylous ascites: an interesting presentation of mesenteric lymphangioma. 61
31798825 2019
18
Resolution of Protein-Losing Enteropathy after Congenital Heart Disease Repair by Selective Lymphatic Embolization. 61
31777727 2019
19
Non-contrast MR lymphography of the lymphatic system of the liver. 61
30937582 2019
20
Characterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice. 61
31409739 2019
21
Novel Technique to Manage Refractory Chylous Ascites with Carbon Nanoparticle Suspension in Infants. 61
31679773 2019
22
A Massive Chylous Ascites With Severe Morbidity After Laparoscopic Donor Nephrectomy and Successful Treatment With Total Parenteral Nutrition and Octreotide. 61
31615378 2019
23
Management of chylous ascites following pancreaticobiliary surgery. 61
31633049 2019
24
An Unusual Combination of Three Rare Complications: Pleuro-Pancreatic Fistula, Chylous Ascites, and Renal Vein Thrombosis, in a Case of Acute Severe Pancreatitis. 61
31763461 2019
25
Chylous Ascites Developing after Open Thoracoabdominal Aortic Aneurysm Repair in a Patient with Marfan Syndrome. 61
31478365 2019
26
Chylous Ascites Accompanying Internal Hernia after Total Gastrectomy with Roux-en-Y Reconstruction. 61
31824237 2019
27
A case of follicular lymphoma accompanied with chylous ascites. 61
31730681 2019
28
Diagnosis, Outcome, and Management of Chylous Ascites Following Pediatric Liver Transplantation. 61
31301267 2019
29
First Case of Chylous Ascites after Laparoscopic Myomectomy: A Case Report with a Literature Review. 61
31547593 2019
30
Back to the Future: Lipiodol in Lymphography-From Diagnostics to Theranostics. 61
31283538 2019
31
Chylous ascites during peritoneal dialysisin a toddler: a rare complication. 61
31439572 2019
32
Heparin in Congenital Chylothorax and Chylous Ascites. 61
31012049 2019
33
Lymphangioleiomyomatosis manifesting as refractory chylothorax and chyloperitoneum. 61
31300601 2019
34
Intra-abdominal chylovenous bypass treats retroperitoneal lymphangiomatosis. 61
31273800 2019
35
Successful treatment of refractory chylous ascites due to follicular lymphoma with very low-dose radiotherapy. 61
31194016 2019
36
Hennekam syndrome: an uncommon cause of chylous ascites and intestinal lymphangiectasia in the tropics. 61
31326900 2019
37
Simultaneous chylous ascites and chylothorax during ramucirumab plus docetaxel chemotherapy in a patient with non-small lung cell cancer. 61
31218186 2019
38
Successful percutaneous embolization of refractory chylous ascites following peritoneal lymph node dissection. 61
30988860 2019
39
Sclerosing Mesenteritis. 61
30829677 2019
40
Interventional Treatment of Lymphatic Leakage Post Appendectomy: Case Report. 61
31198465 2019
41
Direct percutaneous embolization of intestinal lymphatic trunk for chylous ascites management following liver transplant. 61
30899336 2019
42
3-Methylcholanthrene Induces Chylous Ascites in TCDD-Inducible Poly-ADP-Ribose Polymerase (Tiparp) Knockout Mice. 61
31083300 2019
43
Low-Dose Radiation Therapy is an Effective Treatment for Refractory Postoperative Chylous Ascites: A Case Report. 61
30562613 2019
44
Percutaneous Balloon Plasty for Thoracic Duct Occlusion in a Patient with Chylothorax and Chylous Ascites. 61
30617452 2019
45
Laparoscopic surgical repair of refractory chylous ascites after laparoscopic anterior resection. 61
30734160 2019
46
Val30Met Familial Amyloid Polyneuropathy, Heart Failure, and Chylous Ascites: An Unexpected Combination. 61
29880429 2019
47
Surgical outcomes according to the type of monopolar electrocautery device used in laparoscopic surgery for right colon cancer: a comparison of endo-hook versus endo-shears. 61
31147824 2019
48
Milking the System: Dietary Therapy of Post-nephrectomy Chylous Ascites. 61
30949904 2019
49
Pediatric chylous ascites treatment with combined ultrasound and fluoroscopy-guided intranodal lymphangiography. 61
31367098 2019
50
Calcium Channel Blocker-Related Chylous Ascites: A Systematic Review and Meta-Analysis. 61
30959848 2019

Variations for Ascites, Chylous

Expression for Ascites, Chylous

Search GEO for disease gene expression data for Ascites, Chylous.

Pathways for Ascites, Chylous

GO Terms for Ascites, Chylous

Sources for Ascites, Chylous

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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