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MCID: ASC009
MIFTS: 35

Ascites, Chylous

Categories: Rare diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Ascites, Chylous

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MalaCards integrated aliases for Ascites, Chylous:

Name: Ascites, Chylous 56
Chylous Ascites 74 52 58 71
Congenital Chylous Ascites 52 71
Ascites Chylous 54

Characteristics:

OMIM:

56
Inheritance:
autosomal recessive


HPO:

31
ascites, chylous:
Inheritance autosomal recessive inheritance


Classifications:

MalaCards categories:
Global: Rare diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

OMIM 56 208300
MESH via Orphanet 44 D002915
ICD10 via Orphanet 33 I89.8
UMLS via Orphanet 72 C0008732
Orphanet 58 ORPHA1160
MedGen 41 C0008732
UMLS 71 C0008732 C2930811
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Summaries for Ascites, Chylous

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NIH Rare Diseases : 52 The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 1160 Definition Chylous ascites is a rare form of ascites caused by accumulation of lymph in the peritoneal cavity, usually due to intra-abdominal malignancy, liver cirrhosis or abdominal surgery complications, and present with painless but progressive abdominal distension, dyspnea and weight gain. Visit the Orphanet disease page for more resources.

MalaCards based summary : Ascites, Chylous, also known as chylous ascites, is related to hennekam syndrome and aortic aneurysm. An important gene associated with Ascites, Chylous is SST (Somatostatin). The drugs Doxycycline and Antiparasitic Agents have been mentioned in the context of this disorder. Affiliated tissues include liver, lymph node and heart, and related phenotypes are lymphedema and ascites

Wikipedia : 74 Ascites is the abnormal buildup of fluid in the abdomen. Technically, it is more than 25 ml of fluid in... more...

More information from OMIM: 208300
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Related Diseases for Ascites, Chylous

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Diseases related to Ascites, Chylous via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 267)
# Related Disease Score Top Affiliating Genes
1 hennekam syndrome 11.8
2 aortic aneurysm 10.6
3 aortic aneurysm, familial abdominal, 1 10.6
4 lymphangiectasis 10.5
5 hereditary lymphedema i 10.5
6 portal hypertension 10.5
7 lymphangioma 10.5
8 lymphangioleiomyomatosis 10.4
9 acute pancreatitis 10.4
10 aneurysm 10.4
11 nephrotic syndrome 10.4
12 rare lymphatic malformation 10.4
13 protein-losing enteropathy 10.4
14 lupus erythematosus 10.4
15 systemic lupus erythematosus 10.3
16 inguinal hernia 10.3
17 adenocarcinoma 10.3
18 lymphocele 10.3
19 lymphopenia 10.3
20 acquired immunodeficiency syndrome 10.3
21 colorectal cancer 10.3
22 yellow nail syndrome 10.3
23 thrombophilia due to thrombin defect 10.3
24 follicular lymphoma 10.3
25 testicular cancer 10.3
26 ovarian cancer 10.2
27 lymphoma, hodgkin, classic 10.2
28 cervical cancer 10.2
29 lymphoma, non-hodgkin, familial 10.2
30 gastric cancer 10.2
31 portal vein thrombosis 10.2
32 biliary atresia 10.2
33 lymphadenitis 10.2
34 neuroblastoma 10.2
35 intestinal obstruction 10.2
36 fibrosis of extraocular muscles, congenital, 1 10.1
37 renal cell carcinoma, nonpapillary 10.1
38 sarcoidosis 1 10.1
39 pancreatic cancer 10.1
40 bile duct cysts 10.1
41 human immunodeficiency virus type 1 10.1
42 membranous nephropathy 10.1
43 thrombosis 10.1
44 mesenteric lymphadenitis 10.1
45 filariasis 10.1
46 respiratory failure 10.1
47 hemopericardium 10.1
48 pericardial effusion 10.1
49 focal segmental glomerulosclerosis 10.1
50 rectum cancer 10.1

Graphical network of the top 20 diseases related to Ascites, Chylous:



Diseases related to Ascites, Chylous
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Symptoms & Phenotypes for Ascites, Chylous

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Human phenotypes related to Ascites, Chylous:

58 31 (show all 8)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 lymphedema 58 31 hallmark (90%) Very frequent (99-80%) HP:0001004
2 ascites 58 31 hallmark (90%) Very frequent (99-80%) HP:0001541
3 subcutaneous nodule 58 31 frequent (33%) Frequent (79-30%) HP:0001482
4 glaucoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0000501
5 neoplasm 58 31 occasional (7.5%) Occasional (29-5%) HP:0002664
6 pancreatitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001733
7 abnormal intestine morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0002242
8 chylous ascites 31 HP:0012281

Symptoms via clinical synopsis from OMIM:

56
Abdomen:
chylous ascites, congenital

Eye:
bilateral glaucoma

Limbs:
arm swelling

Clinical features from OMIM:

208300
Sources

Drugs & Therapeutics for Ascites, Chylous

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Drugs for Ascites, Chylous (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2 Antiparasitic Agents Phase 4
3 Anti-Bacterial Agents Phase 4
4 Antiprotozoal Agents Phase 4
5 Antimalarials Phase 4
6 Anti-Infective Agents Phase 4
7
Somatostatin Approved, Investigational Phase 2 38916-34-6, 51110-01-1 53481605
8
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
9
Pasireotide Approved Phase 2 396091-73-9 9941444
10 Antineoplastic Agents, Hormonal Phase 2
11 Gastrointestinal Agents Phase 2
12 Hormone Antagonists Phase 2
13 Hormones Phase 2
14
Pancrelipase Approved, Investigational 53608-75-6
15 Antihypertensive Agents
16 pancreatin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomised, Double Blind, Placebo Controlled Trial of Doxycycline in Lymphangioleiomyomatosis. Completed NCT00989742 Phase 4 Doxycycline;Placebo
2 Treatment With Octreotide in Patients With Lymphangioleiomyomatosis Completed NCT00005906 Phase 2 Octreotide
3 Evaluation of the Effect of Pasireotide LAR Administration in the Lymphocele Prevention After Axillary Node Dissection for Breast Cancer Completed NCT01356862 Phase 2 PASIREOTIDE;PLACEBO
4 The Role of Intravenous Albumin Replacement During Abdominal Paracentesis in Patients With Malignancy Related Ascites Unknown status NCT02811406
5 Near Infrared Fluorescent Technique for Sentinel Lymph Node Mapping in Endometrial Cancer Completed NCT02690259
6 Chyle Leak After Pancreatic Surgery - CLAP Recruiting NCT03079986
7 Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders Recruiting NCT02156115
8 Observational Study in Chyle Leak After Pancreatic Operation Not yet recruiting NCT03127150

Search NIH Clinical Center for Ascites, Chylous

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Genetic Tests for Ascites, Chylous

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Anatomical Context for Ascites, Chylous

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MalaCards organs/tissues related to Ascites, Chylous:

40
Liver, Lymph Node, Heart, Lung, Breast, Pancreas, Testis
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Publications for Ascites, Chylous

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Articles related to Ascites, Chylous:

(show top 50) (show all 1231)
# Title Authors PMID Year
1
Chylous ascites in sibs from a consanguineous marriage. 61 56
474627 1979
2
Chylous ascites in siblings. 61 56
13011715 1953
3
Chylous ascites after excision of a choledochal cyst in a child. 61 54
19433158 2009
4
Chylous ascites after living related liver transplantation treated with somatostatin analog and parenteral nutrition. 54 61
18261617 2008
5
Successful management of chylous ascites after living donor liver transplantation with somatostatin. 61 54
18173563 2008
6
Successful management of chylous ascites with total parenteral nutrition, somatostatin, and fibrin glue. 54 61
18028785 2007
7
Octreotide therapy for chylous ascites in a chronic dialysis patient. 54 61
16109079 2005
8
[Treatment of congenital chylous ascites using total parenteral nutrition and somatostatin: a case report]. 61 54
15833179 2005
9
Resolution of refractory chylous ascites after Kasai portoenterostomy using octreotide. 54 61
15616936 2004
10
Chylous ascites: treated with total parenteral nutrition and somatostatin. 54 61
15300913 2004
11
Chylous ascites caused by portal vein thrombosis treated with octreotide. 61 54
12974913 2003
12
The diagnosis and management of postoperative chylous ascites. 61 54
11792897 2002
13
Rapid resolution of chylous ascites after liver transplantation using somatostatin analog and total parenteral nutrition. 61 54
8629307 1996
14
Chylous ascites following a right robotic assissted laparoscopic partial nephrectomy. 61
32346515 2020
15
Endolymphatic exclusion for the treatment of pediatric chylous ascites secondary to neuroblastoma resection: report of two cases. 61
32461775 2020
16
Successful use of intraoperative ICG fluorescence lymphography and fibrin sealant with PGA felt for refractory chylous ascites in an infant: a novel procedure. 61
32524702 2020
17
Primary robotic retroperitoneal lymph node dissection following orchiectomy for testicular germ cell tumors: a single-surgeon experience. 61
32572754 2020
18
Successful treatment of large abdominal lymphatic malformations and chylous ascites with intra-abdominal lymphovenous anastomosis. 61
32505686 2020
19
A Single-Center Experience With Percutaneous Interventional Management of Refractory Chylous Ascites. 61
32510979 2020
20
Chylous Ascites Post Laparoscopic Sleeve Gastrectomy: Video Case Report of a Rare Complication. 61
32180114 2020
21
Simplified method to quantify valve back-leak uncovers severe mesenteric lymphatic valve dysfunction in mice deficient in connexins 43 and 37. 61
32267537 2020
22
Minimally Invasive Surgery Is Feasible in Patients with Liver and Kidney Transplantation. 61
32541640 2020
23
Refractory chylothorax and chylous ascites as form of presentation of diffuse lymphangiomatosis. 61
32446681 2020
24
Lymphangiography with or without Embolization for the Treatment of Postoperative Chylous Ascites. 61
32439520 2020
25
Chylous ascites as a late complication of one anastomosis gastric bypass-minigastric bypass: case report. 61
32375726 2020
26
Experience With 15 Years of Laparoscopic Donor Nephrectomy: Review of 2500 Cases. 61
32448655 2020
27
[Diagnosis and treatment of rare complications of liver cirrhosis]. 61
32536050 2020
28
Treatment of Chylous Ascites with Peritoneovenous Shunt (Denver Shunt) following Retroperitoneal Lymph Node Dissection in Patients with Urologic Malignancies: Update of Efficacy and Predictors of Complications. 61
32364837 2020
29
Chylous Ascites. 61
31720957 2020
30
Contrast-enhanced Interstitial Transpedal MR Lymphangiography for Thoracic Chylous Effusions. 61
32208098 2020
31
High-output chyloperitoneum following laparoscopic Nissen fundoplication treated with retrograde transvenous thoracic duct embolization. 61
32249340 2020
32
Novel technique to manage refractory chylous ascites with carbon nanoparticle suspension in infants. 61
31679773 2020
33
Successful Conversion Surgery Following Chylous Ascites After Nivolumab for Advanced Gastric Cancer. 61
32111756 2020
34
Spontaneous Chylous Ascites After Liver Transplantation Secondary to Everolimus: A Case Report. 61
32029315 2020
35
Surgical outcomes according to the type of monopolar electrocautery device used in laparoscopic surgery for right colon cancer: a comparison of endo-hook versus endo-shears. 61
31147824 2020
36
Conventional Lymphangiography (CL) in the Management of Postoperative Lymphatic Leakage (PLL): A Systematic Review. 61
32215900 2020
37
Successful management of chylous ascites after pancreatoduodenectomy using etilefrine: a case report. 61
32128220 2020
38
Cisterna chyli: An important landmark in laparoscopic paraaortic lymphadenectomy. 61
31892416 2020
39
Intra-abdominal chylovenous bypass treats retroperitoneal lymphangiomatosis. 61
31273800 2020
40
Refractory chylous effusions in lymphangioleiomyomatosis patient post lung transplant. 61
32477564 2020
41
Contemporary lymphatic interventions for post-operative lymphatic leaks. 61
32055491 2020
42
Two Cases of Atraumatic Chylous Ascites Characterized by Hypotriglyceridemia and Partially Managed with an Oral Fat-Free Elemental Diet. 61
31970002 2020
43
The Use of Indocyanin Green for Peroperative Diagnostic of Chylous Ascites and Autologous Tissue Glue (Vivostat) for the Treatment. 61
32303135 2020
44
Bilateral chylothorax and chylous ascites resulting from the spontaneous rupture of a retroperitoneal lymphangioma. 61
31987467 2020
45
Large pancreatic mass with chylous ascites. 61
32063769 2020
46
Chylous Ascites - Rare Manifestation of Lupus. 61
31979690 2020
47
Long-Term Outcomes of Surgical Treatment by In Situ Graft Reconstruction for Infected Abdominal Aortic Aneurysm. 61
31942212 2019
48
Management of postoperative chylous ascites after surgery for ovarian cancer: a single-institution experience. 61
31006086 2019
49
Laparoscopic management of chylous ascites posthiatal hernia repair with Toupet fundoplication. 61
31793456 2019
50
Chylothorax as a complication of extensive spontaneous left arm DVT. 61
31892625 2019
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Variations for Ascites, Chylous

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Expression for Ascites, Chylous

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Search GEO for disease gene expression data for Ascites, Chylous.
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Pathways for Ascites, Chylous

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GO Terms for Ascites, Chylous

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Sources for Ascites, Chylous

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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