MCID: ASC009
MIFTS: 41

Ascites, Chylous

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Ascites, Chylous

MalaCards integrated aliases for Ascites, Chylous:

Name: Ascites, Chylous 57
Chylous Ascites 76 53 59 73
Congenital Chylous Ascites 53 73
Ascites Chylous 55

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive


HPO:

32
ascites, chylous:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 57 208300
Orphanet 59 ORPHA1160
ICD10 via Orphanet 34 I89.8
MESH via Orphanet 45 D002915
UMLS via Orphanet 74 C0008732
MedGen 42 C0008732

Summaries for Ascites, Chylous

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 1160Disease definitionChylous ascites is a rare form of ascites caused by accumulation of lymph in the peritoneal cavity, usually due to intra-abdominal malignancy, liver cirrhosis or abdominal surgery complications, and present with painless but progressive abdominal distension, dyspnea and weight gain.Visit the Orphanet disease page for more resources.

MalaCards based summary : Ascites, Chylous, also known as chylous ascites, is related to pancreatitis and aortic aneurysm, familial abdominal, 1. An important gene associated with Ascites, Chylous is SST (Somatostatin). The drugs Somatostatin and Octreotide have been mentioned in the context of this disorder. Affiliated tissues include liver, lymph node and breast, and related phenotypes are subcutaneous nodule and ascites

Wikipedia : 76 Ascites is the abnormal buildup of fluid in the abdomen. Technically, it is more than 25 mL of fluid in... more...

Description from OMIM: 208300

Related Diseases for Ascites, Chylous

Diseases related to Ascites, Chylous via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Related Disease Score Top Affiliating Genes
1 pancreatitis 10.5
2 aortic aneurysm, familial abdominal, 1 10.4
3 aortic aneurysm 10.4
4 lymphoma 10.4
5 pericarditis 10.4
6 constrictive pericarditis 10.3
7 peritonitis 10.3
8 thrombosis 10.3
9 lymphangioleiomyomatosis 10.3
10 nephrotic syndrome 10.3
11 acute pancreatitis 10.3
12 adenocarcinoma 10.3
13 liver cirrhosis 10.2
14 lymphedema 10.2
15 lupus erythematosus 10.2
16 colorectal cancer 10.2
17 systemic lupus erythematosus 10.2
18 yellow nail syndrome 10.2
19 gastroschisis 10.2
20 lymphangioma 10.2
21 appendicitis 10.2
22 carcinoid syndrome 10.2
23 ovarian cancer 10.1
24 bile duct cysts 10.1
25 focal segmental glomerulosclerosis 1 10.1
26 wilms tumor 6 10.1
27 focal segmental glomerulosclerosis 10.1
28 leukemia 10.1
29 inguinal hernia 10.1
30 portal vein thrombosis 10.1
31 thrombophilia due to thrombin defect 10.0
32 cervical cancer 10.0
33 gastric cancer 10.0
34 membranous nephropathy 10.0
35 cholangiocarcinoma 10.0
36 morbid obesity 10.0
37 angioimmunoblastic t-cell lymphoma 10.0
38 protein-losing enteropathy 10.0
39 portal hypertension 10.0
40 mesenteric lymphadenitis 10.0
41 graves' disease 10.0
42 diarrhea 10.0
43 lymphadenitis 10.0
44 cystic lymphangioma 10.0
45 gallbladder cancer 10.0
46 lymphocele 10.0
47 lymphosarcoma 10.0
48 degos 'en cocarde' erythrokeratoderma 10.0
49 lymphangiomatosis 10.0
50 leukemia, chronic lymphocytic 2 9.9

Graphical network of the top 20 diseases related to Ascites, Chylous:



Diseases related to Ascites, Chylous

Symptoms & Phenotypes for Ascites, Chylous

Symptoms via clinical synopsis from OMIM:

57
Abdomen:
chylous ascites, congenital

Eye:
bilateral glaucoma

Limbs:
arm swelling


Clinical features from OMIM:

208300

Human phenotypes related to Ascites, Chylous:

59 32 (show all 9)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 subcutaneous nodule 59 32 frequent (33%) Frequent (79-30%) HP:0001482
2 ascites 59 32 hallmark (90%) Very frequent (99-80%) HP:0001541
3 neoplasm 59 32 occasional (7.5%) Occasional (29-5%) HP:0002664
4 lymphedema 59 32 hallmark (90%) Very frequent (99-80%) HP:0001004
5 pancreatitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001733
6 glaucoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0000501
7 abnormality of the intestine 59 Occasional (29-5%)
8 chylous ascites 32 HP:0012281
9 abnormal intestine morphology 32 occasional (7.5%) HP:0002242

Drugs & Therapeutics for Ascites, Chylous

Drugs for Ascites, Chylous (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Somatostatin Approved, Investigational Phase 2 51110-01-1, 38916-34-6 53481605
2
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
3 Antineoplastic Agents, Hormonal Phase 2
4 Gastrointestinal Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment With Octreotide in Patients With Lymphangioleiomyomatosis Completed NCT00005906 Phase 2 Octreotide
2 Chyle Leak After Pancreatic Surgery Recruiting NCT03079986 Not Applicable

Search NIH Clinical Center for Ascites, Chylous

Genetic Tests for Ascites, Chylous

Anatomical Context for Ascites, Chylous

MalaCards organs/tissues related to Ascites, Chylous:

41
Liver, Lymph Node, Breast, Heart, Prostate, T Cells, Kidney

Publications for Ascites, Chylous

Articles related to Ascites, Chylous:

(show top 50) (show all 664)
# Title Authors Year
1
A young woman with steroid-responsive, IgG4-positive plasma cell-enriched cystic lymphangioma and chylous ascites. ( 29881573 )
2018
2
Val30Met Familial Amyloid Polyneuropathy, Heart Failure, and Chylous Ascites: An Unexpected Combination. ( 29880429 )
2018
3
Portal hypertension and chylous ascites complicating acute pancreatitis: the therapeutic value of portal vein stenting. ( 29046075 )
2018
4
Chylous ascites, anti-interferon-gamma autoantibody, and angioimmunoblastic T-cell lymphoma: a rare but intriguing connection over Mycobacterium avium. ( 30083859 )
2018
5
Ultrasound-guided intranodal lymphangiography with lipiodol for treatment of chylous ascites following surgery for ovarian cancer: A case report. ( 30101017 )
2018
6
Therapeutic intranodal lymphangiography for refractory chylous ascites complicating acute necrotic pancreatitis. ( 29922765 )
2018
7
A female infant with phacomatosis pigmentovascularis and congenital chylous ascites: A case report. ( 30142845 )
2018
8
Chylous ascites and podocytopathy as the presentation of childhood lupus-an unusual occurrence. ( 30526330 )
2018
9
Chylous Ascites in an Infant with Thanatophoric Dysplasia Type I with FGFR3 Mutation Surviving Five Months. ( 30252581 )
2018
10
The incidence of chylous ascites after liver transplantation and the proposal of a diagnostic and management protocol. ( 28625694 )
2018
11
Chylous ascites due to idiopathic chronic pancreatitis managed with endoscopic stenting. ( 28645741 )
2018
12
Congenital chylous ascites in infants: another presentation of intestinal malrotation. ( 28648881 )
2018
13
Endolymphatic Balloon-Occluded Retrograde Abdominal Lymphangiography (BORAL) and Embolization (BORALE) for the Diagnosis and Treatment of Chylous Ascites: Approach, Technical Success, and Clinical Outcomes. ( 29217440 )
2018
14
Lymphangiography and Lymphatic Embolization for the Treatment of Refractory Chylous Ascites. ( 29238869 )
2018
15
Laparoscopic aproach in post-traumatic chylous ascites. ( 29364009 )
2018
16
Idiopathic chylous ascites in a patient with HIV infection: response to total parenteral nutrition and octreotide therapy. ( 29427281 )
2018
17
Successful Laparoscopic Treatment of Chylous Ascites after Pelvic Lymphadenectomy: A Case Report and Peanut Oil Application. ( 29427779 )
2018
18
Regarding "Management of refractory chylous ascites with peritoneovenous shunts". ( 29454443 )
2018
19
Infant fatality case with excessive chylous ascites. ( 29475120 )
2018
20
Endolymphatic Interventions for the Treatment of Chylothorax and Chylous Ascites in Neonates: Technical and Clinical Success and Complications. ( 29524461 )
2018
21
Chylous Ascites: A Review of Pathogenesis, Diagnosis and Treatment. ( 29577037 )
2018
22
A Case of Adenocarcinoma of the Lung With EGFR T790 Mutation Presenting With Chylous Ascites. ( 29631036 )
2018
23
Chylous ascites associated with abdominal trauma and intestinal resection-anastomosis in a pet ferret (Mustela putorius furo). ( 29701519 )
2018
24
A Case of Idiopathic Chylous Ascites Simulating Rupture of Hemorrhagic Cyst in the Ovary. ( 29902596 )
2018
25
Chylous ascites as a complication of intraabdominal Mycobacterium avium complex immune reconstitution inflammatory syndrome. ( 29904300 )
2018
26
Long standing biliary colic masking chylous ascites in laparoscopic roux-en-Y gastric bypass; a case report. ( 29914465 )
2018
27
Is There a Place for Repeat Lymphangiography in Postoperative Chylous Ascites? ( 29931386 )
2018
28
When Appearance Is Everything: Chylous Ascites. ( 30006131 )
2018
29
Laparoscopic management of refractory chylous ascites using fluorescence navigation with indocyanine green: A case report. ( 30007263 )
2018
30
WITHDRAWN: Underlying etiology determines the outcome in atraumatic chylous ascites. ( 30012891 )
2018
31
Mycobacterial chylous ascites: report of three cases and systematic review. ( 30013774 )
2018
32
Intranodal lymphangiography in the treatment of chylous ascites. ( 30087000 )
2018
33
The Feasibility of Mesenteric Intranodal Lymphangiography: Its Clinical Application for Refractory Postoperative Chylous Ascites. ( 30146199 )
2018
34
Underlying etiology determines the outcome in atraumatic chylous ascites. ( 30181937 )
2018
35
Idiopathic Chylous Ascites in Pregnancy: A Case Report. ( 30182003 )
2018
36
Microsurgical lymphaticovenular anastomosis for refractory chylous ascites following para-aortic lymph nodes dissection in a patient with tubal cancer. ( 30302363 )
2018
37
Retroperitoneal exploration with Vicryl mesh and fibrin tissue sealant for refractory chylous ascites. ( 30340876 )
2018
38
"Chylous Ascites: Complication of laparoscopic donor nephrectomy. Case Report and review of literature." ( 30399121 )
2018
39
Milky Mesentery: Acute Abdomen with Chylous Ascites. ( 30426960 )
2018
40
Lymphatic interventions for isolated, iatrogenic chylous ascites: A multi-institution experience. ( 30527310 )
2018
41
Retroperitoneal Fibrosis as a Cause of Chylous Ascites. ( 29090239 )
2017
42
A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax. ( 28487786 )
2017
43
A rare cause of acute abdomen: Chylous ascites. ( 28740965 )
2017
44
Chylous Ascites in a Newborn with Gastroschisis. Case Report. ( 28083502 )
2017
45
Chylous Ascites and Chylothorax Caused by Constrictive Pericarditis. ( 29052575 )
2017
46
Chylous ascites in focal segmental glomerulosclerosis. ( 28314586 )
2017
47
In vitro fertilization and pregnancy management in a woman with acquired idiopathic chylous ascites. ( 28737271 )
2017
48
Does BLOODCARE Powder Prevent Postoperative Chylous Ascites After Lymphadenectomy for Gynecological Malignancies? ( 28763366 )
2017
49
Lercanidipine-induced chylous ascites: Case report and literature review. ( 28485829 )
2017
50
Refractory Chylous Ascites Secondary to Neuroblastoma. ( 28481124 )
2017

Variations for Ascites, Chylous

Expression for Ascites, Chylous

Search GEO for disease gene expression data for Ascites, Chylous.

Pathways for Ascites, Chylous

GO Terms for Ascites, Chylous

Sources for Ascites, Chylous

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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