Ascites, Chylous disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

GARD: ¹⁹ Chylous ascites is a rare form of ascites caused by accumulation of lymph in the peritoneal cavity, usually due to intra-abdominal malignancy, liver cirrhosis or abdominal surgery complications, and present with painless but progressive abdominal distension, dyspnea and weight gain.

MalaCards based summary: Ascites, Chylous, also known as chylous ascites, is related to hennekam syndrome and liver cirrhosis. An important gene associated with Ascites, Chylous is SST (Somatostatin). Affiliated tissues include liver, lymph node and small intestine, and related phenotypes are lymphedema and ascites

Orphanet: ⁵⁸ Chylous ascites is a rare form of ascites caused by accumulation of lymph in the peritoneal cavity, usually due to intra-abdominal malignancy, liver cirrhosis or abdominal surgery complications, and present with painless but progressive abdominal distension, dyspnea and weight gain.

Wikipedia: ⁷⁵ Ascites is the abnormal build-up of fluid in the abdomen. Technically, it is more than 25 ml of fluid in... more...

More information from OMIM: 208300

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Related Diseases for Ascites, Chylous

Diseases related to Ascites, Chylous via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 366)

#	Related Disease	Score
1	hennekam syndrome	11.2
2	liver cirrhosis	10.7
3	peritonitis	10.7
4	aortic aneurysm	10.6
5	pancreatitis	10.6
6	aortic aneurysm, familial abdominal, 1	10.6
7	lymphangiectasis	10.6
8	lymphangioma	10.5
9	nutritional deficiency disease	10.5
10	hereditary lymphedema i	10.5
11	portal hypertension	10.5
12	pericarditis	10.5
13	lymphangioleiomyomatosis	10.5
14	constrictive pericarditis	10.5
15	vascular disease	10.5
16	acute pancreatitis	10.5
17	nephrotic syndrome	10.4
18	enterocele	10.4
19	testicular cancer	10.4
20	acquired immunodeficiency syndrome	10.4
21	rare lymphatic malformation	10.4
22	carcinoid tumors, intestinal	10.4
23	lymphangiectasia, intestinal	10.4
24	pancreatitis, hereditary	10.4
25	volvulus of midgut	10.4
26	lymphoma, hodgkin, classic	10.4
27	lymphoma	10.4
28	protein-losing enteropathy	10.4
29	lymphocele	10.4
30	appendicitis	10.4
31	systemic lupus erythematosus	10.4
32	gastric cancer	10.4
33	follicular lymphoma	10.4
34	inguinal hernia	10.4
35	lupus erythematosus	10.4
36	thrombosis	10.3
37	yellow nail syndrome	10.3
38	systemic lupus erythematosus 1	10.3
39	lymphoma, non-hodgkin, familial	10.3
40	human immunodeficiency virus type 1	10.3
41	macs syndrome	10.3
42	rectum cancer	10.3
43	lymphopenia	10.3
44	carcinoid syndrome	10.3
45	thrombophilia due to thrombin defect	10.3
46	wilms tumor 1	10.3
47	gastroschisis	10.3
48	pancreatic cancer	10.3
49	wilms tumor 5	10.3
50	cholangiocarcinoma	10.3

Graphical network of the top 20 diseases related to Ascites, Chylous:

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Symptoms & Phenotypes for Ascites, Chylous

Human phenotypes related to Ascites, Chylous:

⁵⁸ ³⁰ (show all 8)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	lymphedema ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0001004
2	ascites ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0001541
3	subcutaneous nodule ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001482
4	glaucoma ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000501
5	neoplasm ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002664
6	pancreatitis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001733
7	abnormal intestine morphology ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002242
8	chylous ascites ³⁰			HP:0012281

Symptoms via clinical synopsis from OMIM®:

⁵⁷ (Updated 08-Dec-2022)

Abdomen:
chylous ascites, congenital

Eye:
bilateral glaucoma

Limbs:
arm swelling

Clinical features from OMIM®:

208300 (Updated 08-Dec-2022)

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Drugs & Therapeutics for Ascites, Chylous

Search Clinical Trials, NIH Clinical Center for Ascites, Chylous

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Genetic Tests for Ascites, Chylous

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Anatomical Context for Ascites, Chylous

Organs/tissues related to Ascites, Chylous:

MalaCards : Liver, Lymph Node, Small Intestine, Testis, Pancreas, Heart, Lung

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Publications for Ascites, Chylous

Articles related to Ascites, Chylous:

(show top 50) (show all 1532)

#	Title	Authors	PMID	Year
1	Chylous ascites in sibs from a consanguineous marriage. ⁶² ⁵⁷	Flores S...Guizar-Vazquez J	474627	1979
2	Chylous ascites in siblings. ⁶² ⁵⁷	LEE CH...YOUNG JR	13011715	1953
3	Chylous ascites after excision of a choledochal cyst in a child. ⁵³ ⁶²	Huang CC...Lai HS	19433158	2009
4	Chylous ascites after living related liver transplantation treated with somatostatin analog and parenteral nutrition. ⁵³ ⁶²	Baran M...Kilic M	18261617	2008
5	Successful management of chylous ascites after living donor liver transplantation with somatostatin. ⁵³ ⁶²	Ijichi H...Maehara Y	18173563	2008
6	Successful management of chylous ascites with total parenteral nutrition, somatostatin, and fibrin glue. ⁵³ ⁶²	Huang Q...Fan YZ	18028785	2007
7	Octreotide therapy for chylous ascites in a chronic dialysis patient. ⁵³ ⁶²	Lee PH...Yang CW	16109079	2005
8	[Treatment of congenital chylous ascites using total parenteral nutrition and somatostatin: a case report]. ⁵³ ⁶²	Huang Y...Xu H	15833179	2005
9	Resolution of refractory chylous ascites after Kasai portoenterostomy using octreotide. ⁵³ ⁶²	Hwang JB...Park WH	15616936	2004
10	Chylous ascites: treated with total parenteral nutrition and somatostatin. ⁵³ ⁶²	Huang Q...Li JS	15300913	2004
11	Chylous ascites caused by portal vein thrombosis treated with octreotide. ⁵³ ⁶²	Leong RW...Jeffrey GP	12974913	2003
12	The diagnosis and management of postoperative chylous ascites. ⁵³ ⁶²	Leibovitch I...Ramon J	11792897	2002
13	Octreotide therapy: a new horizon in treatment of iatrogenic chyloperitoneum. ⁵³ ⁶²	Bhatia C...Slavik Z	11517107	2001
14	Rapid resolution of chylous ascites after liver transplantation using somatostatin analog and total parenteral nutrition. ⁵³ ⁶²	Shapiro AM...Kneteman NM	8629307	1996
15	Chylous ascites: Our experience from a resource-limited setting. ⁶²	Suleman M...Lodhia J	36463689	2022
16	An Uncommon Cause of Chylous Ascites in an Infant. ⁶²	Dash D...Gulla KM	36264414	2022
17	Could the chylomicron marker apoB48 be of value in the diagnosis of chylous effusions? ⁶²	Lefrere B...Bonnefont-Rousselot D	36463939	2022
18	Chylous Ascites: Reassessment of Diagnostic Criteria in Patients With Portal Hypertension. ⁶²	Matchett CL...Kamath PS	36379155	2022
19	Novel management indications for conservative treatment of chylous ascites after gastric cancer surgery. ⁶²	Kong PF...Xu DZ	36405388	2022
20	Large volume paracentesis of 39.5 liters chylous ascites in the setting of high-grade follicular lymphoma. ⁶²	Hughes JA...Wessinger JM	36124318	2022
21	Real world safety of CT-P10 (anti-CD 20 monoclonal antibodies biosimilar) in rheumatic and autoimmune diseases. ⁶²	Katchamart W...Dechapaphapitak N	36447248	2022
22	Chylous ascites in a case of henoch-schonlein purpura - A case report and literature review. ⁶²	Galam P...Mundakal JK	36412327	2022
23	Recurrent chylous ascites in patient with previous retroperitoneal radiation treatment. ⁶²	Sharma P...Chakraborty K	36316057	2022
24	Lymphatic Interventions in the Cancer Patient. ⁶²	Youssef EW...Santos E	35639331	2022
25	Diffuse Adrenal Gland and Pancreas Necrosis in a Patient with Disseminated Cryptococcosis-Case Report. ⁶²	Wappler-Guzzetta EA...Kerstetter JC	36295101	2022
26	Intranodal lipiodol injection for the treatment of chyle leak in children - a preliminary experience. ⁶²	Gupta A...Kandasamy D	35856789	2022
27	Incomplete lymphatic sealing around the inferior mesenteric artery is a risk factor for chylous ascites in robotic rectal cancer surgery. ⁶²	Ushigome H...Takiguchi S	36127882	2022
28	Successful treatment of chylous ascites by superselective embolization of the inflowing lymphatic vessels using a steerable microcatheter: a case study. ⁶²	Hamaguchi S...Ogawa Y	35801127	2022
29	Risk factors of chylous ascites and its relationship with long-term prognosis in laparoscopic D3 lymphadenectomy for right colon cancer. ⁶²	Qin W...Feng B	35589848	2022
30	Risk of Radiation Exposure to Clinical Staff from Paracenteses of Large-Volume Chylous Ascites After 177Lu-DOTATATE Infusion. ⁶²	Tipnis S...Gordon L	34933922	2022
31	Brief Report: Chylothorax and Chylous Ascites During RET Tyrosine Kinase Inhibitor Therapy. ⁶²	Kalchiem-Dekel O...Lin JJ	35788405	2022
32	Lymphatic anomalies in congenital heart disease. ⁶²	Ramirez-Suarez KI...Rapp JB	35840695	2022
33	Refractory ascites after laparoscopic cholecystectomy: a case report. ⁶²	Cheng X...Wang Q	35978331	2022
34	Impact of High Fat Diet and Bolus Feeding on Chyle Accumulation in a Mouse Model of Generalized Lymphatic Anomaly. ⁶²	Creed HA...Rutkowski JM	34748416	2022
35	Antibiotic-impregnated external ventricular drainage for the management of post-hemorrhagic hydrocephalus in low birth weight premature infants following intraventricular hemorrhage. ⁶²	Cheng YK...Liu CL	35513728	2022
36	Management of refractory chylous ascites: a challenge after lymphadenectomy. ⁶²	Rodriguez J...Pareja R	35914797	2022
37	Chyloperitoneum and Chylothorax Following Bariatric Surgery: a Systematic Review. ⁶²	Sakran N...Global Bariatric Research Collaborative	35674980	2022
38	ANGPTL4 silencing via antisense oligonucleotides reduces plasma triglycerides and glucose in mice without causing lymphadenopathy. ⁶²	Deng M...Kersten S	35667416	2022
39	Refractory congenital chylous ascites: First report of fibrin glue and mesh application by laparoscopy. ⁶²	Ojha S...Chaturvedi A	35708391	2022
40	Rapid Onset Chylous Ascites Presenting as the Initial Manifestation of Follicular Lymphoma: A Case Report. ⁶²	Weber B...Luke ND	36035034	2022
41	Management of chylous ascites with surgery and frusemide in a new born. ⁶²	Wabada S...Mustapha B	35775526	2022
42	Chylous ascites and pancreatic pseudocyst on a child following blunt abdominal trauma; a case report. ⁶²	Misso K...Msuya D	35839653	2022
43	Contemporary Management of Chylous Ascites after Retroperitoneal Surgery: Development of an Evidence-Based Treatment Algorithm. ⁶²	Rose KM...Sexton WJ	35212572	2022
44	Chylous Ascites Due to Hyperthyroidism and Heart Failure. ⁶²	Uchihara M...Hiraoka E	34897150	2022
45	Pancreatic Neuroendocrine Tumor Presenting with Chylous Ascites: Multidisciplinary Workup to Differentiate from Malignant Ascites. ⁶²	Ilagan-Ying YC...Gupta S	35260958	2022
46	Chylous ascites secondary to diffuse large B cell lynphoma. A case report. ⁶²	Gorrono Zamalloa I...Orive Calzada A	34273424	2022
47	Chyloperitoneum due to gastric carcinoma: a case report. ⁶²	Pinto JC...Casimiro C	35769185	2022
48	Cardiac Amyloidosis: A Rare Cause of Recurrent Chylothorax. ⁶²	Patel R...Anwer F	35702470	2022
49	Postoperative chylous ascites after total gastrectomy successfully treated using peritoneovenous (Denver) shunt: a case report. ⁶²	Sakamoto S...Okabayashi T	35534589	2022
50	Unusual Presentation of Bilateral Chylothorax and Chylous Ascites with Pancreatic Adenocarcinoma: A Case Report. ⁶²	Fangsaard P...Ungtrakul T	35949900	2022

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Genes for Ascites, Chylous

Genes related to Ascites, Chylous (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	SST	Somatostatin	Protein Coding	7.5	Novoseek inferred ⁵³	18261617 15300913 19433158 (more) 8629307 18173563 15616936 16109079 11517107 15833179 12974913 11792897 18028785

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Variations for Ascites, Chylous

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Expression for Ascites, Chylous

Search GEO for disease gene expression data for Ascites, Chylous.

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Pathways for Ascites, Chylous

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GO Terms for Ascites, Chylous

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Sources for Ascites, Chylous

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⁵⁷ OMIM® (Updated 08-Dec-2022)

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MCID: ASC009 MIFTS: 35	Ascites, Chylous Categories: Gastrointestinal diseases, Immune diseases, Liver diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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