MCID: ASC009
MIFTS: 38

Ascites, Chylous

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Ascites, Chylous

MalaCards integrated aliases for Ascites, Chylous:

Name: Ascites, Chylous 58
Chylous Ascites 77 54 60 74
Congenital Chylous Ascites 54 74
Ascites Chylous 56

Characteristics:

OMIM:

58
Inheritance:
autosomal recessive


HPO:

33
ascites, chylous:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 58 208300
MESH via Orphanet 46 D002915
ICD10 via Orphanet 35 I89.8
UMLS via Orphanet 75 C0008732
Orphanet 60 ORPHA1160
MedGen 43 C0008732

Summaries for Ascites, Chylous

NIH Rare Diseases : 54 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 1160Disease definitionChylous ascites is a rare form of ascites caused by accumulation of lymph in the peritoneal cavity, usually due to intra-abdominal malignancy, liver cirrhosis or abdominal surgery complications, and present with painless but progressive abdominal distension, dyspnea and weight gain.Visit the Orphanet disease page for more resources.

MalaCards based summary : Ascites, Chylous, also known as chylous ascites, is related to pancreatitis and aortic aneurysm, familial abdominal, 1. An important gene associated with Ascites, Chylous is SST (Somatostatin). The drugs Somatostatin and Octreotide have been mentioned in the context of this disorder. Affiliated tissues include liver, lymph node and prostate, and related phenotypes are ascites and lymphedema

Wikipedia : 77 Ascites is the abnormal buildup of fluid in the abdomen. Technically, it is more than 25 mL of fluid in... more...

Description from OMIM: 208300

Related Diseases for Ascites, Chylous

Diseases related to Ascites, Chylous via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 155)
# Related Disease Score Top Affiliating Genes
1 pancreatitis 10.5
2 aortic aneurysm, familial abdominal, 1 10.4
3 lymphoma 10.4
4 aortic aneurysm 10.4
5 pericarditis 10.4
6 peritonitis 10.4
7 lymphangioleiomyomatosis 10.3
8 constrictive pericarditis 10.3
9 liver cirrhosis 10.3
10 thrombosis 10.3
11 nephrotic syndrome 10.3
12 acute pancreatitis 10.3
13 lymphedema 10.2
14 lupus erythematosus 10.2
15 lymphangiectasis 10.2
16 colorectal cancer 10.2
17 systemic lupus erythematosus 10.2
18 yellow nail syndrome 10.2
19 gastroschisis 10.2
20 wilms tumor 5 10.2
21 wilms tumor 6 10.2
22 lymphangioma 10.2
23 acquired immunodeficiency syndrome 10.2
24 appendicitis 10.2
25 rere-related disorders 10.2
26 carcinoid syndrome 10.2
27 abdominal wall defect 10.2
28 bile duct cysts 10.1
29 focal segmental glomerulosclerosis 1 10.1
30 focal segmental glomerulosclerosis 10.1
31 inguinal hernia 10.1
32 portal vein thrombosis 10.1
33 intestinal volvulus 10.1
34 thrombophilia due to thrombin defect 10.0
35 pancreatic cancer 10.0
36 cervical cancer 10.0
37 endometrial cancer 10.0
38 gastric cancer 10.0
39 membranous nephropathy 10.0
40 leptin deficiency or dysfunction 10.0
41 angioimmunoblastic t-cell lymphoma 10.0
42 protein-losing enteropathy 10.0
43 portal hypertension 10.0
44 mesenteric lymphadenitis 10.0
45 graves' disease 10.0
46 diarrhea 10.0
47 lymphadenitis 10.0
48 cystic lymphangioma 10.0
49 gallbladder cancer 10.0
50 lymphocele 10.0

Graphical network of the top 20 diseases related to Ascites, Chylous:



Diseases related to Ascites, Chylous

Symptoms & Phenotypes for Ascites, Chylous

Human phenotypes related to Ascites, Chylous:

60 33 (show all 9)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ascites 60 33 hallmark (90%) Very frequent (99-80%) HP:0001541
2 lymphedema 60 33 hallmark (90%) Very frequent (99-80%) HP:0001004
3 subcutaneous nodule 60 33 frequent (33%) Frequent (79-30%) HP:0001482
4 neoplasm 60 33 occasional (7.5%) Occasional (29-5%) HP:0002664
5 pancreatitis 60 33 occasional (7.5%) Occasional (29-5%) HP:0001733
6 glaucoma 60 33 occasional (7.5%) Occasional (29-5%) HP:0000501
7 abnormal intestine morphology 33 occasional (7.5%) HP:0002242
8 abnormality of the intestine 60 Occasional (29-5%)
9 chylous ascites 33 HP:0012281

Symptoms via clinical synopsis from OMIM:

58
Abdomen:
chylous ascites, congenital

Eye:
bilateral glaucoma

Limbs:
arm swelling

Clinical features from OMIM:

208300

Drugs & Therapeutics for Ascites, Chylous

Drugs for Ascites, Chylous (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Somatostatin Approved, Investigational Phase 2 38916-34-6, 51110-01-1 53481605
2
Octreotide Approved, Investigational Phase 2 83150-76-9 6400441 383414
3 Gastrointestinal Agents Phase 2
4 Antineoplastic Agents, Hormonal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment With Octreotide in Patients With Lymphangioleiomyomatosis Completed NCT00005906 Phase 2 Octreotide
2 Chyle Leak After Pancreatic Surgery Recruiting NCT03079986 Not Applicable

Search NIH Clinical Center for Ascites, Chylous

Genetic Tests for Ascites, Chylous

Anatomical Context for Ascites, Chylous

MalaCards organs/tissues related to Ascites, Chylous:

42
Liver, Lymph Node, Prostate, Heart, Testes, Testis, Lung

Publications for Ascites, Chylous

Articles related to Ascites, Chylous:

(show top 50) (show all 679)
# Title Authors Year
1
Chylous ascites, anti-interferon-gamma autoantibody, and angioimmunoblastic T-cell lymphoma: a rare but intriguing connection over Mycobacterium avium. ( 30083859 )
2019
2
Chylous ascites in disseminated Kaposi sarcoma: an unusual manifestation as immune reconstitution inflammatory syndrome. ( 30904896 )
2019
3
Management of postoperative chylous ascites after surgery for ovarian cancer: a single-institution experience. ( 31006086 )
2019
4
Val30Met Familial Amyloid Polyneuropathy, Heart Failure, and Chylous Ascites: An Unexpected Combination. ( 29880429 )
2019
5
Chylous ascites and podocytopathy as the presentation of childhood lupus-an unusual occurrence. ( 30526330 )
2019
6
Intranodal lymphangiography in the treatment of chylous ascites. ( 30087000 )
2019
7
Retroperitoneal exploration with Vicryl mesh and fibrin tissue sealant for refractory chylous ascites. ( 30340876 )
2019
8
Chylous Ascites: Complication of Laparoscopic Donor Nephrectomy. Case Report and Review of Literature. ( 30399121 )
2019
9
Percutaneous Balloon Plasty for Thoracic Duct Occlusion in a Patient with Chylothorax and Chylous Ascites. ( 30617452 )
2019
10
Chylous ascites following laparoscopic live donor nephrectomy: A new improved treatment paradigm. ( 30661276 )
2019
11
Chylothorax secondary to a pleuroperitoneal communication and chylous ascites after pancreatic resection. ( 30697412 )
2019
12
Laparoscopic surgical repair of refractory chylous ascites after laparoscopic anterior resection. ( 30734160 )
2019
13
Direct percutaneous embolization of intestinal lymphatic trunk for chylous ascites management following liver transplant. ( 30899336 )
2019
14
Milking the System: Dietary Therapy of Post-nephrectomy Chylous Ascites. ( 30949904 )
2019
15
Calcium Channel Blocker-Related Chylous Ascites: A Systematic Review and Meta-Analysis. ( 30959848 )
2019
16
Successful percutaneous embolization of refractory chylous ascites following peritoneal lymph node dissection. ( 30988860 )
2019
17
3-Methylcholanthrene Induces Chylous Ascites in TCDD-Inducible Poly-ADP-Ribose Polymerase (Tiparp) Knockout Mice. ( 31083300 )
2019
18
A Case of Idiopathic Chylous Ascites Simulating Rupture of Hemorrhagic Cyst in the Ovary. ( 29902596 )
2019
19
Heparin in Congenital Chylothorax and Chylous Ascites. ( 31012049 )
2019
20
Portal hypertension and chylous ascites complicating acute pancreatitis: the therapeutic value of portal vein stenting. ( 29046075 )
2018
21
A young woman with steroid-responsive, IgG4-positive plasma cell-enriched cystic lymphangioma and chylous ascites. ( 29881573 )
2018
22
Chylous Ascites due to Mantle Cell Lymphoma. ( 30756045 )
2018
23
Ultrasound-guided intranodal lymphangiography with lipiodol for treatment of chylous ascites following surgery for ovarian cancer: A case report. ( 30101017 )
2018
24
Therapeutic intranodal lymphangiography for refractory chylous ascites complicating acute necrotic pancreatitis. ( 29922765 )
2018
25
Chylous ascites due to idiopathic chronic pancreatitis managed with endoscopic stenting. ( 28645741 )
2018
26
A female infant with phacomatosis pigmentovascularis and congenital chylous ascites: A case report. ( 30142845 )
2018
27
Chylous Ascites in an Infant with Thanatophoric Dysplasia Type I with FGFR3 Mutation Surviving Five Months. ( 30252581 )
2018
28
Long standing biliary colic masking chylous ascites in laparoscopic roux-en-Y gastric bypass; a case report. ( 29914465 )
2018
29
Is There a Place for Repeat Lymphangiography in Postoperative Chylous Ascites? ( 29931386 )
2018
30
When Appearance Is Everything: Chylous Ascites. ( 30006131 )
2018
31
Laparoscopic management of refractory chylous ascites using fluorescence navigation with indocyanine green: A case report. ( 30007263 )
2018
32
WITHDRAWN: Underlying etiology determines the outcome in atraumatic chylous ascites. ( 30012891 )
2018
33
Mycobacterial chylous ascites: report of three cases and systematic review. ( 30013774 )
2018
34
The Feasibility of Mesenteric Intranodal Lymphangiography: Its Clinical Application for Refractory Postoperative Chylous Ascites. ( 30146199 )
2018
35
Underlying etiology determines the outcome in atraumatic chylous ascites. ( 30181937 )
2018
36
Idiopathic Chylous Ascites in Pregnancy: A Case Report. ( 30182003 )
2018
37
Microsurgical lymphaticovenular anastomosis for refractory chylous ascites following para-aortic lymph nodes dissection in a patient with tubal cancer. ( 30302363 )
2018
38
Milky Mesentery: Acute Abdomen with Chylous Ascites. ( 30426960 )
2018
39
Lymphatic interventions for isolated, iatrogenic chylous ascites: A multi-institution experience. ( 30527310 )
2018
40
Low-Dose Radiotherapy is an Effective Treatment for Refractory Post-Operative Chylous Ascites: A Case Report. ( 30562613 )
2018
41
Chylous ascites as a complication of intraabdominal Mycobacterium avium complex immune reconstitution inflammatory syndrome. ( 29904300 )
2018
42
Chylous ascites associated with abdominal trauma and intestinal resection-anastomosis in a pet ferret (Mustela putorius furo). ( 29701519 )
2018
43
A Case of Adenocarcinoma of the Lung With EGFR T790 Mutation Presenting With Chylous Ascites. ( 29631036 )
2018
44
Chylous Ascites: A Review of Pathogenesis, Diagnosis and Treatment. ( 29577037 )
2018
45
Endolymphatic Interventions for the Treatment of Chylothorax and Chylous Ascites in Neonates: Technical and Clinical Success and Complications. ( 29524461 )
2018
46
Infant fatality case with excessive chylous ascites. ( 29475120 )
2018
47
Regarding "Management of refractory chylous ascites with peritoneovenous shunts". ( 29454443 )
2018
48
Successful Laparoscopic Treatment of Chylous Ascites after Pelvic Lymphadenectomy: A Case Report and Peanut Oil Application. ( 29427779 )
2018
49
Idiopathic chylous ascites in a patient with HIV infection: response to total parenteral nutrition and octreotide therapy. ( 29427281 )
2018
50
Laparoscopic aproach in post-traumatic chylous ascites. ( 29364009 )
2018

Variations for Ascites, Chylous

Expression for Ascites, Chylous

Search GEO for disease gene expression data for Ascites, Chylous.

Pathways for Ascites, Chylous

GO Terms for Ascites, Chylous

Sources for Ascites, Chylous

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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