MCID: ASP003
MIFTS: 56

Aseptic Meningitis

Categories: Neuronal diseases

Aliases & Classifications for Aseptic Meningitis

MalaCards integrated aliases for Aseptic Meningitis:

Name: Aseptic Meningitis 12 76 3 15 73
Acute Aseptic Meningitis 12
Meningitis, Aseptic 44
Meningitis Aseptic 55

Classifications:



External Ids:

Disease Ontology 12 DOID:12157
ICD10 33 G03.0
MeSH 44 D008582
NCIt 50 C118299
SNOMED-CT 68 58170007
UMLS 73 C0025290

Summaries for Aseptic Meningitis

Disease Ontology : 12 A meningitis that is characterized by meningeal inflammation not caused by an identifiable bacterial pathogen in the cerebrospinal fluid. A large majority of them are caused by enteroviruses.

MalaCards based summary : Aseptic Meningitis, also known as acute aseptic meningitis, is related to meningitis and poliomyelitis. An important gene associated with Aseptic Meningitis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Carboplatin and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and spinal cord, and related phenotypes are hematopoietic system and cellular

CDC : 3 Español: Meningitis viral

Wikipedia : 76 Aseptic meningitis is the inflammation of the meninges, a membrane covering the brain and spinal cord in... more...

Related Diseases for Aseptic Meningitis

Diseases related to Aseptic Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 421)
# Related Disease Score Top Affiliating Genes
1 meningitis 31.6 CXCL8 IFNG IL10 IL1B NLRP3 TNF
2 poliomyelitis 30.6 IFNG IL10 TNF
3 bacterial meningitis 30.4 CXCL8 IL10 IL1B TNF
4 multiple sclerosis 30.4 IFNG IL10 IL1B TNF
5 connective tissue disease 30.4 IFNG IL10 TNF
6 mixed connective tissue disease 30.3 IFNG IL10 TNF
7 leptospirosis 30.2 CXCL8 IFNG IL10 IL1B TNF
8 exanthem 30.2 IL1RN NLRP3 TNF
9 myasthenia gravis 30.2 IFNG IL10 TNF
10 common variable immunodeficiency 30.2 IFNG IL10 TNF
11 lymphadenitis 30.1 CXCL8 IFNG IL10 IL1B TNF
12 pericarditis 30.1 IFNG IL1B IL1RN TNF
13 scrub typhus 30.1 IL10 IL1B TNF
14 psoriatic arthritis 30.1 CD58 IL1B TNF
15 mouth disease 30.1 IFNG IL10 IL1B TNF
16 neuritis 30.1 IFNG IL1B TNF
17 familial mediterranean fever 30.0 IL1B IL1RN NLRP3 TNF
18 central nervous system disease 30.0 IFNG IL1B TNF
19 mycobacterium tuberculosis 1 29.9 IFNG IL10 TNF
20 adult-onset still's disease 29.9 CSF1 IL1B IL1R1 IL1RN TNF
21 transverse myelitis 29.9 CXCL8 IL10 TNF
22 systemic lupus erythematosus 29.9 CSF1 CXCL8 IFNG IL10 IL1B TNF
23 typhoid fever 29.8 IFNG IL1B TNF
24 hepatitis a 29.8 IFNG IL10 TNF
25 adult respiratory distress syndrome 29.8 CXCL8 IL10 TNF
26 gastroenteritis 29.8 CXCL8 IL10 IL1B TNF
27 human immunodeficiency virus infectious disease 29.8 IFNG IL10 TNF
28 otitis media 29.8 CXCL8 IL10 IL1B TNF
29 pneumonia 29.7 CXCL8 IL10 IL1B TNF
30 arthritis 29.7 CSF1 CXCL8 IFNG IL10 IL1B IL1RN
31 juvenile rheumatoid arthritis 29.7 IL1B IL1R1 IL1RN TNF
32 uveitis 29.6 IFNG IL10 IL1R1 TNF
33 viral infectious disease 29.6 CXCL8 IFNG IL10 IL1B TNF
34 diabetes mellitus 29.6 IFNG IL1B IL1RN SOD2 TNF
35 psoriasis 29.5 CXCL8 IFNG IL10 IL1B TNF
36 haemophilus influenzae 29.5 CXCL8 IL1B LTF TNF
37 aspergillosis 29.4 IFNG IL10 TNF
38 rheumatoid arthritis 29.3 CSF1 CXCL8 IFNG IL10 IL1B IL1R1
39 syphilitic aseptic meningitis 12.5
40 mollaret meningitis 12.0
41 nonparalytic poliomyelitis 11.6
42 lymphocytic choriomeningitis 11.6
43 viral meningitis 11.5
44 syphilitic meningitis 11.4
45 epidermoid brain cyst 11.4
46 mumps 10.6
47 encephalitis 10.4
48 measles 10.4
49 rubella 10.4
50 herpes simplex 10.3

Graphical network of the top 20 diseases related to Aseptic Meningitis:



Diseases related to Aseptic Meningitis

Symptoms & Phenotypes for Aseptic Meningitis

MGI Mouse Phenotypes related to Aseptic Meningitis:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.21 CSF1 IFNG IL10 IL1B IL1R1 IL1RN
2 cellular MP:0005384 10.2 CSF1 IFNG IL10 IL1R1 IL1RN LTF
3 homeostasis/metabolism MP:0005376 10.19 CSF1 IFNG IL10 IL1B IL1R1 IL1RN
4 growth/size/body region MP:0005378 10.18 CSF1 IFNG IL10 IL1B IL1R1 IL1RN
5 immune system MP:0005387 10.18 CSF1 IFNG IL10 IL1B IL1R1 IL1RN
6 cardiovascular system MP:0005385 10.16 CSF1 IFNG IL10 IL1B IL1R1 IL1RN
7 integument MP:0010771 10.11 CSF1 IFNG IL10 IL1B IL1R1 IL1RN
8 mortality/aging MP:0010768 10.06 CSF1 IFNG IL10 IL1B IL1R1 IL1RN
9 liver/biliary system MP:0005370 10.03 CSF1 IFNG IL10 IL1R1 LTF NLRP3
10 craniofacial MP:0005382 10.01 CSF1 IFNG IL10 IL1B IL1R1 TNF
11 neoplasm MP:0002006 9.87 IFNG IL10 IL1B IL1R1 LTF SOD2
12 nervous system MP:0003631 9.86 CSF1 IFNG IL10 IL1B IL1R1 NLRP3
13 muscle MP:0005369 9.85 CSF1 IFNG IL10 IL1R1 SOD2 TNF
14 reproductive system MP:0005389 9.7 CSF1 IFNG IL10 IL1RN NLRP3 SOD2
15 skeleton MP:0005390 9.56 CSF1 IFNG IL10 IL1B IL1R1 IL1RN
16 vision/eye MP:0005391 9.1 CSF1 IFNG IL10 IL1R1 SOD2 TNF

Drugs & Therapeutics for Aseptic Meningitis

Drugs for Aseptic Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
2
leucovorin Approved Phase 2 58-05-9 6006 143
3
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
4
rituximab Approved Phase 2 174722-31-7 10201696
5
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
6
Methotrexate Approved Phase 2 59-05-2, 1959-05-2 126941
7
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
8
Busulfan Approved, Investigational Phase 2 55-98-1 2478
9
Ifosfamide Approved Phase 2 3778-73-2 3690
10
Clonazepam Approved, Illicit Phase 2 1622-61-3 2802
11
Etoposide Approved Phase 2 33419-42-0 36462
12
Carmustine Approved, Investigational Phase 2 154-93-8 2578
13
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
14
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
15
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
16 Immunologic Factors Phase 2
17 Immunoglobulins, Intravenous Phase 2
18 Immunoglobulins Phase 2
19 gamma-Globulins Phase 2
20 Immunoglobulin G Phase 2
21 Rho(D) Immune Globulin Phase 2
22 Antibodies Phase 2
23 Folate Phase 2
24 Hydrocortisone 17-butyrate 21-propionate Phase 2
25
Isophosphamide mustard Phase 2 0
26 Topoisomerase Inhibitors Phase 2
27 Vitamin B9 Phase 2
28 Antirheumatic Agents Phase 2
29 Vitamin B Complex Phase 2
30 Immunosuppressive Agents Phase 2
31 Antineoplastic Agents, Alkylating Phase 2
32 Antiviral Agents Phase 2
33 Anti-Infective Agents Phase 2
34 Folic Acid Antagonists Phase 2
35 Alkylating Agents Phase 2
36 Antineoplastic Agents, Phytogenic Phase 2
37 Antimetabolites Phase 2
38 Etoposide phosphate Phase 2
39 Dermatologic Agents Phase 2
40 Antimetabolites, Antineoplastic Phase 2
41 Nucleic Acid Synthesis Inhibitors Phase 2
42 Cortisol succinate Phase 2
43
Lamotrigine Approved, Investigational 84057-84-1 3878
44
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
45
Acyclovir Approved 59277-89-3 2022
46
Ceftriaxone Approved 73384-59-5 5479530 5361919
47
Dopamine Approved 51-61-6, 62-31-7 681
48 Neurotransmitter Agents
49 Excitatory Amino Acids
50 Calcium, Dietary

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
2 New Combination of Chemoimmunotherapy for Systemic B-cell Lymphoma With Central Nervous System Involvement Recruiting NCT02329080 Phase 2 Methotrexate;Rituximab;Cytarabine;Thiotepa;liposomial cytarabine;Etoposide;Ifosfamide;Carmustine
3 WEUSKOP6166: Lamotrigine and Aseptic Meningitis Completed NCT01657864 Lamotrigine
4 DuraSeal Sealant Post Market Study Completed NCT00704340 Not Applicable
5 Aseptic Meningoencephalitis in Slovenia Recruiting NCT02328469 symptomatic therapy;Ceftriaxone or Doxycycline;Acyclovir
6 Posterior Fossa Decompression With or Without Duraplasty for Chiari Type I Malformation With Syringomyelia Recruiting NCT02669836 Not Applicable
7 Central Nervous System Infections in Denmark Recruiting NCT03418441
8 Transsphenoidal Extent of Resection Study Active, not recruiting NCT02357498 Not Applicable
9 A New Enzymatic Assay for Rapid Diagnosing of Central Nervous System Enteroviral Infection Withdrawn NCT00864903

Search NIH Clinical Center for Aseptic Meningitis

Cochrane evidence based reviews: meningitis, aseptic

Genetic Tests for Aseptic Meningitis

Anatomical Context for Aseptic Meningitis

MalaCards organs/tissues related to Aseptic Meningitis:

41
Testes, Brain, Spinal Cord, T Cells, Liver, Neutrophil, Lung

Publications for Aseptic Meningitis

Articles related to Aseptic Meningitis:

(show top 50) (show all 977)
# Title Authors Year
1
Systemic inflammatory disorders in patients admitted for aseptic meningitis. ( 29626017 )
2018
2
Drug-induced aseptic meningitis: A possible T-cell-mediated hypersensitivity. ( 29310902 )
2018
3
Aseptic Meningitis as a Complication of Daratumumab Therapy. ( 29903471 )
2018
4
Cerebrospinal fluid lactate as a marker to differentiate between community-acquired acute bacterial meningitis and aseptic meningitis/encephalitis in adults: a Danish prospective observational cohort study. ( 29490540 )
2018
5
Infliximab-Induced Aseptic Meningitis in a Patient with Crohn's Disease. ( 29951563 )
2018
6
Aseptic meningitis caused by the Varicella-zoster virus after primary infection in an immunocompetent child: a case report. ( 29623894 )
2018
7
Drug-induced aseptic meningitis: a mini-review. ( 29364542 )
2018
8
Kikuchi's disease (histiocytic necrotizing lymphadenitis): A rare presentation with acute kidney injury, peripheral neuropathy, and aseptic meningitis with cutaneous involvement. ( 29567898 )
2018
9
Analysis of enterovirus types in patients with symptoms of aseptic meningitis in 2014 in Shandong, China. ( 29407377 )
2018
10
Capillary leak syndrome and aseptic meningitis in a patient with Kawasaki disease: A case report. ( 29879013 )
2018
11
ISMP Adverse Drug Reactions: Adalimumab-Induced Aseptic Meningitis Pill Desiccant -Induced Acute Hypoxic Respiratory Failure Rivastigmine Patch -Induced Angioedema Acute Liver Failure Due to Etodolac Severe Cognitive Impairment Due to High Free Valproic Acid Levels. ( 30210145 )
2018
12
Immunoglobulin-induced aseptic meningitis: a case report. ( 30016937 )
2018
13
Effect of Staphylococcal Decolonization Regimen and Change in Antibiotic Prophylaxis Regimen on Incidence of Postcraniotomy Aseptic Meningitis. ( 30075267 )
2018
14
Coxsackievirus B5 Aseptic Meningitis in Infants in Chiba Prefecture, Japan, in 2016. ( 30135347 )
2018
15
Aseptic meningitis as a manifestation of a mitochondrial disorder. ( 30154904 )
2018
16
Acute aseptic meningitis during isotretinoin treatment for nodular acne solely presenting with headache: case report and brief review of the literature. ( 30160569 )
2018
17
Varicella Zoster aseptic meningitis: Report of an atypical case in an immunocompetent patient treated with oral valacyclovir. ( 30167375 )
2018
18
Recurrent aseptic meningitis with PIGT mutations: a novel pathogenesis of recurrent meningitis successfully treated by eculizumab. ( 30262533 )
2018
19
A Teenage Girl With Aseptic Meningitis and Abdominal Pain. ( 30299426 )
2018
20
Recurrent Amoxicillin-Induced Aseptic Meningitis. ( 30430972 )
2018
21
Combined testing for herpes simplex virus and Mycobacterium tuberculosis DNA in cerebrospinal fluid of patients with aseptic meningitis in Burkina Faso, West Africa. ( 30474140 )
2018
22
A Rare Case of Levetiracetam and Drug-Induced Idiopathic Aseptic Meningitis in a Pediatric Patient. ( 30488976 )
2018
23
Pearls & Oy-sters: Neuro-Sweet disease presenting as ischemic stroke and aseptic meningitis. ( 30510029 )
2018
24
Genetic diversity of the enteroviruses detected from cerebrospinal fluid (CSF) samples of patients with suspected aseptic meningitis in northern West Bank, Palestine in 2017. ( 30532168 )
2018
25
Atypical type of familial Mediterranean fever: An underdiagnosed cause of chronic aseptic meningitis. ( 30546872 )
2018
26
Increased risk for aseptic meningitis after amoxicillin or amoxicillin-clavulanic acid in males: A signal revealed by subset disproportionality analysis within a global database of suspected adverse drug reactions. ( 30556617 )
2018
27
USE OF SCORE AND CEREBROSPINAL FLUID LACTATE DOSAGE IN DIFFERENTIAL DIAGNOSIS OF BACTERIAL AND ASEPTIC MENINGITIS. ( 29185620 )
2017
28
Clinical, epidemiological and etiological studies of adult aseptic meningitis: Report of 11 cases with varicella zoster virus meningitis. ( 28804114 )
2017
29
Recurrent natalizumab-related aseptic meningitis in a patient with multiple sclerosis. ( 28639536 )
2017
30
Serum interleukin-6 levels as an indicator of aseptic meningitis among children with enterovirus 71-induced hand, foot and mouth disease. ( 29231065 )
2017
31
Association of anti-triosephosphate isomerase antibodies with aseptic meningitis in patients with neuropsychiatric systemic lupus erythematosus. ( 28451873 )
2017
32
Recurrent trimethoprim-sulfamethoxazole-induced aseptic meningitis with associated ampicillin-induced myoclonic twitchesa8c. ( 28291512 )
2017
33
Not All Aseptic Meningitis Is Created Equal. ( 29191826 )
2017
34
First Case Report of Aseptic Meningitis Induced by Adalimumab Administered for Treatment of Chronic Plaque Psoriasis. ( 28570223 )
2017
35
Clinical commentary on 'Recurrent natalizumab-related aseptic meningitis in a patient with multiple sclerosis', by Foley et al. ( 28639492 )
2017
36
Aseptic meningitis due to reperfusion injury after carotid artery stenting. ( 28991696 )
2017
37
Metagenomic Sequencing of an Echovirus 30 Genome From Cerebrospinal Fluid of a Patient With Aseptic Meningitis and Orchitis. ( 28761901 )
2017
38
Aseptic meningitis following a bupivacaine spinal anesthesia. ( 28904717 )
2017
39
A Teenage Girl With Aseptic Meningitis and Unilateral Blurry Vision. ( 28687842 )
2017
40
IVIG Associated Aseptic Meningitis in a Renal Transplant Patient. ( 28620559 )
2017
41
Infliximab-Induced Aseptic Meningitis during the Treatment of Psoriatic Arthritis. ( 28611632 )
2017
42
Risk Factors for Aseptic Meningitis in Herpes Zoster Patients. ( 28566903 )
2017
43
Cerebrospinal Fluid Cytokines Correlate With Aseptic Meningitis and Blood-Brain Barrier Function in Neonatal-Onset Multisystem Inflammatory Disease: Central Nervous System Biomarkers in Neonatal-Onset Multisystem Inflammatory Disease Correlate With Central Nervous System Inflammation. ( 28118536 )
2017
44
Enhancing global vaccine pharmacovigilance: Proof-of-concept study on aseptic meningitis and immune thrombocytopenic purpura following measles-mumps containing vaccination. ( 28558983 )
2017
45
Aseptic meningitis in adults and children: Diagnostic and management challenges. ( 28806629 )
2017
46
Molecular detection and genotyping of enteroviruses from CSF samples of patients with suspected sepsis-like illness and/or aseptic meningitis from 2012 to 2015 in West Bank, Palestine. ( 28225788 )
2017
47
A case of aseptic meningitis in a cetuximab-experienced patient with metastatic colon cancer. ( 29157147 )
2017
48
Chemokines CXCL10, CXCL11, and CXCL13 in acute disseminated encephalomyelitis, non-polio enterovirus aseptic meningitis, and neuroborreliosis: CXCL10 as initial discriminator in diagnostic algorithm? ( 29288471 )
2017
49
Human enteroviruses in cerebrospinal fluid of children with suspected aseptic meningitis: A study in northern Iran. ( 28702151 )
2017
50
Aseptic meningitis in relapsing polychondritis: a case report and literature review. ( 28361234 )
2017

Variations for Aseptic Meningitis

Expression for Aseptic Meningitis

Search GEO for disease gene expression data for Aseptic Meningitis.

Pathways for Aseptic Meningitis

Pathways related to Aseptic Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 CD58 CSF1 CXCL8 IFNG IL10 IL1B
2
Show member pathways
13.61 CSF1 CXCL8 IFNG IL10 IL1B IL1R1
3
Show member pathways
13.46 CXCL8 IFNG IL10 IL1B IL1R1 TNF
4
Show member pathways
13.35 CSF1 CXCL8 IL10 IL1B IL1R1 TNF
5
Show member pathways
13.31 CSF1 CXCL8 IFNG IL10 IL1B IL1R1
6
Show member pathways
13.26 CSF1 CXCL8 IL10 IL1B IL1R1 TNF
7
Show member pathways
12.99 CXCL8 IFNG IL10 IL1B NLRP3 TNF
8
Show member pathways
12.85 CXCL8 IFNG IL10 IL1B TNF
9
Show member pathways
12.78 CXCL8 IFNG IL1B NLRP3 TNF
10 12.71 CSF1 IL1B IL1R1 TNF
11
Show member pathways
12.7 CXCL8 IFNG IL1B TNF
12
Show member pathways
12.63 IFNG IL1B IL1R1 TNF
13
Show member pathways
12.59 IFNG IL10 IL1B IL1R1 TNF
14
Show member pathways
12.56 IFNG IL10 IL1B TNF
15 12.56 IFNG IL10 IL1B IL1RN TNF
16
Show member pathways
12.42 IFNG IL10 IL1B TNF
17
Show member pathways
12.34 CXCL8 IFNG IL1B TNF
18
Show member pathways
12.34 CSF1 IFNG IL1B SOD2 TNF
19
Show member pathways
12.32 CXCL8 IFNG IL1B IL1R1 TNF
20
Show member pathways
12.27 IFNG IL10 IL1B TNF
21
Show member pathways
12.26 CXCL8 IFNG IL10 IL1B TNF
22 12.24 IFNG IL10 IL1B TNF
23
Show member pathways
12.23 CXCL8 IL1B IL1R1 IL1RN TNF
24
Show member pathways
12.22 IL10 IL1B NLRP3 TNF
25
Show member pathways
12.22 IFNG IL1B NLRP3 TNF
26
Show member pathways
12.18 CXCL8 IFNG IL1B IL1R1 TNF
27 12.17 CXCL8 IL10 IL1B IL1RN TNF
28 12.11 IFNG IL1B IL1R1 TNF
29
Show member pathways
12.08 CXCL8 IFNG IL10 IL1B IL1R1
30
Show member pathways
12.05 IFNG IL10 IL1B IL1R1 TNF
31 12.03 CSF1 IFNG IL1B IL1R1 TNF
32
Show member pathways
12.01 IFNG IL1B TNF
33 12.01 CSF1 IFNG IL10 TNF
34 12 CXCL8 IL10 IL1B TNF
35 11.99 CXCL8 IFNG IL1B IL1R1 TNF
36
Show member pathways
11.96 IFNG IL1B IL1R1
37 11.94 CSF1 IL1B TNF
38 11.93 CSF1 IL1B IL1R1 TNF
39 11.92 CXCL8 IFNG IL1B
40 11.91 CXCL8 IL1B IL1R1 TNF
41 11.89 CXCL8 IL1B TNF
42 11.83 CXCL8 IFNG IL1B
43 11.81 CSF1 CXCL8 IFNG IL1B TNF
44
Show member pathways
11.77 CXCL8 IFNG TNF
45 11.73 IFNG IL10 IL1B IL1R1 TNF
46
Show member pathways
11.71 CXCL8 IFNG IL1B TNF
47 11.68 CXCL8 IL1B TNF
48 11.68 CXCL8 IL10 IL1B NLRP3 TNF
49 11.64 CSF1 IFNG IL10 IL1B TNF
50 11.62 CXCL8 IL1B TNF

GO Terms for Aseptic Meningitis

Cellular components related to Aseptic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 CSF1 CXCL8 IFNG IL10 IL1B IL1RN
2 extracellular region GO:0005576 9.32 CSF1 CXCL8 IFNG IL10 IL1B IL1R1

Biological processes related to Aseptic Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.95 CXCL8 IFNG IL10 IL1B IL1R1 IL1RN
2 defense response GO:0006952 9.87 CXCL8 NLRP3 TNF
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.87 IL1B IL1RN LTF TNF
4 regulation of signaling receptor activity GO:0010469 9.87 CSF1 CXCL8 IFNG IL10 IL1B IL1RN
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.85 IL10 IL1B TNF
6 neutrophil chemotaxis GO:0030593 9.85 CXCL8 IL1B IL1RN
7 positive regulation of JNK cascade GO:0046330 9.84 IL1B IL1RN TNF
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 IL1B LTF NLRP3 TNF
9 regulation of inflammatory response GO:0050727 9.82 IL1R1 NLRP3 TNF
10 regulation of insulin secretion GO:0050796 9.82 IFNG IL1B TNF
11 positive regulation of interleukin-6 production GO:0032755 9.8 IL1B IL1RN TNF
12 humoral immune response GO:0006959 9.8 IFNG LTF TNF
13 interleukin-1-mediated signaling pathway GO:0070498 9.77 IL1B IL1R1 IL1RN
14 interleukin-12-mediated signaling pathway GO:0035722 9.76 IFNG IL10 SOD2
15 positive regulation of interferon-gamma production GO:0032729 9.75 IL1B IL1R1 TNF
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.73 IFNG IL1B TNF
17 response to glucocorticoid GO:0051384 9.73 IL10 IL1B IL1RN TNF
18 negative regulation of neurogenesis GO:0050768 9.71 IL1B TNF
19 positive regulation of protein complex assembly GO:0031334 9.71 IFNG TNF
20 leukocyte chemotaxis GO:0030595 9.71 CXCL8 IL10
21 positive regulation of neutrophil chemotaxis GO:0090023 9.71 CXCL8 IL1B
22 positive regulation of JUN kinase activity GO:0043507 9.71 IL1B IL1RN TNF
23 protein import into nucleus, translocation GO:0000060 9.7 IFNG TNF
24 embryonic digestive tract development GO:0048566 9.69 CXCL8 TNF
25 negative regulation of lipid catabolic process GO:0050995 9.69 IL1B TNF
26 positive regulation of glial cell proliferation GO:0060252 9.69 IL1B TNF
27 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.68 IL1B TNF
28 negative regulation of growth of symbiont in host GO:0044130 9.68 IL10 TNF
29 response to molecule of bacterial origin GO:0002237 9.68 CXCL8 IL10
30 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.67 IL10 IL1RN
31 positive regulation of osteoclast differentiation GO:0045672 9.67 CSF1 IFNG TNF
32 endothelial cell apoptotic process GO:0072577 9.66 IL10 TNF
33 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IL1B TNF
34 negative regulation of glutamate secretion GO:0014050 9.65 IL1B IL1RN
35 regulation of establishment of endothelial barrier GO:1903140 9.65 IL1B TNF
36 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IFNG IL1B TNF
37 negative regulation of cytokine secretion involved in immune response GO:0002740 9.64 IL10 TNF
38 positive regulation of neuroinflammatory response GO:0150078 9.63 IL1B TNF
39 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL10 IL1B TNF
40 cellular response to lipopolysaccharide GO:0071222 9.63 CXCL8 IL10 IL1B IL1RN NLRP3 TNF
41 interleukin-1 beta production GO:0032611 9.62 IL1B NLRP3
42 positive regulation of fever generation GO:0031622 9.61 IL1B TNF
43 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.61 IL1B IL1R1
44 sequestering of triglyceride GO:0030730 9.59 IL1B TNF
45 receptor biosynthetic process GO:0032800 9.55 IL10 TNF
46 chronic inflammatory response to antigenic stimulus GO:0002439 9.54 IL1B IL1RN TNF
47 positive regulation of vitamin D biosynthetic process GO:0060557 9.51 IFNG TNF
48 cytokine-mediated signaling pathway GO:0019221 9.5 CSF1 CXCL8 IL10 IL1B IL1R1 IL1RN
49 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 IFNG IL1B TNF
50 inflammatory response GO:0006954 9.23 CSF1 CXCL8 IL10 IL1B IL1R1 IL1RN

Molecular functions related to Aseptic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CSF1 CXCL8 IFNG IL10 IL1B IL1RN
2 interleukin-1 receptor binding GO:0005149 8.96 IL1B IL1RN

Sources for Aseptic Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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