MCID: ASP003
MIFTS: 54

Aseptic Meningitis

Categories: Neuronal diseases

Aliases & Classifications for Aseptic Meningitis

MalaCards integrated aliases for Aseptic Meningitis:

Name: Aseptic Meningitis 12 76 3 15 73
Acute Aseptic Meningitis 12
Meningitis, Aseptic 44
Meningitis Aseptic 55

Classifications:



External Ids:

Disease Ontology 12 DOID:12157
ICD10 33 G03.0
MeSH 44 D008582
NCIt 50 C118299
UMLS 73 C0025290

Summaries for Aseptic Meningitis

CDC : 3 Viral meningitis is the most common type of meningitis, an inflammation of the tissue that covers the brain and spinal cord. It is often less severe than bacterial meningitis, and most people get better on their own (without treatment). However, it’s very important for anyone with symptoms of meningitis to see a healthcare provider right away because some types of meningitis can be very serious, and only a doctor can determine if you have the disease, the type of meningitis, and the best treatment, which can sometimes be lifesaving. Babies younger than 1 month old and people with weakened immune systems are more likely to have severe illness from viral meningitis.

MalaCards based summary : Aseptic Meningitis, also known as acute aseptic meningitis, is related to mixed connective tissue disease and poliomyelitis. An important gene associated with Aseptic Meningitis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Busulfan and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Aseptic meningitis is the inflammation of the meninges, a membrane covering the brain and spinal cord in... more...

Related Diseases for Aseptic Meningitis

Diseases related to Aseptic Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 392)
# Related Disease Score Top Affiliating Genes
1 mixed connective tissue disease 30.6 IFNG IL10 TNF
2 poliomyelitis 30.6 IFNG IL10 TNF
3 neuritis 30.5 IFNG IL1B TNF
4 bacterial meningitis 30.5 CXCL8 IL10 IL1B TNF
5 scrub typhus 30.4 IL10 IL1B TNF
6 meningitis 30.4 CXCL8 IFNG IL10 IL1B NLRP3 TNF
7 haemophilus influenzae 30.4 CXCL8 IL1B TNF
8 myasthenia gravis 30.3 IFNG IL10 TNF
9 exanthem 30.3 IL1RN NLRP3 TNF
10 typhoid fever 30.3 IFNG IL1B TNF
11 leptospirosis 30.3 CXCL8 IL10 IL1B TNF
12 transverse myelitis 30.2 CXCL8 IL10 TNF
13 crohn's disease 30.2 IL10 IL1B TNF
14 adult respiratory distress syndrome 30.2 CXCL8 IL10 TNF
15 multiple sclerosis 30.1 IFNG IL10 IL1B TNF
16 adult-onset still's disease 30.1 IL1B IL1R1 IL1RN TNF
17 pneumonia 30.0 CXCL8 IL10 IL1B TNF
18 mouth disease 29.9 IFNG IL10 IL1B TNF
19 common variable immunodeficiency 29.9 IFNG IL10 TNF
20 connective tissue disease 29.8 IFNG IL10 IL1A TNF
21 otitis media 29.8 CXCL8 IL10 IL1B TNF
22 lymphadenitis 29.7 CXCL8 IFNG IL10 IL1B TNF
23 familial mediterranean fever 29.6 IL1B IL1RN NLRP3 TNF
24 juvenile rheumatoid arthritis 29.5 IL1B IL1R1 IL1RN TNF
25 brucellosis 29.4 CXCL8 IFNG IL10 IL1RN TNF
26 psoriatic arthritis 29.1 CD58 IL1A IL1B TNF
27 uveitis 28.5 IFNG IL10 IL1A IL1R1 TNF
28 arthritis 28.3 CXCL8 IFNG IL10 IL1A IL1B IL1RN
29 psoriasis 28.3 CXCL8 IFNG IL10 IL1A IL1B TNF
30 diabetes mellitus 28.1 IFNG IL1A IL1B IL1RN SOD2 TNF
31 rheumatoid arthritis 27.4 CXCL8 IFNG IL10 IL1A IL1B IL1R1
32 syphilitic aseptic meningitis 12.4
33 mollaret meningitis 11.9
34 nonparalytic poliomyelitis 11.4
35 viral meningitis 11.4
36 lymphocytic choriomeningitis 11.4
37 syphilitic meningitis 11.2
38 epidermoid brain cyst 11.2
39 recurrent corneal erosion 10.9 CXCL8 IL1B
40 bagassosis 10.8 CXCL8 IL1B
41 systemic onset juvenile idiopathic arthritis 10.8 IL1B TNF
42 streptococcal toxic-shock syndrome 10.8 CXCL8 TNF
43 kashin-beck disease 10.8 IL1B TNF
44 peptic esophagitis 10.8 CXCL8 IL1B
45 punctate inner choroidopathy 10.7 IL10 TNF
46 burns 10.7 IL1B TNF
47 tropical endomyocardial fibrosis 10.7 IL10 TNF
48 trichosporonosis 10.7 IFNG TNF
49 acute transverse myelitis 10.7 CXCL8 IL10
50 chronic beryllium disease 10.7 IFNG TNF

Graphical network of the top 20 diseases related to Aseptic Meningitis:



Diseases related to Aseptic Meningitis

Symptoms & Phenotypes for Aseptic Meningitis

GenomeRNAi Phenotypes related to Aseptic Meningitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 IL10 IL1A IL1B NLRP3 TNF CD2
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 IL10 IL1A IL1B NLRP3 TNF CD2

MGI Mouse Phenotypes related to Aseptic Meningitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.06 TNF IL1RN IL10 NLRP3 IL1A SOD2
2 cardiovascular system MP:0005385 10.03 TNF IL1RN IL10 IL1A SOD2 IL1B
3 homeostasis/metabolism MP:0005376 10.02 TNF IL1RN IL10 NLRP3 IL1A SOD2
4 immune system MP:0005387 9.97 TNF IL1RN IL10 NLRP3 IL1A SOD2
5 integument MP:0010771 9.91 TNF IL10 IL1RN NLRP3 IL1A SOD2
6 liver/biliary system MP:0005370 9.63 TNF IL10 NLRP3 SOD2 IFNG IL1R1
7 neoplasm MP:0002006 9.5 TNF IL10 IL1A SOD2 IL1B IFNG
8 skeleton MP:0005390 9.17 TNF IL1RN IL10 NLRP3 IL1B IFNG

Drugs & Therapeutics for Aseptic Meningitis

Drugs for Aseptic Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Busulfan Approved, Investigational Phase 2 55-98-1 2478
2
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
3
Carmustine Approved, Investigational Phase 2 154-93-8 2578
4
Clonazepam Approved, Illicit Phase 2 1622-61-3 2802
5
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
6
Etoposide Approved Phase 2 33419-42-0 36462
7
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
8
Ifosfamide Approved Phase 2 3778-73-2 3690
9
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
10
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
11
rituximab Approved Phase 2 174722-31-7 10201696
12
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
13
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
14
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
15 Antibodies Phase 2
16 gamma-Globulins Phase 2
17 Immunoglobulin G Phase 2
18 Immunoglobulins Phase 2
19 Immunoglobulins, Intravenous Phase 2
20 Rho(D) Immune Globulin Phase 2
21 Alkylating Agents Phase 2
22 Anti-Infective Agents Phase 2
23 Antimetabolites Phase 2
24 Antimetabolites, Antineoplastic Phase 2
25 Antineoplastic Agents, Alkylating Phase 2
26 Antineoplastic Agents, Phytogenic Phase 2
27 Antirheumatic Agents Phase 2
28 Antiviral Agents Phase 2
29 Cortisol succinate Phase 2
30 Dermatologic Agents Phase 2
31 Etoposide phosphate Phase 2
32 Folic Acid Antagonists Phase 2
33 Hydrocortisone 17-butyrate 21-propionate Phase 2
34 Hydrocortisone acetate Phase 2
35 Immunosuppressive Agents Phase 2
36
Isophosphamide mustard Phase 2 0
37 Nucleic Acid Synthesis Inhibitors Phase 2
38 Topoisomerase Inhibitors Phase 2
39 Vitamin B Complex Phase 2
40 Folate Nutraceutical Phase 2
41 Vitamin B9 Nutraceutical Phase 2
42
Lamotrigine Approved, Investigational 84057-84-1 3878
43
Acyclovir Approved 59277-89-3 2022
44
Ceftriaxone Approved 73384-59-5 5479530 5361919
45
Dopamine Approved 51-61-6, 62-31-7 681
46
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
47 Anticonvulsants
48 calcium channel blockers
49 Calcium, Dietary
50 Diuretics, Potassium Sparing

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
2 New Combination of Chemoimmunotherapy for Systemic B-cell Lymphoma With Central Nervous System Involvement Recruiting NCT02329080 Phase 2 Methotrexate;Rituximab;Cytarabine;Thiotepa;liposomial cytarabine;Etoposide;Ifosfamide;Carmustine
3 WEUSKOP6166: Lamotrigine and Aseptic Meningitis Completed NCT01657864 Lamotrigine
4 DuraSeal Sealant Post Market Study Completed NCT00704340 Not Applicable
5 Aseptic Meningoencephalitis in Slovenia Recruiting NCT02328469 symptomatic therapy;Ceftriaxone or Doxycycline;Acyclovir
6 Posterior Fossa Decompression With or Without Duraplasty for Chiari Type I Malformation With Syringomyelia Recruiting NCT02669836 Not Applicable
7 Central Nervous System Infections in Denmark Recruiting NCT03418441
8 Transsphenoidal Extent of Resection Study Recruiting NCT02357498 Not Applicable
9 A New Enzymatic Assay for Rapid Diagnosing of Central Nervous System Enteroviral Infection Withdrawn NCT00864903

Search NIH Clinical Center for Aseptic Meningitis

Cochrane evidence based reviews: meningitis, aseptic

Genetic Tests for Aseptic Meningitis

Anatomical Context for Aseptic Meningitis

MalaCards organs/tissues related to Aseptic Meningitis:

41
Brain, Spinal Cord, Testes, B Cells, T Cells, Pituitary, Myeloid

Publications for Aseptic Meningitis

Articles related to Aseptic Meningitis:

(show top 50) (show all 627)
# Title Authors Year
1
Systemic inflammatory disorders in patients admitted for aseptic meningitis. ( 29626017 )
2018
2
Drug-induced aseptic meningitis: A possible T-cell-mediated hypersensitivity. ( 29310902 )
2018
3
Aseptic Meningitis as a Complication of Daratumumab Therapy. ( 29903471 )
2018
4
Cerebrospinal fluid lactate as a marker to differentiate between community-acquired acute bacterial meningitis and aseptic meningitis/encephalitis in adults: a Danish prospective observational cohort study. ( 29490540 )
2018
5
Infliximab-Induced Aseptic Meningitis in a Patient with Crohn's Disease. ( 29951563 )
2018
6
Aseptic meningitis caused by the Varicella-zoster virus after primary infection in an immunocompetent child: a case report. ( 29623894 )
2018
7
Drug-induced aseptic meningitis: a mini-review. ( 29364542 )
2018
8
Kikuchi's disease (histiocytic necrotizing lymphadenitis): A rare presentation with acute kidney injury, peripheral neuropathy, and aseptic meningitis with cutaneous involvement. ( 29567898 )
2018
9
Analysis of enterovirus types in patients with symptoms of aseptic meningitis in 2014 in Shandong, China. ( 29407377 )
2018
10
Capillary leak syndrome and aseptic meningitis in a patient with Kawasaki disease: A case report. ( 29879013 )
2018
11
USE OF SCORE AND CEREBROSPINAL FLUID LACTATE DOSAGE IN DIFFERENTIAL DIAGNOSIS OF BACTERIAL AND ASEPTIC MENINGITIS. ( 29185620 )
2017
12
Clinical, epidemiological and etiological studies of adult aseptic meningitis: Report of 11 cases with varicella zoster virus meningitis. ( 28804114 )
2017
13
Recurrent natalizumab-related aseptic meningitis in a patient with multiple sclerosis. ( 28639536 )
2017
14
Serum interleukin-6 levels as an indicator of aseptic meningitis among children with enterovirus 71-induced hand, foot and mouth disease. ( 29231065 )
2017
15
Association of anti-triosephosphate isomerase antibodies with aseptic meningitis in patients with neuropsychiatric systemic lupus erythematosus. ( 28451873 )
2017
16
Recurrent trimethoprim-sulfamethoxazole-induced aseptic meningitis with associated ampicillin-induced myoclonic twitchesa8c. ( 28291512 )
2017
17
Not All Aseptic Meningitis Is Created Equal. ( 29191826 )
2017
18
First Case Report of Aseptic Meningitis Induced by Adalimumab Administered for Treatment of Chronic Plaque Psoriasis. ( 28570223 )
2017
19
Clinical commentary on 'Recurrent natalizumab-related aseptic meningitis in a patient with multiple sclerosis', by Foley et al. ( 28639492 )
2017
20
Aseptic meningitis due to reperfusion injury after carotid artery stenting. ( 28991696 )
2017
21
Metagenomic Sequencing of an Echovirus 30 Genome From Cerebrospinal Fluid of a Patient With Aseptic Meningitis and Orchitis. ( 28761901 )
2017
22
Aseptic meningitis following a bupivacaine spinal anesthesia. ( 28904717 )
2017
23
A Teenage Girl With Aseptic Meningitis and Unilateral Blurry Vision. ( 28687842 )
2017
24
IVIG Associated Aseptic Meningitis in a Renal Transplant Patient. ( 28620559 )
2017
25
Infliximab-Induced Aseptic Meningitis during the Treatment of Psoriatic Arthritis. ( 28611632 )
2017
26
Risk Factors for Aseptic Meningitis in Herpes Zoster Patients. ( 28566903 )
2017
27
Cerebrospinal Fluid Cytokines Correlate With Aseptic Meningitis and Blood-Brain Barrier Function in Neonatal-Onset Multisystem Inflammatory Disease: Central Nervous System Biomarkers in Neonatal-Onset Multisystem Inflammatory Disease Correlate With Central Nervous System Inflammation. ( 28118536 )
2017
28
Enhancing global vaccine pharmacovigilance: Proof-of-concept study on aseptic meningitis and immune thrombocytopenic purpura following measles-mumps containing vaccination. ( 28558983 )
2017
29
Aseptic meningitis in adults and children: Diagnostic and management challenges. ( 28806629 )
2017
30
Molecular detection and genotyping of enteroviruses from CSF samples of patients with suspected sepsis-like illness and/or aseptic meningitis from 2012 to 2015 in West Bank, Palestine. ( 28225788 )
2017
31
A case of aseptic meningitis in a cetuximab-experienced patient with metastatic colon cancer. ( 29157147 )
2017
32
Chemokines CXCL10, CXCL11, and CXCL13 in acute disseminated encephalomyelitis, non-polio enterovirus aseptic meningitis, and neuroborreliosis: CXCL10 as initial discriminator in diagnostic algorithm? ( 29288471 )
2017
33
Human enteroviruses in cerebrospinal fluid of children with suspected aseptic meningitis: A study in northern Iran. ( 28702151 )
2017
34
Aseptic meningitis in relapsing polychondritis: a case report and literature review. ( 28361234 )
2017
35
Herpes zoster-related aseptic meningitis and encephalomeningitis: A single faculty retrospective case study. ( 28557114 )
2017
36
Pathogenesis of coxsackievirus B2 in mice: characterisation of clinical isolates of the coxsackievirus B2 from patients with myocarditis and aseptic meningitis in Korea. ( 28384999 )
2017
37
Molecular identification of human enteroviruses associated with aseptic meningitis in Yunnan province, Southwest China. ( 27652088 )
2016
38
Cetuximab-induced aseptic meningitis: case report and review of a rare adverse event. ( 27378078 )
2016
39
Blood-CSF-barrier dysfunction is a marker for encephalitic involvement in patients with aseptic meningitis/meningoencephalitis. ( 27736668 )
2016
40
Cat-scratch disease presenting as parotid gland abscess and aseptic meningitis. ( 27426218 )
2016
41
A Rare Complication of Trimethoprim-Sulfamethoxazole: Drug Induced Aseptic Meningitis. ( 27579194 )
2016
42
Complete Genome Sequence Analysis of Echovirus 18 Associated with Aseptic Meningitis in Hebei Province, China, in 2015. ( 27789638 )
2016
43
Aseptic meningitis following therapy with immune globulins: a combination of product features and patient characteristics? ( 27807853 )
2016
44
Amoxicillin-induced aseptic meningitis: case report and review of published casesa8c. ( 27443662 )
2016
45
Etiologies and Management of Aseptic Meningitis in Patients Admitted to an Internal Medicine Department. ( 26765411 )
2016
46
Herpes simplex virus type 2-associated recurrent aseptic meningitis (Mollaret's meningitis) with a recurrence after 11-year interval: a case report. ( 27773908 )
2016
47
A case of aseptic meningitis without neck rigidity occurring in a metastatic melanoma patient treated with ipilimumab. ( 28007669 )
2016
48
Ehrlichiosis Induced Aseptic Meningitis and Second Degree Heart Block in an Adolescent Male. ( 27097347 )
2016
49
Aseptic Meningitis with Craniopharyngioma Resection: Consideration after Endoscopic Surgery. ( 27722072 )
2016
50
Neurosarcoidosis Presenting as Aseptic Meningitis in an Immunosuppressed Renal Transplant Recipient. ( 26863472 )
2016

Variations for Aseptic Meningitis

Expression for Aseptic Meningitis

Search GEO for disease gene expression data for Aseptic Meningitis.

Pathways for Aseptic Meningitis

Pathways related to Aseptic Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 CD58 CXCL8 IFNG IL10 IL1A IL1B
2
Show member pathways
13.62 CD2 CXCL8 IFNG IL10 IL1A IL1B
3
Show member pathways
13.5 CD2 CXCL8 IFNG IL10 IL1A IL1B
4
Show member pathways
13.4 CD2 CXCL8 IL10 IL1A IL1B IL1R1
5
Show member pathways
13.36 CXCL8 IFNG IL10 IL1A IL1B IL1R1
6
Show member pathways
13.3 CD2 CXCL8 IL10 IL1A IL1B IL1R1
7
Show member pathways
13.02 CXCL8 IFNG IL10 IL1B NLRP3 TNF
8
Show member pathways
12.9 CXCL8 IFNG IL10 IL1A IL1B TNF
9
Show member pathways
12.82 CXCL8 IFNG IL1A IL1B NLRP3 TNF
10
Show member pathways
12.8 IFNG IL1A IL1B IL1R1 TNF
11 12.71 IL1A IL1B IL1R1 TNF
12
Show member pathways
12.71 CXCL8 IFNG IL1B TNF
13
Show member pathways
12.69 IFNG IL1A IL1B IL1R1 TNF
14
Show member pathways
12.67 CXCL8 IFNG IL10 IL1A IL1B TNF
15
Show member pathways
12.66 IL1A IL1B IL1R1 TNF
16 12.61 CD2 IFNG IL10 IL1B IL1RN TNF
17
Show member pathways
12.57 IFNG IL10 IL1B TNF
18
Show member pathways
12.54 IL1A IL1B IL1R1 TNF
19
Show member pathways
12.48 IFNG IL10 IL1A IL1B TNF
20
Show member pathways
12.46 IFNG IL10 IL1A IL1B IL1R1 TNF
21
Show member pathways
12.36 IFNG IL1B SOD2 TNF
22
Show member pathways
12.36 CXCL8 IFNG IL1B TNF
23
Show member pathways
12.33 IL1A IL1B IL1R1 IL1RN
24
Show member pathways
12.32 IFNG IL10 IL1B IL1R1 TNF
25
Show member pathways
12.31 IFNG IL10 IL1A IL1B TNF
26 12.29 IFNG IL10 IL1A IL1B TNF
27
Show member pathways
12.27 IFNG IL1A IL1B NLRP3 TNF
28
Show member pathways
12.25 IL10 IL1B NLRP3 TNF
29
Show member pathways
12.24 CXCL8 IFNG IL1B IL1R1 TNF
30
Show member pathways
12.23 CXCL8 IFNG IL1A IL1B IL1R1 TNF
31
Show member pathways
12.2 CXCL8 IL1A IL1B IL1R1 IL1RN TNF
32 12.15 IFNG IL1A IL1B IL1R1 TNF
33 12.11 IFNG IL1A IL1B IL1R1 TNF
34 12.09 CXCL8 IL10 IL1A IL1B IL1RN TNF
35 12.05 CD2 IFNG IL10 TNF
36
Show member pathways
12.05 CD2 CXCL8 IFNG IL10 IL1A IL1B
37 12.02 CXCL8 IL10 IL1A IL1B TNF
38
Show member pathways
12.01 IL1A IL1B IL1R1
39 12.01 CXCL8 IFNG IL1A IL1B
40 11.98 CXCL8 IL1A IL1B TNF
41
Show member pathways
11.96 IFNG IL1B IL1R1
42 11.95 CXCL8 IL1B IL1R1 TNF
43 11.93 CD2 IL1A IL1B IL1R1 TNF
44 11.9 CXCL8 IFNG IL1A IL1B
45 11.88 CXCL8 IFNG IL1A IL1B TNF
46 11.88 CXCL8 IFNG IL1A IL1B IL1R1 TNF
47 11.82 IFNG IL10 IL1B TNF
48 11.81 IFNG IL10 IL1B IL1R1 TNF
49
Show member pathways
11.79 CXCL8 IFNG TNF
50 11.72 CXCL8 IFNG IL10 IL1B IL1R1 TNF

GO Terms for Aseptic Meningitis

Cellular components related to Aseptic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CXCL8 IFNG IL10 IL1A IL1B IL1RN
2 extracellular region GO:0005576 9.32 CD2 CXCL8 IFNG IL10 IL1A IL1B

Biological processes related to Aseptic Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 IFNG IL1A IL1B TNF
2 negative regulation of cell proliferation GO:0008285 9.97 CXCL8 IL10 IL1A IL1B SOD2
3 leukocyte migration GO:0050900 9.91 CD2 CD58 IL1B TNF
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.89 IL1A IL1B TNF
5 positive regulation of protein phosphorylation GO:0001934 9.88 IFNG IL1B TNF
6 defense response GO:0006952 9.88 CXCL8 NLRP3 TNF
7 positive regulation of angiogenesis GO:0045766 9.87 CXCL8 IL1A IL1B
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.87 IL1B NLRP3 TNF
9 regulation of signaling receptor activity GO:0010469 9.87 CXCL8 IFNG IL10 IL1A IL1B IL1RN
10 positive regulation of DNA binding transcription factor activity GO:0051091 9.85 IL10 IL1B TNF
11 regulation of inflammatory response GO:0050727 9.83 IL1R1 NLRP3 TNF
12 positive regulation of JNK cascade GO:0046330 9.81 IL1A IL1B TNF
13 regulation of insulin secretion GO:0050796 9.81 IFNG IL1B TNF
14 cellular response to lipopolysaccharide GO:0071222 9.81 CXCL8 IL10 NLRP3 TNF
15 response to glucocorticoid GO:0051384 9.8 IL10 IL1RN TNF
16 positive regulation of interleukin-6 production GO:0032755 9.77 IL1A IL1B TNF
17 interleukin-1-mediated signaling pathway GO:0070498 9.76 IL1A IL1B IL1R1 IL1RN
18 interleukin-12-mediated signaling pathway GO:0035722 9.75 IFNG IL10 SOD2
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.73 IFNG IL1B TNF
20 positive regulation of mitotic nuclear division GO:0045840 9.71 IL1A IL1B
21 positive regulation of protein complex assembly GO:0031334 9.71 IFNG TNF
22 heterotypic cell-cell adhesion GO:0034113 9.71 CD2 CD58
23 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.71 IL1A IL1B TNF
24 positive regulation of osteoclast differentiation GO:0045672 9.7 IFNG TNF
25 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.7 IL1B NLRP3 TNF
26 inflammatory response GO:0006954 9.7 CXCL8 IL10 IL1A IL1B IL1RN NLRP3
27 embryonic digestive tract development GO:0048566 9.69 CXCL8 TNF
28 negative regulation of lipid catabolic process GO:0050995 9.69 IL1B TNF
29 negative regulation of growth of symbiont in host GO:0044130 9.68 IL10 TNF
30 positive regulation of interleukin-8 secretion GO:2000484 9.68 CD2 CD58
31 response to molecule of bacterial origin GO:0002237 9.68 CXCL8 IL10
32 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.67 IL1A IL1B
33 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.67 IL1A IL1B
34 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.66 IL10 IL1RN
35 positive regulation of chemokine biosynthetic process GO:0045080 9.65 IL1B TNF
36 endothelial cell apoptotic process GO:0072577 9.65 IL10 TNF
37 ectopic germ cell programmed cell death GO:0035234 9.65 IL1A IL1B
38 positive regulation of cytokine secretion GO:0050715 9.65 IL10 IL1A TNF
39 regulation of establishment of endothelial barrier GO:1903140 9.64 IL1B TNF
40 negative regulation of cytokine secretion involved in immune response GO:0002740 9.62 IL10 TNF
41 positive regulation of fever generation GO:0031622 9.62 IL1B TNF
42 positive regulation of neutrophil extravasation GO:2000391 9.61 IL1A IL1R1
43 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IFNG IL1B TNF
44 interleukin-1 beta production GO:0032611 9.59 IL1B NLRP3
45 sequestering of triglyceride GO:0030730 9.58 IL1B TNF
46 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL10 IL1B TNF
47 receptor biosynthetic process GO:0032800 9.55 IL10 TNF
48 fever generation GO:0001660 9.54 IL1A IL1B IL1RN
49 cytokine-mediated signaling pathway GO:0019221 9.5 CXCL8 IL10 IL1A IL1B IL1R1 IL1RN
50 positive regulation of vitamin D biosynthetic process GO:0060557 9.49 IFNG TNF

Molecular functions related to Aseptic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CXCL8 IFNG IL10 IL1A IL1B IL1RN
2 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN

Sources for Aseptic Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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