Aseptic Meningitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ASP003 MIFTS: 51	Aseptic Meningitis Categories: Cancer diseases, Infectious diseases, Neuronal diseases
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Aliases & Classifications for Aseptic Meningitis

MalaCards integrated aliases for Aseptic Meningitis:

Name: Aseptic Meningitis ¹² ⁷³ ³⁶ ³ ¹⁵ ¹⁷ ⁷⁰

Acute Aseptic Meningitis ¹²

Meningitis, Aseptic ⁴⁴

Meningitis Aseptic ⁵⁴

Classifications:

MalaCards categories:
Global: Cancer diseases Infectious diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the nervous system

Inflammatory diseases of the central nervous system

Meningitis due to other and unspecified causes

Nonpyogenic meningitis

External Ids:

Disease Ontology ¹² DOID:12157

KEGG ³⁶ H01429

MeSH ⁴⁴ D008582

NCIt ⁵⁰ C118299

SNOMED-CT ⁶⁷ 186490006

ICD10 ³² G03.0

EFO ¹⁷ EFO_1000823

UMLS ⁷⁰ C0025290

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Summaries for Aseptic Meningitis

CDC : ³ Viral meningitis is the most common type of meningitis, an inflammation of the lining of the brain and spinal cord. It is often less severe than bacterial meningitis, and most people get better on their own (without treatment). However, anyone with symptoms of meningitis should see a doctor right away because some types of meningitis can be very serious. Only a doctor can determine if someone has meningitis, what is causing it, and the best treatment. Babies younger than 1 month old and people with weakened immune systems are more likely to have severe illness from viral meningitis.

MalaCards based summary : Aseptic Meningitis, also known as acute aseptic meningitis, is related to syphilitic meningitis and mumps. An important gene associated with Aseptic Meningitis is IL1R1 (Interleukin 1 Receptor Type 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Ceftriaxone and Acyclovir have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and pituitary, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : ¹² A meningitis that is characterized by meningeal inflammation not caused by an identifiable bacterial pathogen in the cerebrospinal fluid. A large majority of them are caused by enteroviruses.

KEGG : ³⁶ Aseptic meningitis is one of the most common inflammatory disorders of the meninges and includes all types of meningitis not due to pyogenic bacteria. It has a very broad etiology, including both viral and non-viral infections, drugs, malignancy, and systemic illness. Viral meningitis constitutes the most common cause of aseptic meningitis. Clinical manifestations include headache, fever, malaise, photophobia, and meningeal signs.

Wikipedia : ⁷³ Aseptic meningitis is the inflammation of the meninges, a membrane covering the brain and spinal cord,... more...

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Related Diseases for Aseptic Meningitis

Diseases related to Aseptic Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 846)

#	Related Disease	Score	Top Affiliating Genes
1	syphilitic meningitis	32.5	TNF CXCL13 CRP
2	mumps	31.4	TNF IL1B IL10 IFNG CXCL8
3	encephalitis	31.4	TNF IL1B IL10 CCL3
4	poliomyelitis	31.4	TNF IL10 IFNG
5	viral meningitis	31.3	IFNG CXCL8 CRP CALCA ADA
6	rubella	31.2	TNF IL1B IL10 IFNG
7	myelitis	31.1	TNF IL10 CXCL8
8	bacterial meningitis	31.1	TNF IL1B IL10 IFNG CXCL8 CRP
9	herpes zoster	31.0	TNF IL10 IFNG
10	meningoencephalitis	31.0	TNF IL10 CRP
11	acute disseminated encephalomyelitis	30.9	IL1B IL10 CSF3
12	mixed connective tissue disease	30.9	TNF IL10 IFNG
13	haemophilus influenzae	30.8	TNF CXCL8
14	transverse myelitis	30.7	TNF IL10 CXCL8
15	optic neuritis	30.7	TNF IL1B IL10 CXCL8
16	kawasaki disease	30.6	TNF IL1B IL10 CRP
17	allergic disease	30.6	TNF IL1B IL10 IFNG CXCL8
18	purpura	30.6	TNF IL10 IFNG CRP
19	tuberculous meningitis	30.5	TNF CXCL8 CCL3 ADA
20	subacute sclerosing panencephalitis	30.5	TNF IL10 IFNG
21	lyme disease	30.5	TNF IL1B CRP CFI
22	tick-borne encephalitis	30.5	IL10 CXCL13 CCL3
23	pain agnosia	30.5	TNF IL1B CALCA
24	viral encephalitis	30.5	TNF IL1B IL10 CXCL8
25	lymphadenitis	30.5	TNF IL1B IL10 IFNG CXCL8 CRP
26	herpangina	30.4	TNF IL1B IL10 IFNG
27	hepatitis a	30.4	TNF IL1B IL10 IFNG
28	chickenpox	30.4	TNF IL10 IFNG CRP ADA
29	neuritis	30.4	TNF IL1B IL10 IFNG CXCL8 CCL3
30	relapsing polychondritis	30.4	IL10 IFNG CXCL8 CSF3 CRP
31	epidemic typhus	30.3	TNF IL10 CRP
32	common cold	30.3	TNF IL1R1 IL1B IL10 CXCL8
33	cerebritis	30.3	TNF IL1B CRP
34	erythema multiforme	30.3	TNF IFNG CXCL8
35	orchitis	30.3	TNF IL1B IL10 CRP
36	fungal meningitis	30.3	TNF IL10 IFNG CXCL8 CCL3
37	q fever	30.3	TNF IL1R1 IL1B IL10 IFNG
38	myocarditis	30.3	TNF IL1B IL10 IFNG CCL3
39	leptospirosis	30.3	TNF IL1B IL1A IL10 IFNG CXCL8
40	pulmonary sarcoidosis	30.2	TNF IFNG CCL3
41	crohn's colitis	30.2	TNF IL1B IFNG CXCL8
42	exanthem	30.2	TNF NLRP3 IL1B IL10 IFNG CXCL8
43	migraine with or without aura 1	30.2	TNF IL1B IL10 CRP CALCA
44	disease by infectious agent	30.1	TNF IL1RN IL1B IL10 IFNG CRP
45	endocarditis	30.1	TNF IL1A IL10 IFNG CXCL8 CRP
46	rheumatic fever	30.1	TNF IL1A IL10 IFNG
47	tonsillitis	30.1	TNF IL1B IL1A IL10 IFNG CXCL8
48	meningitis	30.1	TNF NLRP3 IL1B IL1A IL10 IFNG
49	syphilis	30.1	TNF IFNG CRP
50	gastritis	30.1	TNF IL1RN IL1B IL10 CXCL8

Graphical network of the top 20 diseases related to Aseptic Meningitis:

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Symptoms & Phenotypes for Aseptic Meningitis

GenomeRNAi Phenotypes related to Aseptic Meningitis according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.44	CD2 CXCL8 IL10 IL1A IL1B NLRP3
2	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.44	CD2 CXCL8 IL10 IL1B NLRP3 TNF

MGI Mouse Phenotypes related to Aseptic Meningitis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.21	ADA CD44 CFI CSF3 CXCL13 IFNG
2	immune system	MP:0005387	10.2	ADA CD44 CFI CRP CSF3 CXCL13
3	cardiovascular system	MP:0005385	10.14	ADA CD44 CRP IFNG IL10 IL1A
4	integument	MP:0010771	10	CD44 CSF3 IFNG IL10 IL1A IL1B
5	liver/biliary system	MP:0005370	9.76	ADA CD44 IFNG IL10 IL1R1 NLRP3
6	neoplasm	MP:0002006	9.56	CD44 IFNG IL10 IL1A IL1B IL1R1
7	renal/urinary system	MP:0005367	9.23	ADA CD44 CFI CSF3 IFNG IL1R1

Sources

Drugs & Therapeutics for Aseptic Meningitis

Drugs for Aseptic Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Ceftriaxone

Approved

73384-59-5

5479530 5361919

Synonyms:

(6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(methyloxy)imino]acetyl}amino)-3-{[(6-hydroxy-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin-3-yl)thio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamido)-8-oxo-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl)thio)methyl)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7(sup 2)-(Z)-(O-methyloxime), sesquaterhydrate

(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulphanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

104376-79-6

104376-79-6 (di-hydrochloride salt)

73384-59-5

74578-69-1 (di-hydrochloride salt, hemiheptahydrate)

7beta-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-3,4-didehydrocepham-4-carboxylic acid

AC-1592

AC1NUIFE

Anhydrous ceftriaxone sodium

Benaxona

Biotrakson

Boehringer mannheim brand OF ceftriaxone sodium

C06683

C18H18N8O7S3

Cefatriaxone

Cefaxona

Ceftrex

Ceftriaxon

Ceftriaxon curamed

Ceftriaxon hexal

Ceftriaxona

Ceftriaxona [INN-Spanish]

Ceftriaxona andreu

Ceftriaxona LDP torlan

ceftriaxone

Ceftriaxone

Ceftriaxone (INN)

Ceftriaxone (TN)

Ceftriaxone [USAN:JAN]

Ceftriaxone intravenous

Ceftriaxone irex

Ceftriaxone sodium

CEFTRIAXONE SODIUM

Ceftriaxone sodium, anhydrous

Ceftriaxone, disodium salt

Ceftriaxone, Disodium Salt

Ceftriaxone, disodium salt, hemiheptahydrate

Ceftriaxone, Disodium Salt, Hemiheptahydrate

Ceftriaxonum

Ceftriaxonum [INN-Latin]

Ceftriazone

CHEBI:29007

CHEMBL161

CID5479530

Columbia brand OF ceftriaxone

CTRX

Curamed brand OF ceftriaxone sodium

D07659

DB01212

DRG-0071

EINECS 277-405-6

Fustery brand OF ceftriaxone sodium

Galen brand OF ceftriaxone sodium

Hexal brand OF ceftriaxone sodium

Hoffman la roche brand OF ceftriaxone sodium

Hoffman-la roche brand OF ceftriaxone sodium

Inibsa brand OF ceftriaxone sodium

Irex brand OF ceftriaxone

Lendacin

Longacef

Longaceph

LS-150031

MolPort-005-933-495

Pisa brand OF ceftriaxone sodium

Ro 139904

Ro13-9904

Ro-13-9904

Rocefalin

Rocefin

Rocephin

Rocephine

Roche brand OF ceftriaxone sodium

Sodium, ceftriaxone

Syntex brand OF ceftriaxone sodium

Tacex

Terbac

UNII-75J73V1629

Acyclovir

Approved

59277-89-3

2022

Synonyms:

1pwy

2-Amino-1,9-dihydro-9-((2-hydroxyethoxy)methyl)-6H-purin-6-one

2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one

2-Amino-9-(2-hydroxy-ethoxymethyl)-1,9-dihydro-purin-6-one

2-amino-9-(2-hydroxyethoxymethyl)-3H-purin-6-one

2-Amino-9-[(2-hydroxyethoxy)methyl]-1,9-dihydro-6H-purin-6-one

2-amino-9-{[(2-hydroxyethyl)oxy]methyl}-1,9-dihydro-6H-purin-6-one

59277-89-3

6H-Purin-6-one,2-amino-1,9-dihydro-9-((2-hydroxyethoxy)mehtyl)

9-((2-Hydroxyethoxy)methyl)guanine

9-(2-Hydroxyethoxy)methylguanine

9-[(2-Hydroxyethoxy)- methyl]guanine

9-[(2-Hydroxyethoxy)methyl]guanine

9-[(2-Hydroxyethoxy)-methyl]guanine

9-Hyroxyethoxymethylguanine

9-HYROXYETHOXYMETHYLGUANINE

A 4669

A1562_SIGMA

A4669_SIGMA

Abello brand OF aciclovir

AC-11038

AC1L1CR6

AC2

Aci sanorania

Acic

Aciclobeta

Aciclostad

Aciclovier

Aciclovir

Aciclovir (JAN/INN)

Aciclovir abello brand

Aciclovir alcon brand

Aciclovir alonga

Aciclovir alphapharm brand

Aciclovir amrad brand

Aciclovir azupharma brand

Aciclovir betapharm brand

Aciclovir britisfarma brand

Aciclovir clonmel brand

Aciclovir CT-arzneimittel brand

Aciclovir dermapharm brand

Aciclovir fabrigen brand

Aciclovir fustery brand

Aciclovir granules

Aciclovir grin brand

Aciclovir grünenthal brand

Aciclovir hexal brand

Aciclovir isis brand

Aciclovir kendrick brand

Aciclovir lichtenstein brand

Aciclovir liomont brand

Aciclovir mann brand

Aciclovir menarini brand

Aciclovir niddapharm brand

Aciclovir novag brand

Aciclovir novartis brand

Aciclovir ophthalmic oinment

Aciclovir pensa brand

Aciclovir pisa brand

Aciclovir rentschler brand

Aciclovir sanorania

Aciclovir sanorania brand

Aciclovir stada brand

Aciclovir tablets

Aciclovir tad brand

Aciclovir ursapharm brand

Aciclovir von CT

Aciclovir warner-lambert brand

Aciclovir wellcome brand

Aciclovir wolff brand

Aciclovir yamanouchi brand

Aciclovir zyma brand

Aciclovir, Acycloguanosine, Zovirax, Acyclovir

Aciclovir-sanorania

Aciclovirum

Aciclovirum [INN-Latin]

Aciclovirum [Latin]

Acifur

Acipen solutab

Aci-sanorania

Acivir

Activir

ACV & Pluronic F-68

Acyclo V

AcycloFoam

Acycloguanosine

Acyclo-V

acyclovir

Acyclovir

Acyclovir & Pluronic F-68

Acyclovir (USP)

Acyclovir [USAN]

Acyclovir Lauriad

Acyclovir sodium

Acyclovir-side chain-2-3H

AKOS000656213

Alcon brand OF aciclovir

Alonga brand OF aciclovir

Alonga brand OF aciclovir sodium salt

Alonga, aciclovir

Alphapharm brand OF aciclovir

Alti-Acyclovir

Amrad brand OF aciclovir

Antiherpes creme

Avirax

Azupharma brand OF aciclovir

BAS 00485787

BB_NC-0569

Betapharm brand OF aciclovir

BIDD:GT0646

B-LF& ACV

Bovine lactoferrin & 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one

BPBio1_000014

Britisfarma brand OF aciclovir

Britisfarma brand OF aciclovir sodium salt

BSPBio_000012

BSPBio_003348

Bull brand OF aciclovir

BW-248U

BW-248-U

BW-248U74

C06810

C8H11N5O3

CAS-59277-89-3

CCRIS 1953

CHEBI:2453

CHEMBL184

Cicloferon

CID2022

Clonmel brand OF aciclovir

Clonorax

CPD000058225

CT Arzneimittel brand OF aciclovir

CT-Arzneimittel brand OF aciclovir

Curasan brand OF aciclovir sodium salt

Cusiviral

D00222

DB00787

Dermapharm brand OF aciclovir

DivK1c_000185

DRG-0008

EINECS 261-685-1

EU-0100037

Fabrigen brand OF aciclovir

FT-0082883

Fustery brand OF aciclovir

Genvir

Glaxo wellcome brand OF aciclovir

Glaxo wellcome brand OF aciclovir sodium salt

Grin brand OF aciclovir

Grünenthal brand OF aciclovir

Grünenthal brand OF aciclovir sodium salt

Hascovir

Herpetad

Herpofug

Herpotern

Herpoviric

Hexal brand OF aciclovir

Hexal brand OF aciclovir sodium salt

HMS1568A14

HMS1922E08

HMS2090G09

HMS500J07

HSDB 6511

I01-1122

IDI1_000185

InChI=1/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15

Isavir

Isis brand OF aciclovir

KBio1_000185

KBio2_002219

KBio2_004787

KBio2_007355

KBio3_002850

KBioGR_000889

KBioSS_002219

Kendrick brand OF aciclovir

Laciken

Lichtenstein brand OF aciclovir

Liomont brand OF aciclovir

Lopac0_000037

Lopac-A-4669

LS-127209

Mann brand OF aciclovir

Mapox

Maynar

Menarini brand OF aciclovir

Menarini brand OF aciclovir sodium salt

Milavir

MLS000069633

MolPort-000-768-994

MolPort-001-889-834

NCGC00015061-01

NCGC00015061-02

NCGC00015061-03

NCGC00015061-04

NCGC00015061-10

NCGC00022426-03

NCGC00093555-01

NCGC00093555-02

NCGC00093555-03

NCGC00093555-04

NCGC00167756-01

Niddapharm brand OF aciclovir

NINDS_000185

Novag brand OF aciclovir

Novartis brand OF aciclovir

NSC 645011

NSC645011

Opthavir

Parke davis brand OF aciclovir

Pensa brand OF aciclovir

Pensa brand OF aciclovir sodium salt

Pharma investi brand OF aciclovir

Pisa brand OF aciclovir

Prestwick_6

Prestwick0_000086

Prestwick1_000086

Prestwick2_000086

Prestwick3_000086

Rentschler brand OF aciclovir

Rentschler brand OF aciclovir sodium salt

S1807_Selleck

SAM002589967

Sanorania brand OF aciclovir

Sanorania brand OF aciclovir sodium salt

Sitavig

SMP1_000007

SMR000058225

Sodium, acyclovir

Solutab, acipen

SPBio_001466

SPBio_001951

Spectrum_001739

SPECTRUM1503603

Spectrum2_001563

Spectrum3_001874

Spectrum4_000225

Spectrum5_001093

Stada brand OF aciclovir

STK796771

Supraviran

TAD brand OF aciclovir

TL8003779

UNII-X4HES1O11F

Ursapharm brand OF aciclovir

Viclovir

Vipral

Virax puren

Virax-puren

ViraxPuren

Virherpes

Virmen

Virolex

Viropump

Virorax

Virupos

Virzin

W-248-U

Warner lambert brand OF aciclovir

Warner wellcome brand OF aciclovir

Warner-lambert brand OF aciclovir

Wellcome 248u

Wellcome brand OF aciclovir

Wellcome brand OF aciclovir sodium salt

Wellcome248u

Wellcome-248u

Wellcome-248U

Wolff brand OF aciclovir

Yamanouchi brand OF aciclovir

ZINC01530555

Zoliparin

Zovir

Zovirax

Zovirax (TN)

Zovirax for injection

Zovirax Oral Acyclovir (ACV) Suspension

Zyclir

Zyma brand OF aciclovir

Thiethylperazine

Approved, Withdrawn

1420-55-9

5440

Synonyms:

10H-Phenothiazine, 2-(ethylthio)-10-[3-(4-methyl-1-piperazinyl)propyl]-, (Z)-2-butenedioate (1:2)

1179-69-7 (maleate (1:2))

1420-55-9

2-(ethylsulfanyl)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine

2-(Ethylthio)-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine

2-(ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine

2-(Ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine

2-ethylsulfanyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine

3-Ethylmercapto-10-(1'-methylpiperazinyl-4'-propyl)phenothiazine

52239-63-1 (malate (1:2))

AB00514742

AC1L1KCZ

C07132

C22H29N3S2

CHEBI:9544

CHEMBL1378

CID5440

D02354

DB00372

EINECS 215-819-0

Ethylthioperazine

ETHYLTHIOPERAZINE

GS-95 (*Dimaleate*)

HSDB 3400

L000871

LS-105543

Norzine

Norzine (*Dimaleate*)

Novartis brand OF thiethlperazine

Novartis brand OF thiethlperazine maleate

NSC130044

Purdue frederick brand OF thiethlperazine

Roxane brand OF thiethlperazine maleate

Theithylperazine

Thiethlperazine novartis brand

Thiethylperazin

thiethylperazine

Thiethylperazine

Thiéthylpérazine

Thiethylperazine (USAN/INN)

Thiethylperazine [USAN:INN:BAN]

Thiethylperazine malate

Thiethylperazine maleate (2:1)

Thiethylperazinum

Thiethylperazinum [INN-Latin]

Thiethylpipezazine

Thioethylperazine

Tietilperazina

Tietilperazina [DCIT]

Torecan

UNII-8ETK1WAF6R

Doxycycline

Approved, Investigational, Vet_approved

564-25-0

54671203

Synonyms:

(2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

(2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

(2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

(2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

(4S,4AR,5S,5ar,6R,12as)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

10597-92-9

17086-28-1 (mono-hydrate)

24390-14-5

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS)

41411-66-9 (6-epimer, mono-hydrochloride)

564-25-0

5-Hydroxy-a-6-deoxytetracycline

5-Hydroxy-alpha-6-deoxytetracycline

5-hydroxy-α-6-deoxytetracycline

5-Hydroxy-α-6-deoxytetracycline

69935-17-7 (mono-hydrochloride, di-hydrate)

6a-Deoxy-5-oxytetracycline

6alpha-deoxy-5-oxytetracycline

6-alpha-deoxy-5-oxytetracycline

6alpha-Deoxy-5-oxytetracycline

6-alpha-Deoxy-5-oxytetracycline

6-Deoxyoxytetracycline

6-Deoxytetracycline

6α-deoxy-5-oxytetracycline

6Α-deoxy-5-oxytetracycline

7164-70-7

7264-10-0

94088-85-4 (calcium salt (1:2))

AB08 (*Fosfatex)

AC1NQXW7

AC1NS4CW

AC1NUYS8

AC1O8PYM

alpha-6-Deoxy-5-hydroxytetracycline

alpha-6-Deoxyoxytetracycline

alpha-Doxycycline

Alti-Doxycycline

Anhydrous doxycycline

Apo-Doxy

Atridox

Azudoxat

BCBcMAP01_000024

BIDD:GT0146

BMY-28689

BPBio1_000951

BSPBio_000863

BSPBio_001936

BU-3839T

C06973

CHEBI:50845

CHEMBL1433

CID5281011

CID5353597

CID5463943

CID6713981

CPD001550033

D07876

DB00254

Deoxymykoin

DivK1c_000345

DMSC (*Fosfatex)

Dossiciclina

Dossiciclina [DCIT]

Doxcycline anhydrous

DOXCYCLINE ANHYDROUS

Doxiciclina

Doxiciclina [INN-Spanish]

Doxiciclina [Italian]

Doxitard

Doxivetin

DOXY

Doxy-Caps

Doxycen

Doxychel

Doxychel (TN)

Doxycin

Doxycyclin

doxycycline

Doxycycline

Doxycycline (200mg/day) or Placebo

Doxycycline (anhydrous)

Doxycycline (INN)

Doxycycline (internal use)

Doxycycline (TN)

Doxycycline anhydrous

DOXYCYCLINE CALCIUM

Doxycycline hyclate

Doxycycline monohydrate

DOXYCYCLINE MONOHYDRATE

Doxycycline-Chinoin

Doxycyclinum

Doxycyclinum [INN-Latin]

Doxy-Puren

Doxysol

Doxy-Tabs

Doxytec

Doxytetracycline

EINECS 209-271-1

GS-3065 (*monohydrate)

HMS2090E06

HSDB 3071

Hydramycin

IDI1_000345

Investin

Jenacyclin

KBio1_000345

KBio2_001287

KBio2_003855

KBio2_006423

KBio3_001156

KBioGR_001133

KBioSS_001287

Liviatin

Lopac0_000405

LS-187766

LS-93868

MolPort-002-507-423

Monodox

Monodox (*monohydrate)

NCGC00161602-01

NCGC00161602-03

NCGC00161602-04

NCGC00167961-01

NCGC00179395-01

NINDS_000345

Novo-Doxylin

NSC633557

Nu-Doxycycline

Oracea

Prestwick0_000852

Prestwick1_000852

Prestwick2_000852

Prestwick3_000852

Ronaxan

SAM002589932

SMP1_000107

Spanor

SPBio_000246

SPBio_002784

Spectrum_000807

Spectrum2_000143

Spectrum3_000408

Spectrum4_000527

Spectrum5_000947

STOCK1N-34341

Supracyclin

UNII-334895S862

UPCMLD-DP021

UPCMLD-DP021:001

Vibramycin

Vibramycin (*monohydrate)

Vibramycin Novum

Vibramycine

Vibra-tabs

Vibravenos

Vivox (*Hyclate)

Lamotrigine

Approved, Investigational

84057-84-1

3878

Synonyms:

3,5-diamino-6-(2,3-dichlorophenyl)- as -triazine

3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine

3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine

3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine

6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine

6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diyldiamine

84057-84-1

AC-10298

AC1L1GWT

BIDD:GT0794

Bio-0056

BW 430C

BW-430C

C047781

CHEBI:138727

CHEBI:6367

CHEMBL741

CID3878

CPD000058464

Crisomet

D00354

DB00555

Desitin Brand of Lamotrigine

EINECS 281-901-8

EU-0100688

EUR-1048

Faes Brand of Lamotrigine

GI 267119X

Glaxo Wellcome Brand of Lamotrigine

GlaxoSmithKline Brand of Lamotrigine

GW 273293

HMS2051C10

HMS2089M08

HMS2093P21

HSDB 7526

Juste Brand of Lamotrigine

L 3791

L3791_SIGMA

Labileno

Lamictal

Lamictal (TN)

Lamictal Cd

Lamictal CD

Lamictal ODT

Lamictal XR

Lamictin

Lamiktal

Lamitor

Lamotrigina

Lamotrigina [Spanish]

lamotrigine

Lamotrigine

Lamotrigine (JAN/USAN/INN)

Lamotrigine [USAN:INN:BAN]

Lamotriginum

Lamotriginum [Latin]

Lopac0_000688

Lopac-L-3791

LS-155249

MLS000069685

MLS000759486

MLS001077325

MolPort-003-666-744

NCGC00015605-01

NCGC00015605-02

NCGC00015605-06

NCGC00015605-08

NCGC00022936-02

NCGC00022936-04

NCGC00022936-05

NSC746307

SAM001246697

SMP2_000303

SMR000058464

STK628377

Tocris-1611

UNII-U3H27498KS

ZINC00013156

Antibiotics, Antitubercular

Antiemetics

Antimalarials

Antiparasitic Agents

Anti-Bacterial Agents

Anti-Infective Agents

dipyrone

522325

Antiviral Agents

Antipyretics

Antiprotozoal Agents

Psychotropic Drugs

Sodium Channel Blockers

Anticonvulsants

Diuretics, Potassium Sparing

Hormones

Antipsychotic Agents

calcium channel blockers

Calcium, Dietary

Calcium

Nutraceutical

7440-70-2

271

Synonyms:

Ca(2+)

Ca2+

Calcio

Calcium

Calcium element

CALCIUM ion

Calcium(2+)

Calcium, doubly charged positive ion

Calcium, elemental

Elemental calcium

Kalzium

Interventional clinical trials:

#	Name	Status	NCT ID	Drugs
1	Prospective Study of the Etiology, Pathogenesis, Clinical Picture and Outcome of Aseptic Meningitis in Slovenia	Unknown status	NCT02328469	symptomatic therapy;Ceftriaxone or Doxycycline;Acyclovir
2	WEUSKOP6166: Prevalence of Aseptic Meningitis Among Lamotrigine Users	Completed	NCT01657864	Lamotrigine
3	Danish Study Group of Infections of the Brain: A Nationwide Prospective Observational Cohort Study of All Central Nervous System Infections in Adults at Departments of Infectious Diseases in Denmark	Recruiting	NCT03418441
4	A Comparison Between a New Experimental Enzymatic Assay to Real Time PCR for the Diagnosing of Central Nervous System Enteroviral Infection	Withdrawn	NCT00864903

Search NIH Clinical Center for Aseptic Meningitis

Cochrane evidence based reviews: meningitis, aseptic

Sources

Genetic Tests for Aseptic Meningitis

Sources

Anatomical Context for Aseptic Meningitis

MalaCards organs/tissues related to Aseptic Meningitis:

⁴⁰

Spinal Cord, Brain, Pituitary, Skin, Kidney, T Cells, Lymph Node

Sources

Publications for Aseptic Meningitis

Articles related to Aseptic Meningitis:

(show top 50) (show all 3291)

#	Title	Authors	PMID	Year
1	Cerebrospinal creatinine kinase level in children with meningitis. ⁵⁴ ⁶¹	Tamimi W...Alharbi KK	18501707	2008
2	The anesthetic management of children with neonatal-onset multi-system inflammatory disease. ⁶¹ ⁵⁴	Lauro CF...Quezado ZM	17646489	2007
3	beta-Glucuronidase activity in cerebrospinal fluid pleocytosis due to urinary tract infection. ⁵⁴ ⁶¹	Eliopoulou M...Beratis N	17577341	2007
4	Cerebrospinal fluid adenosine deaminase activity for the diagnosis of tuberculous meningitis in adults. ⁵⁴ ⁶¹	Chotmongkol V...Yodwut C	17333738	2006
5	[Aseptic meningitis with elevated adenosine deaminase (ADA) after interruption of antiretroviral treatment]. ⁵⁴ ⁶¹	Sorli L...Knobel H	16545326	2006
6	Interleukin-1 beta and interleukin-1 receptor antagonist levels in cerebrospinal fluid of aseptic meningitis patients. ⁶¹ ⁵⁴	Yokoyama T...Seino Y	9677604	1998
7	The production of macrophage inflammatory protein-1alpha in the cerebrospinal fluid at the initial stage of meningitis in children. ⁶¹ ⁵⁴	Inaba Y...Shimbo T	9396559	1997
8	High levels of adenosine deaminase in patients with aseptic meningitis. ⁵⁴ ⁶¹	Alguacil GF...de Paco M	9402416	1997
9	The production of IL-8 in cerebrospinal fluid in aseptic meningitis of children. ⁶¹ ⁵⁴	Ishiguro A...Shimbo T	9328117	1997
10	Increased activity of lysosomal acid hydrolases in the cell-free cerebrospinal fluid of bacterial meningitis. ⁶¹ ⁵⁴	Beratis NG...Syrogiannopoulos GA	9029645	1997
11	Increased creatine kinase brain isoenzyme concentration in cerebrospinal fluid with meningitis. ⁵⁴ ⁶¹	Nussinovitch M...Nussinovitch A	8829004	1996
12	Elevated cerebrospinal fluid levels of manganese superoxide dismutase in bacterial meningitis. ⁵⁴ ⁶¹	Hirose Y...Kato K	7561947	1995
13	Adenosine deaminase activity in the CSF of patients with aseptic meningitis: utility in the diagnosis of tuberculous meningitis or neurobrucellosis. ⁶¹ ⁵⁴	Lopez-Cortes LF...Castillo J	7756471	1995
14	[The significance of elevated Mn SOD level in cerebrospinal fluid of patients with bacterial meningitis--its relation to cytokine]. ⁶¹ ⁵⁴	Hirose Y...Kato K	8026125	1994
15	Shedding of CD9 antigen into cerebrospinal fluid by acute lymphoblastic leukemia cells. ⁵⁴ ⁶¹	Komada Y...Sakurai M	2364164	1990
16	Human liver-expressed antimicrobial peptide 2 elevation in the cerebrospinal fluid in bacterial meningitis. ⁶¹	Sakai K...Nakazato M	33811478	2021
17	Development of carpal tunnel syndrome in association with checkpoint inhibitors. ⁶¹	Eisenbud L...Mar N	32819198	2021
18	Neurotoxicities associated with immune checkpoint inhibitor therapy. ⁶¹	Duong SL...Baehring JM	33454891	2021
19	Validation of the Rule of 7's for Identifying Children at Low-risk for Lyme Meningitis. ⁶¹	Garro A...for Pedi Lyme Net	33710975	2021
20	High Heterogeneity of Echoviruses in Brazilian Children with Acute Gastroenteritis. ⁶¹	do Socorro Foro Ramos E...Leal E	33807396	2021
21	Severity of parechovirus infections in infants under 3 months of age and comparison with enterovirus infections: A French retrospective study. ⁶¹	Marchand S...Coste-Burel M	33773893	2021
22	Outbreak of Enterovirus Infection with Neurological Presentations in a Pediatric Population in Northern Spain: A Clinical Observational Study. ⁶¹	Hedrera-Fernandez A...Malaga I	33657631	2021
23	Accuracy of cerebrospinal fluid ferritin for purulent meningitis. ⁶¹	Garcia PCR...Branco RG	32111595	2021
24	Xanthochromia: yellow color is a red flag. ⁶¹	Hashiyama T...Tsuruyama Y	33711159	2021
25	Surveillance for West Nile Virus Disease - United States, 2009-2018. ⁶¹	McDonald E...Lindsey NP	33661868	2021
26	Aseptic meningitis in rheumatoid arthritis after anti-TNF administration: a case-based literature review. ⁶¹	Yildirim R...Korkmaz C	33751192	2021
27	Neuroradiology of infectious diseases. ⁶¹	Singh SK...Hasbun R	33741796	2021
28	Molecular epidemiology of enteroviruses and predominance of echovirus 30 in an Iranian population with aseptic meningitis. ⁶¹	Farshadpour F...Taherkhani R	33788142	2021
29	Cranial fat dissemination following fat grafting for lumbar dural tear: First case report in the literature. ⁶¹	Alhendawy I...Homapour B	33773369	2021
30	Clinical utility of the FilmArray meningitis/encephalitis panel in children at a tertiary center in South Korea. ⁶¹	Park SE...Lee YJ	32893079	2021
31	Flexible derivative time-varying model in matched case-crossover studies for a small number of geographical locations among the participants. ⁶¹	Ortega-Villa AM...Kim I	33146582	2021
32	Cerebrospinal fluid changes and clinical features of aseptic meningitis in patients with Kawasaki disease. ⁶¹	Hu F...Zhou K	33530798	2021
33	Varicella zoster meningitis in a pregnant woman with uncontrolled type 1 diabetes mellitus. ⁶¹	Mroue L...Gonik B	33622740	2021
34	Persistent aseptic meningitis in a child-think patch. ⁶¹	Nourkami-Tutdibi N...Meyer S	32651688	2021
35	The first two cases of neurotoxocariasis in Taiwan. ⁶¹	Lee KP...Fan CK	33593692	2021
36	Transforaminal intrathecal delivery of nusinersen for older children and adults with spinal muscular atrophy and complex spinal anatomy: an analysis of 200 consecutive injections. ⁶¹	Weaver JJ...Monroe EJ	32471828	2021
37	Environmental Surveillance through Next-Generation Sequencing to Unveil the Diversity of Human Enteroviruses beyond the Reported Clinical Cases. ⁶¹	Lizasoain A...Colina R	33477302	2021
38	Neuro-Behçet Disease in the Central University Hospital of Asturias. ⁶¹	Charca-Benavente LC...Colunga-Arguelles D	31078455	2021
39	Polymerase chain reaction targeting 16S ribosomal RNA for the diagnosis of bacterial meningitis after neurosurgery. ⁶¹	Perdigao Neto LV...Levin AS	33503188	2021
40	A case of cryopyrin-associated periodic fever syndrome during canakinumab administration complicated by inflammatory bowel disease. ⁶¹	Yamasaki Y...Kawano Y	32623652	2021
41	2019 Diagnostic criteria for mixed connective tissue disease (MCTD): From the Japan research committee of the ministry of health, labor, and welfare for systemic autoimmune diseases. ⁶¹	Tanaka Y...Mori M	31903831	2021
42	[Distinctive Disease Entity of Neurological Adverse Events Associated with Immune Checkpoint Inhibitors]. ⁶¹	Seki M...Suzuki S	33361512	2021
43	[Treatment of syringomyelia in patients with arachnopathy within craniovertebral junction]. ⁶¹	Zuev AA...Kostenko GV	33560616	2021
44	Close the gap for routine mumps vaccination in Japan. ⁶¹	Kitano T	32530735	2021
45	Immunogenicity and Safety of KM-248, a Combined Measles, Mumps, and Rubella vaccine, and the Noninferiority to a Measles Vaccine in Healthy Japanese Children; Phase 3 Randomized Multicenter Single-Blind Clinical Trial. ⁶¹	Platt H...Ueda K	33518626	2021
46	Is cerebrospinal fluid lactate useful in differentiating scrub typhus meningitis from aseptic, bacterial and tuberculous meningitis? ⁶¹	Arora S...Yesudass P	33259753	2021
47	Bilateral symmetrical deep gray matter involvement and leptomeningeal enhancement in a child with MOG-IgG-associated encephalomyelitis. ⁶¹	Shen W...Shen Y	33419414	2021
48	Neuro-Ophthalmic Manifestations of Mollaret Meningitis. ⁶¹	Park B...Lee AG	33417418	2021
49	MOG antibody syndrome presenting as aseptic meningitis: an evolving spectrum. ⁶¹	Vibha D...Tripathi M	32632636	2021
50	Recurrent Aseptic Meningitis Associated with Kikuchi's Disease (Histiocytic Necrotizing Lymphadenitis): A Case Report and Literature Review. ⁶¹	Sekiguchi S...Matsumura M	33431735	2021

Sources

Genes for Aseptic Meningitis

Genes related to Aseptic Meningitis (0 elite genes):

(show all 24)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	14.03	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	9677604
2	CCL3	C-C Motif Chemokine Ligand 3	Protein Coding	13.72	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	9328117 9396559
3	IL1B	Interleukin 1 Beta	Protein Coding	13.52	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	13.42	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	TNF	Tumor Necrosis Factor	Protein Coding	13.16	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	IL10	Interleukin 10	Protein Coding	12.59	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	IFNG	Interferon Gamma	Protein Coding	12.58	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	CSF3	Colony Stimulating Factor 3	Protein Coding	12.52	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	IL1RN	Interleukin 1 Receptor Antagonist	Protein Coding	12.43	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	12.31	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	17646489
11	CXCL13	C-X-C Motif Chemokine Ligand 13	Protein Coding	12.22	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	IL1A	Interleukin 1 Alpha	Protein Coding	12.18	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	10.69	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	CD44	CD44 Molecule (Indian Blood Group)	Protein Coding	10.41	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	CD2	CD2 Molecule	Protein Coding	10.29	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	CFI	Complement Factor I	Protein Coding	10.25	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	IL1R2	Interleukin 1 Receptor Type 2	Protein Coding	10.03	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
18	SOD2	Superoxide Dismutase 2	Protein Coding	9.94	Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	8026125 7561947
19	ADA	Adenosine Deaminase	Protein Coding	8.39	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	7756471 16545326 9402416 (more) 17333738
20	CRP	C-Reactive Protein	Protein Coding	6.88	DISEASES inferred ¹⁵
21	CAT	Catalase	Protein Coding	6.85	GeneCards inferred via : Publications (show sections)
22	CD58	CD58 Molecule	Protein Coding	6.85	GeneCards inferred via : Publications (show sections)
23	CSF1	Colony Stimulating Factor 1	Protein Coding	6.85	GeneCards inferred via : Publications (show sections)
24	LTF	Lactotransferrin	Protein Coding	6.85	GeneCards inferred via : Publications (show sections)

Sources

Variations for Aseptic Meningitis

Sources

Expression for Aseptic Meningitis

Search GEO for disease gene expression data for Aseptic Meningitis.

Sources

Pathways for Aseptic Meningitis

Pathways related to Aseptic Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 74)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	14.07	TNF NLRP3 IL1RN IL1R2 IL1R1 IL1B
2	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.9	TNF IL1R2 IL1R1 IL1B IL1A IL10
3	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.64	TNF SOD2 IL1RN IL1R2 IL1R1 IL1B
4	TGF-Beta Pathway ⁶³ Show member pathways JAK-STAT Pathway ⁶³ JNK Pathway ⁶³ MAPK Family Pathway ⁶³ Regulation of eIF4 and p70S6K ⁶³ SOCS Pathway ⁶³	13.61	TNF IL1R1 IL1B IL1A IL10 IFNG
5	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.47	TNF IL1R2 IL1R1 IL1B IL1A IL10
6	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.38	TNF IL1R1 IL1B IL1A IL10 CXCL8
7	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.32	TNF IL1RN IL1R2 IL1R1 IL1B IL1A
8	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Lipid and atherosclerosis ³⁶ Regulation of toll-like receptor signaling pathway ¹	13.29	TNF SOD2 NLRP3 IL1B IL10 IFNG
9	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.95	TNF IL1B IL1A IL10 IFNG CXCL8
10	Measles ³⁶ Show member pathways Epstein-Barr virus infection ³⁶ Influenza A ³⁶	12.92	TNF NLRP3 IL1B IL1A IFNG CXCL8
11	MAPK signaling pathway ³⁶ ¹	12.81	TNF IL1R2 IL1R1 IL1B IL1A
12	Toll-Like receptor Signaling Pathways ⁶⁴ Show member pathways IL-1 Family Signaling Pathways ⁶⁴ Immune response IL-1 signaling pathway ²³ Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²³ Inflammasome Activation Pathways ⁶⁴ Mucin expression in CF via TLRs, EGFR signaling pathways ²³ NOD-like Receptor Signaling Pathways ⁶⁴	12.8	TNF NLRP3 IL1RN IL1R2 IL1R1 IL1B
13	Salmonella infection (KEGG) ³⁶ Show member pathways Pathogenic Escherichia coli infection ³⁶	12.79	TNF NLRP3 IL1R1 IL1B CXCL8
14	NF-KappaB Family Pathway ⁶³ Show member pathways NF-KappaB (p50-p65) Pathway ⁶³	12.76	TNF IL1R2 IL1R1 IL1B IL1A
15	4-1BB Pathway ⁶³ Show member pathways CD27 Pathway ⁶³ CD40 Signaling ⁶³ CMV and MAPK Pathways ⁶³ NF-KappaB Activation by EBV ⁶³ NF-kappaB Activation by Viruses ⁶³ PKR Pathway ⁶³ SUMO Pathway ⁶³ TNFR2 Pathway ⁶³	12.72	TNF IL1R1 IL1B IL1A IFNG
16	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²³ Inflammatory bowel disease ³⁶ Th1 and Th2 cell differentiation ³⁶	12.69	TNF IL1R1 IL1B IL1A IL10 IFNG
17	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.67	TNF IL1B IL1A IL10 IFNG
18	NF-kappaB Signaling ⁴	12.67	TNF IL1RN IL1B IL10 IFNG CD44
19	Shigellosis ³⁶	12.51	TNF NLRP3 IL1R1 IL1B CXCL8 CD44
20	IL-17 Family Signaling Pathways ⁶⁴ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶⁵ Mucin expression in CF via IL-6, IL-17 signaling pathways ²³	12.44	TNF IL1B IFNG CXCL8 CSF3
21	Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions ⁶⁴ Show member pathways Chemokine receptors bind chemokines ⁶⁵ Viral protein interaction with cytokine and cytokine receptor ³⁶	12.44	TNF IL10 CXCL8 CXCL13 CCL3
22	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.44	TNF SOD2 IL1B IFNG CRP
23	Toll Comparative Pathway ⁶³ Show member pathways IL-1 Pathway ⁶³ Immune response MIF in innate immunity response ²³ iNOS Signaling ⁶³ TLR-TRIF Pathway ⁶³	12.42	TNF IL1R1 IL1B IL1A IFNG CXCL8
24	IL-1 signaling pathway ¹ Show member pathways IL1-mediated signaling events ¹ Interleukin-1 signaling ⁶⁵ MAP3K8 (TPL2)-dependent MAPK1/3 activation ⁶⁵ Structural Pathway of Interleukin 1 (IL-1) ¹	12.41	IL1RN IL1R2 IL1R1 IL1B IL1A
25	Toxoplasmosis ³⁶ Show member pathways Leishmaniasis ³⁶	12.36	TNF IL1B IL1A IL10 IFNG
26	Immune response IFN alpha/beta signaling pathway ²³ Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.36	TNF IL1B IL1A IL10 IFNG CXCL8
27	Tuberculosis ³⁶	12.34	TNF IL1B IL1A IL10 IFNG
28	NOD-like receptor signaling pathway ³⁶	12.3	TNF NLRP3 IL1B CXCL8
29	Necroptosis ³⁶ Show member pathways Nanoparticle triggered regulated necrosis ¹	12.3	TNF NLRP3 IL1B IL1A IFNG
30	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.29	TNF IL1RN IL1B IL1A IL10 CXCL8
31	Bacterial infections in CF airways ²³ Show member pathways IL-1 beta-dependent CFTR expression ²³ Immune response Bacterial infections in normal airways ²³ Immune response TLR signaling pathways ²³	12.28	TNF IL1R1 IL1B IFNG CXCL8
32	C-type lectin receptor signaling pathway ³⁶ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁴	12.27	TNF NLRP3 IL1B IL10
33	Fluid shear stress and atherosclerosis ³⁶	12.2	TNF IL1R2 IL1R1 IL1B IL1A IFNG
34	Yersinia infection ³⁶	12.19	TNF NLRP3 IL1B IL10 CXCL8
35	Osteoclast differentiation ³⁶	12.16	TNF IL1R1 IL1B IL1A IFNG
36	MAPK Pathway ⁶⁹ Show member pathways Toll-like Receptor Pathway ⁶⁹	12.12	IL1R2 IL1R1 IL1B IL1A
37	Spinal Cord Injury ¹	12.11	TNF IL1R1 IL1B IL1A IFNG CXCL8
38	Interleukin-4 and 13 signaling ⁶⁵	12.1	TNF IL1B IL1A IL10 CXCL8
39	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	12.09	TNF IL10 IFNG CSF3 CD44 CD2
40	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²³	12.07	IL1R1 IL1B IFNG CCL3
41	NF-kappa B signaling pathway ³⁶	12.03	TNF IL1R1 IL1B CXCL8
42	Senescence and Autophagy in Cancer ¹	12.03	IL1B IL1A IFNG CXCL8 CD44 CCL3
43	AGE-RAGE signaling pathway in diabetic complications ³⁶	12.01	TNF IL1B IL1A CXCL8
44	Rheumatoid arthritis ³⁶	11.94	TNF IL1B IL1A IFNG CXCL8 CCL3
45	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹	11.88	TNF IL1B IL10 IFNG
46	Amoebiasis ³⁶	11.87	TNF IL1R2 IL1R1 IL1B IL10 IFNG
47	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.86	TNF IL1B IL10 IFNG
48	Pertussis ³⁶	11.84	TNF NLRP3 IL1B IL1A IL10 CXCL8
49	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.81	TNF IFNG CXCL8
50	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²³	11.79	TNF IL1B IL1A IFNG CXCL8

Sources

GO Terms for Aseptic Meningitis

Cellular components related to Aseptic Meningitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.8	TNF IL1RN IL1B IL1A IL10 IFNG
2	extracellular region	GO:0005576	9.55	TNF NLRP3 IL1RN IL1R2 IL1R1 IL1B

Biological processes related to Aseptic Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 53)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.32	NLRP3 IL1RN IL1R1 IL1B IL10 CXCL8
2	negative regulation of cell proliferation	GO:0008285	10.09	SOD2 IL1B IL1A IL10 CXCL8
3	cell-cell signaling	GO:0007267	10	IL1B CXCL13 CCL3 CALCA
4	positive regulation of gene expression	GO:0010628	9.98	TNF IL1B IL1A IFNG CXCL8 CRP
5	aging	GO:0007568	9.97	SOD2 IL10 CALCA ADA
6	defense response	GO:0006952	9.94	TNF NLRP3 CXCL8 CXCL13
7	positive regulation of DNA-binding transcription factor activity	GO:0051091	9.89	TNF IL1B IL10 CSF3
8	neutrophil chemotaxis	GO:0030593	9.88	CXCL8 CXCL13 CCL3
9	regulation of insulin secretion	GO:0050796	9.87	TNF IL1B IFNG
10	chemokine-mediated signaling pathway	GO:0070098	9.87	CXCL8 CXCL13 CCL3
11	cellular response to organic cyclic compound	GO:0071407	9.87	TNF IL1B CCL3
12	positive regulation of inflammatory response	GO:0050729	9.87	TNF IL1B IFNG CCL3
13	response to glucocorticoid	GO:0051384	9.86	TNF IL1RN IL10
14	positive regulation of interleukin-6 production	GO:0032755	9.86	TNF IL1B IL1A IFNG
15	cellular response to lipopolysaccharide	GO:0071222	9.86	TNF NLRP3 IL1B IL1A IL10 CXCL8
16	positive regulation of tumor necrosis factor production	GO:0032760	9.85	IL1A IFNG CD2 CCL3
17	cytokine-mediated signaling pathway	GO:0019221	9.85	TNF IL1RN IL1R2 IL1R1 IL1B IL1A
18	positive regulation of phagocytosis	GO:0050766	9.83	TNF IL1B IFNG
19	T cell activation	GO:0042110	9.83	CD44 CD2 ADA
20	interleukin-12-mediated signaling pathway	GO:0035722	9.82	SOD2 IL10 IFNG
21	positive regulation of nitric oxide biosynthetic process	GO:0045429	9.81	TNF IL1B IFNG
22	positive regulation of interferon-gamma production	GO:0032729	9.81	TNF IL1R1 IL1B CD2
23	protein kinase B signaling	GO:0043491	9.8	TNF IL1B CCL3
24	positive regulation of interleukin-8 production	GO:0032757	9.8	TNF IL1B CD2 CALCA
25	interleukin-1-mediated signaling pathway	GO:0070498	9.8	IL1RN IL1R2 IL1R1 IL1B IL1A
26	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	9.79	TNF IL1B IL1A
27	positive regulation of interleukin-1 beta production	GO:0032731	9.78	TNF NLRP3 IFNG CCL3
28	lipopolysaccharide-mediated signaling pathway	GO:0031663	9.77	TNF IL1B CCL3
29	positive regulation of cytokine production	GO:0001819	9.76	TNF IL1A IL10 IFNG
30	immune response	GO:0006955	9.73	TNF IL1RN IL1R2 IL1R1 IL1B IL1A
31	negative regulation of amyloid-beta clearance	GO:1900222	9.71	TNF IFNG
32	positive regulation of MHC class II biosynthetic process	GO:0045348	9.71	IL10 IFNG
33	negative regulation of heterotypic cell-cell adhesion	GO:0034115	9.71	IL1RN IL10
34	response to molecule of bacterial origin	GO:0002237	9.71	IL10 CXCL8
35	embryonic digestive tract development	GO:0048566	9.71	TNF CXCL8 ADA
36	regulation of establishment of endothelial barrier	GO:1903140	9.7	TNF IL1B
37	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	9.7	TNF IL1B IFNG
38	negative regulation of lipid storage	GO:0010888	9.69	TNF CRP
39	endothelial cell apoptotic process	GO:0072577	9.68	TNF IL10
40	negative regulation of interleukin-1-mediated signaling pathway	GO:2000660	9.68	IL1RN IL1R2
41	vascular endothelial growth factor production	GO:0010573	9.68	TNF IL1B
42	negative regulation of cytokine production involved in immune response	GO:0002719	9.67	TNF IL10
43	positive regulation of T-helper 1 cell cytokine production	GO:2000556	9.66	IL1R1 IL1B
44	positive regulation of fever generation	GO:0031622	9.66	TNF IL1B
45	positive regulation of immature T cell proliferation in thymus	GO:0033092	9.63	IL1B IL1A
46	sequestering of triglyceride	GO:0030730	9.63	TNF IL1B
47	positive regulation of heterotypic cell-cell adhesion	GO:0034116	9.62	TNF IL1B IL10 CD44
48	monocyte aggregation	GO:0070487	9.61	IL1B CD44
49	fever generation	GO:0001660	9.61	IL1B IL1A
50	positive regulation of vitamin D biosynthetic process	GO:0060557	9.58	TNF IFNG

Molecular functions related to Aseptic Meningitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:0008009	9.33	CXCL8 CXCL13 CCL3
2	interleukin-1 binding	GO:0019966	9.32	IL1R2 IL1R1
3	cytokine activity	GO:0005125	9.32	TNF IL1RN IL1B IL1A IL10 IFNG
4	interleukin-1 receptor activity	GO:0004908	9.26	IL1R2 IL1R1
5	interleukin-1 receptor binding	GO:0005149	9.13	IL1RN IL1B IL1A

Sources

Sources for Aseptic Meningitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

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⁴¹ MedGen

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⁴⁸ NCBI Bookshelf

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⁵⁴ Novoseek

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⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

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⁶¹ PubMed

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⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia