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MCID: ASP003
MIFTS: 51

Aseptic Meningitis

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Aseptic Meningitis

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MalaCards integrated aliases for Aseptic Meningitis:

Name: Aseptic Meningitis 12 74 3 15 17 71
Acute Aseptic Meningitis 12
Meningitis, Aseptic 43
Meningitis Aseptic 54

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:12157
MeSH 43 D008582
NCIt 49 C118299
SNOMED-CT 67 301770000
ICD10 32 G03.0
UMLS 71 C0025290
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Summaries for Aseptic Meningitis

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CDC : 3 Viral meningitis is the most common type of meningitis, an inflammation of the lining of the brain and spinal cord. It is often less severe than bacterial meningitis, and most people get better on their own (without treatment). However, anyone with symptoms of meningitis should see a doctor right away because some types of meningitis can be very serious. Only a doctor can determine if someone has meningitis, what is causing it, and the best treatment. Babies younger than 1 month old and people with weakened immune systems are more likely to have severe illness from viral meningitis.

MalaCards based summary : Aseptic Meningitis, also known as acute aseptic meningitis, is related to syphilitic meningitis and viral meningitis. An important gene associated with Aseptic Meningitis is IL1R1 (Interleukin 1 Receptor Type 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Tocopherol and Pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spinal cord, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Disease Ontology : 12 A meningitis that is characterized by meningeal inflammation not caused by an identifiable bacterial pathogen in the cerebrospinal fluid. A large majority of them are caused by enteroviruses.

Wikipedia : 74 Aseptic meningitis is the inflammation of the meninges, a membrane covering the brain and spinal cord in... more...

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Related Diseases for Aseptic Meningitis

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Diseases related to Aseptic Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 866)
# Related Disease Score Top Affiliating Genes
1 syphilitic meningitis 32.9 CXCL13 CD40LG
2 viral meningitis 31.6 IFNG CXCL8 CRP CD40LG CALCA ADA
3 poliomyelitis 31.0 TNF IL10 IFNG CD40LG
4 encephalitis 31.0 TNF IL1B IL10 CD40LG CCL3
5 allergic hypersensitivity disease 30.9 TNF IL10 IFNG CXCL8 CCL3
6 haemophilus influenzae 30.9 TNF CXCL8
7 bacterial meningitis 30.9 TNF IL1B IL10 IFNG CXCL8 CRP
8 tuberculous meningitis 30.9 TNF CXCL8 CCL3 ADA
9 mumps 30.9 TNF IL1B IL10 IFNG CXCL8 CD40LG
10 measles 30.9 TNF IL1B IFNG CXCL8 CD40LG
11 transverse myelitis 30.9 TNF IL10 CXCL8
12 rubella 30.8 TNF IL1B IL10 IFNG CD40LG
13 myelitis 30.7 TNF IL10 CXCL8 CD40LG
14 subacute sclerosing panencephalitis 30.6 TNF IL10 IFNG
15 tick-borne encephalitis 30.6 IL10 CXCL13 CCL3
16 mixed connective tissue disease 30.6 TNF IL10 IFNG CD40LG
17 acute disseminated encephalomyelitis 30.6 IL1B IL10 CSF3 CD40LG
18 optic neuritis 30.5 TNF SOD2 IL1B IL10 CXCL8
19 erythema multiforme 30.5 TNF IFNG CXCL8
20 thyroiditis 30.5 TNF IL10 CALCA
21 neuritis 30.5 TNF IL1B IL10 IFNG CXCL8 CCL3
22 common cold 30.4 TNF IL1R1 IL1B IL10 CXCL8
23 hepatitis a 30.4 TNF IL1B IL10 IFNG CXCL8
24 cytomegalovirus infection 30.4 TNF IL1B CXCL8 CCL3
25 crohn's colitis 30.4 TNF IL1B IFNG CXCL8
26 pulmonary sarcoidosis 30.4 TNF IFNG CCL3
27 sapho syndrome 30.3 TNF IL1RN CXCL8 CALCA
28 cysticercosis 30.3 IL1B IL10 CD40LG
29 lymphadenitis 30.3 TNF IL1B IL10 IFNG CXCL8 CRP
30 relapsing polychondritis 30.2 IL10 IFNG CXCL8 CSF3 CRP
31 meningoencephalitis 30.2 TNF IL1B IL10 CRP CD40LG
32 myasthenia gravis 30.2 TNF IL10 IFNG CD40LG
33 gastritis 30.2 TNF IL1RN IL1B IL10 CXCL8
34 tonsillitis 30.2 TNF IL1B IL1A IL10 IFNG CXCL8
35 gastric ulcer 30.2 TNF IL1RN IL1B CXCL8 CALCA
36 herpangina 30.1 TNF IL10 IFNG CD40LG
37 pancreatitis 30.1 TNF IL1B IL10 CRP
38 lyme disease 30.1 TNF IL1B CRP CD40LG
39 histoplasmosis 30.1 TNF IFNG CD40LG
40 influenza 30.0 TNF IL1B IL1A IFNG CXCL8
41 subacute thyroiditis 30.0 TNF IL1B CRP
42 herpes zoster 30.0 TNF IL10 IFNG CRP CD40LG
43 fungal meningitis 30.0 TNF IL10 IFNG CD40LG CCL3
44 uveitis 30.0 TNF IL1R1 IL1B IL1A IL10 IFNG
45 chronic fatigue syndrome 29.9 TNF IL1B IL1A IL10 IFNG CXCL8
46 vasculitis 29.9 TNF IL10 CRP CD40LG
47 sudden infant death syndrome 29.9 TNF IL1RN IL1B IL1A IL10 CXCL8
48 purpura 29.9 TNF IL10 IFNG CRP CD40LG
49 pustulosis of palm and sole 29.9 TNF IL1RN CXCL8 CRP
50 conjunctivitis 29.9 TNF NLRP3 IL10 IFNG CXCL8

Graphical network of the top 20 diseases related to Aseptic Meningitis:



Diseases related to Aseptic Meningitis
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Symptoms & Phenotypes for Aseptic Meningitis

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GenomeRNAi Phenotypes related to Aseptic Meningitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.47 CD2 CD40LG CXCL8 IL10 IL1A IL1B
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.47 CD2 CXCL8 IL10 IL1B NLRP3 TNF

MGI Mouse Phenotypes related to Aseptic Meningitis:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.35 ADA CD40LG CD44 CSF1 CSF3 CXCL13
2 immune system MP:0005387 10.34 ADA CD40LG CD44 CRP CSF1 CSF3
3 cardiovascular system MP:0005385 10.32 ADA CD40LG CD44 CRP CSF1 IFNG
4 homeostasis/metabolism MP:0005376 10.3 ADA CD40LG CD44 CRP CSF1 IFNG
5 cellular MP:0005384 10.27 ADA CD40LG CD44 CSF1 CXCL13 IFNG
6 integument MP:0010771 10.22 CD40LG CD44 CSF1 CSF3 IFNG IL10
7 liver/biliary system MP:0005370 10.02 ADA CD44 CSF1 IFNG IL10 IL1R1
8 muscle MP:0005369 9.92 ADA CD44 CSF1 IFNG IL10 IL1R1
9 neoplasm MP:0002006 9.86 CD44 IFNG IL10 IL1A IL1B IL1R1
10 renal/urinary system MP:0005367 9.76 ADA CD40LG CD44 CSF3 IFNG IL1R1
11 reproductive system MP:0005389 9.65 ADA CD40LG CD44 CSF1 IFNG IL10
12 skeleton MP:0005390 9.36 ADA CD40LG CD44 CSF1 IFNG IL10
Sources

Drugs & Therapeutics for Aseptic Meningitis

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Drugs for Aseptic Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tocopherol Approved, Investigational Phase 3 1406-66-2, 54-28-4 14986
2
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
3
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
4 Tocotrienol Investigational Phase 3 6829-55-6
5 Trace Elements Phase 3
6 Micronutrients Phase 3
7 Vitamins Phase 3
8 Phosphodiesterase Inhibitors Phase 3
9 Antioxidants Phase 3
10 Vasodilator Agents Phase 3
11 Platelet Aggregation Inhibitors Phase 3
12 Nutrients Phase 3
13 Protective Agents Phase 3
14 Radiation-Protective Agents Phase 3
15 Tocotrienols Phase 3
16 Tocopherols Phase 3
17 Antibodies Phase 2
18 Rho(D) Immune Globulin Phase 2
19 Immunoglobulins, Intravenous Phase 2
20 Immunologic Factors Phase 2
21 gamma-Globulins Phase 2
22 Immunoglobulins Phase 2
23 Interleukin 1 Receptor Antagonist Protein Phase 1, Phase 2
24 Antirheumatic Agents Phase 1, Phase 2
25
Acyclovir Approved 59277-89-3 2022
26
Ceftriaxone Approved 73384-59-5 5361919 5479530
27
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
28
Lamotrigine Approved, Investigational 84057-84-1 3878
29 Anti-Infective Agents
30 Antiparasitic Agents
31 Antiviral Agents
32 Antiemetics
33 Anti-Bacterial Agents
34 Antiprotozoal Agents
35
dipyrone 522325
36 Antipyretics
37 Antibiotics, Antitubercular
38 Antimalarials
39 Sodium Channel Blockers
40 Hormones
41 Psychotropic Drugs
42 Anticonvulsants
43 Diuretics, Potassium Sparing
44 Antipsychotic Agents
45 Calcium, Dietary
46 calcium channel blockers
47 Vaccines
48
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Pentoxifylline and Tocopherol (PENTO) in the Treatment of Medication-related Osteonecrosis of the Jaw (MRONJ): A Prospective, Randomized Controlled Trial to Evaluate a Novel Non-operative Treatment Enrolling by invitation NCT03040778 Phase 3 Pentoxifylline;Placebo;Tocopherol
2 Treatment of Idiopathic Thrombocytopenic Purpura in Children With Subcutaneously Administered Anti-D Completed NCT00128882 Phase 2 Anti-D
3 Intravenous Immunoglobulin Therapy for Small Fiber Neuropathy: a Randomized, Double-blind, Placebo-controlled Study on Efficacy and Safety. Completed NCT02637700 Phase 2 Intravenous Immunoglobulin;Placebo
4 A Randomized Double Blind Placebo Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin (IVIG) in Children With Japanese Encephalitis in Nepal Completed NCT01856205 Phase 2 Intravenous immunoglobulin [ImmunoRelâ„¢ (batch 20081217)]
5 A Long-Term Outcome Study With the IL-1 Receptor Antagonist Anakinra/Kineret in Patients With Neonatal Onset Multisystem Inflammatory Disease (NOMID/CINCA Syndrome) A Therapeutic Approach to Study the Pathogenesis of This Disease Terminated NCT00069329 Phase 1, Phase 2 anakinra
6 Prospective Study of the Etiology, Pathogenesis, Clinical Picture and Outcome of Aseptic Meningitis in Slovenia Unknown status NCT02328469 symptomatic therapy;Ceftriaxone or Doxycycline;Acyclovir
7 A Study of Subcutaneous Immunoglobulin as Chronic Treatment for Patients With Chronic Inflammatory Demyelinating Polyneuropathy Unknown status NCT02465359 Immune Globulin Subcutaneous (Human)
8 Long Term Outcomes of EV71 Central Nervous System Infection Unknown status NCT00172393
9 WEUSKOP6166: Prevalence of Aseptic Meningitis Among Lamotrigine Users Completed NCT01657864 Lamotrigine
10 A Phase IV Study to Assess the Safety of Menveo Vaccine Being Used by HMO Subjects Aged 11-21 Years of Age Completed NCT01452464
11 Danish Study Group of Infections of the Brain: A Nationwide Prospective Observational Cohort Study of All Central Nervous System Infections in Adults at Departments of Infectious Diseases in Denmark Recruiting NCT03418441
12 Evaluation of Different Methods for Rapid Diagnosis of Meningitis in Assiut University Hospital Not yet recruiting NCT03759470
13 A Comparison Between a New Experimental Enzymatic Assay to Real Time PCR for the Diagnosing of Central Nervous System Enteroviral Infection Withdrawn NCT00864903

Search NIH Clinical Center for Aseptic Meningitis

Cochrane evidence based reviews: meningitis, aseptic

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Genetic Tests for Aseptic Meningitis

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Anatomical Context for Aseptic Meningitis

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MalaCards organs/tissues related to Aseptic Meningitis:

40
Brain, Testes, Spinal Cord, T Cells, Pituitary, Kidney, Lung
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Publications for Aseptic Meningitis

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Articles related to Aseptic Meningitis:

(show top 50) (show all 3204)
# Title Authors PMID Year
1
Cerebrospinal creatinine kinase level in children with meningitis. 54 61
18501707 2008
2
The anesthetic management of children with neonatal-onset multi-system inflammatory disease. 61 54
17646489 2007
3
beta-Glucuronidase activity in cerebrospinal fluid pleocytosis due to urinary tract infection. 54 61
17577341 2007
4
Cerebrospinal fluid adenosine deaminase activity for the diagnosis of tuberculous meningitis in adults. 54 61
17333738 2006
5
[Aseptic meningitis with elevated adenosine deaminase (ADA) after interruption of antiretroviral treatment]. 54 61
16545326 2006
6
Interleukin-1 beta and interleukin-1 receptor antagonist levels in cerebrospinal fluid of aseptic meningitis patients. 54 61
9677604 1998
7
The production of macrophage inflammatory protein-1alpha in the cerebrospinal fluid at the initial stage of meningitis in children. 54 61
9396559 1997
8
High levels of adenosine deaminase in patients with aseptic meningitis. 54 61
9402416 1997
9
The production of IL-8 in cerebrospinal fluid in aseptic meningitis of children. 61 54
9328117 1997
10
Increased activity of lysosomal acid hydrolases in the cell-free cerebrospinal fluid of bacterial meningitis. 54 61
9029645 1997
11
Increased creatine kinase brain isoenzyme concentration in cerebrospinal fluid with meningitis. 54 61
8829004 1996
12
Elevated cerebrospinal fluid levels of manganese superoxide dismutase in bacterial meningitis. 54 61
7561947 1995
13
Adenosine deaminase activity in the CSF of patients with aseptic meningitis: utility in the diagnosis of tuberculous meningitis or neurobrucellosis. 54 61
7756471 1995
14
[The significance of elevated Mn SOD level in cerebrospinal fluid of patients with bacterial meningitis--its relation to cytokine]. 61 54
8026125 1994
15
Shedding of CD9 antigen into cerebrospinal fluid by acute lymphoblastic leukemia cells. 54 61
2364164 1990
16
Epidemiology of Toscana virus in South Tuscany over the years 2011-2019. 61
32474372 2020
17
Enteric viruses circulating in undiagnosed central nervous system infections at tertiary hospital in São José do Rio Preto, São Paulo, Brazil. 61
32579291 2020
18
A case of CLCN2-related leukoencephalopathy with bright tree appearance during aseptic meningitis. 61
32173090 2020
19
Clinical features of aseptic meningitis with varicella zoster virus infection diagnosed by next-generation sequencing: case reports. 61
32571239 2020
20
Close the gap for routine mumps vaccination in Japan. 61
32530735 2020
21
Incidence and characteristics of neurotoxicity in immune checkpoint inhibitors with focus on neuromuscular events: Experience beyond the clinical trials. 61
32166812 2020
22
Rheumatoid meningitis and infection in absence of rheumatoid arthritis history: review of 31 cases. 61
32519051 2020
23
Distribution of species Enterovirus B in patients with central nervous system infections in São Paulo State, Brazil. 61
32492248 2020
24
A case of recurrent trimethoprim-sulfamethoxazole-induced aseptic meningitis and review of literature
. 61
32567546 2020
25
Aseptic meningitis as an atypical manifestation of neuromyelitis optica spectrum disorder flare. 61
32088653 2020
26
MOG antibody associated demyelinating syndrome presenting as aseptic meningitis in a 6-year-old boy. 61
32200343 2020
27
Kikuchi-Fujimoto disease complicated by aseptic meningitis and hemophagocytosis successfully treated with intrathecal dexamethasone. 61
32577568 2020
28
Interpretation of lumbar cerebrospinal fluid leukocytosis after cranial surgery: The relevance of aseptic meningitis. 61
32331946 2020
29
Drug-induced aseptic meningitis to ibuprofen: The first case confirmed by positive patch test. 61
32034786 2020
30
Transforaminal intrathecal delivery of nusinersen for older children and adults with spinal muscular atrophy and complex spinal anatomy: an analysis of 200 consecutive injections. 61
32471828 2020
31
A hexavalent Coxsackievirus B vaccine is highly immunogenic and has a strong protective capacity in mice and nonhuman primates. 61
32494709 2020
32
Hyaluronidase-Facilitated High-Dose Subcutaneous IgG Effectively Controls Parvovirus B19 Infection in a Pediatric Cardiac Transplant Patient With Severe T-Cell Lymphopenia. 61
32391400 2020
33
Surgical treatment of secondary trigeminal neuralgia induced by cerebellopontine angle tumors: A single-center experience. 61
32492542 2020
34
Cat-scratch Disease in the Pediatric Population: 6 Years of Evaluation and Follow-up in a Public Hospital in Chile. 61
32404788 2020
35
VARICELLA ZOSTER REACTIVATION CAUSING ASEPTIC MENINGITIS IN HEALTHY ADOLESCENTS: A CASE SERIES AND REVIEW OF THE LITERATURE. 61
32467453 2020
36
Intravenous immunoglobulin-induced aseptic meningitis in a patient with Miller Fisher syndrome. 61
32449133 2020
37
Impact of rapid enterovirus polymerase chain reaction testing on management of febrile young infants < 90 days of age with aseptic meningitis. 61
32299396 2020
38
Impact of Immunosuppression on Acute Left Ventricular Function Recovery and ECMO Use in Patients with Fulminant Viral Myocarditis: An "All-In" Strategy. 61
32465972 2020
39
Aseptic meningitis as onset of Kawasaki disease. 61
30654606 2020
40
Vaccines for measles, mumps, rubella, and varicella in children. 61
32309885 2020
41
Comparison of Characteristics of Patients with West Nile Virus or St. Louis Encephalitis Virus Neuroinvasive Disease During Concurrent Outbreaks, Maricopa County, Arizona, 2015. 61
32251616 2020
42
Immunological biomarkers in neuropsychiatric systemic lupus erythematosus: a comparative cross-sectional study from a tertiary care center in South India. 61
32106787 2020
43
Osteosarcoma and Epidermoid Cyst in the Cerebellopontine Angle of an Adult. 61
32305611 2020
44
Acupuncture in the Management of Medication Overuse and Drug-induced Aseptic Meningitis Headache: A Case Report. 61
31953043 2020
45
Incidence and aetiology of serious viral infections in young febrile infants. 61
31729791 2020
46
Acute flaccid paralysis due to Echovirus 30 in an immunosuppressed transplant recipient. 61
31642013 2020
47
Recent advances in the diagnosis of leptospirosis. 61
32114449 2020
48
Cerebrospinal fluid cytokines and chemokines in children with Lyme neuroborreliosis; pattern and diagnostic utility. 61
32199247 2020
49
Acute cerebellar ataxia: a rare Toscana Virus (TOSV) meningoencephalitis complication. 61
31554442 2020
50
Current Status of Mumps Virus Infection: Epidemiology, Pathogenesis, and Vaccine. 61
32150969 2020
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Variations for Aseptic Meningitis

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Expression for Aseptic Meningitis

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Search GEO for disease gene expression data for Aseptic Meningitis.
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Pathways for Aseptic Meningitis

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Pathways related to Aseptic Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.1 TNF NLRP3 IL1RN IL1R1 IL1B IL1A
2
ERK Signaling 63
Show member pathways
 13.92 TNF IL1R1 IL1B IL1A IL10 CXCL8
3
PEDF Induced Signaling 63
Show member pathways
 13.67 TNF SOD2 IL1RN IL1R1 IL1B IL1A
4
TGF-Beta Pathway 63
Show member pathways
 13.62 TNF IL1R1 IL1B IL1A IL10 IFNG
5
Akt Signaling 63
Show member pathways
 13.47 TNF IL1R1 IL1B IL1A IL10 CXCL8
6
PAK Pathway 63
Show member pathways
 13.34 TNF IL1R1 IL1B IL1A IL10 CXCL8
7
Cytokine Signaling in Immune system 65
Show member pathways
 13.33 TNF IL1RN IL1R1 IL1B IL1A IL10
8
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.11 TNF IL1B IL10 IFNG CXCL8 CCL3
9
Allograft rejection 1 36
Show member pathways
 12.96 TNF IL1B IL1A IL10 IFNG CXCL8
10
Measles 36
Show member pathways
 12.94 TNF NLRP3 IL1B IL1A IFNG CXCL8
11
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.84 TNF NLRP3 IL1RN IL1R1 IL1B IL1A
12
MAPK signaling pathway 36 1
12.81 TNF IL1R1 IL1B IL1A CSF1
13
4-1BB Pathway 63
Show member pathways
 12.78 TNF IL1R1 IL1B IL1A IFNG CD40LG
14
NF-KappaB Family Pathway 63
Show member pathways
 12.76 TNF IL1R1 IL1B IL1A CD40LG
15
T cell receptor signaling pathway 36
Show member pathways
 12.72 TNF IL1B IL1A IL10 IFNG CD40LG
16
Th17 cell differentiation 36
Show member pathways
 12.72 TNF IL1R1 IL1B IL1A IL10 IFNG
17
NF-kappaB Signaling 4
12.67 TNF IL1RN IL1B IL10 IFNG CD44
18
TRAF Pathway 63
Show member pathways
 12.66 TNF IL1R1 IL1B IL1A CD40LG
19
Shigellosis 36
12.53 TNF NLRP3 IL1R1 IL1B CXCL8 CD44
20
Toll Comparative Pathway 63
Show member pathways
 12.46 TNF IL1R1 IL1B IL1A IFNG CXCL8
21
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.46 TNF IL10 CXCL8 CXCL13 CSF1 CCL3
22
IL-17 Family Signaling Pathways 64
Show member pathways
 12.45 TNF IL1B IFNG CXCL8 CSF3
23
Folate Metabolism 1
Show member pathways
 12.45 TNF SOD2 IL1B IFNG CSF1 CRP
24
Pathogenic Escherichia coli infection 36
12.39 TNF NLRP3 IL1R1 IL1B CXCL8
25
Toxoplasmosis 36
Show member pathways
 12.39 TNF IL1B IL1A IL10 IFNG CD40LG
26
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.38 TNF IL1B IL1A IL10 IFNG CXCL8
27
Salmonella infection (KEGG) 36
12.36 TNF NLRP3 IL1B CXCL8
28
IL-1 signaling pathway 1
Show member pathways
 12.36 IL1RN IL1R1 IL1B IL1A
29
Tuberculosis 36
12.36 TNF IL1B IL1A IL10 IFNG
30
Necroptosis 36
Show member pathways
 12.33 TNF NLRP3 IL1B IL1A IFNG
31
Bacterial infections in CF airways 22
Show member pathways
 12.31 TNF IL1R1 IL1B IFNG CXCL8
32
NOD-like receptor signaling pathway 36
12.3 TNF NLRP3 IL1B CXCL8
33
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.3 TNF IL1RN IL1B IL1A IL10 CXCL8
34
C-type lectin receptor signaling pathway 36
Show member pathways
 12.27 TNF NLRP3 IL1B IL10
35
Fluid shear stress and atherosclerosis 36
12.23 TNF IL1R1 IL1B IL1A IFNG
36
Osteoclast differentiation 36
12.18 TNF IL1R1 IL1B IL1A IFNG CSF1
37
Yersinia infection 36
12.16 TNF NLRP3 IL1B IL10 CXCL8
38
Spinal Cord Injury 1
12.15 TNF IL1R1 IL1B IL1A IFNG CXCL8
39
Interleukin-4 and 13 signaling 65
12.13 TNF IL1B IL1A IL10 CXCL8
40
Hematopoietic Stem Cells and Lineage-specific Markers 64
12.09 TNF IL10 IFNG CSF3 CSF1 CD44
41
IL12-mediated signaling events 1
Show member pathways
 12.08 IL1R1 IL1B IFNG CCL3
42
Senescence and Autophagy in Cancer 1
12.08 IL1B IL1A IFNG CXCL8 CD44 CCL3
43
NF-kappa B signaling pathway 36
12.07 TNF IL1R1 IL1B CXCL8 CD40LG
44
IL27-mediated signaling events 1
Show member pathways
 12.05 TNF IL1B IL10 IFNG
45
Amoebiasis 36
12.05 TNF IL1R1 IL1B IL10 IFNG CXCL8
46
AGE-RAGE signaling pathway in diabetic complications 36
12.02 TNF IL1B IL1A CXCL8
47
Rheumatoid arthritis 36
11.95 TNF IL1B IL1A IFNG CXCL8 CSF1
48
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.9 TNF IFNG CXCL8 CD40LG
49
Dendritic Cells Developmental Lineage Pathway 64
11.89 TNF IL1B IL10 IFNG CSF1
50
Pertussis 36
11.89 TNF NLRP3 IL1B IL1A IL10 CXCL8
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GO Terms for Aseptic Meningitis

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Cellular components related to Aseptic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.83 TNF IL1RN IL1B IL1A IL10 IFNG
2 external side of plasma membrane GO:0009897 9.65 TNF IL1R1 CD40LG CD2 ADA
3 cell surface GO:0009986 9.63 TNF IL1R1 CD44 CD40LG CD2 ADA
4 extracellular region GO:0005576 9.55 TNF NLRP3 IL1RN IL1R1 IL1B IL1A

Biological processes related to Aseptic Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.22 NLRP3 IL1RN IL1R1 IL1B IL10 CXCL8
2 negative regulation of cell proliferation GO:0008285 10.11 SOD2 IL1B IL1A IL10 CXCL8
3 leukocyte migration GO:0050900 10 TNF IL1B CD44 CD2
4 positive regulation of gene expression GO:0010628 10 TNF IL1B IL1A IFNG CSF1 CRP
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 TNF NLRP3 IL1B CD40LG
6 defense response GO:0006952 9.96 TNF NLRP3 CXCL8 CXCL13
7 positive regulation of DNA-binding transcription factor activity GO:0051091 9.92 TNF IL1B IL10 CSF3
8 chemokine-mediated signaling pathway GO:0070098 9.9 CXCL8 CXCL13 CCL3
9 regulation of insulin secretion GO:0050796 9.89 TNF IL1B IFNG
10 cellular response to organic cyclic compound GO:0071407 9.89 TNF IL1B CCL3
11 response to glucocorticoid GO:0051384 9.89 TNF IL1RN IL10
12 interleukin-1-mediated signaling pathway GO:0070498 9.88 IL1RN IL1R1 IL1B IL1A
13 T cell activation GO:0042110 9.87 CD44 CD2 ADA
14 positive regulation of inflammatory response GO:0050729 9.86 TNF IL1B IFNG CCL3
15 cellular response to lipopolysaccharide GO:0071222 9.86 TNF NLRP3 IL1B IL1A IL10 CXCL8
16 positive regulation of phagocytosis GO:0050766 9.85 TNF IL1B IFNG
17 interleukin-12-mediated signaling pathway GO:0035722 9.85 SOD2 IL10 IFNG
18 neutrophil chemotaxis GO:0030593 9.85 IL1B CXCL8 CXCL13 CCL3
19 cytokine-mediated signaling pathway GO:0019221 9.85 TNF IL1RN IL1R1 IL1B IL1A IL10
20 positive regulation of interferon-gamma production GO:0032729 9.84 TNF IL1R1 IL1B
21 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 TNF IL1B IFNG
22 protein kinase B signaling GO:0043491 9.82 TNF IL1B CCL3
23 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.81 TNF IL1B IL1A
24 lipopolysaccharide-mediated signaling pathway GO:0031663 9.81 TNF IL1B CCL3
25 positive regulation of interleukin-8 production GO:0032757 9.79 TNF IL1B CALCA
26 inflammatory response to antigenic stimulus GO:0002437 9.77 IL1RN IL1B IL1A
27 leukocyte chemotaxis GO:0030595 9.75 IL10 CXCL8 CXCL13
28 positive regulation of osteoclast differentiation GO:0045672 9.74 TNF IFNG CSF1
29 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.73 IL1RN IL10
30 response to molecule of bacterial origin GO:0002237 9.73 IL10 CXCL8
31 negative regulation of amyloid-beta clearance GO:1900222 9.73 TNF IFNG
32 positive regulation of interleukin-6 secretion GO:2000778 9.73 TNF IL1B IL1A IFNG
33 immune response GO:0006955 9.73 TNF IL1RN IL1R1 IL1B IL1A IL10
34 positive regulation of MHC class II biosynthetic process GO:0045348 9.72 IL10 IFNG
35 negative regulation of lipid storage GO:0010888 9.72 TNF CRP
36 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.72 TNF IFNG
37 regulation of establishment of endothelial barrier GO:1903140 9.71 TNF IL1B
38 endothelial cell apoptotic process GO:0072577 9.71 TNF IL10
39 embryonic digestive tract development GO:0048566 9.71 TNF CXCL8 ADA
40 positive regulation of cytokine secretion GO:0050715 9.71 TNF IL1A IL10 IFNG
41 positive regulation of microglial cell migration GO:1904141 9.7 CSF1 CCL3
42 ectopic germ cell programmed cell death GO:0035234 9.7 IL1B IL1A
43 interleukin-1 beta production GO:0032611 9.7 NLRP3 IL1B
44 astrocyte activation GO:0048143 9.7 TNF IL1B IFNG
45 negative regulation of cytokine production involved in immune response GO:0002719 9.69 TNF IL10
46 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.69 IL1R1 IL1B
47 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.69 TNF IL1B IFNG
48 regulation of immunoglobulin secretion GO:0051023 9.68 TNF CD40LG
49 positive regulation of fever generation GO:0031622 9.68 TNF IL1B
50 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 TNF IL10

Molecular functions related to Aseptic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.76 TNF SOD2 NLRP3 CSF1 CRP CD2
2 chemokine activity GO:0008009 9.43 CXCL8 CXCL13 CCL3
3 cytokine activity GO:0005125 9.4 TNF IL1RN IL1B IL1A IL10 IFNG
4 interleukin-1 receptor binding GO:0005149 9.13 IL1RN IL1B IL1A
Sources

Sources for Aseptic Meningitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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