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MCID: ASH001
MIFTS: 30

Asherman's Syndrome

Categories: Rare diseases, Reproductive diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Asherman's Syndrome

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MalaCards integrated aliases for Asherman's Syndrome:

Name: Asherman's Syndrome 54
Asherman Syndrome 54 60 74
Intrauterine Adhesions 60 74
Intrauterine Synechiae 54 60
Adhesions of Uterus 74
Uterine Synechiae 54

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 35
Orphanet: 60  
Rare gynaecological and obstetric diseases


External Ids:

ICD10 via Orphanet 35 N85.6
UMLS via Orphanet 75 C0156372 C0241593 C1704274
Orphanet 60 ORPHA137686
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Summaries for Asherman's Syndrome

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MalaCards based summary : Asherman's Syndrome, also known as asherman syndrome, is related to placenta accreta and amenorrhea. An important gene associated with Asherman's Syndrome is NFKB1 (Nuclear Factor Kappa B Subunit 1). The drugs Hyaluronic acid and Dimenhydrinate have been mentioned in the context of this disorder. Affiliated tissues include uterus, bone and cervix.

Wikipedia : 77 Asherman''s syndrome (AS), which is also referred to as intrauterine adhesions (IUA) or intrauterine... more...

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Related Diseases for Asherman's Syndrome

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Diseases related to Asherman's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 placenta accreta 10.4
2 amenorrhea 10.3
3 infertility 10.3
4 adhesions of uterus 10.2
5 endometrial cancer 10.0
6 schistosomiasis 10.0
7 scoliosis 10.0
8 placenta disease 10.0
9 placenta praevia 10.0
10 endometriosis 10.0
11 endometritis 10.0
12 myoma 9.9
13 hyperglycemia 9.7
14 rapidly involuting congenital hemangioma 9.7

Comorbidity relations with Asherman's Syndrome via Phenotypic Disease Network (PDN):


Myofibroma

Graphical network of the top 20 diseases related to Asherman's Syndrome:



Diseases related to Asherman's Syndrome
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Symptoms & Phenotypes for Asherman's Syndrome

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Drugs & Therapeutics for Asherman's Syndrome

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Drugs for Asherman's Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3 9004-61-9 53477741
2
Dimenhydrinate Approved Phase 4 523-87-5 441281
3
Polyestradiol phosphate Approved Phase 4,Phase 1,Phase 2,Not Applicable 28014-46-2
4
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 50-28-2 5757
5 Pharmaceutical Solutions Phase 4
6 Adjuvants, Immunologic Phase 4,Phase 1,Phase 2,Not Applicable
7 Immunologic Factors Phase 4,Phase 1,Phase 2,Not Applicable
8 Protective Agents Phase 4
9 Carboxymethylcellulose Sodium Phase 4
10 Viscosupplements Phase 4
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
12 Contraceptive Agents Phase 4,Phase 3,Not Applicable
13 Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
14 Hormones Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
15 Estradiol 3-benzoate Phase 4,Phase 1,Phase 2,Not Applicable
16 Progestins Phase 4,Phase 1,Phase 2,Not Applicable
17 Estradiol 17 beta-cypionate Phase 4,Phase 1,Phase 2,Not Applicable
18 Estrogens Phase 4,Phase 1,Phase 2,Not Applicable
19
Mifepristone Approved, Investigational Phase 3 84371-65-3 55245
20
Misoprostol Approved Phase 3 59122-46-2 5282381
21 Contraceptives, Postcoital Phase 3
22 Contraceptives, Oral Phase 3
23 Antacids Phase 3
24 Gastrointestinal Agents Phase 3
25 Anti-Ulcer Agents Phase 3
26 Luteolytic Agents Phase 3
27 Oxytocics Phase 3
28
Lenograstim Approved, Investigational Phase 1, Phase 2,Not Applicable 135968-09-1
29
Sargramostim Approved, Investigational Phase 1, Phase 2,Not Applicable 123774-72-1, 83869-56-1
30 Antibiotics, Antitubercular Phase 2,Phase 1
31 Anesthetics Phase 2,Phase 1
32 Anti-Bacterial Agents Phase 2,Phase 1
33
Copper Approved, Investigational Not Applicable 7440-50-8 27099
34
Medroxyprogesterone acetate Approved, Investigational Not Applicable 71-58-9
35
Progesterone Approved, Vet_approved Not Applicable 57-83-0 5994
36
carbamide peroxide Approved Not Applicable 124-43-6
37 Calamus Not Applicable
38
Medroxyprogesterone Not Applicable 520-85-4 10631

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy Unknown status NCT01632202 Phase 4
2 Bone Marrow Stem Cell Treatment for Asherman's Syndrome and Endometrial Atrophy Completed NCT02144987 Phase 4
3 Estrogen in the Prevention of Adhesion Reformation Enrolling by invitation NCT03620929 Phase 4 Estradiol Valerate
4 Cervical Preparation for Surgical Abortion at 12-14 Weeks: a Prospective, Randomized, Evaluator-blinded, Multicenter, Controlled Comparison Between Mifepristone, Misoprostol and Their Combination Unknown status NCT01795599 Phase 3 Mifegyne ®;Gymiso®
5 Hyaluronic Acid and Uterine Synechiae Active, not recruiting NCT02248376 Phase 3 Gel
6 Platelet-rich Plasma (PRP) for Endometrial Regeneration and Repair Completed NCT02825849 Phase 2
7 Comparison of Different Doses of Oestrogen Therapy for Preventing Intrauterine Adhesion Completed NCT02726971 Phase 1, Phase 2 Femoston
8 Treatment of Severe Asherman Syndrome by Collagen Scaffold Loaded With Autologous Bone Marrow Mononuclear Cells Recruiting NCT02680366 Phase 2
9 Autologous Bone Marrow-derived Mesenchymal Stem Cells for Atrophic Endometrium in Patients With Repeated IVF Failures Active, not recruiting NCT03166189 Phase 2
10 Effect of Colony Stimulating Factor on Poor Endometrial Development During IVF Terminated NCT01202643 Phase 1, Phase 2 G-CSF;Saline
11 Role of Stem Cells in Improving Implantation Rates in ICSI Patients Unknown status NCT01649752 Phase 1
12 Myomectomy During Cesarean Section Completed NCT03095014 Phase 1
13 Human Amniotic Epithelial Cells for Asherman's Syndrome Not yet recruiting NCT03223454 Phase 1
14 Comparing the Efficacy of Intrauterine Balloon and Intrauterine Contraceptive Device for the Therapy of Uterine Adhesion Unknown status NCT02867202 Not Applicable
15 Intrauterine Balloon Therapy to Prevent the Recurrence of Intrauterine Adhesions Unknown status NCT03131596 Not Applicable
16 Efficiency of INTERCOAT (Oxiplex/AP Gel) in Preventing Intrauterine Adhesion Formation in Hysteroscopic Surgery Unknown status NCT01637974 Not Applicable INTERCOAT administration
17 Description of the Uterine Cavity in Patients With Recurrent Miscarriages Unknown status NCT02746588
18 Efficiency of Amnion Graft to Prevent Intrauterine Adhesions After Hysteroscopic Surgery Unknown status NCT02132104 Not Applicable Femoston
19 Efficiency of Intercoat (Oxiplex/AP Gel)in Decreasing Intrauterine Adhesions Completed NCT01377779 Not Applicable Oxiplex/AP gel;Normal Saline
20 Impact of Mindfulness Based Stress Reduction on Anxiety, Depression and QOL in Women With Intrauterine Adhesion. Completed NCT02746679 Not Applicable
21 Intrauterine Adhesion Rate After Hysteroscopic Myomectomy and Application of HYALOBARRIER Gel Completed NCT01412489 Not Applicable
22 Reproductive Outcome Affected by Two Adjunctive Treatments in Patients With Severe Intrauterine Adhesions Completed NCT02708277 Not Applicable
23 The Efficacy and Safety of Disposable Balloon Uterine Stent in Patients With Asherman Syndrome Recruiting NCT03330873 Not Applicable
24 Use of PRP in Endometrial Reconstruction Recruiting NCT03249415
25 Comparing Intra Uterine Synechiae Occurence Using Bipolar Energy Compared With Monopolar Energy in Myoma Resection on Women Having Menorraghia and/or Infertility Recruiting NCT02661087 Not Applicable
26 Comparing the Efficacy of Two Methods for the Therapy of Uterine Adhesion Recruiting NCT03329898 Not Applicable estradiol valerate tablets;dydrogesterone Tablets
27 Comparing the Efficacy of Two Methods in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis Recruiting NCT03346317 Not Applicable estradiol valerate tablets+dydrogesterone tablets
28 The Efficacy of Estrogen Therapy Against Adhesion Reformation After Hysteroscopic Adhesiolysis Recruiting NCT03351205 Not Applicable estradiol valerate tablets+dydrogesterone tablets
29 The Efficacy of G-CSF Against Adhesion Reformation After Hysteroscopic Adhesiolysis Recruiting NCT02855632 Not Applicable G-CSF;Normal saline;hormone therapy
30 Pre-clinical Endometrial Tissular Renovation Study Active, not recruiting NCT03665649 Not Applicable
31 Human Amniotic Epithelial Cell in Treatment of Refractory Severe Intrauterine Adhesion Not yet recruiting NCT03381807 Early Phase 1
32 Development of a Bioabsorbable Medical Device for the Prevention of Postoperative Intra-uterine Adhesions. Withdrawn NCT02328742

Search NIH Clinical Center for Asherman's Syndrome

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Genetic Tests for Asherman's Syndrome

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Anatomical Context for Asherman's Syndrome

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MalaCards organs/tissues related to Asherman's Syndrome:

42
Uterus, Bone, Cervix, Placenta, Bone Marrow
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Publications for Asherman's Syndrome

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Articles related to Asherman's Syndrome:

(show top 50) (show all 128)
# Title Authors Year
1
A cohort study comparing the severity and outcome of intrauterine adhesiolysis for Asherman syndrome after first- or second-trimester termination of pregnancy. ( 31082744 )
2019
2
The efficacy of Ankaferd Blood Stopper® in an experimental Asherman syndrome model created in rats. ( 31019834 )
2019
3
Asherman's syndrome: current perspectives on diagnosis and management. ( 30936754 )
2019
4
Single cell-derived clonally expanded mesenchymal progenitor cells from somatic cell nuclear transfer-derived pluripotent stem cells ameliorate the endometrial function in the uterus of a murine model with Asherman's syndrome. ( 30896075 )
2019
5
Endometrial Regeneration in Asherman's Syndrome: Clinical and Translational evidence of Stem Cell Therapies. ( 30760192 )
2019
6
Reproductive outcomes after surgical treatment of asherman syndrome: A systematic review. ( 30713131 )
2019
7
Bone Marrow Mesenchymal Stem Cells (BMSCs) Restore Functional Endometrium in the Rat Model for Severe Asherman Syndrome. ( 30458678 )
2019
8
Hysteroscopic Management of Asherman's Syndrome. ( 29024798 )
2018
9
The effect of endometrial thickness on pregnancy outcome in patients with Asherman's syndrome post-hysteroscopic adhesiolysis. ( 29483785 )
2018
10
Detection of Asherman's syndrome after conservative management of placenta accreta: a case report. ( 30454053 )
2018
11
Placenta Accreta following Hysteroscopic Lysis of Adhesions Caused by Asherman's Syndrome: A Case Report and Literature Review. ( 29955406 )
2018
12
Live birth rate and obstetric complications following the hysteroscopic management of intrauterine adhesions including Asherman syndrome. ( 30239778 )
2018
13
The birth weight in pregnant women with Asherman syndrome compared to normal intrauterine cavity: A case-control study. ( 30095642 )
2018
14
The association between menstrual cycle pattern and hysteroscopic march classification with endometrial thickness among infertile women with Asherman syndrome. ( 29979403 )
2018
15
Stem cell therapy in Asherman syndrome and thin endometrium: Stem cell- based therapy. ( 29571018 )
2018
16
Clinical and Reproductive Outcomes Following Hysteroscopic Adhesiolysis for Asherman Syndrome in an Asian Population. ( 29493709 )
2018
17
Platelet-rich plasma in the management of Asherman syndrome: case report. ( 29455274 )
2018
18
A comprehensive review of Asherman's syndrome: causes, symptoms and treatment options. ( 28582327 )
2017
19
CXCL12 Promotes Stem Cell Recruitment and Uterine Repair after Injury in Asherman's Syndrome. ( 28345002 )
2017
20
Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome. ( 27921235 )
2017
21
Anti-Mullerian hormone as a parameter for endometrial trauma in Asherman syndrome: A retrospective data analysis. ( 28400095 )
2017
22
Elevated NF-κB signaling in Asherman syndrome patients and animal models. ( 28148903 )
2017
23
Autologous menstrual blood-derived stromal cells transplantation for severe Asherman's syndrome. ( 27664218 )
2016
24
Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman's syndrome and endometrial atrophy: a pilot cohort study. ( 27005892 )
2016
25
Induction of Asherman's Syndrome in Rabbit. ( 26962478 )
2016
26
Management of false passage created during hysteroscopic adhesiolysis for Asherman's syndrome. ( 26207696 )
2016
27
Treatment of Asherman's syndrome in an outpatient hysteroscopy setting. ( 25497164 )
2015
28
Reproductive Outcome of Patients With Asherman's Syndrome After Hysteroscopic Adhesiolysis. ( 27678984 )
2015
29
Treatment of Asherman's Syndrome in an Outpatient Hysteroscopy Setting. ( 27678648 )
2015
30
Reproductive Outcome of Patients with Asherman's Syndrome: A SAIMS Experience. ( 27110522 )
2015
31
A 10-year Review of the Clinical Presentation and Treatment Outcome of Asherman's Syndrome at a Center with Limited Resources. ( 27057384 )
2015
32
Placenta accreta: adherent placenta due to Asherman syndrome. ( 25838908 )
2015
33
Asherman syndrome: an unsolved clinical definition and management. ( 26484781 )
2015
34
Human CD133(+) bone marrow-derived stem cells promote endometrial proliferation in a murine model of Asherman syndrome. ( 26384164 )
2015
35
Secondary amenorrhea in severe Asherman's syndrome: step by step fertility retrieval by Bettocchi's hysteroscope: some considerations. ( 24024657 )
2014
36
Curettage and Asherman's syndrome-lessons to (re-) learn? ( 25574677 )
2014
37
Asherman syndrome in a Danish population. ( 24484072 )
2014
38
Autologous stem cell transplantation in refractory Asherman's syndrome: A novel cell based therapy. ( 25191021 )
2014
39
Use of a hysteroscopic morcellator to resect miscarriage in a woman with recurrent Asherman's syndrome. ( 24865632 )
2014
40
A matched cohort study comparing the outcome of intrauterine adhesiolysis for Asherman's syndrome after uterine artery embolization or surgical trauma. ( 24842805 )
2014
41
Bone Marrow-Derived Stem Cell (BMDSC) transplantation improves fertility in a murine model of Asherman's syndrome. ( 24819371 )
2014
42
A rare case of Asherman's syndrome after open myomectomy: sonographic investigations and possible underlying mechanisms. ( 24557451 )
2014
43
Role of 3D sonohysterography in the investigation of uterine synechiae/asherman's syndrome: pictorial assay. ( 24314038 )
2014
44
Comprehensive treatment for infertile women with severe Asherman syndrome. ( 25286793 )
2014
45
Effect of stem cell application on Asherman syndrome, an experimental rat model. ( 24974357 )
2014
46
The management of Asherman syndrome: a review of literature. ( 24373209 )
2013
47
A comparison of intrauterine balloon, intrauterine contraceptive device and hyaluronic acid gel in the prevention of adhesion reformation following hysteroscopic surgery for Asherman syndrome: a cohort study. ( 23932377 )
2013
48
Hysteroscopic adhesiolysis for patients with Asherman's syndrome: menstrual and fertility outcomes. ( 29662367 )
2013
49
The Diagnosis and Management of Asherman's Syndrome Developed after Cesarean Section and Reproductive Outcome. ( 23840987 )
2013
50
Asherman's syndrome. ( 23600077 )
2013
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Variations for Asherman's Syndrome

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Expression for Asherman's Syndrome

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Search GEO for disease gene expression data for Asherman's Syndrome.
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Pathways for Asherman's Syndrome

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GO Terms for Asherman's Syndrome

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Sources for Asherman's Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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