MCID: ASH001
MIFTS: 31

Asherman's Syndrome

Categories: Rare diseases, Reproductive diseases

Aliases & Classifications for Asherman's Syndrome

MalaCards integrated aliases for Asherman's Syndrome:

Name: Asherman's Syndrome 52
Asherman Syndrome 52 58 71
Intrauterine Adhesions 71
Intrauterine Synechiae 52
Adhesions of Uterus 71
Uterine Synechiae 52

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

ICD10 via Orphanet 33 N85.6
UMLS via Orphanet 72 C0156372 C0241593 C1704274
Orphanet 58 ORPHA137686
UMLS 71 C0156372 C0241593 C1704274

Summaries for Asherman's Syndrome

MalaCards based summary : Asherman's Syndrome, also known as asherman syndrome, is related to amenorrhea and infertility. An important gene associated with Asherman's Syndrome is NFKB1 (Nuclear Factor Kappa B Subunit 1). The drugs Dimenhydrinate and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include uterus, bone and placenta, and related phenotypes are secondary amenorrhea and abnormality of the menstrual cycle

Related Diseases for Asherman's Syndrome

Diseases related to Asherman's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 amenorrhea 10.7
2 infertility 10.7
3 placenta accreta 10.6
4 adhesions of uterus 10.4
5 endometritis 10.3
6 endometriosis 10.3
7 cervical incompetence 10.3
8 preterm premature rupture of the membranes 10.3
9 ectopic pregnancy 10.2
10 placenta praevia 10.2
11 placenta disease 10.2
12 rapidly involuting congenital hemangioma 10.2
13 myoma 10.2
14 schistosoma mansoni infection, susceptibility/ 10.1
15 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
16 pre-eclampsia 10.1
17 schistosomiasis 10.1
18 hemometra 10.1
19 uterine inversion 10.1
20 adenomyosis 10.0
21 leiomyoma 10.0
22 myofibroma 10.0
23 severe combined immunodeficiency 10.0
24 placental abruption 10.0
25 septate uterus 10.0
26 uterine anomalies 10.0
27 scoliosis 10.0
28 thrombosis 10.0
29 hypogonadotropic hypogonadism 10.0
30 hypogonadism 10.0
31 thrombophilia 10.0
32 aneurysm 10.0
33 bicornuate uterus 10.0
34 constricting bands, congenital 10.0
35 endometrial cancer 10.0
36 endometrial adenocarcinoma 10.0

Comorbidity relations with Asherman's Syndrome via Phenotypic Disease Network (PDN):


Myofibroma

Graphical network of the top 20 diseases related to Asherman's Syndrome:



Diseases related to Asherman's Syndrome

Symptoms & Phenotypes for Asherman's Syndrome

Human phenotypes related to Asherman's Syndrome:

58 (show all 11)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 secondary amenorrhea 58 Occasional (29-5%)
2 abnormality of the menstrual cycle 58 Frequent (79-30%)
3 infertility 58 Occasional (29-5%)
4 dysmenorrhea 58 Occasional (29-5%)
5 spontaneous abortion 58 Occasional (29-5%)
6 decreased fertility in females 58 Frequent (79-30%)
7 metrorrhagia 58 Occasional (29-5%)
8 episodic abdominal pain 58 Occasional (29-5%)
9 oligomenorrhea 58 Frequent (79-30%)
10 abnormality of the placenta 58 Very rare (<4-1%)
11 chronic infection 58 Very rare (<4-1%)

Drugs & Therapeutics for Asherman's Syndrome

Drugs for Asherman's Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dimenhydrinate Approved Phase 4 523-87-5 441281
2
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
3
Polyestradiol phosphate Approved Phase 4 28014-46-2
4 Carboxymethylcellulose Sodium Phase 4
5 Progestins Phase 4
6 Estradiol 17 beta-cypionate Phase 4
7 Hormone Antagonists Phase 4
8 Estradiol 3-benzoate Phase 4
9 Contraceptive Agents Phase 4
10 Estrogens Phase 4
11 Hormones Phase 4
12
Misoprostol Approved Phase 3 59122-46-2 5282381
13
Mifepristone Approved, Investigational Phase 3 84371-65-3 55245
14
Tacrolimus Approved, Investigational Phase 3 104987-11-3 445643 439492 6473866
15 Contraceptives, Oral Phase 3
16 Contraceptives, Postcoital Phase 3
17 Immunologic Factors Phase 3
18 Immunosuppressive Agents Phase 3
19 Calcineurin Inhibitors Phase 3
20
Sargramostim Approved, Investigational Phase 1, Phase 2 83869-56-1, 123774-72-1
21
Lenograstim Approved, Investigational Phase 1, Phase 2 135968-09-1
22 Anti-Bacterial Agents Phase 2
23 Antibiotics, Antitubercular Phase 2
24 Adjuvants, Immunologic Phase 1, Phase 2
25 Pharmaceutical Solutions Phase 1
26
Ethanol Approved Early Phase 1 64-17-5 702
27
Aspirin Approved, Vet_approved 50-78-2 2244
28
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
29
Progesterone Approved, Vet_approved 57-83-0 5994
30
Zaleplon Approved, Illicit, Investigational 151319-34-5 5719
31
Iodine Approved, Investigational 7553-56-2 807
32
Povidone Approved 9003-39-8
33
carbamide peroxide Approved 124-43-6
34
Povidone-iodine Approved 25655-41-8
35
Lidocaine Approved, Vet_approved 137-58-6 3676
36
Medroxyprogesterone acetate Approved, Investigational 71-58-9
37
Prednisone Approved, Vet_approved 53-03-2 5865
38
Mycophenolic acid Approved 24280-93-1 446541
39
Azathioprine Approved 446-86-6 2265
40 Molgramostim Investigational 99283-10-0
41
Imidacloprid Vet_approved 105827-78-9 86418
42 Viscosupplements
43 Protective Agents
44 Calamus
45 cadexomer iodine
46 Anesthetics
47
Medroxyprogesterone 520-85-4 10631
48 Thymoglobulin

Interventional clinical trials:

(show top 50) (show all 70)
# Name Status NCT ID Phase Drugs
1 The Role of Seprafilm Bioresorbable Slurry in the Prevention of Intrauterine Synechiae in Patients Undergoing Hysteroscopic Myomectomy Unknown status NCT01632202 Phase 4
2 Effectiveness of Self-cross-linked Hyaluronic Acid Gel in the Prevention of Intrauterine Adhesions After Second Trimester Abortion Unknown status NCT02868437 Phase 4
3 Clinical Study of the Treatment of Infertility Caused by Severe Intrauterine Adhesions by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells Unknown status NCT02204358 Phase 4
4 New Therapeutic Approaches to Treat Asherman's Syndrome and Endometrial Atrophy Based in BM Stem Cells Autologous Transplantation Completed NCT02144987 Phase 4
5 The Effect of Estrogen in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis Enrolling by invitation NCT03620929 Phase 4 Estradiol Valerate
6 Cervical Preparation for Surgical Abortion at 12-14 Weeks: a Prospective, Randomized, Evaluator-blinded, Multicenter, Controlled Comparison Between Mifepristone, Misoprostol and Their Combination Unknown status NCT01795599 Phase 3 Mifegyne ®;Gymiso®
7 Uterus Transplantation From Live Donors and From Deceased Donors - Clinical Study Recruiting NCT03277430 Phase 3 Tacrolimus
8 Non-stick Gel Applicated After Scraping Surgery for Natural Miscarriage and Uterine Synechiae Prevention Active, not recruiting NCT02248376 Phase 3 Gel
9 A Multi-center, Randomized, Single-blind, Controlled Clinical Trial of Treatment of Severe Asherman Syndrome by Collagen Scaffold Loaded With Autologous Bone Marrow Mononuclear Cells Unknown status NCT02680366 Phase 2
10 Platelet-Rich Plasma in the Management of Asherman Syndrome Completed NCT04308811 Phase 2
11 A Prospective, Randomized, Controlled Trial Comparing 2 Different Doses of Estrogen Therapy After Hysteroscopic Adhesiolysis as an Adjuvant to Prevent Recurrence of Intrauterine Adhesions Completed NCT02726971 Phase 1, Phase 2 Femoston
12 Platelet-rich Plasma (PRP) for Endometrial Regeneration and Repair: a Prospective Randomised Pilot Study Completed NCT02825849 Phase 2
13 Open Randomized Trial of Clinical Efficiency and Safety of Cell Product of Autologous Bone Marrow-derived Mesenchymal Stem Cells for Reparative Treatment of Destructively Changed Endometrium in Patients With Repeated IVF Failures Completed NCT03166189 Phase 2
14 Intrauterine Infusion of Autologous Platelet-Rich Plasma (PRP) in Women With Thin Endometrium Undergoing Embryo-transfer. Recruiting NCT03067623 Phase 2 PRP
15 G-CSF and Endometrial Growth, Embryo Implantation and Pregnancy Following FET or Donor ET Terminated NCT01202643 Phase 1, Phase 2 G-CSF;Saline
16 Phase I Study of Role of Stem Cells in Improving Implantation Rates in ICSI Patients Unknown status NCT01649752 Phase 1
17 Cesarean Myomectomy : Safety and Risk of Intrauterine Synechiae Completed NCT03095014 Phase 1
18 Safety and Therapeutic Effect of Human Amniotic Epithelial Cells in Severe Refractory Asherman's Syndrome Not yet recruiting NCT03223454 Phase 1
19 Clinical Safety Study of Human Embryonic Stem Cell Derived Mesenchymal Cells in the Treatment of Moderate and Severe Intrauterine Adhesions Not yet recruiting NCT04232592 Phase 1
20 Randomized, Controlled Trial to Assess the Efficacy of Disposable Balloon Uterine Stent Combined With Estrogen or Dried Biological Amnion Graft for the Therapy of Uterine Adhesion Unknown status NCT03346317 estradiol valerate tablets+dydrogesterone tablets
21 Randomized, Controlled Trial to Assess the Efficacy of Estrogen Therapy Combined With Disposable Balloon Uterine Stent and Dried Biological Amnion Graft in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis Unknown status NCT03351205 estradiol valerate tablets+dydrogesterone tablets
22 Randomized, Controlled Trial to Assess the Efficacy of Disposable Balloon Uterine Stent and Foley Catheter in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis Unknown status NCT03330873
23 Randomized, Controlled Trial to Assess the Efficacy of Disposable Balloon Uterine Stent Combined With Estrogen or Dried Biological Amnion Graft in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis Unknown status NCT03329898 estradiol valerate tablets;dydrogesterone Tablets
24 Amnion Graft for Preventing Intrauterine Adhesions Following Hysteroscopic Surgery Unknown status NCT02132104 Femoston
25 The Efficacy of G-CSF Against Adhesion Reformation After Hysteroscopic Adhesiolysis Unknown status NCT02855632 G-CSF;Normal saline;hormone therapy
26 Use Of Hyaluronic Acid Gel To Prevent Intrauterine Adhesions In Hysteroscopic Surgery Unknown status NCT01464528 Early Phase 1 Hyaluronan
27 The Efficacy and Safety of the Dried Biological Amnion Graft Following Hysteroscopic Lysis for the Prevention of Postoperative Adhesions in Patients With Intrauterine Adhesions Unknown status NCT02496052 estradiol valerate tablets+dydrogesterone Tablets
28 Prevention of Intrauterine Adhesions After Hysteroscopic Metroplasty With Autocross-linked Hyaluronic Acid Gel Unknown status NCT02404454
29 Randomized, Controlled Trial Comparing Immediate and Delayed Intrauterine Balloon Therapy in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis Unknown status NCT03171454
30 Efficiency of INTERCOAT (Oxiplex/AP Gel) in Preventing Intrauterine Adhesion Formation in Hysteroscopic Surgery - a Prospective Double Blind Randomized Study Unknown status NCT01637974 INTERCOAT administration
31 Effect of Pelvic Floor Muscle Electrophysiologic Therapy on Enhanced Recovery After Gynecologic Surgery Unknown status NCT03524807
32 The Efficacy of Intrauterine Balloon Dilatation Therapy in the Prevention of Adhesion Formation After Hysteroscopicremovalof Multiple Fibroids Unknown status NCT03169478
33 Description of the Uterine Cavity in Patients With Recurrent Miscarriages Unknown status NCT02746588
34 MONOBISY: Randomized Controlled Trial Comparing Intra Uterine Synechiae Occurence Using Bipolar Energy Compared With Monopolar Energy in Myoma Resection on Women Having Menorraghia and/or Infertility Unknown status NCT02661087
35 Vaginal Antimicrobacterial Preparation Before Cesarean Secation for Endometritis Prevention Unknown status NCT03093194
36 The Value of Diagnostic Hysterolaparoscopy in Infertile Patients With Normal Hysterosalpingography Unknown status NCT03106012
37 Intercoat (Oxiplex/AP Gel) for Preventing Intrauterine Adhesions Following Operative Hysteroscopy for Suspected Retained Products of Conception - a Prospective Randomized Pilot Study Completed NCT01377779 Oxiplex/AP gel;Normal Saline
38 Reproductive Outcome Affected by Two Adjunctive Treatments in Patients With Infertility Due to Severe Intrauterine Adhesions. Completed NCT02708277
39 Prevalence of Chronic Endometritis in Severe Intrauterine Adhesions and Role of Chronic Endometritis in Postoperative Recurrence of Severe Intrauterine Completed NCT02744807
40 The Value of Using Platelet Rich Plasma After Hysteroscopic Lysis of Severe Intrauterine Adhesions (A Randomized Controlled Trial) Completed NCT03541746
41 Impact of Mindfulness Based Stress Reduction on Anxiety, Depression and Quality of Life in Women With Intrauterine Adhesion:a Randomized Controlled Trial. Completed NCT02746679
42 A Randomized Clinical Trial to Assess the Efficacy of Intrauterine Balloon Compared to Intrauterine Contraceptive Device Plus Foley Catheter in the Therapy for Uterine Adhesion After Hysteroscopic Adhesiolysis Completed NCT02867202
43 Prevention of Postoperative Adhesion Reformation by Intrauterine Balloon Therapy: a Randomized Controlled Trial Completed NCT03131596
44 Autocrosslinked Hyaluronic Acid Gel in Prevention of Intrauterine Adhesions After Bipolar Radiofrequency Endometrial Ablation: a Randomised, Controlled and Double Blind Study Completed NCT01829451
45 Evaluation of Uterine Patency Following Sonography-guided Transcervical Ablation of Fibroids Completed NCT02844920
46 Clinical Study of the Treatment of Infertility Caused by Recurrent Intrauterine Adhesions by Collagen Scaffold Loaded With Umbilical Cord -Derived Mesenchymal Stem Cells (UC-MSCs) Completed NCT02313415
47 The Efficacy of A New Crosslinked Hyaluronan Gel in the Prevention of Postoperative Intrauterine Adhesion After Dilatation and Curettage in Women With Delayed Miscarriage: A Prospective, Randomized, Controlled Trial Completed NCT03353909
48 A Post-Market Clinical Follow-up Study to Investigate the Usability of the CollaGUARD Adhesion Barrier Following Hysteroscopic Adhesiolysis Completed NCT02348541 Early Phase 1
49 Prevention of Postsurgical Uterine Synechia With HyalobarrierR Gel Endo in Hysteroscopic Myomectomy : a Prospective Multicenter Study Completed NCT01412489
50 Magnetic Resonance Imaging Hysterosalpingography Versus Radiographic Hysterosalpingography in Female Infertility Completed NCT02108665

Search NIH Clinical Center for Asherman's Syndrome

Genetic Tests for Asherman's Syndrome

Anatomical Context for Asherman's Syndrome

MalaCards organs/tissues related to Asherman's Syndrome:

40
Uterus, Bone, Placenta, Bone Marrow, Cervix, Endothelial

Publications for Asherman's Syndrome

Articles related to Asherman's Syndrome:

(show top 50) (show all 313)
# Title Authors PMID Year
1
Evaluation and treatment of infertile women with Asherman syndrome: an updated review focusing on the role of hysteroscopy. 61
32444259 2020
2
Intrauterine infusion of platelet-rich plasma for severe Asherman syndrome: a cutting-edge approach. 61
32514742 2020
3
Uterine body placenta accreta spectrum: A detailed literature review. 61
32452401 2020
4
Genital TB screening at an academic fertility center in the US. 61
32497612 2020
5
Secondary Prevention of Intrauterine Adhesions Following Hysteroscopic Surgery in Women With Asherman Syndrome: Is Something Better Than Nothing? 61
31815774 2020
6
A prospective randomized controlled trial comparing two different treatments of intrauterine adhesions. 61
32376313 2020
7
Comparison of the regenerative effects of bone marrow/adipose-derived stem cells in the Asherman model following local or systemic administration. 61
32535814 2020
8
Understanding the regulatory mechanisms of endometrial cells on activities of endometrial mesenchymal stem-like cells during menstruation. 61
32552749 2020
9
Adipose derived mesenchymal stem cell treatment in experimental asherman syndrome induced rats. 61
32444974 2020
10
An update on stem cell therapy for Asherman syndrome. 61
32445154 2020
11
Endometrial autotransplantation in rabbits: Potential for fertility restoration in severe Asherman's syndrome. 61
32171148 2020
12
Asherman syndrome: Audit of a single-operator cohort of 423 cases. 61
32458458 2020
13
Asherman syndrome in adenomyosis treated with uterine artery embolization: incidence predictive factors. 61
32020527 2020
14
Perivascular Stem Cell-Derived Cyclophilin A Improves Uterine Environment with Asherman's Syndrome via HIF1α-Dependent Angiogenesis. 61
32534604 2020
15
Meta-analysis on the use of hyaluronic acid gel to prevent intrauterine adhesion after intrauterine operations. 61
32256748 2020
16
Stem cell paracrine actions in tissue regeneration and potential therapeutic effect in human endometrium: a retrospective study. 61
31876085 2020
17
Should we consider alternative therapies to operative hysteroscopy for the treatment of Asherman syndrome? 61
32111470 2020
18
Operative hysteroscopy should be repeated as many times as necessary for the treatment of refractory Asherman syndrome versus is there any alternative therapy worth considering? 61
32089254 2020
19
Effect of Autologous Adipose-Derived Stromal Vascular Fraction Transplantation on Endometrial Regeneration in Patients of Asherman's Syndrome: a Pilot Study. 61
32046396 2020
20
Platelet-rich plasma in the management of Asherman's syndrome: An RCT. 61
32259005 2020
21
Establishment of an animal model of intrauterine adhesions after surgical abortion and curettage in pregnant rats. 61
32175350 2020
22
Meta-analysis of the use of hyaluronic acid gel to prevent intrauterine adhesions after miscarriage. 61
31731019 2020
23
Asherman syndrome and insufficient endometrial thickness: A hypothesis of integrated approach to restore the endometrium. 61
31887722 2020
24
Intrauterine Infusion of Human Platelet-Rich Plasma Improves Endometrial Regeneration and Pregnancy Outcomes in a Murine Model of Asherman's Syndrome. 61
32116803 2020
25
Advances in the Application of Biomimetic Endometrium Interfaces for Uterine Bioengineering in Female Infertility. 61
32181248 2020
26
Endometrial stromal cells exhibit a distinct phenotypic and immunomodulatory profile. 61
31907034 2020
27
Effects of uterus derived mesenchymal stem cells and their exosomes on asherman's syndrome. 61
31776004 2020
28
Autologous Bone Marrow-Derived Stem Cell Therapy for Asherman's Syndrome and Endometrial Atrophy: A 5-Year Follow-up Study. 61
32577066 2020
29
CSF1-associated decrease in endometrial macrophages may contribute to Asherman's syndrome. 61
31536655 2020
30
Meta-analysis on the use of hyaluronic acid gel to prevent recurrence of intrauterine adhesion after hysteroscopic adhesiolysis. 61
31759520 2019
31
Effectiveness, complications and reproductive outcome of selective chemoembolization with methotrexate followed by suction curettage for caesarean scar pregnancy - A prospective observational study. 61
31437622 2019
32
Vascular endothelial growth factor 165 inhibits pro-fibrotic differentiation of stromal cells via the DLL4/Notch4/smad7 pathway. 61
31515487 2019
33
A cohort study comparing 4 mg and 10 mg daily doses of postoperative oestradiol therapy to prevent adhesion reformation after hysteroscopic adhesiolysis. 61
29504823 2019
34
Human amniotic epithelial cells improve fertility in an intrauterine adhesion mouse model. 61
31412924 2019
35
Reproductive outcomes after surgical treatment of asherman syndrome: A systematic review. 61
30713131 2019
36
Assisted reproductive technology strategies in uterus transplantation. 61
31277762 2019
37
A cohort study comparing the severity and outcome of intrauterine adhesiolysis for Asherman syndrome after first- or second-trimester termination of pregnancy. 61
31082744 2019
38
Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell-Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome. 61
31148407 2019
39
One-Year Follow-Up of Women with Severe Acute Maternal Morbidity (SAMM): A Cohort Study. 61
31178635 2019
40
Mechanisms of endometrial fibrosis and the potential application of stem cell therapy. 61
31421695 2019
41
Cell and biomaterial-based approaches to uterus regeneration. 61
31198582 2019
42
Cellular therapies for the endometrium: An update. 61
30815850 2019
43
Single cell-derived clonally expanded mesenchymal progenitor cells from somatic cell nuclear transfer-derived pluripotent stem cells ameliorate the endometrial function in the uterus of a murine model with Asherman's syndrome. 61
30896075 2019
44
A Novel Ultrasound-Guided Technique for Hysteroscopic Adhesiolysis in High-Risk Patients. 61
30208242 2019
45
Bioengineering strategies of the uterus towards improving current investigative models and female reproductive health. 61
31695861 2019
46
Bone Marrow Mesenchymal Stem Cells (BMSCs) Restore Functional Endometrium in the Rat Model for Severe Asherman Syndrome. 61
30458678 2019
47
The efficacy of Ankaferd Blood Stopper® in an experimental Asherman syndrome model created in rats. 61
31019834 2019
48
Asherman's syndrome: current perspectives on diagnosis and management. 61
30936754 2019
49
Endometrial Regeneration in Asherman's Syndrome: Clinical and Translational evidence of Stem Cell Therapies. 61
30760192 2019
50
Silicone Plate for the Prevention of Postoperative Adhesions in Patients with Asherman Syndrome. 61
31871802 2019

Variations for Asherman's Syndrome

Expression for Asherman's Syndrome

Search GEO for disease gene expression data for Asherman's Syndrome.

Pathways for Asherman's Syndrome

GO Terms for Asherman's Syndrome

Sources for Asherman's Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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