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MCID: ASH001
MIFTS: 29

Asherman's Syndrome

Categories: Rare diseases, Reproductive diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Asherman's Syndrome

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MalaCards integrated aliases for Asherman's Syndrome:

Name: Asherman's Syndrome 53
Asherman Syndrome 53 59 73
Intrauterine Adhesions 59 73
Intrauterine Synechiae 53 59
Adhesions of Uterus 73
Uterine Synechiae 53

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 34
Orphanet: 59  
Rare gynaecological and obstetric diseases


External Ids:

Orphanet 59 ORPHA137686
UMLS via Orphanet 74 C0241593 C0156372 C1704274
ICD10 via Orphanet 34 N85.6
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Summaries for Asherman's Syndrome

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MalaCards based summary : Asherman's Syndrome, also known as asherman syndrome, is related to adhesions of uterus and scoliosis. An important gene associated with Asherman's Syndrome is NFKB1 (Nuclear Factor Kappa B Subunit 1). The drugs Hyaluronic acid and Dimenhydrinate have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and bone.

Wikipedia : 76 \"Asherman\'s Syndrome\",which is also referred to as intrauterine adhesions (IUA) or intrauterine... more...

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Related Diseases for Asherman's Syndrome

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Diseases related to Asherman's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 adhesions of uterus 11.6
2 scoliosis 9.9
3 placenta accreta 9.9
4 myoma 9.8
5 endometritis 9.6
6 amenorrhea 9.6
7 type i 9.6

Comorbidity relations with Asherman's Syndrome via Phenotypic Disease Network (PDN):


Endometriosis of Uterus Myofibroma

Graphical network of the top 20 diseases related to Asherman's Syndrome:



Diseases related to Asherman's Syndrome
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Symptoms & Phenotypes for Asherman's Syndrome

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Drugs & Therapeutics for Asherman's Syndrome

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Drugs for Asherman's Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3 9004-61-9 53477741
2
Dimenhydrinate Approved Phase 4 523-87-5 441281
3 Adjuvants, Immunologic Phase 4,Phase 1,Phase 2,Not Applicable
4 Viscosupplements Phase 4
5 Pharmaceutical Solutions Phase 4
6 Protective Agents Phase 4
7 Carboxymethylcellulose Sodium Phase 4
8
Mifepristone Approved, Investigational Phase 3 84371-65-3 55245
9
Misoprostol Approved Phase 3 59122-46-2 5282381
10 Gastrointestinal Agents Phase 3
11 Contraceptive Agents Phase 3,Not Applicable
12 Contraceptives, Oral Phase 3
13 Contraceptives, Postcoital Phase 3
14 Hormone Antagonists Phase 3,Phase 1,Phase 2,Not Applicable
15 Hormones Phase 3,Phase 1,Phase 2,Not Applicable
16 Oxytocics Phase 3
17 Antacids Phase 3
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1,Phase 2,Not Applicable
19 Luteolytic Agents Phase 3
20 Anti-Ulcer Agents Phase 3
21 Estradiol valerate Approved, Investigational, Vet_approved Phase 1, Phase 2,Not Applicable 979-32-8
22
Estradiol Approved, Investigational, Vet_approved Phase 1, Phase 2,Not Applicable 50-28-2 5757
23
Polyestradiol phosphate Approved Phase 1, Phase 2,Not Applicable 28014-46-2
24
Lenograstim Approved, Investigational Phase 1, Phase 2,Not Applicable 135968-09-1
25 Progestins Phase 1, Phase 2,Not Applicable
26 Estradiol 17 beta-cypionate Phase 1, Phase 2,Not Applicable
27 Estradiol 3-benzoate Phase 1, Phase 2,Not Applicable
28 Estrogens Phase 1, Phase 2,Phase 2,Not Applicable
29 Anesthetics Phase 2,Phase 1
30 Anti-Bacterial Agents Phase 2,Phase 1
31 Antibiotics, Antitubercular Phase 2,Phase 1
32
Copper Approved, Investigational Not Applicable 7440-50-8 27099
33
Progesterone Approved, Vet_approved Not Applicable 57-83-0 5994
34
Medroxyprogesterone acetate Approved, Investigational Not Applicable 71-58-9
35
Medroxyprogesterone Not Applicable 520-85-4 10631
36 Calamus Nutraceutical Not Applicable

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy Unknown status NCT01632202 Phase 4
2 Bone Marrow Stem Cell Treatment for Asherman's Syndrome and Endometrial Atrophy Completed NCT02144987 Phase 4
3 Cervical Preparation for Surgical Abortion at 12-14 Weeks: a Prospective, Randomized, Evaluator-blinded, Multicenter, Controlled Comparison Between Mifepristone, Misoprostol and Their Combination Unknown status NCT01795599 Phase 3 Mifegyne ®;Gymiso®
4 Hyaluronic Acid and Uterine Synechiae Active, not recruiting NCT02248376 Phase 3 Gel
5 Comparison of Different Doses of Oestrogen Therapy for Preventing Intrauterine Adhesion Completed NCT02726971 Phase 1, Phase 2 Femoston
6 Treatment of Severe Asherman Syndrome by Collagen Scaffold Loaded With Autologous Bone Marrow Mononuclear Cells Recruiting NCT02680366 Phase 2
7 Platelet-rich Plasma (PRP) for Endometrial Regeneration and Repair Recruiting NCT02825849 Phase 2
8 Autologous Bone Marrow-derived Mesenchymal Stem Cells for Atrophic Endometrium in Patients With Repeated IVF Failures Recruiting NCT03166189 Phase 2
9 Effect of Colony Stimulating Factor on Poor Endometrial Development During IVF Terminated NCT01202643 Phase 1, Phase 2 G-CSF;Saline
10 Role of Stem Cells in Improving Implantation Rates in ICSI Patients Unknown status NCT01649752 Phase 1
11 Myomectomy During Cesarean Section Completed NCT03095014 Phase 1
12 Human Amniotic Epithelial Cells for Asherman's Syndrome Not yet recruiting NCT03223454 Phase 1
13 Efficiency of INTERCOAT (Oxiplex/AP Gel) in Preventing Intrauterine Adhesion Formation in Hysteroscopic Surgery Unknown status NCT01637974 Not Applicable INTERCOAT administration
14 Description of the Uterine Cavity in Patients With Recurrent Miscarriages Unknown status NCT02746588
15 Efficiency of Amnion Graft to Prevent Intrauterine Adhesions After Hysteroscopic Surgery Unknown status NCT02132104 Not Applicable Femoston
16 Efficiency of Intercoat (Oxiplex/AP Gel)in Decreasing Intrauterine Adhesions Completed NCT01377779 Not Applicable Oxiplex/AP gel;Normal Saline
17 Impact of Mindfulness Based Stress Reduction on Anxiety, Depression and QOL in Women With Intrauterine Adhesion. Completed NCT02746679 Not Applicable
18 Intrauterine Adhesion Rate After Hysteroscopic Myomectomy and Application of HYALOBARRIER Gel Completed NCT01412489 Not Applicable
19 Reproductive Outcome Affected by Two Adjunctive Treatments in Patients With Severe Intrauterine Adhesions Completed NCT02708277 Not Applicable
20 The Efficacy and Safety of Disposable Balloon Uterine Stent in Patients With Asherman Syndrome Recruiting NCT03330873 Not Applicable
21 Comparing the Efficacy of Intrauterine Balloon and Intrauterine Contraceptive Device for the Therapy of Uterine Adhesion Recruiting NCT02867202 Not Applicable
22 Use of PRP in Endometrial Reconstruction Recruiting NCT03249415
23 Comparing Intra Uterine Synechiae Occurence Using Bipolar Energy Compared With Monopolar Energy in Myoma Resection on Women Having Menorraghia and/or Infertility Recruiting NCT02661087 Not Applicable
24 Intrauterine Balloon Therapy to Prevent the Recurrence of Intrauterine Adhesions Recruiting NCT03131596 Not Applicable
25 Comparing the Efficacy of Two Methods for the Therapy of Uterine Adhesion Recruiting NCT03329898 Not Applicable estradiol valerate tablets;dydrogesterone Tablets
26 Comparing the Efficacy of Two Methods in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis Recruiting NCT03346317 Not Applicable estradiol valerate tablets+dydrogesterone tablets
27 The Efficacy of Estrogen Therapy Against Adhesion Reformation After Hysteroscopic Adhesiolysis Recruiting NCT03351205 Not Applicable estradiol valerate tablets+dydrogesterone tablets
28 The Efficacy of G-CSF Against Adhesion Reformation After Hysteroscopic Adhesiolysis Recruiting NCT02855632 Not Applicable G-CSF;Normal saline;hormone therapy
29 Human Amniotic Epithelial Cell in Treatment of Refractory Severe Intrauterine Adhesion Not yet recruiting NCT03381807 Early Phase 1
30 Development of a Bioabsorbable Medical Device for the Prevention of Postoperative Intra-uterine Adhesions. Withdrawn NCT02328742

Search NIH Clinical Center for Asherman's Syndrome

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Genetic Tests for Asherman's Syndrome

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Anatomical Context for Asherman's Syndrome

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MalaCards organs/tissues related to Asherman's Syndrome:

41
Uterus, Cervix, Bone, Bone Marrow, Placenta
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Publications for Asherman's Syndrome

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Articles related to Asherman's Syndrome:

(show top 50) (show all 91)
# Title Authors Year
1
Placenta Accreta following Hysteroscopic Lysis of Adhesions Caused by Asherman's Syndrome: A Case Report and Literature Review. ( 29955406 )
2018
2
Hysteroscopic Management of Asherman's Syndrome. ( 29024798 )
2018
3
The effect of endometrial thickness on pregnancy outcome in patients with Asherman's syndrome post-hysteroscopic adhesiolysis. ( 29483785 )
2018
4
Elevated NF-I_B signaling in Asherman syndrome patients and animal models. ( 28148903 )
2017
5
CXCL12 Promotes Stem Cell Recruitment and Uterine Repair after Injury in Asherman's Syndrome. ( 28345002 )
2017
6
A comprehensive review of Asherman's syndrome: causes, symptoms and treatment options. ( 28582327 )
2017
7
Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating I9Np63 expression in Asherman's syndrome. ( 27921235 )
2016
8
Induction of Asherman's Syndrome in Rabbit. ( 26962478 )
2016
9
Autologous menstrual blood-derived stromal cells transplantation for severe Asherman's syndrome. ( 27664218 )
2016
10
Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman's syndrome and endometrial atrophy: a pilot cohort study. ( 27005892 )
2016
11
Reproductive Outcome of Patients With Asherman's Syndrome After Hysteroscopic Adhesiolysis. ( 27678984 )
2015
12
Reproductive Outcome of Patients with Asherman's Syndrome: A SAIMS Experience. ( 27110522 )
2015
13
Management of false passage created during hysteroscopic adhesiolysis for Asherman's syndrome. ( 26207696 )
2015
14
Treatment of Asherman's syndrome in an outpatient hysteroscopy setting. ( 25497164 )
2015
15
Placenta accreta: adherent placenta due to Asherman syndrome. ( 25838908 )
2015
16
A 10-year Review of the Clinical Presentation and Treatment Outcome of Asherman's Syndrome at a Center with Limited Resources. ( 27057384 )
2015
17
Treatment of Asherman's Syndrome in an Outpatient Hysteroscopy Setting. ( 27678648 )
2015
18
A matched cohort study comparing the outcome of intrauterine adhesiolysis for Asherman's syndrome after uterine artery embolization or surgical trauma. ( 24842805 )
2014
19
Bone Marrow-Derived Stem Cell (BMDSC) transplantation improves fertility in a murine model of Asherman's syndrome. ( 24819371 )
2014
20
Curettage and Asherman's syndrome-lessons to (re-) learn? ( 25574677 )
2014
21
Autologous stem cell transplantation in refractory Asherman's syndrome: A novel cell based therapy. ( 25191021 )
2014
22
A rare case of Asherman's syndrome after open myomectomy: sonographic investigations and possible underlying mechanisms. ( 24557451 )
2014
23
Use of a hysteroscopic morcellator to resect miscarriage in a woman with recurrent Asherman's syndrome. ( 24865632 )
2014
24
Regenerating endometrium from stem/progenitor cells: is it abnormal in endometriosis, Asherman's syndrome and infertility? ( 23562953 )
2013
25
The Diagnosis and Management of Asherman's Syndrome Developed after Cesarean Section and Reproductive Outcome. ( 23840987 )
2013
26
Asherman's syndrome. ( 23600077 )
2013
27
Secondary amenorrhea in severe Asherman's syndrome: Step by step fertility retrieval by Bettocchi's hysteroscope: Some considerations. ( 24024657 )
2013
28
Role of 3D sonohysterography in the investigation of uterine synechiae/asherman's syndrome: Pictorial assay. ( 24314038 )
2013
29
Severe Asherman's syndrome complicated with placenta increta conceived by intracytoplasmic sperm injection following hysteroscopic surgery. ( 23444767 )
2012
30
Changes in endometrial receptivity in women with Asherman's syndrome undergoing hysteroscopic adhesiolysis. ( 22535194 )
2012
31
Comprehensive management of severe Asherman syndrome and amenorrhea. ( 22100167 )
2012
32
Management of Asherman's syndrome. ( 21549641 )
2011
33
Endometrial regeneration using autologous adult stem cells followed by conception by in vitro fertilization in a patient of severe Asherman's syndrome. ( 21772740 )
2011
34
Generating receptive endometrium in Asherman's syndrome. ( 21772741 )
2011
35
Asherman's syndrome. ( 21437822 )
2011
36
Separated from birth: an initial examination suggested Asherman's syndrome. ( 20594543 )
2010
37
Reproductive outcome following hysteroscopic adhesiolysis in patients with infertility due to Asherman's syndrome. ( 19455349 )
2010
38
Postoperative adhesiolysis therapy for intrauterine adhesions (Asherman's syndrome). ( 18571166 )
2008
39
Genital tuberculosis: an important cause of Asherman's syndrome in India. ( 17653564 )
2008
40
Placenta accreta: an association with fibroids and Asherman syndrome. ( 18946102 )
2008
41
Factors affecting reproductive outcome of hysteroscopic adhesiolysis for Asherman's syndrome. ( 17681324 )
2008
42
Fluoroscopically guided synechiolysis for patients with Asherman's syndrome: menstrual and fertility outcomes. ( 17109860 )
2007
43
Value of 3D ultrasound in the management of suspected Asherman's syndrome. ( 18161399 )
2007
44
Severe Asherman's syndrome. ( 17915059 )
2007
45
Fertility after treatment of Asherman's syndrome stage 3 and 4. ( 16962521 )
2006
46
Successful use of vaginal sildenafil citrate in two infertility patients with Asherman's syndrome. ( 16724891 )
2006
47
Intrapartum spontaneous uterine rupture following uncomplicated resectoscopic treatment of Asherman's syndrome. ( 15880989 )
2005
48
Live delivery rates in subfertile women with Asherman's syndrome after hysteroscopic adhesiolysis using the resectoscope or the Versapoint system. ( 15169591 )
2004
49
SprayGel following surgery for Asherman's syndrome may improve pregnancy outcome. ( 16147625 )
2004
50
Severe early-onset intrauterine growth restriction (IUGR) in a woman with Asherman's syndrome. ( 15203638 )
2004
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Variations for Asherman's Syndrome

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Expression for Asherman's Syndrome

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Search GEO for disease gene expression data for Asherman's Syndrome.
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Pathways for Asherman's Syndrome

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GO Terms for Asherman's Syndrome

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Sources for Asherman's Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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