MCID: ASH001
MIFTS: 30

Asherman's Syndrome

Categories: Rare diseases, Reproductive diseases

Aliases & Classifications for Asherman's Syndrome

MalaCards integrated aliases for Asherman's Syndrome:

Name: Asherman's Syndrome 53
Asherman Syndrome 53 59 73
Intrauterine Adhesions 59 73
Intrauterine Synechiae 53 59
Adhesions of Uterus 73
Uterine Synechiae 53

Classifications:



External Ids:

Orphanet 59 ORPHA137686
UMLS via Orphanet 74 C0241593 C0156372 C1704274
ICD10 via Orphanet 34 N85.6

Summaries for Asherman's Syndrome

MalaCards based summary : Asherman's Syndrome, also known as asherman syndrome, is related to adhesions of uterus and placenta accreta. An important gene associated with Asherman's Syndrome is NFKB1 (Nuclear Factor Kappa B Subunit 1). The drugs Hyaluronic acid and Dimenhydrinate have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and bone.

Wikipedia : 76 Asherman''s syndrome (AS), which is also referred to as intrauterine adhesions (IUA) or intrauterine... more...

Related Diseases for Asherman's Syndrome

Diseases related to Asherman's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 adhesions of uterus 11.8
2 placenta accreta 10.2
3 scoliosis 10.0
4 placenta disease 10.0
5 endometrial cancer 10.0
6 schistosomiasis 10.0
7 endometritis 9.9
8 myoma 9.9
9 amenorrhea 9.7
10 infertility 9.7

Comorbidity relations with Asherman's Syndrome via Phenotypic Disease Network (PDN):


Myofibroma

Graphical network of the top 20 diseases related to Asherman's Syndrome:



Diseases related to Asherman's Syndrome

Symptoms & Phenotypes for Asherman's Syndrome

Drugs & Therapeutics for Asherman's Syndrome

Drugs for Asherman's Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3 9004-61-9 53477741
2
Dimenhydrinate Approved Phase 4 523-87-5 441281
3
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 50-28-2 5757
4 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 979-32-8
5
Polyestradiol phosphate Approved Phase 4,Phase 1,Phase 2,Not Applicable 28014-46-2
6 Carboxymethylcellulose Sodium Phase 4
7 Immunologic Factors Phase 4,Phase 1,Phase 2,Not Applicable
8 Adjuvants, Immunologic Phase 4,Phase 1,Phase 2,Not Applicable
9 Pharmaceutical Solutions Phase 4
10 Protective Agents Phase 4
11 Viscosupplements Phase 4
12 Hormones Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
14 Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
15 Contraceptive Agents Phase 4,Phase 3,Not Applicable
16 Estradiol 3-benzoate Phase 4,Phase 1,Phase 2,Not Applicable
17 Estrogens Phase 4,Phase 1,Phase 2,Not Applicable
18 Estradiol 17 beta-cypionate Phase 4,Phase 1,Phase 2,Not Applicable
19 Progestins Phase 4,Phase 1,Phase 2,Not Applicable
20
Misoprostol Approved Phase 3 59122-46-2 5282381
21
Mifepristone Approved, Investigational Phase 3 84371-65-3 55245
22 Contraceptives, Oral Phase 3
23 Antacids Phase 3
24 Contraceptives, Postcoital Phase 3
25 Luteolytic Agents Phase 3
26 Gastrointestinal Agents Phase 3
27 Anti-Ulcer Agents Phase 3
28 Oxytocics Phase 3
29
Lenograstim Approved, Investigational Phase 1, Phase 2,Not Applicable 135968-09-1
30 Anesthetics Phase 2,Phase 1
31 Antibiotics, Antitubercular Phase 2,Phase 1
32 Anti-Bacterial Agents Phase 2,Phase 1
33
Copper Approved, Investigational Not Applicable 7440-50-8 27099
34
Medroxyprogesterone acetate Approved, Investigational Not Applicable 71-58-9
35
Progesterone Approved, Vet_approved Not Applicable 57-83-0 5994
36 Calamus Not Applicable
37
Medroxyprogesterone Not Applicable 520-85-4 10631

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy Unknown status NCT01632202 Phase 4
2 Bone Marrow Stem Cell Treatment for Asherman's Syndrome and Endometrial Atrophy Completed NCT02144987 Phase 4
3 Estrogen in the Prevention of Adhesion Reformation Enrolling by invitation NCT03620929 Phase 4 Estradiol Valerate
4 Cervical Preparation for Surgical Abortion at 12-14 Weeks: a Prospective, Randomized, Evaluator-blinded, Multicenter, Controlled Comparison Between Mifepristone, Misoprostol and Their Combination Unknown status NCT01795599 Phase 3 Mifegyne ®;Gymiso®
5 Hyaluronic Acid and Uterine Synechiae Active, not recruiting NCT02248376 Phase 3 Gel
6 Platelet-rich Plasma (PRP) for Endometrial Regeneration and Repair Unknown status NCT02825849 Phase 2
7 Comparison of Different Doses of Oestrogen Therapy for Preventing Intrauterine Adhesion Completed NCT02726971 Phase 1, Phase 2 Femoston
8 Treatment of Severe Asherman Syndrome by Collagen Scaffold Loaded With Autologous Bone Marrow Mononuclear Cells Recruiting NCT02680366 Phase 2
9 Autologous Bone Marrow-derived Mesenchymal Stem Cells for Atrophic Endometrium in Patients With Repeated IVF Failures Recruiting NCT03166189 Phase 2
10 Effect of Colony Stimulating Factor on Poor Endometrial Development During IVF Terminated NCT01202643 Phase 1, Phase 2 G-CSF;Saline
11 Role of Stem Cells in Improving Implantation Rates in ICSI Patients Unknown status NCT01649752 Phase 1
12 Myomectomy During Cesarean Section Completed NCT03095014 Phase 1
13 Human Amniotic Epithelial Cells for Asherman's Syndrome Not yet recruiting NCT03223454 Phase 1
14 Comparing the Efficacy of Intrauterine Balloon and Intrauterine Contraceptive Device for the Therapy of Uterine Adhesion Unknown status NCT02867202 Not Applicable
15 Efficiency of INTERCOAT (Oxiplex/AP Gel) in Preventing Intrauterine Adhesion Formation in Hysteroscopic Surgery Unknown status NCT01637974 Not Applicable INTERCOAT administration
16 Description of the Uterine Cavity in Patients With Recurrent Miscarriages Unknown status NCT02746588
17 Efficiency of Amnion Graft to Prevent Intrauterine Adhesions After Hysteroscopic Surgery Unknown status NCT02132104 Not Applicable Femoston
18 Efficiency of Intercoat (Oxiplex/AP Gel)in Decreasing Intrauterine Adhesions Completed NCT01377779 Not Applicable Oxiplex/AP gel;Normal Saline
19 Impact of Mindfulness Based Stress Reduction on Anxiety, Depression and QOL in Women With Intrauterine Adhesion. Completed NCT02746679 Not Applicable
20 Intrauterine Adhesion Rate After Hysteroscopic Myomectomy and Application of HYALOBARRIER Gel Completed NCT01412489 Not Applicable
21 Reproductive Outcome Affected by Two Adjunctive Treatments in Patients With Severe Intrauterine Adhesions Completed NCT02708277 Not Applicable
22 The Efficacy and Safety of Disposable Balloon Uterine Stent in Patients With Asherman Syndrome Recruiting NCT03330873 Not Applicable
23 Use of PRP in Endometrial Reconstruction Recruiting NCT03249415
24 Comparing Intra Uterine Synechiae Occurence Using Bipolar Energy Compared With Monopolar Energy in Myoma Resection on Women Having Menorraghia and/or Infertility Recruiting NCT02661087 Not Applicable
25 Intrauterine Balloon Therapy to Prevent the Recurrence of Intrauterine Adhesions Recruiting NCT03131596 Not Applicable
26 Comparing the Efficacy of Two Methods for the Therapy of Uterine Adhesion Recruiting NCT03329898 Not Applicable estradiol valerate tablets;dydrogesterone Tablets
27 Comparing the Efficacy of Two Methods in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis Recruiting NCT03346317 Not Applicable estradiol valerate tablets+dydrogesterone tablets
28 The Efficacy of Estrogen Therapy Against Adhesion Reformation After Hysteroscopic Adhesiolysis Recruiting NCT03351205 Not Applicable estradiol valerate tablets+dydrogesterone tablets
29 The Efficacy of G-CSF Against Adhesion Reformation After Hysteroscopic Adhesiolysis Recruiting NCT02855632 Not Applicable G-CSF;Normal saline;hormone therapy
30 Pre-clinical Endometrial Tissular Renovation Study Active, not recruiting NCT03665649 Not Applicable
31 Human Amniotic Epithelial Cell in Treatment of Refractory Severe Intrauterine Adhesion Not yet recruiting NCT03381807 Early Phase 1
32 Development of a Bioabsorbable Medical Device for the Prevention of Postoperative Intra-uterine Adhesions. Withdrawn NCT02328742

Search NIH Clinical Center for Asherman's Syndrome

Genetic Tests for Asherman's Syndrome

Anatomical Context for Asherman's Syndrome

MalaCards organs/tissues related to Asherman's Syndrome:

41
Uterus, Cervix, Bone, Placenta, Bone Marrow

Publications for Asherman's Syndrome

Articles related to Asherman's Syndrome:

(show top 50) (show all 122)
# Title Authors Year
1
Placenta Accreta following Hysteroscopic Lysis of Adhesions Caused by Asherman's Syndrome: A Case Report and Literature Review. ( 29955406 )
2018
2
Hysteroscopic Management of Asherman's Syndrome. ( 29024798 )
2018
3
The effect of endometrial thickness on pregnancy outcome in patients with Asherman's syndrome post-hysteroscopic adhesiolysis. ( 29483785 )
2018
4
Detection of Asherman's syndrome after conservative management of placenta accreta: a case report. ( 30454053 )
2018
5
Platelet-rich plasma in the management of Asherman syndrome: case report. ( 29455274 )
2018
6
Clinical and Reproductive Outcomes Following Hysteroscopic Adhesiolysis for Asherman Syndrome in an Asian Population. ( 29493709 )
2018
7
Stem cell therapy in Asherman syndrome and thin endometrium: Stem cell- based therapy. ( 29571018 )
2018
8
The association between menstrual cycle pattern and hysteroscopic march classification with endometrial thickness among infertile women with Asherman syndrome. ( 29979403 )
2018
9
The birth weight in pregnant women with Asherman syndrome compared to normal intrauterine cavity: A case-control study. ( 30095642 )
2018
10
Live birth rate and obstetric complications following the hysteroscopic management of intrauterine adhesions including Asherman syndrome. ( 30239778 )
2018
11
Bone Marrow Mesenchymal Stem Cells (BMSCs) Restore Functional Endometrium in the Rat Model for Severe Asherman Syndrome. ( 30458678 )
2018
12
Elevated NF-I_B signaling in Asherman syndrome patients and animal models. ( 28148903 )
2017
13
CXCL12 Promotes Stem Cell Recruitment and Uterine Repair after Injury in Asherman's Syndrome. ( 28345002 )
2017
14
A comprehensive review of Asherman's syndrome: causes, symptoms and treatment options. ( 28582327 )
2017
15
Anti-Mullerian hormone as a parameter for endometrial trauma in Asherman syndrome: A retrospective data analysis. ( 28400095 )
2017
16
Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating I9Np63 expression in Asherman's syndrome. ( 27921235 )
2016
17
Induction of Asherman's Syndrome in Rabbit. ( 26962478 )
2016
18
Autologous menstrual blood-derived stromal cells transplantation for severe Asherman's syndrome. ( 27664218 )
2016
19
Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman's syndrome and endometrial atrophy: a pilot cohort study. ( 27005892 )
2016
20
Reproductive Outcome of Patients With Asherman's Syndrome After Hysteroscopic Adhesiolysis. ( 27678984 )
2015
21
Reproductive Outcome of Patients with Asherman's Syndrome: A SAIMS Experience. ( 27110522 )
2015
22
Management of false passage created during hysteroscopic adhesiolysis for Asherman's syndrome. ( 26207696 )
2015
23
Treatment of Asherman's syndrome in an outpatient hysteroscopy setting. ( 25497164 )
2015
24
Placenta accreta: adherent placenta due to Asherman syndrome. ( 25838908 )
2015
25
A 10-year Review of the Clinical Presentation and Treatment Outcome of Asherman's Syndrome at a Center with Limited Resources. ( 27057384 )
2015
26
Treatment of Asherman's Syndrome in an Outpatient Hysteroscopy Setting. ( 27678648 )
2015
27
Human CD133(+) bone marrow-derived stem cells promote endometrial proliferation in a murine model of Asherman syndrome. ( 26384164 )
2015
28
Asherman syndrome: an unsolved clinical definition and management. ( 26484781 )
2015
29
A matched cohort study comparing the outcome of intrauterine adhesiolysis for Asherman's syndrome after uterine artery embolization or surgical trauma. ( 24842805 )
2014
30
Bone Marrow-Derived Stem Cell (BMDSC) transplantation improves fertility in a murine model of Asherman's syndrome. ( 24819371 )
2014
31
Curettage and Asherman's syndrome-lessons to (re-) learn? ( 25574677 )
2014
32
Autologous stem cell transplantation in refractory Asherman's syndrome: A novel cell based therapy. ( 25191021 )
2014
33
A rare case of Asherman's syndrome after open myomectomy: sonographic investigations and possible underlying mechanisms. ( 24557451 )
2014
34
Use of a hysteroscopic morcellator to resect miscarriage in a woman with recurrent Asherman's syndrome. ( 24865632 )
2014
35
Asherman syndrome in a Danish population. ( 24484072 )
2014
36
Effect of stem cell application on Asherman syndrome, an experimental rat model. ( 24974357 )
2014
37
Comprehensive treatment for infertile women with severe Asherman syndrome. ( 25286793 )
2014
38
Regenerating endometrium from stem/progenitor cells: is it abnormal in endometriosis, Asherman's syndrome and infertility? ( 23562953 )
2013
39
The Diagnosis and Management of Asherman's Syndrome Developed after Cesarean Section and Reproductive Outcome. ( 23840987 )
2013
40
Asherman's syndrome. ( 23600077 )
2013
41
Secondary amenorrhea in severe Asherman's syndrome: Step by step fertility retrieval by Bettocchi's hysteroscope: Some considerations. ( 24024657 )
2013
42
Role of 3D sonohysterography in the investigation of uterine synechiae/asherman's syndrome: Pictorial assay. ( 24314038 )
2013
43
Hysteroscopic adhesiolysis for patients with Asherman's syndrome: menstrual and fertility outcomes. ( 29662367 )
2013
44
A comparison of intrauterine balloon, intrauterine contraceptive device and hyaluronic acid gel in the prevention of adhesion reformation following hysteroscopic surgery for Asherman syndrome: a cohort study. ( 23932377 )
2013
45
The management of Asherman syndrome: a review of literature. ( 24373209 )
2013
46
Severe Asherman's syndrome complicated with placenta increta conceived by intracytoplasmic sperm injection following hysteroscopic surgery. ( 23444767 )
2012
47
Changes in endometrial receptivity in women with Asherman's syndrome undergoing hysteroscopic adhesiolysis. ( 22535194 )
2012
48
Comprehensive management of severe Asherman syndrome and amenorrhea. ( 22100167 )
2012
49
Reflections and potential clinical implication for the article "Separated from birth: an initial examination suggested Asherman's syndrome". ( 21345409 )
2011
50
Management of Asherman's syndrome. ( 21549641 )
2011

Variations for Asherman's Syndrome

Expression for Asherman's Syndrome

Search GEO for disease gene expression data for Asherman's Syndrome.

Pathways for Asherman's Syndrome

GO Terms for Asherman's Syndrome

Sources for Asherman's Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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