Aliases & Classifications for Askin's Tumor

MalaCards integrated aliases for Askin's Tumor:

Name: Askin's Tumor 12 15 74
Askin Tumor 12 17

Classifications:



External Ids:

Disease Ontology 12 DOID:0050608
UMLS 74 C0877849

Summaries for Askin's Tumor

Disease Ontology : 12 An Ewing sarcoma that arises from the soft tissues of the chest wall that tend to recur locally and not widely disseminated.

MalaCards based summary : Askin's Tumor, also known as askin tumor, is related to ewing sarcoma and adrenal neuroblastoma, and has symptoms including fever An important gene associated with Askin's Tumor is ENO2 (Enolase 2), and among its related pathways/superpathways are Apoptosis Modulation and Signaling and MAPK signaling pathway. The drugs Doxorubicin and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include bone, myeloid and lung, and related phenotypes are Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation and behavior/neurological

Wikipedia : 77 Akin''s tumor is a rare, primitive neuroectodermal tumor which arises from the soft tissues of the chest... more...

Related Diseases for Askin's Tumor

Diseases related to Askin's Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 ewing sarcoma 31.0 ENO2 EWSR1 MYC MYCN
2 adrenal neuroblastoma 10.2 ENO2 MYCN
3 nodular ganglioneuroblastoma 10.2 ENO2 MYCN
4 small cell osteogenic sarcoma 10.2 ENO2 EWSR1
5 central nervous system benign neoplasm 10.2 ENO2 MYCN
6 kidney rhabdoid cancer 10.2 ENO2 EWSR1
7 pericardium cancer 10.2 ENO2 MYCN
8 rhabdoid cancer 10.2 ENO2 EWSR1
9 cauda equina neoplasm 10.1 ENO2 EWSR1
10 extraosseous chondrosarcoma 10.1 ENO2 EWSR1
11 chondrosarcoma 10.1 ENO2 EWSR1
12 ewing's family of tumors 10.1
13 adult medulloblastoma 10.1 ENO2 MYCN
14 desmoplastic small round cell tumor 10.1 ENO2 EWSR1
15 extraskeletal ewing sarcoma 10.1 ENO2 EWSR1
16 neuroma 10.1 ENO2 NGF
17 cerebral neuroblastoma 10.1 ENO2 NGF
18 pediatric fibrosarcoma 10.1 EWSR1 NTRK1
19 chondrosarcoma, extraskeletal myxoid 10.1 ENO2 EWSR1
20 meningeal melanomatosis 10.1 ENO2 NGF
21 muscle cancer 10.1 ENO2 EWSR1
22 connective tissue cancer 10.0 ENO2 EWSR1
23 prolactin producing pituitary tumor 10.0 NGF NTRK1
24 blood group, kidd system 10.0
25 ataxia and polyneuropathy, adult-onset 10.0
26 pleuropulmonary blastoma 10.0
27 leukemia, acute myeloid 10.0
28 leukemia 10.0
29 scoliosis 10.0
30 sarcoma 10.0
31 neurofibrosarcoma 10.0
32 plasmacytoma 10.0
33 malignant peripheral nerve sheath tumor 10.0
34 myeloid leukemia 10.0
35 clear cell sarcoma 10.0 ENO2 EWSR1
36 conjunctival nevus 10.0 NGF NTRK1
37 neuropathy, hereditary sensory and autonomic, type v 10.0 NGF NTRK1
38 anhidrosis 10.0 NGF NTRK1
39 embryonal rhabdomyosarcoma 10.0 EWSR1 MYCN
40 ocular cicatricial pemphigoid 10.0 NGF NTRK1
41 cerebral cavernous malformations 2 9.9 NGF NTRK1
42 autonomic nervous system benign neoplasm 9.9 ENO2 MYCN NTRK1
43 ganglioneuroblastoma 9.9 ENO2 MYCN NTRK1
44 germ cell and embryonal cancer 9.9 ENO2 MYC
45 ganglioneuroma 9.9 ENO2 MYCN NTRK1
46 hereditary sensory neuropathy 9.9 NGF NTRK1
47 extraosseous ewing's sarcoma 9.9 ENO2 EWSR1 MYCN
48 rhabdomyosarcoma 9.9 ENO2 EWSR1 MYCN
49 rhabdomyosarcoma 2 9.9 ENO2 EWSR1 MYCN
50 childhood medulloblastoma 9.9 MYC MYCN

Graphical network of the top 20 diseases related to Askin's Tumor:



Diseases related to Askin's Tumor

Symptoms & Phenotypes for Askin's Tumor

UMLS symptoms related to Askin's Tumor:


fever

GenomeRNAi Phenotypes related to Askin's Tumor according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation GR00016-A 8.8 ENO2 MYCN NTRK1

MGI Mouse Phenotypes related to Askin's Tumor:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.55 ENO2 MYC MYCN NGF NTRK1
2 muscle MP:0005369 9.26 MYC MYCN NGF NTRK1
3 no phenotypic analysis MP:0003012 8.92 MYC MYCN NGF NTRK1

Drugs & Therapeutics for Askin's Tumor

Drugs for Askin's Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
2
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
3
Etoposide Approved Phase 2 33419-42-0 36462
4
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
5
Ifosfamide Approved Phase 2 3778-73-2 3690
6
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
7
Doxil Approved June 1999 Phase 2 31703
8 Pharmaceutical Solutions Phase 2
9 Mitogens Phase 2
10 Antibodies, Monoclonal Phase 2
11 Insulin, Globin Zinc Phase 2
12 Hypoglycemic Agents Phase 2
13 insulin Phase 2
14 Immunologic Factors Phase 2
15 Antibodies Phase 2
16 Immunoglobulins Phase 2
17 Antimitotic Agents Phase 2
18
Isophosphamide mustard Phase 2 0
19 Topoisomerase Inhibitors Phase 2
20 Alkylating Agents Phase 2
21 Antineoplastic Agents, Alkylating Phase 2
22 Antineoplastic Agents, Phytogenic Phase 2
23 Anti-Bacterial Agents Phase 2
24 Immunosuppressive Agents Phase 2
25 Etoposide phosphate Phase 2
26 Antirheumatic Agents Phase 2
27 Antibiotics, Antitubercular Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Zalypsis® (PM00104) in Patients With Unresectable Locally Advanced and/or Metastatic Ewing Family of Tumors (EFT) Progressing After at Least One Prior Line of Chemotherapy Completed NCT01222767 Phase 2 Zalypsis
2 QUILT-3.025: A Phase 2 Study of AMG 479 in Relapsed or Refractory Ewing's Family Tumor and Desmoplastic Small Round Cell Tumors Completed NCT00563680 Phase 2 AMG 479
3 Combination Chemotherapy and Radiation Therapy in Treating Patients With Peripheral Neuroectodermal Tumors, Ewing's Sarcoma, Wilms' Tumor, or Bone Cancer Completed NCT00002466 Phase 2 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
4 Pbi-shRNA™ EWS/FLI1 Type 1 LPX in Subjects With Advanced Ewing's Sarcoma Recruiting NCT02736565 Phase 1
5 Patterns of Care and Outcomes in Patients With Metastatic Bone Tumors (METABONE) Recruiting NCT03963531
6 Collecting and Storing Biological Samples From Patients With Ewing Sarcoma Active, not recruiting NCT00899990

Search NIH Clinical Center for Askin's Tumor

Genetic Tests for Askin's Tumor

Anatomical Context for Askin's Tumor

MalaCards organs/tissues related to Askin's Tumor:

42
Bone, Myeloid, Lung, Brain, Kidney, Pituitary, Thyroid

Publications for Askin's Tumor

Articles related to Askin's Tumor:

(show top 50) (show all 57)
# Title Authors Year
1
Surgical Treatment of Scoliosis Developed After Extended Chest Wall Resection Due to Askin Tumor During Childhood. ( 30587315 )
2019
2
From Ataxia to Diagnosis of Askin Tumor - a Case Report. ( 30216185 )
2018
3
Askin's Tumor. A Rare Diagnosis in an Elderly Patient. ( 28499589 )
2017
4
Askin's tumor: 11 cases and a review of the literature. ( 26870198 )
2016
5
Bilateral Synchronus Askin's Tumor- Case Report & Review of Literature. ( 27065698 )
2016
6
Askin tumor: A rare neoplasm of thoracopulmonary region. ( 27051109 )
2016
7
A small Askin's tumor presenting with early onset of chest pain. ( 25884603 )
2015
8
Rapidly fatal Askin's tumor: a case report and literature review. ( 25404964 )
2014
9
Askin tumor: CT and FDG-PET/CT imaging findings and follow-up. ( 25058144 )
2014
10
Askin tumor mimicking a hydatid cyst of the lung in children: case report. ( 25374636 )
2014
11
Askin's tumor: a case report and literature review. ( 23339634 )
2013
12
Role of F18 fluorodeoxyglucose positron-emission tomography/computed tomography in the management of Askin's tumor. ( 24250031 )
2013
13
Outcomes after interdisciplinary management of 7 patients with Askin tumor. ( 23397588 )
2013
14
Treatment of an Askin tumor: A case report and review of the literature. ( 24137450 )
2013
15
Askin's Tumor with Massive Hemoptysis. ( 25191404 )
2012
16
Suspected CNS Metastases of Askin's Tumor: Would You Irradiate the Neural Axis? ( 29147321 )
2012
17
Congenital Askin tumor with favorable outcome: case report and review of the literature. ( 22813811 )
2012
18
Nuclear scintigraphy findings for Askin tumor with In111-pentetreotide, Tc99m-MIBI and F18-FDG. ( 23378875 )
2012
19
Askin's Tumor: A Dual Case Study. ( 21792357 )
2011
20
A Case of Askin's Tumor Presenting with Pleural Effusion and High Level of Adenosine Deaminase. ( 22110310 )
2011
21
Costovertebral rib disarticulation and pleurectomy in Askin's tumor: a mandatory approach to radical surgery in children? Case report and guiedelines to surgical treatment. ( 22519201 )
2011
22
Askin tumor: four case reports and a review of the literature. ( 22138531 )
2011
23
Complete clinical response to neoadjuvant chemotherapy in a 54-year-old male with Askin tumor. ( 20680911 )
2010
24
Askin's tumor. ( 19634286 )
2009
25
Askin's Tumor in an Adult: Case Report and Findings on 18F-FDG PET/CT. ( 20049330 )
2009
26
Askin's tumor: a rare chest wall neoplasm. Case report and short review. ( 18615383 )
2008
27
Treatment planning comparison of electron arc therapy and photon intensity modulated radiotherapy for Askin's tumor of chest wall. ( 17719111 )
2007
28
Long-term survival of Askin tumor for 10 years with 2 relapses. ( 16702938 )
2006
29
Askin tumor with metastasis to the scalp: a histochemical, immunohistochemical and ultrastructural study. ( 17187186 )
2006
30
Newly established Askin tumor cell line and overexpression of focal adhesion kinase in Ewing sarcoma family of tumors cell lines. ( 14553943 )
2003
31
Synchronous presentation of an Askin tumor and a plasmacytoma in an adult patient. ( 12908792 )
2003
32
Activation of trkA induces differentiation and inhibits the growth of JK-GMS Askin tumor cells. ( 11850535 )
2002
33
The treatment of Askin tumor: results of two cases. ( 11828318 )
2002
34
Giant Askin tumor: a diagnosis and therapeutic challenge. ( 12073717 )
2002
35
Successful use of intraoperative radiotherapy for local control of an Askin's tumor recurrence. ( 11292924 )
2001
36
Askin tumor: a malignant small cell tumor. ( 11216390 )
2000
37
Malignant small cell (Askin) tumor of the thoracopulmonary region originating from the phrenic nerve. ( 10425016 )
1999
38
Diagnosis in oncology. Askin tumor. ( 9586920 )
1998
39
Askin tumor and acute myeloid leukemia in a patient with constitutional partial Y disomy. ( 9595038 )
1998
40
Long-term survival after repeated resections of Askin tumor recurrences. ( 9628384 )
1998
41
Gallium and thallium scintigraphy in pediatric peripheral primitive neuroectodermal tumor (Askin tumor) of the chest wall. ( 7738655 )
1995
42
Askin's tumor of the chest wall: a case report in an adult. ( 8127136 )
1994
43
Peripheral neuroectodermal tumor of the chest (Askin tumor) as secondary neoplasm after Hodgkin's disease: a case report. ( 8038238 )
1994
44
Fine needle aspiration cytologic findings in malignant small cell tumor of the thoracopulmonary region (Askin tumor). ( 8091901 )
1994
45
[A case of primitive neuroectodermal tumor in the chest wall ("Askin's tumor")]. ( 8176303 )
1994
46
Superior results with complete resection of Askin's tumor. ( 8488358 )
1993
47
Massive chest wall tumor diagnosed as Askin tumor. Successful treatment by intensive combined modality therapy in an adult. ( 8325087 )
1993
48
Diagnostic features and treatment of the Askin tumor--malignant small cell tumor of the thoraco-pulmonary region: a case report. ( 8381214 )
1993
49
Translocation (5;22) in an Askin's tumor. ( 1394111 )
1992
50
Does malignant small round cell tumor of the thoracopulmonary region (Askin tumor) constitute a clinicopathologic entity? An analysis of 30 cases with immunohistochemical and electron-microscopic support treated at the Institute Gustave Roussy. ( 1310431 )
1992

Variations for Askin's Tumor

Cosmic variations for Askin's Tumor:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM1745010 MYOD1 soft tissue,chest wall,rhabdomyosarcoma,NS c.365T>G p.L122R 11:17720147-17720147 0

Expression for Askin's Tumor

Search GEO for disease gene expression data for Askin's Tumor.

Pathways for Askin's Tumor

Pathways related to Askin's Tumor according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.4 MYC NGF NTRK1
2 12.34 MYC NGF NTRK1
3 11.79 ENO2 MYCN NGF NTRK1
4
Show member pathways
11.75 MYC NGF NTRK1
5
Show member pathways
11.68 MYC NGF NTRK1
6
Show member pathways
11.4 NGF NTRK1
7 11.3 MYC MYCN
8 11.27 MYC NTRK1
9
Show member pathways
11.22 NGF NTRK1
10 11.19 EWSR1 MYC MYCN NTRK1
11 11.06 NGF NTRK1
12
Show member pathways
10.3 NGF NTRK1
13 9.85 MYC MYCN

GO Terms for Askin's Tumor

Biological processes related to Askin's Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.61 MYC NGF NTRK1
2 positive regulation of gene expression GO:0010628 9.58 MYC MYCN NGF
3 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.46 NGF NTRK1
4 activation of MAPKK activity GO:0000186 9.37 NGF NTRK1
5 phosphatidylinositol-mediated signaling GO:0048015 9.32 NGF NTRK1
6 positive regulation of DNA binding GO:0043388 9.26 MYC NGF
7 neurotrophin TRK receptor signaling pathway GO:0048011 9.16 NGF NTRK1
8 positive regulation of Ras protein signal transduction GO:0046579 8.96 NGF NTRK1
9 nerve growth factor signaling pathway GO:0038180 8.62 NGF NTRK1

Molecular functions related to Askin's Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase binding GO:0019900 8.62 MYCN NTRK1

Sources for Askin's Tumor

3 CDC
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75 UMLS via Orphanet
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