MCID: ASK001
MIFTS: 36

Askin's Tumor

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Askin's Tumor

MalaCards integrated aliases for Askin's Tumor:

Name: Askin's Tumor 12 15 71
Askin Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050608
UMLS 71 C0877849

Summaries for Askin's Tumor

Disease Ontology : 12 An Ewing sarcoma that arises from the soft tissues of the chest wall that tend to recur locally and not widely disseminated.

MalaCards based summary : Askin's Tumor, also known as askin tumor, is related to clear cell sarcoma and neuroblastoma, and has symptoms including fever An important gene associated with Askin's Tumor is ENO2 (Enolase 2), and among its related pathways/superpathways are Neuroscience and NGF Pathway. The drugs Etoposide and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and pancreas, and related phenotypes are growth/size/body region and muscle

Related Diseases for Askin's Tumor

Diseases related to Askin's Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Related Disease Score Top Affiliating Genes
1 clear cell sarcoma 30.1 SYP EWSR1 ENO2
2 neuroblastoma 28.9 SYP PTK2 NTRK1 NGF MYCN MYC
3 ewing sarcoma 28.3 SYP PTK2 MYCN MYC FLII FLI1
4 rare tumor 10.5
5 kidney rhabdoid cancer 10.4 EWSR1 ENO2
6 ectomesenchymoma 10.3 ENO2 CD99
7 malignant melanocytic neoplasm of the peripheral nerve sheath 10.3 SYP ENO2
8 extracranial neuroblastoma 10.3 MYCN EWSR1
9 ureter small cell carcinoma 10.3 SYP ENO2
10 anal neuroendocrine tumor 10.3 SYP ENO2
11 sinonasal undifferentiated carcinoma 10.3 SYP ENO2
12 cerebral neuroblastoma 10.3 SYP ENO2
13 papillary tumor of the pineal region 10.3 SYP ENO2
14 small cell carcinoma of the bladder 10.3 SYP ENO2
15 urinary bladder small cell neuroendocrine carcinoma 10.3 SYP ENO2
16 desmoplastic infantile ganglioglioma 10.3 SYP MYCN
17 bile duct mucinous adenocarcinoma 10.3 SYP ENO2
18 nodular prostate 10.3 SYP ENO2
19 appendix carcinoid tumor 10.3 SYP ENO2
20 extraskeletal mesenchymal chondrosarcoma 10.3 EWSR1 CD99
21 auditory system cancer 10.3 SYP ENO2
22 cloacogenic carcinoma 10.3 SYP ENO2
23 thymus small cell carcinoma 10.3 SYP ENO2
24 ewing sarcoma of bone 10.3 EWSR1 CD99
25 mature teratoma of the ovary 10.3 SYP ENO2
26 duodenal benign neoplasm 10.3 SYP ENO2
27 ampulla of vater neoplasm 10.3 SYP ENO2
28 cerebellar liponeurocytoma 10.3 SYP ENO2
29 papillary ependymoma 10.3 SYP ENO2
30 middle ear adenoma 10.3 SYP ENO2
31 optic nerve astrocytoma 10.3 SYP ENO2
32 carotid body cancer 10.3 SYP ENO2
33 gastric small cell carcinoma 10.3 SYP ENO2
34 jejunal neoplasm 10.3 SYP ENO2
35 vulva basal cell carcinoma 10.3 SYP MYC
36 sensory organ benign neoplasm 10.3 SYP ENO2
37 subependymoma 10.3 SYP ENO2
38 pineocytoma 10.3 SYP ENO2
39 pediatric fibrosarcoma 10.3 NTRK1 EWSR1
40 central nervous system mesenchymal non-meningothelial tumor 10.3 EWSR1 CD99
41 cervical large cell neuroendocrine carcinoma 10.3 SYP ENO2
42 lung oat cell carcinoma 10.3 SYP ENO2
43 pineal parenchymal tumor of intermediate differentiation 10.3 SYP ENO2
44 cutaneous ganglioneuroma 10.3 SYP ENO2
45 endometrial small cell carcinoma 10.3 SYP ENO2
46 neuropathy, hereditary sensory and autonomic, type v 10.3 NTRK1 NGF
47 cervix small cell carcinoma 10.3 SYP ENO2
48 vaginal endometrial stromal sarcoma 10.3 SYP ENO2
49 carcinoid tumors, intestinal 10.2 SYP ENO2
50 ocular cicatricial pemphigoid 10.2 NTRK1 NGF

Graphical network of the top 20 diseases related to Askin's Tumor:



Diseases related to Askin's Tumor

Symptoms & Phenotypes for Askin's Tumor

UMLS symptoms related to Askin's Tumor:


fever

MGI Mouse Phenotypes related to Askin's Tumor:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.91 ENO2 ETV1 FLI1 FLII MYC MYCN
2 muscle MP:0005369 9.76 ETV1 ETV4 FLI1 MYC MYCN NGF
3 nervous system MP:0003631 9.65 ENO2 ETV1 ETV4 FLI1 MYC MYCN
4 normal MP:0002873 9.17 ETV1 MYC MYCN NGF NTRK1 PTK2

Drugs & Therapeutics for Askin's Tumor

Drugs for Askin's Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 2 33419-42-0 36462
2
Cyclophosphamide Approved, Investigational Phase 2 6055-19-2, 50-18-0 2907
3
Vincristine Approved, Investigational Phase 2 57-22-7, 2068-78-2 5978
4
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
5
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
6
Ifosfamide Approved Phase 2 3778-73-2 3690
7 Alkylating Agents Phase 2
8 Immunologic Factors Phase 2
9 Etoposide phosphate Phase 2
10 Anti-Bacterial Agents Phase 2
11 Immunosuppressive Agents Phase 2
12 Antibiotics, Antitubercular Phase 2
13 Antimitotic Agents Phase 2
14 Topoisomerase Inhibitors Phase 2
15 Antirheumatic Agents Phase 2
16
Liposomal doxorubicin Phase 2 31703
17
Isophosphamide mustard Phase 2 0

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study of Cyclophosphamide, Doxorubicin, Vincristine, Etoposide, and Ifosfamide, Followed by Resection and Radiotherapy in Patients With Peripheral Primitive Neuroectodermal Tumors or Ewing's Sarcoma Completed NCT00002466 Phase 2 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
2 Phase I Trial of Pbi-shRNA™ EWS/FLI1 Type 1 Lipoplex (LPX) in Subjects With Advanced Ewing's Sarcoma Recruiting NCT02736565 Phase 1
3 Patterns of Care and Outcomes of Patients With METAstatic BONE Tumors in a Real-life Setting Recruiting NCT03963531
4 A COG Study for Collecting and Banking Ewing Sarcoma Specimens Active, not recruiting NCT00899990

Search NIH Clinical Center for Askin's Tumor

Genetic Tests for Askin's Tumor

Anatomical Context for Askin's Tumor

MalaCards organs/tissues related to Askin's Tumor:

40
Bone, Lung, Pancreas, Myeloid, T Cells, Liver, Breast

Publications for Askin's Tumor

Articles related to Askin's Tumor:

(show top 50) (show all 162)
# Title Authors PMID Year
1
Askin's tumor in an elderly patient. 61
31490006 2019
2
Primary Intra-abdominal Ewing's Sarcoma in Adults: A Multimodality Imaging Spectrum. 61
30642618 2019
3
Surgical Treatment of Scoliosis Developed After Extended Chest Wall Resection Due to Askin Tumor During Childhood. 61
30587315 2019
4
From Ataxia to Diagnosis of Askin Tumor - a Case Report. 61
30216185 2018
5
Comparison of clinical features and outcomes in patients with extraskeletal vs skeletal Ewing sarcoma: an SEER database analysis of 3,178 cases. 61
30538569 2018
6
Askin's Tumor. A Rare Diagnosis in an Elderly Patient. 61
28499589 2017
7
Molecular cytogenetic characterization of two established ESFT cell lines. 61
27613543 2017
8
Askin tumor: A rare neoplasm of thoracopulmonary region. 61
27051109 2016
9
Askin (PNET) Tumor Unmasked by Trauma in a Young Male Patient. 61
27731566 2016
10
Bilateral Synchronus Askin's Tumor- Case Report & Review of Literature. 61
27065698 2016
11
Askin's tumor: 11 cases and a review of the literature. 61
26870198 2016
12
Multimodality Treatment in Ewing's Sarcoma Family Tumors of the Maxilla and Maxillary Sinus: Review of the Literature. 61
27413360 2016
13
Clinical features and outcomes of infants with Ewing sarcoma under 12 months of age. 61
26173989 2015
14
High-dose Thiotepa as Consolidation Therapy With Autologous Hematopoietic Stem Cell Transplantation for High-risk Ewing Family Tumors: Single-institution Experience. 61
26207773 2015
15
Locally Advanced Askin's Tumour in a Child-a Rare Case Report and Review of the Literature. 61
27217682 2015
16
A small Askin's tumor presenting with early onset of chest pain. 61
25884603 2015
17
Askin tumor: CT and FDG-PET/CT imaging findings and follow-up. 61
25058144 2014
18
Askin tumor mimicking a hydatid cyst of the lung in children: case report. 61
25374636 2014
19
[Rare observation of giant Askin's tumor with localization in anterior mediastinum]. 61
25823315 2014
20
Rapidly fatal Askin's tumor: a case report and literature review. 61
25404964 2014
21
Treatment of an Askin tumor: A case report and review of the literature. 61
24137450 2013
22
[Long-term survival case of primitive neuroectodermal tumor in the chest wall of a young adult]. 61
24105117 2013
23
Role of F18 fluorodeoxyglucose positron-emission tomography/computed tomography in the management of Askin's tumor. 61
24250031 2013
24
Primary primitive neuroectodermal tumor of the breast: a rare case presentation. 61
24426592 2013
25
Outcomes after interdisciplinary management of 7 patients with Askin tumor. 61
23397588 2013
26
From the radiologic pathology archives: ewing sarcoma family of tumors: radiologic-pathologic correlation. 61
23674776 2013
27
Askin's tumor: a case report and literature review. 61
23339634 2013
28
Suspected CNS Metastases of Askin's Tumor: Would You Irradiate the Neural Axis? 61
29147321 2012
29
EWS-FLI-1-targeted cytotoxic T-cell killing of multiple tumor types belonging to the Ewing sarcoma family of tumors. 61
22879388 2012
30
Nuclear scintigraphy findings for Askin tumor with In111-pentetreotide, Tc99m-MIBI and F18-FDG. 61
23378875 2012
31
Extraosseous Ewing's sarcoma of the pancreas. 61
21892669 2012
32
Congenital Askin tumor with favorable outcome: case report and review of the literature. 61
22813811 2012
33
Askin's Tumor with Massive Hemoptysis. 61
25191404 2012
34
Askin tumor: four case reports and a review of the literature. 61
22138531 2011
35
A Case of Askin's Tumor Presenting with Pleural Effusion and High Level of Adenosine Deaminase. 61
22110310 2011
36
Askin's Tumor: A Dual Case Study. 61
21792357 2011
37
Costovertebral rib disarticulation and pleurectomy in Askin's tumor: a mandatory approach to radical surgery in children? Case report and guiedelines to surgical treatment. 61
22519201 2011
38
Late surgery for spinal deformities in children previously treated for neural tumors. 61
21328191 2011
39
Complete clinical response to neoadjuvant chemotherapy in a 54-year-old male with Askin tumor. 61
20680911 2010
40
Epigenetic modifiers as anticancer drugs: effectiveness of valproic acid in neural crest-derived tumor cells. 61
20332466 2010
41
[Use of LAK-cells and systemic chemotherapy with hyperthermia in the management of chemo-resistant tumors]. 61
21395124 2010
42
[Askin tumor: a case report with literature review]. 61
19692278 2009
43
[Efficacy and survival of 92 cases of Ewing's sarcoma family of tumor initially treated with multidisciplinary therapy]. 61
19958626 2009
44
[Solution to case 9. Askin tumor]. 61
19800487 2009
45
Askin's tumor. 61
19634286 2009
46
Ewing's sarcoma: standard and experimental treatment options. 61
19533369 2009
47
Askin's Tumor in an Adult: Case Report and Findings on 18F-FDG PET/CT. 61
20049330 2009
48
Askin's tumor: a rare chest wall neoplasm. Case report and short review. 61
18615383 2008
49
Interaction between ERK and GSK3beta mediates basic fibroblast growth factor-induced apoptosis in SK-N-MC neuroblastoma cells. 61
18263590 2008
50
Ewing's sarcoma family of tumors: an overview from diagnosis to survivorship. 61
18258578 2008

Variations for Askin's Tumor

Expression for Askin's Tumor

Search GEO for disease gene expression data for Askin's Tumor.

Pathways for Askin's Tumor

Pathways related to Askin's Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.89 SYP NTRK1 NGF MYCN ENO2
2
Show member pathways
11.68 NTRK1 NGF MYC
3 11.49 PTK2 NTRK1 MYCN MYC FLI1 EWSR1
4
Show member pathways
10.3 NTRK1 NGF
5 9.85 MYCN MYC

GO Terms for Askin's Tumor

Cellular components related to Askin's Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.02 MYCN MYC FLI1 ETV4 ETV1

Biological processes related to Askin's Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.73 MYCN MYC FLI1 EWSR1 ETV4 ETV1
2 regulation of transcription by RNA polymerase II GO:0006357 9.35 MYCN MYC FLI1 ETV4 ETV1
3 positive regulation of Ras protein signal transduction GO:0046579 9.32 NTRK1 NGF
4 neurotrophin TRK receptor signaling pathway GO:0048011 9.16 NTRK1 NGF
5 nerve growth factor signaling pathway GO:0038180 8.62 NTRK1 NGF

Molecular functions related to Askin's Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.65 MYCN MYC FLI1 ETV4 ETV1
2 DNA-binding transcription factor activity GO:0003700 9.55 MYCN MYC FLI1 ETV4 ETV1
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.35 MYCN MYC FLI1 ETV4 ETV1
4 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.02 MYCN MYC FLI1 ETV4 ETV1

Sources for Askin's Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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