Aliases & Classifications for Askin's Tumor

MalaCards integrated aliases for Askin's Tumor:

Name: Askin's Tumor 12 15 73
Askin Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050608

Summaries for Askin's Tumor

MalaCards based summary : Askin's Tumor, also known as askin tumor, is related to ewing sarcoma and adrenal neuroblastoma, and has symptoms including fever An important gene associated with Askin's Tumor is ENO2 (Enolase 2), and among its related pathways/superpathways are Apoptosis Modulation and Signaling and MAPK signaling pathway. The drugs Cyclophosphamide and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation and behavior/neurological

Wikipedia : 76 Akin\'s tumor is a rare, primitive neuroectodermal tumor which arises from the soft tissues of the chest... more...

Related Diseases for Askin's Tumor

Diseases related to Askin's Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 ewing sarcoma 31.6 ENO2 EWSR1 MYC MYCN
2 adrenal neuroblastoma 10.4 ENO2 MYCN
3 nodular ganglioneuroblastoma 10.4 ENO2 MYCN
4 small cell osteogenic sarcoma 10.3 ENO2 EWSR1
5 orbital cancer 10.3 ENO2 EWSR1
6 kidney rhabdoid cancer 10.3 ENO2 EWSR1
7 pericardium cancer 10.3 ENO2 MYCN
8 cauda equina neoplasm 10.3 ENO2 EWSR1
9 extraosseous chondrosarcoma 10.3 ENO2 EWSR1
10 adult medulloblastoma 10.3 ENO2 MYCN
11 desmoplastic small round cell tumor 10.3 ENO2 EWSR1
12 extraskeletal ewing sarcoma 10.3 ENO2 EWSR1
13 chondrosarcoma, extraskeletal myxoid 10.2 ENO2 EWSR1
14 muscle cancer 10.2 ENO2 EWSR1
15 connective tissue cancer 10.1 ENO2 EWSR1
16 clear cell sarcoma 10.1 ENO2 EWSR1
17 childhood medulloblastoma 10.0 MYC MYCN
18 infratentorial cancer 10.0 MYC MYCN
19 cerebral neuroblastoma 10.0 ENO2 NGF
20 embryonal rhabdomyosarcoma 10.0 EWSR1 MYCN
21 meningeal melanomatosis 9.9 ENO2 NGF
22 traumatic brain injury 9.9 ENO2 NGF
23 pleuropulmonary blastoma 9.9
24 sarcoma 9.9
25 neurofibrosarcoma 9.9
26 malignant peripheral nerve sheath tumor 9.9
27 neurofibroma 9.9
28 ewing's family of tumors 9.9
29 neuropathy, hereditary sensory and autonomic, type v 9.9 NGF NTRK1
30 ganglioneuroblastoma 9.8 ENO2 MYCN NTRK1
31 prolactin producing pituitary tumor 9.8 NGF NTRK1
32 ganglioneuroma 9.8 ENO2 MYCN NTRK1
33 extraosseous ewing's sarcoma 9.8 ENO2 EWSR1 MYCN
34 rhabdomyosarcoma 2 9.8 ENO2 EWSR1 MYCN
35 conjunctival nevus 9.8 NGF NTRK1
36 sweat gland disease 9.8 NGF NTRK1
37 olfactory neuroblastoma 9.7 ENO2 EWSR1 NTRK1
38 rhabdomyosarcoma 9.7 ENO2 EWSR1 MYCN
39 anhidrosis 9.7 NGF NTRK1
40 thyroid carcinoma, familial medullary 9.7 ENO2 NTRK1
41 respiratory system cancer 9.7 ENO2 MYC
42 ocular cicatricial pemphigoid 9.7 NGF NTRK1
43 cerebral primitive neuroectodermal tumor 9.7 ENO2 MYC MYCN
44 medullomyoblastoma 9.7 ENO2 MYC MYCN
45 neuroma 9.7 ENO2 NGF
46 small cell cancer of the lung 9.7 ENO2 MYC MYCN
47 cerebral cavernous malformations 2 9.6 NGF NTRK1
48 hereditary sensory neuropathy 9.6 NGF NTRK1
49 cell type cancer 9.6 ENO2 EWSR1 MYC
50 autonomic neuropathy 9.5 NGF NTRK1

Graphical network of the top 20 diseases related to Askin's Tumor:



Diseases related to Askin's Tumor

Symptoms & Phenotypes for Askin's Tumor

UMLS symptoms related to Askin's Tumor:


fever

GenomeRNAi Phenotypes related to Askin's Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation GR00016-A 8.8 ENO2 MYCN NTRK1

MGI Mouse Phenotypes related to Askin's Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.55 NGF NTRK1 ENO2 MYC MYCN
2 muscle MP:0005369 9.26 NGF NTRK1 MYC MYCN
3 no phenotypic analysis MP:0003012 8.92 NTRK1 MYC MYCN NGF

Drugs & Therapeutics for Askin's Tumor

Drugs for Askin's Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
2
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
3
Etoposide Approved Phase 2 33419-42-0 36462
4
Ifosfamide Approved Phase 2 3778-73-2 3690
5
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
6
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
7
Doxil Approved June 1999 Phase 2 31703
8 Pharmaceutical Solutions Phase 2
9 Antibodies Phase 2
10 Antibodies, Monoclonal Phase 2
11 Hypoglycemic Agents Phase 2
12 Immunoglobulins Phase 2
13 insulin Phase 2
14 Insulin, Globin Zinc Phase 2
15 Mitogens Phase 2
16 Alkylating Agents Phase 2
17 Anti-Bacterial Agents Phase 2
18 Antibiotics, Antitubercular Phase 2
19 Antimitotic Agents Phase 2
20 Antineoplastic Agents, Alkylating Phase 2
21 Antineoplastic Agents, Phytogenic Phase 2
22 Antirheumatic Agents Phase 2
23 Etoposide phosphate Phase 2
24 Immunosuppressive Agents Phase 2
25
Isophosphamide mustard Phase 2 0
26 Topoisomerase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Zalypsis® (PM00104) in Patients With Unresectable Locally Advanced and/or Metastatic Ewing Family of Tumors (EFT) Progressing After at Least One Prior Line of Chemotherapy Completed NCT01222767 Phase 2 Zalypsis
2 QUILT-3.025: A Phase 2 Study of AMG 479 in Relapsed or Refractory Ewing's Family Tumor and Desmoplastic Small Round Cell Tumors Completed NCT00563680 Phase 2 AMG 479
3 Combination Chemotherapy and Radiation Therapy in Treating Patients With Peripheral Neuroectodermal Tumors, Ewing's Sarcoma, Wilms' Tumor, or Bone Cancer Completed NCT00002466 Phase 2 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
4 Pbi-shRNA™ EWS/FLI1 Type 1 LPX in Subjects With Advanced Ewing's Sarcoma Active, not recruiting NCT02736565 Phase 1
5 Collecting and Storing Biological Samples From Patients With Ewing Sarcoma Active, not recruiting NCT00899990

Search NIH Clinical Center for Askin's Tumor

Genetic Tests for Askin's Tumor

Anatomical Context for Askin's Tumor

MalaCards organs/tissues related to Askin's Tumor:

41
Bone

Publications for Askin's Tumor

Articles related to Askin's Tumor:

(show all 22)
# Title Authors Year
1
Askin's Tumor. A Rare Diagnosis in an Elderly Patient. ( 28499589 )
2017
2
Askin's tumor: 11 cases and a review of the literature. ( 26870198 )
2016
3
Bilateral Synchronus Askin's Tumor- Case Report & Review of Literature. ( 27065698 )
2016
4
A small Askin's tumor presenting with early onset of chest pain. ( 25884603 )
2015
5
Rapidly fatal Askin's tumor: a case report and literature review. ( 25404964 )
2014
6
Askin's tumor: a case report and literature review. ( 23339634 )
2013
7
Role of F18 fluorodeoxyglucose positron-emission tomography/computed tomography in the management of Askin's tumor. ( 24250031 )
2013
8
Askin's Tumor with Massive Hemoptysis. ( 25191404 )
2012
9
Suspected CNS Metastases of Askin's Tumor: Would You Irradiate the Neural Axis? ( 29147321 )
2012
10
A Case of Askin's Tumor Presenting with Pleural Effusion and High Level of Adenosine Deaminase. ( 22110310 )
2011
11
Askin's Tumor: A Dual Case Study. ( 21792357 )
2011
12
Costovertebral rib disarticulation and pleurectomy in Askin's tumor: a mandatory approach to radical surgery in children? Case report and guiedelines to surgical treatment. ( 22519201 )
2011
13
Askin's tumor. ( 19634286 )
2009
14
Askin's Tumor in an Adult: Case Report and Findings on 18F-FDG PET/CT. ( 20049330 )
2009
15
Askin's tumor: a rare chest wall neoplasm. Case report and short review. ( 18615383 )
2008
16
Treatment planning comparison of electron arc therapy and photon intensity modulated radiotherapy for Askin's tumor of chest wall. ( 17719111 )
2007
17
Successful use of intraoperative radiotherapy for local control of an Askin's tumor recurrence. ( 11292924 )
2001
18
Askin's tumor of the chest wall: a case report in an adult. ( 8127136 )
1994
19
Superior results with complete resection of Askin's tumor. ( 8488358 )
1993
20
Translocation (5;22) in an Askin's tumor. ( 1394111 )
1992
21
MRI of Askin's tumor. Case report at 1.5 T. ( 2331925 )
1990
22
Progression of chromosome abnormalities after radiation therapy in a patient with Askin's tumor. ( 2162733 )
1990

Variations for Askin's Tumor

Cosmic variations for Askin's Tumor:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM1745010 MYOD1 soft tissue,chest wall,rhabdomyosarcoma,NS c.365T>G p.L122R 11:17720147-17720147 3

Expression for Askin's Tumor

Search GEO for disease gene expression data for Askin's Tumor.

Pathways for Askin's Tumor

GO Terms for Askin's Tumor

Biological processes related to Askin's Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.63 MYC NGF NTRK1
2 positive regulation of gene expression GO:0010628 9.61 MYC MYCN NGF
3 activation of MAPKK activity GO:0000186 9.4 NGF NTRK1
4 phosphatidylinositol-mediated signaling GO:0048015 9.37 NGF NTRK1
5 positive regulation of DNA binding GO:0043388 9.32 MYC NGF
6 positive regulation of mesenchymal cell proliferation GO:0002053 9.26 MYC MYCN
7 positive regulation of Ras protein signal transduction GO:0046579 9.16 NGF NTRK1
8 neurotrophin TRK receptor signaling pathway GO:0048011 8.96 NGF NTRK1
9 nerve growth factor signaling pathway GO:0038180 8.62 NGF NTRK1

Molecular functions related to Askin's Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase binding GO:0019900 8.62 MYCN NTRK1

Sources for Askin's Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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