MCID: ASK001
MIFTS: 35

Askin's Tumor

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Askin's Tumor

MalaCards integrated aliases for Askin's Tumor:

Name: Askin's Tumor 12 15 72
Askin Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050608
UMLS 72 C0877849

Summaries for Askin's Tumor

Disease Ontology : 12 An Ewing sarcoma that arises from the soft tissues of the chest wall that tend to recur locally and not widely disseminated.

MalaCards based summary : Askin's Tumor, also known as askin tumor, is related to ewing sarcoma and clear cell sarcoma, and has symptoms including fever An important gene associated with Askin's Tumor is ENO2 (Enolase 2), and among its related pathways/superpathways are Apoptosis Modulation and Signaling and MAPK signaling pathway. The drugs Ifosfamide and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and pancreas, and related phenotypes are Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation and no phenotypic analysis

Related Diseases for Askin's Tumor

Diseases related to Askin's Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 ewing sarcoma 31.3 MYCN MYC EWSR1 ENO2
2 clear cell sarcoma 29.7 EWSR1 ENO2
3 ewing's family of tumors 11.7
4 rare tumor 10.5
5 adrenal neuroblastoma 10.4 MYCN ENO2
6 nodular ganglioneuroblastoma 10.4 MYCN ENO2
7 central nervous system benign neoplasm 10.3 MYCN ENO2
8 pericardium cancer 10.3 MYCN ENO2
9 neuroblastoma 1 10.3
10 neuroma 10.3 NGF ENO2
11 adult medulloblastoma 10.3 MYCN ENO2
12 cerebral neuroblastoma 10.3 NGF ENO2
13 germ cell and embryonal cancer 10.2 MYC ENO2
14 meningeal melanomatosis 10.2 NGF ENO2
15 childhood medulloblastoma 10.2 MYCN MYC
16 infratentorial cancer 10.2 MYCN MYC
17 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
18 ataxia and polyneuropathy, adult-onset 10.1
19 pleuropulmonary blastoma 10.1
20 leukemia, acute myeloid 10.1
21 scoliosis 10.1
22 pulmonary tuberculosis 10.1
23 plasmacytoma 10.1
24 pleural empyema 10.1
25 embryoma 10.1
26 malignant peripheral nerve sheath tumor 10.1
27 myeloid leukemia 10.1
28 diabetes insipidus 10.1
29 chromosomal triplication 10.1
30 prolactin producing pituitary tumor 10.0 NTRK1 NGF
31 conjunctival nevus 10.0 NTRK1 NGF
32 small cell osteogenic sarcoma 10.0 EWSR1 ENO2
33 neuropathy, hereditary sensory and autonomic, type v 10.0 NTRK1 NGF
34 cerebral primitive neuroectodermal tumor 10.0 MYCN MYC ENO2
35 cauda equina neoplasm 10.0 EWSR1 ENO2
36 medullomyoblastoma 10.0 MYCN MYC ENO2
37 kidney rhabdoid cancer 10.0 EWSR1 ENO2
38 rhabdoid cancer 10.0 EWSR1 ENO2
39 extraosseous chondrosarcoma 10.0 EWSR1 ENO2
40 central nervous system cancer 10.0 MYCN MYC ENO2
41 anhidrosis 10.0 NTRK1 NGF
42 small cell cancer of the lung 10.0 MYCN MYC ENO2
43 desmoplastic small round cell tumor 10.0 EWSR1 ENO2
44 extraskeletal ewing sarcoma 9.9 EWSR1 ENO2
45 ocular cicatricial pemphigoid 9.9 NTRK1 NGF
46 nervous system disease 9.9 NGF MYCN ENO2
47 chondrosarcoma, extraskeletal myxoid 9.9 EWSR1 ENO2
48 cerebral cavernous malformations 2 9.9 NTRK1 NGF
49 autonomic nervous system benign neoplasm 9.8 NTRK1 MYCN ENO2
50 brain cancer 9.8 MYCN MYC ENO2

Graphical network of the top 20 diseases related to Askin's Tumor:



Diseases related to Askin's Tumor

Symptoms & Phenotypes for Askin's Tumor

UMLS symptoms related to Askin's Tumor:


fever

GenomeRNAi Phenotypes related to Askin's Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation GR00016-A 8.8 ENO2 MYCN NTRK1

MGI Mouse Phenotypes related to Askin's Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 8.92 MYC MYCN NGF NTRK1

Drugs & Therapeutics for Askin's Tumor

Drugs for Askin's Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ifosfamide Approved Phase 2 3778-73-2 3690
2
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
3
Vincristine Approved, Investigational Phase 2 57-22-7, 2068-78-2 5978
4
Etoposide Approved Phase 2 33419-42-0 36462
5
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
6
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
7 Tubulin Modulators Phase 2
8 Alkylating Agents Phase 2
9
Liposomal doxorubicin Phase 2 31703
10 Antineoplastic Agents, Phytogenic Phase 2
11 Anti-Bacterial Agents Phase 2
12 Immunosuppressive Agents Phase 2
13 Antibiotics, Antitubercular Phase 2
14 Topoisomerase Inhibitors Phase 2
15 Immunologic Factors Phase 2
16
Isophosphamide mustard Phase 2 0
17 Etoposide phosphate Phase 2
18 Antimitotic Agents Phase 2
19 Antirheumatic Agents Phase 2
20 Antineoplastic Agents, Alkylating Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study of Cyclophosphamide, Doxorubicin, Vincristine, Etoposide, and Ifosfamide, Followed by Resection and Radiotherapy in Patients With Peripheral Primitive Neuroectodermal Tumors or Ewing's Sarcoma Completed NCT00002466 Phase 2 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
2 Phase I Trial of Pbi-shRNA™ EWS/FLI1 Type 1 Lipoplex (LPX) in Subjects With Advanced Ewing's Sarcoma Recruiting NCT02736565 Phase 1
3 Patterns of Care and Outcomes of Patients With METAstatic BONE Tumors in a Real-life Setting Recruiting NCT03963531
4 A COG Study for Collecting and Banking Ewing Sarcoma Specimens Active, not recruiting NCT00899990

Search NIH Clinical Center for Askin's Tumor

Genetic Tests for Askin's Tumor

Anatomical Context for Askin's Tumor

MalaCards organs/tissues related to Askin's Tumor:

41
Bone, Lung, Pancreas, T Cells, Myeloid, Liver, Breast

Publications for Askin's Tumor

Articles related to Askin's Tumor:

(show top 50) (show all 161)
# Title Authors PMID Year
1
Primary Intra-abdominal Ewing's Sarcoma in Adults: A Multimodality Imaging Spectrum. 38
30642618 2019
2
Surgical Treatment of Scoliosis Developed After Extended Chest Wall Resection Due to Askin Tumor During Childhood. 38
30587315 2019
3
Comparison of clinical features and outcomes in patients with extraskeletal vs skeletal Ewing sarcoma: an SEER database analysis of 3,178 cases. 38
30538569 2018
4
From Ataxia to Diagnosis of Askin Tumor - a Case Report. 38
30216185 2018
5
Askin's Tumor. A Rare Diagnosis in an Elderly Patient. 38
28499589 2017
6
Molecular cytogenetic characterization of two established ESFT cell lines. 38
27613543 2017
7
Askin tumor: A rare neoplasm of thoracopulmonary region. 38
27051109 2016
8
Bilateral Synchronus Askin's Tumor- Case Report & Review of Literature. 38
27065698 2016
9
Askin (PNET) Tumor Unmasked by Trauma in a Young Male Patient. 38
27731566 2016
10
Askin's tumor: 11 cases and a review of the literature. 38
26870198 2016
11
Multimodality Treatment in Ewing's Sarcoma Family Tumors of the Maxilla and Maxillary Sinus: Review of the Literature. 38
27413360 2016
12
Clinical features and outcomes of infants with Ewing sarcoma under 12 months of age. 38
26173989 2015
13
High-dose Thiotepa as Consolidation Therapy With Autologous Hematopoietic Stem Cell Transplantation for High-risk Ewing Family Tumors: Single-institution Experience. 38
26207773 2015
14
Locally Advanced Askin's Tumour in a Child-a Rare Case Report and Review of the Literature. 38
27217682 2015
15
A small Askin's tumor presenting with early onset of chest pain. 38
25884603 2015
16
Askin tumor: CT and FDG-PET/CT imaging findings and follow-up. 38
25058144 2014
17
Askin tumor mimicking a hydatid cyst of the lung in children: case report. 38
25374636 2014
18
[Rare observation of giant Askin's tumor with localization in anterior mediastinum]. 38
25823315 2014
19
Rapidly fatal Askin's tumor: a case report and literature review. 38
25404964 2014
20
[Long-term survival case of primitive neuroectodermal tumor in the chest wall of a young adult]. 38
24105117 2013
21
Treatment of an Askin tumor: A case report and review of the literature. 38
24137450 2013
22
Role of F18 fluorodeoxyglucose positron-emission tomography/computed tomography in the management of Askin's tumor. 38
24250031 2013
23
Primary primitive neuroectodermal tumor of the breast: a rare case presentation. 38
24426592 2013
24
Outcomes after interdisciplinary management of 7 patients with Askin tumor. 38
23397588 2013
25
From the radiologic pathology archives: ewing sarcoma family of tumors: radiologic-pathologic correlation. 38
23674776 2013
26
Askin's tumor: a case report and literature review. 38
23339634 2013
27
Suspected CNS Metastases of Askin's Tumor: Would You Irradiate the Neural Axis? 38
29147321 2012
28
EWS-FLI-1-targeted cytotoxic T-cell killing of multiple tumor types belonging to the Ewing sarcoma family of tumors. 38
22879388 2012
29
Nuclear scintigraphy findings for Askin tumor with In111-pentetreotide, Tc99m-MIBI and F18-FDG. 38
23378875 2012
30
Extraosseous Ewing's sarcoma of the pancreas. 38
21892669 2012
31
Congenital Askin tumor with favorable outcome: case report and review of the literature. 38
22813811 2012
32
Askin's Tumor with Massive Hemoptysis. 38
25191404 2012
33
Askin tumor: four case reports and a review of the literature. 38
22138531 2011
34
A Case of Askin's Tumor Presenting with Pleural Effusion and High Level of Adenosine Deaminase. 38
22110310 2011
35
Costovertebral rib disarticulation and pleurectomy in Askin's tumor: a mandatory approach to radical surgery in children? Case report and guiedelines to surgical treatment. 38
22519201 2011
36
Askin's Tumor: A Dual Case Study. 38
21792357 2011
37
Late surgery for spinal deformities in children previously treated for neural tumors. 38
21328191 2011
38
Complete clinical response to neoadjuvant chemotherapy in a 54-year-old male with Askin tumor. 38
20680911 2010
39
Epigenetic modifiers as anticancer drugs: effectiveness of valproic acid in neural crest-derived tumor cells. 38
20332466 2010
40
[Use of LAK-cells and systemic chemotherapy with hyperthermia in the management of chemo-resistant tumors]. 38
21395124 2010
41
[Askin tumor: a case report with literature review]. 38
19692278 2009
42
[Efficacy and survival of 92 cases of Ewing's sarcoma family of tumor initially treated with multidisciplinary therapy]. 38
19958626 2009
43
[Solution to case 9. Askin tumor]. 38
19800487 2009
44
Askin's tumor. 38
19634286 2009
45
Ewing's sarcoma: standard and experimental treatment options. 38
19533369 2009
46
Askin's Tumor in an Adult: Case Report and Findings on 18F-FDG PET/CT. 38
20049330 2009
47
Askin's tumor: a rare chest wall neoplasm. Case report and short review. 38
18615383 2008
48
Interaction between ERK and GSK3beta mediates basic fibroblast growth factor-induced apoptosis in SK-N-MC neuroblastoma cells. 38
18263590 2008
49
Ewing's sarcoma family of tumors: an overview from diagnosis to survivorship. 38
18258578 2008
50
Emerging chemotherapeutic strategies and the role of treatment stratification in Ewing sarcoma. 38
18345719 2008

Variations for Askin's Tumor

Expression for Askin's Tumor

Search GEO for disease gene expression data for Askin's Tumor.

Pathways for Askin's Tumor

Pathways related to Askin's Tumor according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.4 NTRK1 NGF MYC
2 12.35 NTRK1 NGF MYC
3 11.99 NTRK1 NGF MYCN ENO2
4
Show member pathways
11.79 NTRK1 NGF MYC
5
Show member pathways
11.68 NTRK1 NGF MYC
6
Show member pathways
11.39 NTRK1 NGF
7 11.3 MYCN MYC
8 11.3 NTRK1 MYC
9
Show member pathways
11.22 NTRK1 NGF
10 11.19 NTRK1 MYCN MYC EWSR1
11 11.02 NTRK1 NGF
12
Show member pathways
10.3 NTRK1 NGF
13 9.65 MYCN MYC

GO Terms for Askin's Tumor

Biological processes related to Askin's Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.58 NGF MYCN MYC
2 activation of MAPKK activity GO:0000186 9.37 NTRK1 NGF
3 phosphatidylinositol-mediated signaling GO:0048015 9.32 NTRK1 NGF
4 positive regulation of DNA binding GO:0043388 9.26 NGF MYC
5 positive regulation of Ras protein signal transduction GO:0046579 9.16 NTRK1 NGF
6 neurotrophin TRK receptor signaling pathway GO:0048011 8.96 NTRK1 NGF
7 nerve growth factor signaling pathway GO:0038180 8.62 NTRK1 NGF

Sources for Askin's Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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