Aliases & Classifications for Askin's Tumor

MalaCards integrated aliases for Askin's Tumor:

Name: Askin's Tumor 12 15 71
Askin Tumor 12 17
Askin's Tumour 12
Askin Tumour 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050608
UMLS 71 C0877849

Summaries for Askin's Tumor

Disease Ontology : 12 An Ewing sarcoma that arises from the soft tissues of the chest wall that tend to recur locally and not widely disseminated.

MalaCards based summary : Askin's Tumor, also known as askin tumor, is related to spindle cell sarcoma and clear cell sarcoma, and has symptoms including fever An important gene associated with Askin's Tumor is ENO2 (Enolase 2), and among its related pathways/superpathways is Transcriptional misregulation in cancer. The drugs Insulin, Globin Zinc and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include pancreas, myeloid and liver, and related phenotype is nervous system.

Related Diseases for Askin's Tumor

Diseases related to Askin's Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 182)
# Related Disease Score Top Affiliating Genes
1 spindle cell sarcoma 30.0 MYOG EWSR1 CCNB3
2 clear cell sarcoma 29.9 SYP EWSR1 ENO2 CCNB3
3 ewing sarcoma 29.2 SYP NKX2-2 MYOG IGF1R FLII FLI1
4 sarcoma 29.2 PATZ1 MYOG FLI1 EWSR1 ETV1
5 rare tumor 10.4
6 extraskeletal mesenchymal chondrosarcoma 10.4 EWSR1 CD99
7 retroperitoneal neuroblastoma 10.4 ENO2 CD99
8 extraskeletal ewing sarcoma 10.3 FLI1 EWSR1
9 malignant melanocytic neoplasm of the peripheral nerve sheath 10.3 SYP ENO2
10 anal neuroendocrine tumor 10.3 SYP ENO2
11 optic nerve astrocytoma 10.3 SYP ENO2
12 cerebral neuroblastoma 10.3 SYP ENO2
13 neuronal intestinal dysplasia, type b 10.3 SYP ENO2
14 lung meningioma 10.3 SYP ENO2
15 sinonasal undifferentiated carcinoma 10.3 SYP ENO2
16 auditory system benign neoplasm 10.3 SYP ENO2
17 papillary tumor of the pineal region 10.3 SYP ENO2
18 small cell carcinoma of the bladder 10.3 SYP ENO2
19 auditory system cancer 10.3 SYP ENO2
20 cloacogenic carcinoma 10.3 SYP ENO2
21 bile duct mucinous adenocarcinoma 10.3 SYP ENO2
22 nodular prostate 10.3 SYP ENO2
23 ampulla of vater neoplasm 10.3 SYP ENO2
24 appendix carcinoid tumor 10.3 SYP ENO2
25 carotid body cancer 10.3 SYP ENO2
26 gallbladder small cell carcinoma 10.3 SYP ENO2
27 ureter small cell carcinoma 10.3 SYP ENO2
28 cerebellar liponeurocytoma 10.3 SYP ENO2
29 middle ear adenoma 10.3 SYP ENO2
30 urinary bladder small cell neuroendocrine carcinoma 10.3 SYP ENO2
31 gastric small cell carcinoma 10.3 SYP ENO2
32 jejunal neoplasm 10.3 SYP ENO2
33 frontal lobe neoplasm 10.3 SYP ENO2
34 sensory organ benign neoplasm 10.3 SYP ENO2
35 ovarian large-cell neuroendocrine carcinoma 10.3 SYP ENO2
36 gastric hemangioma 10.3 SYP ENO2
37 subependymoma 10.3 SYP ENO2
38 kidney fibrosarcoma 10.3 EWSR1 CD99
39 pineocytoma 10.3 SYP ENO2
40 pineal parenchymal tumor of intermediate differentiation 10.3 SYP ENO2
41 cutaneous ganglioneuroma 10.3 SYP ENO2
42 spinal cord oligodendroglioma 10.3 SYP ENO2
43 cervix small cell carcinoma 10.3 SYP ENO2
44 adrenal neuroblastoma 10.3 SYP ENO2
45 orbital cancer 10.3 SYP ENO2
46 gastrointestinal neuroendocrine tumor 10.3 SYP ENO2
47 carcinoid tumors, intestinal 10.3 SYP ENO2
48 endometrial small cell carcinoma 10.3 SYP ENO2
49 colon neuroendocrine neoplasm 10.3 SYP ENO2
50 carcinoid syndrome 10.3 SYP ENO2

Graphical network of the top 20 diseases related to Askin's Tumor:



Diseases related to Askin's Tumor

Symptoms & Phenotypes for Askin's Tumor

UMLS symptoms related to Askin's Tumor:


fever

MGI Mouse Phenotypes related to Askin's Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.28 ENO2 ETV1 ETV4 FLI1 FLII IGF1R

Drugs & Therapeutics for Askin's Tumor

Drugs for Askin's Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Insulin, Globin Zinc Phase 2
2 Immunoglobulins Phase 2
3 Mitogens Phase 2
4 Antibodies, Monoclonal Phase 2
5 Antibodies Phase 2
6 insulin Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Study of AMG 479 in Relapsed or Refractory Ewing's Family Tumor and Desmoplastic Small Round Cell Tumors Completed NCT00563680 Phase 2 AMG 479
2 Phase I Trial of Pbi-shRNAâ„¢ EWS/FLI1 Type 1 Lipoplex (LPX) in Subjects With Advanced Ewing's Sarcoma Active, not recruiting NCT02736565 Phase 1
3 A COG Study for Collecting and Banking Ewing Sarcoma Specimens Active, not recruiting NCT00899990

Search NIH Clinical Center for Askin's Tumor

Genetic Tests for Askin's Tumor

Anatomical Context for Askin's Tumor

MalaCards organs/tissues related to Askin's Tumor:

40
Pancreas, Myeloid, Liver, Breast, Uterus, Prostate

Publications for Askin's Tumor

Articles related to Askin's Tumor:

(show top 50) (show all 165)
# Title Authors PMID Year
1
Thoracoscopic (hybrid) complex chest wall resection in pediatric Ewing sarcoma. 61
33143433 2021
2
Askin tumor in the chest wall. 61
33325129 2021
3
Askin tumor with clivus metastasis: An uncommon location. 61
33162221 2020
4
Rosettes-Diagnostic Feature of Askin Tumor on Cytology. 61
33013126 2020
5
Primary Intra-abdominal Ewing's Sarcoma in Adults: A Multimodality Imaging Spectrum. 61
30642618 2020
6
Askin's tumor in an elderly patient. 61
31490006 2019
7
Surgical Treatment of Scoliosis Developed After Extended Chest Wall Resection Due to Askin Tumor During Childhood. 61
30587315 2019
8
Comparison of clinical features and outcomes in patients with extraskeletal vs skeletal Ewing sarcoma: an SEER database analysis of 3,178 cases. 61
30538569 2018
9
From Ataxia to Diagnosis of Askin Tumor - a Case Report. 61
30216185 2018
10
An unusual biconvex epidural lesion: acutely presenting extraosseous intracranial Ewing's sarcoma. 61
32922892 2018
11
Askin's Tumor. A Rare Diagnosis in an Elderly Patient. 61
28499589 2017
12
Molecular cytogenetic characterization of two established ESFT cell lines. 61
27613543 2017
13
Bilateral Synchronus Askin's Tumor- Case Report & Review of Literature. 61
27065698 2016
14
Askin tumor: A rare neoplasm of thoracopulmonary region. 61
27051109 2016
15
Askin (PNET) Tumor Unmasked by Trauma in a Young Male Patient. 61
27731566 2016
16
Askin's tumor: 11 cases and a review of the literature. 61
26870198 2016
17
Multimodality Treatment in Ewing's Sarcoma Family Tumors of the Maxilla and Maxillary Sinus: Review of the Literature. 61
27413360 2016
18
Clinical features and outcomes of infants with Ewing sarcoma under 12 months of age. 61
26173989 2015
19
High-dose Thiotepa as Consolidation Therapy With Autologous Hematopoietic Stem Cell Transplantation for High-risk Ewing Family Tumors: Single-institution Experience. 61
26207773 2015
20
Locally Advanced Askin's Tumour in a Child-a Rare Case Report and Review of the Literature. 61
27217682 2015
21
A small Askin's tumor presenting with early onset of chest pain. 61
25884603 2015
22
Askin tumor: CT and FDG-PET/CT imaging findings and follow-up. 61
25058144 2014
23
Rapidly fatal Askin's tumor: a case report and literature review. 61
25404964 2014
24
Askin tumor mimicking a hydatid cyst of the lung in children: case report. 61
25374636 2014
25
[Rare observation of giant Askin's tumor with localization in anterior mediastinum]. 61
25823315 2014
26
[Long-term survival case of primitive neuroectodermal tumor in the chest wall of a young adult]. 61
24105117 2013
27
Treatment of an Askin tumor: A case report and review of the literature. 61
24137450 2013
28
Role of F18 fluorodeoxyglucose positron-emission tomography/computed tomography in the management of Askin's tumor. 61
24250031 2013
29
Primary primitive neuroectodermal tumor of the breast: a rare case presentation. 61
24426592 2013
30
Outcomes after interdisciplinary management of 7 patients with Askin tumor. 61
23397588 2013
31
From the radiologic pathology archives: ewing sarcoma family of tumors: radiologic-pathologic correlation. 61
23674776 2013
32
Askin's tumor: a case report and literature review. 61
23339634 2013
33
Suspected CNS Metastases of Askin's Tumor: Would You Irradiate the Neural Axis? 61
29147321 2012
34
Nuclear scintigraphy findings for Askin tumor with In111-pentetreotide, Tc99m-MIBI and F18-FDG. 61
23378875 2012
35
EWS-FLI-1-targeted cytotoxic T-cell killing of multiple tumor types belonging to the Ewing sarcoma family of tumors. 61
22879388 2012
36
Extraosseous Ewing's sarcoma of the pancreas. 61
21892669 2012
37
Congenital Askin tumor with favorable outcome: case report and review of the literature. 61
22813811 2012
38
Askin's Tumor with Massive Hemoptysis. 61
25191404 2012
39
Askin tumor: four case reports and a review of the literature. 61
22138531 2011
40
A Case of Askin's Tumor Presenting with Pleural Effusion and High Level of Adenosine Deaminase. 61
22110310 2011
41
Costovertebral rib disarticulation and pleurectomy in Askin's tumor: a mandatory approach to radical surgery in children? Case report and guiedelines to surgical treatment. 61
22519201 2011
42
Askin's Tumor: A Dual Case Study. 61
21792357 2011
43
Late surgery for spinal deformities in children previously treated for neural tumors. 61
21328191 2011
44
Complete clinical response to neoadjuvant chemotherapy in a 54-year-old male with Askin tumor. 61
20680911 2010
45
Epigenetic modifiers as anticancer drugs: effectiveness of valproic acid in neural crest-derived tumor cells. 61
20332466 2010
46
[Use of LAK-cells and systemic chemotherapy with hyperthermia in the management of chemo-resistant tumors]. 61
21395124 2010
47
[Efficacy and survival of 92 cases of Ewing's sarcoma family of tumor initially treated with multidisciplinary therapy]. 61
19958626 2009
48
[Askin tumor: a case report with literature review]. 61
19692278 2009
49
[Solution to case 9. Askin tumor]. 61
19800487 2009
50
Askin's tumor. 61
19634286 2009

Variations for Askin's Tumor

Expression for Askin's Tumor

Search GEO for disease gene expression data for Askin's Tumor.

Pathways for Askin's Tumor

Pathways related to Askin's Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.3 IGF1R FLI1 EWSR1 ETV4 ETV1

GO Terms for Askin's Tumor

Biological processes related to Askin's Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.17 PATZ1 NKX2-2 MYOG FLI1 EWSR1 ETV4

Molecular functions related to Askin's Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.73 PATZ1 NKX2-2 MYOG FLI1 ETV4 ETV1
2 DNA-binding transcription factor activity GO:0003700 9.55 NKX2-2 MYOG FLI1 ETV4 ETV1
3 sequence-specific DNA binding GO:0043565 9.35 NKX2-2 MYOG FLI1 ETV4 ETV1
4 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.02 NKX2-2 MYOG FLI1 ETV4 ETV1

Sources for Askin's Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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