MCID: ASK001
MIFTS: 35

Askin's Tumor

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Askin's Tumor

MalaCards integrated aliases for Askin's Tumor:

Name: Askin's Tumor 12 15 71
Askin's Tumour 12
Askin Tumour 12
Askin Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050608
UMLS 71 C0877849

Summaries for Askin's Tumor

Disease Ontology : 12 An Ewing sarcoma that arises from the soft tissues of the chest wall that tend to recur locally and not widely disseminated.

MalaCards based summary : Askin's Tumor, also known as askin's tumour, is related to clear cell sarcoma and neuroblastoma, and has symptoms including fever An important gene associated with Askin's Tumor is ENO2 (Enolase 2), and among its related pathways/superpathways are Neuroscience and NGF Pathway. The drugs Vincristine and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include bone, pancreas and liver, and related phenotypes are muscle and nervous system

Related Diseases for Askin's Tumor

Diseases related to Askin's Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)
# Related Disease Score Top Affiliating Genes
1 clear cell sarcoma 29.5 SYP EWSR1 ENO2 CCNB3
2 neuroblastoma 29.1 SYP PTK2 NTRK1 NGF MYCN MYC
3 ewing sarcoma 28.7 SYP PTK2 MYCN MYC FLII FLI1
4 rare tumor 10.6
5 nodular ganglioneuroblastoma 10.5 MYCN ENO2
6 multiple mucosal neuroma 10.5 NTRK1 ENO2
7 appendix lymphoma 10.4 MYC ENO2
8 neurogenic arthropathy 10.4 NTRK1 NGF
9 ectomesenchymoma 10.4 ENO2 CD99
10 extraskeletal mesenchymal chondrosarcoma 10.4 EWSR1 CD99
11 retroperitoneal neuroblastoma 10.3 MYCN ENO2 CD99
12 neuropathy, hereditary sensory and autonomic, type v 10.3 NTRK1 NGF
13 embryonal rhabdomyosarcoma 10.2 MYCN MYC EWSR1
14 ocular cicatricial pemphigoid 10.2 NTRK1 NGF
15 scoliosis 10.2
16 malignant melanocytic neoplasm of the peripheral nerve sheath 10.2 SYP ENO2
17 anal neuroendocrine tumor 10.2 SYP ENO2
18 breast neuroendocrine neoplasm 10.2 SYP ENO2
19 sinonasal undifferentiated carcinoma 10.2 SYP ENO2
20 papillary tumor of the pineal region 10.2 SYP ENO2
21 small cell carcinoma of the bladder 10.2 SYP ENO2
22 desmoplastic infantile ganglioglioma 10.2 SYP MYCN
23 sweat gland disease 10.2 NTRK1 NGF EWSR1
24 pineal region teratoma 10.2 SYP ENO2
25 bile duct mucinous adenocarcinoma 10.2 SYP ENO2
26 auditory system benign neoplasm 10.2 SYP ENO2
27 appendix carcinoid tumor 10.2 SYP ENO2
28 central nervous system mesenchymal non-meningothelial tumor 10.2 EWSR1 ENO2 CD99
29 auditory system cancer 10.2 SYP ENO2
30 duodenal benign neoplasm 10.2 SYP ENO2
31 nodular prostate 10.2 SYP ENO2
32 ossifying fibromyxoid tumor 10.2 ENO2 CCNB3
33 ampulla of vater neoplasm 10.2 SYP ENO2
34 urinary bladder small cell neuroendocrine carcinoma 10.2 SYP ENO2
35 ureter small cell carcinoma 10.2 SYP ENO2
36 small cell sarcoma 10.2 EWSR1 CCNB3
37 cerebellar liponeurocytoma 10.2 SYP ENO2
38 papillary ependymoma 10.2 SYP ENO2
39 middle ear adenoma 10.2 SYP ENO2
40 jejunal neoplasm 10.2 SYP ENO2
41 carotid body cancer 10.2 SYP ENO2
42 gallbladder small cell carcinoma 10.2 SYP ENO2
43 vulva basal cell carcinoma 10.2 SYP MYC
44 gastric small cell carcinoma 10.2 SYP ENO2
45 sensory organ benign neoplasm 10.2 SYP ENO2
46 subependymoma 10.2 SYP ENO2
47 pineocytoma 10.2 SYP ENO2
48 myoblastoma 10.2 SYP ENO2
49 pineal parenchymal tumor of intermediate differentiation 10.2 SYP ENO2
50 optic nerve astrocytoma 10.2 SYP ENO2

Graphical network of the top 20 diseases related to Askin's Tumor:



Diseases related to Askin's Tumor

Symptoms & Phenotypes for Askin's Tumor

UMLS symptoms related to Askin's Tumor:


fever

MGI Mouse Phenotypes related to Askin's Tumor:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.76 ETV1 ETV4 FLI1 MYC MYCN NGF
2 nervous system MP:0003631 9.65 ENO2 ETV1 ETV4 FLI1 MYC MYCN
3 normal MP:0002873 9.17 ETV1 MYC MYCN NGF NTRK1 PTK2

Drugs & Therapeutics for Askin's Tumor

Drugs for Askin's Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 2 57-22-7, 2068-78-2 5978
2
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
3
Ifosfamide Approved Phase 2 3778-73-2 3690
4
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
5
Etoposide Approved Phase 2 33419-42-0 36462
6 Antibiotics, Antitubercular Phase 2
7 Immunologic Factors Phase 2
8 Etoposide phosphate Phase 2
9
Liposomal doxorubicin Phase 2 31703
10 Immunosuppressive Agents Phase 2
11 Alkylating Agents Phase 2
12
Isophosphamide mustard Phase 2 0
13 Tubulin Modulators Phase 2
14 Antirheumatic Agents Phase 2
15 Antimitotic Agents Phase 2
16 Anti-Bacterial Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study of Cyclophosphamide, Doxorubicin, Vincristine, Etoposide, and Ifosfamide, Followed by Resection and Radiotherapy in Patients With Peripheral Primitive Neuroectodermal Tumors or Ewing's Sarcoma Completed NCT00002466 Phase 2 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
2 Phase I Trial of Pbi-shRNA™ EWS/FLI1 Type 1 Lipoplex (LPX) in Subjects With Advanced Ewing's Sarcoma Active, not recruiting NCT02736565 Phase 1
3 Patterns of Care and Outcomes of Patients With METAstatic BONE Tumors in a Real-life Setting Recruiting NCT03963531
4 A COG Study for Collecting and Banking Ewing Sarcoma Specimens Active, not recruiting NCT00899990

Search NIH Clinical Center for Askin's Tumor

Genetic Tests for Askin's Tumor

Anatomical Context for Askin's Tumor

MalaCards organs/tissues related to Askin's Tumor:

40
Bone, Pancreas, Liver, Prostate, Testes, T Cells

Publications for Askin's Tumor

Articles related to Askin's Tumor:

(show top 50) (show all 81)
# Title Authors PMID Year
1
Primary Intra-abdominal Ewing's Sarcoma in Adults: A Multimodality Imaging Spectrum. 61
30642618 2020
2
Askin's tumor in an elderly patient. 61
31490006 2019
3
Askin's Tumor. A Rare Diagnosis in an Elderly Patient. 61
28499589 2017
4
Molecular cytogenetic characterization of two established ESFT cell lines. 61
27613543 2017
5
Askin's tumour in pregnancy with dismal prognosis. 61
25354014 2016
6
Bilateral Synchronus Askin's Tumor- Case Report & Review of Literature. 61
27065698 2016
7
Askin's tumor: 11 cases and a review of the literature. 61
26870198 2016
8
Multimodality Treatment in Ewing's Sarcoma Family Tumors of the Maxilla and Maxillary Sinus: Review of the Literature. 61
27413360 2016
9
Locally Advanced Askin's Tumour in a Child-a Rare Case Report and Review of the Literature. 61
27217682 2015
10
A small Askin's tumor presenting with early onset of chest pain. 61
25884603 2015
11
Rapidly fatal Askin's tumor: a case report and literature review. 61
25404964 2014
12
[Rare observation of giant Askin's tumor with localization in anterior mediastinum]. 61
25823315 2014
13
[Long-term survival case of primitive neuroectodermal tumor in the chest wall of a young adult]. 61
24105117 2013
14
Role of F18 fluorodeoxyglucose positron-emission tomography/computed tomography in the management of Askin's tumor. 61
24250031 2013
15
Askin's Tumour in an Adult, with a Varied Clinical Presentation. 61
23543843 2013
16
Askin's tumor: a case report and literature review. 61
23339634 2013
17
Suspected CNS Metastases of Askin's Tumor: Would You Irradiate the Neural Axis? 61
29147321 2012
18
EWS-FLI-1-targeted cytotoxic T-cell killing of multiple tumor types belonging to the Ewing sarcoma family of tumors. 61
22879388 2012
19
Extraosseous Ewing's sarcoma of the pancreas. 61
21892669 2012
20
Askin's Tumor with Massive Hemoptysis. 61
25191404 2012
21
A Case of Askin's Tumor Presenting with Pleural Effusion and High Level of Adenosine Deaminase. 61
22110310 2011
22
Costovertebral rib disarticulation and pleurectomy in Askin's tumor: a mandatory approach to radical surgery in children? Case report and guiedelines to surgical treatment. 61
22519201 2011
23
Askin's Tumor: A Dual Case Study. 61
21792357 2011
24
[Use of LAK-cells and systemic chemotherapy with hyperthermia in the management of chemo-resistant tumors]. 61
21395124 2010
25
Askin's tumor. 61
19634286 2009
26
Askin's Tumor in an Adult: Case Report and Findings on 18F-FDG PET/CT. 61
20049330 2009
27
Askin's tumor: a rare chest wall neoplasm. Case report and short review. 61
18615383 2008
28
Interaction between ERK and GSK3beta mediates basic fibroblast growth factor-induced apoptosis in SK-N-MC neuroblastoma cells. 61
18263590 2008
29
Treatment planning comparison of electron arc therapy and photon intensity modulated radiotherapy for Askin's tumor of chest wall. 61
17719111 2007
30
Primitive neuroectodermal tumor of the sternum in a child: resection and reconstruction. 61
17101344 2006
31
The results of surgical treatment of chest wall tumors in childhood. 61
16328338 2006
32
How to treat the Ewing's family of sarcomas in adult patients. 61
16401715 2006
33
Ewing's sarcoma and primitive neuroectodermal family of tumors. 61
15939194 2005
34
A primitive neuroectodermal tumor on the face: case report. 61
16033149 2005
35
[Askin's tumor with sigmoid metastasis]. 61
15180448 2004
36
Diagnostic significance and clinical applications of chimeric genes in Ewing's sarcoma. 61
12736494 2003
37
[Askin's tumour]. 61
12632573 2003
38
Peripheral primitive neuroectodermal tumour (pPNET) of the cerebellopontine angle presenting in adult life. 61
11668007 2001
39
[Askin's tumor of the chest wall with early metastasis]. 61
11412509 2001
40
Peripheral primitive neuroectodermal tumor (PPNET) of pelvic origin: report of a case arising from an unusual location. 61
11401207 2001
41
Successful use of intraoperative radiotherapy for local control of an Askin's tumor recurrence. 61
11292924 2001
42
Neurogenic tumours of the mediastinum: a report of 60 cases. 61
10903489 2000
43
Malignant chest wall tumors in children and young adults. 61
10626852 1999
44
[Askin's tumor--a rare entity. Case report with references to the literature]. 61
10483278 1999
45
[Spinal primitive neuroectodermal tumor]. 61
10327753 1999
46
[Askin's+ tumor in childhood. Considerations after a 2-year follow-up]. 61
9656068 1998
47
Surgical treatment of primary malignant chest wall tumours. 61
9237580 1997
48
Histology, immunohistochemistry, and electron microscopy of small round cell tumors of bone. 61
8875707 1996
49
Usefulness of cytogenetic analysis in the diagnosis of undifferentiated synovial sarcoma of the chest wall. A case report. 61
7496742 1995
50
Immunohistology, cytogenetics, and molecular studies of small round cell tumors of childhood. A review. 61
7762971 1995

Variations for Askin's Tumor

Expression for Askin's Tumor

Search GEO for disease gene expression data for Askin's Tumor.

Pathways for Askin's Tumor

Pathways related to Askin's Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.89 SYP NTRK1 NGF MYCN ENO2
2
Show member pathways
11.68 NTRK1 NGF MYC
3 11.51 PTK2 NTRK1 MYCN MYC FLI1 EWSR1
4
Show member pathways
10.3 NTRK1 NGF
5 9.85 MYCN MYC

GO Terms for Askin's Tumor

Cellular components related to Askin's Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 host cell nucleus GO:0042025 8.92 MYCN MYC FLI1 CCNB3

Biological processes related to Askin's Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 9.65 MYCN MYC FLI1 ETV4 ETV1
2 neurotrophin TRK receptor signaling pathway GO:0048011 9.16 NTRK1 NGF
3 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.13 PTK2 NTRK1 NGF
4 nerve growth factor signaling pathway GO:0038180 8.62 NTRK1 NGF

Molecular functions related to Askin's Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10 TSFM PTK2 NTRK1 NGF MYCN MYC
2 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.35 MYCN MYC FLI1 ETV4 ETV1
3 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.02 MYCN MYC FLI1 ETV4 ETV1

Sources for Askin's Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....