MCID: ASP001
MIFTS: 48

Asperger Syndrome

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Asperger Syndrome

MalaCards integrated aliases for Asperger Syndrome:

Name: Asperger Syndrome 12 73 20 53 36 54 44 15 17 70 32
Asperger's Disease 29
Asperger Disorder 20

Classifications:



External Ids:

Disease Ontology 12 DOID:0050432
KEGG 36 H01882
MeSH 44 D020817
NCIt 50 C97159
SNOMED-CT 67 154879004
ICD10 32 F84.5
UMLS 70 C0236792

Summaries for Asperger Syndrome

GARD : 20 Asperger syndrome is part of the autism spectrum disorder (ASD), a group of disorders that affects the development of social and communication skills. Unlike many children with ASD, children with Asperger syndrome do not have early language delays, and often have well developed language skills and normal to above average intelligence. However, they may use unusual speech patterns and have a hard time understanding irony, humor, and sarcasm or gestures and social cues important to normal conversation. Many children with Asperger syndrome develop an obsessive interest in one topic or object. They may use high-level vocabulary or complex statistics in conversation. Children with Asperger syndrome may have delayed motor skills and thus can appear uncoordinated and clumsy compared to their peers. Other features of Asperger syndrome include difficulty interacting with peers, inappropriate social or emotional behavior, and engaging in repetitive routines. Both children and adults with Asperger syndrome are at an increased risk for depression, attention deficit hyperactivity disorder (ADHD), mood and anxiety disorders, and other mental health disorders. The cause of Asperger syndrome, like most ASDs, is not fully understood, but there is a strong genetic basis, which means it does tend to run in families. Multiple environmental factors are also thought to play an important role in the development of all ASDs. Treatment for Asperger syndrome depends on each person's age and needs, and the recommendation is for treatment to begin as early as possible. Many people with Asperger syndrome can learn strategies to manage their symptoms. Treatment may include behavioral therapy, speech and language therapy, support in school, and mental health counseling. Medications may sometimes be used for behavioral or mood disorders. Of note: the newest edition, updated in 2013, of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V), which is used predominantly in the United States (US), replaced the terms Asperger syndrome and other pervasive developmental disorders with the umbrella diagnosis of autism spectrum disorder. This means that currently, Asperger syndrome is not officially considered a separate disorder in US, but instead it is now part of the autism spectrum disorder (ASD). However, many doctors still use this term. The World Health Organization International Classification of Diseases, (ICD-11) which is used in other countries throughout the world still uses Asperger syndrome as a subtype of ASD.

MalaCards based summary : Asperger Syndrome, also known as asperger's disease, is related to autism spectrum disorder and autism. An important gene associated with Asperger Syndrome is ASPG2 (Asperger Syndrome, Susceptibility To, 2), and among its related pathways/superpathways are Cell adhesion molecules and Transmission across Chemical Synapses. The drugs Risperidone and Milnacipran have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and amygdala, and related phenotypes are behavior/neurological and growth/size/body region

Disease Ontology : 12 An autism spectrum disorder that is characterized by significant difficulties in social interaction, along with restricted and repetitive patterns of behavior and interests. It differs from other autism spectrum disorders by its relative preservation of linguistic and cognitive development.

NINDS : 53 Asperger syndrome (AS) is a developmental disorder.  It is an autism spectrum disorder (ASD), one of a distinct group of neurological conditions characterized by a greater or lesser degree of impairment in language and communication skills, as well as repetitive or restrictive patterns of thought and behavior.  Other ASDs include:  classic autism, Rett syndrome, childhood disintegrative disorder, and pervasive developmental disorder not otherwise specified (usually referred to as PDD-NOS). Unlike children with autism, children with AS retain their early language skills. The most distinguishing symptom of AS is a child’s obsessive interest in a single object or topic to the exclusion of any other.  Children with AS want to know everything about their topic of interest and their conversations with others will be about little else.  Their expertise, high level of vocabulary, and formal speech patterns make them seem like little professors.  Other characteristics of AS include repetitive routines or rituals; peculiarities in speech and language; socially and emotionally inappropriate behavior and the inability to interact successfully with peers; problems with non-verbal communication; and clumsy and uncoordinated motor movements. Children with AS are isolated because of their poor social skills and narrow interests.  They may approach other people, but make normal conversation impossible by inappropriate or eccentric behavior, or by wanting only to talk about their singular interest.    Children with AS usually have a history of developmental delays in motor skills such as pedaling a bike, catching a ball, or climbing outdoor play equipment.   They are often awkward and poorly coordinated with a walk that can appear either stilted or bouncy.

KEGG : 36 Asperger syndrome (AS), a behavioral disorder that is related to autism, is associated with abnormal social functioning and repetitive behaviors but not with a decrease in intelligence or linguistic functionality. AS may be present with several comorbid disorders including attention deficit hyperactivity disorder, anxiety, schizophrenia, bipolar disorder, depression, and Tourette syndrome. The standard pharmacotherapies typically administered to other comorbid disorders are also prescribed to AS patients. Although medication therapy may be beneficial in stabilizing AS patients, it does not cure the disorder. Cognitive behavioural therapy (CBT) may be an effective behavioral approach to implement, and it may also reduce the number of pharmacotherapies necessary for AS patients. Although medication therapy may be beneficial in stabilizing AS patients, it does not cure the disorder. Cognitive behavioural therapy (CBT) may be an effective behavioral approach to implement, and it may also reduce the number of pharmacotherapies necessary for AS patients. The pathophysiology of AS remains unclear and the causes of AS are not known. The male-to-female ratio is 8:1 in AS. Genetic factors appear to play a role in AS because of their tendency to run in families and the high concordance in twins. However, a specific gene for AS has not been identified. Recent studies have suggested that the mutations in two X-linked genes, neuroligins NLGN3 and NLGN4 are associated with autism and AS.

Wikipedia : 73 Asperger syndrome (AS), also known as Asperger's, is a neurodevelopmental disorder characterized by... more...

Related Diseases for Asperger Syndrome

Diseases in the Asperger Syndrome family:

Asperger Syndrome 2 Asperger Syndrome 1
Asperger Syndrome 3 Asperger Syndrome 4

Diseases related to Asperger Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 autism spectrum disorder 31.8 SLC6A4 SLC25A12 OXTR OXT NLGN4X NLGN3
2 autism 31.6 SLC6A4 SLC25A12 OXTR OXT NLGN4X NLGN3
3 pervasive developmental disorder 31.4 SLC6A4 OXTR OXT NLGN4X NLGN3 NLGN1
4 obsessive-compulsive disorder 30.9 SLC6A4 OXTR OXT BDNF
5 prosopagnosia 30.8 OXTR OXT
6 anxiety 30.8 SLC6A4 OXTR OXT DISC1 BDNF AVPR1B
7 attention deficit-hyperactivity disorder 30.7 SLC6A4 OXT NLGN4X MECP2 BDNF AVPR1B
8 psychotic disorder 30.7 SLC6A4 OXT GABRB3 DISC1 BDNF
9 personality disorder 30.6 SLC6A4 OXTR BDNF AVPR1A
10 alexithymia 30.6 SLC6A4 OXTR OXT
11 gilles de la tourette syndrome 30.6 SLC6A4 NLGN4X BDNF
12 atypical autism 30.5 OXTR OXT NLGN4X NLGN3 MECP2 GABRB3
13 social phobia 30.5 SLC6A4 OXT BDNF
14 eating disorder 30.4 SLC6A4 OXTR BDNF
15 tic disorder 30.3 SLC6A4 NLGN4X NLGN3
16 schizophrenia 30.3 SLC6A4 OXTR OXT NLGN4X NLGN1 MECP2
17 acute stress disorder 30.3 SLC6A4 OXT BDNF
18 oppositional defiant disorder 30.3 SLC6A4 OXTR OXT
19 endogenous depression 30.2 SLC6A4 OXTR OXT BDNF
20 anorexia nervosa 30.2 SLC6A4 OXT BDNF
21 borderline personality disorder 30.2 SLC6A4 OXTR BDNF AVPR1A
22 mental depression 30.2 SLC6A4 OXTR OXT DISC1 BDNF
23 post-traumatic stress disorder 30.1 SLC6A4 OXTR NLGN1 GABRB3 BDNF
24 prader-willi syndrome 30.1 OXT MECP2 GABRG3 GABRB3 BDNF
25 major depressive disorder 30.1 SLC6A4 OXTR OXT DISC1 BDNF AVPR1B
26 bipolar disorder 29.8 SLC6A4 MECP2 GABRB3 DISC1 BDNF AVPR1A
27 speech and communication disorders 29.6 OXT MECP2 BDNF
28 asperger syndrome, x-linked 1 11.8
29 asperger syndrome, x-linked 2 11.7
30 asperger syndrome 2 11.7
31 asperger syndrome 3 11.7
32 asperger syndrome 1 11.6
33 asperger syndrome 4 11.6
34 autism 7 11.1
35 autism x-linked 1 11.1
36 autism x-linked 2 11.1
37 autism x-linked 3 11.1
38 autism x-linked 4 11.1
39 autism x-linked 5 11.1
40 autism x-linked 6 11.1
41 autism 8 11.1
42 autism 3 11.1
43 autism 6 11.1
44 autism 11 11.1
45 autism 12 11.1
46 autism 13 11.1
47 autism 9 11.1
48 autism 10 11.1
49 autism 15 11.1
50 autism 16 11.1

Graphical network of the top 20 diseases related to Asperger Syndrome:



Diseases related to Asperger Syndrome

Symptoms & Phenotypes for Asperger Syndrome

MGI Mouse Phenotypes related to Asperger Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.17 ARNT2 AVPR1A AVPR1B BDNF CYP11B1 DISC1
2 growth/size/body region MP:0005378 9.97 ARNT2 BDNF CYP11B1 DISC1 GABRB3 GABRG3
3 endocrine/exocrine gland MP:0005379 9.91 ARNT2 AVPR1A AVPR1B BDNF CYP11B1 MECP2
4 nervous system MP:0003631 9.77 ARNT2 AVPR1A AVPR1B BDNF DISC1 GABRB3
5 normal MP:0002873 9.23 AVPR1A BDNF GABRB3 MECP2 NLGN1 NLGN3

Drugs & Therapeutics for Asperger Syndrome

Drugs for Asperger Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
2
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
3
Levomilnacipran Approved, Investigational Phase 4 96847-54-0
4
Norepinephrine Approved Phase 4 51-41-2 439260
5
Choline Approved, Nutraceutical Phase 4 62-49-7 305
6
Creatine Approved, Investigational, Nutraceutical Phase 4 57-00-1 586
7 Immunologic Factors Phase 4
8 Rho(D) Immune Globulin Phase 4
9 Immunoglobulins Phase 4
10 Immunoglobulins, Intravenous Phase 4
11 Antibodies Phase 4
12 gamma-Globulins Phase 4
13 Neurotransmitter Agents Phase 4
14 Psychotropic Drugs Phase 4
15 Dopamine Antagonists Phase 4
16 Antipsychotic Agents Phase 4
17 Antidepressive Agents Phase 4
18 Atomoxetine Hydrochloride Phase 4
19 Adrenergic Agents Phase 4
20 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
21 Analgesics Phase 4
22 Analgesics, Non-Narcotic Phase 4
23
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
24
Phosphocreatine Nutraceutical Phase 4 67-07-2 587
25
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
26
Cycloserine Approved Phase 3 68-41-7 401 6234
27 Dopamine Agents Phase 3
28 Antimetabolites Phase 3
29 Anti-Bacterial Agents Phase 3
30 Antibiotics, Antitubercular Phase 3
31 Antitubercular Agents Phase 3
32 Anti-Infective Agents Phase 3
33
Aripiprazole Approved, Investigational Phase 2 129722-12-9 60795
34
Riluzole Approved, Investigational Phase 2 1744-22-5 5070
35
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
36
tannic acid Approved Phase 2 1401-55-4
37
Memantine Approved, Investigational Phase 2 19982-08-2 4054
38
Benzocaine Approved, Investigational Phase 2 1994-09-7, 94-09-7 2337
39
Levoleucovorin Approved, Investigational Phase 2 68538-85-2 149436
40
leucovorin Approved Phase 2 58-05-9 6006
41
Glutamic acid Approved, Nutraceutical Phase 2 56-86-0 33032
42
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
43 Serotonin 5-HT1 Receptor Agonists Phase 2
44 Dopamine agonists Phase 2
45 Serotonin Receptor Agonists Phase 2
46 Adrenergic Antagonists Phase 2
47
Lurasidone hydrochloride Phase 2 367514-87-2 213046
48 Adrenergic alpha-Antagonists Phase 2
49 Anticonvulsants Phase 2
50 Neuroprotective Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 61)
# Name Status NCT ID Phase Drugs
1 A Phase IV, Single-site, Open-Label Study to Evaluate the Efficacy of High-Dose Gammaplex in Children on the Autism Spectrum Unknown status NCT02199925 Phase 4 Gammaplex 5%
2 A Biological Basis of Therapy for Negative Symptom Spectrum Disorders: Risperdal Effect on Frontal Metabolism in Asperger's Disorder Completed NCT00352196 Phase 4 Risperidone
3 Atomoxetine, Placebo and Parent Management Training in Autism Completed NCT00844753 Phase 4 atomoxetine;Placebo
4 Milnacipran in Autism and the Functional Locus Coeruleus and Noradrenergic Model of Autism Completed NCT01337700 Phase 4 Milnacipran;Placebo
5 Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders Completed NCT01178385 Phase 2, Phase 3
6 A Randomized, Placebo-Controlled Trial of D-Cycloserine for the Enhancement of Social Skills Training in Pervasive Developmental Disorders Completed NCT01086475 Phase 3 D-cycloserine;Placebo
7 Efficacy And Safety Of Risperidone In The Treatment Of Children With Autistic Disorder And Other Pervasive Developmental Disorders: A Canadian, Multicenter, Double-Blind, Placebo-Controlled Study Completed NCT00261508 Phase 3 risperidone
8 2/3 Treatment of Anxiety in Autism Spectrum Disorder Completed NCT02028247 Phase 3
9 An Open-Label Study of the Safety and Tolerability of Memantine in Pediatric Patients With Autism, Asperger's Disorder, or Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) Completed NCT01592786 Phase 2 Memantine Hydrochloride (HCl)
10 A Double-Blind, Placebo-Controlled, Randomized Withdrawal Study of the Safety and Efficacy of Memantine in Pediatric Patients With Autism, Asperger's Disorder, or Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) Previously Treated With Memantine Completed NCT01592747 Phase 2 Memantine Hydrochloride (HCl);Memantine Hydrochloride (HCl);Placebo capsules
11 An Open-Label Study of Aripiprazole in Children and Adolescents With Autistic Disorder Completed NCT00198055 Phase 2 aripiprazole
12 CBT for Comorbid Anxiety Disorders in Children With Autism, Asperger Syndrome, or PDD-NOS Completed NCT00280670 Phase 2
13 CBT for Anxiety Disorders in Autism: Adapting Treatment for Adolescents Completed NCT01177969 Phase 1, Phase 2
14 My Scrivener® - Measuring Effectiveness and Dose Response in Children Completed NCT00919906 Phase 1, Phase 2
15 An Open-Label Pilot Study of Lurasidone in Treating Antipsychotic Naive or Quasi-Naive Children and Adolescents Completed NCT01731119 Phase 2 Latuda©
16 Cholesterol in Autism Spectrum Disorder (ASD): Characterization and Treatment Completed NCT00965068 Phase 1, Phase 2
17 The Development of Autistic Children Based on Mother´s Response in Autism Behavior Checklist Completed NCT00725556 Phase 1, Phase 2
18 An Open Label Study of Aripiprazole in Children and Adolescents With Autism Spectrum Disorders Completed NCT00619190 Phase 2 aripiprazole
19 A Prospective Open-Label Trial of Aripiprazole Monotherapy in the Autism Spectrum Disorders (ASD) Completed NCT00308074 Phase 2 Aripiprazole
20 An Investigation of the Efficacy in Childhood Obsessive-Compulsive Disorder of Riluzole: An Antiglutamatergic Agent Completed NCT00251303 Phase 2 Riluzole;Placebo
21 A Pilot Study of Oral N-Acetylcysteine in Children With Autism Spectrum Disorders Completed NCT00453180 Phase 2 N-acetylcysteine;Placebo
22 An Open-Label Extension Study of the Safety and Tolerability of Memantine in Pediatric Patients With Autism, Asperger's Disorder, or Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) Terminated NCT01592773 Phase 2 Memantine Hydrochloride (HCl)
23 A Folinic Acid Intervention for ASD: Links to Folate Receptor-alpha Autoimmunity & Redox Metabolism Terminated NCT01602016 Phase 2 Folinic Acid and placebo;Folinic Acid
24 Repetetive Transcranial Magnetic Stimulation for Evaluation and Treatment of Repetetive Behavior in Subjects With Autism Spectrum Disorders. Terminated NCT01983189 Phase 2
25 An Investigation of the Efficacy of Mercury Chelation as a Treatment for Autism Spectrum Disorder Withdrawn NCT00376194 Phase 2 DMSA
26 Effectiveness of Cognitive-Behavioral Therapy for Children With High-Functioning Autism Spectrum Disorder and Anxiety Completed NCT01187784 Phase 1
27 Evaluation of the French Version of Screening Questionnaires for Autism and Asperger Syndrome : Autism Spectrum Quotient (AQ) Empathy Quotient (EQ) and Systemizing Quotient (SQ) Unknown status NCT00505830
28 Studies of Brain and Body Interaction at Rutgers University Unknown status NCT03672266
29 Phase 2: A Prospective Observational Study of Feasibility and Tentative Effectiveness of Multi-Systemic and Multicomponent Family-Based Intervention for Families of Children With Neuropsychiatric and/or Psychiatric Disorder(s). Unknown status NCT02250339
30 The Multi-media Social Skills Project: Validation of an Intervention for Adolescents With Autism Spectrum Disorders Completed NCT01031823
31 The Use of rTMS to Improve Theory of Mind Among Adults With Autism and Asperger's Disorder Completed NCT00808782
32 Phase II Study of a Portable Visual Guidance System for Use by AS/HFA Students in Inclusion Settings Completed NCT00848874
33 Cognitive Behavioural Therapy and Recreational Activity for Adults With Autism Spectrum Disorders. A Randomized Controlled Trial. Completed NCT01655173
34 Psychopathological Differences Between Asperger Syndrome/Normal IQ, no Language Impairment Autism Spectrum Disorder and Schizotypal Disorder in an Adult Sample Completed NCT02800681
35 Validation of the French Adaptation of the Scale Aiding in the Diagnosis of the Autism Spectrum Disorders : Scale of Asperger Syndrome Diagnosis Completed NCT02826148
36 A Multi-center, Non-drug Study to Explore the Relationship Between Exploratory Biomarkers and Functional Dimensions in Individuals With Autistic Disorder or Asperger's Syndrome. Completed NCT01669889
37 Psychometric Studies of the Chinese Versions of the Social Responsiveness Scale, the Childhood Asperger's Syndrome Test, and the Autism Spectrum Quotient Completed NCT01247662
38 Computer- Assisted Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders Completed NCT01565629
39 Cognitive Behavioral Therapy for Anxiety Disorders in Adolescents With Autism Completed NCT01563003
40 Cognitive Enhancement Therapy for Adult Autism Spectrum Disorder Completed NCT00902798
41 Understanding Caregiver Adaptation to Pervasive Developmental Disorders Completed NCT00496210
42 Shared Decision Making to Improve Care and Outcomes for Children With Autism Completed NCT01921244
43 Exposure-Focused Family-Based CBT for Youth With ASD and Comorbid Anxiety Completed NCT01919970
44 Facilitating Employment for Youth With Autism: A Replication Study of an Internship Model to Identify Evidence Based Practices Completed NCT03560453
45 Advanced Grandparental Age as a Risk Factor for Autism and Other Pervasive Developmental Disorders Completed NCT00464477
46 GroundsKeeper: A Qualitative Study of Applied Game-based Interactives in Special Education Programs Completed NCT01808066
47 fMRI for the Study of Response Inhibition, and Face and Linguistic Processing in Autism Completed NCT00211783
48 Cognitive Neuroscience of Autism Spectrum Disorders Recruiting NCT01031407
49 Evaluation of Patients With Genetic Disorders Recruiting NCT02769949
50 Understanding the Effects of Intervention on the Brain in Autism Recruiting NCT02680015

Search NIH Clinical Center for Asperger Syndrome

Cochrane evidence based reviews: asperger syndrome

Genetic Tests for Asperger Syndrome

Genetic tests related to Asperger Syndrome:

# Genetic test Affiliating Genes
1 Asperger's Disease 29

Anatomical Context for Asperger Syndrome

MalaCards organs/tissues related to Asperger Syndrome:

40
Brain, Cortex, Amygdala, Eye, Cerebellum, Prefrontal Cortex, Temporal Lobe

Publications for Asperger Syndrome

Articles related to Asperger Syndrome:

(show top 50) (show all 1021)
# Title Authors PMID Year
1
Boys with Asperger Syndrome Grow Up: Psychiatric and Neurodevelopmental Disorders 20 Years After Initial Diagnosis. 20 61
26210519 2016
2
Annual Research Review: The role of the environment in the developmental psychopathology of autism spectrum condition. 20
26782158 2016
3
SERT Ileu425Val in autism, Asperger syndrome and obsessive-compulsive disorder. 54 61
18197083 2008
4
Special educational support in children and adolescents with Autism Spectrum Disorder in Germany: Results from a parent survey. 61
33690110 2021
5
Health Services Use and Costs in Individuals with Autism Spectrum Disorder in Germany: Results from a Survey in ASD Outpatient Clinics. 61
33728496 2021
6
The Comorbidity of Schizophrenia Spectrum and Mood Disorders in Autism Spectrum Disorder. 61
33615712 2021
7
[Leisure Opportunities for Autistic Children and Adolescents: How Satisfied are Parents and what do they Think their Children Would Like?] 61
33641644 2021
8
Interpretable Machine Learning Reveals Dissimilarities Between Subtypes of Autism Spectrum Disorder. 61
33719335 2021
9
What Motivates Internet Users to Search for Asperger Syndrome and Autism on Google? 61
33333991 2020
10
First Alarm and Time of Diagnosis in Autism Spectrum Disorders. 61
33090020 2020
11
COVID-19 and psychiatric illness: rectal foreign bodies (30 stylus batteries) in a young male patient affected by Asperger syndrome. 61
33101637 2020
12
Derivation of induced pluripotent stem cells (SDUKIi003-A) from a 20-year-old male patient diagnosed with Asperger syndrome. 61
32916638 2020
13
A de novo frameshift pathogenic variant in TBR1 identified in autism without intellectual disability. 61
32948248 2020
14
[Psychological adaptation in children with autism spectrum disorder and its effect on family quality of life]. 61
32700308 2020
15
Brief Report: Public Awareness of Asperger Syndrome Following Greta Thunberg Appearances. 61
32812193 2020
16
Non-complicit: Revisiting Hans Asperger's Career in Nazi-era Vienna. 61
30887409 2020
17
Psychiatric comorbidities in Asperger syndrome are related with polygenic overlap and differ from other Autism subtypes. 61
32732888 2020
18
What does the future hold for Asperger syndrome? 61
31248755 2020
19
The quality of life and the future of young adults with Asperger syndrome. 61
30669888 2020
20
A case of co-occuring synesthesia, autism, prodigious talent and strong structural brain connectivity. 61
32605557 2020
21
Well-Being and Self-Disorders in Schizotypal Disorder and Asperger Syndrome/Autism Spectrum Disorder. 61
31977719 2020
22
Impaired expression of the COSMOC/MOCOS gene unit in ASD patient stem cells. 61
32327736 2020
23
[Flecainid intoxication: Evolution, complications and care of]. 61
32223907 2020
24
Mismatch negativity to different deviant changes in autism spectrum disorders: A meta-analysis. 61
31952914 2020
25
Utility of the Asperger Syndrome Diagnostic Scale in the Assessment of Autism Spectrum Disorders. 61
31673910 2020
26
Rare genetic susceptibility variants assessment in autism spectrum disorder: detection rate and practical use. 61
32094338 2020
27
Sleep EEG oscillations in neurodevelopmental disorders without intellectual disabilities. 61
31731102 2020
28
Short Report: Social Perception of High School Students with ASD in Norway. 61
31696384 2020
29
[Blessing or curse? The World Wide Web as information source for autism and Asperger Syndrome]. 61
31615331 2020
30
Neuropsychopathology of Autism Spectrum Disorder: Complex Interplay of Genetic, Epigenetic, and Environmental Factors. 61
32006358 2020
31
Self-Disorders in Asperger Syndrome Compared to Schizotypal Disorder: A Clinical Study. 61
31050761 2020
32
Post-traumatic Stress Disorder in an Adolescent with Asperger Syndrome. 61
33370745 2020
33
Internet Use Habits, Parental Control and Psychiatric Comorbidity in Young Subjects with Asperger Syndrome. 61
31564021 2020
34
Neuromarketing Highlights in How Asperger Syndrome Youth Perceive Advertising. 61
33117205 2020
35
Effect of probiotic supplementation on cognitive function in children and adolescents: a systematic review of randomised trials. 61
31965841 2019
36
[Wilson's disease presenting as Asperger syndrome]. 61
31474638 2019
37
[The diagnostics of autism spectrum disorder in children, adolescents and adults: Overview of the key questions and main results of the first part of the German AWMF-S3 - clinical guideline]. 61
30326807 2019
38
Improvising Pragmatic Cognitive-Behavioral Therapy for Depressed Adolescents With Asperger Syndrome. 61
31265767 2019
39
Functional and structural asymmetry in primary motor cortex in Asperger syndrome: a navigated TMS and imaging study. 61
30949863 2019
40
Steroid Metabolites Support Evidence of Autism as a Spectrum. 61
31075898 2019
41
High-Functioning Autism, Severe Anxiety, and Bullying in a 26 Year Old. 61
31008802 2019
42
Age-moderating effect in prepotent response inhibition in boys with Asperger syndrome: a 2.5 years longitudinal study. 61
29942979 2019
43
[Clinical effect of integrated sandplay therapy in children with Asperger syndrome]. 61
30907346 2019
44
Do young people with Asperger syndrome or intellectual disability use social media and are they cyberbullied or cyberbullies in the same way as their peers? 61
30664408 2019
45
Doctors with Asperger's: the impact of a diagnosis. 61
29271086 2019
46
Physiological responses to affiliation during conversation: Comparing neurotypical males and males with Asperger syndrome. 61
31532809 2019
47
Comprehending conjunctive entailment of disjunction among individuals with Asperger syndrome. 61
30889988 2019
48
Subtyping the Autism Spectrum Disorder: Comparison of Children with High Functioning Autism and Asperger Syndrome. 61
30043350 2019
49
Empathy Impairment in Individuals With Autism Spectrum Conditions From a Multidimensional Perspective: A Meta-Analysis. 61
31649570 2019
50
Pathways to a diagnosis of autism spectrum disorder in Germany: a survey of parents. 61
30949235 2019

Variations for Asperger Syndrome

Expression for Asperger Syndrome

Search GEO for disease gene expression data for Asperger Syndrome.

Pathways for Asperger Syndrome

Pathways related to Asperger Syndrome according to KEGG:

36
# Name Kegg Source Accession
1 Cell adhesion molecules hsa04514

Pathways related to Asperger Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.95 SLC6A4 NLGN4X NLGN3 NLGN1 GABRG3 GABRB3
2
Show member pathways
11.71 OXTR OXT AVPR1B AVPR1A
3
Show member pathways
11.45 NLGN4X NLGN3 NLGN1

GO Terms for Asperger Syndrome

Cellular components related to Asperger Syndrome according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.97 SLC6A4 OXTR NLGN4X NLGN3 NLGN1 GABRG3
2 cell junction GO:0030054 9.95 SLC6A4 NLGN4X NLGN3 NLGN1 GABRG3 GABRB3
3 synapse GO:0045202 9.86 SLC6A4 NLGN4X NLGN3 NLGN1 MECP2 GABRG3
4 presynapse GO:0098793 9.78 SLC6A4 NLGN4X NLGN3 NLGN1
5 integral component of postsynaptic membrane GO:0099055 9.63 SLC6A4 NLGN3 NLGN1
6 postsynapse GO:0098794 9.55 NLGN3 NLGN1 MECP2 GABRG3 BDNF
7 excitatory synapse GO:0060076 9.54 NLGN4X NLGN3 NLGN1
8 GABA-A receptor complex GO:1902711 9.49 GABRG3 GABRB3
9 symmetric, GABA-ergic, inhibitory synapse GO:0098983 9.43 NLGN4X NLGN3
10 spanning component of membrane GO:0089717 9.13 NLGN4X NLGN3 NLGN1
11 asymmetric, glutamatergic, excitatory synapse GO:0098985 8.8 NLGN4X NLGN3 NLGN1

Biological processes related to Asperger Syndrome according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 9.92 OXTR OXT AVPR1B AVPR1A
2 response to estradiol GO:0032355 9.87 SLC6A4 OXTR OXT ARNT2
3 chemical synaptic transmission GO:0007268 9.85 NLGN4X NLGN3 NLGN1 MECP2 GABRG3 GABRB3
4 modulation of chemical synaptic transmission GO:0050804 9.84 NLGN4X NLGN3 NLGN1 BDNF
5 learning GO:0007612 9.82 NLGN4X NLGN3 MECP2
6 synapse organization GO:0050808 9.81 NLGN4X NLGN3 NLGN1
7 synapse assembly GO:0007416 9.8 NLGN3 NLGN1 MECP2 BDNF
8 synaptic vesicle endocytosis GO:0048488 9.78 NLGN4X NLGN3 NLGN1
9 positive regulation of vasoconstriction GO:0045907 9.77 OXTR AVPR1B AVPR1A
10 activation of phospholipase C activity GO:0007202 9.76 BDNF AVPR1B AVPR1A
11 positive regulation of synaptic transmission, glutamatergic GO:0051968 9.75 OXTR NLGN3 NLGN1
12 positive regulation of blood pressure GO:0045777 9.72 OXTR OXT AVPR1A
13 neuron cell-cell adhesion GO:0007158 9.7 NLGN4X NLGN3 NLGN1
14 presynapse assembly GO:0099054 9.69 NLGN4X NLGN3 NLGN1
15 vocalization behavior GO:0071625 9.66 NLGN4X NLGN3
16 positive regulation of renal sodium excretion GO:0035815 9.66 OXT AVPR1A
17 grooming behavior GO:0007625 9.65 OXT AVPR1A
18 positive regulation of synaptic transmission, GABAergic GO:0032230 9.65 OXTR NLGN1
19 sleep GO:0030431 9.65 OXTR OXT
20 regulation of respiratory gaseous exchange by neurological system process GO:0002087 9.65 NLGN3 NLGN1 MECP2
21 memory GO:0007613 9.65 SLC6A4 OXTR OXT MECP2 BDNF
22 positive regulation of uterine smooth muscle contraction GO:0070474 9.64 OXTR OXT
23 negative regulation of gastric acid secretion GO:0060455 9.63 OXTR OXT
24 presynaptic membrane assembly GO:0097105 9.63 NLGN4X NLGN3 NLGN1
25 positive regulation of penile erection GO:0060406 9.62 OXTR OXT
26 positive regulation of norepinephrine secretion GO:0010701 9.61 OXTR OXT
27 maternal behavior GO:0042711 9.61 OXTR OXT AVPR1A
28 maternal aggressive behavior GO:0002125 9.6 OXT AVPR1A
29 postsynaptic membrane assembly GO:0097104 9.58 NLGN4X NLGN3 NLGN1
30 regulation of digestive system process GO:0044058 9.56 OXTR OXT
31 positive regulation of synapse assembly GO:0051965 9.55 OXTR OXT NLGN3 NLGN1 BDNF
32 regulation of systemic arterial blood pressure by vasopressin GO:0001992 9.5 OXTR AVPR1B AVPR1A
33 sperm ejaculation GO:0042713 9.26 SLC6A4 OXTR OXT AVPR1A
34 social behavior GO:0035176 9.17 SLC6A4 OXTR OXT NLGN4X NLGN3 MECP2

Molecular functions related to Asperger Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion molecule binding GO:0050839 9.5 NLGN4X NLGN3 NLGN1
2 peptide binding GO:0042277 9.43 OXTR AVPR1B AVPR1A
3 GABA-A receptor activity GO:0004890 9.4 GABRG3 GABRB3
4 GABA-gated chloride ion channel activity GO:0022851 9.37 GABRG3 GABRB3
5 scaffold protein binding GO:0097110 9.33 NLGN4X NLGN3 NLGN1
6 neurexin family protein binding GO:0042043 9.13 NLGN4X NLGN3 NLGN1
7 vasopressin receptor activity GO:0005000 8.8 OXTR AVPR1B AVPR1A

Sources for Asperger Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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