Asperger Syndrome

Categories: Rare diseases, Mental diseases

Aliases & Classifications for Asperger Syndrome

MalaCards integrated aliases for Asperger Syndrome:

Name: Asperger Syndrome 12 76 53 54 37 55 44 15 73
Asperger's Disease 29
Asperger Disorder 53


External Ids:

Disease Ontology 12 DOID:0050432
ICD10 33 F84.5
MeSH 44 D020817
NCIt 50 C97159
KEGG 37 H01882
UMLS 73 C0236792

Summaries for Asperger Syndrome

NIH Rare Diseases : 53 Asperger syndrome is part of the autism spectrum disorder (ASD), a group of disorders that affects the development of social and communication skills. Unlike many children with ASD, children with Asperger syndrome do not have early language delays, and often have well developed language skills and normal to above average intelligence. However, they may use unusual speech patterns and have a hard time understanding irony, humor, and sarcasm or gestures and social cues important to normal conversation. Many children with Asperger syndrome develop an obsessive interest in one topic or object. They may use high-level vocabulary or complex statistics in conversation. Children with Asperger syndrome may have delayed motor skills and thus can appear uncoordinated and clumsy compared to their peers. Other features of Asperger syndrome include difficulty interacting with peers, inappropriate social or emotional behavior, and engaging in repetitive routines. Both children and adults with Asperger syndrome are at an increased risk for depression, attention deficit hyperactivity disorder (ADHD), mood and anxiety disorders, and other mental health disorders. The cause of Asperger syndrome, like most ASDs, is not fully understood, but there is a strong genetic basis, which means it does tend to run in families. Multiple environmental factors are also thought to play an important role in the development of all ASDs.Treatment for Asperger syndrome depends on each person's age and needs, and the recommendation is for treatment to begin as early as possible. Many people with Asperger syndrome can learn strategies to manage their symptoms. Treatment may include behavioral therapy, speech and language therapy, support in school, and mental health counseling. Medications may sometimes be used for behavioral or mood disorders.  Of note: the  newest edition, updated in 2013, of the Diagnostic and Statistical Manual of Mental Disorders(DSM-V), which is used predominantly in the United States (US), replaced the terms Asperger syndrome and other pervasive developmental disorders with the umbrella diagnosis of autism spectrum disorder. This means that currently, Asperger syndrome is not officially considered a separate disorder in US, but instead it is now part of the autism spectrum disorder (ASD). However, many doctors still use this term. The World Health Organization International Classification of Diseases, (ICD-11) which is used in other countries throughout the world still uses Asperger syndrome as a subtype of ASD.

MalaCards based summary : Asperger Syndrome, also known as asperger's disease, is related to atypical autism and autism spectrum disorder. An important gene associated with Asperger Syndrome is ASPG2 (Asperger Syndrome, Susceptibility To, 2), and among its related pathways/superpathways are Cell adhesion molecules (CAMs) and Transmission across Chemical Synapses. The drugs Dopamine and Risperidone have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and eye, and related phenotypes are behavior/neurological and endocrine/exocrine gland

NINDS : 54 Asperger syndrome (AS) is a developmental disorder.  It is an autism spectrum disorder (ASD), one of a distinct group of neurological conditions characterized by a greater or lesser degree of impairment in language and communication skills, as well as repetitive or restrictive patterns of thought and behavior.  Other ASDs include:  classic autism, Rett syndrome, childhood disintegrative disorder, and pervasive developmental disorder not otherwise specified (usually referred to as PDD-NOS). Unlike children with autism, children with AS retain their early language skills. The most distinguishing symptom of AS is a child’s obsessive interest in a single object or topic to the exclusion of any other.  Children with AS want to know everything about their topic of interest and their conversations with others will be about little else.  Their expertise, high level of vocabulary, and formal speech patterns make them seem like little professors.  Other characteristics of AS include repetitive routines or rituals; peculiarities in speech and language; socially and emotionally inappropriate behavior and the inability to interact successfully with peers; problems with non-verbal communication; and clumsy and uncoordinated motor movements. Children with AS are isolated because of their poor social skills and narrow interests.  They may approach other people, but make normal conversation impossible by inappropriate or eccentric behavior, or by wanting only to talk about their singular interest.    Children with AS usually have a history of developmental delays in motor skills such as pedaling a bike, catching a ball, or climbing outdoor play equipment.   They are often awkward and poorly coordinated with a walk that can appear either stilted or bouncy. 

Disease Ontology : 12 An autism spectrum disorder that is characterized by significant difficulties in social interaction, along with restricted and repetitive patterns of behavior and interests. It differs from other autism spectrum disorders by its relative preservation of linguistic and cognitive development.

Wikipedia : 76 Asperger syndrome (AS), also known as Asperger\'s, is a developmental disorder characterized by... more...

Related Diseases for Asperger Syndrome

Diseases in the Asperger Syndrome family:

Asperger Syndrome 2 Asperger Syndrome 1
Asperger Syndrome 3 Asperger Syndrome 4

Diseases related to Asperger Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 atypical autism 30.5 NLGN3 NLGN4X OXTR
2 autism spectrum disorder 30.3 AVPR1A GABRB3 NLGN3 NLGN4X OXT OXTR
4 obsessive-compulsive disorder 29.9 OXT SGCE SLC6A4
5 psychotic disorder 29.7 DISC1 GABRB3 SHANK3 SLC6A4
6 asperger syndrome, x-linked 1 12.4
7 asperger syndrome, x-linked 2 12.4
8 asperger syndrome 2 12.3
9 asperger syndrome 3 12.3
10 asperger syndrome 1 12.3
11 asperger syndrome 4 12.3
12 autism x-linked 1 11.0
13 autism x-linked 2 11.0
14 autism x-linked 3 11.0
15 autism x-linked 4 11.0
16 autism x-linked 5 11.0
17 autism x-linked 6 11.0
18 autism 5 11.0
19 autism 8 11.0
20 autism 3 11.0
21 autism 6 11.0
22 autism 7 11.0
23 autism 11 11.0
24 autism 12 11.0
25 autism 13 11.0
26 autism 9 11.0
27 autism 10 11.0
28 autism 15 11.0
29 autism 16 11.0
30 autism 17 11.0
31 autism 18 11.0
32 childhood disintegrative disease 10.5 GABRB3 SHANK3
33 aging 10.2
34 anxiety 10.2
35 schizophrenia 10.2
36 learning disability 10.1
37 depression 10.0
38 attention deficit-hyperactivity disorder 10.0
39 acth-independent macronodular adrenal hyperplasia 10.0 AVPR1A AVPR1B
40 cognitive function 1, social 9.9
41 personality disorder 9.9
42 prosopagnosia 9.9
43 dysphasia, familial developmental 9.8
44 anorexia nervosa 9.8
45 specific language impairment 9.8
46 gender identity disorder 9.8
47 conduct disorder 9.8
48 myotonic dystrophy 9.8
49 myotonia atrophica 9.8
50 disease of mental health 9.7 DISC1 OXT OXTR SHANK3 SLC6A4

Graphical network of the top 20 diseases related to Asperger Syndrome:

Diseases related to Asperger Syndrome

Symptoms & Phenotypes for Asperger Syndrome

MGI Mouse Phenotypes related to Asperger Syndrome:

# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 AVPR1A AVPR1B CYP11B1 DISC1 GABRB3 NLGN3
2 endocrine/exocrine gland MP:0005379 9.56 ARNT2 AVPR1A AVPR1B CYP11B1 OXT OXTR
3 nervous system MP:0003631 9.4 AVPR1B DISC1 GABRB3 NLGN3 OXT OXTR

Drugs & Therapeutics for Asperger Syndrome

Drugs for Asperger Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 105)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Dopamine Approved Phase 4,Phase 3,Phase 2,Not Applicable 51-61-6, 62-31-7 681
Risperidone Approved, Investigational Phase 4,Phase 3,Not Applicable 106266-06-2 5073
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
Choline Approved, Nutraceutical Phase 4 62-49-7 305
Creatine Approved, Investigational, Nutraceutical Phase 4 57-00-1 586
8 Antibodies Phase 4
9 gamma-Globulins Phase 4
10 Immunoglobulins Phase 4
11 Immunoglobulins, Intravenous Phase 4
12 Rho(D) Immune Globulin Phase 4
13 Antipsychotic Agents Phase 4,Phase 3,Phase 2,Not Applicable
14 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
15 Dopamine Agents Phase 4,Phase 3,Phase 2,Not Applicable
16 Dopamine Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
17 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
18 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Not Applicable
19 Serotonin Agents Phase 4,Phase 3,Phase 2,Not Applicable
20 Serotonin Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
21 Tranquilizing Agents Phase 4,Phase 3,Phase 2,Not Applicable
22 Adrenergic Agents Phase 4,Phase 3,Phase 2
23 Antidepressive Agents Phase 4,Phase 3,Phase 2
24 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2
25 Serotonin Uptake Inhibitors Phase 4,Phase 2
26 Atomoxetine Hydrochloride Phase 4,Phase 3
27 Central Nervous System Stimulants Phase 4
28 Dopamine Uptake Inhibitors Phase 4
29 Adrenergic Agonists Phase 4
30 Adrenergic alpha-2 Receptor Agonists Phase 4
31 Adrenergic alpha-Agonists Phase 4
32 Antihypertensive Agents Phase 4
Phosphocreatine Nutraceutical Phase 4 67-07-2 587
Serotonin Investigational, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 50-67-9 5202
Cycloserine Approved Phase 3 68-41-7 401 6234
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
Mianserin Approved, Investigational Phase 3 24219-97-4 4184
Mirtazapine Approved Phase 3 85650-52-8, 61337-67-5 4205
Ziprasidone Approved Phase 3 146939-27-7 60854
Ethanol Approved Phase 2, Phase 3 64-17-5 702
2-Phenylethanol Experimental Phase 2, Phase 3 60-12-8 6054
42 Anti-Bacterial Agents Phase 3
43 Antibiotics, Antitubercular Phase 3
44 Anti-Infective Agents Phase 3,Phase 2
45 Antimetabolites Phase 3
46 Antitubercular Agents Phase 3
47 Renal Agents Phase 3
48 Adrenergic alpha-Antagonists Phase 3,Phase 2
49 Adrenergic Antagonists Phase 3,Phase 2
50 Antidepressive Agents, Second-Generation Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 88)
# Name Status NCT ID Phase Drugs
1 An Open-Label Study to Evaluate the Efficacy of High-Dose Gammaplex in Children on the Autism Spectrum Unknown status NCT02199925 Phase 4 Gammaplex 5%
2 Janssen Asperger's MRS (Magnetic Resonance Spectroscopy Risperidone Study Completed NCT00352196 Phase 4 Risperidone
3 Milnacipran in Autism and the Functional Locus Coeruleus and Noradrenergic Model of Autism Completed NCT01337700 Phase 4 Milnacipran;Placebo
4 Atomoxetine, Placebo and Parent Management Training in Autism Completed NCT00844753 Phase 4 atomoxetine;Placebo
5 Methylphenidate ER Liquid Formulation in Adults With ASD and ADHD Completed NCT02096952 Phase 4 Methylphenidate extended-release liquid formulation
6 Guanfacine for the Treatment of Hyperactivity in Pervasive Developmental Disorder Completed NCT01238575 Phase 4 extended-release guanfacine
7 Effectiveness of Atomoxetine in Treating ADHD Symptoms in Children and Adolescents With Autism Completed NCT00498173 Phase 3 Atomoxetine;Placebo
8 D-Cycloserine and Social Skills Training in Autism Spectrum Disorders Completed NCT01086475 Phase 3 D-cycloserine;Placebo
9 Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders Completed NCT01178385 Phase 2, Phase 3
10 A Study of the Effectiveness and Safety of Risperidone Versus Placebo in the Treatment of Children With Autistic Disorder and Other Pervasive Developmental Disorders (PDD) Completed NCT00261508 Phase 3 risperidone
11 Mirtazapine Treatment of Anxiety in Children and Adolescents With Pervasive Developmental Disorders Recruiting NCT01302964 Phase 3 Placebo;Mirtazapine;Mirtazapine
12 Psychotherapy for Anxiety in Children With Autism Spectrum Disorder Active, not recruiting NCT02028247 Phase 3
13 A Study of Pediatric Participants With Attention Deficit/Hyperactivity Disorder Terminated NCT00965419 Phase 2, Phase 3 Edivoxetine
14 An Open-Label Safety Study of Memantine in Pediatric Patients With Autism, Asperger's Disorder, or Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) Completed NCT01592786 Phase 2 Memantine Hydrochloride (HCl)
15 Withdrawal Study of Memantine in Pediatric Patients With Autism, Asperger's Disorder, or Pervasive Developmental Disorder Not Otherwise Specified Previously Treated With Memantine Completed NCT01592747 Phase 2 Memantine Hydrochloride (HCl);Memantine Hydrochloride (HCl);Placebo capsules
16 CBT for Comorbid Anxiety Disorders in Children With Autism, Asperger Syndrome, or PDD-NOS Completed NCT00280670 Phase 2
17 The Development of Autistic Children Based on Mothers´Response in Autism Behavior Checklist Completed NCT00725556 Phase 1, Phase 2
18 Cognitive Behavioral Therapy (CBT) for Anxiety Disorders in Autism: Adapting Treatment for Adolescents Completed NCT01177969 Phase 1, Phase 2
19 A Study of Aripiprazole in Children and Adolescents With Aspergers and Pervasive Developmental Disorder. Completed NCT00198055 Phase 2 aripiprazole
20 A Study of Oral N-Acetylcysteine in Children With Autism Spectrum Disorders Completed NCT00453180 Phase 2 N-acetylcysteine;Placebo
21 Study of Aripiprazole to Treat Children and Adolescents With Autism Completed NCT00619190 Phase 2 aripiprazole
22 Cholesterol in ASD: Characterization and Treatment Completed NCT00965068 Phase 1, Phase 2
23 An Open-Label Trial of Aripiprazole in Autism Spectrum Disorders Completed NCT00308074 Phase 2 Aripiprazole
24 Omega-3 Fatty Acids For Treatment Of Young Children With Autism (OMG) Completed NCT01248728 Phase 2
25 Study of Arbaclofen for the Treatment of Social Withdrawal in Subjects With Autism Spectrum Disorders Completed NCT01288716 Phase 2 Arbaclofen
26 Riluzole to Treat Child and Adolescent Obsessive-Compulsive Disorder With or Without Autism Spectrum Disorders Completed NCT00251303 Phase 2 Riluzole;Placebo
27 My Scrivener® - Measuring Effectiveness and Dose Response in Children Completed NCT00919906 Phase 1, Phase 2
28 Study of Lurasidone in Treating Antipsychotic Naive or Quasi-Naive Children and Adolescents Completed NCT01731119 Phase 2 Latuda©
29 Citalopram for Children With Autism and Repetitive Behavior (STAART Study 1) Completed NCT00086645 Phase 2 citalopram hydrobromide
30 Essential Oils for Enhancing QOL in ASD Recruiting NCT02543203 Phase 2
31 Safety Study of Memantine in Pediatric Patients With Autism, Asperger's Disorder or Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) Terminated NCT01592773 Phase 2 Memantine Hydrochloride (HCl)
32 Transcranial Magnetic Stimulation for Evaluation and Treatment of Repetetive Behaviors in Autism Terminated NCT01983189 Phase 2
33 Deep rTMS (Repetitive Transcranial Magnetic Stimulation)for Treatment of Autism Symptoms in Children. Terminated NCT01388179 Phase 2
34 A Folinic Acid Intervention for Autism Spectrum Disorders Terminated NCT01602016 Phase 2 Folinic Acid and placebo;Folinic Acid
35 Mercury Chelation to Treat Autism Withdrawn NCT00376194 Phase 2 DMSA
36 Cognitive-Behavioral Therapy for Children With High-Functioning Autism Spectrum Disorder and Anxiety Completed NCT01187784 Phase 1
37 Evaluation of the French Version of Screening Questionnaires for Autism and Asperger Syndrome: AQ, EQ and SQ Unknown status NCT00505830
38 Portable Visual Guidance System Phase II Unknown status NCT00848874 Not Applicable
39 Adolescent Social Skills Training Program Unknown status NCT01031823 Not Applicable
40 Cognitive-Behavioral Therapy for Irritability in Adolescents With High Functioning Autism Spectrum Disorder Unknown status NCT01631851 Not Applicable
41 A Longitudinal Follow-up Imaging Study on Children and Adolescents With Autism Spectrum Disorder Unknown status NCT02719067
42 ASD-specific Induced Pluripotent Stem Cells for Disease Modeling Unknown status NCT02720939
43 A Salivary miRNA Diagnostic Test for Autism Unknown status NCT02832557
44 Investigating Neuroimaging Endophenotypes for Autism Spectrum Disorder Unknown status NCT02720588
45 A Non-Drug Study on the Relationship Between Exploratory Biomarkers and Functional Dimensions in Individuals With Autistic Disorder or Asperger's Syndrome Completed NCT01669889
46 The Use of rTMS to Improve Theory of Mind Among Adults With Autism and Asperger's Disorder Completed NCT00808782 Not Applicable
47 Validation of the French Adaptation of the RAADS-R Scale : Scale of Asperger Syndrome Diagnosis Completed NCT02826148 Not Applicable
48 Psychometric Studies of the Chinese Versions of the SRS, CAST, and AQ Completed NCT01247662
49 Functional Magnetic Resonance Imaging (fMRI) for the Study of Response Inhibition, and Face and Linguistic Processing in Autism Completed NCT00211783
50 Cognitive Behavioural Therapy (CBT) and Recreational Activity for Autism Spectrum Disorders (ASD) Completed NCT01655173 Not Applicable

Search NIH Clinical Center for Asperger Syndrome

Cochrane evidence based reviews: asperger syndrome

Genetic Tests for Asperger Syndrome

Genetic tests related to Asperger Syndrome:

# Genetic test Affiliating Genes
1 Asperger's Disease 29

Anatomical Context for Asperger Syndrome

MalaCards organs/tissues related to Asperger Syndrome:

Testes, Brain, Eye, Amygdala, Temporal Lobe, Skin, Cortex

Publications for Asperger Syndrome

Articles related to Asperger Syndrome:

(show top 50) (show all 479)
# Title Authors Year
Age-moderating effect in prepotent response inhibition in boys with Asperger syndrome: a 2.5A years longitudinal study. ( 29942979 )
Impaired detection and differentiation of briefly presented facial emotions in adults with high-functioning autism and asperger syndrome. ( 29477010 )
A Case of Asperger Syndrome With Comorbidity of Posttraumatic Stress Disorder and Selective Mutism: Significant Remission With the Combination of Aripiprazole and Eye Movement Desensitization and Reprocessing. ( 27977468 )
Behavioral, Cognitive and Neural Markers of Asperger Syndrome. ( 29167722 )
Asperger syndrome and schizophrenia: I9eurodevelopmental continuum or separated clinical entities? ( 28686564 )
Role of Two Types of Syntactic Embedding in Belief Attribution in Adults with or without Asperger Syndrome. ( 28553246 )
Asperger syndrome and early-onset schizophrenia associated with a novel MECP2 deleterious missense variant. ( 28230711 )
The effect of methylphenidate on anxiety and depression symptoms in patients with Asperger syndrome and comorbid attention deficit/hyperactivity disorder. ( 28368900 )
Family functioning, parenting stress and quality of life in mothers and fathers of Polish children with high functioning autism or Asperger syndrome. ( 29036188 )
From High Intellectual Potential to Asperger Syndrome: Evidence for Differences and a Fundamental Overlap-A Systematic Review. ( 27812341 )
Romantic Relationships and Relationship Satisfaction Among Adults With Asperger Syndrome and High-Functioning Autism. ( 27196958 )
The People with Asperger syndrome and anxiety disorders (PAsSA) trial: a pilot multicentre, single-blind randomised trial of group cognitive-behavioural therapy. ( 27703772 )
Exploratory Study of Childbearing Experiences of Women With Asperger Syndrome. ( 26902438 )
Neuroanatomical Markers of Neurological Soft Signs in Recent-Onset Schizophrenia and Asperger-Syndrome. ( 26708327 )
Age-related differences in inhibitory control and memory updating in boys with Asperger syndrome. ( 28025692 )
Effects of multisensory yoga on behavior in a male child with Apert and Asperger syndrome. ( 26865777 )
Asperger syndrome in males over two decades: Quality of life in relation to diagnostic stability and psychiatric comorbidity. ( 27233289 )
Asperger syndrome in childhood - personality dimensions in adult life: temperament, character and outcome trajectories. ( 27703778 )
Do Adults with High Functioning Autism or Asperger Syndrome Differ in Empathy and Emotion Recognition? ( 26883645 )
Asperger Syndrome and Schizophrenia: A Comparative Neuropsychological Study. ( 26936160 )
Crohn's Disease and Asperger Syndrome: Not Just a Coincidence? ( 27104829 )
The Hyper-Modular Associative Mind: A Computational Analysis of Associative Responses of Persons with Asperger Syndrome. ( 29924527 )
Impaired social cognition processes in Asperger syndrome and anorexia nervosa. In search for endophenotypes of social cognition. ( 27556112 )
The Occupational Transition Process to Upper Secondary School, Further Education and/or Work in Sweden: As Described by Young Adults with Asperger Syndrome and Attention Deficit Hyperactivity Disorder. ( 28005233 )
Evaluation of Asperger Syndrome in Youth Presenting to a Gender Dysphoria Clinic. ( 26651183 )
Beyond childhood: psychiatric comorbidities and social background of adults with Asperger syndrome. ( 25751431 )
Genetic variant rs17225178 in the ARNT2 gene is associated with Asperger Syndrome. ( 25745553 )
Asperger syndrome in India: findings from a case-series with respect to clinical profile and comorbidity. ( 25969609 )
Boys with Asperger Syndrome Grow Up: Psychiatric and Neurodevelopmental Disorders 20A Years After Initial Diagnosis. ( 26210519 )
3p22.1p21.31 microdeletion identifies CCK as Asperger syndrome candidate gene and shows the way for therapeutic strategies in chromosome imbalances. ( 26523151 )
Early-onset anorexia nervosa in girls with Asperger syndrome. ( 26170676 )
A Pooled Genome-Wide Association Study of Asperger Syndrome. ( 26176695 )
A Concise History of Asperger Syndrome: The Short Reign of a Troublesome Diagnosis. ( 26834663 )
Constrained spherical deconvolution-based tractography and tract-based spatial statistics show abnormal microstructural organization in Asperger syndrome. ( 25874076 )
Correlation between chromatic sensitivity and higher order color vision functions in Asperger Syndrome but not in high functioning autism. ( 26325950 )
Late diagnosis of Asperger syndrome in Croatia - a low-income country. ( 26609658 )
The Puberty Video for Boys with Asperger Syndrome (and Autism Spectrum Disorder: Level 1) DVD $25.00, 48A Minutes and Managing Puberty, Social Challenges, and (Almost) Everything: A Video Guide for Girls: DVD, $25.00, 80 Minutes; Coulter Video ( ( 25432100 )
Repetition, response mobilization, and face: Analysis of group interactions with a 19-year-old with Asperger syndrome. ( 26026646 )
Substance use disorder in Asperger syndrome: An investigation into the development and maintenance of substance use disorder by individuals with a diagnosis of Asperger syndrome. ( 26187185 )
Incidental diagnosis of HLRCC following investigation for Asperger Syndrome: actionable and actioned. ( 26275867 )
Group training in interpersonal problem-solving skills for workplace adaptation of adolescents and adults with Asperger syndrome: A preliminary study. ( 24569569 )
Gaze and visual search strategies of children with Asperger syndrome/high functioning autism viewing a magic trick. ( 24866104 )
Atypical prosody in Asperger syndrome: perceptual and acoustic measurements. ( 24590408 )
I Collect Therefore I am-Autonoetic Consciousness and Hoarding in Asperger Syndrome. ( 24615808 )
Asperger syndrome and schizophrenia: Overlap of self-reported autistic traits using the Autism-spectrum Quotient (AQ). ( 25389915 )
History of suicide attempts in adults with Asperger syndrome. ( 25113892 )
Piloting the use of experience sampling method to investigate the everyday social experiences of children with Asperger syndrome/high functioning autism. ( 24840290 )
Genetic variation in the oxytocin receptor (OXTR) gene is associated with Asperger Syndrome. ( 25264479 )
Automatic conversational scene analysis in children with Asperger syndrome/high-functioning autism and typically developing peers. ( 24489674 )
STX1A and Asperger syndrome: a replication study. ( 24548729 )

Variations for Asperger Syndrome

Expression for Asperger Syndrome

Search GEO for disease gene expression data for Asperger Syndrome.

Pathways for Asperger Syndrome

Pathways related to Asperger Syndrome according to KEGG:

# Name Kegg Source Accession
1 Cell adhesion molecules (CAMs) hsa04514

Pathways related to Asperger Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways

GO Terms for Asperger Syndrome

Cellular components related to Asperger Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 postsynaptic membrane GO:0045211 9.62 DISC1 GABRB3 NLGN4X SHANK3
2 integral component of plasma membrane GO:0005887 9.56 AVPR1A AVPR1B GABRB3 NLGN3 NLGN4X OXTR
3 excitatory synapse GO:0060076 9.37 NLGN3 NLGN4X
4 spanning component of membrane GO:0089717 9.26 NLGN3 NLGN4X
5 asymmetric, glutamatergic, excitatory synapse GO:0098985 9.16 NLGN3 NLGN4X
6 symmetric, GABA-ergic, inhibitory synapse GO:0098983 8.62 NLGN3 NLGN4X

Biological processes related to Asperger Syndrome according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 9.88 AVPR1A AVPR1B OXT OXTR
2 learning GO:0007612 9.78 NLGN3 NLGN4X SHANK3
3 response to estradiol GO:0032355 9.78 ARNT2 OXT OXTR SLC6A4
4 positive regulation of synapse assembly GO:0051965 9.77 NLGN3 OXT OXTR
5 positive regulation of vasoconstriction GO:0045907 9.71 AVPR1A AVPR1B OXTR
6 memory GO:0007613 9.71 OXT OXTR SHANK3 SLC6A4
7 adult behavior GO:0030534 9.7 NLGN3 NLGN4X SHANK3
8 telencephalon development GO:0021537 9.69 AVPR1A OXTR
9 positive regulation of synaptic transmission, glutamatergic GO:0051968 9.69 NLGN3 OXTR SHANK3
10 synaptic vesicle endocytosis GO:0048488 9.68 NLGN3 NLGN4X
11 eating behavior GO:0042755 9.68 OXT OXTR
12 response to amphetamine GO:0001975 9.68 OXT OXTR
13 activation of phospholipase C activity GO:0007202 9.68 AVPR1A AVPR1B
14 positive regulation of excitatory postsynaptic potential GO:2000463 9.67 NLGN3 SHANK3
15 regulation of AMPA receptor activity GO:2000311 9.67 NLGN3 SHANK3
16 brain morphogenesis GO:0048854 9.67 SHANK3 SLC6A4
17 neuron cell-cell adhesion GO:0007158 9.66 NLGN3 NLGN4X
18 regulation of dendritic spine morphogenesis GO:0061001 9.66 NLGN3 SHANK3
19 positive regulation of renal sodium excretion GO:0035815 9.65 AVPR1A OXT
20 grooming behavior GO:0007625 9.65 AVPR1A OXT
21 presynaptic membrane assembly GO:0097105 9.65 NLGN3 NLGN4X
22 regulation of long-term synaptic potentiation GO:1900271 9.64 NLGN3 SHANK3
23 sleep GO:0030431 9.64 OXT OXTR
24 presynapse assembly GO:0099054 9.63 NLGN3 NLGN4X
25 negative regulation of excitatory postsynaptic potential GO:0090394 9.63 NLGN3 NLGN4X
26 positive regulation of blood pressure GO:0045777 9.63 AVPR1A OXT OXTR
27 postsynaptic membrane assembly GO:0097104 9.62 NLGN3 NLGN4X
28 inhibitory postsynaptic potential GO:0060080 9.62 GABRB3 NLGN3
29 positive regulation of uterine smooth muscle contraction GO:0070474 9.61 OXT OXTR
30 response to peptide GO:1901652 9.61 AVPR1A AVPR1B OXTR
31 negative regulation of gastric acid secretion GO:0060455 9.59 OXT OXTR
32 positive regulation of AMPA receptor activity GO:2000969 9.58 NLGN3 SHANK3
33 maternal aggressive behavior GO:0002125 9.57 AVPR1A OXT
34 positive regulation of penile erection GO:0060406 9.56 OXT OXTR
35 cellular response to hormone stimulus GO:0032870 9.56 AVPR1A AVPR1B CYP11B1 OXTR
36 positive regulation of norepinephrine secretion GO:0010701 9.55 OXT OXTR
37 vocalization behavior GO:0071625 9.54 NLGN3 NLGN4X SHANK3
38 maternal behavior GO:0042711 9.5 AVPR1A OXT OXTR
39 regulation of digestive system process GO:0044058 9.49 OXT OXTR
40 regulation of systemic arterial blood pressure by vasopressin GO:0001992 9.33 AVPR1A AVPR1B OXTR
41 sperm ejaculation GO:0042713 9.26 AVPR1A OXT OXTR SLC6A4
42 social behavior GO:0035176 9.17 AVPR1A NLGN3 NLGN4X OXT OXTR SHANK3

Molecular functions related to Asperger Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide binding GO:0042277 9.33 AVPR1A AVPR1B OXTR
2 neurexin family protein binding GO:0042043 9.26 NLGN3 NLGN4X
3 scaffold protein binding GO:0097110 9.13 NLGN3 NLGN4X SHANK3
4 vasopressin receptor activity GO:0005000 8.8 AVPR1A AVPR1B OXTR

Sources for Asperger Syndrome

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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