MCID: ASP001
MIFTS: 51

Asperger Syndrome

Categories: Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Asperger Syndrome

MalaCards integrated aliases for Asperger Syndrome:

Name: Asperger Syndrome 12 76 53 37 55 44 15 73
Asperger's Disease 29
Asperger Disorder 53

Classifications:



External Ids:

Disease Ontology 12 DOID:0050432
ICD10 33 F84.5
MeSH 44 D020817
NCIt 50 C97159
SNOMED-CT 68 23560001
KEGG 37 H01882
UMLS 73 C0236792

Summaries for Asperger Syndrome

NIH Rare Diseases : 53 Asperger syndrome is part of the autism spectrum disorder (ASD), a group of disorders that affects the development of social and communication skills. Unlike many children with ASD, children with Asperger syndrome do not have early language delays, and often have well developed language skills and normal to above average intelligence. However, they may use unusual speech patterns and have a hard time understanding irony, humor, and sarcasm or gestures and social cues important to normal conversation. Many children with Asperger syndrome develop an obsessive interest in one topic or object. They may use high-level vocabulary or complex statistics in conversation. Children with Asperger syndrome may have delayed motor skills and thus can appear uncoordinated and clumsy compared to their peers. Other features of Asperger syndrome include difficulty interacting with peers, inappropriate social or emotional behavior, and engaging in repetitive routines. Both children and adults with Asperger syndrome are at an increased risk for depression, attention deficit hyperactivity disorder (ADHD), mood and anxiety disorders, and other mental health disorders. The cause of Asperger syndrome, like most ASDs, is not fully understood, but there is a strong genetic basis, which means it does tend to run in families. Multiple environmental factors are also thought to play an important role in the development of all ASDs.Treatment for Asperger syndrome depends on each person's age and needs, and the recommendation is for treatment to begin as early as possible. Many people with Asperger syndrome can learn strategies to manage their symptoms. Treatment may include behavioral therapy, speech and language therapy, support in school, and mental health counseling. Medications may sometimes be used for behavioral or mood disorders.  Of note: the  newest edition, updated in 2013, of the Diagnostic and Statistical Manual of Mental Disorders(DSM-V), which is used predominantly in the United States (US), replaced the terms Asperger syndrome and other pervasive developmental disorders with the umbrella diagnosis of autism spectrum disorder. This means that currently, Asperger syndrome is not officially considered a separate disorder in US, but instead it is now part of the autism spectrum disorder (ASD). However, many doctors still use this term. The World Health Organization International Classification of Diseases, (ICD-11) which is used in other countries throughout the world still uses Asperger syndrome as a subtype of ASD.

MalaCards based summary : Asperger Syndrome, also known as asperger's disease, is related to autism and autism spectrum disorder. An important gene associated with Asperger Syndrome is ASPG2 (Asperger Syndrome, Susceptibility To, 2), and among its related pathways/superpathways are Cell adhesion molecules (CAMs) and Transmission across Chemical Synapses. The drugs Dopamine and Risperidone have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and eye, and related phenotypes are behavior/neurological and endocrine/exocrine gland

Disease Ontology : 12 An autism spectrum disorder that is characterized by significant difficulties in social interaction, along with restricted and repetitive patterns of behavior and interests. It differs from other autism spectrum disorders by its relative preservation of linguistic and cognitive development.

NINDS : 54 Asperger syndrome (AS) is a developmental disorder.  It is an autism spectrum disorder (ASD), one of a distinct group of neurological conditions characterized by a greater or lesser degree of impairment in language and communication skills, as well as repetitive or restrictive patterns of thought and behavior.  Other ASDs include:  classic autism, Rett syndrome, childhood disintegrative disorder, and pervasive developmental disorder not otherwise specified (usually referred to as PDD-NOS). Unlike children with autism, children with AS retain their early language skills. The most distinguishing symptom of AS is a child’s obsessive interest in a single object or topic to the exclusion of any other.  Children with AS want to know everything about their topic of interest and their conversations with others will be about little else.  Their expertise, high level of vocabulary, and formal speech patterns make them seem like little professors.  Other characteristics of AS include repetitive routines or rituals; peculiarities in speech and language; socially and emotionally inappropriate behavior and the inability to interact successfully with peers; problems with non-verbal communication; and clumsy and uncoordinated motor movements. Children with AS are isolated because of their poor social skills and narrow interests.  They may approach other people, but make normal conversation impossible by inappropriate or eccentric behavior, or by wanting only to talk about their singular interest.    Children with AS usually have a history of developmental delays in motor skills such as pedaling a bike, catching a ball, or climbing outdoor play equipment.   They are often awkward and poorly coordinated with a walk that can appear either stilted or bouncy. 

Wikipedia : 76 Asperger syndrome (AS), also known as Asperger''s, is a developmental disorder characterized by... more...

Related Diseases for Asperger Syndrome

Diseases in the Asperger Syndrome family:

Asperger Syndrome 2 Asperger Syndrome 1
Asperger Syndrome 3 Asperger Syndrome 4

Diseases related to Asperger Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 autism 31.8 AVPR1A DISC1 GABRB3 MECP2 NLGN3 NLGN4X
2 autism spectrum disorder 31.7 AVPR1A GABRB3 MECP2 NLGN3 NLGN4X OXTR
3 obsessive-compulsive disorder 30.2 OXTR SGCE SLC6A4
4 psychotic disorder 29.8 DISC1 GABRB3 SHANK3 SLC6A4
5 asperger syndrome, x-linked 1 12.5
6 asperger syndrome, x-linked 2 12.5
7 asperger syndrome 2 12.5
8 asperger syndrome 3 12.5
9 asperger syndrome 1 12.4
10 asperger syndrome 4 12.4
11 autism x-linked 1 11.1
12 autism x-linked 2 11.1
13 autism x-linked 3 11.1
14 autism x-linked 4 11.1
15 autism x-linked 5 11.1
16 autism x-linked 6 11.1
17 autism 5 11.1
18 autism 8 11.1
19 autism 3 11.1
20 autism 6 11.1
21 autism 7 11.1
22 autism 11 11.1
23 autism 12 11.1
24 autism 13 11.1
25 autism 9 11.1
26 autism 10 11.1
27 autism 15 11.1
28 autism 16 11.1
29 autism 17 11.1
30 autism 18 11.1
31 anxiety 10.4
32 schizophrenia 10.3
33 learning disability 10.2
34 attention deficit-hyperactivity disorder 10.2
35 childhood disintegrative disease 10.2 GABRB3 SHANK3
36 depression 10.1
37 specific developmental disorder 10.1 MECP2 SHANK3 SLC6A4
38 cognitive function 1, social 10.1
39 personality disorder 10.1
40 prosopagnosia 10.1
41 dysphasia, familial developmental 10.0
42 anorexia nervosa 10.0
43 atypical autism 10.0
44 specific language impairment 10.0
45 gender identity disorder 10.0
46 conduct disorder 10.0
47 myotonic dystrophy 10.0
48 myotonia atrophica 10.0
49 acth-independent macronodular adrenal hyperplasia 10.0 AVPR1A AVPR1B
50 disease of mental health 10.0 DISC1 MECP2 OXTR SHANK3 SLC6A4

Graphical network of the top 20 diseases related to Asperger Syndrome:



Diseases related to Asperger Syndrome

Symptoms & Phenotypes for Asperger Syndrome

MGI Mouse Phenotypes related to Asperger Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.07 AVPR1A AVPR1B CYP11B1 DISC1 GABRB3 MECP2
2 endocrine/exocrine gland MP:0005379 9.76 ARNT2 AVPR1A AVPR1B CYP11B1 MECP2 OXTR
3 homeostasis/metabolism MP:0005376 9.7 ARNT2 AVPR1A AVPR1B CYP11B1 DISC1 FH
4 nervous system MP:0003631 9.4 ARNT2 AVPR1A AVPR1B DISC1 GABRB3 MECP2

Drugs & Therapeutics for Asperger Syndrome

Drugs for Asperger Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 103)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2,Not Applicable 51-61-6, 62-31-7 681
2
Risperidone Approved, Investigational Phase 4,Phase 3,Not Applicable 106266-06-2 5073
3
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
4
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
5
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
6
Choline Approved, Nutraceutical Phase 4 62-49-7 305
7
Creatine Approved, Investigational, Nutraceutical Phase 4 57-00-1 586
8 Immunologic Factors Phase 4
9 Immunoglobulins Phase 4
10 Immunoglobulins, Intravenous Phase 4
11 gamma-Globulins Phase 4
12 Antibodies Phase 4
13 Rho(D) Immune Globulin Phase 4
14 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
15 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
16 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Not Applicable
17 Tranquilizing Agents Phase 4,Phase 3,Phase 2,Not Applicable
18 Serotonin Agents Phase 4,Phase 3,Phase 2,Not Applicable
19 Serotonin Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
20 Dopamine Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
21 Antipsychotic Agents Phase 4,Phase 3,Phase 2,Not Applicable
22 Dopamine Agents Phase 4,Phase 3,Phase 2,Not Applicable
23 Antidepressive Agents Phase 4,Phase 3,Phase 2
24 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2
25 Serotonin Uptake Inhibitors Phase 4,Phase 2
26 Adrenergic Agents Phase 4,Phase 3,Phase 2
27 Atomoxetine Hydrochloride Phase 4,Phase 3
28 Dopamine Uptake Inhibitors Phase 4
29 Central Nervous System Stimulants Phase 4
30 Antihypertensive Agents Phase 4
31 Adrenergic alpha-Agonists Phase 4
32 Adrenergic alpha-2 Receptor Agonists Phase 4
33 Adrenergic Agonists Phase 4
34
Serotonin Investigational, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 50-67-9 5202
35
Phosphocreatine Nutraceutical Phase 4 67-07-2 587
36
Mirtazapine Approved Phase 3 61337-67-5, 85650-52-8 4205
37
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
38
Mianserin Approved, Investigational Phase 3 24219-97-4 4184
39
Cycloserine Approved Phase 3 68-41-7 6234 401
40 Antidepressive Agents, Second-Generation Phase 3,Phase 2
41 Antidepressive Agents, Tricyclic Phase 3
42
Histamine Phosphate Phase 3 51-74-1 65513
43 Adrenergic alpha-Antagonists Phase 3,Phase 2
44 Adrenergic Antagonists Phase 3,Phase 2
45 Histamine H1 Antagonists Phase 3
46 Histamine Antagonists Phase 3
47 Antitubercular Agents Phase 3
48 Antimetabolites Phase 3
49 Anti-Bacterial Agents Phase 3
50 Antibiotics, Antitubercular Phase 3

Interventional clinical trials:

(show top 50) (show all 91)
# Name Status NCT ID Phase Drugs
1 An Open-Label Study to Evaluate the Efficacy of High-Dose Gammaplex in Children on the Autism Spectrum Unknown status NCT02199925 Phase 4 Gammaplex 5%
2 Janssen Asperger's MRS (Magnetic Resonance Spectroscopy Risperidone Study Completed NCT00352196 Phase 4 Risperidone
3 Milnacipran in Autism and the Functional Locus Coeruleus and Noradrenergic Model of Autism Completed NCT01337700 Phase 4 Milnacipran;Placebo
4 Atomoxetine, Placebo and Parent Management Training in Autism Completed NCT00844753 Phase 4 atomoxetine;Placebo
5 Methylphenidate ER Liquid Formulation in Adults With ASD and ADHD Completed NCT02096952 Phase 4 Methylphenidate extended-release liquid formulation
6 Guanfacine for the Treatment of Hyperactivity in Pervasive Developmental Disorder Completed NCT01238575 Phase 4 extended-release guanfacine
7 Mirtazapine Treatment of Anxiety in Children and Adolescents With Pervasive Developmental Disorders Completed NCT01302964 Phase 3 Placebo;Mirtazapine
8 Effectiveness of Atomoxetine in Treating ADHD Symptoms in Children and Adolescents With Autism Completed NCT00498173 Phase 3 Atomoxetine;Placebo
9 D-Cycloserine and Social Skills Training in Autism Spectrum Disorders Completed NCT01086475 Phase 3 D-cycloserine;Placebo
10 Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders Completed NCT01178385 Phase 2, Phase 3
11 A Study of the Effectiveness and Safety of Risperidone Versus Placebo in the Treatment of Children With Autistic Disorder and Other Pervasive Developmental Disorders (PDD) Completed NCT00261508 Phase 3 risperidone
12 Psychotherapy for Anxiety in Children With Autism Spectrum Disorder Active, not recruiting NCT02028247 Phase 3
13 A Study of Pediatric Participants With Attention Deficit/Hyperactivity Disorder Terminated NCT00965419 Phase 2, Phase 3 Edivoxetine
14 An Open-Label Safety Study of Memantine in Pediatric Patients With Autism, Asperger's Disorder, or Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) Completed NCT01592786 Phase 2 Memantine Hydrochloride (HCl)
15 Withdrawal Study of Memantine in Pediatric Patients With Autism, Asperger's Disorder, or Pervasive Developmental Disorder Not Otherwise Specified Previously Treated With Memantine Completed NCT01592747 Phase 2 Memantine Hydrochloride (HCl);Memantine Hydrochloride (HCl);Placebo capsules
16 CBT for Comorbid Anxiety Disorders in Children With Autism, Asperger Syndrome, or PDD-NOS Completed NCT00280670 Phase 2
17 The Development of Autistic Children Based on Mothers´Response in Autism Behavior Checklist Completed NCT00725556 Phase 1, Phase 2
18 Cognitive Behavioral Therapy (CBT) for Anxiety Disorders in Autism: Adapting Treatment for Adolescents Completed NCT01177969 Phase 1, Phase 2
19 A Study of Aripiprazole in Children and Adolescents With Aspergers and Pervasive Developmental Disorder. Completed NCT00198055 Phase 2 aripiprazole
20 A Study of Oral N-Acetylcysteine in Children With Autism Spectrum Disorders Completed NCT00453180 Phase 2 N-acetylcysteine;Placebo
21 Study of Aripiprazole to Treat Children and Adolescents With Autism Completed NCT00619190 Phase 2 aripiprazole
22 Cholesterol in ASD: Characterization and Treatment Completed NCT00965068 Phase 1, Phase 2
23 An Open-Label Trial of Aripiprazole in Autism Spectrum Disorders Completed NCT00308074 Phase 2 Aripiprazole
24 Omega-3 Fatty Acids For Treatment Of Young Children With Autism (OMG) Completed NCT01248728 Phase 2
25 Study of Arbaclofen for the Treatment of Social Withdrawal in Subjects With Autism Spectrum Disorders Completed NCT01288716 Phase 2 Arbaclofen
26 Riluzole to Treat Child and Adolescent Obsessive-Compulsive Disorder With or Without Autism Spectrum Disorders Completed NCT00251303 Phase 2 Riluzole;Placebo
27 My Scrivener® - Measuring Effectiveness and Dose Response in Children Completed NCT00919906 Phase 1, Phase 2
28 Study of Lurasidone in Treating Antipsychotic Naive or Quasi-Naive Children and Adolescents Completed NCT01731119 Phase 2 Latuda©
29 Citalopram for Children With Autism and Repetitive Behavior (STAART Study 1) Completed NCT00086645 Phase 2 citalopram hydrobromide
30 Essential Oils for Enhancing QOL in ASD Completed NCT02543203 Phase 2
31 Safety Study of Memantine in Pediatric Patients With Autism, Asperger's Disorder or Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) Terminated NCT01592773 Phase 2 Memantine Hydrochloride (HCl)
32 Transcranial Magnetic Stimulation for Evaluation and Treatment of Repetetive Behaviors in Autism Terminated NCT01983189 Phase 2
33 Deep rTMS (Repetitive Transcranial Magnetic Stimulation)for Treatment of Autism Symptoms in Children. Terminated NCT01388179 Phase 2
34 A Folinic Acid Intervention for Autism Spectrum Disorders Terminated NCT01602016 Phase 2 Folinic Acid and placebo;Folinic Acid
35 Mercury Chelation to Treat Autism Withdrawn NCT00376194 Phase 2 DMSA
36 Cognitive-Behavioral Therapy for Children With High-Functioning Autism Spectrum Disorder and Anxiety Completed NCT01187784 Phase 1
37 Evaluation of the French Version of Screening Questionnaires for Autism and Asperger Syndrome: AQ, EQ and SQ Unknown status NCT00505830
38 Adolescent Social Skills Training Program Unknown status NCT01031823 Not Applicable
39 A Prospective Observational Study of Family-based Interventions for Children With Neuropsychiatric and/or Psychiatric Disorders Unknown status NCT02250339
40 The Multi-Media Social Skills Project for Adults Unknown status NCT02995564 Not Applicable
41 Replication of the The Multi-Media Social Skills Project for Adolescents With Autism Spectrum Disorders Unknown status NCT01836965 Not Applicable
42 A Longitudinal Follow-up Imaging Study on Children and Adolescents With Autism Spectrum Disorder Unknown status NCT02719067
43 ASD-specific Induced Pluripotent Stem Cells for Disease Modeling Unknown status NCT02720939
44 A Salivary miRNA Diagnostic Test for Autism Unknown status NCT02832557
45 Investigating Neuroimaging Endophenotypes for Autism Spectrum Disorder Unknown status NCT02720588
46 A Non-Drug Study on the Relationship Between Exploratory Biomarkers and Functional Dimensions in Individuals With Autistic Disorder or Asperger's Syndrome Completed NCT01669889
47 The Use of rTMS to Improve Theory of Mind Among Adults With Autism and Asperger's Disorder Completed NCT00808782 Not Applicable
48 Validation of the French Adaptation of the RAADS-R Scale : Scale of Asperger Syndrome Diagnosis Completed NCT02826148 Not Applicable
49 Psychometric Studies of the Chinese Versions of the SRS, CAST, and AQ Completed NCT01247662
50 Portable Visual Guidance System Phase II Completed NCT00848874 Not Applicable

Search NIH Clinical Center for Asperger Syndrome

Cochrane evidence based reviews: asperger syndrome

Genetic Tests for Asperger Syndrome

Genetic tests related to Asperger Syndrome:

# Genetic test Affiliating Genes
1 Asperger's Disease 29

Anatomical Context for Asperger Syndrome

MalaCards organs/tissues related to Asperger Syndrome:

41
Testes, Brain, Eye, Amygdala, Cortex, Temporal Lobe, Breast

Publications for Asperger Syndrome

Articles related to Asperger Syndrome:

(show top 50) (show all 495)
# Title Authors Year
1
Age-moderating effect in prepotent response inhibition in boys with Asperger syndrome: a 2.5A years longitudinal study. ( 29942979 )
2018
2
Impaired detection and differentiation of briefly presented facial emotions in adults with high-functioning autism and asperger syndrome. ( 29477010 )
2018
3
Subtyping the Autism Spectrum Disorder: Comparison of Children with High Functioning Autism and Asperger Syndrome. ( 30043350 )
2018
4
Analysis of Asperger Syndrome Using Genetic-Evolutionary Random Support Vector Machine Cluster. ( 30524309 )
2018
5
A Case of Asperger Syndrome With Comorbidity of Posttraumatic Stress Disorder and Selective Mutism: Significant Remission With the Combination of Aripiprazole and Eye Movement Desensitization and Reprocessing. ( 27977468 )
2017
6
Behavioral, Cognitive and Neural Markers of Asperger Syndrome. ( 29167722 )
2017
7
Asperger syndrome and schizophrenia: I9eurodevelopmental continuum or separated clinical entities? ( 28686564 )
2017
8
Role of Two Types of Syntactic Embedding in Belief Attribution in Adults with or without Asperger Syndrome. ( 28553246 )
2017
9
Asperger syndrome and early-onset schizophrenia associated with a novel MECP2 deleterious missense variant. ( 28230711 )
2017
10
The effect of methylphenidate on anxiety and depression symptoms in patients with Asperger syndrome and comorbid attention deficit/hyperactivity disorder. ( 28368900 )
2017
11
Family functioning, parenting stress and quality of life in mothers and fathers of Polish children with high functioning autism or Asperger syndrome. ( 29036188 )
2017
12
Economic Evaluation Alongside a Randomized Controlled Crossover Trial of Modified Group Cognitive-Behavioral Therapy for Anxiety Compared to Treatment-as-Usual in Adults With Asperger Syndrome. ( 30288430 )
2017
13
From High Intellectual Potential to Asperger Syndrome: Evidence for Differences and a Fundamental Overlap-A Systematic Review. ( 27812341 )
2016
14
Romantic Relationships and Relationship Satisfaction Among Adults With Asperger Syndrome and High-Functioning Autism. ( 27196958 )
2016
15
The People with Asperger syndrome and anxiety disorders (PAsSA) trial: a pilot multicentre, single-blind randomised trial of group cognitive-behavioural therapy. ( 27703772 )
2016
16
Exploratory Study of Childbearing Experiences of Women With Asperger Syndrome. ( 26902438 )
2016
17
Neuroanatomical Markers of Neurological Soft Signs in Recent-Onset Schizophrenia and Asperger-Syndrome. ( 26708327 )
2016
18
Age-related differences in inhibitory control and memory updating in boys with Asperger syndrome. ( 28025692 )
2016
19
Effects of multisensory yoga on behavior in a male child with Apert and Asperger syndrome. ( 26865777 )
2016
20
Asperger syndrome in males over two decades: Quality of life in relation to diagnostic stability and psychiatric comorbidity. ( 27233289 )
2016
21
Asperger syndrome in childhood - personality dimensions in adult life: temperament, character and outcome trajectories. ( 27703778 )
2016
22
Do Adults with High Functioning Autism or Asperger Syndrome Differ in Empathy and Emotion Recognition? ( 26883645 )
2016
23
Asperger Syndrome and Schizophrenia: A Comparative Neuropsychological Study. ( 26936160 )
2016
24
Crohn's Disease and Asperger Syndrome: Not Just a Coincidence? ( 27104829 )
2016
25
The Hyper-Modular Associative Mind: A Computational Analysis of Associative Responses of Persons with Asperger Syndrome. ( 29924527 )
2016
26
Impaired social cognition processes in Asperger syndrome and anorexia nervosa. In search for endophenotypes of social cognition. ( 27556112 )
2016
27
The Occupational Transition Process to Upper Secondary School, Further Education and/or Work in Sweden: As Described by Young Adults with Asperger Syndrome and Attention Deficit Hyperactivity Disorder. ( 28005233 )
2016
28
Evaluation of Asperger Syndrome in Youth Presenting to a Gender Dysphoria Clinic. ( 26651183 )
2015
29
Beyond childhood: psychiatric comorbidities and social background of adults with Asperger syndrome. ( 25751431 )
2015
30
Genetic variant rs17225178 in the ARNT2 gene is associated with Asperger Syndrome. ( 25745553 )
2015
31
Asperger syndrome in India: findings from a case-series with respect to clinical profile and comorbidity. ( 25969609 )
2015
32
Boys with Asperger Syndrome Grow Up: Psychiatric and Neurodevelopmental Disorders 20A Years After Initial Diagnosis. ( 26210519 )
2015
33
3p22.1p21.31 microdeletion identifies CCK as Asperger syndrome candidate gene and shows the way for therapeutic strategies in chromosome imbalances. ( 26523151 )
2015
34
Early-onset anorexia nervosa in girls with Asperger syndrome. ( 26170676 )
2015
35
A Pooled Genome-Wide Association Study of Asperger Syndrome. ( 26176695 )
2015
36
A Concise History of Asperger Syndrome: The Short Reign of a Troublesome Diagnosis. ( 26834663 )
2015
37
Constrained spherical deconvolution-based tractography and tract-based spatial statistics show abnormal microstructural organization in Asperger syndrome. ( 25874076 )
2015
38
Correlation between chromatic sensitivity and higher order color vision functions in Asperger Syndrome but not in high functioning autism. ( 26325950 )
2015
39
Late diagnosis of Asperger syndrome in Croatia - a low-income country. ( 26609658 )
2015
40
The Puberty Video for Boys with Asperger Syndrome (and Autism Spectrum Disorder: Level 1) DVD $25.00, 48A Minutes and Managing Puberty, Social Challenges, and (Almost) Everything: A Video Guide for Girls: DVD, $25.00, 80 Minutes; Coulter Video (http://coultervideo.com). ( 25432100 )
2015
41
Repetition, response mobilization, and face: Analysis of group interactions with a 19-year-old with Asperger syndrome. ( 26026646 )
2015
42
Substance use disorder in Asperger syndrome: An investigation into the development and maintenance of substance use disorder by individuals with a diagnosis of Asperger syndrome. ( 26187185 )
2015
43
Incidental diagnosis of HLRCC following investigation for Asperger Syndrome: actionable and actioned. ( 26275867 )
2015
44
Group training in interpersonal problem-solving skills for workplace adaptation of adolescents and adults with Asperger syndrome: A preliminary study. ( 24569569 )
2014
45
Gaze and visual search strategies of children with Asperger syndrome/high functioning autism viewing a magic trick. ( 24866104 )
2014
46
Atypical prosody in Asperger syndrome: perceptual and acoustic measurements. ( 24590408 )
2014
47
I Collect Therefore I am-Autonoetic Consciousness and Hoarding in Asperger Syndrome. ( 24615808 )
2014
48
Asperger syndrome and schizophrenia: Overlap of self-reported autistic traits using the Autism-spectrum Quotient (AQ). ( 25389915 )
2014
49
History of suicide attempts in adults with Asperger syndrome. ( 25113892 )
2014
50
Piloting the use of experience sampling method to investigate the everyday social experiences of children with Asperger syndrome/high functioning autism. ( 24840290 )
2014

Variations for Asperger Syndrome

Expression for Asperger Syndrome

Search GEO for disease gene expression data for Asperger Syndrome.

Pathways for Asperger Syndrome

Pathways related to Asperger Syndrome according to KEGG:

37
# Name Kegg Source Accession
1 Cell adhesion molecules (CAMs) hsa04514

Pathways related to Asperger Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.41 GABRB3 NLGN3 NLGN4X SHANK3 SLC6A4
2 11.46 MECP2 SHANK3 SLC25A12 WFS1
3
Show member pathways
11.25 NLGN3 NLGN4X SHANK3

GO Terms for Asperger Syndrome

Cellular components related to Asperger Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 postsynaptic membrane GO:0045211 9.62 DISC1 GABRB3 NLGN4X SHANK3
2 integral component of plasma membrane GO:0005887 9.56 AVPR1A AVPR1B GABRB3 NLGN3 NLGN4X OXTR
3 presynapse GO:0098793 9.54 NLGN3 NLGN4X SLC6A4
4 excitatory synapse GO:0060076 9.4 NLGN3 NLGN4X
5 spanning component of membrane GO:0089717 9.26 NLGN3 NLGN4X
6 asymmetric, glutamatergic, excitatory synapse GO:0098985 9.16 NLGN3 NLGN4X
7 symmetric, GABA-ergic, inhibitory synapse GO:0098983 8.62 NLGN3 NLGN4X

Biological processes related to Asperger Syndrome according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 9.83 AVPR1A AVPR1B OXTR
2 negative regulation of neuron apoptotic process GO:0043524 9.82 GABRB3 MECP2 WFS1
3 response to estradiol GO:0032355 9.79 ARNT2 OXTR SLC6A4
4 memory GO:0007613 9.71 MECP2 OXTR SHANK3 SLC6A4
5 positive regulation of synapse assembly GO:0051965 9.7 MECP2 NLGN3 OXTR
6 synapse assembly GO:0007416 9.69 MECP2 NLGN3 SHANK3
7 long-term synaptic potentiation GO:0060291 9.67 MECP2 NLGN3 SHANK3
8 telencephalon development GO:0021537 9.65 AVPR1A OXTR
9 positive regulation of excitatory postsynaptic potential GO:2000463 9.65 NLGN3 SHANK3
10 positive regulation of vasoconstriction GO:0045907 9.65 AVPR1A AVPR1B OXTR
11 regulation of AMPA receptor activity GO:2000311 9.64 NLGN3 SHANK3
12 positive regulation of blood pressure GO:0045777 9.63 AVPR1A OXTR
13 brain morphogenesis GO:0048854 9.63 SHANK3 SLC6A4
14 adult behavior GO:0030534 9.63 NLGN3 NLGN4X SHANK3
15 regulation of dendritic spine morphogenesis GO:0061001 9.62 NLGN3 SHANK3
16 learning GO:0007612 9.62 MECP2 NLGN3 NLGN4X SHANK3
17 neuron cell-cell adhesion GO:0007158 9.61 NLGN3 NLGN4X
18 presynapse assembly GO:0099054 9.61 NLGN3 NLGN4X
19 positive regulation of synaptic transmission, glutamatergic GO:0051968 9.61 NLGN3 OXTR SHANK3
20 maternal behavior GO:0042711 9.6 AVPR1A OXTR
21 regulation of respiratory gaseous exchange by neurological system process GO:0002087 9.59 MECP2 NLGN3
22 presynaptic membrane assembly GO:0097105 9.58 NLGN3 NLGN4X
23 regulation of long-term synaptic potentiation GO:1900271 9.58 NLGN3 SHANK3
24 inhibitory postsynaptic potential GO:0060080 9.57 GABRB3 NLGN3
25 negative regulation of excitatory postsynaptic potential GO:0090394 9.56 NLGN3 NLGN4X
26 cellular response to hormone stimulus GO:0032870 9.56 AVPR1A AVPR1B CYP11B1 OXTR
27 postsynaptic membrane assembly GO:0097104 9.55 NLGN3 NLGN4X
28 positive regulation of AMPA receptor activity GO:2000969 9.54 NLGN3 SHANK3
29 vocalization behavior GO:0071625 9.54 NLGN3 NLGN4X SHANK3
30 regulation of systemic arterial blood pressure by vasopressin GO:0001992 9.33 AVPR1A AVPR1B OXTR
31 social behavior GO:0035176 9.17 AVPR1A MECP2 NLGN3 NLGN4X OXTR SHANK3
32 sperm ejaculation GO:0042713 9.13 AVPR1A OXTR SLC6A4

Molecular functions related to Asperger Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurexin family protein binding GO:0042043 9.16 NLGN3 NLGN4X
2 scaffold protein binding GO:0097110 9.13 NLGN3 NLGN4X SHANK3
3 vasopressin receptor activity GO:0005000 8.8 AVPR1A AVPR1B OXTR

Sources for Asperger Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
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54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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