ASPG1
MCID: ASP032
MIFTS: 21

Asperger Syndrome 1 (ASPG1)

Categories: Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Asperger Syndrome 1

MalaCards integrated aliases for Asperger Syndrome 1:

Name: Asperger Syndrome 1 58
Asperger Syndrome, Susceptibility to, 1 58 13 74
Asperger Syndrome Susceptibility 1 58
Aspg1 58

Characteristics:

OMIM:

58
Inheritance:
isolated cases
multifactorial

Miscellaneous:
onset in early childhood
genetic heterogeneity (see, e.g., )


HPO:

33
asperger syndrome 1:
Inheritance heterogeneous sporadic multifactorial inheritance
Onset and clinical course juvenile onset


Classifications:



External Ids:

OMIM 58 608638
MedGen 43 C1837646
UMLS 74 C1837646

Summaries for Asperger Syndrome 1

OMIM : 58 Asperger syndrome is considered to be a form of childhood autism (see, e.g., 209850). The DSM-IV (American Psychiatric Association, 1994) specifies several diagnostic criteria for Asperger syndrome, which has many of the same features as autism. In general, patients with Asperger syndrome and autism exhibit qualitative impairment in social interaction, as manifest by impairment in the use of nonverbal behaviors such as eye-to-eye gaze, facial expression, body postures, and gestures, failure to develop appropriate peer relationships, and lack of social sharing or reciprocity. Patients also exhibit restricted, repetitive and stereotyped patterns of behavior, interests, and activities, including abnormal preoccupation with certain activities and inflexible adherence to routines or rituals. Asperger syndrome is primarily distinguished from autism by the higher cognitive abilities and a more normal and timely development of language and communicative phrases. Gillberg et al. (2001) described the development of the Asperger syndrome (and high-functioning autism) Diagnostic Interview (ASDI), which they claimed has a strong validity in the diagnosis of the disorder. (608638)

MalaCards based summary : Asperger Syndrome 1, also known as asperger syndrome, susceptibility to, 1, is related to asperger syndrome and autism. An important gene associated with Asperger Syndrome 1 is ASPG1 (Asperger Syndrome, Susceptibility To, 1). Affiliated tissues include eye, and related phenotypes are stereotypy and autism

Related Diseases for Asperger Syndrome 1

Diseases in the Asperger Syndrome family:

Asperger Syndrome 2 Asperger Syndrome 1
Asperger Syndrome 3 Asperger Syndrome 4

Diseases related to Asperger Syndrome 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)
# Related Disease Score Top Affiliating Genes
1 asperger syndrome 11.3
2 autism 10.9
3 autism x-linked 1 10.9
4 autism x-linked 2 10.9
5 autism x-linked 3 10.9
6 autism x-linked 4 10.9
7 autism x-linked 5 10.9
8 autism x-linked 6 10.9
9 autism 8 10.9
10 autism 3 10.9
11 asperger syndrome 2 10.9
12 asperger syndrome 3 10.9
13 autism 6 10.9
14 asperger syndrome 4 10.9
15 autism 7 10.9
16 autism 11 10.9
17 autism 12 10.9
18 autism 13 10.9
19 autism 9 10.9
20 autism 10 10.9
21 autism 15 10.9
22 autism 16 10.9
23 autism 17 10.9
24 autism 18 10.9

Graphical network of the top 20 diseases related to Asperger Syndrome 1:



Diseases related to Asperger Syndrome 1

Symptoms & Phenotypes for Asperger Syndrome 1

Human phenotypes related to Asperger Syndrome 1:

33 (show all 8)
# Description HPO Frequency HPO Source Accession
1 stereotypy 33 HP:0000733
2 autism 33 HP:0000717
3 impaired use of nonverbal behaviors 33 HP:0000758
4 restrictive behavior 33 HP:0000723
5 autism with high cognitive abilities 33 HP:0000753
6 impaired ability to form peer relationships 33 HP:0000728
7 lack of spontaneous play 33 HP:0000721
8 inflexible adherence to routines or rituals 33 HP:0000732

Symptoms via clinical synopsis from OMIM:

58
Neurologic Behavioral Psychiatric Manifestations:
impaired social interactions
impaired use of nonverbal behaviors, such as eye-to-eye gaze, facial expression, body posture, and gestures
impaired ability to form peer relationships
lack of spontaneous play
restrictive behavior, interests, and activities
more
Neurologic Central Nervous System:
normal, timely language development

Clinical features from OMIM:

608638

Drugs & Therapeutics for Asperger Syndrome 1

Search Clinical Trials , NIH Clinical Center for Asperger Syndrome 1

Genetic Tests for Asperger Syndrome 1

Anatomical Context for Asperger Syndrome 1

MalaCards organs/tissues related to Asperger Syndrome 1:

42
Eye

Publications for Asperger Syndrome 1

Variations for Asperger Syndrome 1

Expression for Asperger Syndrome 1

Search GEO for disease gene expression data for Asperger Syndrome 1.

Pathways for Asperger Syndrome 1

GO Terms for Asperger Syndrome 1

Sources for Asperger Syndrome 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....