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MCID: ASP006
MIFTS: 66

Aspergillosis

Categories: Genetic diseases, Immune diseases, Infectious diseases, Rare diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Aspergillosis

About this section

MalaCards integrated aliases for Aspergillosis:

Name: Aspergillosis 57 12 76 53 59 55 43 3 44 15 73
Aspergillosis, Susceptibility to 57 29 13 6 40
Infection Due to Aspergillus 12

Characteristics:

Orphanet epidemiological data:

59
aspergillosis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Infectious diseases
Anatomical: Immune diseases Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 33 34
Orphanet: 59  
Rare infectious diseases


External Ids:

OMIM 57 614079
Disease Ontology 12 DOID:13564
ICD10 33 B44 B44.9
ICD9CM 35 117.3
MeSH 44 D001228
NCIt 50 C2886
SNOMED-CT 68 65553006
Orphanet 59 ORPHA1163
MESH via Orphanet 45 D001228
UMLS via Orphanet 74 C0004030
ICD10 via Orphanet 34 B44.0 B44.1 B44.2 more
UMLS 73 C0004030
Sources

Summaries for Aspergillosis

About this section
NIH Rare Diseases : 53 Aspergillosis is an infection, growth, or allergic response caused by the Aspergillus fungus. There are several different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue. Another kind of aspergillosis is invasive aspergillosis. This infection usually affects people with weakened immune systems due to cancer, AIDS, leukemia, organ transplantation, chemotherapy, or other conditions or events that reduce the number of normal white blood cells. In this condition, the fungus invades and damages tissues in the body. Invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain).Aspergilloma, a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess, is a third kind of aspergillosis. This type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells. The fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas.

MalaCards based summary : Aspergillosis, also known as aspergillosis, susceptibility to, is related to invasive aspergillosis and allergic bronchopulmonary aspergillosis, and has symptoms including fever and pruritus. An important gene associated with Aspergillosis is CLEC7A (C-Type Lectin Domain Containing 7A), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Voriconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and kidney, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney, heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system.

OMIM : 57 Aspergillus species are ubiquitous in nature and cause a wide spectrum of diseases, including saprophytic colonization of existing cavities (aspergilloma), allergic asthma, hypersensitivity pneumonitis, allergic bronchopulmonary aspergillosis, and disseminated disease associated with high mortality rates in patients with hematologic malignancies and recipients of solid organs and stem cell transplantations. Immunocompetent and nonatopic individuals are relatively resistant to infection, and disease occurs in the setting of host damage. Association of persistent inflammation with intractable infection is common in nonneutropenic patients after hematopoietic stem cell transplantation, as well as in allergic fungal diseases. The pathophysiology underlying Aspergillus infection highlights the bipolar nature of the inflammatory process in infection, in which early inflammation prevents or limits infection, but an uncontrolled response may oppose disease eradication (summary by Cunha et al., 2010). For information on familial occurrence of allergic bronchopulmonary aspergillosis, see 103920. (614079)

MedlinePlus : 43 Aspergillosis is a disease caused by a fungus (or mold) called Aspergillus. The fungus is very common in both indoors and outdoors. Most people breathe in the spores of the fungus every day without being affected. But some people get the disease. It usually occurs in people with lung diseases or weakened immune systems. There are different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA). Symptoms of ABPA include wheezing and coughing. ABPA can affect healthy people but it is most common in people with asthma or cystic fibrosis. Another kind is invasive aspergillosis, which damages tissues in the body. It usually affects the lungs. Sometimes it can also cause infection in other organs and spread throughout the body. It affects people who have immune system problems, such as people who have had a transplant, are taking high doses of steroids, or getting chemotherapy for some cancers. Your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, CT scan of the lungs, and an examination of tissues for signs of the fungus. Treatment is with antifungal drugs. If you have ABPA, you may also take steroids. Centers for Disease Control and Prevention

CDC : 3 Healthcare providers: Aspergillus infections have been reported in patients with severe influenza. Click here to learn more.

Wikipedia : 76 Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus... more...

Sources

Related Diseases for Aspergillosis

About this section

Diseases in the Aspergillosis family:

Invasive Aspergillosis

Diseases related to Aspergillosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 524)
# Related Disease Score Top Affiliating Genes
1 invasive aspergillosis 33.5 CLEC7A IFNG MBL2 SFTPD TLR2 TLR4
2 allergic bronchopulmonary aspergillosis 33.4 CCL17 CFTR IL4 IL5 MBL2 SFTPA2
3 mucormycosis 30.9 CSF2 IFNG
4 cystic fibrosis 30.7 CFTR ELANE MBL2 SFTPD TLR4
5 chronic granulomatous disease 30.7 CSF2 IFNG TLR9
6 candidiasis 30.6 CLEC7A IFNG IL10 MBL2
7 hematopoietic stem cell transplantation 30.2 CLEC7A IFNG IL10 TNF
8 rhinitis 30.1 IL4 IL5 TLR9
9 cryptococcosis 30.1 IFNG IL4 MBL2 TLR9
10 bronchiectasis 29.9 CFTR ELANE MBL2 TLR2
11 endocarditis 29.9 IL10 TLR2 TNF
12 allergic rhinitis 29.9 IFNG IL10 IL4 IL5
13 graft-versus-host disease 29.8 IFNG IL10 TNF
14 cough variant asthma 29.8 IL4 IL5
15 farmer's lung 29.8 ELANE TNF
16 hyper ige syndrome 29.7 IFNG IL4 TLR4
17 aplastic anemia 29.7 CSF2 IFNG IL4 TNF
18 acquired immunodeficiency syndrome 29.7 CSF2 IFNG IL10 TNF
19 pulmonary disease, chronic obstructive 29.7 CFTR ELANE SFTPD TLR2 TNF
20 cutaneous t cell lymphoma 29.7 CCL17 IFNG IL4
21 systemic scleroderma 29.6 IFNG SFTPD TLR9
22 pneumocystosis 29.6 CLEC7A SFTPD TNF
23 respiratory failure 29.6 ELANE SFTPD TNF
24 bronchiolitis obliterans 29.6 IFNG IL10 TNF
25 eosinophilic pneumonia 29.6 CCL17 CSF2 IL5 SFTPD
26 legionellosis 29.6 TLR2 TLR4 TNF
27 septic arthritis 29.6 TLR2 TLR4 TLR9
28 pulmonary tuberculosis 29.6 IFNG IL10 IL4 MBL2 TLR2 TLR9
29 arthritis 29.6 CSF2 IFNG IL10 TNF
30 staphylococcal toxic shock syndrome 29.5 IFNG TNF
31 bacterial pneumonia 29.5 ELANE SFTPD TLR4 TLR9
32 microscopic polyangiitis 29.5 IL10 TNF
33 acute respiratory distress syndrome 29.5 ELANE SFTPD TNF
34 ulcerative colitis 29.5 IFNG IL10 TLR4 TNF
35 paranasal sinus disease 29.5 IFNG IL10 IL4 IL5
36 dermatitis 29.4 CCL17 IFNG IL4 IL5 TLR9
37 acute graft versus host disease 29.4 IFNG IL10 IL4 TNF
38 pulmonary eosinophilia 29.4 CCL17 IL4 IL5 SFTPD
39 hemophagocytic lymphohistiocytosis 29.4 IFNG IL10 TNF
40 osteomyelitis 29.4 IFNG IL10 TNF
41 aseptic meningitis 29.4 IFNG IL10 TNF
42 pyelonephritis 29.4 IL10 TLR4 TNF
43 acute pancreatitis 29.4 CFTR ELANE IL10
44 colitis 29.4 IFNG IL10 IL4 TLR4 TLR9 TNF
45 hypereosinophilic syndrome 29.4 CCL17 CSF2 IL4 IL5
46 pneumonia 29.3 ELANE IL10 IL5 MBL2 SFTPD TLR2
47 churg-strauss syndrome 29.3 CCL17 IL10 IL5 TNF
48 allergic asthma 29.3 CCL17 IFNG IL10 IL4 IL5
49 dengue hemorrhagic fever 29.3 CD209 IFNG IL10 TNF
50 chronic graft versus host disease 29.2 IFNG IL10 TNF

Comorbidity relations with Aspergillosis via Phenotypic Disease Network (PDN):


Bronchiectasis Bronchitis
Deficiency Anemia Heart Disease
Postinflammatory Pulmonary Fibrosis Respiratory Failure

Graphical network of the top 20 diseases related to Aspergillosis:



Diseases related to Aspergillosis
Sources

Symptoms & Phenotypes for Aspergillosis

About this section

Clinical features from OMIM:

614079

UMLS symptoms related to Aspergillosis:


fever, pruritus

MGI Mouse Phenotypes related to Aspergillosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.33 CCL17 CFTR CLEC7A CSF2 ELANE IFNG
2 homeostasis/metabolism MP:0005376 10.28 CFTR CLEC7A CSF2 ELANE IFNG IL10
3 immune system MP:0005387 10.28 CCL17 CFTR CLEC7A CSF2 ELANE IFNG
4 digestive/alimentary MP:0005381 10.18 CFTR CLEC7A IFNG IL10 IL4 IL5
5 mortality/aging MP:0010768 10.1 CFTR CLEC7A CSF2 ELANE IFNG IL10
6 liver/biliary system MP:0005370 9.97 CFTR IFNG IL10 IL4 IL5 TLR2
7 neoplasm MP:0002006 9.86 CSF2 ELANE IFNG IL10 IL5 TLR2
8 renal/urinary system MP:0005367 9.7 CSF2 IFNG IL4 MBL2 TLR2 TLR4
9 reproductive system MP:0005389 9.56 CFTR CSF2 IFNG IL10 IL4 IL5
10 respiratory system MP:0005388 9.36 CFTR CLEC7A CSF2 IFNG IL10 IL4
Sources

Drugs & Therapeutics for Aspergillosis

About this section

Drugs for Aspergillosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 163)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Voriconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137234-62-9 71616
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
3
Amphotericin B Approved, Investigational Phase 4,Phase 2,Phase 3 1397-89-3 5280965 14956
4
Caspofungin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 179463-17-3, 162808-62-0 468682 2826718
5
Itraconazole Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 84625-61-6 55283
6
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
7
Anidulafungin Approved, Investigational Phase 4,Phase 3,Phase 2 166663-25-8 166548
8
Micafungin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 235114-32-6 3081921 477468
9
Ritonavir Approved, Investigational Phase 4,Phase 3 155213-67-5 392622
10
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
11
Nevirapine Approved Phase 4 129618-40-2 4463
12
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 171228-49-2 147912
13
Prednisone Approved, Vet_approved Phase 4,Phase 1,Phase 2 53-03-2 5865
14
Mycophenolic acid Approved Phase 4,Phase 1 24280-93-1 446541
15
Omalizumab Approved, Investigational Phase 4 242138-07-4
16
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 50-14-6 5280793
17
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 1406-16-2
18
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 67-97-0 5280795 6221
19
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
20 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
21 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
22 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
23 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
24 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
25 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
26 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
28 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1
29 Liposomal amphotericin B Phase 4,Phase 2,Phase 3
30 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
31 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1
32 Echinocandins Phase 4,Phase 3,Phase 2,Phase 1
33 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Early Phase 1
34 Antitussive Agents Phase 4
35 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
36
Hydroxyitraconazole Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
37 Calciferol Phase 4,Phase 2,Phase 3,Not Applicable
38 Trace Elements Phase 4,Phase 2,Phase 3,Not Applicable
39 Micronutrients Phase 4,Phase 2,Phase 3,Not Applicable
40 Ergocalciferols Phase 4,Phase 2,Phase 3,Not Applicable
41 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3,Not Applicable
42 Vitamin D2 Phase 4,Phase 2,Phase 3,Not Applicable
43 Vitamins Phase 4,Phase 2,Phase 3,Not Applicable
44 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1
45 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 1
46 HIV Protease Inhibitors Phase 4,Phase 3
47 Anti-HIV Agents Phase 4,Phase 3
48 Cytochrome P-450 CYP3A Inducers Phase 4
49 Atazanavir Sulfate Phase 4
50 Reverse Transcriptase Inhibitors Phase 4

Interventional clinical trials:

(show top 50) (show all 192)
# Name Status NCT ID Phase Drugs
1 Voriconazole for IPA in Chinese Patients With COPD Unknown status NCT02234739 Phase 4 Voriconazole
2 Value of Amphotericin B Inhalation for Prophylaxis of Invasive Pulmonary Aspergillosis After Renal Transplantation Unknown status NCT00986713 Phase 4 Amphotericin B
3 Efficacy and Safety of Caspofungin for Invasive Pulmonary Aspergillosis Underlying Chronic Obstructive Pulmonary Disease Unknown status NCT01499433 Phase 4 caspofungin
4 Efficacy Of Itraconazole In Chronic Cavitary Pulmonary Aspergillosis Completed NCT01259336 Phase 4 Itraconazole;treatment in cavitary pulmonary aspergillosis
5 COMBISTRAT: AmBisome® in Combination With Caspofungin for the Treatment of Invasive Aspergillosis Completed NCT00334412 Phase 4 Ambisome;caspofungin
6 A Study To Assess The Anidulafungin And Voriconazole Concentration In Lung Following Intravenous Administration In Healthy Subjects Completed NCT00940017 Phase 4 anidulafungin and voriconazole
7 A Study of the Efficacy and Safety of Voriconazole for the Treatment of Fungal Infections Completed NCT00647907 Phase 4 Voriconazole
8 Pharmacokinetics of Micafungin in Patients of Intensive Care Units Completed NCT02164890 Phase 4
9 VITamine D Supplementation in RenAL Transplant Recipients - VITALE Completed NCT01431430 Phase 4 Cholecalciferol 100 000 UI;Cholecalciferol 12 000 UI
10 Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT) Completed NCT00552240 Phase 4 tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
11 Posaconazole for the Prevention of Influenza-associated Aspergillosis in Critically Ill Patients Recruiting NCT03378479 Phase 4 SOC +Posaconazole 18 MG/ML (milligram/milliliter)
12 CYP2C19 Genotype-Specific Dosing Plus TDM on Reaching Therapeutic Voriconazole Blood Levels Recruiting NCT03731169 Phase 4 Standard of Care
13 King's Invasive Aspergillosis Study II Active, not recruiting NCT02875743 Phase 4 Posaconazole
14 Posaconazole Pharmacokinetics in Patients Receiving Chemotherapy or Stem Cell Transplants Not yet recruiting NCT03717623 Phase 4 Posaconazole pharmacokinetics
15 Study to Test the Combination of Voriconazole and Anidulafungin in Patients Who Have, or Are Thought to Have, Invasive Aspergillosis and Who Are Unable to Take a Common Antifungal Therapy (Polyene) Terminated NCT00620074 Phase 4 voriconazole;anidulafungin
16 Post Marketing Study to Evaluate the Efficacy and Safety of Micafungin Treatment on Invasive Aspergillosis Terminated NCT02646774 Phase 4 Micafungin
17 An Exploratory Study to Assess Multiple Doses of Omalizumab in Patients With Cystic Fibrosis Complicated by Acute Bronchopulmonary Aspergillosis (ABPA) Terminated NCT00787917 Phase 4 Omalizumab;Placebo;Itraconazole
18 Post Marketing Study to Evaluate the Safety and Efficacy of Micafungin Against Fungal Infections Caused by Candida Spp or Aspergillus Spp Terminated NCT02646800 Phase 4 Micafungin
19 Comparison of 2 Antifungal Treatment (Empirical Versus Pre-Empirical) Strategies in Prolonged Neutropenia Terminated NCT00190463 Phase 4 Amphotericin B
20 Evaluation of Antifungal Prophylaxis on Graft-versus-host Disease (GVHD) Patients Terminated NCT01282879 Phase 4 Itraconazole
21 A Study to Evaluate the Effectiveness of Voriconazole + Micafungin Versus Voriconazole Alone for Invasive Aspergillosis Withdrawn NCT00423163 Phase 4 micafungin;voriconazole
22 Posaconazole as Salvage Therapy for Aspergillus Pulmonary Infection. Withdrawn NCT02020213 Phase 4 Posaconazole
23 Efficacy, Safety and Pharmacokinetics of SPK-843 in the Treatment of Pulmonary Mycosis Unknown status NCT01125644 Phase 3 SPK-843
24 Anidulafungin Plus Voriconazole Versus Voriconazole For The Treatment Of Invasive Aspergillosis Completed NCT00531479 Phase 3 voriconazole;anidulafungin;voriconazole
25 Voriconazole For Chronic Bronchopulmonary Aspergillosis Completed NCT00159822 Phase 2, Phase 3 Voriconazole
26 Inhalation of Liposomal Amphotericin B to Prevent Invasive Aspergillosis Completed NCT00263315 Phase 2, Phase 3 nebulised liposomal amphotericin B
27 A Multicentre Randomised Controlled Trial Comparing Two Strategies for the Diagnosis of Invasive Aspergillosis in High-risk Haematology Patients Completed NCT00163722 Phase 3
28 Trial on the Efficacy and Safety of Two Different Glucocorticoid Dose Regimens in Allergic Bronchopulmonary Aspergillosis Completed NCT00974766 Phase 2, Phase 3 Glucocorticoids;Glucocorticoids
29 A Safety & Effectiveness Study of Intravenous Anidulafungin With AmBisome® for Treatment of Invasive Aspergillosis (IA). Completed NCT00037206 Phase 2, Phase 3 Anidulafungin, VER002
30 A Study Evaluating Vitamin D in Allergic Bronchopulmonary Aspergillosis Complicating Asthma Completed NCT03133299 Phase 2, Phase 3 Glucocorticoids;Vitamin D
31 Voriconazole Versus Oral Steroids in Allergic Bronchopulmonary Aspergillosis Completed NCT01621321 Phase 2, Phase 3 Prednisolone;Voriconazole
32 Isavuconazole in the Treatment of Renally Impaired Aspergillosis and Rare Fungi Completed NCT00634049 Phase 3 isavuconazole
33 A Randomized Controlled Trial of Inhaled Amphotericin B for Maintaining Remission in Allergic Bronchopulmonary Aspergillosis Completed NCT01857479 Phase 2, Phase 3 Inhaled budesonide;Inhaled amphotericin
34 Voriconazole vs. Amphotericin B in the Treatment of Invasive Aspergillosis Completed NCT00001646 Phase 3 Voriconazole;Amphotericin B
35 Comparison of Voriconazole and Amphotericin B in Treating Patients With Aspergillosis Completed NCT00003031 Phase 3 amphotericin B deoxycholate;voriconazole
36 Isavuconazole (BAL8557) for Primary Treatment of Invasive Aspergillosis Completed NCT00412893 Phase 3 Isavuconazole;Voriconazole
37 Study Safety/Efficacy of AmBisome Loading Dose Regimen Versus Standard AmBisome Regimen for Initial Treatment Completed NCT00158730 Phase 3 AmBisome
38 Assessing the Safety and Efficacy of MK-5592 (Posaconazole) in Japanese Participants With Fungal Infection (MK-5592-101) Completed NCT02180165 Phase 3 Posaconazole;Voriconazole
39 To Determine Whether Galactomannan Test Will Help to Detect Fungal Infections Early and Hence Start Treatment Early Completed NCT00361517 Phase 3 Amphotericin-B deoxycholate
40 Monotherapy of Itraconazole Versus Prednisolone in Allergic Bronchopulmonary Aspergillosis Completed NCT01321827 Phase 2, Phase 3 Glucocorticoids;Itraconazole
41 A Clinical Study of MK0991 (Caspofungin) in Japanese Patients With Deep-seated Candida or Aspergillus Infections (0991-062)(COMPLETED) Completed NCT00717860 Phase 3 caspofungin acetate;Comparator: Micafungin sodium
42 An Open Label, Non-Comparative, Multicenter, Phase III Trial of the Efficacy, Safety and Toleration of Voriconazole in the Primary or Secondary Treatment of Invasive Fungal Infections Completed NCT00001810 Phase 3 Voriconazole
43 Comparing the Effectiveness of Fluconazole and a New Medicine (FK463) in Preventing Fungal Infections in Bone Marrow Transplant Patients Completed NCT00001937 Phase 3 FK463;Fluconazole
44 Open Label Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P00041) Completed NCT00034658 Phase 3 Posaconazole
45 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
46 Pharmacokinetic Profiles of Inhaled Lipid Complex Amphotericin B (Abelcet ®) Completed NCT00177684 Phase 3 Amphotericin B
47 Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P02095) Completed NCT00034632 Phase 3 Posaconazole oral suspension
48 A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection Completed NCT00784368 Phase 3 ITCZ Oral Solution;ITCZ-IV
49 An Open Label, Non-Comparative, Multicenter, Phase III Trial of the Efficacy, Safety and Toleration of Voriconazole in the Primary or Secondary Treatment of Invasive Fungal Infections Completed NCT00001757 Phase 3 Voriconazole
50 Interleukin-2 Plus Antiretroviral Therapy for HIV-Infected Patients With Low CD4+ Counts (SILCAAT Study) Completed NCT00013611 Phase 3 Proleukin

Search NIH Clinical Center for Aspergillosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: aspergillosis

Sources

Genetic Tests for Aspergillosis

About this section

Genetic tests related to Aspergillosis:

# Genetic test Affiliating Genes
1 Aspergillosis, Susceptibility to 29 CLEC7A
Sources

Anatomical Context for Aspergillosis

About this section

MalaCards organs/tissues related to Aspergillosis:

41
Lung, Testes, Kidney, Liver, Brain, Myeloid, Bone
Sources

Publications for Aspergillosis

About this section

Articles related to Aspergillosis:

(show top 50) (show all 2905)
# Title Authors Year
1
Allergic bronchopulmonary aspergillosis successfully treated with mepolizumab: Case report and review of the literature. ( 30533379 )
2019
2
Chronic pulmonary aspergillosis following pulmonary embolism. ( 30505676 )
2019
3
The diagnosis and treatment of invasive aspergillosis in Dutch haematology units facing a rapidly increasing prevalence of azole-resistance. A nationwide survey and rationale for the DB-MSG 002 study protocol. ( 29687483 )
2018
4
Spotlight on isavuconazole in the treatment of invasive aspergillosis and mucormycosis: design, development, and place in therapy. ( 29750016 )
2018
5
"Fleeting pulmonary infiltrates in allergic bronchopulmonary aspergillosis" Misdiagnosed as tuberculosis. ( 29900899 )
2018
6
National Jewish Health Classical Pulmonary Radiology Case Reports: Imaging Features of Allergic Bronchopulmonary Aspergillosis. ( 29878247 )
2018
7
Performance of serum (1,3)-A9-d-glucan screening for the diagnosis of invasive aspergillosis in neutropenic patients with haematological malignancies. ( 29693758 )
2018
8
Invasive pulmonary aspergillosis mimicking organizing pneumonia after mTOR inhibitor therapy: a case report. ( 29408183 )
2018
9
Cerebral aspergillosis: An emerging opportunistic infection in patients receiving ibrutinib for chronic lymphocytic leukemia? ( 29402474 )
2018
10
Omalizumab in allergic bronchopulmonary aspergillosis in patients with cystic fibrosis. ( 29950869 )
2018
11
Early-onset invasive aspergillosis and other fungal infections in patients treated with ibrutinib. ( 29437588 )
2018
12
Risk Factors and impact of Allergic Bronchopulmonary Aspergillosis in P. aeruginosa negative CF Patients. ( 29981532 )
2018
13
Prevalence of sensitization to Aspergillus flavus in patients with allergic bronchopulmonary aspergillosis. ( 29566248 )
2018
14
Subacute invasive aspergillosis associated with sorafenib therapy for hepatocellular carcinoma. ( 29370392 )
2018
15
Predicting Invasive Aspergillosis in Hematology Patients by Combining Clinical and Genetic Risk Factors with Early Diagnostic Biomarkers. ( 29118175 )
2018
16
How we approach combination antifungal therapy for invasive aspergillosis and mucormycosis in transplant recipients. ( 29975240 )
2018
17
Vitamin D levels in asthmatic patients with and without allergic bronchopulmonary aspergillosis. ( 29314357 )
2018
18
Chitinase Induction Prior to Caspofungin Treatment of Experimental Invasive Aspergillosis in Neutropenic Rats Does Not Enhance Survival. ( 29084744 )
2018
19
Cost-effectiveness analysis of interventions for prevention of invasive aspergillosis among leukemia patients during hospital construction activities. ( 29105850 )
2018
20
Receiver operating characteristic curve analysis of four Aspergillus-specific IgG assays for the diagnosis of chronic pulmonary aspergillosis. ( 29398462 )
2018
21
A Randomized Trial of Itraconazole vs Prednisolone in Acute-Stage Allergic Bronchopulmonary Aspergillosis Complicating Asthma. ( 29331473 )
2018
22
X-linked agammaglobulinemia complicated with pulmonary aspergillosis. ( 29356289 )
2018
23
Pentraxin3 in bronchoalveolar lavage fluid and plasma in non-neutropenic patients with pulmonary aspergillosis. ( 29964232 )
2018
24
Invasive mould disease in haematologic patients: comparison between fusariosis and aspergillosis. ( 29787890 )
2018
25
Clinical Characteristics of Fifty Patients with Allergic Bronchopulmonary Aspergillosis. ( 29692383 )
2018
26
Invasive aspergillosis in patients following umbilical cord blood transplant. ( 29795425 )
2018
27
Genetic deficiency of NOD2 confers resistance to invasive aspergillosis. ( 29980664 )
2018
28
Breakthrough invasive aspergillosis and diagnostic accuracy of serum galactomannan enzyme immune assay during acute myeloid leukemia induction chemotherapy with posaconazole prophylaxis. ( 29928481 )
2018
29
Galactomannan antigenemia as a biomarker for therapeutic response of invasive aspergillosis: implications for clinical trial design and patient care. ( 29897826 )
2018
30
Allergic bronchopulmonary aspergillosis presenting as nephrotic syndrome due to secondary amyloidosis: Case report and systematic review of the literature. ( 29970774 )
2018
31
Sinonasal aspergillosis: Outcome after topical treatment in dogs with cribriform plate lysis. ( 29957889 )
2018
32
Diagnostic Aspects of Veterinary and Human Aspergillosis. ( 29977229 )
2018
33
Multiple small bowel perforations due to invasive aspergillosis in a patient with acute myeloid leukemia: case report and a systematic review of the literature. ( 29357049 )
2018
34
Improved and adopted murine models to combat pulmonary aspergillosis. ( 29911293 )
2018
35
A case of allergic bronchopulmonary aspergillosis in a 43-year-old farmer following single high level exposure to organic dust with symptomatic remission and radiological resolution after early diagnosis and treatment. ( 29479448 )
2018
36
Diagnosis of Invasive Aspergillosis in Hematological Malignancy Patients: Performance of Cytokines, Asp LFD, and Aspergillus PCR in Same Day Blood and Bronchoalveolar Lavage Samples. ( 29972764 )
2018
37
The burden of Invasive Aspergillosis in patients with haematological malignancy: A meta-analysis and systematic review. ( 29727605 )
2018
38
Invasive Aspergillosis Mimicking Metastatic Lung Cancer. ( 29922593 )
2018
39
Utility of recombinant Aspergillus fumigatus antigens in the diagnosis of allergic bronchopulmonary aspergillosis: a systematic review and diagnostic test accuracy meta-analysis. ( 29927507 )
2018
40
Anti-IgE therapy for allergic bronchopulmonary aspergillosis in people with cystic fibrosis. ( 29551015 )
2018
41
Galactomannan, a Surrogate Marker for Outcome in Invasive Aspergillosis: Finally Coming of Age. ( 29670608 )
2018
42
Invasive Aspergillosis with Pulmonary and Central Nervous System involvement during ibrutinib therapy for relapsed Chronic Lymphocytic Leukaemia, a case report. ( 29427802 )
2018
43
Treatment of Sinonasal Aspergillosis by Debridement and Sinonasal Deposition Therapy with Clotrimazole Under Rhinoscopic Guidance. ( 29372867 )
2018
44
Epidemiology and Outcomes of Hospitalizations With Invasive Aspergillosis in the United States, 2009-2013. ( 29718296 )
2018
45
Characterisation of the cellular and proteomic response of Galleria mellonella larvae to the development of invasive aspergillosis. ( 29954319 )
2018
46
Is it time for systematic voriconazole pharmacogenomic investigation for central nervous system aspergillosis? ( 29967027 )
2018
47
Low sensitivity of Lateral Flow Device-<i>Aspergillus</i>in patients with probable and proven aspergillosis: results from a multicentre evaluation. ( 29444833 )
2018
48
Outbreak of invasive aspergillosis in heart transplant recipients: The role of screening computed tomography scans in asymptomatic patients and universal antifungal prophylaxis. ( 29125713 )
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CT findings of fungal pneumonia with emphasis on aspergillosis. ( 29956050 )
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50
Mutations in EEA1 are associated with allergic bronchopulmonary aspergillosis and affect phagocytosis of Aspergillus fumigatus by human macrophages. ( 29547649 )
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Sources

Variations for Aspergillosis

About this section

ClinVar genetic disease variations for Aspergillosis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CLEC7A NM_197947.2(CLEC7A): c.714T> G (p.Tyr238Ter) single nucleotide variant Benign rs16910526 GRCh37 Chromosome 12, 10271087: 10271087
2 CLEC7A NM_197947.2(CLEC7A): c.714T> G (p.Tyr238Ter) single nucleotide variant Benign rs16910526 GRCh38 Chromosome 12, 10118488: 10118488
Sources

Expression for Aspergillosis

About this section
Search GEO for disease gene expression data for Aspergillosis.
Sources

Pathways for Aspergillosis

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Pathways related to Aspergillosis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14.05 CD209 CLEC7A CSF2 ELANE IFNG IL10
2
PEDF Induced Signaling 64
Show member pathways
 13.65 CCL17 CSF2 IFNG IL10 IL4 IL5
3
Akt Signaling 64
Show member pathways
 13.46 CCL17 CSF2 IL10 IL4 IL5 TLR2
4
IL-2 Pathway 64
Show member pathways
 13.18 IFNG IL4 TLR2 TLR4 TLR9 TNF
5
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 13.03 IFNG IL10 MBL2 SFTPA2 SFTPD TLR2
6
Influenza A 37
Show member pathways
 12.87 CD209 IFNG IL4 TLR2 TLR4 TLR9
7
Allograft rejection 1 37
Show member pathways
 12.85 IFNG IL10 IL4 IL5 TNF
8
Th17 cell differentiation 37
Show member pathways
 12.65 IFNG IL10 IL4 IL5 TLR2 TLR4
9
NF-kappaB Signaling 4
12.64 IFNG IL10 IL4 TLR2 TLR9 TNF
10
T cell receptor signaling pathway 37
Show member pathways
 12.51 CSF2 IFNG IL10 IL4 IL5 TNF
11
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.49 CSF2 IFNG IL4 TNF
12
JAK-STAT signaling pathway (KEGG) 37
Show member pathways
 12.45 CSF2 IFNG IL10 IL4 IL5
13
Toxoplasmosis 37
Show member pathways
 12.34 IFNG IL10 IL4 TLR2 TLR4 TNF
14
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.3 IFNG IL10 IL4 IL5 TNF
15
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.28 TLR2 TLR4 TLR9 TNF
16
Colorectal Cancer Metastasis 64
12.27 IFNG TLR2 TLR4 TLR9 TNF
17
C-type lectin receptor signaling pathway 37
Show member pathways
 12.27 CCL17 CD209 CLEC7A IL10 TLR9 TNF
18
IL-17 Family Signaling Pathways 65
Show member pathways
 12.19 CCL17 CFTR CSF2 IFNG IL4 IL5
19
Th1 Differentiation Pathway 65
Show member pathways
 12.13 IFNG IL10 TLR2 TLR4 TLR9 TNF
20
Phagosome 37
12.13 CD209 CLEC7A MBL2 SFTPA2 SFTPD TLR2
21
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.11 CCL17 IFNG IL10 IL4 IL5
22
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 12.09 CSF2 IFNG IL4 TLR2 TLR4 TNF
23
MAPK Pathway 72
Show member pathways
 12.08 IL5 TLR2 TLR4 TLR9
24
Spinal Cord Injury 1
12.06 IFNG IL4 TLR4 TNF
25
Tuberculosis 37
12.01 CD209 CLEC7A IFNG IL10 TLR2 TLR4
26
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.98 CD209 CSF2 IFNG IL10 IL4 IL5
27
Hematopoietic cell lineage 37
11.96 CSF2 IL4 IL5 TNF
28
Rheumatoid arthritis 37
11.96 CSF2 IFNG TLR2 TLR4 TNF
29
Interleukin-4 and 13 signaling 66
11.95 IL10 IL4 TNF
30
Amoebiasis 37
11.94 CSF2 IFNG IL10 TLR2 TLR4 TNF
31
Phagocytosis of Microbes 64
11.9 CLEC7A TLR2 TLR4 TLR9
32
Innate Lymphoid Cell Differentiation Pathways 65
11.9 IFNG IL10 IL4 IL5 TNF
33
Glucocorticoid receptor regulatory network 1
11.88 CSF2 IFNG IL4 IL5
34
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.85 CFTR CSF2 TLR4
35
Pertussis 37
11.85 IL10 SFTPA2 TLR4 TNF
36
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.85 CSF2 IFNG IL4 IL5 TNF
37
Salmonella infection (KEGG) 37
11.82 CSF2 IFNG TLR4
38
Dendritic Cells Developmental Lineage Pathway 65
11.8 CD209 CSF2 IFNG IL10 TLR9 TNF
39
Bacterial infections in CF airways 22
Show member pathways
 11.78 CFTR IFNG IL4 SFTPD TLR2 TLR4
40
IL4-mediated signaling events 1
11.76 CCL17 IL10 IL4 IL5
41
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.76 CCL17 CSF2 IFNG IL10 IL4 TNF
42
Lung fibrosis 1
11.74 CSF2 IL4 IL5 SFTPA2 TNF
43
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.68 CSF2 IFNG TNF
44
Interleukin-10 signaling 66
11.64 CSF2 IL10 IL4 TNF
45
Legionellosis 37
11.62 TLR2 TLR4 TNF
46
MSP-RON Signaling 64
11.62 IFNG TLR2 TLR4 TNF
47
Th2 Differentiation Pathway 65
11.56 CCL17 IFNG IL10 IL4 IL5
48
Malaria 37
11.49 IFNG IL10 TLR2 TLR4 TLR9 TNF
49
African trypanosomiasis 37
11.47 IFNG IL10 TLR9 TNF
50
Development and heterogeneity of the ILC family 1
11.42 IFNG IL4 IL5 TNF
Sources

GO Terms for Aspergillosis

About this section

Cellular components related to Aspergillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.7 CD209 CFTR ELANE MBL2 TLR2 TLR4
2 extracellular space GO:0005615 9.7 CCL17 CSF2 ELANE IFNG IL10 IL4
3 extracellular region GO:0005576 9.44 CCL17 CD209 CSF2 ELANE IFNG IL10
4 collagen trimer GO:0005581 9.43 MBL2 SFTPA2 SFTPD

Biological processes related to Aspergillosis according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.99 ELANE IL10 TLR2 TLR4
2 cellular response to lipopolysaccharide GO:0071222 9.98 CSF2 IL10 TLR4 TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 TLR2 TLR4 TLR9 TNF
4 positive regulation of inflammatory response GO:0050729 9.92 TLR2 TLR4 TLR9 TNF
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.91 IL10 IL5 TNF
6 cellular response to interferon-gamma GO:0071346 9.9 CCL17 TLR2 TLR4
7 defense response to Gram-positive bacterium GO:0050830 9.9 MBL2 TLR2 TNF
8 positive regulation of JNK cascade GO:0046330 9.89 TLR4 TLR9 TNF
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.89 CSF2 IFNG IL4
10 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.88 TLR4 TLR9 TNF
11 positive regulation of interleukin-6 production GO:0032755 9.88 TLR2 TLR4 TLR9 TNF
12 positive regulation of tumor necrosis factor production GO:0032760 9.87 TLR2 TLR4 TLR9
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.87 TLR2 TLR4 TLR9 TNF
14 defense response to bacterium GO:0042742 9.87 ELANE IL10 MBL2 SFTPD TLR4 TLR9
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.85 IFNG TLR4 TNF
16 positive regulation of B cell proliferation GO:0030890 9.84 IL4 IL5 TLR4 TLR9
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.83 TLR2 TLR4 TNF
18 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.83 TLR2 TLR4 TLR9
19 positive regulation of phagocytosis GO:0050766 9.83 MBL2 SFTPA2 SFTPD TNF
20 positive regulation of interferon-beta production GO:0032728 9.81 TLR2 TLR4 TLR9
21 positive regulation of interleukin-10 production GO:0032733 9.8 TLR2 TLR4 TLR9
22 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.79 TLR2 TLR4 TLR9
23 regulation of cytokine secretion GO:0050707 9.79 TLR2 TLR4 TLR9
24 I-kappaB phosphorylation GO:0007252 9.78 TLR2 TLR4 TLR9
25 negative regulation of interleukin-6 production GO:0032715 9.78 IL10 TLR4 TLR9 TNF
26 positive regulation of podosome assembly GO:0071803 9.77 CSF2 IL5 TNF
27 response to molecule of bacterial origin GO:0002237 9.77 IL10 TLR2 TLR9
28 positive regulation of interleukin-8 production GO:0032757 9.76 TLR2 TLR4 TLR9 TNF
29 inflammatory response GO:0006954 9.76 CCL17 CLEC7A IL10 IL5 TLR2 TLR4
30 positive regulation of macrophage activation GO:0043032 9.73 IL10 TLR4
31 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 IFNG TNF
32 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.73 IL10 TNF
33 positive regulation of interleukin-12 production GO:0032735 9.73 IFNG TLR2 TLR4 TLR9
34 dendritic cell differentiation GO:0097028 9.72 CSF2 IL4
35 negative regulation of interleukin-17 production GO:0032700 9.72 IFNG TLR4
36 macrophage activation GO:0042116 9.72 CSF2 TLR4
37 surfactant homeostasis GO:0043129 9.72 SFTPA2 SFTPD
38 positive regulation of MHC class II biosynthetic process GO:0045348 9.72 IL10 IL4 TLR4
39 cellular response to lipoteichoic acid GO:0071223 9.71 TLR2 TLR4
40 endothelial cell apoptotic process GO:0072577 9.71 IL10 TNF
41 positive regulation of interferon-beta biosynthetic process GO:0045359 9.71 TLR4 TLR9
42 positive regulation of chemokine production GO:0032722 9.71 TLR2 TLR4 TLR9 TNF
43 negative regulation of interleukin-8 production GO:0032717 9.7 IL10 TLR9
44 negative regulation of cytokine secretion involved in immune response GO:0002740 9.7 IL10 TNF
45 positive regulation of interleukin-18 production GO:0032741 9.69 TLR2 TLR9
46 positive regulation of interleukin-23 production GO:0032747 9.69 CSF2 IFNG
47 tumor necrosis factor production GO:0032640 9.69 TLR2 TLR9
48 positive regulation of toll-like receptor signaling pathway GO:0034123 9.68 TLR2 TLR9
49 regulation of isotype switching GO:0045191 9.68 IL10 IL4
50 type 2 immune response GO:0042092 9.67 IL10 IL4

Molecular functions related to Aspergillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 9.65 CD209 CLEC7A MBL2 SFTPA2 SFTPD
2 growth factor activity GO:0008083 9.62 CSF2 IL10 IL4 IL5
3 monosaccharide binding GO:0048029 9.43 SFTPA2 SFTPD
4 lipopolysaccharide receptor activity GO:0001875 9.37 TLR2 TLR4
5 signaling pattern recognition receptor activity GO:0008329 9.33 CLEC7A TLR2 TLR9
6 lipopolysaccharide binding GO:0001530 9.26 SFTPA2 SFTPD TLR2 TLR4
7 cytokine activity GO:0005125 9.17 CCL17 CSF2 IFNG IL10 IL4 IL5
8 protein binding GO:0005515 10.28 CCL17 CD209 CFTR CLEC7A CSF2 ELANE
Sources

Sources for Aspergillosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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