MCID: ASP006
MIFTS: 67

Aspergillosis

Categories: Genetic diseases, Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Aspergillosis

MalaCards integrated aliases for Aspergillosis:

Name: Aspergillosis 57 12 75 53 59 55 43 3 44 15 17 72 33
Aspergillosis, Susceptibility to 57 29 13 6 40
Infection Due to Aspergillus 12

Characteristics:

Orphanet epidemiological data:

59
aspergillosis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:13564
OMIM 57 614079
ICD9CM 35 117.3
MeSH 44 D001228
NCIt 50 C2886
SNOMED-CT 68 65553006
ICD10 33 B44 B44.9
MESH via Orphanet 45 D001228
ICD10 via Orphanet 34 B44.0 B44.1 B44.2 more
UMLS via Orphanet 73 C0004030
Orphanet 59 ORPHA1163
UMLS 72 C0004030

Summaries for Aspergillosis

NIH Rare Diseases : 53 Aspergillosis is an infection, growth, or allergic response caused by the Aspergillus fungus. There are several different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue. Another kind of aspergillosis is invasive aspergillosis. This infection usually affects people with weakened immune systems due to cancer, AIDS, leukemia, organ transplantation, chemotherapy, or other conditions or events that reduce the number of normal white blood cells. In this condition, the fungus invades and damages tissues in the body. Invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain). Aspergilloma, a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess, is a third kind of aspergillosis. This type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells. The fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas.

MalaCards based summary : Aspergillosis, also known as aspergillosis, susceptibility to, is related to invasive aspergillosis and allergic bronchopulmonary aspergillosis, and has symptoms including fever and pruritus. An important gene associated with Aspergillosis is CLEC7A (C-Type Lectin Domain Containing 7A), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Guaifenesin and Amphotericin B have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and liver, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney, heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system.

OMIM : 57 Aspergillus species are ubiquitous in nature and cause a wide spectrum of diseases, including saprophytic colonization of existing cavities (aspergilloma), allergic asthma, hypersensitivity pneumonitis, allergic bronchopulmonary aspergillosis, and disseminated disease associated with high mortality rates in patients with hematologic malignancies and recipients of solid organs and stem cell transplantations. Immunocompetent and nonatopic individuals are relatively resistant to infection, and disease occurs in the setting of host damage. Association of persistent inflammation with intractable infection is common in nonneutropenic patients after hematopoietic stem cell transplantation, as well as in allergic fungal diseases. The pathophysiology underlying Aspergillus infection highlights the bipolar nature of the inflammatory process in infection, in which early inflammation prevents or limits infection, but an uncontrolled response may oppose disease eradication (summary by Cunha et al., 2010). For information on familial occurrence of allergic bronchopulmonary aspergillosis, see 103920. (614079)

MedlinePlus : 43 Aspergillosis is a disease caused by a fungus (or mold) called Aspergillus. The fungus is very common in both indoors and outdoors. Most people breathe in the spores of the fungus every day without being affected. But some people get the disease. It usually occurs in people with lung diseases or weakened immune systems. There are different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA). Symptoms of ABPA include wheezing and coughing. ABPA can affect healthy people but it is most common in people with asthma or cystic fibrosis. Another kind is invasive aspergillosis, which damages tissues in the body. It usually affects the lungs. Sometimes it can also cause infection in other organs and spread throughout the body. It affects people who have immune system problems, such as people who have had a transplant, are taking high doses of steroids, or getting chemotherapy for some cancers. Your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, CT scan of the lungs, and an examination of tissues for signs of the fungus. Treatment is with antifungal drugs. If you have ABPA, you may also take steroids. Centers for Disease Control and Prevention

CDC : 3 Aspergillosis is an infection caused by Aspergillus, a common mold (a type of fungus) that lives indoors and outdoors. Most people breathe in Aspergillus spores every day without getting sick. However, people with weakened immune systems or lung diseases are at a higher risk of developing health problems due to Aspergillus. The types of health problems caused by Aspergillus include allergic reactions, lung infections, and infections in other organs.

Wikipedia : 75 Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus... more...

Related Diseases for Aspergillosis

Diseases in the Aspergillosis family:

Invasive Aspergillosis

Diseases related to Aspergillosis via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 902, show less)
# Related Disease Score Top Affiliating Genes
1 invasive aspergillosis 33.8 TLR9 TLR4 TLR2 SFTPD MBL2 IFNG
2 allergic bronchopulmonary aspergillosis 33.8 SFTPD SFTPA2 MBL2 IL5 IL4 CFTR
3 candidiasis 31.8 MBL2 IL10 IFNG CLEC7A
4 bronchiectasis 31.5 TLR2 MBL2 ELANE CFTR
5 hypereosinophilic syndrome 31.3 IL5 IL4 CCL17
6 hematopoietic stem cell transplantation 31.2 TNF IL10 IFNG CLEC7A
7 cystic fibrosis 31.1 TLR4 SFTPD MBL2 ELANE CFTR
8 eosinophilic pneumonia 31.1 SFTPD IL5 CCL17
9 cryptococcosis 31.0 TLR9 MBL2 IL4 IFNG
10 immune deficiency disease 31.0 TLR9 IL4 IL10
11 ige responsiveness, atopic 31.0 IL5 IL4 IL10 IFNG
12 hyper ige syndrome 30.9 TLR2 IL4 IFNG
13 graft-versus-host disease 30.9 TNF IL10 IFNG
14 coccidioidomycosis 30.8 TLR4 MBL2 IL10 CLEC7A
15 allergic rhinitis 30.7 IL5 IL4 IL10 IFNG
16 pulmonary eosinophilia 30.7 SFTPD IL5 IL4 CCL17
17 conjunctivitis 30.6 IL5 IL4 IFNG
18 osteomyelitis 30.6 TNF IL10 IFNG
19 allergic asthma 30.6 IL5 IL4 IL10 IFNG CCL17
20 endocarditis 30.6 TNF TLR2 IL10
21 pneumocystosis 30.6 TNF SFTPD CLEC7A
22 chronic graft versus host disease 30.6 TNF IL10 IFNG
23 paranasal sinus disease 30.5 IL5 IL4 IL10 IFNG
24 bacterial pneumonia 30.5 TLR9 TLR4 SFTPD ELANE
25 allergic hypersensitivity disease 30.5 TLR9 IL5 IL4 IL10 IFNG CCL17
26 septic arthritis 30.5 TLR9 TLR4 TLR2
27 acute graft versus host disease 30.5 TNF IL4 IL10 IFNG
28 tetanus 30.4 IL5 IL4 IL10 IFNG
29 acute respiratory distress syndrome 30.4 TNF SFTPD ELANE
30 granulomatosis with polyangiitis 30.3 TLR9 TLR2 ELANE
31 idiopathic interstitial pneumonia 30.3 TLR9 SFTPD SFTPA2 IL4 IFNG ELANE
32 keratitis, hereditary 30.3 TLR9 TLR4 TLR2
33 food allergy 30.3 IL5 IL4 IL10 IFNG
34 bronchiolitis obliterans 30.3 TNF IL10 IFNG
35 folliculitis 30.3 IL5 IL4 IFNG
36 pulmonary disease, chronic obstructive 30.3 TNF TLR2 SFTPD ELANE CFTR
37 pulmonary sarcoidosis 30.3 TNF SFTPD IFNG
38 bronchitis 30.2 TNF IL5 ELANE CFTR
39 penicilliosis 30.2 TNF TLR4 TLR2
40 pyelonephritis 30.2 TNF TLR4 IL10
41 neuritis 30.2 TNF IL4 IFNG
42 fungal keratitis 30.1 TLR4 TLR2 CLEC7A CD209
43 peritonitis 30.1 TNF TLR2 IL10
44 dermatitis 30.1 TLR9 IL5 IL4 IFNG CCL17
45 stevens-johnson syndrome/toxic epidermal necrolysis 30.1 TLR9 IL5 IFNG CCL17
46 uveitis 30.1 TNF IL4 IL10 IFNG
47 toxic shock syndrome 30.0 TNF TLR4 TLR2 IL4 IL10 IFNG
48 cutaneous t cell lymphoma 30.0 IL4 IFNG CCL17
49 systemic scleroderma 29.9 TLR9 SFTPD IFNG
50 churg-strauss syndrome 29.9 TNF IL5 IL10 CCL17
51 legionellosis 29.9 TNF TLR4 TLR2
52 acquired immunodeficiency syndrome 29.9 TNF IL10 IFNG CCL3
53 respiratory failure 29.9 TNF SFTPD ELANE
54 leprosy 3 29.9 TNF TLR2 IL10 IFNG
55 ulcerative colitis 29.9 TNF TLR4 IL10 IFNG
56 adult respiratory distress syndrome 29.9 TNF IL10 ELANE
57 nontuberculous mycobacterial lung disease 29.9 TNF TLR2 CFTR
58 endomyocardial fibrosis 29.8 TNF IL4 IL10
59 acute pancreatitis 29.8 IL10 ELANE CFTR
60 lepromatous leprosy 29.8 TNF TLR2 IL10 IFNG
61 staphylococcal toxic shock syndrome 29.8 TNF IFNG
62 aseptic meningitis 29.7 TNF IL10 IFNG
63 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 29.7 IL4 IL10 IFNG CD209
64 sarcoidosis 1 29.7 TNF IFNG CCL3 CCL17
65 erythema multiforme 29.6 TNF IFNG CCL17
66 melioidosis 29.6 TNF TLR4 TLR2 IL10 IFNG
67 otitis media 29.6 TNF TLR4 TLR2 MBL2 IL4 IL10
68 nervous system disease 29.6 TNF TLR9 IL10 IFNG
69 interstitial lung disease 29.6 TNF SFTPD IL4 IL10 IFNG CCL17
70 chronic mucocutaneous candidiasis 29.6 TNF IL10 IFNG CLEC7A
71 perinatal necrotizing enterocolitis 29.6 TNF TLR9 TLR4
72 bacterial sepsis 29.6 TNF TLR4 IL10 ELANE
73 autoimmune disease 29.6 TNF TLR9 IL4 IL10 IFNG
74 mycobacterium abscessus 29.6 TNF TLR2 CLEC7A CFTR
75 typhoid fever 29.6 TNF TLR4 IFNG CFTR
76 aplastic anemia 29.5 TNF IL4 IFNG CCL3
77 leptospirosis 29.5 TNF TLR2 IL10 IFNG
78 plasmodium falciparum malaria 29.5 TNF TLR9 IL10 IFNG
79 filarial elephantiasis 29.5 TLR9 TLR2 IL5 IL4 IL10
80 gastroenteritis 29.4 TNF IL5 IL4 IL10
81 opportunistic mycosis 29.4 TNF TLR9 TLR2 IL4 IL10 IFNG
82 pulmonary edema 29.4 TNF IL10 CFTR
83 colitis 29.3 TNF TLR9 TLR4 IL4 IL10 IFNG
84 inflammatory bowel disease 29.3 TNF TLR4 TLR2 IL4 IL10 IFNG
85 severe acute respiratory syndrome 29.3 TNF IFNG CD209
86 hepatitis e 29.2 TNF TLR3 IFNG
87 tonsillitis 29.2 TNF TLR9 IL4 IFNG
88 echinococcosis 29.2 TNF TLR4 TLR2 IL5 IL10 IFNG
89 middle ear disease 29.2 TNF TLR9 TLR4 TLR2
90 bacterial meningitis 29.2 TNF TLR9 TLR2 IL10
91 viral hepatitis 29.1 TNF TLR9 TLR2
92 coccidiosis 29.0 TNF TLR9 IL4 IL10 IFNG
93 measles 29.0 TLR3 TLR2 IL4 IFNG CD209
94 paracoccidioidomycosis 29.0 TNF TLR4 TLR2 IL5 IL4 IL10
95 connective tissue disease 29.0 TNF TLR9 SFTPD IL10 IFNG
96 chlamydia 29.0 TNF TLR4 TLR2 IL4 IL10 IFNG
97 tuberculous meningitis 28.8 TNF TLR2 CCL3
98 pulmonary tuberculosis 28.8 TNF TLR9 TLR2 MBL2 IL4 IL10
99 toxoplasmosis 28.8 TNF TLR9 TLR4 TLR2 IL4 IL10
100 dermatitis, atopic 28.8 TNF TLR9 IL5 IL4 IL10 IFNG
101 dengue hemorrhagic fever 28.7 TNF TLR3 IL10 IFNG CD209
102 systemic lupus erythematosus 28.7 TNF TLR9 TLR4 TLR2 MBL2 IL4
103 multiple sclerosis 28.6 TNF IL4 IL10 IFNG CCL3
104 mycobacterium tuberculosis 1 28.5 TNF TLR9 TLR4 TLR2 MBL2 IL4
105 human immunodeficiency virus type 1 28.4 TNF TLR3 IL10 IFNG CD209 CCL3
106 meningitis 28.4 TNF TLR9 TLR2 MBL2 IL10 IFNG
107 leishmaniasis 28.3 TNF TLR9 TLR4 TLR2 IL5 IL4
108 rheumatoid arthritis 28.2 TNF TLR4 TLR2 IL4 IL10 IFNG
109 bronchiolitis 28.1 TNF TLR9 TLR4 IL5 IL4 IL10
110 common variable immunodeficiency 28.1 TNF TLR9 TLR2 MBL2 IL5 IL4
111 bacterial infectious disease 27.8 TNF TLR9 TLR4 TLR3 TLR2 MBL2
112 pneumonia 27.7 TNF TLR9 TLR4 TLR2 SFTPD MBL2
113 pulmonary fibrosis, idiopathic 27.6 TNF TLR9 SFTPD SFTPA2 IFNG ELANE
114 lung disease 27.6 TNF TLR9 TLR2 SFTPD SFTPA2 MBL2
115 proteasome-associated autoinflammatory syndrome 1 27.5 TNF TLR4 TLR2 IL5 IL4 IL10
116 asthma 27.3 TNF TLR9 IL5 IL4 IL10 IFNG
117 malaria 26.9 TNF TLR9 TLR4 TLR2 IL5 IL4
118 allergic bronchopulmonary aspergillosis, familial 12.5
119 pulmonary aspergilloma 11.6
120 neuroaspergillosis 11.5
121 plastic bronchitis 11.5
122 neutropenia 10.8
123 hyperlucent lung 10.7 IL4 IL10 IFNG
124 cephalosporin allergy 10.7 IL5 IL10 IFNG
125 eosinophilic fasciitis 10.7 IL5 IFNG
126 baylisascariasis 10.7 IL4 IL10 IFNG
127 prosthetic joint infection 10.7 TLR4 TLR2 MBL2
128 buruli ulcer 10.6 IL4 IL10 IFNG
129 multicentric castleman disease 10.6 IL5 IL10 IFNG
130 atopic keratoconjunctivitis 10.6 IL5 IL4 IFNG
131 milk allergy 10.6 IL5 IL4 IL10
132 neisseria meningitidis infection 10.6 TLR4 TLR2 MBL2
133 toxic oil syndrome 10.6 IL5 IL4 IFNG
134 peanut allergy 10.6 IL10 IFNG CCL17
135 urinary schistosomiasis 10.6 IL5 IL4 IFNG
136 gaucher disease, type ii 10.6 IL5 IL4 IL10
137 eosinophilic meningitis 10.6 IL5 IL4 IL10
138 mucormycosis 10.6
139 extrapulmonary tuberculosis 10.6 TLR2 IL10 IFNG
140 acute leukemia 10.6
141 chronic granulomatous disease 10.6
142 enterobiasis 10.6 TLR4 IL5 IL4
143 fibrosis of extraocular muscles, congenital, 1 10.5
144 lymphocytic leukemia 10.5
145 miliaria rubra 10.5 IL10 CFTR
146 vulvovaginal candidiasis 10.5 TLR2 MBL2 IL4 CLEC7A
147 leukemia, acute myeloid 10.5
148 nickel allergic contact dermatitis 10.5 IL5 IL4 IL10 IFNG
149 acute interstitial pneumonia 10.5 SFTPD SFTPA2
150 spastic paraplegia, intellectual disability, nystagmus, and obesity 10.5
151 granulocytopenia 10.5
152 myeloid leukemia 10.5
153 leukemia, acute lymphoblastic 10.5
154 leukemia 10.4
155 pneumothorax 10.4
156 suppurative otitis media 10.4 TLR9 TLR4 TLR2
157 apple allergy 10.4 IL5 IL4 IL10 CCL17
158 pulmonary fibrosis 10.4
159 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.4
160 rhinitis 10.4
161 punctate inner choroidopathy 10.4 TNF IL10
162 hand, foot and mouth disease 10.4 TLR3 IL10 IFNG
163 mycetoma 10.4
164 myelodysplastic syndrome 10.3
165 yellow fever 10.3 TLR9 IL5 IL4
166 myositis fibrosa 10.3 TLR9 TLR4 TLR2 IFNG
167 influenza 10.3
168 tropical endomyocardial fibrosis 10.3 TNF IL4 IL10
169 exophthalmos 10.3
170 clonorchiasis 10.3 TNF IL10 IFNG
171 liver cirrhosis 10.3
172 genital herpes 10.3 TLR9 TLR2 IL4 IL10
173 vasculitis 10.3
174 intermediate uveitis 10.3 TNF IL10 IFNG
175 haemophilus influenzae 10.3 TNF TLR2 CLEC7A
176 tungiasis 10.3 TNF IL4 IL10
177 bronchopneumonia 10.3
178 spotted fever 10.3 TNF IL10 IFNG
179 nasal cavity disease 10.3 TLR9 IL5 IL4 IL10
180 sezary's disease 10.3 TLR9 IL5 IL4 IFNG
181 respiratory allergy 10.2 TLR9 IL5 IL4 IL10
182 plasmodium vivax malaria 10.2 TNF IL10 IFNG
183 trench fever 10.2 TNF TLR4 TLR2
184 cow milk allergy 10.2 TNF IL5 IL10
185 autoimmune gastritis 10.2 TNF IL4 IL10
186 endophthalmitis 10.2
187 eye lymphoma 10.2 TLR9 IL10
188 kearns-sayre syndrome 10.2
189 pleural empyema 10.2
190 cytokine deficiency 10.2
191 rasmussen encephalitis 10.2 TNF IL4 IFNG
192 mixed connective tissue disease 10.2 TNF IL10 IFNG
193 lupus erythematosus 10.2
194 rheumatic fever 10.2 TNF MBL2 IL10
195 spondylarthropathy 10.2 TNF TLR4 TLR2
196 reactive arthritis 10.2 TNF IL10 IFNG
197 hepatitis a 10.2 TNF IL10 IFNG
198 acute kidney failure 10.2
199 autoimmune myocarditis 10.2 TNF IFNG
200 multifocal choroiditis 10.2 TNF IL10
201 idiopathic neutropenia 10.2 TNF TLR4 IL10
202 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 TNF IL5
203 purpura 10.2
204 oral cavity cancer 10.2 TLR9 TLR2 IL4
205 allergic conjunctivitis 10.2 TLR3 IL5 IL4 IFNG
206 lung cancer 10.2
207 ptosis 10.2
208 lymphopenia 10.2
209 rare surgical neurologic disease 10.2
210 conjunctival disease 10.2 TNF IL5 IL4
211 ileitis 10.2 TNF TLR4 TLR2
212 inflammatory spondylopathy 10.2
213 thrombocytopenia 10.2
214 spondylitis 10.2
215 headache 10.1
216 eales disease 10.1 TNF IL4 IL10 IFNG
217 poliomyelitis 10.1 TNF IL4 IL10 IFNG
218 periodontosis 10.1 TNF TLR4 ELANE
219 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
220 lung abscess 10.1
221 extrinsic allergic alveolitis 10.1
222 crohn's disease 10.1
223 47,xyy 10.1
224 aneurysm 10.1
225 cytomegalovirus infection 10.1
226 spondyloarthropathy 10.1 TNF IL4 IL10 IFNG
227 autoimmune uveitis 10.1 TNF IL4 IL10 IFNG
228 testicular disease 10.1 TNF TLR2 IL10 IFNG
229 rubella 10.1 TNF IL4 IL10
230 rheumatic heart disease 10.1 TNF MBL2 IL4 IL10
231 lymphoma 10.1
232 histoplasmosis 10.1
233 maxillary sinusitis 10.1
234 nocardiosis 10.1
235 relapsing-remitting multiple sclerosis 10.1 TNF IL4 IL10 IFNG
236 scleritis 10.1 TNF IL5 IL4 IFNG
237 adult dermatomyositis 10.1 TNF TLR9 MBL2
238 scrub typhus 10.1 TNF TLR4 TLR2 IL10
239 myasthenia gravis 10.1 TNF IL4 IL10 IFNG
240 spondyloarthropathy 1 10.1
241 leukemia, chronic lymphocytic 10.1
242 ocular motor apraxia 10.1
243 pneumoconiosis 10.1
244 anthracosis 10.1
245 meningoencephalitis 10.1
246 pancytopenia 10.1
247 diarrhea 10.1
248 hypokalemia 10.1
249 kidney disease 10.1
250 paraplegia 10.1
251 neuropathy 10.1
252 eosinophilic granulomatosis with polyangiitis 10.1
253 leukemia, b-cell, chronic 10.1
254 pulmonary sequestration 10.1
255 acute liver failure 10.1
256 bacterial vaginosis 10.1 TNF TLR4 TLR2 MBL2
257 central nervous system vasculitis 10.1 TNF TLR9 IFNG
258 pustulosis palmaris et plantaris 10.1 TNF IL5 ELANE
259 aggressive periodontitis 10.1 TNF TLR4 IL4 IL10
260 aphthous stomatitis 10.1 TNF TLR2 IL4 IL10
261 tick-borne encephalitis 10.1 TLR3 IL10 CD209
262 alcohol dependence 10.1
263 thrombocytopenic purpura, autoimmune 10.1
264 leukemia, chronic myeloid 10.1
265 fusariosis 10.1
266 optic nerve disease 10.1
267 hematologic cancer 10.1
268 autoimmune disease of eyes, ear, nose and throat 10.0 TNF TLR9 IL10
269 palladium allergic contact dermatitis 10.0 IL10 CCL3 CCL17
270 lung cancer susceptibility 3 10.0
271 deficiency anemia 10.0
272 actinomycosis 10.0
273 48,xyyy 10.0
274 homologous wasting disease 10.0
275 hypersensitivity reaction type iv disease 10.0 TNF TLR9 IFNG
276 lacrimal apparatus disease 10.0 TNF TLR9 IL10
277 alveolar echinococcosis 10.0 TNF TLR4 TLR2 CCL17
278 chorioamnionitis 10.0 TNF TLR4 ELANE
279 pneumothorax, primary spontaneous 10.0
280 temporal arteritis 10.0
281 myeloma, multiple 10.0
282 yemenite deaf-blind hypopigmentation syndrome 10.0
283 sphenoid sinusitis 10.0
284 pericarditis 10.0
285 myocarditis 10.0
286 amyloidosis 10.0
287 encephalitis 10.0
288 pituitary tumors 10.0
289 lymph node disease 10.0 TNF TLR9 IL10
290 uveal disease 10.0 TNF TLR9 IL10
291 kawasaki disease 10.0 TNF MBL2 IL10 ELANE
292 diabetes mellitus, ketosis-prone 10.0
293 exanthem 10.0
294 aphasia 10.0
295 thrombosis 10.0
296 optic neuritis 10.0
297 farmer's lung 10.0
298 glomerulonephritis 10.0
299 cellulitis 10.0
300 end stage renal failure 10.0
301 mediastinitis 10.0
302 orbital disease 10.0
303 pulmonary embolism 10.0
304 chronic eosinophilic pneumonia 10.0
305 scedosporiosis 10.0
306 brucellosis 9.9 TNF TLR4 IL4 IL10 IFNG
307 irritable bowel syndrome 9.9 TNF TLR9 IL10
308 gingivitis 9.9 TNF TLR2 IL4 ELANE
309 small cell cancer of the lung 9.9
310 enterocolitis 9.9
311 lymphoma, hodgkin, classic 9.9
312 pulmonary hypertension 9.9
313 atrioventricular block 9.9
314 cardiac tamponade 9.9
315 esophageal candidiasis 9.9
316 squamous cell carcinoma 9.9
317 middle lobe syndrome 9.9
318 adenocarcinoma 9.9
319 glioblastoma multiforme 9.9
320 hemolytic anemia 9.9
321 b-cell lymphoma 9.9
322 thyroiditis 9.9
323 pulmonary emphysema 9.9
324 glioblastoma 9.9
325 mycoplasma pneumoniae pneumonia 9.9 TNF TLR2 IL4 IL10 IFNG
326 lichen disease 9.9 TNF TLR9 IL4 IFNG
327 pertussis 9.9 TNF TLR4 IL10
328 omenn syndrome 9.9 TNF IL5 IL4 IL10 IFNG
329 keratoconjunctivitis sicca 9.9 TNF TLR9 IL4 IL10
330 rheumatic disease 9.9 TNF TLR9 IL10 IFNG
331 lichen planus 9.9 TNF TLR9 IL4 IFNG
332 autoimmune disease of musculoskeletal system 9.9 TNF TLR9 IL4 IL10
333 renal cell carcinoma, nonpapillary 9.9
334 lymphoma, non-hodgkin, familial 9.9
335 meningioma, radiation-induced 9.9
336 meningioma, familial 9.9
337 acute promyelocytic leukemia 9.9
338 cyanosis, transient neonatal 9.9
339 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 9.9
340 cardiac arrest 9.9
341 lymphoproliferative syndrome 9.9
342 neuroretinitis 9.9
343 silicosis 9.9
344 spinal meningioma 9.9
345 pulmonary alveolar proteinosis 9.9
346 autoimmune hepatitis 9.9
347 agammaglobulinemia 9.9
348 myelitis 9.9
349 central nervous system disease 9.9
350 retinitis 9.9
351 hyperglycemia 9.9
352 pyoderma 9.9
353 secretory meningioma 9.9
354 lymphoplasmacyte-rich meningioma 9.9
355 adenoma 9.9
356 cataract 9.9
357 intracranial hypertension 9.9
358 fasciitis 9.9
359 polyarteritis nodosa 9.9
360 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 9.9
361 allergic angiitis 9.9
362 glioma 9.9
363 microscopic polyangiitis 9.9
364 dysphagia 9.9
365 glial tumor 9.9
366 argyria 9.9
367 intestinal disease 9.9 TNF TLR9 TLR4 IL10
368 necatoriasis 9.8 IL5 IL10 CCL3 CCL17
369 leukocyte disease 9.8 TNF TLR9 IL5 IL4
370 pemphigus vulgaris, familial 9.8
371 anemia, autoimmune hemolytic 9.8
372 neuroblastoma 1 9.8
373 asthma-related traits 2 9.8
374 leukemia, acute lymphoblastic 3 9.8
375 dengue shock syndrome 9.8
376 diffuse large b-cell lymphoma 9.8
377 intracranial abscess 9.8
378 dermatomyositis 9.8
379 pleurisy 9.8
380 chronic meningitis 9.8
381 mastitis 9.8
382 thrombotic thrombocytopenic purpura 9.8
383 chronic maxillary sinusitis 9.8
384 hydrocephalus 9.8
385 orbital cellulitis 9.8
386 disseminated intravascular coagulation 9.8
387 epidural abscess 9.8
388 choroiditis 9.8
389 esophagitis 9.8
390 primary biliary cirrhosis 9.8
391 alcoholic hepatitis 9.8
392 blastomycosis 9.8
393 acute cystitis 9.8
394 phaeohyphomycosis 9.8
395 oral candidiasis 9.8
396 geotrichosis 9.8
397 hairy cell leukemia 9.8
398 laryngitis 9.8
399 cavernous sinus thrombosis 9.8
400 aortic aneurysm 9.8
401 liver disease 9.8
402 aortitis 9.8
403 peripheral nervous system disease 9.8
404 combined t cell and b cell immunodeficiency 9.8
405 cerebrovascular disease 9.8
406 hodgkin's lymphoma, lymphocytic-histiocytic predominance 9.8
407 pyoderma gangrenosum 9.8
408 megakaryocytic leukemia 9.8
409 hard palate cancer 9.8
410 pemphigus 9.8
411 diabetes mellitus 9.8
412 status asthmaticus 9.8
413 diabetes insipidus 9.8
414 dacryoadenitis 9.8
415 dacryocystitis 9.8
416 congenital hydrocephalus 9.8
417 hansen's disease 9.8
418 primary biliary cholangitis 9.8
419 encephalopathy 9.8
420 hypoxia 9.8
421 idiopathic bronchiectasis 9.8
422 primary systemic mycosis 9.8 TNF TLR2 IL4 IL10 IFNG CLEC7A
423 autoimmune disease of central nervous system 9.8 TNF TLR9 IL4 IL10 IFNG
424 bone inflammation disease 9.8 TNF TLR9 IL4 IL10 IFNG
425 gastrointestinal system disease 9.7 TNF TLR9 TLR4 IL10 IFNG
426 q fever 9.7 TNF TLR4 TLR2 IL4 IL10 IFNG
427 burkitt lymphoma 9.7
428 breast cancer 9.7
429 felty syndrome 9.7
430 leukemia, acute monocytic 9.7
431 strabismus 9.7
432 torticollis 9.7
433 triiodothyronine receptor auxiliary protein 9.7
434 osteogenic sarcoma 9.7
435 graves disease 1 9.7
436 wilms tumor 5 9.7
437 kala-azar 1 9.7
438 myocardial infarction 9.7
439 hepatitis c virus 9.7
440 mycobacterium tuberculosis 2 9.7
441 hydrops, lactic acidosis, and sideroblastic anemia 9.7
442 aspiration pneumonia 9.7
443 cutaneous lupus erythematosus 9.7
444 adult t-cell leukemia 9.7
445 peripheral t-cell lymphoma 9.7
446 follicular lymphoma 9.7
447 infective endocarditis 9.7
448 clostridium difficile colitis 9.7
449 angioimmunoblastic t-cell lymphoma 9.7
450 common cold 9.7
451 viral pneumonia 9.7
452 interstitial nephritis 9.7
453 strongyloidiasis 9.7
454 hemiplegia 9.7
455 prostatic hypertrophy 9.7
456 enophthalmos 9.7
457 ornithosis 9.7
458 hepatorenal syndrome 9.7
459 nephrotic syndrome 9.7
460 hemosiderosis 9.7
461 goiter 9.7
462 dengue disease 9.7
463 acoustic neuroma 9.7
464 tolosa-hunt syndrome 9.7
465 dilated cardiomyopathy 9.7
466 polyneuropathy 9.7
467 facial paralysis 9.7
468 alcoholic liver cirrhosis 9.7
469 papilledema 9.7
470 prostatitis 9.7
471 pleural disease 9.7
472 neuroma 9.7
473 constipation 9.7
474 b cell deficiency 9.7
475 papilloma 9.7
476 transitional cell carcinoma 9.7
477 antiphospholipid syndrome 9.7
478 rhabdomyosarcoma 9.7
479 carotid artery thrombosis 9.7
480 cranial nerve palsy 9.7
481 pituitary adenoma 9.7
482 gastritis 9.7
483 carcinosarcoma 9.7
484 pustulosis of palm and sole 9.7
485 skull base meningioma 9.7
486 large cell carcinoma 9.7
487 brain edema 9.7
488 proliferative glomerulonephritis 9.7
489 pancreatitis 9.7
490 urinary tract obstruction 9.7
491 severe combined immunodeficiency 9.7
492 lung lymphoma 9.7
493 t-cell leukemia 9.7
494 laryngeal disease 9.7
495 hyperthyroidism 9.7
496 monocytic leukemia 9.7
497 collagen disease 9.7
498 herpes simplex 9.7
499 myeloid sarcoma 9.7
500 psoriasis 9.7
501 dermatophytosis 9.7
502 mechanical strabismus 9.7
503 hypopituitarism 9.7
504 cholangitis 9.7
505 necrotizing fasciitis 9.7
506 miliary tuberculosis 9.7
507 hemophilia 9.7
508 hypertrophic cardiomyopathy 9.7
509 sickle cell disease 9.7
510 acute monoblastic leukemia 9.7
511 autoimmune gastrointestinal dysmotility 9.7
512 cytomegalic inclusion disease 9.7
513 leukemia, t-cell, chronic 9.7
514 lymphosarcoma 9.7
515 mycobacterium malmoense 9.7
516 pleuroparenchymal fibroelastosis 9.7
517 polymyositis 9.7
518 recurrent respiratory papillomatosis 9.7
519 stenotrophomonas maltophilia infection 9.7
520 tracheoesophageal fistula 9.7
521 back pain 9.7
522 meningitis and encephalitis 9.7
523 seizure disorder 9.7
524 posttransplant acute limbic encephalitis 9.7
525 subacute cutaneous lupus erythematosus 9.7
526 virus-associated trichodysplasia spinulosa 9.7
527 myospherulosis 9.7
528 secondary pulmonary alveolar proteinosis 9.7
529 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 9.7
530 thrombotic microangiopathy 9.7
531 extrinsic cardiomyopathy 9.7 TNF TLR9 TLR4 IL4 IL10
532 lymphadenitis 9.7 TNF TLR4 IL10 IFNG CD209
533 nose disease 9.7 TNF TLR9 IL5 IL4 IL10
534 parasitic helminthiasis infectious disease 9.7 TNF TLR9 IL5 IL4 IL10
535 allergic contact dermatitis 9.7 TNF IL5 IL4 IL10 IFNG CCL17
536 contact dermatitis 9.7 TNF IL5 IL4 IL10 IFNG CCL17
537 japanese encephalitis 9.7 TNF TLR3 CD209
538 variola major 9.7 TLR4 TLR3 IFNG CCL3
539 mucocutaneous leishmaniasis 9.6 TNF TLR9 TLR3 IL10
540 marburg hemorrhagic fever 9.6 TNF CD209
541 aortic aneurysm, familial abdominal, 1 9.6
542 neurofibromatosis, type ii 9.6
543 pfeiffer syndrome 9.6
544 atrial standstill 1 9.6
545 gastroesophageal reflux 9.6
546 bladder cancer 9.6
547 colorectal cancer 9.6
548 hepatocellular carcinoma 9.6
549 leukocyte adhesion deficiency, type i 9.6
550 creutzfeldt-jakob disease 9.6
551 epidermoid cysts 9.6
552 hyper-ige recurrent infection syndrome 1, autosomal dominant 9.6
553 immunoglobulin e concentration, serum 9.6
554 kaposi sarcoma 9.6
555 lipomatosis, multiple 9.6
556 marfan syndrome 9.6
557 medulloblastoma 9.6
558 myositis 9.6
559 porphyria cutanea tarda 9.6
560 pulmonary hypertension, primary, 1 9.6
561 scleroderma, familial progressive 9.6
562 spinal arachnoiditis 9.6
563 tetralogy of fallot 9.6
564 thrombophilia due to thrombin defect 9.6
565 digeorge syndrome 9.6
566 trigeminal neuralgia 9.6
567 wolff-parkinson-white syndrome 9.6
568 chondrosarcoma 9.6
569 schopf-schulz-passarge syndrome 9.6
570 aicardi-goutieres syndrome 1 9.6
571 endocardial fibroelastosis 9.6
572 fanconi anemia, complementation group a 9.6
573 gaucher disease, type i 9.6
574 hemolytic uremic syndrome, atypical 1 9.6
575 hydrocephalus due to congenital stenosis of aqueduct of sylvius 9.6
576 ciliary dyskinesia, primary, 1 9.6
577 nonarteritic anterior ischemic optic neuropathy 9.6
578 pancreatic cancer 9.6
579 pulmonary alveolar microlithiasis 9.6
580 reticulum cell sarcoma 9.6
581 agammaglobulinemia, x-linked 9.6
582 mcleod syndrome 9.6
583 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 9.6
584 pearson marrow-pancreas syndrome 9.6
585 prostatic hyperplasia, benign 9.6
586 budd-chiari syndrome 9.6
587 stroke, ischemic 9.6
588 langerhans cell histiocytosis 9.6
589 systemic lupus erythematosus 2 9.6
590 late-onset retinal degeneration 9.6
591 pars planitis 9.6
592 lymphangioleiomyomatosis 9.6
593 anorexia nervosa 9.6
594 nasopharyngeal carcinoma 9.6
595 asthma-related traits 1 9.6
596 coronary heart disease 1 9.6
597 severe cutaneous adverse reaction 9.6
598 esophagitis, eosinophilic, 1 9.6
599 pulmonary alveolar proteinosis, acquired 9.6
600 intraocular pressure quantitative trait locus 9.6
601 candidiasis, familial, 4 9.6
602 gastric cancer 9.6
603 nail disorder, nonsyndromic congenital, 10 9.6
604 immunodeficiency 21 9.6
605 barrett esophagus 9.6
606 dengue virus 9.6
607 mannose-binding lectin deficiency 9.6
608 immunodeficiency 12 9.6
609 hyperprolactinemia 9.6
610 cholangiocarcinoma 9.6
611 angina pectoris 9.6
612 adrenal cortical carcinoma 9.6
613 adiaspiromycosis 9.6
614 hemophagocytic lymphohistiocytosis 9.6
615 kartagener syndrome 9.6
616 otomycosis 9.6
617 cryptogenic organizing pneumonia 9.6
618 selective igm deficiency disease 9.6
619 multinodular goiter 9.6
620 severe congenital neutropenia 9.6
621 small cell carcinoma 9.6
622 autosomal recessive disease 9.6
623 mantle cell lymphoma 9.6
624 t-cell large granular lymphocyte leukemia 9.6
625 hemorrhagic cystitis 9.6
626 large cell neuroendocrine carcinoma 9.6
627 inflammatory myofibroblastic tumor 9.6
628 apraxia 9.6
629 balo concentric sclerosis 9.6
630 paroxysmal nocturnal hemoglobinuria 9.6
631 tracheomalacia 9.6
632 pollen allergy 9.6
633 drug allergy 9.6
634 salmonellosis 9.6
635 bone disease 9.6
636 cryptococcal meningitis 9.6
637 cytomegalovirus retinitis 9.6
638 hepatic veno-occlusive disease 9.6
639 mucositis 9.6
640 chronic myelomonocytic leukemia 9.6
641 polycystic kidney disease 9.6
642 bronchiectasis 2 9.6
643 castleman disease 9.6
644 cerebral artery occlusion 9.6
645 pleomorphic lipoma 9.6
646 asbestosis 9.6
647 berylliosis 9.6
648 byssinosis 9.6
649 chronic leukemia 9.6
650 hypopyon 9.6
651 portal hypertension 9.6
652 frontal sinusitis 9.6
653 gastric ulcer 9.6
654 abducens nerve disease 9.6
655 cholesteatoma of middle ear 9.6
656 discitis 9.6
657 hydronephrosis 9.6
658 sarcoma 9.6
659 t cell deficiency 9.6
660 megacolon 9.6
661 cerebral arteritis 9.6
662 xanthogranulomatous pyelonephritis 9.6
663 hemopericardium 9.6
664 horner's syndrome 9.6
665 listeriosis 9.6
666 gestational diabetes 9.6
667 pericardial effusion 9.6
668 arachnoiditis 9.6
669 cough variant asthma 9.6
670 graves' disease 9.6
671 tinea pedis 9.6
672 hepatic coma 9.6
673 hemolytic-uremic syndrome 9.6
674 posterior uveitis 9.6
675 quadriplegia 9.6
676 leukostasis 9.6
677 carotid stenosis 9.6
678 relapsing fever 9.6
679 periventricular leukomalacia 9.6
680 hellp syndrome 9.6
681 crescentic glomerulonephritis 9.6
682 porphyria 9.6
683 klebsiella pneumonia 9.6
684 exocrine pancreatic insufficiency 9.6
685 neurosarcoidosis 9.6
686 cholestasis 9.6
687 eclampsia 9.6
688 obstructive jaundice 9.6
689 biliary atresia 9.6
690 panophthalmitis 9.6
691 acute closed-angle glaucoma 9.6
692 multiple cranial nerve palsy 9.6
693 bird fancier's lung 9.6
694 squamous cell papilloma 9.6
695 pleuropneumonia 9.6
696 suppurative thyroiditis 9.6
697 acute thyroiditis 9.6
698 pyuria 9.6
699 capillary leak syndrome 9.6
700 hypothyroidism 9.6
701 panniculitis 9.6
702 urticaria 9.6
703 chromoblastomycosis 9.6
704 ectropion 9.6
705 alcohol use disorder 9.6
706 thrombocytopenia due to platelet alloimmunization 9.6
707 pineoblastoma 9.6
708 cystitis 9.6
709 heart septal defect 9.6
710 cryptosporidiosis 9.6
711 cheilitis 9.6
712 toxic megacolon 9.6
713 vascular disease 9.6
714 neuroendocrine carcinoma 9.6
715 status epilepticus 9.6
716 gaucher's disease 9.6
717 trichomoniasis 9.6
718 cholecystitis 9.6
719 hepatitis b 9.6
720 hyperostosis 9.6
721 intestinal perforation 9.6
722 thrombocytosis 9.6
723 hepatitis 9.6
724 colon adenocarcinoma 9.6
725 neonatal jaundice 9.6
726 splenic abscess 9.6
727 larynx cancer 9.6
728 nonspecific interstitial pneumonia 9.6
729 laryngeal squamous cell carcinoma 9.6
730 prostatic adenoma 9.6
731 primary hyperoxaluria 9.6
732 anuria 9.6
733 testicular cancer 9.6
734 astrocytoma 9.6
735 malignant glioma 9.6
736 papillary adenocarcinoma 9.6
737 oligodendroglioma 9.6
738 central nervous system lymphoma 9.6
739 aspiration pneumonitis 9.6
740 lipid pneumonia 9.6
741 embryonal rhabdomyosarcoma 9.6
742 ischemia 9.6
743 hyper ige recurrent infection syndrome 1 9.6
744 histiocytosis 9.6
745 carotid artery disease 9.6
746 cerebritis 9.6
747 skin carcinoma 9.6
748 plague 9.6
749 lactic acidosis 9.6
750 olfactory neuroblastoma 9.6
751 hermansky-pudlak syndrome 9.6
752 craniopharyngioma 9.6
753 lung squamous cell carcinoma 9.6
754 schneiderian carcinoma 9.6
755 multidrug-resistant tuberculosis 9.6
756 eosinophilic gastroenteritis 9.6
757 fungal gastritis 9.6
758 tick infestation 9.6
759 nail disease 9.6
760 syphilis 9.6
761 myopathy 9.6
762 spindle cell sarcoma 9.6
763 intracranial embolism 9.6
764 uremia 9.6
765 extragonadal germ cell cancer 9.6
766 atrophic rhinitis 9.6
767 rapidly progressive glomerulonephritis 9.6
768 benign ependymoma 9.6
769 intrahepatic cholangiocarcinoma 9.6
770 elephantiasis 9.6
771 ureteral obstruction 9.6
772 infertility 9.6
773 pulmonary coin lesion 9.6
774 bronchus adenoma 9.6
775 lung oat cell carcinoma 9.6
776 toxic pneumonitis 9.6
777 acute t cell leukemia 9.6
778 hemoglobinuria 9.6
779 congestive heart failure 9.6
780 thyroid hyalinizing trabecular adenoma 9.6
781 transient hypogammaglobulinemia of infancy 9.6
782 transient hypogammaglobulinemia 9.6
783 pulmonary large cell neuroendocrine carcinoma 9.6
784 hepatoblastoma 9.6
785 refractory hairy cell leukemia 9.6
786 subacute thyroiditis 9.6
787 meningothelial meningioma 9.6
788 axonal neuropathy 9.6
789 monoclonal gammopathy of uncertain significance 9.6
790 active peptic ulcer disease 9.6
791 chronic kidney disease 9.6
792 carotid artery occlusion 9.6
793 cocaine abuse 9.6
794 chronic rhinitis 9.6
795 appendicitis 9.6
796 intestinal obstruction 9.6
797 ileus 9.6
798 intestinal volvulus 9.6
799 arthritis 9.6
800 rheumatoid arthritis interstitial lung disease 9.6
801 bullous pemphigoid 9.6
802 molluscum contagiosum 9.6
803 chorioretinitis 9.6
804 mitochondrial encephalomyopathy 9.6
805 pityriasis versicolor 9.6
806 macroglobulinemia 9.6
807 amebiasis 9.6
808 cleft lip 9.6
809 scotoma 9.6
810 fatty liver disease 9.6
811 ethmoid sinusitis 9.6
812 primary ciliary dyskinesia 9.6
813 dextrocardia 9.6
814 plantar fasciitis 9.6
815 trichinosis 9.6
816 toxocariasis 9.6
817 alopecia 9.6
818 chronic dacryocystitis 9.6
819 hypervitaminosis d 9.6
820 hypoglycemia 9.6
821 mitochondrial disorders 9.6
822 acute myeloblastic leukemia with maturation 9.6
823 acute myeloblastic leukemia without maturation 9.6
824 acute necrotizing encephalopathy 9.6
825 acute non lymphoblastic leukemia 9.6
826 anca-associated vasculitis 9.6
827 aspergillus niger infection 9.6
828 candida glabrata 9.6
829 catastrophic antiphospholipid syndrome 9.6
830 chromosomal triplication 9.6
831 cystic adenomatoid malformation of lung 9.6
832 eosinophilic enteropathy 9.6
833 ependymoma 9.6
834 fibrosing mediastinitis 9.6
835 fournier gangrene 9.6
836 germ cells tumors 9.6
837 idiopathic hypertrophic pachymeningitis 9.6
838 laryngocele 9.6
839 mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes 9.6
840 mycobacterium avium complex infections 9.6
841 mycobacterium fortuitum 9.6
842 mycobacterium kansasii 9.6
843 mycobacterium xenopi 9.6
844 plasma cell leukemia 9.6
845 post-transplant lymphoproliferative disease 9.6
846 primary central nervous system lymphoma 9.6
847 sinonasal undifferentiated carcinoma 9.6
848 splenomegaly 9.6
849 swyer-james syndrome 9.6
850 syndrome of inappropriate antidiuretic hormone 9.6
851 systemic capillary leak syndrome 9.6
852 cerebral aneurysms 9.6
853 head injury 9.6
854 paresthesia 9.6
855 spasticity 9.6
856 spinal cord injury 9.6
857 tremor 9.6
858 rare mycosis 9.6
859 asbestos intoxication 9.6
860 rapidly involuting congenital hemangioma 9.6
861 rare hereditary hemochromatosis 9.6
862 voriconazole toxicity 9.6
863 igg4-related pachymeningitis 9.6
864 eosinophilic colitis 9.6
865 erythema multiforme major 9.6
866 benign idiopathic neonatal seizures 9.6
867 obsolete: ehlers-danlos syndrome, fibronectinemic type 9.6
868 pik3ca-related overgrowth syndrome 9.6
869 staphylococcal scarlet fever 9.6
870 classic pyoderma gangrenosum 9.6
871 diffuse alveolar hemorrhage 9.6
872 discoid lupus erythematosus 9.6
873 rare tumor 9.6
874 rare disease in surgical orthopedic 9.6
875 cardiogenic shock 9.6
876 refractory anemia 9.6
877 intravascular large b-cell lymphoma 9.6
878 polyendocrinopathy 9.6
879 thyroid carcinoma 9.6
880 eosinophilic granuloma 9.6
881 parasitic protozoa infectious disease 9.6 TNF TLR9 TLR2 IL4 IL10 IFNG
882 upper respiratory tract disease 9.5 TNF TLR9 IL5 IL4 IL10 IFNG
883 demyelinating disease 9.5 TNF IL10 IFNG CCL3
884 keratoconjunctivitis 9.5 TNF TLR9 IL5 IL4 IFNG CCL17
885 large intestine cancer 9.4 TNF TLR9 IL10 IFNG
886 bronchial disease 9.4 TNF TLR9 IL5 IL4 IL10 ELANE
887 orofacial granulomatosis 9.4 TNF IL4 IL10 IFNG CCL3
888 primary bacterial infectious disease 9.4 TNF TLR9 TLR4 TLR2 IL4 IL10
889 visceral leishmaniasis 9.4 TNF TLR9 TLR4 TLR2 IL4 IL10
890 periodontitis 9.4 TNF TLR9 TLR4 TLR2 IL4 IL10
891 filariasis 9.3 TNF TLR9 TLR4 TLR2 IL5 IL10
892 mouth disease 9.3 TNF TLR9 TLR4 TLR3 IL10 IFNG
893 skin disease 9.3 TNF TLR9 IL5 IL4 IL10 IFNG
894 human immunodeficiency virus infectious disease 9.2 TNF TLR9 IL10 IFNG CCL3
895 chagas disease 9.2 TNF TLR4 TLR2 IL10 IFNG CCL3
896 schistosomiasis 9.1 TNF IL5 IL4 IL10 IFNG CCL3
897 cutaneous leishmaniasis 9.1 TNF TLR9 TLR4 TLR2 IL5 IL4
898 immune system disease 9.1 TNF TLR9 TLR3 IL5 IL4 IL10
899 behcet syndrome 8.8 TNF TLR9 TLR4 MBL2 IL10 IFNG
900 trypanosomiasis 8.8 TNF TLR9 TLR2 IL4 IL10 IFNG
901 respiratory system disease 8.5 TNF TLR9 TLR4 SFTPD IL5 IL4
902 viral infectious disease 8.1 TNF TLR9 TLR3 IL4 IL10 IFNG

Comorbidity relations with Aspergillosis via Phenotypic Disease Network (PDN): (showing 6, show less)


Bronchiectasis Bronchitis
Deficiency Anemia Heart Disease
Postinflammatory Pulmonary Fibrosis Respiratory Failure

Graphical network of the top 20 diseases related to Aspergillosis:



Diseases related to Aspergillosis

Symptoms & Phenotypes for Aspergillosis

Clinical features from OMIM:

614079

UMLS symptoms related to Aspergillosis:


fever, pruritus

MGI Mouse Phenotypes related to Aspergillosis:

46 (showing 8, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.31 CCL17 CFTR CLEC7A ELANE IFNG IL10
2 immune system MP:0005387 10.22 CCL17 CFTR CLEC7A ELANE IFNG IL10
3 homeostasis/metabolism MP:0005376 10.21 CFTR CLEC7A ELANE IFNG IL10 IL4
4 digestive/alimentary MP:0005381 10.13 CFTR CLEC7A IFNG IL10 IL4 IL5
5 liver/biliary system MP:0005370 9.86 CFTR IFNG IL10 IL4 IL5 TLR2
6 neoplasm MP:0002006 9.76 ELANE IFNG IL10 IL5 TLR2 TLR3
7 reproductive system MP:0005389 9.61 CFTR IFNG IL10 IL4 IL5 PTX3
8 respiratory system MP:0005388 9.4 CFTR CLEC7A IFNG IL10 IL4 IL5

Drugs & Therapeutics for Aspergillosis

DrugBank drugs 16 :

(showing 2, show less)
# Drug Name Indication DrugBank ID
1 Itraconazole For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis. DB01167
2 Micafungin Indicated for the treatment of candidemia, acute disseminated candidiasis, and certain other invasive <i>Candida</i> infections, as well as esophageal candidiasis, and prophylaxis of <i>Candida</i> infections in patients undergoing hematopoietic stem cell transplantation. Micafungin is also used as an alternative for the treatment of oropharyngeal candidiases and has been used with some success as primary or salvage therapy, alone or in combination with other antifungals, for the treatment of invasive aspergillosis. Indicated for the prophylaxis of Candida infections in patients undergoing hematopoietic stem cell transplantation. DB01141

Drugs for Aspergillosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 117, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
2
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
3
Itraconazole Approved, Investigational Phase 4 84625-61-6 55283
4
Anidulafungin Approved, Investigational Phase 4 166663-25-8 166548
5
Omalizumab Approved, Investigational Phase 4 242138-07-4
6
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
7
Mycophenolic acid Approved Phase 4 24280-93-1 446541
8
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
9
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
10
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
11
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
12 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
13 Antitussive Agents Phase 4
14 Micronutrients Phase 4
15 Trace Elements Phase 4
16 Vitamin D2 Phase 4
17 Vitamins Phase 4
18 Ergocalciferols Phase 4
19 Nutrients Phase 4
20 Calciferol Phase 4
21 Calcium, Dietary Phase 4
22 Bone Density Conservation Agents Phase 4
23 Immunoglobulin G Phase 4
24 Immunologic Factors Phase 4
25 Liposomal amphotericin B Phase 4
26 Anti-Bacterial Agents Phase 4
27
Hydroxyitraconazole Phase 4
28 Anti-Allergic Agents Phase 4
29 Respiratory System Agents Phase 4
30 Immunoglobulin E Phase 4
31 Antibodies Phase 4
32 Immunoglobulins Phase 4
33 Anti-Asthmatic Agents Phase 4
34 Cytochrome P-450 CYP2C9 Inhibitors Phase 4
35 glucocorticoids Phase 4
36 Pharmaceutical Solutions Phase 4
37
Midazolam Approved, Illicit Phase 2, Phase 3 59467-70-8 4192
38
deoxycholic acid Approved Phase 3 83-44-3 222528
39
Budesonide Approved Phase 2, Phase 3 51333-22-3 63006 5281004
40
Natamycin Approved Phase 3 7681-93-8 5281099
41
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
42
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
43
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
44
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
45
Fluticasone Approved, Experimental Phase 2, Phase 3 90566-53-3 62924
46
Pirfenidone Approved, Investigational Phase 2, Phase 3 53179-13-8 40632
47
Prednisolone hemisuccinate Experimental Phase 2, Phase 3 2920-86-7
48 Ophthalmic Solutions Phase 2, Phase 3
49 Amphotericin B, deoxycholate drug combination Phase 3
50 Cholagogues and Choleretics Phase 3
51 Neurotransmitter Agents Phase 2, Phase 3
52 Adrenergic Agonists Phase 2, Phase 3
53 Adrenergic beta-Agonists Phase 2, Phase 3
54 Adrenergic beta-2 Receptor Agonists Phase 2, Phase 3
55 Adrenergic Agents Phase 2, Phase 3
56 Autonomic Agents Phase 2, Phase 3
57 Antiemetics Phase 2, Phase 3
58 Neuroprotective Agents Phase 2, Phase 3
59 Protective Agents Phase 2, Phase 3
60 Anti-Infective Agents, Local Phase 3
61 Prednisolone acetate Phase 2, Phase 3
62 Methylprednisolone Acetate Phase 2, Phase 3
63 Anti-Inflammatory Agents Phase 2, Phase 3
64 Formoterol Fumarate Phase 2, Phase 3
65 Antineoplastic Agents, Hormonal Phase 2, Phase 3
66 Peripheral Nervous System Agents Phase 2, Phase 3
67 Antirheumatic Agents Phase 2, Phase 3
68 Analgesics Phase 2, Phase 3
69 Analgesics, Non-Narcotic Phase 2, Phase 3
70 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
71
Cytarabine Approved, Experimental, Investigational Phase 2 147-94-4, 65-46-3 6253
72
Isavuconazole Approved, Investigational Phase 2 241479-67-4
73 Immunosuppressive Agents Phase 2
74 Antimetabolites Phase 2
75 Antimetabolites, Antineoplastic Phase 2
76 Antibiotics, Antitubercular Phase 2
77 interferons Phase 2
78 Interferon-gamma Phase 2
79 Antiviral Agents Phase 2
80 Echinocandins Phase 2
81 Antibodies, Monoclonal Phase 2
82
Rifampicin Approved Phase 1 13292-46-1 5381226 5458213
83
Fluconazole Approved, Investigational Phase 1 86386-73-4 3365
84 Tranquilizing Agents Phase 1
85 Anti-Anxiety Agents Phase 1
86 Adjuvants, Anesthesia Phase 1
87 GABA Agents Phase 1
88 Hypnotics and Sedatives Phase 1
89 GABA Modulators Phase 1
90 Central Nervous System Depressants Phase 1
91 Anesthetics Phase 1
92 Psychotropic Drugs Phase 1
93 Anesthetics, General Phase 1
94 Anesthetics, Intravenous Phase 1
95 Cytochrome P-450 CYP2C19 Inhibitors Phase 1
96
Coal tar Approved 8007-45-2
97
Petrolatum Approved, Investigational Early Phase 1 8009-03-8
98
Histamine Approved, Investigational 51-45-6 774
99
Sodium citrate Approved, Investigational 68-04-2
100
Esomeprazole Approved, Investigational 119141-88-7, 161796-78-7, 161973-10-0 9568614 4594
101
Ranitidine Approved 66357-35-5, 66357-59-3 3001055
102
Chloramphenicol Approved, Vet_approved 56-75-7 298 5959
103
Chloramphenicol succinate Approved 3544-94-3
104
Caspofungin Approved 179463-17-3, 162808-62-0 468682 2826718
105
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
106 Citrate
107 Histamine Antagonists
108
Histamine Phosphate 51-74-1 65513
109 Histamine H2 Antagonists