MCID: ASP006
MIFTS: 66

Aspergillosis

Categories: Genetic diseases, Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Aspergillosis

MalaCards integrated aliases for Aspergillosis:

Name: Aspergillosis 56 12 74 52 58 54 42 3 43 15 17 71 32
Aspergillosis, Susceptibility to 56 29 13 6 39
Infection Due to Aspergillus 12

Characteristics:

Orphanet epidemiological data:

58
aspergillosis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:13564
OMIM 56 614079
ICD9CM 34 117.3
MeSH 43 D001228
NCIt 49 C2886
SNOMED-CT 67 65553006
ICD10 32 B44 B44.9
MESH via Orphanet 44 D001228
ICD10 via Orphanet 33 B44.0 B44.1 B44.2 more
UMLS via Orphanet 72 C0004030
Orphanet 58 ORPHA1163
UMLS 71 C0004030

Summaries for Aspergillosis

NIH Rare Diseases : 52 Aspergillosis is an infection, growth, or allergic response caused by the Aspergillus fungus. There are several different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue . Another kind of aspergillosis is invasive aspergillosis. This infection usually affects people with weakened immune systems due to cancer , AIDS, leukemia, organ transplantation, chemotherapy , or other conditions or events that reduce the number of normal white blood cells . In this condition, the fungus invades and damages tissues in the body. Invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain). Aspergilloma , a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess , is a third kind of aspergillosis. This type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells . The fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas.

MalaCards based summary : Aspergillosis, also known as aspergillosis, susceptibility to, is related to allergic bronchopulmonary aspergillosis and invasive aspergillosis, and has symptoms including fever and pruritus. An important gene associated with Aspergillosis is CLEC1A (C-Type Lectin Domain Family 1 Member A), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Guaifenesin and Benralizumab have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and liver, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Disease Ontology : 12 An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney, heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system.

OMIM : 56 Aspergillus species are ubiquitous in nature and cause a wide spectrum of diseases, including saprophytic colonization of existing cavities (aspergilloma), allergic asthma, hypersensitivity pneumonitis, allergic bronchopulmonary aspergillosis, and disseminated disease associated with high mortality rates in patients with hematologic malignancies and recipients of solid organs and stem cell transplantations. Immunocompetent and nonatopic individuals are relatively resistant to infection, and disease occurs in the setting of host damage. Association of persistent inflammation with intractable infection is common in nonneutropenic patients after hematopoietic stem cell transplantation, as well as in allergic fungal diseases. The pathophysiology underlying Aspergillus infection highlights the bipolar nature of the inflammatory process in infection, in which early inflammation prevents or limits infection, but an uncontrolled response may oppose disease eradication (summary by Cunha et al., 2010). For information on familial occurrence of allergic bronchopulmonary aspergillosis, see 103920. (614079)

MedlinePlus : 42 Aspergillosis is a disease caused by a fungus (or mold) called Aspergillus. The fungus is very common in both indoors and outdoors. Most people breathe in the spores of the fungus every day without being affected. But some people get the disease. It usually occurs in people with lung diseases or weakened immune systems. There are different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA). Symptoms of ABPA include wheezing and coughing. ABPA can affect healthy people but it is most common in people with asthma or cystic fibrosis. Another kind is invasive aspergillosis, which damages tissues in the body. It usually affects the lungs. Sometimes it can also cause infection in other organs and spread throughout the body. It affects people who have immune system problems, such as people who have had a transplant, are taking high doses of steroids, or getting chemotherapy for some cancers. Your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, CT scan of the lungs, and an examination of tissues for signs of the fungus. Treatment is with antifungal drugs. If you have ABPA, you may also take steroids. Centers for Disease Control and Prevention

CDC : 3 Aspergillosis is an infection caused by Aspergillus, a common mold (a type of fungus) that lives indoors and outdoors. Most people breathe in Aspergillus spores every day without getting sick. However, people with weakened immune systems or lung diseases are at a higher risk of developing health problems due to Aspergillus. The types of health problems caused by Aspergillus include allergic reactions, lung infections, and infections in other organs.

Wikipedia : 74 Aspergillosis is the name given to a wide variety of diseases caused by fungal infections from species... more...

Related Diseases for Aspergillosis

Diseases in the Aspergillosis family:

Invasive Aspergillosis

Diseases related to Aspergillosis via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 956, show less)
# Related Disease Score Top Affiliating Genes
1 allergic bronchopulmonary aspergillosis 34.8 SFTPD MBL2 IL5 IL4 IL10 IFNG
2 invasive aspergillosis 33.8 TLR9 TLR6 TLR4 TLR2 SFTPD PTX3
3 neuroaspergillosis 33.0 TLR2 CLEC7A
4 neutropenia 32.1 MBL2 ELANE CSF3 CSF1
5 bronchiectasis 31.9 TLR2 MBL2 ELANE CFTR
6 hypereosinophilic syndrome 31.8 IL5 IL4 IL10 IFNG
7 mucormycosis 31.8 IFNG CSF3 CLEC7A CCR6
8 cystic fibrosis 31.6 TLR4 SFTPD MBL2 IL10 ELANE CFTR
9 chronic granulomatous disease 31.5 TLR9 IFNG ELANE CSF3
10 respiratory failure 31.4 SFTPD PTX3 IL5 IL10 ELANE CFTR
11 eosinophilic pneumonia 31.4 SFTPD IL5 IL4
12 rhinitis 31.4 IL5 IL4 IL10 IFNG
13 pulmonary tuberculosis 31.3 TLR4 TLR2 MBL2 IL4 IL10 IFNG
14 candidiasis 31.3 TLR4 TLR3 TLR2 MBL2 IL4 IL10
15 bronchopneumonia 31.3 TLR4 IL10 ELANE
16 acute graft versus host disease 31.2 IL4 IL10 IFNG CSF3
17 toxic shock syndrome 31.2 TLR4 TLR2 IL4 IL10 IFNG
18 ige responsiveness, atopic 31.2 IL5 IL4 IL10 IFNG
19 acquired immunodeficiency syndrome 31.2 IL10 IFNG CCR6 CCL3
20 cryptococcosis 31.2 MBL2 IL4 IL10 IFNG CLEC7A CCR6
21 osteomyelitis 31.2 TLR4 TLR2 IL4 IL10 IFNG CSF3
22 endocarditis 31.2 TLR6 TLR2 IL10 IFNG
23 sarcoidosis 1 31.1 SFTPD IFNG CCR6 CCL3
24 idiopathic interstitial pneumonia 31.1 TLR9 SFTPD IL4 IFNG ELANE CCR6
25 leukemia, acute myeloid 31.1 IL4 IL10 ELANE CSF3 CSF1 CCR6
26 bronchitis 31.0 TLR4 TLR2 IL5 IL4 IL10 ELANE
27 pneumocystosis 31.0 SFTPD CSF3 CLEC7A CCR6
28 histoplasmosis 31.0 IFNG CLEC7A CCR6
29 immune deficiency disease 31.0 MBL2 IL4 IL10 IFNG CCR6 CCL3
30 spondylitis 31.0 IL10 IFNG CCR6
31 lymphopenia 31.0 IL4 IL10 IFNG CCR6
32 bronchiolitis obliterans 30.9 TLR4 SFTPD IL10 IFNG
33 aplastic anemia 30.9 TLR9 IL4 IL10 IFNG CSF3 CSF1
34 chronic graft versus host disease 30.9 IL10 IFNG
35 allergic rhinitis 30.9 IL5 IL4 IL10 IFNG
36 pulmonary eosinophilia 30.9 SFTPD IL5 IL4 CCL3
37 chronic eosinophilic pneumonia 30.8 IL5 CSF3 CCL3
38 interstitial lung disease 30.8 SFTPD IL5 IL4 IL10 IFNG
39 coccidioidomycosis 30.8 TLR4 MBL2 CLEC7A CCR6
40 pyelonephritis 30.8 TLR4 MBL2 IL10 IFNG CSF3
41 echinococcosis 30.8 TLR4 TLR2 IL5 IL10 IFNG
42 exanthem 30.8 IL10 CSF3 CCR6
43 diarrhea 30.8 TLR4 IL5 IL10 IFNG CSF3 CFTR
44 fungal keratitis 30.8 TLR4 TLR2 CLEC7A
45 myocarditis 30.8 TLR4 TLR3 IL4 IL10 IFNG
46 extrinsic allergic alveolitis 30.7 SFTPD IL10 ELANE CCR6 CCL3
47 neuritis 30.7 IL4 IL10 IFNG CCL3
48 silicosis 30.7 TLR4 SFTPD IL4 IL10
49 thrombocytopenia 30.7 TLR9 TLR4 TLR2 IL4 IL10 IFNG
50 cellulitis 30.7 IL5 IL10 CCR6
51 allergic asthma 30.7 TLR4 TLR2 IL5 IL4 IL10 IFNG
52 pulmonary disease, chronic obstructive 30.7 TLR4 TLR2 SFTPD IL5 IL4 IL10
53 adult respiratory distress syndrome 30.7 SFTPD IL10 ELANE CSF3
54 pulmonary sarcoidosis 30.7 SFTPD IFNG CCR6 CCL3
55 stevens-johnson syndrome/toxic epidermal necrolysis 30.7 TLR9 IL5 IFNG
56 pulmonary alveolar proteinosis 30.7 SFTPD IL10 CSF1
57 otitis media 30.6 TLR4 TLR2 MBL2 IL5 IL4 IL10
58 lung disease 30.6 TLR9 TLR4 TLR2 SFTPD MBL2 IL5
59 esophagitis 30.6 IL5 IL4 IL10
60 allergic hypersensitivity disease 30.6 TLR9 TLR4 TLR2 SFTPD IL5 IL4
61 crohn's disease 30.6 TLR9 TLR4 TLR2 IL4 IL10 IFNG
62 status asthmaticus 30.6 IL5 IL10 ELANE
63 septic arthritis 30.6 TLR9 TLR4 TLR3 TLR2 IFNG
64 glomerulonephritis 30.6 TLR9 MBL2 ELANE CSF1
65 peritonitis 30.6 TLR4 TLR2 IL4 IL10 IFNG ELANE
66 melioidosis 30.6 TLR4 TLR2 IL10 IFNG CSF3
67 mycobacterium abscessus 30.6 TLR2 CLEC7A CFTR
68 ulcerative colitis 30.6 TLR4 IL4 IL10 IFNG CCR6
69 tetanus 30.6 IL5 IL4 IL10 IFNG
70 alcoholic hepatitis 30.5 TLR9 TLR4 TLR2 IL10
71 granulomatosis with polyangiitis 30.5 TLR9 TLR4 TLR2 IL5 ELANE CCR6
72 lepromatous leprosy 30.5 TLR2 IL4 IL10 IFNG
73 viral pneumonia 30.5 TLR3 SFTPD IL10
74 pleurisy 30.5 TLR4 TLR2 IFNG CCL3
75 acute cystitis 30.5 TLR4 TLR2 IL10 CCR6
76 combined t cell and b cell immunodeficiency 30.5 IL4 IL10 CCR6
77 acute pancreatitis 30.5 TLR4 IL10 ELANE CFTR
78 colitis 30.5 TLR9 TLR4 TLR2 IL4 IL10 IFNG
79 dengue hemorrhagic fever 30.4 TLR3 IL4 IL10 IFNG
80 dermatophytosis 30.4 CSF1 CLEC7A CCR6
81 autoimmune disease 30.4 TLR9 MBL2 IL5 IL4 IL10 IFNG
82 proliferative glomerulonephritis 30.4 IL4 IFNG CCL3
83 b cell deficiency 30.4 IL4 IL10 CCR6
84 trichinosis 30.4 IL5 IL4 IL10
85 paranasal sinus disease 30.4 IL5 IL4 IL10 IFNG CFTR CCR6
86 endomyocardial fibrosis 30.4 IL5 IL4 IL10
87 alcoholic liver cirrhosis 30.4 TLR4 TLR2 IL10
88 cryptosporidiosis 30.4 TLR4 MBL2 CSF3
89 conjunctivitis 30.3 TLR3 IL5 IL4 IL10 IFNG
90 eosinophilic gastroenteritis 30.3 IL5 IL4 CSF3
91 typhoid fever 30.3 TLR4 IFNG CFTR CCR6
92 amebiasis 30.3 TLR4 TLR2 IL4
93 appendicitis 30.3 TLR4 IL10 IFNG CSF3
94 dermatitis 30.3 TLR9 TLR4 TLR2 IL5 IL4 IL10
95 erythema multiforme 30.3 IL5 IL4 IFNG
96 food allergy 30.3 TLR4 TLR2 IL5 IL4 IL10 IFNG
97 mycobacterium tuberculosis 1 30.3 TLR9 TLR4 TLR2 MBL2 IL4 IL10
98 systemic scleroderma 30.3 SFTPD IL4 IFNG CCR6
99 keratitis, hereditary 30.3 TLR9 TLR4 TLR3 TLR2 IL10 CCR6
100 hyper ige recurrent infection syndrome 1 30.3 IL10 CLEC7A CCR6
101 elephantiasis 30.3 IL5 IL4 IL10 ELANE
102 collagen disease 30.3 IL4 IL10 CCR6
103 meningitis 30.2 TLR9 TLR4 TLR2 MBL2 IL5 IL4
104 severe acute respiratory syndrome 30.2 MBL2 IL10 IFNG
105 peripheral nervous system disease 30.2 TLR4 TLR2 IL4 IL10 IFNG CSF3
106 castleman disease 30.2 IL5 IL4 IL10 IFNG CSF3
107 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 30.2 IL4 IL10 CCR6
108 primary biliary cirrhosis 30.2 TLR9 TLR4 TLR3 MBL2 IL4 IL10
109 dengue disease 30.2 MBL2 CCR6 CCL3
110 paracoccidioidomycosis 30.2 TLR4 TLR2 IL5 IL4 IL10 IFNG
111 leptospirosis 30.2 TLR2 PTX3 IL4 IL10 IFNG
112 filarial elephantiasis 30.2 TLR4 TLR2 IL5 IL4 IL10
113 plasmodium falciparum malaria 30.2 IL4 IL10 IFNG
114 folliculitis 30.2 IL5 IL4 IFNG CCR6
115 nontuberculous mycobacterial lung disease 30.2 TLR2 CFTR
116 posterior uveitis 30.2 IL5 IL4 IFNG CCR6
117 toxic pneumonitis 30.2 TLR6 TLR4
118 esophagitis, eosinophilic, 1 30.2 IL5 IL4 CCR6
119 ileus 30.2 IL10 IFNG CFTR
120 bacterial pneumonia 30.1 TLR9 TLR4 TLR3 TLR2 SFTPD IL10
121 burkitt lymphoma 30.1 TLR9 IL4 IL10 CSF3 CCL3
122 listeriosis 30.1 TLR4 TLR2 MBL2 IL10 CCR6
123 aphthous stomatitis 30.1 TLR4 TLR2 IL5 IL4 IL10 IFNG
124 chromoblastomycosis 30.1 IL4 CLEC7A CCR6 CCL3
125 cutaneous t cell lymphoma 30.1 IL5 IL4 IFNG CCR6
126 connective tissue disease 30.1 TLR4 TLR2 SFTPD IL4 IL10 IFNG
127 aseptic meningitis 30.1 IL10 IFNG CSF3 CSF1 CCL3
128 hepatitis b 30.1 TLR4 TLR3 TLR2 MBL2 IFNG
129 bacterial meningitis 30.0 TLR9 TLR4 TLR2 MBL2 IL10 IFNG
130 gastroenteritis 30.0 TLR9 IL5 IL4 IL10 IFNG CSF3
131 measles 30.0 TLR9 TLR4 TLR3 TLR2 IFNG
132 severe combined immunodeficiency 30.0 IL5 IL4 IL10 IFNG CSF3 CSF1
133 leishmaniasis 30.0 TLR9 TLR4 TLR2 MBL2 IL5 IL4
134 middle ear disease 30.0 TLR9 TLR4 TLR2 IL10 CCR6
135 toxoplasmosis 30.0 TLR9 TLR4 TLR2 IL5 IL4 IL10
136 plague 30.0 TLR9 TLR6 TLR4 TLR2 IL10
137 opportunistic mycosis 29.9 TLR9 TLR6 TLR4 TLR3 TLR2 IL5
138 pulmonary edema 29.9 IL10 CSF3 CFTR
139 bronchiolitis 29.9 TLR9 TLR6 TLR4 TLR3 TLR2 SFTPD
140 chlamydia 29.9 TLR9 TLR4 TLR2 MBL2 IL4 IL10
141 bacterial sepsis 29.9 TLR9 TLR4 TLR3 TLR2 IL10 ELANE
142 pneumonia 29.9 TLR9 TLR6 TLR4 TLR2 SFTPD MBL2
143 common variable immunodeficiency 29.9 TLR9 TLR2 MBL2 IL5 IL4 IL10
144 myocardial infarction 29.9 TLR4 TLR2 PTX3 IL4 IL10 IFNG
145 proteasome-associated autoinflammatory syndrome 1 29.9 TLR6 TLR4 TLR2 IL5 IL4 IL10
146 tonsillitis 29.8 TLR9 TLR4 TLR3 TLR2 IL4 IL10
147 viral hepatitis 29.8 TLR9 TLR4 TLR3 TLR2 IL4 IL10
148 common cold 29.8 TLR4 TLR3 TLR2 IL5 IL4 IL10
149 bacterial infectious disease 29.8 TLR9 TLR4 TLR3 TLR2 PTX3 MBL2
150 perinatal necrotizing enterocolitis 29.8 TLR9 TLR6 TLR4 TLR3 TLR2 IL10
151 psoriasis 29.8 TLR9 TLR2 IL5 IL4 IL10 IFNG
152 myeloma, multiple 29.8 TLR9 TLR4 TLR3 IL4 IL10 IFNG
153 pulmonary fibrosis, idiopathic 29.6 TLR9 TLR4 TLR3 TLR2 SFTPD IL5
154 leprosy 3 29.6 TLR9 TLR6 TLR4 TLR3 TLR2 IL5
155 arthritis 29.5 TLR4 TLR2 IL4 IL10 IFNG CSF1
156 rheumatoid arthritis 29.5 TLR9 TLR4 TLR2 MBL2 IL4 IL10
157 systemic lupus erythematosus 29.5 TLR9 TLR4 TLR3 TLR2 PTX3 MBL2
158 salmonellosis 29.5 TLR9 TLR6 TLR4 TLR3 TLR2 IL10
159 bone disease 29.5 IL4 CSF1 CCR6 CCL3
160 dermatitis, atopic 29.4 TLR9 TLR6 TLR4 TLR3 TLR2 IL5
161 chronic mucocutaneous candidiasis 29.4 TLR3 TLR2 IL5 IL4 IL10 IFNG
162 coccidiosis 29.4 TLR9 TLR6 TLR4 TLR3 TLR2 IL4
163 malaria 29.2 TLR9 TLR6 TLR4 TLR2 MBL2 IL5
164 asthma 29.2 TLR9 TLR6 TLR4 TLR3 TLR2 SFTPD
165 multiple sclerosis 29.2 TLR9 TLR4 TLR3 TLR2 MBL2 IL5
166 inflammatory bowel disease 29.1 TLR9 TLR6 TLR4 TLR3 TLR2 IL5
167 allergic bronchopulmonary aspergillosis, familial 12.5
168 pulmonary aspergilloma 11.6
169 plastic bronchitis 11.5
170 tropical endomyocardial fibrosis 10.7 IL4 IL10
171 trichosporonosis 10.7 PTX3 CSF3 CLEC7A
172 prosthetic joint infection 10.7 TLR4 TLR2 MBL2
173 sporotrichosis 10.7 IL10 IFNG CLEC7A
174 eosinophilic fasciitis 10.7 IL5 IFNG
175 eales disease 10.7 IL4 IL10 IFNG
176 metal allergy 10.7 TLR4 IL4 IL10
177 atopic keratoconjunctivitis 10.7 IL5 IL4 IFNG
178 keratoconjunctivitis 10.7 IL5 IL4 IFNG
179 neisseria meningitidis infection 10.7 TLR4 TLR2 MBL2
180 toxic oil syndrome 10.7 IL5 IL4 IFNG
181 tularemia 10.7 TLR4 TLR2 MBL2
182 relapsing polychondritis 10.7 IL10 IFNG CSF3
183 pneumonic plague 10.7 TLR4 TLR2 IL10
184 penicillin allergy 10.7 IL4 IL10 IFNG
185 taeniasis 10.7 TLR4 IL4 IL10
186 corticosteroid allergy 10.7 IL5 IL4 IFNG
187 bone sarcoma 10.7 IL10 CSF3 CSF1
188 spotted fever rickettsiosis 10.6 IL10 IFNG
189 eosinophilic meningitis 10.6 IL5 IL4 IL10
190 cow milk allergy 10.6 IL5 IL4 IL10
191 milk allergy 10.6 IL5 IL4 IL10
192 trachoma 10.6 MBL2 IL4 IL10
193 urinary schistosomiasis 10.6 IL5 IL4 IFNG
194 poliomyelitis 10.6 IL4 IL10 IFNG
195 multicentric castleman disease 10.6 IL5 IL10 IFNG
196 scabies 10.6 MBL2 IL5 IL10 CSF3
197 hypersplenism 10.6 TLR4 IL4 IFNG CSF3
198 spondylarthropathy 10.6 TLR4 TLR2 CSF1
199 nickel allergic contact dermatitis 10.6 IL5 IL4 IL10 IFNG
200 allergic contact dermatitis 10.6 IL5 IL4 IL10 IFNG
201 extrapulmonary tuberculosis 10.6 TLR2 MBL2 IL10 IFNG
202 cystic echinococcosis 10.6 TLR4 TLR2 IL10 IFNG
203 rheumatic fever 10.6 TLR2 MBL2 IL10 IFNG
204 scrub typhus 10.6 TLR4 TLR2 IL10 IFNG
205 cutaneous candidiasis 10.6 TLR3 CLEC7A CCR6
206 brucellosis 10.6 TLR4 IL4 IL10 IFNG
207 rheumatic heart disease 10.6 TLR2 MBL2 IL4 IL10
208 silo filler's disease 10.6 TLR4 TLR2 SFTPD IL5
209 vernal conjunctivitis 10.6 IL4 IFNG CCR6
210 cerebral palsy 10.6 TLR4 MBL2 IL10 CSF3
211 aggressive periodontitis 10.6 TLR4 TLR2 IL4 IL10
212 dermatitis herpetiformis 10.6 IL5 IL4 IL10
213 neurosyphilis 10.6 TLR6 TLR2 IL10
214 inflammatory bowel disease 18 10.6 IL4 IL10 CCR6
215 african tick-bite fever 10.6 IL10 IFNG CCL3
216 pneumonic tularemia 10.6 TLR4 TLR2 CCR6
217 herpes zoster 10.6 TLR2 IL10 IFNG
218 hand, foot and mouth disease 10.6 TLR4 TLR3 IL10 IFNG
219 vogt-koyanagi-harada disease 10.6 TLR2 IL10 IFNG
220 meningococcal meningitis 10.6 TLR9 TLR4 TLR2 MBL2
221 subcutaneous mycosis 10.6 CLEC7A CLEC1A CCR6
222 acute leukemia 10.6
223 subacute sclerosing panencephalitis 10.6 TLR3 IL4 IL10 IFNG
224 central nervous system vasculitis 10.6 PTX3 IFNG CCR6
225 chest wall lymphoma 10.6 SFTPD CCR6
226 dental pulp disease 10.6 TLR4 TLR2 CCR6
227 b-cell growth factor 10.6 IL4 IFNG
228 autoimmune disease of eyes, ear, nose and throat 10.6 IL4 IL10 CCR6
229 cyclic neutropenia 10.6 IFNG ELANE CSF3 CSF1
230 chorioamnionitis 10.6 TLR4 IL4 IL10 ELANE
231 intermediate uveitis 10.6 IL10 IFNG CCR6
232 acute disseminated encephalomyelitis 10.6 IL10 CSF3 CCR6
233 progressive relapsing multiple sclerosis 10.6 PTX3 MBL2 CCR6
234 omenn syndrome 10.6 IL5 IL4 IL10 IFNG
235 lichen disease 10.6 IL4 IFNG CCR6
236 lymphocytic leukemia 10.6
237 myd88 deficiency 10.6 TLR6 TLR4 TLR2
238 irak4 deficiency 10.6 TLR6 TLR4 TLR2
239 mycoplasma pneumoniae pneumonia 10.6 TLR2 SFTPD IL4 IL10 IFNG
240 kawasaki disease 10.6 MBL2 IL4 IL10 ELANE
241 onchocerciasis 10.6 IL5 IL4 ELANE
242 tuberculoid leprosy 10.6 IL4 IL10 IFNG CCR6
243 pyelitis 10.6 TLR4 TLR2 CCR6
244 orofacial granulomatosis 10.5 IL4 IL10 IFNG CCL3
245 autoimmune vasculitis 10.5 IL4 ELANE CCR6
246 autoimmune gastritis 10.5 IL4 IL10 IFNG CCR6
247 lacrimal apparatus disease 10.5 IL4 IL10 CCR6
248 smallpox 10.5 IL4 IFNG CSF3
249 irritable bowel syndrome 10.5 TLR9 TLR4 TLR2 IL10
250 pustulosis palmaris et plantaris 10.5 IL5 ELANE CCR6
251 nut allergy 10.5 IL5 IL4 IL10 CCR6
252 autoimmune disease of endocrine system 10.5 IL4 IL10 IFNG CCR6
253 periapical granuloma 10.5 TLR2 IL4 CCL3
254 chronic fatigue syndrome 10.5 TLR4 IL5 IL4 IL10 IFNG
255 mikulicz disease 10.5 IL5 IL4 IL10 CCR6
256 scleritis 10.5 IL5 IL4 IFNG CCR6
257 haemophilus influenzae 10.5 TLR2 CLEC7A
258 vaginitis 10.5 TLR4 TLR2 IL10 CCR6
259 hashimoto thyroiditis 10.5 IL5 IL4 IL10 IFNG
260 egg allergy 10.5 IL5 IL4 IL10 CCR6
261 autoimmune uveitis 10.5 IL4 IL10 IFNG CCL3
262 chronic conjunctivitis 10.5 IL5 IL4 IL10 CCR6
263 genital herpes 10.5 TLR2 IL4 IL10 CCR6
264 uveal disease 10.5 IL4 IL10 IFNG CCR6
265 loiasis 10.5 IL5 IL4 IL10 CCL3
266 intestinal schistosomiasis 10.5 IL5 IL4 IL10 CCR6
267 fibrosis of extraocular muscles, congenital, 1 10.5
268 dysentery 10.5 TLR4 TLR2 IL10 CCR6
269 chlamydia pneumonia 10.5 TLR6 TLR4 TLR2 IL10
270 palladium allergic contact dermatitis 10.5 IL10 CCL3
271 hair disease 10.5 IL4 IL10 CSF3 CCR6
272 sebaceous gland disease 10.5 TLR4 TLR2 CCR6
273 latex allergy 10.5 IL5 IL4 IFNG CCL3
274 ileitis 10.5 TLR4 TLR2 IL10 CCR6
275 penile disease 10.5 TLR9 TLR4 TLR3 TLR2
276 lymphatic system disease 10.5 IL4 IL10 IFNG CCR6
277 secondary progressive multiple sclerosis 10.5 IL4 IL10 IFNG
278 iga glomerulonephritis 10.5 PTX3 MBL2 CCR6
279 respiratory syncytial virus infectious disease 10.5 IL5 CCL3
280 blau syndrome 10.5 TLR4 TLR2 IL4 IL10 CSF1
281 hepatitis a 10.5 TLR4 TLR3 IL4 IL10 IFNG
282 neuromuscular junction disease 10.5 IL4 IL10 CCR6
283 pelvic inflammatory disease 10.5 TLR6 TLR4 TLR2 IFNG
284 inflammatory bowel disease 1 10.5 TLR4 TLR2 CCR6
285 corneal disease 10.5 TLR4 TLR2 IL10 CCR6
286 allergic conjunctivitis 10.5 TLR3 IL5 IL4 IL10 IFNG
287 arteriosclerosis 10.5 TLR4 IL4 IL10 IFNG
288 familial mediterranean fever 10.5 TLR4 TLR2 IL10
289 stomatitis 10.5 TLR4 TLR2 IL4 IL10 IFNG CSF3
290 spastic paraplegia, intellectual disability, nystagmus, and obesity 10.5
291 hypotrichosis 1 10.5 IL4 IL10 CCR6
292 q fever 10.5 TLR4 TLR2 MBL2 IL4 IL10 IFNG
293 tropical spastic paraparesis 10.5 IL10 IFNG CCL3
294 lichen planus 10.5 IL4 IL10 IFNG
295 viral encephalitis 10.5 TLR3 IL10 CCR6
296 mumps 10.5 TLR3 IL10 IFNG
297 mucocutaneous leishmaniasis 10.5 TLR9 TLR3 IL4 IL10 IFNG
298 spondyloarthropathy 10.5 IL4 IL10 IFNG
299 autoimmune disease of gastrointestinal tract 10.5 TLR4 IL4 IL10 IFNG CCR6
300 granulocytopenia 10.5
301 peanut allergy 10.5 IL5 IL4 IL10 IFNG CCR6
302 tick-borne encephalitis 10.5 TLR3 IL10 CCL3
303 graft-versus-host disease 10.5
304 reactive arthritis 10.5 TLR4 TLR2 IL10 IFNG CCR6
305 acute pericementitis 10.5 TLR6 TLR2
306 lymphadenitis 10.5 TLR4 PTX3 IL10 IFNG CCR6
307 contact dermatitis 10.5 TLR4 TLR2 IL5 IL4 IL10 IFNG
308 leukemia, acute lymphoblastic 10.5
309 gingivitis 10.5 TLR2 IL4 IL10 IFNG ELANE CSF3
310 myeloid leukemia 10.5
311 sezary's disease 10.5 IL5 IL4 IL10 IFNG CCR6
312 yellow fever 10.5 IL5 IL4 CCR6
313 schistosomiasis 10.4 IL5 IL4 IL10 IFNG CCL3
314 leukocyte disease 10.4 IL5 IL4 IL10 CSF3 CCR6
315 periodontitis 10.4 TLR4 TLR2 IL4 IL10 IFNG ELANE
316 gingival disease 10.4 TLR4 TLR2 IL10 ELANE CCR6
317 bacterial vaginosis 10.4 TLR9 TLR4 TLR2 MBL2 IL4 IL10
318 visceral leishmaniasis 10.4 TLR9 TLR4 TLR2 IL4 IL10 IFNG
319 leukemia 10.4
320 rubella 10.4 TLR4 TLR3 IL5 IL4 IL10 IFNG
321 pneumothorax 10.4
322 vulvovaginal candidiasis 10.4 TLR2 MBL2 IL4 IFNG CLEC7A CCR6
323 mouth disease 10.4 TLR4 TLR3 IL10 IFNG CCR6
324 lymph node disease 10.4 TLR4 TLR2 IL4 IL10 IFNG CCR6
325 hypersensitivity reaction type iv disease 10.4 TLR4 TLR2 IL4 IL10 IFNG CCR6
326 pulmonary fibrosis 10.4
327 testicular disease 10.4 TLR4 TLR2 IL4 IL10 IFNG CCR6
328 rheumatic disease 10.4 SFTPD PTX3 MBL2 IL10 IFNG CCR6
329 sclerosing cholangitis 10.4 TLR4 IL10 CFTR
330 psoriatic arthritis 10.4 TLR4 TLR2 IL4 IL10 IFNG CCR6
331 autoimmune hepatitis type 1 10.4 IL4 IL10
332 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.4
333 chediak-higashi syndrome 10.4 IL4 IL10 CCR6
334 respiratory allergy 10.4 TLR4 TLR2 IL5 IL4 IL10 CCR6
335 superficial basal cell carcinoma 10.4 TLR9 TLR6 TLR4 TLR3 TLR2
336 combat disorder 10.4 TLR9 TLR6 TLR4 TLR3 TLR2
337 anogenital venereal wart 10.4 TLR9 TLR6 TLR4 TLR3 TLR2
338 lyme disease 10.4 TLR9 TLR6 TLR2 CCL3
339 mycetoma 10.4
340 cutaneous leishmaniasis 10.3 TLR9 TLR4 TLR2 IL5 IL4 IL10
341 primary systemic mycosis 10.3 TLR4 TLR2 IL4 IL10 IFNG CLEC7A
342 influenza 10.3
343 myelodysplastic syndrome 10.3
344 human immunodeficiency virus type 1 10.3
345 chickenpox 10.3 TLR9 TLR3 IL4 IL10 IFNG CCR6
346 oral cavity cancer 10.3 TLR6 TLR2 IL4 CCR6
347 relapsing-remitting multiple sclerosis 10.3 TLR4 IL4 IL10 IFNG CCR6 CCL3
348 anus disease 10.3 TLR9 TLR4 TLR3 TLR2 IL10 CCR6
349 exophthalmos 10.3
350 endometrial disease 10.3 TLR9 TLR6 TLR4 TLR3 TLR2 IL10
351 liver cirrhosis 10.3
352 splenic disease 10.3 TLR9 TLR4 TLR2 IL4 IL10 IFNG
353 eye disease 10.3 TLR4 TLR2 IL5 IL4 IL10 IFNG
354 demyelinating disease 10.3 IL4 IL10 IFNG CSF1 CCR6 CCL3
355 vasculitis 10.3
356 conjunctival disease 10.3 TLR4 TLR3 TLR2 IL5 IL4 IL10
357 filariasis 10.3 TLR9 TLR6 TLR4 TLR2 IL5 IL10
358 neutropenia, severe congenital, 3, autosomal recessive 10.2 ELANE CSF3
359 osteoporosis 10.2 TLR4 IL4 IL10 IFNG CSF1 CFTR
360 pleural empyema 10.2
361 endophthalmitis 10.2
362 extrinsic cardiomyopathy 10.2 TLR9 TLR4 TLR3 TLR2 IL4 IL10
363 kearns-sayre syndrome 10.2
364 cytokine deficiency 10.2
365 skin disease 10.2 TLR4 TLR2 SFTPD IL5 IL4 IL10
366 streptococcus pneumonia 10.2 TLR9 TLR6 TLR4 TLR3 TLR2 IL4
367 lung cancer 10.2
368 lupus erythematosus 10.2
369 human immunodeficiency virus infectious disease 10.2 TLR9 MBL2 IL4 IL10 IFNG CCR6
370 acute kidney failure 10.2
371 47,xyy 10.2
372 nasal cavity disease 10.2 TLR9 TLR4 TLR2 IL5 IL4 IL10
373 parasitic helminthiasis infectious disease 10.2 TLR9 TLR4 TLR2 IL5 IL4 IL10
374 purpura 10.2
375 ptosis 10.2
376 rare surgical neurologic disease 10.2
377 commensal bacterial infectious disease 10.2 TLR9 TLR4 TLR3 TLR2 IL4 IL10
378 inflammatory spondylopathy 10.2
379 headache 10.2
380 autoimmune disease of central nervous system 10.2 TLR9 TLR4 TLR3 TLR2 IL4 IL10
381 cytomegalovirus infection 10.1
382 rectal disease 10.1 TLR9 TLR6 TLR4 TLR3 TLR2 IL10
383 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
384 lymphoma 10.1
385 lung abscess 10.1
386 maxillary sinusitis 10.1
387 soft tissue sarcoma 10.1 IFNG CSF3
388 leukemia, chronic lymphocytic 10.1
389 pneumoconiosis 10.1
390 anthracosis 10.1
391 pancytopenia 10.1
392 nocardiosis 10.1
393 churg-strauss syndrome 10.1
394 acute liver failure 10.1
395 trypanosomiasis 10.1 TLR9 TLR6 TLR4 TLR2 IL4 IL10
396 chagas disease 10.1 TLR9 TLR6 TLR4 TLR2 IL4 IL10
397 spondyloarthropathy 1 10.1
398 ocular motor apraxia 10.1
399 deficiency anemia 10.1
400 meningoencephalitis 10.1
401 hypokalemia 10.1
402 kidney disease 10.1
403 paraplegia 10.1
404 pulmonary sequestration 10.1
405 vaginal disease 10.1 TLR9 TLR6 TLR4 TLR3 TLR2 IL10
406 nose disease 10.1 TLR9 TLR4 TLR3 TLR2 IL5 IL4
407 hypertension, essential 10.1 TLR9 TLR6 TLR4 TLR3 TLR2 IL4
408 upper respiratory tract disease 10.1 TLR9 TLR4 TLR3 TLR2 IL5 IL4
409 alcohol dependence 10.1
410 thrombocytopenic purpura, autoimmune 10.1
411 leukemia, chronic myeloid 10.1
412 fusariosis 10.1
413 optic nerve disease 10.1
414 actinomycosis 10.1
415 neuropathy 10.1
416 aneurysm 10.1
417 herpangina 10.1 TLR9 TLR6 TLR4 TLR3 TLR2 IL4
418 lung cancer susceptibility 3 10.0
419 thrombosis 10.0
420 amyloidosis 10.0
421 homologous wasting disease 10.0
422 pneumothorax, primary spontaneous 10.0
423 small cell cancer of the lung 10.0
424 temporal arteritis 10.0
425 yemenite deaf-blind hypopigmentation syndrome 10.0
426 diabetes mellitus, ketosis-prone 10.0
427 sphenoid sinusitis 10.0
428 farmer's lung 10.0
429 pericarditis 10.0
430 hematologic cancer 10.0
431 encephalitis 10.0
432 48,xyyy 10.0
433 pituitary tumors 10.0
434 autoimmune disease of musculoskeletal system 10.0 TLR9 TLR6 TLR4 TLR3 TLR2 IL4
435 viral infectious disease 10.0 TLR9 TLR4 TLR3 TLR2 IL4 IL10
436 bone inflammation disease 10.0 TLR9 TLR6 TLR4 TLR3 TLR2 IL4
437 lymphoma, hodgkin, classic 10.0
438 aphasia 10.0
439 hyper ige syndrome 10.0
440 optic neuritis 10.0
441 b-cell lymphoma 10.0
442 end stage renal failure 10.0
443 mediastinitis 10.0
444 orbital disease 10.0
445 pulmonary embolism 10.0
446 scedosporiosis 10.0
447 diabetes mellitus, noninsulin-dependent 10.0 TLR9 TLR6 TLR4 TLR3 TLR2 IL4
448 diabetes mellitus, insulin-dependent 10.0 TLR9 TLR6 TLR4 TLR3 TLR2 IL4
449 body mass index quantitative trait locus 11 9.9 TLR9 TLR6 TLR4 TLR3 TLR2 SFTPD
450 enterocolitis 9.9
451 lymphoma, non-hodgkin, familial 9.9
452 pulmonary hypertension 9.9
453 penicilliosis 9.9
454 atrioventricular block 9.9
455 cardiac tamponade 9.9
456 uveitis 9.9
457 esophageal candidiasis 9.9
458 squamous cell carcinoma 9.9
459 middle lobe syndrome 9.9
460 adenocarcinoma 9.9
461 glioblastoma multiforme 9.9
462 hemolytic anemia 9.9
463 thyroiditis 9.9
464 pulmonary emphysema 9.9
465 allergic angiitis 9.9
466 immune system disease 9.9 TLR9 TLR6 TLR4 TLR3 TLR2 IL5
467 parasitic protozoa infectious disease 9.9 TLR9 TLR6 TLR4 TLR3 TLR2 IL5
468 primary bacterial infectious disease 9.9 TLR9 TLR6 TLR4 TLR3 TLR2 IL5
469 celiac disease 1 9.9 TLR9 TLR6 TLR4 TLR3 TLR2 IL5
470 renal cell carcinoma, nonpapillary 9.9
471 meningioma, radiation-induced 9.9
472 meningioma, familial 9.9
473 acute promyelocytic leukemia 9.9
474 cyanosis, transient neonatal 9.9
475 leukemia, acute lymphoblastic 3 9.9
476 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 9.9
477 diffuse large b-cell lymphoma 9.9
478 cardiac arrest 9.9
479 lymphoproliferative syndrome 9.9
480 neuroretinitis 9.9
481 hydrocephalus 9.9
482 spinal meningioma 9.9
483 autoimmune hepatitis 9.9
484 agammaglobulinemia 9.9
485 myelitis 9.9
486 central nervous system disease 9.9
487 retinitis 9.9
488 hyperglycemia 9.9
489 pyoderma 9.9
490 secretory meningioma 9.9
491 lymphoplasmacyte-rich meningioma 9.9
492 adenoma 9.9
493 cataract 9.9
494 nervous system disease 9.9
495 intracranial hypertension 9.9
496 fasciitis 9.9
497 polyarteritis nodosa 9.9
498 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 9.9
499 glioma 9.9
500 microscopic polyangiitis 9.9
501 dysphagia 9.9
502 glial tumor 9.9
503 argyria 9.9
504 pemphigus vulgaris, familial 9.8
505 anemia, autoimmune hemolytic 9.8
506 asthma-related traits 2 9.8
507 dengue shock syndrome 9.8
508 intracranial abscess 9.8
509 dermatomyositis 9.8
510 chronic meningitis 9.8
511 legionellosis 9.8
512 mastitis 9.8
513 thrombotic thrombocytopenic purpura 9.8
514 chronic maxillary sinusitis 9.8
515 orbital cellulitis 9.8
516 disseminated intravascular coagulation 9.8
517 epidural abscess 9.8
518 choroiditis 9.8
519 nephrotic syndrome 9.8
520 blastomycosis 9.8
521 dilated cardiomyopathy 9.8
522 phaeohyphomycosis 9.8
523 oral candidiasis 9.8
524 geotrichosis 9.8
525 hairy cell leukemia 9.8
526 laryngitis 9.8
527 cavernous sinus thrombosis 9.8
528 aortic aneurysm 9.8
529 liver disease 9.8
530 aortitis 9.8
531 cerebrovascular disease 9.8
532 lung lymphoma 9.8
533 neuroblastoma 9.8
534 hodgkin's lymphoma, lymphocytic-histiocytic predominance 9.8
535 pyoderma gangrenosum 9.8
536 megakaryocytic leukemia 9.8
537 hard palate cancer 9.8
538 pemphigus 9.8
539 diabetes mellitus 9.8
540 diabetes insipidus 9.8
541 dacryoadenitis 9.8
542 dacryocystitis 9.8
543 hansen's disease 9.8
544 encephalopathy 9.8
545 hypoxia 9.8
546 idiopathic bronchiectasis 9.8
547 behcet syndrome 9.7 TLR9 TLR6 TLR4 TLR3 TLR2 MBL2
548 gastroesophageal reflux 9.7
549 breast cancer 9.7
550 felty syndrome 9.7
551 leukemia, acute monocytic 9.7
552 strabismus 9.7
553 torticollis 9.7
554 tracheoesophageal fistula with or without esophageal atresia 9.7
555 triiodothyronine receptor auxiliary protein 9.7
556 osteogenic sarcoma 9.7
557 graves disease 1 9.7
558 wilms tumor 5 9.7
559 anorexia nervosa 9.7
560 kala-azar 1 9.7
561 hepatitis c virus 9.7
562 mycobacterium tuberculosis 2 9.7
563 hydrops, lactic acidosis, and sideroblastic anemia 9.7
564 adrenal cortical carcinoma 9.7
565 aspiration pneumonia 9.7
566 cutaneous lupus erythematosus 9.7
567 adult t-cell leukemia 9.7
568 peripheral t-cell lymphoma 9.7
569 follicular lymphoma 9.7
570 infective endocarditis 9.7
571 clostridium difficile colitis 9.7
572 hepatic veno-occlusive disease 9.7
573 angioimmunoblastic t-cell lymphoma 9.7
574 rickets 9.7
575 interstitial nephritis 9.7
576 strongyloidiasis 9.7
577 hemiplegia 9.7
578 prostatic hypertrophy 9.7
579 enophthalmos 9.7
580 ornithosis 9.7
581 hepatorenal syndrome 9.7
582 hemosiderosis 9.7
583 goiter 9.7
584 acoustic neuroma 9.7
585 tolosa-hunt syndrome 9.7
586 polyneuropathy 9.7
587 facial paralysis 9.7
588 papilledema 9.7
589 prostatitis 9.7
590 pleural disease 9.7
591 neuroma 9.7
592 constipation 9.7
593 hepatitis 9.7
594 papilloma 9.7
595 transitional cell carcinoma 9.7
596 antiphospholipid syndrome 9.7
597 rhabdomyosarcoma 9.7
598 carotid artery thrombosis 9.7
599 cranial nerve palsy 9.7
600 pituitary adenoma 9.7
601 gastritis 9.7
602 carcinosarcoma 9.7
603 pustulosis of palm and sole 9.7
604 skull base meningioma 9.7
605 large cell carcinoma 9.7
606 brain edema 9.7
607 pancreatitis 9.7
608 urinary tract obstruction 9.7
609 t-cell leukemia 9.7
610 laryngeal disease 9.7
611 hyperthyroidism 9.7
612 bullous pemphigoid 9.7
613 monocytic leukemia 9.7
614 herpes simplex 9.7
615 myeloid sarcoma 9.7
616 mechanical strabismus 9.7
617 hypopituitarism 9.7
618 cholangitis 9.7
619 necrotizing fasciitis 9.7
620 miliary tuberculosis 9.7
621 hemophilia 9.7
622 hypertrophic cardiomyopathy 9.7
623 sickle cell disease 9.7
624 acute monoblastic leukemia 9.7
625 autoimmune gastrointestinal dysmotility 9.7
626 cytomegalic inclusion disease 9.7
627 lymphosarcoma 9.7
628 mycobacterium malmoense 9.7
629 pleuroparenchymal fibroelastosis 9.7
630 polymyositis 9.7
631 recurrent respiratory papillomatosis 9.7
632 stenotrophomonas maltophilia infection 9.7
633 back pain 9.7
634 meningitis and encephalitis 9.7
635 seizure disorder 9.7
636 posttransplant acute limbic encephalitis 9.7
637 subacute cutaneous lupus erythematosus 9.7
638 virus-associated trichodysplasia spinulosa 9.7
639 myospherulosis 9.7
640 secondary pulmonary alveolar proteinosis 9.7
641 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 9.7
642 thrombotic microangiopathy 9.7
643 bronchial disease 9.7 TLR9 TLR6 TLR4 TLR3 TLR2 IL5
644 aortic aneurysm, familial abdominal, 1 9.6
645 neurofibromatosis, type ii 9.6
646 pfeiffer syndrome 9.6
647 atrial standstill 1 9.6
648 bladder cancer 9.6
649 hepatocellular carcinoma 9.6
650 leukocyte adhesion deficiency, type i 9.6
651 creutzfeldt-jakob disease 9.6
652 epidermoid cysts 9.6
653 hyper-ige recurrent infection syndrome 1, autosomal dominant 9.6
654 immunoglobulin e concentration, serum 9.6
655 kaposi sarcoma 9.6
656 lipomatosis, multiple 9.6
657 marfan syndrome 9.6
658 medulloblastoma 9.6
659 myositis 9.6
660 porphyria cutanea tarda 9.6
661 pulmonary hypertension, primary, 1 9.6
662 scleroderma, familial progressive 9.6
663 spinal arachnoiditis 9.6
664 tetralogy of fallot 9.6
665 thrombophilia due to thrombin defect 9.6
666 digeorge syndrome 9.6
667 trigeminal neuralgia 9.6
668 volvulus of midgut 9.6
669 wolff-parkinson-white syndrome 9.6
670 adrenocortical carcinoma, hereditary 9.6
671 chondrosarcoma 9.6
672 schopf-schulz-passarge syndrome 9.6
673 endocardial fibroelastosis 9.6
674 fanconi anemia, complementation group a 9.6
675 gaucher disease, type i 9.6
676 hemolytic uremic syndrome, atypical 1 9.6
677 hydrocephalus due to congenital stenosis of aqueduct of sylvius 9.6
678 nonarteritic anterior ischemic optic neuropathy 9.6
679 pancreatic cancer 9.6
680 reticulum cell sarcoma 9.6
681 agammaglobulinemia, x-linked 9.6
682 mcleod syndrome 9.6
683 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 9.6
684 pearson marrow-pancreas syndrome 9.6
685 prostatic hyperplasia, benign 9.6
686 budd-chiari syndrome 9.6
687 stroke, ischemic 9.6
688 langerhans cell histiocytosis 9.6
689 systemic lupus erythematosus 2 9.6
690 late-onset retinal degeneration 9.6
691 pars planitis 9.6
692 lymphangioleiomyomatosis 9.6
693 nasopharyngeal carcinoma 9.6
694 asthma-related traits 1 9.6
695 severe cutaneous adverse reaction 9.6
696 pulmonary alveolar proteinosis, acquired 9.6
697 intraocular pressure quantitative trait locus 9.6
698 candidiasis, familial, 4 9.6
699 gastric cancer 9.6
700 nail disorder, nonsyndromic congenital, 10 9.6
701 immunodeficiency 21 9.6
702 barrett esophagus 9.6
703 dengue virus 9.6
704 mannose-binding lectin deficiency 9.6
705 immunodeficiency 12 9.6
706 hyperprolactinemia 9.6
707 cholangiocarcinoma 9.6
708 hepatitis, fulminant viral 9.6
709 angina pectoris 9.6
710 adiaspiromycosis 9.6
711 hemophagocytic lymphohistiocytosis 9.6
712 kartagener syndrome 9.6
713 otomycosis 9.6
714 cryptogenic organizing pneumonia 9.6
715 selective igm deficiency disease 9.6
716 multinodular goiter 9.6
717 severe congenital neutropenia 9.6
718 small cell carcinoma 9.6
719 autosomal recessive disease 9.6
720 mantle cell lymphoma 9.6
721 t-cell large granular lymphocyte leukemia 9.6
722 hemorrhagic cystitis 9.6
723 large cell neuroendocrine carcinoma 9.6
724 inflammatory myofibroblastic tumor 9.6
725 apraxia 9.6
726 balo concentric sclerosis 9.6
727 paroxysmal nocturnal hemoglobinuria 9.6
728 tracheomalacia 9.6
729 pollen allergy 9.6
730 drug allergy 9.6
731 cryptococcal meningitis 9.6
732 cytomegalovirus retinitis 9.6
733 mucositis 9.6
734 chronic myelomonocytic leukemia 9.6
735 polycystic kidney disease 9.6
736 bronchiectasis 2 9.6
737 cerebral artery occlusion 9.6
738 pleomorphic lipoma 9.6
739 asbestosis 9.6
740 berylliosis 9.6
741 byssinosis 9.6
742 chronic leukemia 9.6
743 hypopyon 9.6
744 portal hypertension 9.6
745 frontal sinusitis 9.6
746 gastric ulcer 9.6
747 abducens nerve disease 9.6
748 cholesteatoma of middle ear 9.6
749 discitis 9.6
750 hydronephrosis 9.6
751 sarcoma 9.6
752 t cell deficiency 9.6
753 megacolon 9.6
754 cerebral arteritis 9.6
755 xanthogranulomatous pyelonephritis 9.6
756 hemopericardium 9.6
757 horner's syndrome 9.6
758 gestational diabetes 9.6
759 pericardial effusion 9.6
760 arachnoiditis 9.6
761 cough variant asthma 9.6
762 graves' disease 9.6
763 tinea pedis 9.6
764 hepatic coma 9.6
765 hemolytic-uremic syndrome 9.6
766 quadriplegia 9.6
767 leukostasis 9.6
768 carotid stenosis 9.6
769 relapsing fever 9.6
770 periventricular leukomalacia 9.6
771 hellp syndrome 9.6
772 crescentic glomerulonephritis 9.6
773 porphyria 9.6
774 klebsiella pneumonia 9.6
775 exocrine pancreatic insufficiency 9.6
776 neurosarcoidosis 9.6
777 cholestasis 9.6
778 eclampsia 9.6
779 obstructive jaundice 9.6
780 biliary atresia 9.6
781 panophthalmitis 9.6
782 acute closed-angle glaucoma 9.6
783 multiple cranial nerve palsy 9.6
784 bird fancier's lung 9.6
785 squamous cell papilloma 9.6
786 pleuropneumonia 9.6
787 suppurative thyroiditis 9.6
788 acute thyroiditis 9.6
789 pyuria 9.6
790 capillary leak syndrome 9.6
791 hypothyroidism 9.6
792 panniculitis 9.6
793 urticaria 9.6
794 ectropion 9.6
795 alcohol use disorder 9.6
796 thrombocytopenia due to platelet alloimmunization 9.6
797 pineoblastoma 9.6
798 cystitis 9.6
799 heart septal defect 9.6
800 cheilitis 9.6
801 toxic megacolon 9.6
802 vascular disease 9.6
803 neuroendocrine carcinoma 9.6
804 status epilepticus 9.6
805 gaucher's disease 9.6
806 trichomoniasis 9.6
807 cholecystitis 9.6
808 hyperostosis 9.6
809 intestinal perforation 9.6
810 thrombocytosis 9.6
811 colon adenocarcinoma 9.6
812 neonatal jaundice 9.6
813 splenic abscess 9.6
814 larynx cancer 9.6
815 nonspecific interstitial pneumonia 9.6
816 laryngeal squamous cell carcinoma 9.6
817 prostatic adenoma 9.6
818 primary hyperoxaluria 9.6
819 anuria 9.6
820 testicular cancer 9.6
821 astrocytoma 9.6
822 malignant glioma 9.6
823 papillary adenocarcinoma 9.6
824 oligodendroglioma 9.6
825 central nervous system lymphoma 9.6
826 aspiration pneumonitis 9.6
827 lipid pneumonia 9.6
828 embryonal rhabdomyosarcoma 9.6
829 ischemia 9.6
830 histiocytosis 9.6
831 carotid artery disease 9.6
832 cerebritis 9.6
833 skin carcinoma 9.6
834 mixed connective tissue disease 9.6
835 lactic acidosis 9.6
836 olfactory neuroblastoma 9.6
837 hermansky-pudlak syndrome 9.6
838 craniopharyngioma 9.6
839 lung squamous cell carcinoma 9.6
840 adrenal cortical adenocarcinoma 9.6
841 schneiderian carcinoma 9.6
842 multidrug-resistant tuberculosis 9.6
843 fungal gastritis 9.6
844 tick infestation 9.6
845 nail disease 9.6
846 syphilis 9.6
847 myopathy 9.6
848 spindle cell sarcoma 9.6
849 intracranial embolism 9.6
850 hepatitis e 9.6
851 uremia 9.6
852 extragonadal germ cell cancer 9.6
853 atrophic rhinitis 9.6
854 rapidly progressive glomerulonephritis 9.6
855 benign ependymoma 9.6
856 intrahepatic cholangiocarcinoma 9.6
857 ureteral obstruction 9.6
858 infertility 9.6
859 pulmonary coin lesion 9.6
860 bronchus adenoma 9.6
861 lung oat cell carcinoma 9.6
862 cellular ependymoma 9.6
863 acute t cell leukemia 9.6
864 hemoglobinuria 9.6
865 congestive heart failure 9.6
866 thyroid hyalinizing trabecular adenoma 9.6
867 transient hypogammaglobulinemia of infancy 9.6
868 transient hypogammaglobulinemia 9.6
869 pulmonary large cell neuroendocrine carcinoma 9.6
870 hepatoblastoma 9.6
871 refractory hairy cell leukemia 9.6
872 subacute thyroiditis 9.6
873 meningothelial meningioma 9.6
874 axonal neuropathy 9.6
875 monoclonal gammopathy of uncertain significance 9.6
876 active peptic ulcer disease 9.6
877 chronic kidney disease 9.6
878 carotid artery occlusion 9.6
879 cocaine abuse 9.6
880 chronic rhinitis 9.6
881 intestinal obstruction 9.6
882 rheumatoid arthritis interstitial lung disease 9.6
883 molluscum contagiosum 9.6
884 chorioretinitis 9.6
885 mitochondrial encephalomyopathy 9.6
886 pityriasis versicolor 9.6
887 macroglobulinemia 9.6
888 cleft lip 9.6
889 scotoma 9.6
890 fatty liver disease 9.6
891 ethmoid sinusitis 9.6
892 plasma cell leukemia 9.6
893 primary ciliary dyskinesia 9.6
894 dextrocardia 9.6
895 plantar fasciitis 9.6
896 toxocariasis 9.6
897 alopecia 9.6
898 chronic dacryocystitis 9.6
899 hypervitaminosis d 9.6
900 hypoglycemia 9.6
901 mitochondrial disorders 9.6
902 acute myeloblastic leukemia with maturation 9.6
903 acute myeloblastic leukemia without maturation 9.6
904 acute non lymphoblastic leukemia 9.6
905 anca-associated vasculitis 9.6
906 aspergillus niger infection 9.6
907 candida glabrata 9.6
908 catastrophic antiphospholipid syndrome 9.6
909 chromosomal triplication 9.6
910 cystic adenomatoid malformation of lung 9.6
911 fibrosing mediastinitis 9.6
912 fournier gangrene 9.6
913 germ cells tumors 9.6
914 idiopathic hypertrophic pachymeningitis 9.6
915 laryngocele 9.6
916 mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes 9.6
917 mycobacterium avium complex infections 9.6
918 mycobacterium fortuitum 9.6
919 mycobacterium kansasii 9.6
920 mycobacterium xenopi 9.6
921 post-transplant lymphoproliferative disease 9.6
922 primary central nervous system lymphoma 9.6
923 sinonasal undifferentiated carcinoma 9.6
924 splenomegaly 9.6
925 staphylococcal toxic shock syndrome 9.6
926 swyer-james syndrome 9.6
927 thiopurine s methyltranferase deficiency 9.6
928 tuberculous meningitis 9.6
929 cerebral aneurysms 9.6
930 head injury 9.6
931 paresthesia 9.6
932 spasticity 9.6
933 spinal cord injury 9.6
934 tremor 9.6
935 rare mycosis 9.6
936 asbestos intoxication 9.6
937 rapidly involuting congenital hemangioma 9.6
938 rare hereditary hemochromatosis 9.6
939 voriconazole toxicity 9.6
940 igg4-related pachymeningitis 9.6
941 eosinophilic colitis 9.6
942 erythema multiforme major 9.6
943 benign idiopathic neonatal seizures 9.6
944 obsolete: ehlers-danlos syndrome, fibronectinemic type 9.6
945 pik3ca-related overgrowth syndrome 9.6
946 staphylococcal scarlet fever 9.6
947 classic pyoderma gangrenosum 9.6
948 diffuse alveolar hemorrhage 9.6
949 discoid lupus erythematosus 9.6
950 rare tumor 9.6
951 rare disease in surgical orthopedic 9.6
952 cardiogenic shock 9.6
953 refractory anemia 9.6
954 intravascular large b-cell lymphoma 9.6
955 polyendocrinopathy 9.6
956 thyroid carcinoma 9.6

Comorbidity relations with Aspergillosis via Phenotypic Disease Network (PDN): (showing 6, show less)


Bronchiectasis Bronchitis
Deficiency Anemia Heart Disease
Postinflammatory Pulmonary Fibrosis Respiratory Failure

Graphical network of the top 20 diseases related to Aspergillosis:



Diseases related to Aspergillosis

Symptoms & Phenotypes for Aspergillosis

Clinical features from OMIM:

614079

UMLS symptoms related to Aspergillosis:


fever, pruritus

GenomeRNAi Phenotypes related to Aspergillosis according to GeneCards Suite gene sharing:

26 (showing 1, show less)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CCL3 CCR6 CLEC7A CSF1 CSF3 IL5

MGI Mouse Phenotypes related to Aspergillosis:

45 (showing 8, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.36 CCR6 CFTR CLEC7A CSF1 CSF3 ELANE
2 immune system MP:0005387 10.28 CCR6 CFTR CLEC7A CSF1 CSF3 ELANE
3 homeostasis/metabolism MP:0005376 10.24 CCR6 CFTR CLEC7A CSF1 ELANE IFNG
4 digestive/alimentary MP:0005381 10.09 CFTR CLEC7A IFNG IL10 IL4 IL5
5 liver/biliary system MP:0005370 9.86 CFTR CSF1 IFNG IL10 IL4 IL5
6 neoplasm MP:0002006 9.7 ELANE IFNG IL10 IL5 TLR2 TLR3
7 reproductive system MP:0005389 9.65 CFTR CSF1 IFNG IL10 IL4 IL5
8 respiratory system MP:0005388 9.4 CFTR CLEC7A CSF1 IFNG IL10 IL4

Drugs & Therapeutics for Aspergillosis

Drugs for Aspergillosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 112, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
2 Benralizumab Approved, Investigational Phase 4 1044511-01-4
3
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
4
Itraconazole Approved, Investigational Phase 4 84625-61-6 55283
5
Anidulafungin Approved, Investigational Phase 4 166663-25-8 166548
6
Omalizumab Approved, Investigational Phase 4 242138-07-4
7
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
8
Mycophenolic acid Approved Phase 4 24280-93-1 446541
9
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
10
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
11
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
12
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
13 Antitussive Agents Phase 4
14 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
15 Vitamins Phase 4
16 Trace Elements Phase 4
17 Micronutrients Phase 4
18 Nutrients Phase 4
19 Ergocalciferols Phase 4
20 Calciferol Phase 4
21 Calcium, Dietary Phase 4
22 Vitamin D2 Phase 4
23 Antibodies, Monoclonal Phase 4
24 Immunoglobulin G Phase 4
25 Immunologic Factors Phase 4
26 Anti-Bacterial Agents Phase 4
27 Liposomal amphotericin B Phase 4
28
Hydroxyitraconazole Phase 4
29 Anti-Asthmatic Agents Phase 4
30 Respiratory System Agents Phase 4
31 Immunoglobulin E Phase 4
32 Antibodies Phase 4
33 Anti-Allergic Agents Phase 4
34 Immunoglobulins Phase 4
35 Cytochrome P-450 CYP2C9 Inhibitors Phase 4
36 glucocorticoids Phase 4
37 Pharmaceutical Solutions Phase 4
38
Midazolam Approved, Illicit Phase 2, Phase 3 59467-70-8 4192
39
deoxycholic acid Approved Phase 3 83-44-3 222528
40
Budesonide Approved Phase 2, Phase 3 51333-22-3 63006 5281004
41
Natamycin Approved Phase 3 7681-93-8 5281099
42
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
43
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
44
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
45
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
46 Prednisolone acetate Approved, Vet_approved Phase 2, Phase 3 52-21-1
47
Fluticasone Approved, Experimental Phase 2, Phase 3 90566-53-3 62924
48
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
49
Pirfenidone Approved, Investigational Phase 2, Phase 3 53179-13-8 40632
50
Prednisolone hemisuccinate Experimental Phase 2, Phase 3 2920-86-7
51 Ophthalmic Solutions Phase 2, Phase 3
52 Cholagogues and Choleretics Phase 3
53 Amphotericin B, deoxycholate drug combination Phase 3
54 Adrenergic Agonists Phase 2, Phase 3
55 Neurotransmitter Agents Phase 2, Phase 3
56 Autonomic Agents Phase 2, Phase 3
57 Adrenergic beta-Agonists Phase 2, Phase 3
58 Adrenergic Agents Phase 2, Phase 3
59 Antiemetics Phase 2, Phase 3
60 Neuroprotective Agents Phase 2, Phase 3
61 Protective Agents Phase 2, Phase 3
62 Anti-Infective Agents, Local Phase 3
63 Methylprednisolone Acetate Phase 2, Phase 3
64 Formoterol Fumarate Phase 2, Phase 3
65 Antineoplastic Agents, Hormonal Phase 2, Phase 3
66 Anti-Inflammatory Agents Phase 2, Phase 3
67 Antirheumatic Agents Phase 2, Phase 3
68 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
69 Analgesics, Non-Narcotic Phase 2, Phase 3
70 Analgesics Phase 2, Phase 3
71
Cytarabine Approved, Experimental, Investigational Phase 2 147-94-4, 65-46-3 6253
72
Isavuconazole Approved, Investigational Phase 2 241479-67-4
73 Immunosuppressive Agents Phase 2
74 Antimetabolites Phase 2
75 Antibiotics, Antitubercular Phase 2
76 Antiviral Agents Phase 2
77 interferons Phase 2
78 Interferon-gamma Phase 2
79 Echinocandins Phase 2
80
Rifampicin Approved Phase 1 13292-46-1 5458213 5381226
81 Anti-Anxiety Agents Phase 1
82 Tranquilizing Agents Phase 1
83 Hypnotics and Sedatives Phase 1
84 Adjuvants, Anesthesia Phase 1
85 Anesthetics Phase 1
86 GABA Agents Phase 1
87 Anesthetics, General Phase 1
88 Psychotropic Drugs Phase 1
89 GABA Modulators Phase 1
90 Anesthetics, Intravenous Phase 1
91 Central Nervous System Depressants Phase 1
92
Coal tar Approved 8007-45-2
93
Petrolatum Approved, Investigational Early Phase 1 8009-03-8
94
Esomeprazole Approved, Investigational 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
95
Histamine Approved, Investigational 51-45-6 774