MCID: ASP004
MIFTS: 44

Asphyxia Neonatorum

Categories: Fetal diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Asphyxia Neonatorum

MalaCards integrated aliases for Asphyxia Neonatorum:

Name: Asphyxia Neonatorum 39 12 77 54 45 15 17 74
Asphyxia, in Liveborn Infant 12
Hypoxia, in Liveborn Infant 74
Postnatal Asphyxia 12
Hypoxia Neonatorum 54
Asphyxia - Birth 12
Birth Asphyxia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11088
ICD9CM 36 768.9
MeSH 45 D001238
SNOMED-CT 69 28314004
ICD10 34 P21 P84

Summaries for Asphyxia Neonatorum

MalaCards based summary : Asphyxia Neonatorum, also known as asphyxia, in liveborn infant, is related to cerebral palsy and hypoxia. An important gene associated with Asphyxia Neonatorum is WIZ (WIZ Zinc Finger), and among its related pathways/superpathways are PI Metabolism and FOXA2 and FOXA3 transcription factor networks. The drugs Tocopherol and Oxytocin have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and lung, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 77 Perinatal asphyxia, neonatal asphyxia or birth asphyxia is the medical condition resulting from... more...

Related Diseases for Asphyxia Neonatorum

Graphical network of the top 20 diseases related to Asphyxia Neonatorum:



Diseases related to Asphyxia Neonatorum

Symptoms & Phenotypes for Asphyxia Neonatorum

MGI Mouse Phenotypes related to Asphyxia Neonatorum:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 C9 MTM1 MTMR14 PIK3C2A TTN YME1L1
2 homeostasis/metabolism MP:0005376 9.32 ABCC8 C9 HADH MTM1 MTMR14 PIK3C2A

Drugs & Therapeutics for Asphyxia Neonatorum

Drugs for Asphyxia Neonatorum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 119)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tocopherol Approved, Investigational Phase 4 1406-66-2 14986
2
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Not Applicable 50-56-6 53477758 439302
3
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
4
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
5
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 54670067 5785
6 Tocotrienol Investigational Phase 4 6829-55-6
7 Antioxidants Phase 4,Phase 1,Phase 2
8 Tocopherols Phase 4
9 Nutrients Phase 4,Phase 2
10 Trace Elements Phase 4,Phase 2
11 Vitamins Phase 4,Phase 2
12 Tocotrienols Phase 4
13 Micronutrients Phase 4,Phase 2
14 Protective Agents Phase 4,Phase 1,Phase 2
15 Oxytocics Phase 4,Phase 3,Not Applicable
16 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
17 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2
18 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2
19 Neurotransmitter Agents Phase 4,Phase 1,Phase 2,Not Applicable
20 Analgesics Phase 4,Phase 2,Phase 3
21 Anesthetics, General Phase 4,Phase 1,Phase 2
22 Anesthetics, Intravenous Phase 4
23 Excitatory Amino Acid Antagonists Phase 4
24 Anesthetics, Dissociative Phase 4
25 Excitatory Amino Acids Phase 4
26
Alprostadil Approved, Investigational Phase 2, Phase 3,Phase 3 745-65-3 5280723 149351
27
Papaverine Approved, Investigational Phase 2, Phase 3 58-74-2, 61-25-6 4680
28
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 3 7487-88-9 24083
29
Progesterone Approved, Vet_approved Phase 2, Phase 3 57-83-0 5994
30
Dinoprostone Approved Phase 3,Not Applicable 363-24-6 5280360
31
Misoprostol Approved Phase 3,Not Applicable 59122-46-2 5282381
32
Azithromycin Approved Phase 3 83905-01-5 447043 55185
33
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
34 Platelet Aggregation Inhibitors Phase 2, Phase 3
35 Vasodilator Agents Phase 2, Phase 3,Phase 3,Phase 1
36 Hematinics Phase 2, Phase 3,Phase 3,Phase 1
37 Epoetin alfa Phase 2, Phase 3,Phase 3,Phase 1 113427-24-0
38 Parasympatholytics Phase 2, Phase 3
39 Drotaverin Phase 2, Phase 3
40 Autonomic Agents Phase 2, Phase 3,Phase 1
41 Phosphodiesterase Inhibitors Phase 2, Phase 3,Phase 1
42 Tocolytic Agents Phase 3
43 Anti-Arrhythmia Agents Phase 3
44 Hormones Phase 3,Phase 2
45 calcium channel blockers Phase 3
46 Calcium, Dietary Phase 3
47 Anticonvulsants Phase 3,Phase 2
48 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
49 17 alpha-Hydroxyprogesterone Caproate Phase 2, Phase 3
50 Estrogens Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 100)
# Name Status NCT ID Phase Drugs
1 Single High Dose Vitamin C, E in Severe Birth Asphyxia Completed NCT01743742 Phase 4 Vitamin E, Vitamin C
2 BRAIN - Home Intervention Trial Completed NCT00639184 Phase 4
3 Continued Versus Discontinued Oxytocin Stimulation of Labour Recruiting NCT02553226 Phase 4 Oxytocin;Placebo
4 Low-dose Ketamine and Postpartum Depression in Parturients With Prenatal Depression Not yet recruiting NCT03927378 Phase 4 Ketamine;Placebos
5 Labor Induction and Maternal BMI, Comparison of Different Pre-induction Cervical Ripening Methods Unknown status NCT02223949 Phase 2, Phase 3 PGE1 tablet
6 Oxygen Toxicity in the Resuscitation in Extremely Premature Infants Completed NCT00494702 Phase 3
7 Whole-Body Cooling for Birth Asphyxia in Term Infants Completed NCT00005772 Phase 3
8 Neonatal Resuscitation in Zambia Completed NCT00097097 Phase 3
9 Drotaverine to Shorten the Length of Labor Completed NCT01639027 Phase 2, Phase 3 Drotaverine;Placebo
10 Neuroprotective Role of Erythropoietin in Perinatal Asphyxia Completed NCT02002039 Phase 2, Phase 3 Erythropoietin
11 Magnesium Sulphate in Perinatal Asphyxia Completed NCT00553072 Phase 3 Magnesium sulphate;Normal saline
12 17OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triplet Pregnancies Completed NCT00163020 Phase 2, Phase 3 17-alpha-hydroxyprogesterone caproate injectable;Placebo
13 Misoprostol Labour Induction Study Completed NCT03489928 Phase 3 Oral Misoprostol;Vaginal Misoprostol;Dinoprostone
14 High-dose Erythropoietin for Asphyxia and Encephalopathy Recruiting NCT02811263 Phase 3 Normal saline placebo;Erythropoietin
15 Pre-delivery Administration of Azithromycin to Prevent Neonatal Sepsis & Death Recruiting NCT03199547 Phase 3 Azithromycin;Placebo Oral Tablet
16 Mechanical cervicAl ripeninG for Women With PrOlongedPregnancies Recruiting NCT02907060 Phase 3 Pharmacological cervical ripening
17 Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO) Unknown status NCT01913340 Phase 1, Phase 2 Erythropoietin;Normal saline
18 Erythropoietin in Infants With Hypoxic Ischemic Encephalopathy (HIE) Completed NCT00945789 Phase 1, Phase 2 Human recombinant erythropoietin
19 Safety and Efficacy of Topiramate in Neonates With Hypoxic Ischemic Encephalopathy Treated With Hypothermia Completed NCT01241019 Phase 2 Topiramate in newborns with hypoxic ischemic encephalopathy treated with therapeutic hypothermia
20 Systemic Hypothermia Improves Outcome of Hypoxic-Ischemic Encephalopathy Completed NCT00817401 Phase 1, Phase 2
21 Darbe Administration in Newborns Undergoing Cooling for Encephalopathy Completed NCT01471015 Phase 1, Phase 2 Darbepoetin alfa;Darbepoetin alfa;Placebo
22 Melatonin for Neuroprotection Following Perinatal Asphyxia Completed NCT02071160 Phase 1, Phase 2 Melatonin
23 Use of Omega-3 Fatty Acids for Perinatal Depression Completed NCT00402389 Phase 2 Omega-3 Fatty Acids (EPA plus DHA);Placebo
24 Neuroprotective Effects of Hypothermia Combined With Inhaled Xenon Following Perinatal Asphyxia Completed NCT00934700 Phase 1, Phase 2
25 A Study of 2-Iminobiotin in Neonates With Perinatal Asphyxia Terminated NCT01626924 Phase 2 2-Iminobiotin
26 Therapeutic Hypothermia for Severe Acute Pancreatitis Withdrawn NCT01794858 Phase 2
27 Neonatal Erythropoietin in Asphyxiated Term Newborns Completed NCT00719407 Phase 1 erythropoietin
28 Sober Network IPT for Perinatal Women With Comorbid Substance Use and Depression Completed NCT01550913 Phase 1
29 Sildenafil Administration to Treat Neonatal Encephalopathy Recruiting NCT02812433 Phase 1 Sildenafil;Ora-Blend
30 Safer Births - Reducing Perinatal Mortality Unknown status NCT01869582 Not Applicable
31 S100B as a Marker of Brain Injury of Preterm Infants Unknown status NCT02082535
32 Apgar-Score in Asphyxiated Infants Under Resuscitation Unknown status NCT01193751
33 Asphyxia at Birth : Causes and Neonatal Outcome Completed NCT03227536
34 Characterization of the Cord Blood Stem Cell in Situation of Neonatal Asphyxia Completed NCT01284673 Not Applicable
35 Asphyxia Associated Metabolite Biomarker Investigation (AAMBI) Completed NCT03354208
36 Naushero Feroze Neonatal Survival Project Completed NCT01350765 Not Applicable
37 First Breath: Neonatal Resuscitation in Developing Countries Completed NCT00136708 Not Applicable
38 Resident Training Enhanced by New Innovations: Teleintubation Completed NCT02572427 Not Applicable
39 Randomized Clinical Trial Assessing Laryngeal Mask Airway Versus Face-mask Ventilation in Neonatal Resuscitation Completed NCT02042118 Not Applicable
40 Intraosseous Infusion for Neonatal Asphyxiated Resuscitation Completed NCT01866358 Not Applicable
41 Does Placenta Pathology Predict Outcome of Neonates With Hypoxic Ischemic Encephalopathy?" Completed NCT03284528
42 Randomized Cluster Trial on Innovative and Standard Strategies for Neonatal Resuscitation Training (RCPNEOPERU Project) Completed NCT03210194 Not Applicable
43 Early or Late Cord Clamping in the Depressed Neonate Completed NCT02727517 Not Applicable
44 Evaluation of Two Strategies for Debriefing in the Development of Skills for Neonatal Resuscitation Completed NCT03606278 Not Applicable
45 Saving Lives at Birth in Uganda: Building and Sustaining Capacity of Frontline Health Workers - A Program Evaluation Completed NCT03254628 Not Applicable oxytocin and misoprostol
46 Brain Activity During Birth for Prediction of Newborns at Risk for Brain Injury Completed NCT02445417
47 Home Based Child Care to Reduce Mortality and Malnutrition in Tribal Children of Melghat, India: CRCT Completed NCT02473796 Not Applicable
48 Evaluating the Effects of SMS Text Messaging Support System Among Frontline Health Workers in Ghana Completed NCT02468310 Not Applicable
49 Infant Special Program for In Hospital Resuscitation Education in the Delivery Room Completed NCT02347241 Not Applicable
50 Introducing Fetal Scalp Stimulation as an Adjunct to Intermittent Auscultation in Low-Resource Settings. Completed NCT02862925 Not Applicable

Search NIH Clinical Center for Asphyxia Neonatorum

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Asphyxia Neonatorum cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Asphyxia Neonatorum:
Cord blood-derived hematopoietic stem cells for treatment of oxygen deprivation in newborns
Embryonic/Adult Cultured Cells Related to Asphyxia Neonatorum:
Umbilical cord blood-derived hematopoietic stem cells (family)

Cochrane evidence based reviews: asphyxia neonatorum

Genetic Tests for Asphyxia Neonatorum

Anatomical Context for Asphyxia Neonatorum

MalaCards organs/tissues related to Asphyxia Neonatorum:

42
Brain, Heart, Lung, Kidney, Liver, Placenta, Tongue

Publications for Asphyxia Neonatorum

Articles related to Asphyxia Neonatorum:

(show top 50) (show all 93)
# Title Authors Year
1
Human recombinant erythropoietin in asphyxia neonatorum: pilot trial. ( 20385632 )
2010
2
Defending a neurologic birth injury. Asphyxia neonatorum redux. ( 19499449 )
2009
3
Is it time to revisit a role for antithrombotic therapy in asphyxia neonatorum? ( 15080111 )
2004
4
Renal insult in asphyxia neonatorum. ( 11042710 )
2000
5
Hepatic profile in asphyxia neonatorum. ( 9567557 )
1997
6
Maternal factors contributing to asphyxia neonatorum. ( 8816028 )
1996
7
Myocardial changes in neonates dying of asphyxia neonatorum. ( 1344220 )
1992
8
Influence of maternal nutritional status on mode of delivery and asphyxia neonatorum. ( 1398866 )
1992
9
Foetal co-relates and mode of delivery in asphyxia neonatorum. ( 1937632 )
1991
10
ECG changes in asphyxia neonatorum. ( 2081640 )
1990
11
Asphyxia neonatorum. ( 3711811 )
1986
12
Definition and grading of asphyxia neonatorum. ( 3775608 )
1986
13
Myocardial ischaemia in asphyxia neonatorum. Electrocardiographic, enzymatic and histological correlations. ( 4024929 )
1985
14
Asphyxia neonatorum: a clinical evaluation of 60 affected infants. ( 1193708 )
1975
15
Management of asphyxia neonatorum. ( 1193711 )
1975
16
Asphyxia neonatorum--incidence in Cape Town. ( 4428302 )
1974
17
Neonatal complications and conditions associated with asphyxia neonatorum. ( 4432179 )
1974
18
Asphyxia neonatorum--assessment of the infant at birth. ( 4473836 )
1974
19
Asphyxia neonatorum--neurological status at one year follow-up. ( 4473837 )
1974
20
Letter: Asphyxia neonatorum. ( 4475487 )
1974
21
Asphyxia neonatorum. ( 4799713 )
1973
22
Asphyxia neonatorum caused by foaming. ( 4112571 )
1972
23
Hyponatremia following asphyxia neonatorum. ( 5448486 )
1970
24
Asphyxia neonatorum. ( 5529468 )
1970
25
Memory deficit in monkeys brain damaged by asphyxia neonatorum. ( 4979089 )
1969
26
Asphyxia neonatorum. ( 5587613 )
1967
27
Controlled trials of hyperbaric oxygen and tracheal intubation in asphyxia neonatorum. ( 4160515 )
1966
28
On the influence of abnormal parturition, difficult labours, premature birth, and asphyxia neonatorum, on the mental and physical condition of the child, especially in relation to deformities. ( 5950310 )
1966
29
The use of hyperbaric oxygen in asphyxia neonatorum and the respiratory distress syndrome. ( 6003308 )
1966
30
TREATMENT OF ASPHYXIA NEONATORUM BY HYPERBARIC OXYGENATION. ( 14252020 )
1965
31
ASPHYXIA NEONATORUM. ( 14116230 )
1964
32
HYPOTHERMIA IN THE TREATMENT OF ASPHYXIA NEONATORUM. ( 14136494 )
1964
33
[CHOLINESTERASE ACTIVITY OF THE BLOOD SERUM IN FETAL DEATH, ASPHYXIA NEONATORUM AND FETAL DEFORMITIES]. ( 14256126 )
1964
34
ASPHYXIA NEONATORUM. ( 14044048 )
1963
35
Hypothermia and transfusion with oxygenated blood in the treatment of asphyxia neonatorum. ( 14000132 )
1962
36
Structural and functional sequelae of asphyxia neonatorum in monkeys (Macaca mulatta). ( 14007461 )
1962
37
The weight of the heart of mature infants after asphyxia neonatorum. ( 13689151 )
1961
38
Effects of asphyxia neonatorum on behavior in the Rhesus monkey. ( 14497712 )
1961
39
Maternal and obstetric factors in asphyxia neonatorum with a preliminary report on a possible association with ABO blood groups. ( 13683009 )
1960
40
Brain damage in the monkey, macaca mulatta, by asphyxia neonatorum. ( 13663899 )
1959
41
An electronic resuscitator for possible use in asphyxia neonatorum. ( 13616412 )
1958
42
Neurological and psychological deficits from asphyxia neonatorum. ( 13441865 )
1957
43
Asphyxia neonatorum. ( 13479645 )
1957
44
Causation and treatment of asphyxia neonatorum. ( 13306743 )
1956
45
Asphyxia neonatorum. ( 13310418 )
1956
46
Management of asphyxia neonatorum. ( 13359430 )
1956
47
Pathological anatomy of asphyxia neonatorum. ( 13292256 )
1955
48
Asphyxia neonatorum: its clinical features and treatment. ( 13292258 )
1955
49
An experimental study of the human fetus with special reference to asphyxia neonatorum. ( 13292259 )
1955
50
The ultimate residual lesions of asphyxia neonatorum; with three cases of porencephaly. ( 14358884 )
1955

Variations for Asphyxia Neonatorum

Expression for Asphyxia Neonatorum

Search GEO for disease gene expression data for Asphyxia Neonatorum.

Pathways for Asphyxia Neonatorum

GO Terms for Asphyxia Neonatorum

Cellular components related to Asphyxia Neonatorum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 I band GO:0031674 8.96 MTM1 TTN
2 ruffle GO:0001726 8.8 MTM1 MTMR14 S100B

Biological processes related to Asphyxia Neonatorum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to insulin GO:0032868 9.26 ABCC8 HADH
2 regulation of insulin secretion GO:0050796 9.16 ABCC8 SLC16A1
3 negative regulation of insulin secretion GO:0046676 8.96 ABCC8 HADH
4 phosphatidylinositol biosynthetic process GO:0006661 8.8 MTM1 MTMR14 PIK3C2A

Molecular functions related to Asphyxia Neonatorum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-3-phosphatase activity GO:0004438 8.96 MTM1 MTMR14
2 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity GO:0052629 8.32 MTM1

Sources for Asphyxia Neonatorum

3 CDC
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9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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