MCID: ASP004
MIFTS: 43

Asphyxia Neonatorum

Categories: Rare diseases, Fetal diseases, Respiratory diseases

Aliases & Classifications for Asphyxia Neonatorum

MalaCards integrated aliases for Asphyxia Neonatorum:

Name: Asphyxia Neonatorum 38 12 76 53 44 15 73
Asphyxia, in Liveborn Infant 12
Hypoxia, in Liveborn Infant 73
Postnatal Asphyxia 12
Hypoxia Neonatorum 53
Asphyxia - Birth 12
Birth Asphyxia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11088
ICD10 33 P84 P21
ICD9CM 35 768.9
MeSH 44 D001238

Summaries for Asphyxia Neonatorum

MalaCards based summary : Asphyxia Neonatorum, also known as asphyxia, in liveborn infant, is related to acute mountain sickness and granulomatous myositis. An important gene associated with Asphyxia Neonatorum is WIZ (Widely Interspaced Zinc Finger Motifs), and among its related pathways/superpathways is PI Metabolism. The drugs Oxytocin and Tocopherol have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and lung, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 76 Perinatal asphyxia, neonatal asphyxia or birth asphyxia is the medical condition resulting from... more...

Related Diseases for Asphyxia Neonatorum

Diseases related to Asphyxia Neonatorum via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 acute mountain sickness 10.1 PIK3C2A S100B
2 granulomatous myositis 10.1 PIK3C2A TTN
3 hypoxia 10.0
4 hepatitis 10.0
5 nasopharyngitis 10.0
6 pertussis 10.0
7 teratoma 10.0
8 nasopharyngeal teratoma 10.0
9 cerebral palsy 9.9
10 dyskinetic cerebral palsy 9.9
11 cerebritis 9.9
12 hyperinsulinemic hypoglycemia 9.9 ABCC8 SLC16A1
13 bacterial meningitis 9.8 PIK3C2A S100B
14 centronuclear myopathy 9.6 MTM1 MTMR14 TTN
15 muscle tissue disease 9.2 MTM1 PIK3C2A
16 myopathy 8.9 MTM1 MTMR14 PIK3C2A TTN

Graphical network of the top 20 diseases related to Asphyxia Neonatorum:



Diseases related to Asphyxia Neonatorum

Symptoms & Phenotypes for Asphyxia Neonatorum

MGI Mouse Phenotypes related to Asphyxia Neonatorum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.7 SLC16A1 TTN KCNC3 MTM1 MTMR14 PIK3C2A
2 homeostasis/metabolism MP:0005376 9.61 TTN YME1L1 ABCC8 KCNC3 MTM1 MTMR14
3 muscle MP:0005369 9.02 TTN YME1L1 KCNC3 MTM1 MTMR14

Drugs & Therapeutics for Asphyxia Neonatorum

Drugs for Asphyxia Neonatorum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 110)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxytocin Approved, Vet_approved Phase 4,Not Applicable 50-56-6 439302 53477758
2
Tocopherol Approved, Investigational, Nutraceutical Phase 4 1406-66-2 14986
3
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
4
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
5 Antioxidants Phase 4,Phase 1,Phase 2
6 Micronutrients Phase 4,Phase 2
7 Protective Agents Phase 4,Phase 1,Phase 2
8 Tocopherols Phase 4
9 Tocotrienols Phase 4
10 Trace Elements Phase 4,Phase 2
11 Vitamins Phase 4,Phase 2
12 Oxytocics Phase 4,Phase 3,Not Applicable
13 Tocotrienol Investigational, Nutraceutical Phase 4 6829-55-6
14
Alprostadil Approved, Investigational Phase 2, Phase 3 745-65-3 149351 5280723
15
Papaverine Approved, Investigational Phase 2, Phase 3 61-25-6, 58-74-2 4680
16
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 3 7487-88-9 24083
17
Progesterone Approved, Vet_approved Phase 2, Phase 3 57-83-0 5994
18
Dinoprostone Approved Phase 3,Not Applicable 363-24-6 5280360
19
Azithromycin Approved Phase 3 83905-01-5 55185 447043
20 Platelet Aggregation Inhibitors Phase 2, Phase 3
21 Vasodilator Agents Phase 2, Phase 3,Phase 3,Phase 1
22 Epoetin alfa Phase 2, Phase 3,Phase 3,Phase 1 113427-24-0
23 Hematinics Phase 2, Phase 3,Phase 3,Phase 1
24 Analgesics Phase 2, Phase 3,Phase 3
25 Autonomic Agents Phase 2, Phase 3,Phase 1
26 Drotaverin Phase 2, Phase 3
27 Parasympatholytics Phase 2, Phase 3
28 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3,Phase 1
29 Phosphodiesterase Inhibitors Phase 2, Phase 3,Phase 1
30 Anesthetics Phase 3,Phase 1,Phase 2
31 Anti-Arrhythmia Agents Phase 3
32 Anticonvulsants Phase 3,Phase 2
33 calcium channel blockers Phase 3
34 Calcium, Dietary Phase 3
35 Central Nervous System Depressants Phase 3,Phase 1,Phase 2
36 Tocolytic Agents Phase 3
37 11-hydroxyprogesterone Phase 2, Phase 3
38 17-alpha-hydroxy-progesterone caproate Phase 2, Phase 3
39 Estrogen Antagonists Phase 2, Phase 3
40 Estrogens Phase 2, Phase 3
41 Hormone Antagonists Phase 2, Phase 3
42 Hormones Phase 2, Phase 3
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
44 Progestins Phase 2, Phase 3
45 Caproate Nutraceutical Phase 2, Phase 3
46
Nitric Oxide Approved Phase 1, Phase 2 10102-43-9 145068 160954
47
Topiramate Approved Phase 2 97240-79-4 5284627
48
Darbepoetin alfa Approved, Investigational Phase 1, Phase 2 11096-26-7, 209810-58-2
49
Melatonin Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 73-31-4 896
50
Biotin Approved, Investigational, Nutraceutical Phase 2 58-85-5 171548

Interventional clinical trials:

(show top 50) (show all 85)
# Name Status NCT ID Phase Drugs
1 Single High Dose Vitamin C, E in Severe Birth Asphyxia Completed NCT01743742 Phase 4 Vitamin E, Vitamin C
2 BRAIN - Home Intervention Trial Completed NCT00639184 Phase 4
3 Continued Versus Discontinued Oxytocin Stimulation of Labour Recruiting NCT02553226 Phase 4 Oxytocin;Placebo
4 Labor Induction and Maternal BMI, Comparison of Different Pre-induction Cervical Ripening Methods Unknown status NCT02223949 Phase 2, Phase 3 PGE1 tablet
5 Oxygen Toxicity in the Resuscitation in Extremely Premature Infants Completed NCT00494702 Phase 3
6 Neonatal Resuscitation in Zambia Completed NCT00097097 Phase 3
7 Whole-Body Cooling for Birth Asphyxia in Term Infants Completed NCT00005772 Phase 3
8 Drotaverine to Shorten the Length of Labor Completed NCT01639027 Phase 2, Phase 3 Drotaverine;Placebo
9 Neuroprotective Role of Erythropoietin in Perinatal Asphyxia Completed NCT02002039 Phase 2, Phase 3 Erythropoietin
10 Magnesium Sulphate in Perinatal Asphyxia Completed NCT00553072 Phase 3 Magnesium sulphate;Normal saline
11 17OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triplet Pregnancies Completed NCT00163020 Phase 2, Phase 3 17-alpha-hydroxyprogesterone caproate injectable;Placebo
12 Misoprostol Labour Induction Study Completed NCT03489928 Phase 3 Oral Misoprostol;Vaginal Misoprostol;Dinoprostone
13 High-dose Erythropoietin for Asphyxia and Encephalopathy Recruiting NCT02811263 Phase 3 Normal saline placebo;Erythropoietin
14 Pre-delivery Administration of Azithromycin to Prevent Neonatal Sepsis & Death Recruiting NCT03199547 Phase 3 Azithromycin;Placebo Oral Tablet
15 Mechanical cervicAl ripeninG for Women With PrOlongedPregnancies Recruiting NCT02907060 Phase 3 Pharmacological cervical ripening
16 Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO) Unknown status NCT01913340 Phase 1, Phase 2 Erythropoietin;Normal saline
17 Erythropoietin in Infants With Hypoxic Ischemic Encephalopathy (HIE) Completed NCT00945789 Phase 1, Phase 2 Human recombinant erythropoietin
18 Safety and Efficacy of Topiramate in Neonates With Hypoxic Ischemic Encephalopathy Treated With Hypothermia Completed NCT01241019 Phase 2 Topiramate in newborns with hypoxic ischemic encephalopathy treated with therapeutic hypothermia
19 Systemic Hypothermia Improves Outcome of Hypoxic-Ischemic Encephalopathy Completed NCT00817401 Phase 1, Phase 2
20 Darbe Administration in Newborns Undergoing Cooling for Encephalopathy Completed NCT01471015 Phase 1, Phase 2 Darbepoetin alfa;Darbepoetin alfa;Placebo
21 Melatonin for Neuroprotection Following Perinatal Asphyxia Completed NCT02071160 Phase 1, Phase 2 Melatonin
22 Use of Omega-3 Fatty Acids for Perinatal Depression Completed NCT00402389 Phase 2 Omega-3 Fatty Acids (EPA plus DHA);Placebo
23 Intermittent Auscultation Using Handheld Doppler: a Randomized Controlled Trial Comparing Perinatal Outcomes in Uganda Completed NCT02273037 Phase 2
24 Neuroprotective Effects of Hypothermia Combined With Inhaled Xenon Following Perinatal Asphyxia Completed NCT00934700 Phase 1, Phase 2
25 A Study of 2-Iminobiotin in Neonates With Perinatal Asphyxia Terminated NCT01626924 Phase 2 2-Iminobiotin
26 Therapeutic Hypothermia for Severe Acute Pancreatitis Withdrawn NCT01794858 Phase 2
27 Neonatal Erythropoietin in Asphyxiated Term Newborns Completed NCT00719407 Phase 1 erythropoietin
28 Sober Network IPT for Perinatal Women With Comorbid Substance Use and Depression Completed NCT01550913 Phase 1
29 Sildenafil Administration to Treat Neonatal Encephalopathy Recruiting NCT02812433 Phase 1 Sildenafil;Ora-Blend
30 S100B as a Marker of Brain Injury of Preterm Infants Unknown status NCT02082535
31 Apgar-Score in Asphyxiated Infants Under Resuscitation Unknown status NCT01193751
32 Asphyxia at Birth : Causes and Neonatal Outcome Completed NCT03227536
33 Characterization of the Cord Blood Stem Cell in Situation of Neonatal Asphyxia Completed NCT01284673 Not Applicable
34 Asphyxia Associated Metabolite Biomarker Investigation (AAMBI) Completed NCT03354208
35 Naushero Feroze Neonatal Survival Project Completed NCT01350765 Not Applicable
36 First Breath: Neonatal Resuscitation in Developing Countries Completed NCT00136708 Not Applicable
37 Resident Training Enhanced by New Innovations: Teleintubation Completed NCT02572427 Not Applicable
38 Randomized Clinical Trial Assessing Laryngeal Mask Airway Versus Face-mask Ventilation in Neonatal Resuscitation Completed NCT02042118 Not Applicable
39 Intraosseous Infusion for Neonatal Asphyxiated Resuscitation Completed NCT01866358 Not Applicable
40 Does Placenta Pathology Predict Outcome of Neonates With Hypoxic Ischemic Encephalopathy?" Completed NCT03284528
41 Early or Late Cord Clamping in the Depressed Neonate Completed NCT02727517 Not Applicable
42 Saving Lives at Birth in Uganda: Building and Sustaining Capacity of Frontline Health Workers - A Program Evaluation Completed NCT03254628 Not Applicable oxytocin and misoprostol
43 Home Based Child Care to Reduce Mortality and Malnutrition in Tribal Children of Melghat, India: CRCT Completed NCT02473796 Not Applicable
44 Evaluating the Effects of SMS Text Messaging Support System Among Frontline Health Workers in Ghana Completed NCT02468310 Not Applicable
45 Infant Special Program for In Hospital Resuscitation Education in the Delivery Room Completed NCT02347241 Not Applicable
46 Introducing Fetal Scalp Stimulation as an Adjunct to Intermittent Auscultation in Low-Resource Settings. Completed NCT02862925 Not Applicable
47 A Skills and Drills Intervention for Emergency Obstetrics and Neonatal Care at First Referral Units of North Karnataka Completed NCT01865656 Not Applicable
48 TOBY (TOtal Body hYpothermia): a Study of Treatment for Perinatal Asphyxia Completed NCT00147030 Not Applicable
49 Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma in Healthy and Sick Children Completed NCT01044940
50 Post Term Pregnancy - Induction of Labor or Monitoring of Pregnancy Completed NCT00385229 Not Applicable induction of labor

Search NIH Clinical Center for Asphyxia Neonatorum

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Asphyxia Neonatorum cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Asphyxia Neonatorum:
Cord blood-derived hematopoietic stem cells for treatment of oxygen deprivation in newborns
Embryonic/Adult Cultured Cells Related to Asphyxia Neonatorum:
Umbilical cord blood-derived hematopoietic stem cells (family)

Cochrane evidence based reviews: asphyxia neonatorum

Genetic Tests for Asphyxia Neonatorum

Anatomical Context for Asphyxia Neonatorum

MalaCards organs/tissues related to Asphyxia Neonatorum:

41
Brain, Heart, Lung, Kidney, Liver, Placenta

Publications for Asphyxia Neonatorum

Articles related to Asphyxia Neonatorum:

(show top 50) (show all 85)
# Title Authors Year
1
Human recombinant erythropoietin in asphyxia neonatorum: pilot trial. ( 20385632 )
2010
2
Defending a neurologic birth injury. Asphyxia neonatorum redux. ( 19499449 )
2009
3
Is it time to revisit a role for antithrombotic therapy in asphyxia neonatorum? ( 15080111 )
2004
4
Renal insult in asphyxia neonatorum. ( 11042710 )
2000
5
Hepatic profile in asphyxia neonatorum. ( 9567557 )
1997
6
Maternal factors contributing to asphyxia neonatorum. ( 8816028 )
1996
7
Influence of maternal nutritional status on mode of delivery and asphyxia neonatorum. ( 1398866 )
1992
8
Myocardial changes in neonates dying of asphyxia neonatorum. ( 1344220 )
1992
9
Foetal co-relates and mode of delivery in asphyxia neonatorum. ( 1937632 )
1991
10
ECG changes in asphyxia neonatorum. ( 2081640 )
1990
11
Definition and grading of asphyxia neonatorum. ( 3775608 )
1986
12
Asphyxia neonatorum. ( 3711811 )
1986
13
Myocardial ischaemia in asphyxia neonatorum. Electrocardiographic, enzymatic and histological correlations. ( 4024929 )
1985
14
Asphyxia neonatorum: a clinical evaluation of 60 affected infants. ( 1193708 )
1975
15
Management of asphyxia neonatorum. ( 1193711 )
1975
16
Asphyxia neonatorum--assessment of the infant at birth. ( 4473836 )
1974
17
Asphyxia neonatorum--incidence in Cape Town. ( 4428302 )
1974
18
Letter: Asphyxia neonatorum. ( 4475487 )
1974
19
Neonatal complications and conditions associated with asphyxia neonatorum. ( 4432179 )
1974
20
Asphyxia neonatorum--neurological status at one year follow-up. ( 4473837 )
1974
21
Asphyxia neonatorum. ( 4799713 )
1973
22
Asphyxia neonatorum caused by foaming. ( 4112571 )
1972
23
Hyponatremia following asphyxia neonatorum. ( 5448486 )
1970
24
Asphyxia neonatorum. ( 5529468 )
1970
25
Memory deficit in monkeys brain damaged by asphyxia neonatorum. ( 4979089 )
1969
26
Asphyxia neonatorum. ( 5587613 )
1967
27
The use of hyperbaric oxygen in asphyxia neonatorum and the respiratory distress syndrome. ( 6003308 )
1966
28
Controlled trials of hyperbaric oxygen and tracheal intubation in asphyxia neonatorum. ( 4160515 )
1966
29
On the influence of abnormal parturition, difficult labours, premature birth, and asphyxia neonatorum, on the mental and physical condition of the child, especially in relation to deformities. ( 5950310 )
1966
30
TREATMENT OF ASPHYXIA NEONATORUM BY HYPERBARIC OXYGENATION. ( 14252020 )
1965
31
ASPHYXIA NEONATORUM. ( 14116230 )
1964
32
HYPOTHERMIA IN THE TREATMENT OF ASPHYXIA NEONATORUM. ( 14136494 )
1964
33
[CHOLINESTERASE ACTIVITY OF THE BLOOD SERUM IN FETAL DEATH, ASPHYXIA NEONATORUM AND FETAL DEFORMITIES]. ( 14256126 )
1964
34
ASPHYXIA NEONATORUM. ( 14044048 )
1963
35
Structural and functional sequelae of asphyxia neonatorum in monkeys (Macaca mulatta). ( 14007461 )
1962
36
Hypothermia and transfusion with oxygenated blood in the treatment of asphyxia neonatorum. ( 14000132 )
1962
37
Effects of asphyxia neonatorum on behavior in the Rhesus monkey. ( 14497712 )
1961
38
The weight of the heart of mature infants after asphyxia neonatorum. ( 13689151 )
1961
39
Maternal and obstetric factors in asphyxia neonatorum with a preliminary report on a possible association with ABO blood groups. ( 13683009 )
1960
40
Brain damage in the monkey, macaca mulatta, by asphyxia neonatorum. ( 13663899 )
1959
41
An electronic resuscitator for possible use in asphyxia neonatorum. ( 13616412 )
1958
42
Asphyxia neonatorum. ( 13479645 )
1957
43
Neurological and psychological deficits from asphyxia neonatorum. ( 13441865 )
1957
44
Management of asphyxia neonatorum. ( 13359430 )
1956
45
Asphyxia neonatorum. ( 13310418 )
1956
46
Causation and treatment of asphyxia neonatorum. ( 13306743 )
1956
47
An experimental study of the human fetus with special reference to asphyxia neonatorum. ( 13292259 )
1955
48
Late result of prolonged endotracheal insufflation in asphyxia neonatorum. ( 14389722 )
1955
49
Asphyxia neonatorum: its clinical features and treatment. ( 13292258 )
1955
50
Pathological anatomy of asphyxia neonatorum. ( 13292256 )
1955

Variations for Asphyxia Neonatorum

Expression for Asphyxia Neonatorum

Search GEO for disease gene expression data for Asphyxia Neonatorum.

Pathways for Asphyxia Neonatorum

GO Terms for Asphyxia Neonatorum

Cellular components related to Asphyxia Neonatorum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 I band GO:0031674 8.96 MTM1 TTN
2 ruffle GO:0001726 8.8 MTM1 MTMR14 S100B

Biological processes related to Asphyxia Neonatorum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of insulin secretion GO:0050796 8.96 ABCC8 SLC16A1
2 phosphatidylinositol biosynthetic process GO:0006661 8.8 MTM1 MTMR14 PIK3C2A

Molecular functions related to Asphyxia Neonatorum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-3-phosphatase activity GO:0004438 8.96 MTM1 MTMR14
2 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity GO:0052629 8.62 MTM1 MTMR14

Sources for Asphyxia Neonatorum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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