Aspiration Pneumonia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ASP007 MIFTS: 48	Aspiration Pneumonia Categories: Gastrointestinal diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Aspiration Pneumonia

MalaCards integrated aliases for Aspiration Pneumonia:

Name: Aspiration Pneumonia ¹² ⁷⁴ ²⁹ ⁶ ¹⁵ ⁷¹

Pneumonia, Aspiration ⁴³ ¹⁷

Aspiration Pneumonitis ⁷¹

Pneumonia Aspiration ⁵⁴

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases Gastrointestinal diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the respiratory system

Lung diseases due to external agents

Pneumonitis due to solids and liquids

Pneumonitis due to food and vomit

External Ids:

Disease Ontology ¹² DOID:0050152

MeSH ⁴³ D011015

SNOMED-CT ⁶⁷ 47839005

ICD10 ³² J69.0

EFO ¹⁷ EFO_1001399

UMLS ⁷¹ C0032290 C1761609

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Summaries for Aspiration Pneumonia

Disease Ontology : ¹² A bacterial pneumonia which is an acute pulmonary inflammatory response that develops after the inhalation of colonized oropharyngeal material containing bacteria. It is seen in individuals with dysphagia and gastric dysmotility. The disease has symptom tachypnea and has symptom cough.

MalaCards based summary : Aspiration Pneumonia, also known as pneumonia, aspiration, is related to eclampsia and aspiration pneumonitis. An important gene associated with Aspiration Pneumonia is CHAT (Choline O-Acetyltransferase), and among its related pathways/superpathways are Folate Metabolism and amb2 Integrin signaling. The drugs Magnesium oxide and Magnesium citrate have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and colon, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : ⁷⁴ Aspiration pneumonia is a type of lung infection that is due to a relatively large amount of material... more...

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Related Diseases for Aspiration Pneumonia

Diseases related to Aspiration Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 627)

#	Related Disease	Score	Top Affiliating Genes
1	eclampsia	32.5	F2 ALB ACE
2	aspiration pneumonitis	32.4	TEF SLC22A4 F3 CRP ATP4A ATP12A
3	lung abscess	30.9	LACTB IL6 CRP ALB
4	bronchiolitis	30.8	IL6 IL17A CRP
5	bronchopneumonia	30.8	IL6 CRP ALB
6	cerebrovascular disease	30.5	IL6 F2 CRP ACE
7	periodontitis, chronic	30.5	MMP8 IL6
8	pulmonary edema	30.4	PIK3C2A F2 CRP ACE
9	hernia, hiatus	30.4	TEF CRP ATP4A ATP12A
10	peptic ulcer disease	30.4	ATP4A ATP12A ALB
11	laryngeal disease	30.4	MMP8 ATP4A ATP12A
12	bacterial pneumonia	30.3	LACTB IL6 IL17A CRP ALB
13	constipation	30.3	TAC1 CHAT ATP4A ATP12A
14	periodontitis	30.3	MMP8 IL6 IL17A CRP
15	esophageal disease	30.3	TEF ATP4A ATP12A ALB
16	bronchitis	30.2	TAC1 LACTB IL6 CRP ALB
17	vasculitis	30.2	ITGAM IL6 IL17A CRP
18	peptic esophagitis	30.2	IL6 ATP4A ATP12A ALB
19	cranial nerve palsy	30.2	CRP ALB ACE
20	klebsiella pneumonia	30.2	LACTB IL17A CRP ALB
21	viral pneumonia	30.2	IL6 IL17A CRP
22	duodenal obstruction	30.1	TEF ATP4A ATP12A ALB
23	left bundle branch hemiblock	30.1	PIK3C2A CRP ACE
24	pneumonia	30.1	PIK3C2A MMP8 LACTB ITGAM IL6 IL17A
25	common cold	30.1	IL6 IL17A ALB
26	ileus	30.1	IL6 IL17A F2 CRP
27	gas gangrene	30.1	PIK3C2A IL6 CRP
28	bacterial infectious disease	30.0	ITGAM IL6 IL17A CRP
29	lipid pneumonia	30.0	NPC2 CRP
30	sleep disorder	30.0	IL6 CRP ACE
31	bronchiolitis obliterans	29.9	MMP8 IL6 IL17A CRP
32	gastroenteritis	29.9	LACTB IL6 CRP ALB
33	pulmonary tuberculosis	29.9	IL6 IL17A CRP ALB
34	uremia	29.9	ITGAM IL6 CRP ALB ACE
35	vascular dementia	29.9	IL6 CRP CHAT ACE
36	hepatic encephalopathy	29.9	IL6 F2 ALB
37	leptin deficiency or dysfunction	29.9	IL6 CRP ALB
38	pulmonary embolism	29.8	F3 F2 CRP ALB ACE
39	otitis media	29.8	LACTB IL6 IL17A CRP ALB
40	volvulus of midgut	29.8	F2 CRP ATP4A ATP12A ALB
41	intestinal obstruction	29.7	IL6 CRP ATP4A ATP12A ALB
42	intracranial embolism	29.7	F3 F2 CRP ACE
43	neuromuscular disease	29.7	PABPN1 IL6 IL17A CHAT ALB
44	adult respiratory distress syndrome	29.7	IL6 F2 ACE
45	portal hypertension	29.7	F3 F2 ALB ACE
46	stroke, ischemic	29.6	IL6 F3 F2 CRP ALB ACE
47	myocarditis	29.6	PIK3C2A IL6 IL17A ALB ACE
48	lung disease	29.6	MMP8 IL6 IL17A F3 CRP ALB
49	congestive heart failure	29.5	PIK3C2A IL6 CRP ALB ACE
50	toxic shock syndrome	29.5	IL6 F3 CRP

Graphical network of the top 20 diseases related to Aspiration Pneumonia:

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Symptoms & Phenotypes for Aspiration Pneumonia

MGI Mouse Phenotypes related to Aspiration Pneumonia:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.11	ACE ALB ATP12A ATP4A CHAT CRP
2	cardiovascular system	MP:0005385	10.1	ACE ALB CHAT CRP F2 F3
3	digestive/alimentary	MP:0005381	9.86	ALB ATP12A ATP4A CHAT F2 IL17A
4	immune system	MP:0005387	9.77	ACE ALB ATP4A CRP F2 F3
5	mortality/aging	MP:0010768	9.44	ACE ALB ATP4A CHAT F2 F3

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Drugs & Therapeutics for Aspiration Pneumonia

Drugs for Aspiration Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 201)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Magnesium oxide

Approved

Phase 4

1309-48-4

14792

Magnesium citrate

Approved

Phase 4

3344-18-1

Sodium citrate

Approved, Investigational

Phase 4

68-04-2

Amoxicillin

Approved, Vet_approved

Phase 4

26787-78-0

33613

Clavulanate

Approved, Vet_approved

Phase 4

58001-44-8

5280980

Fentanyl

Approved, Illicit, Investigational, Vet_approved

Phase 4

437-38-7

3345

Desflurane

Approved

Phase 4

57041-67-5

42113

Propofol

Approved, Investigational, Vet_approved

Phase 4

2078-54-8

4943

Ketamine

Approved, Vet_approved

Phase 4

6740-88-1

3821

Dexmedetomidine

Approved, Vet_approved

Phase 4

113775-47-6

68602 5311068

Rocuronium

Approved

Phase 4

119302-91-9, 143558-00-3

441290

Succinylcholine

Approved

Phase 4

306-40-1

5314

Neostigmine

Approved, Vet_approved

Phase 4

59-99-4

4456

Remifentanil

Approved

Phase 4

132875-61-7

60815

Poractant alfa

Approved

Phase 4

129069-19-8

Lisinopril

Approved, Investigational

Phase 4

83915-83-7, 76547-98-3

5362119

Citric acid

Approved, Nutraceutical, Vet_approved

Phase 4

77-92-9

311

Calcium

Approved, Nutraceutical

Phase 4

7440-70-2

271

Ramosetron

Investigational

Phase 4

132036-88-5

Gastrointestinal Agents

Phase 4

Cathartics

Phase 4

Laxatives

Phase 4

Chelating Agents

Phase 4

Citrate

Phase 4

Anticoagulants

Phase 4

Anti-Ulcer Agents

Phase 4

Picosulfate sodium

Phase 4

Calcium, Dietary

Phase 4

Antacids

Phase 4

Antiemetics

Phase 4

Anti-Infective Agents

Phase 4

beta-Lactamase Inhibitors

Phase 4

Antitubercular Agents

Phase 4

Chlorhexidine gluconate

Phase 4

Disinfectants

Phase 4

Anti-Infective Agents, Local

Phase 4

Amoxicillin-Potassium Clavulanate Combination

Phase 4

Anti-Bacterial Agents

Phase 4

Antibiotics, Antitubercular

Phase 4

Adrenergic Agonists

Phase 4

Adrenergic alpha-2 Receptor Agonists

Phase 4

Vasoconstrictor Agents

Phase 4

Anesthetics, Dissociative

Phase 4

Analgesics, Non-Narcotic

Phase 4

Neuromuscular Agents

Phase 4

Neuromuscular Blocking Agents

Phase 4

Anesthetics, General

Phase 4

Anesthetics, Intravenous

Phase 4

Hypnotics and Sedatives

Phase 4

Neuromuscular Nondepolarizing Agents

Phase 4

Interventional clinical trials:

(show top 50) (show all 169)

#	Name	Status	NCT ID	Phase	Drugs
1	Phase IV, Prospective, Randomized Study Comparing Preparation the Day Before and Split-dose Regimen With Sodium Picosulphate/Magnesium Citrate for Morning Colonoscopies	Unknown status	NCT01481714	Phase 4	Sodium picosulphate, magnesium oxid and citric acid;Sodium picosulphate/magnesium oxide and citric acid
2	Effect of Oral Decontamination Using Chlorhexidine or Potassium Permanganate in ICU Patients: an Open-Labelled Randomized Controlled Trial	Completed	NCT00610324	Phase 4	Chlorhexidine gluconate;Potassium permanganate
3	The Effect of Total Intravenous Anesthesia With Propofol on Postoperative Nausea and Vomiting in Patients Undergoing Robot-assisted Laparoscopic Radical Prostatectomy	Completed	NCT01402622	Phase 4	Propofol anesthesia
4	Laryngoscope Versus CMAC for Endotracheal Intubation in Patients Undergoing Emergent Airway Management	Completed	NCT01710891	Phase 4
5	Pneumonia in Children: Aetiology, Ideal Antibiotic Duration, Quality of Life	Completed	NCT02258763	Phase 4	Amoxicillin-Potassium Clavulanate Combination;Placebo
6	PROcalcitonin Pneumonia / Pneumonitis Associated With ASPIration	Recruiting	NCT02862314	Phase 4
7	Eliminating Use of Non Depolarizing Neuromuscular Blocking Agents to Reduce Postoperative Pulmonary Complications: A Multi-center, Randomized Control Trial	Recruiting	NCT03962725	Phase 4	Neuromuscular Blocking Agents;Anesthetic Adjuncts
8	The Effect of Sugammadex Versus Neostigmine on Postoperative Pulmonary Complications in Patients 70 Years or Older and Scheduled for 3 Hour or Longer Surgery-A Randomized Controlled Trial	Active, not recruiting	NCT02861131	Phase 4	Sugammadex;Neostigmine
9	Stress Assessment in Preterm Infants With Respiratory Distress Syndrome Treated or Not With an Analgesic Drug During the Traditional or the Less Invasive Method of Surfactant Therapy.	Not yet recruiting	NCT04073173	Phase 4	Analgesic, Opioid
10	A Randomized Placebo Controlled Trial of Low Dose Angiotensin Converting Enzyme Inhibitor to Prevent Pneumonia in Older People Who Require Tube Feeding Because of Neurological Dysphagia	Terminated	NCT02358642	Phase 4	Angiotensin converting enzyme inhibitor (Lisinopril);Placebo
11	Efficacy and Cost Efficacy of Prophylactic Treatment With Antibiotics During Concomitant Chemoradiotherapy in Patients With Locally Advanced Head and Neck Cancer to Prevent Aspiration Pneumonia. A Randomized Phase II-III Study	Unknown status	NCT01598402	Phase 2, Phase 3	amoxicillin/clavulanic acid suspension
12	Phase 2/3 Application of Botulinum Neurotoxin Type A in Salivary Glands as a Treatment of Chronic Drooling in Patients With Cerebral Palsy: A Controlled Clinical Trial.	Unknown status	NCT01489904	Phase 2, Phase 3
13	Prospective, Multi-center, Randomized, Non-blind Trial to Assess the Efficacy and Safety of Moxifloxacin Versus Sulbactam/Ampicillin in the Treatment of Pulmonary Abscess and Aspiration Pneumonia	Completed	NCT01045902	Phase 3	Avelox (Moxifloxacin, BAY12-8039);Sulbactam/Ampicillin
14	Venticute in Patients With Pneumonia or Aspiration of Gastric Contents Leading to Intubation, Ventilation, and Severe Oxygenation Impairment: A Randomized, Multinational, Multicenter, Parallel Group, Double Blind, Control Group Study	Completed	NCT00074906	Phase 3	Venticute
15	Sellick Maneuver Evaluation in Rapid Sequence Induction of General Anesthesia Non Inferiority Trial	Completed	NCT02080754	Phase 3
16	A Randomised Controlled Trial of Dysphagia Therapies for Swallowing Disorders Following Stroke.	Completed	NCT00257764	Phase 2, Phase 3
17	The Effects of Bronchodilator Therapy On Respiratory and Autonomic Function in Patients With Familial Dysautonomia	Completed	NCT01987219	Phase 3	Albuterol-sulphate;Ipratropium-bromide
18	Muscle Preservation and Swallow Function Following Radiotherapy: A Dose Response Study	Completed	NCT01279837	Phase 2, Phase 3
19	Esophageal Stent is More Effective Than Tamponade Controlling Refractory Esophageal Variceal Bleeding: a Randomized Controlled Trial	Completed	NCT01242280	Phase 3
20	Survey of Miglustat Therapeutic Effects on Neurological and Systemic Symptoms of Infantile Type of Sandhoff and Taysachs Diseases	Recruiting	NCT03822013	Phase 3	Miglustat
21	Randomized Study of Two Interventions for Liquid Aspiration: Short-Term and Long-Term Effects	Terminated	NCT00000362	Phase 3
22	Calfactant Therapy for Direct Acute Respiratory Distress Syndrome & Direct Acute Lung Injury in Adults and Children	Terminated	NCT00682500	Phase 3	Calfactant;Room Air (placebo)
23	The Randomized Inhaled Nitric Oxide Study (NINOS) in Full-Term and Nearly Full-Term Infants With Hypoxic Respiratory Failure	Terminated	NCT00005776	Phase 3	Inhaled nitric oxide;Placebo
24	Early Inhaled Nitric Oxide Therapy in Term and Near Term Infants With Respiratory Failure	Terminated	NCT00005773	Phase 3	Inhaled Nitric Oxide;Standard iNO therapy
25	Inhaled Nitric Oxide for Preterm Infants With Severe Respiratory Failure	Terminated	NCT00016523	Phase 3	Inhaled nitric oxide;Placebo
26	Evaluation of Transcutaneous Electrical Stimulation in Post Stroke Dysphagia	Terminated	NCT01971320	Phase 3
27	Regular Versus Liquid Diet as the First Meal in Patients Undergoing Major Abdominal Gynecologic Cancer Operation: A Randomized Controlled Trial	Withdrawn	NCT00328757	Phase 3
28	Effect of Daikenchuto (TJ-100) on Intestinal Dysmotility and For the Prevention of Postoperative Paralytic Ileus in Patients Undergoing Pancreaticoduodenectomy: A Multicenter, Randomized, Placebo-Controlled Phase II Trial	Unknown status	NCT01607307	Phase 2	Oral/enteral TJ-100 solution;Oral/enteral placebo solution
29	Low-dose Intra-arterial Bevacizumab for Edema and Radiation Necrosis Therapeutic Intervention (LIBERTI)	Unknown status	NCT02819479	Phase 2	25% Mannitol;Low-dose Intra-arterial Bevacizumab
30	Effect of Oral Menthol on the Swallow Response of Patients With Oropharyngeal Dysphagia Associated With Neurological Diseases and Aging	Completed	NCT03050957	Phase 2
31	A Pilot Therapeutic Trial Using Hydroxyurea in Type I Spinal Muscular Atrophy Patients	Completed	NCT00568698	Phase 1, Phase 2	Hydroxyurea;Placebo to match hydroxyurea
32	Effectiveness of a New Neuromuscular Electrical Stimulation (NMES) Treatment Technique (VitalStim® Therapy) in the Management of Young Infants With Severe Dysphagia: a Prospective Pilot Study	Completed	NCT01723358	Phase 2
33	Identifying and Treating Arousal Related Deficits in Neglect and Dysphagia	Completed	NCT01085903	Phase 2	Modafinil;Placebo
34	Effect of Afferent Oropharyngeal Pharmacological and Electrical Stimulation on Swallow Response and on Activation of Human Cortex in Stroke Patients With Oropharyngeal Dysphagia (OD). A Randomized Controlled Trial.	Completed	NCT01777672	Phase 2
35	Establishing Normal Swallowing and Breathing Profiles in Healthy Adults Across the Age Span	Completed	NCT03122145	Phase 1, Phase 2	Capsaicin
36	Aromatherapy for Postoperative Nausea and Vomiting in Children: A Single Blind Randomized Clinical Trial	Completed	NCT02663154	Phase 2	Aromatherapy inhaler;Saline inhaler
37	Induction of Volitional Swallowing in Chronic Dysphagia Post Stroke: A Novel Mechanism-Based Intervention	Completed	NCT00306501	Phase 2
38	Treatment of Dysphagia in Oculopharyngeal Muscular Dystrophy by Autologous Transplantation of Myoblasts	Completed	NCT00773227	Phase 2
39	Cough and Swallow Rehabilitation Following Stroke	Completed	NCT01907321	Phase 1, Phase 2	Measures performed on all subjects
40	Novel Management of Airway Protection in Parkinson's Disease: A Clinical Trial	Recruiting	NCT02927691	Phase 2
41	The Nutritional Supplement Phosphatidylserine in Patients With Familial	Recruiting	NCT02276716	Phase 2	Phosphatidylserine
42	Therapeutic Impact of tDCS on Dysphagia in the Acute Phase of Stroke / Impact thérapeutique de la tDCS Sur la Dysphagie en Phase Aigue de l'Accident Vasculaire cérébral	Active, not recruiting	NCT01758991	Phase 1, Phase 2
43	Effect Of Early Initiation Of Noninvasive Positive Pressure Ventilation On ICU Length Of Stay In Children With Status Asthmaticus, A Prospective Randomized Trial	Withdrawn	NCT01403428	Phase 2
44	A Randomised Placebo Controlled Trial to Explore the Effectiveness of Botulinum Toxin Injection at Reducing Oral Secretions and Frequency of Tracheal Suctioning in Tracheotomised Patients.	Withdrawn	NCT00973999	Phase 2	Botulinum Toxin
45	Comparison of GERD and the Effects of Anti-Reflux Therapy on Pulmonary Function Between Able-Bodied and SCI Individuals	Unknown status	NCT02584751	Phase 1	Omeprazole
46	Airway Protection Deficits According to Stimulus Type in Parkinson's Disease	Completed	NCT02390089	Phase 1	Capsaicin vapor
47	PentoxIfylline and Tocopherol for the Treatment of Post-radiotherapy Fibrosis in Head and Neck Cancer Patients: a Feasibility Study	Not yet recruiting	NCT03723291	Phase 1
48	Dynamic Laryngotracheal Separation for Aspiration. Prevention of Silent Aspiration Pneumonia During Swallowing by an Implanted Stimulator	Suspended	NCT00580346	Phase 1
49	Validation of a Marker for Aspiration and Endotracheal Tube Cuff Leak.	Withdrawn	NCT02301845	Phase 1	Diatoms Shells
50	Salivary Alpha Amylase Bronchial Measure for Early Aspiration Pneumonia Diagnosis in Patients Treated With Therapeutic Hypothermia After Out-of-hospital Cardiac Arrest.	Unknown status	NCT03007862

Search NIH Clinical Center for Aspiration Pneumonia

Cochrane evidence based reviews: pneumonia, aspiration

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Genetic Tests for Aspiration Pneumonia

Genetic tests related to Aspiration Pneumonia:

#	Genetic test	Affiliating Genes
1	Aspiration Pneumonia ²⁹

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Anatomical Context for Aspiration Pneumonia

MalaCards organs/tissues related to Aspiration Pneumonia:

⁴⁰

Lung, Brain, Colon, Testes, Heart, Tongue, Liver

Sources

Publications for Aspiration Pneumonia

Articles related to Aspiration Pneumonia:

(show top 50) (show all 3997)

#	Title	Authors	PMID	Year
1	Aspiration pneumonia and primary lung abscess: diagnosis and therapy of an aerobic or an anaerobic infection? ⁵⁴ ⁶¹	Allewelt M	20477271	2007
2	Laryngeal Disease in Dogs and Cats: An Update. ⁶¹	MacPhail CM	31882166	2020
3	Echocardiography-Guided Dual-Lumen Venovenous Extracorporeal Membrane Oxygenation Cannula Placement in the ICU-A Retrospective Review. ⁶¹	Griffee MJ...Tonna JE	31812567	2020
4	Individualized prediction of late-onset dysphagia in head and neck cancer survivors. ⁶¹	Aylward A...Monroe MM	32031294	2020
5	A case of esophageal cancer with human immunodeficiency virus infection that progressed rapidly after neoadjuvant chemoradiotherapy. ⁶¹	Hayakawa Y...Fujiki K	31352645	2020
6	Diffuse leiomyomatosis with circumferential thickening of the gastrointestinal wall, resembling human diffuse leiomyomatosis, in a young miniature dachshund. ⁶¹	Kuramochi M...Yamate J	31852861	2020
7	Unusual trifecta of infections, aspiration, and metastatic prostatic adenocarcinoma in a bronchoalveolar lavage specimen. ⁶¹	Wang BG...Khan J	31639284	2020
8	Dysphagia Screening for Pneumonia Prevention in a Cancer Hospital: Results of a Quality/Safety Initiative. ⁶¹	Ebersole B...Jamal N	31791195	2020
9	Cefepime vs. meropenem for moderate-to-severe pneumonia in patients at risk for aspiration: An open-label, randomized study. ⁶¹	Oi I...Hirai T	31473111	2020
10	Association between dipeptidyl peptidase-4 inhibitor and aspiration pneumonia: disproportionality analysis using the spontaneous reporting system in Japan. ⁶¹	Noguchi Y...Teramachi H	31822955	2020
11	Superior Laryngeal Nerve Palsy in Revision Anterior Cervical Surgery. ⁶¹	Konopka JA...Rhee JM	31246644	2020
12	Protecting Patient Safety and Preventing Modifiable Complications After Acute Ischemic Stroke. ⁶¹	Tamburri LM...Orzano D	32006035	2020
13	Aural stimulation with capsaicin prevented pneumonia in dementia patients. ⁶¹	Jinnouchi O...Takeda N	31280931	2020
14	A cost effective custom dental guard for transoral robotic surgery. ⁶¹	Benito D...Joshi AS	30826917	2020
15	Motor Learning Feeding Interventions for Infants at Risk of Cerebral Palsy: A Systematic Review. ⁶¹	Khamis A...Badawi N	31069491	2020
16	Oropharyngeal dysphagia among patients newly discharged to nursing home care after an episode of hospital care. ⁶¹	Horgan E...O'Neill D	31332709	2020
17	Pre-implantation genetic diagnosis in an Iranian family with a novel mutation in MUT gene. ⁶¹	Habibzadeh P...Faghihi MA	32013889	2020
18	Per-oral endoscopic myotomy for esophageal diverticula with or without esophageal motility disorders. ⁶¹	Orlandini B...Chaussade S	31080116	2020
19	Brachycephalic airway syndrome: management of post-operative respiratory complications in 248 dogs. ⁶¹	Lindsay B...Moses P	32037517	2020
20	Cemiplimab in locally advanced cutaneous squamous cell carcinoma: results from an open-label, phase 2, single-arm trial. ⁶¹	Migden MR...Rischin D	31952975	2020
21	[Pulmonary complications in cocaine users]. ⁶¹	Underner M...Jaafari N	31883817	2020
22	[A case of systemic AL amyloidosis diagnosed on muscle biopsy]. ⁶¹	Yata T...Tatsumi C	31852873	2020
23	Outcomes of enteral metallic stent in patients with pancreatic carcinoma and gastric outlet obstruction: A single center experience. ⁶¹	Chang KB...Lee KC	31171401	2020
24	Giant axonal neuropathy: a multicenter retrospective study with genotypic spectrum expansion. ⁶¹	Echaniz-Laguna A...Latour P	31655922	2020
25	Spectrum of 18F-FDG Uptake in Bilateral Lung Parenchymal Diseases on PET/CT. ⁶¹	Prabhu M...Kumar R	31524673	2020
26	Megaesophagus Is a Major Pathological Condition in Rats With a Large Deletion in the Rbm20 Gene. ⁶¹	Schwahn DJ...Greaser ML	31221019	2020
27	Multiple cause of death analysis in multiple sclerosis: A population-based study. ⁶¹	Harding K...Kingwell E	31932517	2020
28	Percutaneous endoscopic gastrostomy with jejunal extension for a post-esophagectomy gastric conduit. ⁶¹	Urabe M...Udagawa H	31981087	2020
29	Management of dysphagia in Huntington's disease: a descriptive review. ⁶¹	Pizzorni N...Schindler A	31989345	2020
30	Total Oesophagogastric Dissociation in Neurologically Impaired Children: 18 Years' Experience and Long-Term Follow-Up. ⁶¹	Battaglia S...Alberti D	31913925	2020
31	Aspiration pneumonia after antireflux surgery among neurologically impaired children with GERD. ⁶¹	Maret-Ouda J...Lagergren J	32037217	2020
32	Incomplete recovery from rocuronium-induced muscle relaxation in patients with amyotrophic lateral sclerosis using sugammadex: A case report. ⁶¹	Chun HR...Kang KS	32011508	2020
33	Management of Dysphagia in Patients with Parkinson's Disease and Related Disorders. ⁶¹	Umemoto G...Furuya H	30996170	2020
34	Thrombocytopenia associated with clonidine in a case of clozapine-induced sialorrhea. ⁶¹	Leung JG...Schak KM	31942277	2020
35	Psychiatric inpatients subjected to physical restraint have a higher risk of deep vein thrombosis and aspiration pneumonia. ⁶¹	Funayama M...Takata T	31734627	2020
36	Food bolus-forming ability predicts incidence of aspiration pneumonia in nursing home older adults: A prospective observational study. ⁶¹	Hase T...Sugama J	31299094	2020
37	Association between sarcopenia and pneumonia in older people. ⁶¹	Okazaki T...Ebihara T	31808265	2020
38	Spatiotemporal clustering of in-hospital Clostridioides difficile infection. ⁶¹	Pai S...CDC MInD-Healthcare group	32000873	2020
39	Endoscopic Nasoenteral Feeding Tube Fixation with Hemoclip Reduces Tube Dislodgement. ⁶¹	Han J...Jung HY	31367879	2020
40	The Mini Nutritional Assessment-Short Form as a predictor of nursing home mortality in Japan: A 30-month longitudinal study. ⁶¹	Motokawa K...Watanabe Y	31710866	2020
41	Clinical characteristics of exposures to liquid laundry detergent packets. ⁶¹	Banner W...Green JL	31578092	2020
42	A Comparative Study of Two Tube Feeding Methods in Patients with Dysphagia After Stroke: A Randomized Controlled Trial. ⁶¹	Juan W...Jian-Tian H	31924485	2020
43	Pulmonary Complications of Opioid Overdose Treated With Naloxone. ⁶¹	Farkas A...Martin-Gill C	31182316	2020
44	Amoxicillin-Clavulanate Dosing in the Intensive Care Unit: The Additive Effect of Renal Replacement Therapy in a Patient with Normal Kidney Function. ⁶¹	Lonsdale DO...Roberts JA	31940615	2020
45	Endoscopic retrieval of gastric and oesophageal foreign bodies in 52 cats. ⁶¹	Dollo V...Carothers M	31709553	2020
46	Rapid versus slow withdrawal of antiepileptic drugs. ⁶¹	Ayuga Loro F...Brigo F	31990368	2020
47	Long-Term Safety and Efficacy of Blonanserin Transdermal Patches in Japanese Patients with Schizophrenia: A 52-Week Open-Label, Multicenter Study. ⁶¹	Iwata N...Higuchi T	31883082	2020
48	Riluzole-induced interstitial lung disease is a rare and potentially life-threatening adverse event successfully treated with high-dose steroid therapy: Case reports and review of the literature. ⁶¹	Saitoh Y...Takahashi Y	31901592	2019
49	Gastroesophageal reflux and respiratory diseases: does a real link exist? ⁶¹	Bongiovanni A...Leonardi S	31129955	2019
50	Esophageal Dysphagia in the Elderly. ⁶¹	Chan MQ...Balasubramanian G	31741211	2019

Sources

Genes for Aspiration Pneumonia

Genes related to Aspiration Pneumonia (1 elite genes):

(show all 26)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CHAT	Choline O-Acetyltransferase	Protein Coding	411.46	Pathogenic ⁶ DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
2	LACTB	Lactamase Beta	Protein Coding	12.34	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	20477271
3	IL17A	Interleukin 17A	Protein Coding	11.32	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	ITGAM	Integrin Subunit Alpha M	Protein Coding	10.4	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	MYH2	Myosin Heavy Chain 2	Protein Coding	10.11	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	ATP4A	ATPase H+/K+ Transporting Subunit Alpha	Protein Coding	7.23	DISEASES inferred ¹⁵
7	ATP12A	ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit	Protein Coding	7.22	DISEASES inferred ¹⁵
8	TEF	TEF Transcription Factor, PAR BZIP Family Member	Protein Coding	7.09	DISEASES inferred ¹⁵
9	CRP	C-Reactive Protein	Protein Coding	6.96	DISEASES inferred ¹⁵
10	ALB	Albumin	Protein Coding	6.81	DISEASES inferred ¹⁵
11	MMP8	Matrix Metallopeptidase 8	Protein Coding	6.4	DISEASES inferred ¹⁵
12	TAC1	Tachykinin Precursor 1	Protein Coding	6.1	DISEASES inferred ¹⁵
13	PABPN1	Poly(A) Binding Protein Nuclear 1	Protein Coding	5.96	DISEASES inferred ¹⁵
14	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	5.9	DISEASES inferred ¹⁵
15	ACE	Angiotensin I Converting Enzyme	Protein Coding	5.87	DISEASES inferred ¹⁵
16	SLC22A4	Solute Carrier Family 22 Member 4	Protein Coding	5.79	DISEASES inferred ¹⁵
17	F2	Coagulation Factor II, Thrombin	Protein Coding	5.77	DISEASES inferred ¹⁵
18	IL6	Interleukin 6	Protein Coding	5.72	DISEASES inferred ¹⁵
19	F3	Coagulation Factor III, Tissue Factor	Protein Coding	5.6	DISEASES inferred ¹⁵
20	NPC2	NPC Intracellular Cholesterol Transporter 2	Protein Coding	5.47	DISEASES inferred ¹⁵
21	NPC1	NPC Intracellular Cholesterol Transporter 1	Protein Coding	5.47	DISEASES inferred ¹⁵
22	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	5.44	DISEASES inferred ¹⁵
23	TRPV1	Transient Receptor Potential Cation Channel Subfamily V Member 1	Protein Coding	5.38	DISEASES inferred ¹⁵
24	CD40LG	CD40 Ligand	Protein Coding	5.38	DISEASES inferred ¹⁵
25	INS	Insulin	Protein Coding	5.36	DISEASES inferred ¹⁵
26	HECTD4	HECT Domain E3 Ubiquitin Protein Ligase 4	Protein Coding	5.32	DISEASES inferred ¹⁵

Sources

Variations for Aspiration Pneumonia

ClinVar genetic disease variations for Aspiration Pneumonia:

⁶ ‎‎ ‎‎

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	CHAT	NM_020549.4(CHAT):c.2081C>G (p.Ser694Cys)	SNV	Pathogenic	523529	rs201439531	10:50872926-50872926	10:49664880-49664880
2	CHAT	NM_020549.4(CHAT):c.1061C>T (p.Thr354Met)	SNV	Conflicting interpretations of pathogenicity	523528	rs769234940	10:50835781-50835781	10:49627735-49627735

Sources

Expression for Aspiration Pneumonia

Search GEO for disease gene expression data for Aspiration Pneumonia.

Sources

Pathways for Aspiration Pneumonia

Pathways related to Aspiration Pneumonia according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	11.59	IL6 F2 CRP ALB
2	amb2 Integrin signaling ¹	10.48	MYH2 ITGAM IL6

Sources

GO Terms for Aspiration Pneumonia

Cellular components related to Aspiration Pneumonia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.65	TAC1 NPC2 MMP8 IL6 IL17A F3
2	extracellular space	GO:0005615	9.4	TAC1 NPC2 MMP8 ITGAM IL6 IL17A

Biological processes related to Aspiration Pneumonia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of neuroinflammatory response	GO:0150078	9.37	MMP8 IL6
2	regulation of neuroinflammatory response	GO:0150077	9.32	MMP8 IL6
3	negative regulation of lipid storage	GO:0010888	9.26	IL6 CRP
4	neutrophil mediated immunity	GO:0002446	9.16	IL6 ACE
5	regulation of microglial cell activation	GO:1903978	8.96	MMP8 IL6
6	acute-phase response	GO:0006953	8.8	IL6 F2 CRP

Molecular functions related to Aspiration Pneumonia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	sodium:potassium-exchanging ATPase activity	GO:0005391	9.16	ATP4A ATP12A
2	potassium-transporting ATPase activity	GO:0008556	8.96	ATP4A ATP12A
3	potassium:proton exchanging ATPase activity	GO:0008900	8.62	ATP4A ATP12A

Sources

Sources for Aspiration Pneumonia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia