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MCID: ASP007
MIFTS: 52

Aspiration Pneumonia

Categories: Gastrointestinal diseases, Infectious diseases, Respiratory diseases
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Aliases & Classifications for Aspiration Pneumonia

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MalaCards integrated aliases for Aspiration Pneumonia:

Name: Aspiration Pneumonia 11 75 28 5 14 71
Pneumonia, Aspiration 43 16
Aspiration Pneumonitis 71
Pneumonia Aspiration 53

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Respiratory diseases Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 31


External Ids:

Disease Ontology 11 DOID:0050152
MeSH 43 D011015
SNOMED-CT 68 47839005
ICD10 31 J69.0
UMLS 71 C0032290 C1761609
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Summaries for Aspiration Pneumonia

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Disease Ontology: 11 A bacterial pneumonia which is an acute pulmonary inflammatory response that develops after the inhalation of colonized oropharyngeal material containing bacteria. It is seen in individuals with dysphagia and gastric dysmotility. The disease has symptom tachypnea and has symptom cough.

MalaCards based summary: Aspiration Pneumonia, also known as pneumonia, aspiration, is related to megaesophagus and aspiration pneumonitis, and has symptoms including cough and tachypnea. An important gene associated with Aspiration Pneumonia is CHAT (Choline O-Acetyltransferase), and among its related pathways/superpathways are Sudden infant death syndrome (SIDS) susceptibility pathways and Dendritic Cells Developmental Lineage Pathway. The drugs Dopamine and Metoclopramide have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and tongue, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia: 75 Aspiration pneumonia is a type of lung infection that is due to a relatively large amount of material... more...
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Related Diseases for Aspiration Pneumonia

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Diseases related to Aspiration Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1124)
# Related Disease Score Top Affiliating Genes
1 megaesophagus 32.2 TNF ATP4A ATP12A
2 aspiration pneumonitis 31.8 TNF SERPINA3 IL6 F3 CRP ATP4A
3 eclampsia 31.7 TNF IL6 F3 F2 ALB ACE
4 pneumonia 31.3 TNF PIK3C2A LACTB IL6 GPT CRP
5 gastroesophageal reflux 31.0 TNF IL6 CHAT ATP4A ATP12A
6 haemophilus influenzae 30.8 TNF LACTB
7 achalasia 30.8 TNF CHAT ATP4A ATP12A
8 adult respiratory distress syndrome 30.7 TNF SERPINA3 IL6 CRP ACE2
9 nutritional deficiency disease 30.7 SERPINA3 IL6 F2 CRP ATP4A ATP12A
10 bronchiolitis 30.7 TNF IL6 CRP
11 lung abscess 30.6 TNF LACTB IL6 GPT CRP CD4
12 pulmonary edema 30.5 TNF PIK3C2A F2 CRP ACE
13 cerebrovascular disease 30.5 TNF SERPINA3 INS IL6 F2 CRP
14 pleural empyema 30.5 IL6 GPT F2 CRP CD4 ALB
15 bronchitis 30.5 TNF TAC1 LACTB IL6 CRP ALB
16 ileus 30.5 TNF IL6 CRP
17 bronchiectasis 30.4 TNF SERPINA3 IL6 CRP ALB
18 hernia, hiatus 30.4 INS CRP ATP4A ATP12A ALB
19 periodontitis 30.4 TNF SERPINA3 IL6 CRP
20 inappropriate adh syndrome 30.4 IL6 CRP ALB ACE
21 toxic shock syndrome 30.3 TNF IL6 F3 CRP
22 peptic esophagitis 30.3 TNF IL6 ATP4A ATP12A ALB
23 dental caries 30.3 IL6 CRP ALB ACE
24 cerebral palsy 30.2 TNF IL6 F2 CRP ALB
25 dementia 30.2 TNF SNCA SERPINA3 IL6 CHAT ACE
26 newborn respiratory distress syndrome 30.2 INS CRP ALB
27 meconium aspiration syndrome 30.2 TNF IL6 CRP ACE2
28 pulmonary embolism 30.1 F3 F2 CRP ALB ACE2 ACE
29 pulmonary tuberculosis 30.1 TNF IL6 CRP ALB
30 bronchiolitis obliterans 30.1 TNF IL6 CRP
31 vasculitis 30.1 TNF SERPINA3 IL6 CRP
32 interstitial lung disease 30.1 TNF SERPINA3 IL6 CRP
33 multiple system atrophy 1 30.1 SNCA SERPINA3 CHAT
34 bronchopneumonia 30.1 TNF SERPINA3 IL6 GPT CRP CD4
35 duodenal obstruction 30.0 GPT CRP ATP4A ATP12A ALB
36 duodenal ulcer 30.0 TNF INS IL6
37 alcohol dependence 30.0 TNF SNCA SERPINA3 INS GPT ALB
38 leptin deficiency or dysfunction 30.0 TNF INS IL6 CRP CD4
39 metabolic acidosis 30.0 IL6 GPT F2 ALB
40 uremia 30.0 TNF INS IL6 CRP ALB ACE
41 klebsiella pneumonia 30.0 LACTB GPT F3 CRP ALB
42 gastroenteritis 30.0 TNF LACTB IL6 CRP ALB
43 cranial nerve palsy 29.9 TNF F2 CRP CD4 ALB ACE
44 alzheimer disease, familial, 1 29.9 TNF SNCA SERPINA3 INS IL6 CHAT
45 stroke, ischemic 29.9 TNF SERPINA3 INS IL6 F3 F2
46 hepatic encephalopathy 29.9 TNF IL6 GPT F2 ALB
47 portal hypertension 29.9 TNF GPT F2 ALB ACE
48 demyelinating polyneuropathy 29.9 TNF IL6 CRP CD4 ALB
49 acute pancreatitis 29.9 TNF INS IL6 GPT CRP
50 severe acute respiratory syndrome 29.8 TNF IL6 GPT F3 CRP ACE2

Graphical network of the top 20 diseases related to Aspiration Pneumonia:



Diseases related to Aspiration Pneumonia
Sources

Symptoms & Phenotypes for Aspiration Pneumonia

About this section

Symptoms:

11
  • • cough
  • • tachypnea

GenomeRNAi Phenotypes related to Aspiration Pneumonia according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.18 ACE ACE2 ALB ATP12A ATP4A CD4
2 no effect GR00402-S-2 10.18 ACE ALB ATP12A ATP4A CD4 CHAT

MGI Mouse Phenotypes related to Aspiration Pneumonia:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.41 ACE ACE2 ALB ATP12A ATP4A CD4
2 growth/size/body region MP:0005378 10.31 ACE ACE2 ATP12A ATP4A CD4 CHAT
3 cardiovascular system MP:0005385 10.2 ACE ACE2 ALB CHAT CRP F2
4 renal/urinary system MP:0005367 10.19 ACE ACE2 ALB ATP12A IL6 INS
5 digestive/alimentary MP:0005381 10.15 ACE2 ALB ATP12A ATP4A CD4 CHAT
6 muscle MP:0005369 10.13 ACE2 ALB CHAT F2 F3 IL6
7 immune system MP:0005387 10.13 ACE ACE2 ALB ATP4A CD4 CRP
8 endocrine/exocrine gland MP:0005379 10.1 ACE ALB ATP4A CD4 F2 IL6
9 neoplasm MP:0002006 10.05 ACE ALB ATP4A F3 IL6 TCF21
10 hematopoietic system MP:0005397 9.97 ACE ACE2 ATP4A CD4 F2 F3
11 mortality/aging MP:0010768 9.8 ACE ACE2 ALB ATP4A CD4 CHAT
12 integument MP:0010771 9.36 ACE2 CD4 F2 F3 IL6 INS
Sources

Drugs & Therapeutics for Aspiration Pneumonia

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Drugs for Aspiration Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 86)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
2
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
3
Chlorhexidine Approved, Vet_approved, Withdrawn Phase 4 55-56-1 2713 9552079
4
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
5
Vancomycin Approved Phase 4 1404-90-6 14969
6
Ceftriaxone Approved Phase 4 73384-59-5 5479530
7
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
8
Cefepime Approved, Investigational Phase 4 88040-23-7 5479537
9
Meticillin Approved, Investigational Phase 4 61-32-5 6087
10
Ofloxacin Approved Phase 4 82419-36-1 4583
11
Clavulanic acid Approved, Vet_approved Phase 4 58001-44-8 5280980
12
Famotidine Approved Phase 4 76824-35-6 3325 5702160
13
Prucalopride Approved Phase 4 179474-81-8 3052762
14
Histamine Approved, Investigational Phase 4 51-45-6 774
15
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
16
Dexmedetomidine Approved, Experimental, Vet_approved Phase 4 86347-14-0, 113775-47-6 68602 5311068
17
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456 5824
18
Ketamine Approved, Vet_approved Phase 4 6740-88-1, 1867-66-9 3821
19
Remifentanil Approved Phase 4 132875-61-7 60815
20
Succinylcholine Approved Phase 4 306-40-1, 71-27-2 5314
21
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
22 Dopamine Antagonists Phase 4
23 Dopamine Agents Phase 4
24 Antiemetics Phase 4
25 Chlorhexidine gluconate Phase 4
26 Disinfectants Phase 4
27 Anti-Infective Agents, Local Phase 4
28 Dermatologic Agents Phase 4
29 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
30 Anti-Infective Agents Phase 4
31 Amoxicillin-Potassium Clavulanate Combination Phase 4
32 beta-Lactamase Inhibitors Phase 4
33 Cytochrome P-450 Enzyme Inhibitors Phase 4
34 Gastrointestinal Agents Phase 4
35 Cathartics Phase 4
36 Anti-Ulcer Agents Phase 4
37 Laxatives Phase 4
38 Antacids Phase 4
39
Histamine phosphate Phase 4 51-74-1 134614
40 Histamine H2 Antagonists Phase 4
41 Serotonin Receptor Agonists Phase 4
42 Histamine Antagonists Phase 4
43 Anesthetics Phase 4
44 Antibiotics, Antitubercular Phase 4
45 Anti-Bacterial Agents Phase 4
46 Analgesics Phase 4
47 Adrenergic alpha-Agonists Phase 4
48 Adrenergic Agonists Phase 4
49 Adrenergic Agents Phase 4
50 Neuromuscular Nondepolarizing Agents Phase 4

Interventional clinical trials:

(show all 44)
# Name Status NCT ID Phase Drugs
1 Effect of Oral Decontamination Using Chlorhexidine or Potassium Permanganate in ICU Patients: an Open-Labelled Randomized Controlled Trial Completed NCT00610324 Phase 4 Chlorhexidine gluconate;Potassium permanganate
2 Metoclopramide vs Placebo for Prevention of Pneumonia in Acute Stroke Patients Fed Via Nasogastric Tubes Completed NCT04873297 Phase 4 Metoclopramide 10mg;Placebo
3 PROcalcitonin Pneumonia / Pneumonitis Associated With ASPIration Completed NCT02862314 Phase 4
4 Antibiotic Prophylaxis in Critically Ill Patients After Suspected Aspiration Recruiting NCT05079620 Phase 4 Ceftriaxone;Amoxicillin clavulanic acid;Cefepime;Vancomycin;Levofloxacin
5 The Impact of Upper Gastrointestinal Dysmotility on Aspiration-associated Symptoms Not yet recruiting NCT05455359 Phase 4 Prucalopride;Famotidine
6 Eliminating Use of Non Depolarizing Neuromuscular Blocking Agents to Reduce Postoperative Pulmonary Complications: A Multi-center, Randomized Control Trial Suspended NCT03962725 Phase 4 Neuromuscular Blocking Agents;Anesthetic Adjuncts
7 Efficacy and Cost Efficacy of Prophylactic Treatment With Antibiotics During Concomitant Chemoradiotherapy in Patients With Locally Advanced Head and Neck Cancer to Prevent Aspiration Pneumonia. A Randomized Phase II-III Study Unknown status NCT01598402 Phase 2, Phase 3 amoxicillin/clavulanic acid suspension
8 Sellick Maneuver Evaluation in Rapid Sequence Induction of General Anesthesia Non Inferiority Trial Completed NCT02080754 Phase 3
9 Prospective, Multi-center, Randomized, Non-blind Trial to Assess the Efficacy and Safety of Moxifloxacin Versus Sulbactam/Ampicillin in the Treatment of Pulmonary Abscess and Aspiration Pneumonia Completed NCT01045902 Phase 3 Avelox (Moxifloxacin, BAY12-8039);Sulbactam/Ampicillin
10 The Randomized Inhaled Nitric Oxide Study (NINOS) in Full-Term and Nearly Full-Term Infants With Hypoxic Respiratory Failure Terminated NCT00005776 Phase 3 Inhaled nitric oxide;Placebo
11 Randomized Study of Two Interventions for Liquid Aspiration: Short-Term and Long-Term Effects Terminated NCT00000362 Phase 3
12 Early Inhaled Nitric Oxide Therapy in Term and Near Term Infants With Respiratory Failure Terminated NCT00005773 Phase 3 Inhaled Nitric Oxide;Standard iNO therapy
13 Validation of a Marker for Aspiration and Endotracheal Tube Cuff Leak. Withdrawn NCT02301845 Phase 1 Diatoms Shells
14 Ultrasound Assessment of Metoclopramide Effect on Gastric Volume in Patients Undergoing Cesarean Section: A Randomized, Double-blind, Cross-sectional Study" Unknown status NCT04157998 normal saline;Metoclopramide 10mg
15 Mechanical Ventilation During Cardiac Surgery, a Randomized Controlled Trial Unknown status NCT02090205
16 Impact of a Strategy Based on the Unyvero® Testing System on Appropriate Antimicrobial Treatment in Patients With Suspected Aspiration Pneumonia Requiring Mechanical Ventilation : a Randomized Controlled Unblinded Trial Unknown status NCT03763799
17 Salivary Alpha Amylase Bronchial Measure for Early Aspiration Pneumonia Diagnosis in Patients Treated With Therapeutic Hypothermia After Out-of-hospital Cardiac Arrest. Unknown status NCT03007862
18 Measuring the Effects of a Music Therapy Protocol on Respiratory and Bulbar Functions of Patients With Early and Mid-stage Amyotrophic Lateral Sclerosis: Mixed Methods Single Case Study Series Unknown status NCT03604822
19 Preoperative Fasting for Ambulatory Cataract Surgery: A Time-Interrupted Prospective Study Unknown status NCT03828500
20 Study of Risk Factors for Developing Inhalation Pneumonia After Inhalation Unknown status NCT03108430
21 Flexible Endoscopic Evaluation of Swallowing (FEES) to Determine Neurological Patients' Oral Diet Completed NCT03753841
22 Bedside Gastric Ultrasound for Preoperative Assessment of Gastric Content in Diabetic Patients Following ASA Fasting Guidelines Completed NCT04181814
23 Functionality and Accuracy of the smARTrack System in Real-Life ICU Settings Completed NCT02705781
24 Nutrition Monitoring and Feeding Optimization With the smART+ System Completed NCT04098224
25 The Effect of Continuous vs Enteral Pump Feeding in Aspiration in Tube Fed Patients Completed NCT00164957
26 Efficacy of Surface Landmark Palpation for Identification of the Cricoid Cartilage in Obstetric Patients Completed NCT02416219
27 Classification of Dysphagia Patients at Risk of Aspiration Pneumonia Using Machine Learning Algorithms Incorporating Acoustic Features From Phonetic Evaluation Completed NCT05098808
28 Evaluation of Gastric Residual Volume in Fasting Obese Patients Using Gastric Ultrasound: a Comparative Study Completed NCT04544371
29 The Effect of Semi-solid Feeding After Percutaneous Endoscopic Gastrostomy (PEG) on Clinical Outcomes, Specifically the Incidence of Aspiration Pneumonia and Postoperative Length of Stay Completed NCT02858596
30 Assessing Gastric Motility and Distention in Postoperative Gastrointestinal Surgery Using Bedside Gastric Ultrasound: Predicting Risk of Aspiration Pneumonia, Ileus, Return of Bowel Function Completed NCT04747691
31 Syndrome and Aspiration Pneumonia in Intensive Care Completed NCT01881672
32 The Efficacy and Safety of Gastric Feeding in Critically Ill Pediatric Patients Receiving Non-invasive Positive Pressure Ventilation: A Pilot Study Completed NCT01301352
33 Change of Regional Ventilation During Spontaneous Breathing After Lung Surgery Completed NCT02779595
34 Perioperative Change of Regional Ventilation During Spontaneous Breathing Completed NCT02419196
35 Evaluation of the Effectiveness and Safety of an Own-invention System for Continuous Supraglottic Aspiration in Intubated and Mechanically Ventilated Patients: the "SUPRAtube" Device Completed NCT03573635
36 Redefining Community Acquired Pneumonia in Older Adults: The Role and Impact of Aspiration Recruiting NCT04709978
37 The Cricoid Force Necessary to Occlude the Esophageal Entrance in Pediatric Patients Enrolling by invitation NCT05290844
38 Gastric Ultrasound in Critically Ill Patients for Evaluation of Gastric Volume Residuals; A Comparison of NPO Protocols Not yet recruiting NCT05526105
39 Slow-Stream Expiratory Muscle Strength Training for Veterans With Dysphagia Living in Long-term Care Not yet recruiting NCT04064333
40 Nocturnal Nasal Continuous Positive Airway Pressure in Aspiration Pneumonia Terminated NCT03844568
41 Functionality and Accuracy of the smART System in Real-Life ICU Settings Terminated NCT03689985
42 Intra-laryngeal Implant for Treatment of Chronic Aspirations Withdrawn NCT03325725
43 Dynamic Laryngotracheal Separation for Aspiration. Prevention of Silent Aspiration Pneumonia During Swallowing by an Implanted Stimulator Withdrawn NCT00580346
44 Detection of Silent Aspiration Events Utilizing pH/Impedance Probes in Hospitalized Patients Withdrawn NCT02720029

Search NIH Clinical Center for Aspiration Pneumonia

Cochrane evidence based reviews: pneumonia, aspiration

Sources

Genetic Tests for Aspiration Pneumonia

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Genetic tests related to Aspiration Pneumonia:

# Genetic test Affiliating Genes
1 Aspiration Pneumonia 28
Sources

Anatomical Context for Aspiration Pneumonia

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Organs/tissues related to Aspiration Pneumonia:

MalaCards : Lung, Liver, Tongue, Spinal Cord, Brain, Medulla Oblongata, Subthalamic Nucleus
Sources

Publications for Aspiration Pneumonia

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Articles related to Aspiration Pneumonia:

(show top 50) (show all 4818)
# Title Authors PMID Year
1
Aspiration pneumonia and primary lung abscess: diagnosis and therapy of an aerobic or an anaerobic infection? 53 62
20477271 2007
2
Neurocritical Care Aspects of Ischemic Stroke Management. 62
36333037 2023
3
Utilizing procalcitonin in a clinical setting to help differentiate between aspiration pneumonia and aspiration pneumonitis. 62
36308801 2023
4
Relationship Between Start of Feeding and Functional Outcome in Aspiration Pneumonia: A Retrospective Cohort Study. 62
36227574 2022
5
Preliminary study evaluating the assessment of changes in pulmonary function associated with body positioning in dogs with suspected aspiration pneumonia. 62
36468292 2022
6
Mortality from Aspiration Pneumonia: Incidence, Trends, and Risk Factors. 62
35099619 2022
7
Enhancing respiratory disease diagnosis by bronchoalveolar lavage in Kashmir: an audit of findings. 62
35948407 2022
8
Central nervous system mucormycosis in a patient with hematological malignancy: A case report and review of the literature. 62
35963603 2022
9
Sarcopenic dysphagia and aspiration pneumonia in older people. 62
36320152 2022
10
Clinical Outcomes and Patient Safety of Nasogastric Tube in Acute Stroke Patients. 62
35296916 2022
11
The characteristics of dysphagia and the incidence of pneumonia in Myotonic dystrophy type 1 patients especially concerning swallowing function evaluated by endoscopy. 62
35428520 2022
12
Characteristics of Dysphagia Based on the Type of ALS in Korean Patients Evaluated Using Videofluoroscopic Study: A Retrospective Analysis. 62
35304623 2022
13
A case of V180I genetic mutation Creutzfeldt Jakob disease (CJD) with delusional misidentification as an initial symptom. 62
34965177 2022
14
Perioperative Decrease in Tongue Pressure is an Intervenable Predictor of Aspiration After Esophagectomy. 62
36456848 2022
15
Outcomes of Aspiration Prevention Surgery: A Retrospective Cohort Study Using a Japanese Claims Database. 62
35171322 2022
16
Food-Grade Activated Charcoal for Contrast-Enhanced Photoacoustic Imaging of Aspiration: A Phantom Study. 62
35224656 2022
17
The effects of psychosocial determinants on post-operative complications of head and neck free flap patients. 62
36473263 2022
18
A New Therapeutic Approach for Dystussia and Atussia in Neurogenic Dysphagia: Effect of Aerosolized Capsaicin on Peak Cough Flow. 62
35430718 2022
19
Management and outcomes of 13 dogs treated with a modified Heller myotomy and Dor fundoplication for lower esophageal sphincter achalasia-like syndrome. 62
36458673 2022
20
Accidental organophosphate poisoning: A case series of 2 pediatric coumaphos exposures. 62
36474706 2022
21
Improving 30-day mortality after PEG tube placement in England from 2007 to 2019: a retrospective national cohort analysis of 87,862 patients. 62
35798054 2022
22
Safety and Benefits of Intraoperative Enteral Nutrition in Critically Ill Pediatric Burn Patients: A Systematic Review and Pooled Analysis. 62
35304893 2022
23
Development of the European Portuguese version of the oral health assessment tool: Content validity and reliability study in an elderly population. 62
35397193 2022
24
Pharmacokinetics and anti-nausea effects of intravenous ondansetron in hospitalized dogs exhibiting clinical signs of nausea. 62
35899472 2022
25
Use of the dental formula from the National Database of Health Insurance Claims and Specific Health Checkups of Japan. 62
35140822 2022
26
Autonomous Swallow Segment Extraction Using Deep Learning in Neck-Sensor Vibratory Signals from Patients With Dysphagia. 62
36417738 2022
27
A novel stapler-assisted technique for closure of persistent tracheoesophageal puncture fistula. 62
36345612 2022
28
Rehabilitating Cough Dysfunction in Parkinson's Disease: A Randomized Controlled Trial. 62
36345090 2022
29
Leptomeningeal carcinomatosis in a patient with recurrent unresectable squamous cell carcinoma of the retromolar trigone-a brief report. 62
36336772 2022
30
Cost-effectiveness of professional and mechanical oral care for preventing pneumonia in nursing home residents. 62
36334034 2022
31
Outcome in 38 dogs surgically treated for hepatic abscessation. 62
36413335 2022
32
Technology for maintaining oral care after stroke: considerations for patient-centered practice. 62
32988252 2022
33
Clinical significance of sarcopenic dysphagia for patients with esophageal cancer undergoing esophagectomy: A review. 62
36338588 2022
34
Schizophrenia, but not depression or bipolar affective disorder, adds additional risk of aspiration pneumonia among stroke survivors: A national cohort study in Taiwan. 62
36115193 2022
35
In-patient comorbidities in inclusion body myositis: a United States national in-patient sample-based study. 62
36377563 2022
36
Treatment of Severe Swallowing Dysfunction in Systemic Sclerosis with IVIG: Role of Antimuscarinic Antibodies. 62
36431141 2022
37
Orthogeriatric co-management at a regional core hospital as a new multidisciplinary approach in Japanese hip fracture operation. 62
36446671 2022
38
Development and implementation of an aspiration pneumonia cause investigation algorithm. 62
36373578 2022
39
Response to letter regarding "Comparison of lung ultrasound, chest radiographs, C-reactive protein, and clinical findings in dogs treated for aspiration pneumonia". 62
36189851 2022
40
An Autopsy Report of a Case with Cerebral Infarction Complicated by Coronavirus Disease 2019 Infection. 62
36070957 2022
41
Role of Hemodialysis in Acute Severe Alcohol Intoxication: A Meta-Analysis. 62
36450226 2022
42
Efficacy and safety of self-expandable metal stent placement for treatment of primary and metastatic gastric outlet obstruction. 62
36441448 2022
43
Myopathic dysphagia caused by thyrotoxicosis: a case report and review of the literature. 62
36448823 2022
44
Use of Maximum Tongue Pressure Values to Examine the Presence of Dysphagia after Extubation and Prevent Aspiration Pneumonia in Elderly Emergency Patients. 62
36362827 2022
45
Computed tomographic findings in dogs with suspected aspiration pneumonia: 38 cases (2014-2019). 62
36428285 2022
46
The association between empiric antimicrobial therapy and the risk of clinical failure in critically ill patients with aspiration pneumonia. 62
36096493 2022
47
Letter regarding "Comparison of lung ultrasound, chest radiographs, C-reactive protein, and clinical findings in dogs treated for aspiration pneumonia". 62
36178173 2022
48
Bacterial Aspiration Pneumonia in Generalized Convulsive Status Epilepticus: Incidence, Associated Factors and Outcome. 62
36431150 2022
49
Death of a child following a superstitious ritual of exorcism. 62
36370647 2022
50
Cause-specific mortalities in Korea during the first year of the COVID-19 pandemic. 62
36470264 2022
Sources

Variations for Aspiration Pneumonia

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ClinVar genetic disease variations for Aspiration Pneumonia:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 CHAT NM_020549.5(CHAT):c.2081C>G (p.Ser694Cys) SNV Pathogenic
 523529 rs201439531 GRCh37: 10:50872926-50872926
GRCh38: 10:49664880-49664880
2 CHAT NM_020549.5(CHAT):c.1061C>T (p.Thr354Met) SNV Pathogenic
 523528 rs769234940 GRCh37: 10:50835781-50835781
GRCh38: 10:49627735-49627735
Sources

Expression for Aspiration Pneumonia

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Search GEO for disease gene expression data for Aspiration Pneumonia.
Sources

Pathways for Aspiration Pneumonia

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Pathways related to Aspiration Pneumonia according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Sudden infant death syndrome (SIDS) susceptibility pathways 74
11.91 TNF TAC1 IL6 CHAT
2
Dendritic Cells Developmental Lineage Pathway 65
11.56 TNF IL6 CD4
3
Extrafollicular B cell activation by SARS-CoV-2 74
11.52 TNF IL6 CRP
4
IL 10 signaling pathway 67
11.45 TNF PIK3C2A IL6
5
Nonalcoholic fatty liver disease 74
11.27 TNF INS IL6
6
FOXA2 and FOXA3 transcription factor networks 61
Show member pathways
 11.18 INS F2 ALB
7
Heparin-induced Thrombocytopenia Pathway, Adverse Drug Reaction 60
11.07 F3 F2 CD4
8
Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway 74
10.91 TNF IL6 ACE2
9
Network map of SARS-CoV-2 signaling pathway 74
Show member pathways
 10.81 IL6 CRP CD4 ACE2
10
Cytokines and inflammatory response 74
10.79 TNF IL6 CD4
11
COVID-19 adverse outcome pathway 74
10.52 IL6 ACE2
12
Overview of nanoparticle effects 74
10.41 TNF IL6 CRP
13
Cells and molecules involved in local acute inflammatory response 74
Show member pathways
 10.16 TNF IL6
Sources

GO Terms for Aspiration Pneumonia

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Cellular components related to Aspiration Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.22 TNF TAC1 SNCA SERPINA3 INS IL6
2 extracellular space GO:0005615 9.75 TNF TAC1 SNCA SERPINA3 INS IL6
3 endoplasmic reticulum lumen GO:0005788 9.73 ACE2 ALB CD4 F2 IL6 INS

Biological processes related to Aspiration Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 9.73 TNF IL6 F2
2 negative regulation of lipid storage GO:0010888 9.63 TNF IL6 CRP
3 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.62 ACE2 ACE
4 regulation of transmembrane transporter activity GO:0022898 9.43 SNCA INS ACE2
5 acute-phase response GO:0006953 9.32 SERPINA3 INS IL6 F2 CRP

Molecular functions related to Aspiration Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 P-type potassium:proton transporter activity GO:0008900 9.26 ATP4A ATP12A
2 P-type potassium transmembrane transporter activity GO:0008556 9.16 ATP4A ATP12A
3 peptidyl-dipeptidase activity GO:0008241 8.92 ACE2 ACE
Sources

Sources for Aspiration Pneumonia

About this section
2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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