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MCID: ASP008
MIFTS: 42

Aspiration Pneumonitis

Categories: Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Aspiration Pneumonitis

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MalaCards integrated aliases for Aspiration Pneumonitis:

Name: Aspiration Pneumonitis 12 15 71
Mendelson's Syndrome Resulting from a Procedure 71
Pneumonitis Due to Fumes and/or Vapors 71
Aspiration Pneumonia 71
Chemical Pneumonitis 12
Mendelson's Syndrome 12
Toxic Pneumonitis 71

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:3240
MeSH 44 D011015
SNOMED-CT 67 47839005
UMLS 71 C0032290 C0264458 C0340150 more
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Summaries for Aspiration Pneumonitis

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Disease Ontology : 12 A pneumonia that is defined as an acute lung injury after the inhalation of foreign material such as regurgitated acidic gastric contents, petroleum products and laxative oils. This syndrome occurs in patients who have a marked disturbance of consciousness such as that resulting from a drug overdose, seizures, a massive cerebrovascular accident, or the use of anesthesia. Aspiration of gastric contents results in a chemical burn of the tracheobronchial tree and pulmonary parenchyma, causing an intense parenchymal inflammatory reaction. The disease has symptom non-productive cough, has symptom tachypnea, has symptom bronchospasm, has symptom bloody sputum, has symptom frothy sputum, or has symptom respiratory distress, 2-5 hrs after aspiration.

MalaCards based summary : Aspiration Pneumonitis, also known as mendelson's syndrome resulting from a procedure, is related to lipid pneumonia and aspiration pneumonia, and has symptoms including tachypnea, respiratory distress and bronchospasm. An important gene associated with Aspiration Pneumonitis is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Folate Metabolism and AGE-RAGE signaling pathway in diabetic complications. The drugs Amoxicillin and Clavulanate have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and tongue, and related phenotype is digestive/alimentary.

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Related Diseases for Aspiration Pneumonitis

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Diseases related to Aspiration Pneumonitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 592)
# Related Disease Score Top Affiliating Genes
1 lipid pneumonia 31.8 SP110 CRP COPA
2 aspiration pneumonia 30.6 TNF SERPINA3 F3 CRP ATP4A ATP12A
3 tracheomalacia 30.1 ATP4A ATP12A
4 bronchiolitis obliterans 29.9 TNF CXCL8 CRP
5 sarcoidosis 1 29.8 TNF SERPINA3 CRP
6 constipation 29.7 CRP ATP4A ATP12A ALB
7 bronchiolitis 29.7 TNF CXCL8 CRP
8 pulmonary edema 29.6 TNF OXT CXCL8 CRP
9 pneumonia 29.6 TNF HRH2 CXCL8 CRP ALB
10 bronchitis 29.6 TNF CXCL8 CRP ALB
11 pain agnosia 29.6 TNF OXT ALB
12 gastroesophageal reflux 29.6 TNF HRH2 CXCL8
13 bronchiectasis 29.5 TNF SERPINA3 CXCL8 CRP
14 bronchopneumonia 29.4 TNF SERPINA3 CXCL8 CRP ALB
15 peptic ulcer disease 29.2 TNF HRH2 CXCL8 ATP4A ATP12A
16 persistent fetal circulation syndrome 29.2 TNF OXT CXCL8 ALB
17 respiratory failure 28.9 TNF SERPINA3 F3 CXCL8 CRP ALB
18 exanthem 28.5 TNF F3 CXCL8 CRP ATP4A ATP12A
19 vagus nerve disease 10.4 ATP4A ATP12A
20 scalp dermatosis 10.4 ATP4A ATP12A
21 hemangioma of intra-abdominal structure 10.4 ATP4A ATP12A
22 acquired gastric outlet stenosis 10.4 ATP4A ATP12A
23 lingual goiter 10.4 ATP4A ATP12A
24 displacement of cardia through esophageal hiatus 10.4 ATP4A ATP12A
25 bacterial esophagitis 10.4 ATP4A ATP12A
26 benzylpenicillin allergy 10.4 ATP4A ATP12A
27 cervix erosion 10.4 ATP4A ATP12A
28 angiodysplasia of intestine 10.4 ATP4A ATP12A
29 granulomatous gastritis 10.4 ATP4A ATP12A
30 laryngeal tuberculosis 10.4 ATP4A ATP12A
31 fungal esophagitis 10.4 ATP4A ATP12A
32 dieulafoy lesion 10.4 ATP4A ATP12A
33 esophagus melanoma 10.4 ATP4A ATP12A
34 cefuroxime allergy 10.4 ATP4A ATP12A
35 gastric gastrinoma 10.4 ATP4A ATP12A
36 pneumatosis cystoides intestinalis 10.4 ATP4A ATP12A
37 central nervous system origin vertigo 10.4 ATP4A ATP12A
38 rumination disorder 10.3 ATP4A ATP12A
39 acute laryngitis 10.3 ATP4A ATP12A
40 gastroduodenitis 10.3 ATP4A ATP12A
41 barbiturate abuse 10.3 ATP4A ATP12A
42 lymphocytic gastritis 10.3 ATP4A ATP12A
43 x-linked chondrodysplasia punctata 1 10.3 ATP4A ATP12A
44 xanthogranulomatous pyelonephritis 10.3 SERPINA3 CRP
45 gastric antral vascular ectasia 10.3 ATP4A ATP12A
46 outlet dysfunction constipation 10.3 ATP4A ATP12A
47 functional diarrhea 10.3 ATP4A ATP12A
48 squamous papillomatosis 10.3 ATP4A ATP12A
49 esophageal tuberculosis 10.3 ATP4A ATP12A
50 eosinophilic gastritis 10.3 ATP4A ATP12A

Graphical network of the top 20 diseases related to Aspiration Pneumonitis:



Diseases related to Aspiration Pneumonitis
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Symptoms & Phenotypes for Aspiration Pneumonitis

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Symptoms:

12
  • • tachypnea
  • • respiratory distress
  • • bronchospasm
  • • non-productive cough
  • • bloody sputum
  • • frothy sputum

MGI Mouse Phenotypes related to Aspiration Pneumonitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.1 ALB ATP12A ATP4A HRH2 OXT TNF
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Drugs & Therapeutics for Aspiration Pneumonitis

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Drugs for Aspiration Pneumonitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 2, Phase 3 26787-78-0 33613
2
Clavulanate Approved, Vet_approved Phase 2, Phase 3 58001-44-8 5280980
3
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
4
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
5
Moxifloxacin Approved, Investigational Phase 3 151096-09-2, 354812-41-2 152946
6
Sulbactam Approved Phase 3 68373-14-8
7
Ampicillin Approved, Vet_approved Phase 3 69-53-4 6249
8
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
9
Polyestradiol phosphate Approved Phase 3 28014-46-2
10 Antibiotics, Antitubercular Phase 2, Phase 3
11 Anti-Infective Agents Phase 3
12 Anti-Bacterial Agents Phase 3
13 Estradiol 3-benzoate Phase 3
14 Contraceptive Agents Phase 3
15 Contraceptives, Oral Phase 3
16 Contraceptives, Oral, Combined Phase 3
17 Estradiol 17 beta-cypionate Phase 3
18 beta-Lactamase Inhibitors Phase 3
19 Norgestimate, ethinyl estradiol drug combination Phase 3
20 Pharmaceutical Solutions Phase 2
21
Dopamine Approved 51-61-6, 62-31-7 681
22
Metoclopramide Approved, Investigational 364-62-5 4168
23 Liver Extracts
24 Anesthetics
25 Dopamine Agents
26 Gastrointestinal Agents
27 Dopamine Antagonists
28 Antiemetics
29 Neurotransmitter Agents

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Efficacy and Cost Efficacy of Prophylactic Treatment With Antibiotics During Concomitant Chemoradiotherapy in Patients With Locally Advanced Head and Neck Cancer to Prevent Aspiration Pneumonia. A Randomized Phase II-III Study Unknown status NCT01598402 Phase 2, Phase 3 amoxicillin/clavulanic acid suspension
2 Prospective, Multi-center, Randomized, Non-blind Trial to Assess the Efficacy and Safety of Moxifloxacin Versus Sulbactam/Ampicillin in the Treatment of Pulmonary Abscess and Aspiration Pneumonia Completed NCT01045902 Phase 3 Avelox (Moxifloxacin, BAY12-8039);Sulbactam/Ampicillin
3 Effect of Daikenchuto (TJ-100) on Intestinal Dysmotility and For the Prevention of Postoperative Paralytic Ileus in Patients Undergoing Pancreaticoduodenectomy: A Multicenter, Randomized, Placebo-Controlled Phase II Trial Unknown status NCT01607307 Phase 2 Oral/enteral TJ-100 solution;Oral/enteral placebo solution
4 Dynamic Laryngotracheal Separation for Aspiration. Prevention of Silent Aspiration Pneumonia During Swallowing by an Implanted Stimulator Suspended NCT00580346 Phase 1
5 Salivary Alpha Amylase Bronchial Measure for Early Aspiration Pneumonia Diagnosis in Patients Treated With Therapeutic Hypothermia After Out-of-hospital Cardiac Arrest. Unknown status NCT03007862
6 Cross Sectional Evaluation of Coughing Force in Stroke Patients With Severe Aspiration Completed NCT02080988
7 Evaluation du Dosage de l'Amylase Dans le Liquide Broncho Alveolaire Dans le Diagnostic précoce de la Pneumopathie d'Inhalation Infectieuse du Sujet Comateux intubé-ventilé. Completed NCT03182387
8 The Effect of Continuous vs Enteral Pump Feeding in Aspiration in Tube Fed Patients Completed NCT00164957
9 Evaluation of Gastric Residual Volume in Fasting Obese Patients Using Gastric Ultrasound: a Comparative Study Completed NCT04544371
10 Functionality and Accuracy of the smARTrack System in Real-Life ICU Settings Completed NCT02705781
11 Efficacy of Surface Landmark Palpation for Identification of the Cricoid Cartilage in Obstetric Patients Completed NCT02416219
12 Bedside Gastric Ultrasound for Preoperative Assessment of Gastric Content in Diabetic Patients Following ASA Fasting Guidelines Completed NCT04181814
13 Evaluation of the Effectiveness and Safety of an Own-invention System for Continuous Supraglottic Aspiration in Intubated and Mechanically Ventilated Patients: the "SUPRAtube" Device Completed NCT03573635
14 The Effect of Semi-solid Feeding After Percutaneous Endoscopic Gastrostomy (PEG) on Clinical Outcomes, Specifically the Incidence of Aspiration Pneumonia and Postoperative Length of Stay Completed NCT02858596
15 Syndrome and Aspiration Pneumonia in Intensive Care Completed NCT01881672
16 Impact of a Strategy Based on the Unyvero® Testing System on Appropriate Antimicrobial Treatment in Patients With Suspected Aspiration Pneumonia Requiring Mechanical Ventilation : a Randomized Controlled Unblinded Trial Recruiting NCT03763799
17 Nutrition Monitoring and Feeding Optimization With the smART+ System Recruiting NCT04098224
18 Ultrasound Assessment of Metoclopramide Effect on Gastric Volume in Patients Undergoing Cesarean Section: A Randomized, Double-blind, Cross-sectional Study" Recruiting NCT04157998 normal saline;Metoclopramide 10mg
19 Screen and Intervene : A Diagnostic Accuracy Study and A Randomized Controlled Trial for Postextubation Dysphagia Recruiting NCT03284892
20 Assessing Gastric Motility and Distention in Postoperative Gastrointestinal Surgery Using Bedside Gastric Ultrasound: Predicting Risk of Aspiration Pneumonia, Ileus, Return of Bowel Function Recruiting NCT04747691
21 Nocturnal Nasal Continuous Positive Airway Pressure in Aspiration Pneumonia Terminated NCT03844568
22 Functionality and Accuracy of the smART System in Real-Life ICU Settings Terminated NCT03689985
23 Intra-laryngeal Implant for Treatment of Chronic Aspirations Withdrawn NCT03325725

Search NIH Clinical Center for Aspiration Pneumonitis

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Genetic Tests for Aspiration Pneumonitis

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Anatomical Context for Aspiration Pneumonitis

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MalaCards organs/tissues related to Aspiration Pneumonitis:

40
Lung, Liver, Tongue, Bone Marrow, Skeletal Muscle
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Publications for Aspiration Pneumonitis

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Articles related to Aspiration Pneumonitis:

(show top 50) (show all 542)
# Title Authors PMID Year
1
Chronic Aspiration Pneumonitis Caused by Spontaneous Cerebrospinal Fluid Fistulae of the Skull Base. 61
32449957 2021
2
Is fasting still necessary prior to contrast-enhanced computed tomography? A randomized clinical study. 61
32901302 2021
3
Conservative treatment of exposed implant following anterior cervical instrumentation surgery - A case report and review of literature. 61
33576696 2021
4
Assessment of the Clinical Pulmonary Infection Scores for prediction of ventilator associated pneumonia in patients with out of hospital cardiac arrest. 61
32962955 2021
5
Life-threatening triclopyr poisoning due to diethylene glycol monoethyl ether solvent. 61
32336161 2021
6
Pulmonary Aspiration During Induction of General Anesthesia. 61
33393603 2020
7
Comparison of low and high inspiratory oxygen fraction added to lung-protective ventilation on postoperative pulmonary complications after abdominal surgery: A randomized controlled trial. 61
32836188 2020
8
[Barium contrast aspiration pneumonitis]. 61
32173044 2020
9
Pulmonary aspiration during procedural sedation for colonoscopy resulting from positional change managed without oral endotracheal intubation. 61
32666416 2020
10
Reflux as a Risk Factor for Morbidity after Pediatric Tonsillectomy: A National Cohort of Inpatients. 61
32681749 2020
11
H-type congenital tracheoesophageal fistula: Insights from 70 years of The Royal Children's Hospital experience. 61
32807528 2020
12
Perioperative Stroke and Readmissions Rates in Noncardiac Non-Neurologic Surgery. 61
32280000 2020
13
First case of paralytic ileus after endoscopic mucosal resection of caecal polyp. 61
32423855 2020
14
Aspiration Pneumonitis. 61
32610867 2020
15
An observational cohort study of numbers and causes of preventable general hospital admissions in people with and without intellectual disabilities in England. 61
32141168 2020
16
Effects of Sugammadex on Post-Operative Pulmonary Complications in Laparoscopic Gastrectomy: A Retrospective Cohort Study. 61
32344750 2020
17
Choking agents and chlorine gas - History, pathophysiology, clinical effects and treatment. 61
31811912 2020
18
Increased severity associated with tallowamine in acute glyphosate poisoning. 61
31169038 2020
19
Nursing Home-Associated Pneumonia, Part I: Diagnosis. 61
31178286 2020
20
Burden and spectrum of paediatric respiratory diseases at a referral hospital in North-Central Nigeria - A five year review. 61
32161704 2020
21
Dysphagia Screening for Pneumonia Prevention in a Cancer Hospital: Results of a Quality/Safety Initiative. 61
31791195 2020
22
Aspiration Pneumonitis Causing Respiratory Collapse in a Pregnant Patient Not in Labor. 61
31977784 2020
23
Adverse respiratory outcomes among head and neck cancer survivors in the Utah Cancer Survivors Study. 61
31721181 2020
24
Goal-directed haemodynamic therapy (GDHT) in surgical patients: systematic review and meta-analysis of the impact of GDHT on post-operative pulmonary complications. 61
33072306 2020
25
Liquid Mosquito Repellent Ingestion in Children. 61
31768860 2020
26
Invasive Aspergillosis After Non-Fatal Drowning. 61
32210640 2020
27
Pulmonary Complications of Opioid Overdose Treated With Naloxone. 61
31182316 2020
28
Predictive Factors of Postendoscopic Submucosal Dissection Electrocoagulation Syndrome and the Utility of Computed Tomography Scan after Esophageal Endoscopic Submucosal Dissection. 61
31412351 2020
29
Kerosene, Camphor, and Naphthalene Poisoning in Children. 61
32021004 2019
30
Respiratory complications and 30-day unplanned hospital readmissions in patients with epilepsy. 61
31750026 2019
31
Aspiration Pneumonitis Causing Respiratory Collapse in a Pregnant Patient Not in Labor. 61
31503154 2019
32
Indiscriminate Use of Antibiotics in Neurotrauma Patients Referred for Expert Neurosurgical Care in a Developing Country. 61
31831986 2019
33
The Effect of S-Adenosylmethionine Treatment on Neurobehavioral Phenotypes in Lesch-Nyhan Disease: A Case Report. 61
31607891 2019
34
Diffuse Villous Tumor Arising in Barrett's Esophagus Presenting With Aspiration Pneumonitis. 61
31737717 2019
35
Obstructive retrosternal goitre mimicking severe bronchial asthma in pregnancy. 61
31383679 2019
36
Spontaneous cerebrospinal fluid rhinorrhoea and aspiration pneumonitis following initiation of continuous positive airway pressure treatment for obstructive sleep apnoea. 61
31139415 2019
37
Inflammasome-Independent and Atypical Processing of IL-1β Contributes to Acid Aspiration-Induced Acute Lung Injury. 61
31109954 2019
38
Effect of Intraoperative High Positive End-Expiratory Pressure (PEEP) With Recruitment Maneuvers vs Low PEEP on Postoperative Pulmonary Complications in Obese Patients: A Randomized Clinical Trial. 61
31157366 2019
39
Science and fiction in critical care: established concepts with or without evidence? 61
31200737 2019
40
Myasthenic crisis following iodinated contrast material (iohexol) aspiration: a case report. 61
31146780 2019
41
Unusual case of intraoperative acute cor pulmonale during spine surgery. 61
30971611 2019
42
Preoperative fasting for ambulatory cataract surgery: asystematic review. 61
30975334 2019
43
Effect of Preemptive Acetaminophen Administered Within 1 Hour of General Anesthesia on Gastric Residual Volume and pH in Children. 61
30270047 2019
44
[Harmful biological agents in municipal waste thermal treatment plants]. 61
30653196 2019
45
Thin Patient, Fatty Liver. 61
31058022 2019
46
Intravenous Sedation in Arnold-Chiari Malformation With Respiratory Failure. 61
30883227 2019
47
Explosive Vomiting Associated with Proximal Colonic Distention during a Difficult Propofol-Assisted Colonoscopy. 61
31392065 2019
48
Accidental Pyrethroid Ingestion in Toddler: Near-Fatal Atypical Presentation and Successful Recovery. 61
31998671 2019
49
An autopsy based descriptive study of the spectrum of pulmonary lesions encountered in fetal deaths at a tertiary care center. 61
30303136 2018
50
Neuroleptic malignant syndrome in a young adult female at the university of Benin Teaching Hospital: a case report. 61
30603012 2018
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Variations for Aspiration Pneumonitis

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Expression for Aspiration Pneumonitis

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Search GEO for disease gene expression data for Aspiration Pneumonitis.
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Pathways for Aspiration Pneumonitis

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Pathways related to Aspiration Pneumonitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Folate Metabolism 1
Show member pathways
 11.59 TNF SERPINA3 CRP ALB
2
AGE-RAGE signaling pathway in diabetic complications 36
11.43 TNF F3 CXCL8
3
Overview of nanoparticle effects 1
10.08 TNF CXCL8 CRP
4
Secretion of Hydrochloric Acid in Parietal Cells 1
9.85 HRH2 ATP4A
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GO Terms for Aspiration Pneumonitis

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Cellular components related to Aspiration Pneumonitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 TNF SERPINA3 OXT F3 CXCL8 CRP
2 extracellular space GO:0005615 9.28 TNF SERPINA3 OXT F3 CXCL8 CRP

Biological processes related to Aspiration Pneumonitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.62 TNF SERPINA3 CXCL8 CRP
2 cellular sodium ion homeostasis GO:0006883 9.43 ATP4A ATP12A
3 positive regulation of synaptic transmission GO:0050806 9.4 TNF OXT
4 embryonic digestive tract development GO:0048566 9.37 TNF CXCL8
5 sodium ion export across plasma membrane GO:0036376 9.26 ATP4A ATP12A
6 cellular potassium ion homeostasis GO:0030007 9.16 ATP4A ATP12A
7 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.96 ATP4A ATP12A
8 negative regulation of lipid storage GO:0010888 8.62 TNF CRP

Molecular functions related to Aspiration Pneumonitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A
Sources

Sources for Aspiration Pneumonitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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