MCID: ASP036
MIFTS: 31

Aspirin Allergy

Categories: Immune diseases

Aliases & Classifications for Aspirin Allergy

MalaCards integrated aliases for Aspirin Allergy:

Name: Aspirin Allergy 12 15
Acetylsalicylic Acid Allergy 12
Asa Allergy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0040002
UMLS 74 C0004058

Summaries for Aspirin Allergy

Disease Ontology : 12 A drug allergy that has_allergic_trigger acetylsalicylic acid.

MalaCards based summary : Aspirin Allergy, also known as acetylsalicylic acid allergy, is related to myocardial infarction and posterior myocardial infarction. An important gene associated with Aspirin Allergy is ITGA2B (Integrin Subunit Alpha 2b), and among its related pathways/superpathways are ECM proteoglycans and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. The drugs Aspirin and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and endothelial, and related phenotypes are homeostasis/metabolism and renal/urinary system

Related Diseases for Aspirin Allergy

Diseases related to Aspirin Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 myocardial infarction 29.1 ITGA2B PTGS1 SERPINC1 SERPINE1
2 posterior myocardial infarction 10.2 SERPINC1 SULT1E1
3 inherited blood coagulation disease 10.2 ITGA2B SERPINC1
4 intracranial thrombosis 10.2 ITGA2B SERPINC1
5 intermediate coronary syndrome 10.1 ITGA2B SERPINC1
6 carotid artery thrombosis 10.1 ITGA2B SERPINE1
7 acute cor pulmonale 10.1 CA2 SERPINE1
8 branch retinal artery occlusion 10.0 SERPINC1 WDTC1
9 acute pulmonary heart disease 10.0 CA2 SERPINE1
10 fibrinolytic defect 10.0 SERPINC1 SERPINE1
11 argentine hemorrhagic fever 10.0 SERPINC1 SERPINE1
12 sticky platelet syndrome 10.0 SERPINC1 SERPINE1
13 blue toe syndrome 10.0 SERPINC1 SERPINE1
14 ischemic colitis 10.0 SERPINC1 SERPINE1
15 subendocardial myocardial infarction 10.0 SERPINC1 SERPINE1
16 livedoid vasculitis 10.0 SERPINC1 SERPINE1
17 thrombophlebitis 10.0 SERPINC1 SERPINE1
18 meningococcemia 10.0 SERPINC1 SERPINE1
19 post-thrombotic syndrome 10.0 SERPINC1 SERPINE1
20 legg-calve-perthes disease 10.0 SERPINC1 SERPINE1
21 asthma 10.0
22 retinal artery occlusion 10.0 SERPINC1 SERPINE1
23 portal vein thrombosis 10.0 SERPINC1 SERPINE1
24 coronary thrombosis 10.0 SERPINC1 SERPINE1
25 hepatic vascular disease 10.0 SERPINC1 SERPINE1
26 hepatic veno-occlusive disease 10.0 SERPINC1 SERPINE1
27 epileptic encephalopathy, childhood-onset 10.0 SERPINC1 SERPINE1
28 vein disease 9.9 SERPINC1 SERPINE1
29 intracranial hypertension 9.9 SERPINC1 SERPINE1
30 intermittent claudication 9.9 SERPINC1 SERPINE1
31 retinal vein occlusion 9.9 SERPINC1 SERPINE1
32 thrombophilia due to activated protein c resistance 9.9 SERPINC1 SERPINE1
33 thrombophilia 9.9 SERPINC1 SERPINE1
34 blood coagulation disease 9.9 ITGA2B SERPINC1 WDTC1
35 blood platelet disease 9.9 ITGA2B SERPINC1 WDTC1
36 osteonecrosis 9.9 SERPINC1 SERPINE1
37 purpura 9.9 ITGA2B SERPINC1
38 disseminated intravascular coagulation 9.9 SERPINC1 SERPINE1
39 thrombophilia due to thrombin defect 9.9 SERPINC1 SERPINE1
40 cerebrovascular disease 9.8
41 hemorrhagic disease 9.8 ITGA2B SERPINC1 SERPINE1
42 acute myocardial infarction 9.8 ITGA2B SERPINC1 SERPINE1
43 pulmonary embolism 9.8 SERPINC1 SERPINE1
44 peripheral vascular disease 9.8 SERPINC1 SERPINE1
45 hellp syndrome 9.6 SERPINC1 SERPINE1
46 arteries, anomalies of 9.5 ITGA2B SERPINC1 SERPINE1 WDTC1

Graphical network of the top 20 diseases related to Aspirin Allergy:



Diseases related to Aspirin Allergy

Symptoms & Phenotypes for Aspirin Allergy

MGI Mouse Phenotypes related to Aspirin Allergy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.7 CA2 ITGA2B PTGS1 SERPINC1 SERPINE1 SULT1E1
2 renal/urinary system MP:0005367 9.26 CA2 PTGS1 SERPINC1 SERPINE1
3 reproductive system MP:0005389 9.02 CA2 ITGA2B PTGS1 SERPINC1 SULT1E1

Drugs & Therapeutics for Aspirin Allergy

Drugs for Aspirin Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved 50-78-2 2244
2
Acetaminophen Approved 103-90-2 1983
3 Peripheral Nervous System Agents
4 Anti-Inflammatory Agents
5 Fibrinolytic Agents
6 Cyclooxygenase Inhibitors
7 Anti-Inflammatory Agents, Non-Steroidal
8 Antipyretics
9 Analgesics
10 Platelet Aggregation Inhibitors
11 Antirheumatic Agents
12 Analgesics, Non-Narcotic

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Diagnosis of Aspirin Hypersensitivity in Aspirin Exacerbated Respiratory Disease Completed NCT01320072
2 Characteristics of Patients Diagnosed With NSAID Sensitivity in Thailand Recruiting NCT03849625 aspirin, NSAIDs, paracetamol

Search NIH Clinical Center for Aspirin Allergy

Genetic Tests for Aspirin Allergy

Anatomical Context for Aspirin Allergy

MalaCards organs/tissues related to Aspirin Allergy:

42
Testes, Skin, Endothelial

Publications for Aspirin Allergy

Articles related to Aspirin Allergy:

(show all 22)
# Title Authors Year
1
Which Antiplatelet Therapy in Patients With Left Ventricular Assist Device and Aspirin Allergy? ( 29362190 )
2018
2
Rapid Aspirin Challenge in Patients with Aspirin Allergy and Acute Coronary Syndromes. ( 26758864 )
2016
3
Aspirin allergy in patients with myocardial infarction: the allergist's role. ( 24468245 )
2014
4
Aspirin allergy desensitization in cerebrovascular disease. A report of two cases, literature review and management guide for the neurointerventionalist. ( 24556294 )
2014
5
Safety of aspirin desensitization in patients with reported aspirin allergy and cardiovascular disease. ( 22990948 )
2013
6
Primary PCI with endothelial progenitor cell-capture stent in patient with skull base fracture and aspirin allergy. ( 23575723 )
2013
7
Cardiovascular prophylaxis and aspirin "allergy". ( 23639713 )
2013
8
Rapid desensitisation of patients with aspirin allergy who undergo coronary angioplasty. ( 21933761 )
2011
9
Rapid oral aspirin desensitization for patients with aspirin allergy requiring dual antiplatelet therapy. ( 18306836 )
2008
10
Clinical usefulness of cellular antigen stimulation test in detection of aspirin allergy. ( 16324421 )
2005
11
Approach to "aspirin allergy" in cardiovascular patients. ( 15238467 )
2004
12
Aspirin "allergy" and resistance. ( 15312890 )
2004
13
Thwarting an aspirin allergy. Aspirin can trigger allergy and asthma symptoms. Careful desensitization can hold them at bay. ( 15381494 )
2004
14
Aspirin allergy. ( 7469139 )
1981
15
Diagnostic significance of the passive hemagglutination tests in penicillin and aspirin allergy. ( 106406 )
1978
16
Aspirin allergy: a clinical study. ( 1118772 )
1975
17
Acute anaphylactic reactions and aspirin allergy. ( 4397023 )
1971
18
Aspirin allergy. ( 5090776 )
1971
19
Aspirin allergy. ( 13437244 )
1957
20
Aspirin allergy. ( 13346110 )
1956
21
The problem of aspirin allergy with a report on skin testing with salicylate-containing human sera. ( 14774620 )
1950
22
Aspirin allergy; its relationship to chronic intractable asthma. ( 20238915 )
1947

Variations for Aspirin Allergy

Expression for Aspirin Allergy

Search GEO for disease gene expression data for Aspirin Allergy.

Pathways for Aspirin Allergy

Pathways related to Aspirin Allergy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.71 ITGA2B SERPINE1
2 10.33 ITGA2B PTGS1

GO Terms for Aspirin Allergy

Cellular components related to Aspirin Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.02 CA2 ITGA2B PTGS1 SERPINC1 SERPINE1

Molecular functions related to Aspirin Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase inhibitor activity GO:0004867 8.62 SERPINC1 SERPINE1

Sources for Aspirin Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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