MCID: ASP036
MIFTS: 32

Aspirin Allergy

Categories: Immune diseases

Aliases & Classifications for Aspirin Allergy

MalaCards integrated aliases for Aspirin Allergy:

Name: Aspirin Allergy 12 15
Acetylsalicylic Acid Allergy 12
Asa Allergy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0040002
UMLS 72 C0004058

Summaries for Aspirin Allergy

Disease Ontology : 12 A drug allergy that has allergic trigger acetylsalicylic acid.

MalaCards based summary : Aspirin Allergy, also known as acetylsalicylic acid allergy, is related to coronary thrombosis and cerebrovascular disease. An important gene associated with Aspirin Allergy is ITGA2B (Integrin Subunit Alpha 2b), and among its related pathways/superpathways are Complement and coagulation cascades and Platelet activation. The drugs Morphine and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and skin, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Aspirin Allergy

Diseases related to Aspirin Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 coronary thrombosis 29.3 SERPINE1 SERPINC1
2 cerebrovascular disease 29.0 SERPINE1 ITGA2B
3 myocardial infarction 28.2 SERPINE1 SERPINC1 PTGS1 ITGA2B
4 arteries, anomalies of 28.2 WDTC1 SERPINE1 SERPINC1 ITGA2B
5 allergic hypersensitivity disease 10.2
6 urticaria 10.2
7 angioedema 10.2
8 intracranial thrombosis 10.1 SERPINC1 ITGA2B
9 inherited blood coagulation disease 10.1 SERPINC1 ITGA2B
10 intermediate coronary syndrome 10.1 SERPINC1 ITGA2B
11 hyperlipoproteinemia, type iii 10.0
12 coronary artery anomaly 10.0
13 branch retinal artery occlusion 10.0 WDTC1 SERPINC1
14 carotid artery thrombosis 10.0 SERPINE1 ITGA2B
15 asthma 9.9
16 asthma-related traits 2 9.9
17 vascular disease 9.9
18 ischemia 9.9
19 gastritis 9.9
20 rhinitis 9.9
21 acute cor pulmonale 9.8 SERPINE1 CA2
22 acute pulmonary heart disease 9.8 SERPINE1 CA2
23 purpura 9.8 SERPINC1 ITGA2B
24 fibrinolytic defect 9.8 SERPINE1 SERPINC1
25 sticky platelet syndrome 9.8 SERPINE1 SERPINC1
26 argentine hemorrhagic fever 9.8 SERPINE1 SERPINC1
27 blue toe syndrome 9.8 SERPINE1 SERPINC1
28 ischemic colitis 9.8 SERPINE1 SERPINC1
29 subendocardial myocardial infarction 9.8 SERPINE1 SERPINC1
30 thrombosis 9.8 SERPINE1 SERPINC1
31 livedoid vasculitis 9.8 SERPINE1 SERPINC1
32 meningococcemia 9.7 SERPINE1 SERPINC1
33 thrombophlebitis 9.7 SERPINE1 SERPINC1
34 post-thrombotic syndrome 9.7 SERPINE1 SERPINC1
35 retinal artery occlusion 9.7 SERPINE1 SERPINC1
36 legg-calve-perthes disease 9.7 SERPINE1 SERPINC1
37 portal vein thrombosis 9.7 SERPINE1 SERPINC1
38 blood coagulation disease 9.7 WDTC1 SERPINC1 ITGA2B
39 blood platelet disease 9.7 WDTC1 SERPINC1 ITGA2B
40 hepatic vascular disease 9.7 SERPINE1 SERPINC1
41 hepatic veno-occlusive disease 9.7 SERPINE1 SERPINC1
42 vein disease 9.7 SERPINE1 SERPINC1
43 epileptic encephalopathy, childhood-onset 9.7 SERPINE1 SERPINC1
44 intracranial hypertension 9.7 SERPINE1 SERPINC1
45 retinal vein occlusion 9.6 SERPINE1 SERPINC1
46 intermittent claudication 9.6 SERPINE1 SERPINC1
47 thrombophilia due to activated protein c resistance 9.6 SERPINE1 SERPINC1
48 thrombophilia 9.6 SERPINE1 SERPINC1
49 osteonecrosis 9.6 SERPINE1 SERPINC1
50 disseminated intravascular coagulation 9.6 SERPINE1 SERPINC1

Graphical network of the top 20 diseases related to Aspirin Allergy:



Diseases related to Aspirin Allergy

Symptoms & Phenotypes for Aspirin Allergy

MGI Mouse Phenotypes related to Aspirin Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.63 CA2 ITGA2B PTGS1 SERPINC1 SERPINE1 WDTC1
2 immune system MP:0005387 9.35 CA2 ITGA2B PTGS1 SERPINC1 SERPINE1
3 renal/urinary system MP:0005367 8.92 CA2 PTGS1 SERPINC1 SERPINE1

Drugs & Therapeutics for Aspirin Allergy

Drugs for Aspirin Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Morphine Approved, Investigational Phase 4 57-27-2 5288826
2
Ibuprofen Approved Phase 4 15687-27-1 3672
3 Analgesics Phase 4
4 Anti-Inflammatory Agents Phase 4
5 Analgesics, Non-Narcotic Phase 4
6 Cyclooxygenase Inhibitors Phase 4
7 Anti-Inflammatory Agents, Non-Steroidal Phase 4
8 Peripheral Nervous System Agents Phase 4
9 Antirheumatic Agents Phase 4
10
Omalizumab Approved, Investigational 242138-07-4
11
Aspirin Approved, Vet_approved 50-78-2 2244
12
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
13
Chitosan Experimental 9012-76-4 71853
14 Fibrinolytic Agents
15 Anti-Allergic Agents
16 Respiratory System Agents
17 Platelet Aggregation Inhibitors
18 Anti-Asthmatic Agents
19 Antipyretics
20 Antifungal Agents
21 Lipid Regulating Agents
22 Coagulants
23 Anti-Bacterial Agents
24 Pharmaceutical Solutions
25 Hemostatics
26 Hypolipidemic Agents
27 Anti-Infective Agents
28 Anticholesteremic Agents
29 Chelating Agents
30 Antimetabolites

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intravenous Ibuprofen for Laparoscopic Bariatric Surgery Completed NCT01707251 Phase 4 Intravenous Ibuprofen;Saline
2 Double Blind Study to Determine Effect of Omalizumab Treatment in Patients With the Co-Morbid Conditions of Aspirin Exacerbated Respiratory Disease(AERD) and Allergic Asthma and Rhinitis. Unknown status NCT00286416 omalizumab (Xolair)
3 Comparison of Nasal Saline Irrigation Bottle Contamination Between Two Solutions Unknown status NCT02413125 Normal saline

Search NIH Clinical Center for Aspirin Allergy

Genetic Tests for Aspirin Allergy

Anatomical Context for Aspirin Allergy

MalaCards organs/tissues related to Aspirin Allergy:

41
Testes, Heart, Skin, Endothelial, T Cells

Publications for Aspirin Allergy

Articles related to Aspirin Allergy:

(show top 50) (show all 64)
# Title Authors PMID Year
1
Validation of a claims-based algorithm identifying eligible study subjects in the ADAPTABLE pragmatic clinical trial. 38
30480162 2018
2
Prognosis of Chronic Rhinosinusitis With Nasal Polyps Using Preoperative Eosinophil/Basophil Levels and Treatment Compliance. 38
30112918 2018
3
Which Antiplatelet Therapy in Patients With Left Ventricular Assist Device and Aspirin Allergy? 38
29362190 2018
4
Kounis syndrome induced by oral intake of aspirin: case report and literature review. 38
30637085 2018
5
Utility of low-dose oral aspirin challenges for diagnosis of aspirin-exacerbated respiratory disease. 38
26822279 2016
6
If worst comes to horrible - sealing an iatrogenic coronary perforation with a polytetrafluoroethylene-covered stent in a patient with aspirin intolerance. 38
26865577 2016
7
Rapid Aspirin Challenge in Patients with Aspirin Allergy and Acute Coronary Syndromes. 38
26758864 2016
8
Short-term ibuprofen treatment and pulmonary function in children with asthma. 38
26388628 2015
9
[Anaphylactic reaction to intravenous glucocorticoid in a patient with chronic obstructive pulmonary disease]. 38
25872602 2015
10
Aspirin allergy in patients with myocardial infarction: the allergist's role. 38
24468245 2014
11
Aspirin allergy desensitization in cerebrovascular disease. A report of two cases, literature review and management guide for the neurointerventionalist. 38
24556294 2014
12
The utility of using fiberoptic rhinoscopy in the diagnosis of nasal polyps. 38
24274928 2013
13
Peripheral T-cell lymphoma mimicking 5-aminosalicylate hypersensitivity in ulcerative colitis. 38
24134170 2013
14
Cardiovascular prophylaxis and aspirin "allergy". 38
23639713 2013
15
A case of type I variant Kounis syndrome with Samter-Beer triad. 38
23675559 2013
16
Aspirin desensitization in patients undergoing percutaneous coronary intervention: a survey of current practice. 38
23558870 2013
17
Primary PCI with endothelial progenitor cell-capture stent in patient with skull base fracture and aspirin allergy. 38
23575723 2013
18
Safety of aspirin desensitization in patients with reported aspirin allergy and cardiovascular disease. 38
22990948 2013
19
Rapid desensitisation of patients with aspirin allergy who undergo coronary angioplasty. 38
21933761 2011
20
Willow species and aspirin: different mechanism of actions. 38
21226125 2011
21
The Kounis-Zavras syndrome with the Samter-Beer triad. 38
21566756 2011
22
A novel drug-eluting stent using bioabsorbable polymer technology: two-year follow-up of the CURAMI registry. 38
17942172 2009
23
Safety and tolerability of 600 mg clopidogrel bolus in patients with acute ischemic stroke: preliminary experience. 38
18830204 2008
24
[The relationship between smoking and nasal polyposis]. 38
19052488 2008
25
[Epidemiological characteristics, distribution of allergens, and symptom severity in patients with perennial allergic rhinitis, living in Konya region]. 38
19052490 2008
26
The primary and secondary prevention of coronary artery disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). 38
18574278 2008
27
Rapid oral aspirin desensitization for patients with aspirin allergy requiring dual antiplatelet therapy. 38
18306836 2008
28
An economic analysis of aspirin desensitization in aspirin-exacerbated respiratory disease. 38
17716716 2008
29
Rapid desensitization protocols for patients with cardiovascular disease and aspirin hypersensitivity in an era of dual antiplatelet therapy. 38
17200429 2007
30
The rate of checking urine microalbumin and aspirin primary prevention in type 2 DM. 38
16756047 2006
31
Worsening of asthma with systemic corticosteroids. A case report and review of literature. 38
16606375 2006
32
Underutilization of aspirin in hemodialysis patients for primary and secondary prevention of cardiovascular disease. 38
16312265 2005
33
Evaluation of presence of aspirin-related warnings with willow bark. 38
15928264 2005
34
Clinical usefulness of cellular antigen stimulation test in detection of aspirin allergy. 38
16324421 2005
35
Aspirin sensitivity: implications for patients with coronary artery disease. 38
15613671 2004
36
Antithrombotic therapy for coronary artery disease: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. 38
15383483 2004
37
Thwarting an aspirin allergy. Aspirin can trigger allergy and asthma symptoms. Careful desensitization can hold them at bay. 38
15381494 2004
38
Aspirin "allergy" and resistance. 38
15312890 2004
39
Approach to "aspirin allergy" in cardiovascular patients. 38
15238467 2004
40
Antiplatelet agents for the prevention of cardiovascular disease in diabetes mellitus. 38
15049721 2004
41
The platelet in diabetes: focus on prevention of ischemic events. 38
12832332 2003
42
Anaphylactic reaction to a dietary supplement containing willow bark. 38
12773073 2003
43
Antiplatelet therapy from clinical trials to clinical practice. 38
15931295 2003
44
Prophylaxis of the antiphospholipid syndrome: a consensus report. 38
12892387 2003
45
Treatment for the procoagulant state in type 2 diabetes. 38
11727398 2001
46
New recommendations from the 1999 American College of Cardiology/American Heart Association acute myocardial infarction guidelines. 38
11346067 2001
47
[Aspirin: allergy or intolerance]. 38
10763208 2000
48
COX-2 inhibitors and dental pain control. 38
10825891 1999
49
Transient dilatation of the abdominal aorta in an infant with Kawasaki disease associated with thrombocytopenia. 38
7572158 1995
50
Medical and surgical management of sinusitis in adults. 38
1728900 1992

Variations for Aspirin Allergy

Expression for Aspirin Allergy

Search GEO for disease gene expression data for Aspirin Allergy.

Pathways for Aspirin Allergy

Pathways related to Aspirin Allergy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 SERPINE1 SERPINC1
2 11.25 PTGS1 ITGA2B
3 10.71 SERPINE1 ITGA2B
4 10.33 PTGS1 ITGA2B

GO Terms for Aspirin Allergy

Cellular components related to Aspirin Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.02 SERPINE1 SERPINC1 PTGS1 ITGA2B CA2

Biological processes related to Aspirin Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 8.96 SERPINE1 ITGA2B
2 negative regulation of peptidase activity GO:0010466 8.62 SERPINE1 SERPINC1

Molecular functions related to Aspirin Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase inhibitor activity GO:0030414 9.16 SERPINE1 SERPINC1
2 protease binding GO:0002020 8.96 SERPINE1 SERPINC1
3 serine-type endopeptidase inhibitor activity GO:0004867 8.62 SERPINE1 SERPINC1

Sources for Aspirin Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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