MCID: ASP036
MIFTS: 30

Aspirin Allergy

Categories: Immune diseases

Aliases & Classifications for Aspirin Allergy

MalaCards integrated aliases for Aspirin Allergy:

Name: Aspirin Allergy 12 15
Acetylsalicylic Acid Allergy 12
Asa Allergy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0040002
UMLS 71 C0004058

Summaries for Aspirin Allergy

Disease Ontology : 12 A drug allergy that has allergic trigger acetylsalicylic acid.

MalaCards based summary : Aspirin Allergy, also known as acetylsalicylic acid allergy, is related to coronary thrombosis and qualitative platelet defect. An important gene associated with Aspirin Allergy is ITGA2B (Integrin Subunit Alpha 2b), and among its related pathways/superpathways are Platelet activation and Hematopoietic Stem Cell Differentiation. The drugs Ibuprofen and Morphine have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and skin, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Aspirin Allergy

Diseases related to Aspirin Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 coronary thrombosis 29.4 WDTC1 P2RY12 ITGA2B
2 qualitative platelet defect 10.2 WDTC1 ITGA2B
3 carotid artery thrombosis 10.2 WDTC1 ITGA2B
4 allergic hypersensitivity disease 10.2
5 urticaria 10.2
6 angioedema 10.2
7 orange allergy 10.2 WDFY2 TPO
8 intracranial arteriosclerosis 10.1 TPO EEF1A2
9 intracranial thrombosis 10.1 WDTC1 ITGA2B
10 inherited blood coagulation disease 10.1 WDTC1 ITGA2B
11 torsion dystonia 2 10.1 TPO TGM2
12 blood coagulation disease 10.0 WDTC1 ITGA2B
13 hyperlipoproteinemia, type iii 10.0
14 coronary artery anomaly 10.0
15 dystonia 25 10.0 TPO TGM2
16 bleeding disorder, platelet-type, 8 10.0 WDTC1 P2RY12
17 left bundle branch hemiblock 10.0 P2RY12 ITGA2B
18 gray platelet syndrome 9.9 WDTC1 ITGA2B
19 gas gangrene 9.9 P2RY12 EEF1A2
20 arteries, anomalies of 9.9
21 asthma 9.9
22 myocardial infarction 9.9
23 asthma-related traits 2 9.9
24 vascular disease 9.9
25 ischemia 9.9
26 gastritis 9.9
27 rhinitis 9.9
28 cerebrovascular disease 9.9
29 active peptic ulcer disease 9.8 PTGS1 P2RY12
30 autoimmune disease of gastrointestinal tract 9.8 TPO TGM2
31 blood platelet disease 9.8 WDTC1 PTGS1 ITGA2B
32 limbic encephalitis 9.8 TPO PPP1R9B
33 bernard-soulier syndrome 9.8 WDTC1 ITGA2B
34 intermediate coronary syndrome 9.5 WDTC1 P2RY12 ITGA2B EEF1A2
35 hypertension, essential 9.0 WDTC1 PTGS1 P2RY12 ITGA2B EEF1A2

Graphical network of the top 20 diseases related to Aspirin Allergy:



Diseases related to Aspirin Allergy

Symptoms & Phenotypes for Aspirin Allergy

MGI Mouse Phenotypes related to Aspirin Allergy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 EEF1A2 ITGA2B P2RY12 PPP1R9B PTGS1 TGM2
2 homeostasis/metabolism MP:0005376 9.23 ACOT11 ITGA2B P2RY12 PPP1R9B PTGS1 TGM2

Drugs & Therapeutics for Aspirin Allergy

Drugs for Aspirin Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ibuprofen Approved Phase 4 15687-27-1 3672
2
Morphine Approved, Investigational Phase 4 57-27-2 5288826
3 Anti-Inflammatory Agents Phase 4
4 Anti-Inflammatory Agents, Non-Steroidal Phase 4
5 Analgesics, Non-Narcotic Phase 4
6 Cyclooxygenase Inhibitors Phase 4
7 Antirheumatic Agents Phase 4
8 Analgesics Phase 4
9
Aspirin Approved, Vet_approved 50-78-2 2244
10
Omalizumab Approved, Investigational 242138-07-4
11
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
12
Chitosan Experimental 9012-76-4 71853
13 Fibrinolytic Agents
14 Respiratory System Agents
15 Platelet Aggregation Inhibitors
16 Antipyretics
17 Anti-Asthmatic Agents
18 Anti-Allergic Agents
19 Hypolipidemic Agents
20 Pharmaceutical Solutions
21 Anticholesteremic Agents
22 Anti-Bacterial Agents
23 Antifungal Agents
24 Chelating Agents
25 Coagulants
26 Hemostatics
27 Lipid Regulating Agents
28 Anti-Infective Agents
29 Antimetabolites

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intravenous Ibuprofen for Laparoscopic Bariatric Surgery Completed NCT01707251 Phase 4 Intravenous Ibuprofen;Saline
2 Double Blind Study to Determine Effect of Omalizumab Treatment in Patients With the Co-Morbid Conditions of Aspirin Exacerbated Respiratory Disease(AERD) and Allergic Asthma and Rhinitis. Unknown status NCT00286416 omalizumab (Xolair)
3 Comparison of Nasal Saline Irrigation Bottle Contamination Between Two Solutions Unknown status NCT02413125 Normal saline

Search NIH Clinical Center for Aspirin Allergy

Genetic Tests for Aspirin Allergy

Anatomical Context for Aspirin Allergy

MalaCards organs/tissues related to Aspirin Allergy:

40
Testes, Heart, Skin, T Cells, Endothelial

Publications for Aspirin Allergy

Articles related to Aspirin Allergy:

(show top 50) (show all 65)
# Title Authors PMID Year
1
Acute severe asthma (status asthmaticus). 61
31690381 2019
2
Validation of a claims-based algorithm identifying eligible study subjects in the ADAPTABLE pragmatic clinical trial. 61
30480162 2018
3
Prognosis of Chronic Rhinosinusitis With Nasal Polyps Using Preoperative Eosinophil/Basophil Levels and Treatment Compliance. 61
30112918 2018
4
Which Antiplatelet Therapy in Patients With Left Ventricular Assist Device and Aspirin Allergy? 61
29362190 2018
5
Kounis syndrome induced by oral intake of aspirin: case report and literature review. 61
30637085 2018
6
Utility of low-dose oral aspirin challenges for diagnosis of aspirin-exacerbated respiratory disease. 61
26822279 2016
7
If worst comes to horrible - sealing an iatrogenic coronary perforation with a polytetrafluoroethylene-covered stent in a patient with aspirin intolerance. 61
26865577 2016
8
Rapid Aspirin Challenge in Patients with Aspirin Allergy and Acute Coronary Syndromes. 61
26758864 2016
9
Short-term ibuprofen treatment and pulmonary function in children with asthma. 61
26388628 2015
10
[Anaphylactic reaction to intravenous glucocorticoid in a patient with chronic obstructive pulmonary disease]. 61
25872602 2015
11
Aspirin allergy in patients with myocardial infarction: the allergist's role. 61
24468245 2014
12
Aspirin allergy desensitization in cerebrovascular disease. A report of two cases, literature review and management guide for the neurointerventionalist. 61
24556294 2014
13
The utility of using fiberoptic rhinoscopy in the diagnosis of nasal polyps. 61
24274928 2013
14
Peripheral T-cell lymphoma mimicking 5-aminosalicylate hypersensitivity in ulcerative colitis. 61
24134170 2013
15
Cardiovascular prophylaxis and aspirin "allergy". 61
23639713 2013
16
A case of type I variant Kounis syndrome with Samter-Beer triad. 61
23675559 2013
17
Aspirin desensitization in patients undergoing percutaneous coronary intervention: a survey of current practice. 61
23558870 2013
18
Primary PCI with endothelial progenitor cell-capture stent in patient with skull base fracture and aspirin allergy. 61
23575723 2013
19
Safety of aspirin desensitization in patients with reported aspirin allergy and cardiovascular disease. 61
22990948 2013
20
Rapid desensitisation of patients with aspirin allergy who undergo coronary angioplasty. 61
21933761 2011
21
Willow species and aspirin: different mechanism of actions. 61
21226125 2011
22
The Kounis-Zavras syndrome with the Samter-Beer triad. 61
21566756 2011
23
A novel drug-eluting stent using bioabsorbable polymer technology: two-year follow-up of the CURAMI registry. 61
17942172 2009
24
Safety and tolerability of 600 mg clopidogrel bolus in patients with acute ischemic stroke: preliminary experience. 61
18830204 2008
25
[The relationship between smoking and nasal polyposis]. 61
19052488 2008
26
[Epidemiological characteristics, distribution of allergens, and symptom severity in patients with perennial allergic rhinitis, living in Konya region]. 61
19052490 2008
27
The primary and secondary prevention of coronary artery disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). 61
18574278 2008
28
Rapid oral aspirin desensitization for patients with aspirin allergy requiring dual antiplatelet therapy. 61
18306836 2008
29
An economic analysis of aspirin desensitization in aspirin-exacerbated respiratory disease. 61
17716716 2008
30
Rapid desensitization protocols for patients with cardiovascular disease and aspirin hypersensitivity in an era of dual antiplatelet therapy. 61
17200429 2007
31
The rate of checking urine microalbumin and aspirin primary prevention in type 2 DM. 61
16756047 2006
32
Worsening of asthma with systemic corticosteroids. A case report and review of literature. 61
16606375 2006
33
Underutilization of aspirin in hemodialysis patients for primary and secondary prevention of cardiovascular disease. 61
16312265 2005
34
Evaluation of presence of aspirin-related warnings with willow bark. 61
15928264 2005
35
Clinical usefulness of cellular antigen stimulation test in detection of aspirin allergy. 61
16324421 2005
36
Aspirin sensitivity: implications for patients with coronary artery disease. 61
15613671 2004
37
Antithrombotic therapy for coronary artery disease: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. 61
15383483 2004
38
Thwarting an aspirin allergy. Aspirin can trigger allergy and asthma symptoms. Careful desensitization can hold them at bay. 61
15381494 2004
39
Aspirin "allergy" and resistance. 61
15312890 2004
40
Approach to "aspirin allergy" in cardiovascular patients. 61
15238467 2004
41
Antiplatelet agents for the prevention of cardiovascular disease in diabetes mellitus. 61
15049721 2004
42
The platelet in diabetes: focus on prevention of ischemic events. 61
12832332 2003
43
Anaphylactic reaction to a dietary supplement containing willow bark. 61
12773073 2003
44
Antiplatelet therapy from clinical trials to clinical practice. 61
15931295 2003
45
Prophylaxis of the antiphospholipid syndrome: a consensus report. 61
12892387 2003
46
Treatment for the procoagulant state in type 2 diabetes. 61
11727398 2001
47
New recommendations from the 1999 American College of Cardiology/American Heart Association acute myocardial infarction guidelines. 61
11346067 2001
48
[Aspirin: allergy or intolerance]. 61
10763208 2000
49
COX-2 inhibitors and dental pain control. 61
10825891 1999
50
Transient dilatation of the abdominal aorta in an infant with Kawasaki disease associated with thrombocytopenia. 61
7572158 1995

Variations for Aspirin Allergy

Expression for Aspirin Allergy

Search GEO for disease gene expression data for Aspirin Allergy.

Pathways for Aspirin Allergy

Pathways related to Aspirin Allergy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.23 PTGS1 P2RY12 ITGA2B
2 10.84 TPO ITGA2B
3 10.51 PTGS1 P2RY12 ITGA2B

GO Terms for Aspirin Allergy

Biological processes related to Aspirin Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 8.96 TGM2 P2RY12
2 platelet aggregation GO:0070527 8.62 P2RY12 ITGA2B

Molecular functions related to Aspirin Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 8.62 TPO PTGS1

Sources for Aspirin Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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