Aspirin Resistance disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ASP030 MIFTS: 47	Aspirin Resistance Categories: Blood diseases, Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Aspirin Resistance

MalaCards integrated aliases for Aspirin Resistance:

Name: Aspirin Resistance ⁵⁷

Aspirin, Resistance to Cardioprotective Effect of ⁵⁷

Aspirin, Resistance to Antithrombotic Effect of ⁵⁷

Aspirin Cardioprotective Effect of ⁵⁷

Aspirin Antithrombotic Effect of ⁵⁷

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Blood diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁷ 608223

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Summaries for Aspirin Resistance

OMIM : ⁵⁷ Aspirin (acetylsalicylic acid) is a classic nonsteroidal antiinflammatory agent that irreversibly inhibits type I cyclooxygenase (PTGS1, or COX1; 176805) in platelets, resulting in decreased production of thromboxane A2 (TXA2) and inhibition of platelet aggregation. Because of this feature, it is used therapeutically to prevent cardiothrombotic events. Individuals show a variable response to the drug, referred to as aspirin ineffectiveness or resistance, in which not all individuals or populations appear to receive the full prophylactic or therapeutic benefits (summary by Zhou et al., 2011). Halushka and Halushka (2002) discussed a possible basis for resistance to the cardioprotective effect of aspirin. (608223)

MalaCards based summary : Aspirin Resistance, also known as aspirin, resistance to cardioprotective effect of, is related to vascular disease and myocardial infarction. An important gene associated with Aspirin Resistance is PTGS1 (Prostaglandin-Endoperoxide Synthase 1), and among its related pathways/superpathways are Focal Adhesion and Pathways in cancer. The drugs Aspirin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and kidney, and related phenotypes are cellular and cardiovascular system

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Related Diseases for Aspirin Resistance

Diseases related to Aspirin Resistance via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)

#	Related Disease	Score	Top Affiliating Genes
1	vascular disease	29.6	APOB HMOX1 ITGB3
2	myocardial infarction	29.3	APOB ITGA2 ITGB3 PTGS1 PTGS2
3	arteries, anomalies of	10.4
4	coronary artery anomaly	10.4
5	heart disease	10.2
6	ischemia	10.1
7	active peptic ulcer disease	10.1	PTGS1 PTGS2
8	morphine dependence	10.1	PTGS1 PTGS2
9	hydrops, lactic acidosis, and sideroblastic anemia	10.1	PTGS1 PTGS2
10	antenatal bartter syndrome	10.0	PTGS1 PTGS2
11	clopidogrel resistance	10.0	ITGB3 PTGS2
12	diabetes mellitus	10.0
13	gastric ulcer	10.0	PTGS1 PTGS2
14	dyspepsia	10.0	PTGS1 PTGS2
15	fetal and neonatal alloimmune thrombocytopenia	10.0	ITGA2 ITGB3
16	thrombocytopenia due to platelet alloimmunization	10.0	ITGA2 ITGB3
17	primary thrombocytopenia	10.0	ITGA2 ITGB3
18	stomach disease	10.0	PTGS1 PTGS2
19	autoimmune disease of blood	10.0	ITGA2 ITGB3
20	angioedema	10.0	PTGS1 PTGS2
21	von willebrand disease, type 2	10.0	ITGA2 ITGB3
22	coronary heart disease 1	10.0
23	thrombosis	10.0
24	cerebrovascular disease	10.0
25	gastroesophageal reflux	10.0	PTGS1 PTGS2
26	thrombasthenia	10.0	ITGA2 ITGB3
27	urticaria	10.0	PTGS1 PTGS2
28	glanzmann thrombasthenia	10.0	ITGA2 ITGB3
29	gas gangrene	9.9
30	proteasome-associated autoinflammatory syndrome 1	9.9	PTGS1 PTGS2
31	bernard-soulier syndrome	9.9	ITGA2 ITGB3
32	diabetes mellitus, noninsulin-dependent	9.8
33	peripheral vascular disease	9.8
34	acute myocardial infarction	9.8
35	diabetic angiopathy	9.8
36	rheumatic disease	9.8	PTGS1 PTGS2
37	systemic lupus erythematosus	9.7
38	angina pectoris	9.7
39	congestive heart failure	9.7
40	ischemic heart disease	9.7
41	single ventricular heart	9.7
42	thalassemia	9.7
43	peripheral artery disease	9.7
44	pre-eclampsia	9.7
45	nephrotic syndrome	9.7
46	carotid stenosis	9.7
47	eclampsia	9.7
48	lupus erythematosus	9.7

Graphical network of the top 20 diseases related to Aspirin Resistance:

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Symptoms & Phenotypes for Aspirin Resistance

Clinical features from OMIM:

608223

MGI Mouse Phenotypes related to Aspirin Resistance:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	9.91	APOB HMOX1 ITGA2 ITGB3 PTGS1 PTGS2
2	cardiovascular system	MP:0005385	9.85	APOB HMOX1 ITGB3 PTGS1 PTGS2
3	homeostasis/metabolism	MP:0005376	9.85	APOB HMOX1 ITGA2 ITGB3 PTGS1 PTGS2
4	hematopoietic system	MP:0005397	9.8	HMOX1 ITGA2 ITGB3 PTGS1 PTGS2
5	muscle	MP:0005369	9.65	APOB HMOX1 ITGB3 PTGS1 PTGS2
6	liver/biliary system	MP:0005370	9.62	APOB HMOX1 ITGB3 PTGS2
7	renal/urinary system	MP:0005367	9.46	HMOX1 ITGB3 PTGS1 PTGS2
8	reproductive system	MP:0005389	9.35	APOB HMOX1 ITGB3 PTGS1 PTGS2
9	respiratory system	MP:0005388	8.92	HMOX1 ITGB3 PTGS1 PTGS2

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Drugs & Therapeutics for Aspirin Resistance

Drugs for Aspirin Resistance (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Aspirin

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

50-78-2

2244

Clopidogrel

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

113665-84-2, 120202-66-6

60606

Ticlopidine

Approved

Phase 4,Phase 3,Phase 2

55142-85-3

5472

Cilostazol

Approved, Investigational

Phase 4

73963-72-1

2754

Racepinephrine

Approved

Phase 4

329-65-7

838

Epinephrine

Approved, Vet_approved

Phase 4

51-43-4

5816

Dipyridamole

Approved

Phase 4

58-32-2

3108

Bivalirudin

Approved, Investigational

Phase 4

128270-60-0

16129704

Tirofiban

Approved

Phase 4,Phase 2

144494-65-5

60947

Heparin

Approved, Investigational

Phase 4

9005-49-6

772 46507594

Nitroglycerin

Approved, Investigational

Phase 4

55-63-0

4510

Pravastatin

Approved

Phase 4

81093-37-0

54687

arachidonic acid

Experimental

Phase 4

506-32-1

444899

Acetylsalicylic acid lysinate

Phase 4

lysine

Phase 4

Antipyretics

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Peripheral Nervous System Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Anti-Inflammatory Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Analgesics

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Fibrinolytic Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Analgesics, Non-Narcotic

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Anti-Inflammatory Agents, Non-Steroidal

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Antirheumatic Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Cyclooxygenase Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Platelet Aggregation Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Vasodilator Agents

Phase 4

Purinergic P2Y Receptor Antagonists

Phase 4,Phase 3,Phase 2,Not Applicable

Purinergic P2 Receptor Antagonists

Phase 4,Phase 3,Phase 2,Not Applicable

Neurotransmitter Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Cytochrome P-450 Enzyme Inhibitors

Phase 4,Phase 3,Phase 2

Cytochrome P-450 CYP2C19 Inhibitors

Phase 4,Phase 3,Phase 2

Autonomic Agents

Phase 4

Bronchodilator Agents

Phase 4

Phosphodiesterase 3 Inhibitors

Phase 4

Phosphodiesterase Inhibitors

Phase 4

Respiratory System Agents

Phase 4

Protective Agents

Phase 4,Phase 2

Anti-Asthmatic Agents

Phase 4

Neuroprotective Agents

Phase 4

Epinephryl borate

Phase 4

Aspirin, Dipyridamole Drug Combination

Phase 4

Interferon Inducers

Phase 4,Phase 2

calcium heparin

Phase 4

Adjuvants, Immunologic

Phase 4,Phase 2

Antiviral Agents

Phase 4,Phase 2

Antibiotics, Antitubercular

Phase 4,Phase 2

Anti-Bacterial Agents

Phase 4,Phase 2

Radiation-Protective Agents

Phase 4,Phase 2

Anti-Infective Agents

Phase 4,Phase 2

Immunologic Factors

Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 53)

#	Name	Status	NCT ID	Phase	Drugs
1	Aspirin Resistance Reversibility in Diabetic Patients	Unknown status	NCT01935193	Phase 4	lysine acetylsalicylate
2	Antiaggregation in Primary Prevention of Vascular Access for Hemodialysis	Unknown status	NCT02055131	Phase 4	aspirin
3	Type 2 Diabetes Mellitus and Atherosclerosis	Unknown status	NCT01250340	Phase 4	Aspirin;Placebo
4	Overcome Biochemical Aspirin Resistance Through Cilostazol Combination	Completed	NCT00446641	Phase 4	Cilostazol;placebo
5	Dual Antiplatelet Therapy in Patients With Aspirin Resistance Following Coronary Artery Bypass Grafting	Completed	NCT01159639	Phase 4	Clopidogrel
6	Aspirin in the Prevention of Cardiovascular Events in Hemodialysis Patients	Withdrawn	NCT01198379	Phase 4	aspirin;Placebo
7	Platelet Hyperreactivity to Aspirin and Stroke	Completed	NCT00766896	Phase 4	Aspirin (platelet sensitive versus platelet hyperreactivity)
8	Aspirin Responsiveness in Women at Risk for Cardiac Events	Completed	NCT00818337	Phase 4	Aspirin
9	Modified-release Dipyridamole/Aspirin (200mg/25mg bd) Versus Aspirin (75mg) in Aspirin-resistant Patients	Completed	NCT00129038	Phase 4	modified-release dipyridamole/aspirin;aspirin
10	The Effect of Two Aspirin Dosing Strategies for Obese Women at High Risk for Preeclampsia	Not yet recruiting	NCT03735433	Phase 4	162mg aspirin dose
11	Study of Tirofiban Administration in Patients With Aspirin and or Clopidogrel Resistance	Completed	NCT00398463	Phase 4	Tirofiban;Placebo
12	Resistance to Aspirin and/or Clopidogrel Among Patients With PAD.	Completed	NCT00262561	Phase 4	Aspirin
13	Clinical Management of Antiplatelet Drug Resistance in Patients With Drug Eluting Coronary Stents	Withdrawn	NCT00589862	Phase 4	Plavix (Clopidogrel)
14	Trial to Assess the Efficacy of Combination Formula of Aspirin Plus Clopidogrel in Patients With Coronary Stent	Completed	NCT02410083	Phase 4	Clopirin 1;Clopidogrel-Aspirin(co-administration) 1;Clopirin 2;Clopidogrel-Aspirin(co-administration) 2
15	Aspirin Non-responsiveness and Clopidogrel Endpoint Trial.	Completed	NCT00222261	Phase 4	aspirin;clopidogrel
16	Studies of Traditional Chinese Medicine Clinical Efficacy Evaluation Index	Completed	NCT01502943	Phase 4	Louxiangdan Tongxin granules;TCM granules placebo;Chixiangshen Tongxin granules;TCM granule placebo plus western basis treatment;Western basis treatment
17	Thromboelastography As An Assessment Tool for Possible Clopidogrel and Aspirin Resistance	Unknown status	NCT00697021	Phase 3	Aspirin (200mg) and/or Plavix (150mg) dosage according to TEG;Aspirin 100mg and Plavix 75mg
18	ThrombElastoGraphic Haemostatic Status and Antiplatelet Therapy After Coronary Artery Bypass Graft Surgery	Unknown status	NCT01046942	Phase 3	Clopidogrel+acetylsalicylic acid;acetylsalicylic acid
19	Aspirin Resistance and Stroke Risk: Platelet Function Analysis in Patients With Ischemic Events	Completed	NCT01586975	Phase 2, Phase 3	Clopidogrel;Aspirin 81 mg;Aspirin >300 mg
20	The Effects of Omega-3 Fatty Acids on Aspirin Resistance	Completed	NCT00771914	Phase 1, Phase 2	Aspirin;Lovaza;Both Aspirin and Lovaza
21	Aspirin Resistance and Percutaneous Coronary Intervention (PCI)	Completed	NCT01103440	Phase 2	Intravenous Glycoprotein inhibitor + ASA, Clopidogrel;Antiplatelet Therapy (ASA, Clopidogrel)
22	Fish Oil and Aspirin With Type 2 Diabetes	Completed	NCT01181882	Phase 2
23	Effect of Low Dose Aspirin on Birthweight in Twins: The GAP Trial.	Completed	NCT02280031	Phase 2	Acetylsalicylic Acid;Placebo
24	In-Vivo Bleeding Volume Test for Platelet-Aspirin Interaction	Unknown status	NCT01047722	Phase 1	Aspirin ingestion followed by doing a Bleeding Volume Test
25	Mechanism Based Resistance to Aspirin	Completed	NCT00948987	Phase 1	Aspirin
26	Aspirin Resistance in Systemic Lupus Erythematosus (SLE)	Completed	NCT00731302	Phase 1	aspirin and meloxicam
27	Investigation of Platelet Function and Aspirin Resistance in Chronic Dialysis Patient	Unknown status	NCT01045785
28	Prevalence and Level of Thienopyridine Resistance Seen in a Contemporary Percutaneous Coronary Intervention or Coronary Artery Bypass Graft Population	Unknown status	NCT01408927
29	Platelet Reactivity and MES During CEA	Unknown status	NCT01547039
30	Relationship Between Level of Hemoglobin A1c and Platelet Function in Patients Undergoing Cardiac Surgery	Unknown status	NCT02711124
31	Prevalence and Profile of Aspirin Resistance in Hemodialysis Patients	Completed	NCT00792272
32	Aspirin Resistance and Prognosis of Patients With Critical Limb Ischaemia	Completed	NCT01104441
33	Prevalence of Aspirin Resistance in Chronic Kidney Disease Patients	Completed	NCT01364779
34	The Effect of Serum LDL Lowering on Aspirin Resistance	Completed	NCT00466154	Not Applicable	Aspirin
35	Danish Aspirin Resistance Trial - Pilot Study	Completed	NCT00389129	Not Applicable	acetylsalicylic acid
36	Aspirin Resistance in Coronary Artery Disease	Completed	NCT00753935	Early Phase 1	enteric-coated aspirin;Chewable aspirin
37	Aspirin Resistance in Women With Migraine	Withdrawn	NCT01257893	Not Applicable	Aspirin (acetylsalicylic acid);Placebo
38	Laboratory Aspirin Resistance in Diabetics and Non-Diabetics	Completed	NCT00563875	Not Applicable	acetylsalicylic acid
39	The Study on Profile and Genetic Factors of Aspirin Resistance (ProGEAR Study)	Completed	NCT00250380
40	Enteric Coating as a Factor in Aspirin Resistance	Completed	NCT00531362		Plain aspirin
41	Aspirin Resistance and Sleep Apnea in Type-2 Diabetic Patients	Terminated	NCT01788930	Not Applicable
42	Effect of Glucose Control on the Response to Aspirin in Type 2 Diabetic Patients	Completed	NCT00649909
43	The Efficacy of Aspirin in the Postoperative Period in Vascular Surgery	Completed	NCT01432652
44	Aspirin Resistance Following Coronary Bypass Surgery	Terminated	NCT00260377	Not Applicable
45	Genotypic and Phenotypic Correlates of Resistance to Aspirin	Completed	NCT01361620	Not Applicable	aspirin
46	Measurement of Platelet Dense Granule Release in Healthy Volunteers	Withdrawn	NCT00942617	Not Applicable	Aspirin
47	Aspirin Responsiveness and Outcome in Coronary Artery Bypass Graft (CABG) Surgery	Completed	NCT01174862
48	Optimum Platelet Inhibition After Coronary Bypass Surgery	Completed	NCT00262275	Not Applicable	Aspirin, Clopidogrel
49	Aspirin Responsiveness in Women With Coronary Artery Disease	Completed	NCT01406990
50	Platelet Reactivity In Patients With Nuisance Bleeding On A Thienopyridine	Completed	NCT01152229

Search NIH Clinical Center for Aspirin Resistance

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Genetic Tests for Aspirin Resistance

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Anatomical Context for Aspirin Resistance

MalaCards organs/tissues related to Aspirin Resistance:

⁴¹

Testes, Heart, Kidney, Endothelial, Whole Blood

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Publications for Aspirin Resistance

Articles related to Aspirin Resistance:

(show top 50) (show all 399)

#	Title	Authors	Year
1	Aspirin Resistance: Risk Factors and Prognostic Significance in Patients with Cerebral Small Vessel Disease. ( 29530996 )	Staszewski J....StA9pieA8 A.	2018
2	The Relationship Between Aspirin Resistance and Carotid Imaging in Young Patients With ST-Segment Elevated Myocardial Infarction: A Cross-Sectional Study. ( 29888621 )	Somuncu M.U....Karakurt S.T.	2018
3	Aspirin Resistance: Cardiovascular Risk Game Changer. ( 29757761 )	Yassin A.S....Pahuja M.	2018
4	Effects of Ramadan fasting on aspirin resistance in type 2 diabetic patients. ( 29529091 )		2018
5	Associations Between PFA-Measured Aspirin Resistance, Platelet Count, Renal Function, and Angiotensin Receptor Blockers. ( 29996660 )	Chen HY...Chou P	2018
6	Aspirin resistance predicts unfavorable functional outcome in acute ischemic stroke patients. ( 30016728 )	Wang CW...Ji SB	2018
7	Effects of aspirin resistance and mean platelet volume on vascular access failure in hemodialysis patients. ( 30025441 )	Cho A...Noh JW	2018
8	Investigation into the causes of aspirin resistance in healthy dogs. ( 30302763 )	Haines JM...Court MH	2018
9	Prevalence of aspirin resistance by thromboelastography plus platelet mapping in children with CHD: a single-centre experience. ( 30501653 )	Berganza FM...Brownlee J	2018
10	Aspirin resistance in the early postoperative period: Pharmacokinetics may be part of the answer. ( 30538026 )	Gutsche JT...Augoustides JG	2018
11	Global Trends in Aspirin Resistance-Related Research from 1990 to 2015: A Bibliometric Analysis. ( 28667787 )	Al-Jabi S.W.	2017
12	Genetic signatures in ischemic stroke: Focus on aspirin resistance. ( 28969559 )	Munshi A....Singh S.	2017
13	Suspected aspirin resistance in individual healthy adult warmblood horses. ( 28390056 )	Roscher K.A....Moritz A.	2017
14	My Approach to the patient with CAD and aspirin resistance. ( 28865598 )	Bhatt D.L.	2017
15	Aspirin resistance are associated with long-term recurrent stroke events after ischaemic stroke. ( 28842303 )	Zhang N....Zhou L.	2017
16	Interaction among COX-2, P2Y1 and GPIIIa gene variants is associated with aspirin resistance and early neurological deterioration in Chinese stroke patients. ( 28068952 )	Yi X....Lin J.	2017
17	Association of GPIa and COX-2 gene polymorphism with aspirin resistance. ( 28948649 )	Wang H....Fang Q.	2017
18	Targeting aspirin resistance with nutraceuticals: a possible strategy for reducing cardiovascular morbidity and mortality. ( 28912955 )	DiNicolantonio J.J....McCarty M.F.	2017
19	The incidence of aspirin resistance in heart transplantation recipients. ( 28747943 )	Urbanowicz T....Jemielity M.	2017
20	Over-expression of cyclooxygenase-2 in increased reticulated platelets leads to aspirin resistance after elective off-pump coronary artery bypass surgery. ( 29149707 )	Gong X....Li C.	2017
21	Decreased turnover aspirin resistance by bidaily aspirin intake and efficient cytoreduction in myeloproliferative neoplasms. ( 29090588 )	Perrier-Cornet A....Galinat H.	2017
22	Post-pregnancy aspirin resistance appears not to be related with recurrent hypertensive disorders of pregnancy. ( 28033561 )	Abheiden C.N.H....de Vries J.I.P.	2017
23	rs5911 and rs3842788 Genetic Polymorphism, Blood Stasis Syndrome, and Plasma TXB2 and hs-CRP Levels Are Associated with Aspirin Resistance in Chinese Chronic Stable Angina Patients. ( 28465708 )	Xue M....Zhao Q.	2017
24	Prevalence of aspirin resistance in patients with type II diabetes: a descriptive-analytical studya8c. ( 28025961 )		2017
25	Biochemical aspirin resistance is associated with increased stroke severity and infarct volumes in ischemic stroke patients. ( 29100372 )		2017
26	Platelet Carbonic Anhydrase II, a Forgotten Enzyme, May Be Responsible for Aspirin Resistance. ( 29090039 )		2017
27	PFA-100-measured aspirin resistance is the predominant risk factor for hospitalized cardiovascular events in aspirin-treated patients: A 5-year cohort study. ( 29055181 )		2017
28	Aspirin resistance in coronary heart disease: Current understandings and strategies. ( 28191510 )	Han Y.L.	2016
29	The effectiveness of antioxidant therapy in aspirin resistance, diabetes population for prevention of thrombosis. ( 27393925 )	Aboonabi A....Singh I.	2016
30	Aspirin Resistance Predicts Adverse Cardiovascular Events in Patients with Symptomatic Peripheral Artery Disease. ( 28100965 )	Pasala T....Gandhi S.	2016
31	Aspirin resistance in cerebrovascular disease and the role of glycoprotein IIIa polymorphism in Turkish stroke patients. ( 26809135 )	Derle E....Can U.	2016
32	Interaction between COX-1 and COX-2 Variants Associated with Aspirin Resistance in Chinese Stroke Patients. ( 27318652 )		2016
33	Prevalence of aspirin resistance in Asian-Indian patients with stable coronary artery disease. ( 24482126 )	Chadha DS...Arun SS	2016
34	A brief review on the mechanisms of aspirin resistance. ( 27372038 )	Du G...Wang J	2016
35	A study into the genetic basis of aspirin resistance in Pakistani patients with coronary artery disease. ( 27393450 )	Mukarram O...Mohyuddin A	2016
36	High prevalence of aspirin resistance in elderly patients with cardiovascular disease and metabolic syndrome. ( 27582771 )	Liu L...Li JH	2016
37	Establishing a predictive model for aspirin resistance in elderly Chinese patients with chronic cardiovascular disease. ( 27594876 )	Cao J...Fan L	2016
38	Aspirin resistance and other aspirin-related concerns. ( 26573589 )	Cai G...Fu Y	2016
39	The Interplay between Stroke Severity, Antiplatelet Use, and Aspirin Resistance in Ischemic Stroke. ( 26576697 )	Agayeva N...Arsava EM	2016
40	Does high serum uric acid level cause aspirin resistance? ( 26656902 )	Yildiz BS...Evrengul H	2016
41	Low dose aspirin and pregnancy: how important is aspirin resistance? ( 26929162 )	Navaratnam K...Alfirevic Z	2016
42	Investigating the role of aspirin resistance in obstetrics may optimise prevention of pre-eclampsia. ( 26969603 )	Hoffman MK	2016
43	The lack of aspirin resistance in patients with coronary artery disease. ( 26980433 )	Homor?di N...Muszbek L	2016
44	Aspirin resistance is associated with increased stroke severity and infarct volume. ( 27060166 )	Oh MS...Lee BC	2016
45	Multiple Electrode Aggregometry is an adequate method for aspirin response testing in myeloproliferative neoplasms and differentiates the mechanisms of aspirin resistance. ( 27105311 )	Gillet B...Galinat H	2016
46	Chinese Herbal Medicine for Aspirin Resistance: A Systematic Review and Meta-Analysis. ( 27153119 )	Chen H...Chen X	2016
47	Aspirin resistance may be identified by miR-92a in plasma combined with platelet distribution width. ( 27208561 )	Binderup HG...Brasen CL	2016
48	Aspirin Resistance in Different Doses by Bleeding Time and Urinary 11-dehydro-thromboxane B2. ( 29953191 )	Maleki A...Ahmadvand H	2016
49	Aspirin resistance in patients undergoing hemodialysis and effect of hemodialysis on aspirin resistance. ( 23698727 )	Aksu HU...Uslu N	2015
50	Impact of aspirin resistance on outcomes among patients following coronary artery bypass grafting: exploratory analysis from randomized controlled trial (NCT01159639). ( 25095738 )	Petricevic M...Biocina B	2015

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Genes for Aspirin Resistance

Genes related to Aspirin Resistance (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PTGS1	Prostaglandin-Endoperoxide Synthase 1	Protein Coding	17.87	GeneCards inferred via : Publications (show sections)
2	ITGB3	Integrin Subunit Beta 3	Protein Coding	17.37	GeneCards inferred via : Publications (show sections)
3	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	17.3	GeneCards inferred via : Publications (show sections)
4	ITGA2	Integrin Subunit Alpha 2	Protein Coding	16.75	GeneCards inferred via : Publications (show sections)
5	APOB	Apolipoprotein B	Protein Coding	16.75	GeneCards inferred via : Publications (show sections)
6	HMOX1	Heme Oxygenase 1	Protein Coding	16.4	GeneCards inferred via : Publications (show sections)

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Variations for Aspirin Resistance

Sources

Expression for Aspirin Resistance

Search GEO for disease gene expression data for Aspirin Resistance.

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Pathways for Aspirin Resistance

Pathways related to Aspirin Resistance according to GeneCards Suite gene sharing:

(show all 25)

#	Super pathways	Score	Top Affiliating Genes
1	Focal Adhesion ¹ ³⁷ Show member pathways HGF Pathway ⁶⁴ Integrin-mediated Cell Adhesion ¹	12.57	ITGA2 ITGB3 PTGS2
2	Pathways in cancer ³⁷	12.5	HMOX1 ITGA2 PTGS2
3	NF-kappaB Signaling ⁴	12.24	HMOX1 PTGS1 PTGS2
4	MicroRNAs in cancer ³⁷	12.18	HMOX1 ITGB3 PTGS2
5	Development VEGF signaling via VEGFR2 - generic cascades ²² Show member pathways Development VEGF signaling and activation ²² VEGF - VEGF R2 Signaling Pathways ⁶⁵	12.04	ITGB3 PTGS1 PTGS2
6	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁶ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	11.88	APOB PTGS1 PTGS2
7	Hematopoietic cell lineage ³⁷	11.6	ITGA2 ITGB3
8	Small cell lung cancer ³⁷	11.58	ITGA2 PTGS2
9	Phagocytosis of Microbes ⁶⁴	11.53	ITGA2 ITGB3
10	Platelet activation ³⁷	11.52	ITGA2 ITGB3 PTGS1
11	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁵	11.44	ITGB3 PTGS2
12	Non-integrin membrane-ECM interactions ⁶⁶ Show member pathways Syndecan interactions ⁶⁶	11.41	ITGA2 ITGB3
13	Celecoxib Pathway, Pharmacodynamics ⁶¹	11.34	PTGS1 PTGS2
14	ECM proteoglycans ⁶⁶	11.32	ITGA2 ITGB3
15	Regulation of lipolysis in adipocytes ³⁷	11.29	PTGS1 PTGS2
16	Angiogenesis (CST) ⁴	11.28	HMOX1 ITGB3 PTGS2
17	Cell adhesion_Endothelial cell contacts by non-junctional mechanisms ²²	11.14	ITGA2 ITGB3
18	Prostaglandin Synthesis and Regulation ¹	10.99	PTGS1 PTGS2
19	Ibuprofen Pathway, Pharmacodynamics ⁶¹	10.94	PTGS1 PTGS2
20	HETE and HPETE biosynthesis and metabolism ²² Show member pathways lipoxin biosynthesis ¹ resolvin D biosynthesis ¹ Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ⁶⁶	10.89	PTGS1 PTGS2
21	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics ⁶¹	10.84	ITGA2 ITGB3 PTGS1
22	Eicosanoid Synthesis ¹	10.81	PTGS1 PTGS2
23	Prostaglandin 2 biosynthesis and metabolism FM ²²	10.77	PTGS1 PTGS2
24	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹	10.5	PTGS1 PTGS2
25	Overview of nanoparticle effects ¹	10.08	HMOX1 PTGS1 PTGS2

Sources

GO Terms for Aspirin Resistance

Cellular components related to Aspirin Resistance according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endoplasmic reticulum	GO:0005783	9.62	APOB HMOX1 PTGS1 PTGS2
2	endoplasmic reticulum membrane	GO:0005789	9.46	APOB HMOX1 PTGS1 PTGS2
3	caveola	GO:0005901	9.26	HMOX1 PTGS2
4	integrin complex	GO:0008305	8.96	ITGA2 ITGB3
5	intracellular membrane-bounded organelle	GO:0043231	8.92	APOB HMOX1 PTGS1 PTGS2

Biological processes related to Aspirin Resistance according to GeneCards Suite gene sharing:

(show all 22)

#	Name	GO ID	Score	Top Affiliating Genes
1	lipid metabolic process	GO:0006629	9.74	APOB PTGS1 PTGS2
2	wound healing	GO:0042060	9.61	ITGA2 ITGB3
3	cell-matrix adhesion	GO:0007160	9.6	ITGA2 ITGB3
4	integrin-mediated signaling pathway	GO:0007229	9.59	ITGA2 ITGB3
5	response to organic substance	GO:0010033	9.58	APOB PTGS2
6	viral entry into host cell	GO:0046718	9.58	ITGA2 ITGB3
7	cellular oxidant detoxification	GO:0098869	9.56	PTGS1 PTGS2
8	cellular response to mechanical stimulus	GO:0071260	9.55	ITGA2 PTGS2
9	fatty acid biosynthetic process	GO:0006633	9.54	PTGS1 PTGS2
10	cellular response to heat	GO:0034605	9.52	HMOX1 PTGS2
11	positive regulation of cell migration involved in sprouting angiogenesis	GO:0090050	9.51	HMOX1 PTGS2
12	low-density lipoprotein particle clearance	GO:0034383	9.49	APOB HMOX1
13	cell adhesion mediated by integrin	GO:0033627	9.48	ITGA2 ITGB3
14	prostaglandin metabolic process	GO:0006693	9.46	PTGS1 PTGS2
15	positive regulation of smooth muscle contraction	GO:0045987	9.43	ITGA2 PTGS2
16	cell-substrate adhesion	GO:0031589	9.4	ITGA2 ITGB3
17	prostaglandin biosynthetic process	GO:0001516	9.37	PTGS1 PTGS2
18	response to oxidative stress	GO:0006979	9.33	HMOX1 PTGS1 PTGS2
19	mesodermal cell differentiation	GO:0048333	9.32	ITGA2 ITGB3
20	cyclooxygenase pathway	GO:0019371	9.26	PTGS1 PTGS2
21	regulation of blood pressure	GO:0008217	9.13	HMOX1 PTGS1 PTGS2
22	positive regulation of smooth muscle cell proliferation	GO:0048661	8.8	HMOX1 ITGA2 PTGS2

Molecular functions related to Aspirin Resistance according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	enzyme binding	GO:0019899	9.43	HMOX1 ITGB3 PTGS2
2	dioxygenase activity	GO:0051213	9.37	PTGS1 PTGS2
3	virus receptor activity	GO:0001618	9.32	ITGA2 ITGB3
4	peroxidase activity	GO:0004601	9.16	PTGS1 PTGS2
5	heme binding	GO:0020037	9.13	HMOX1 PTGS1 PTGS2
6	prostaglandin-endoperoxide synthase activity	GO:0004666	8.62	PTGS1 PTGS2

Sources

Sources for Aspirin Resistance

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia