MCID: ASP030
MIFTS: 47

Aspirin Resistance

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Aspirin Resistance

MalaCards integrated aliases for Aspirin Resistance:

Name: Aspirin Resistance 57
Aspirin, Resistance to Cardioprotective Effect of 57
Aspirin, Resistance to Antithrombotic Effect of 57
Aspirin Cardioprotective Effect of 57
Aspirin Antithrombotic Effect of 57

Classifications:



External Ids:

OMIM 57 608223

Summaries for Aspirin Resistance

OMIM : 57 Aspirin (acetylsalicylic acid) is a classic nonsteroidal antiinflammatory agent that irreversibly inhibits type I cyclooxygenase (PTGS1, or COX1; 176805) in platelets, resulting in decreased production of thromboxane A2 (TXA2) and inhibition of platelet aggregation. Because of this feature, it is used therapeutically to prevent cardiothrombotic events. Individuals show a variable response to the drug, referred to as aspirin ineffectiveness or resistance, in which not all individuals or populations appear to receive the full prophylactic or therapeutic benefits (summary by Zhou et al., 2011). Halushka and Halushka (2002) discussed a possible basis for resistance to the cardioprotective effect of aspirin. (608223)

MalaCards based summary : Aspirin Resistance, also known as aspirin, resistance to cardioprotective effect of, is related to vascular disease and myocardial infarction. An important gene associated with Aspirin Resistance is PTGS1 (Prostaglandin-Endoperoxide Synthase 1), and among its related pathways/superpathways are Focal Adhesion and Pathways in cancer. The drugs Aspirin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and kidney, and related phenotypes are cellular and cardiovascular system

Related Diseases for Aspirin Resistance

Diseases related to Aspirin Resistance via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 vascular disease 29.6 APOB HMOX1 ITGB3
2 myocardial infarction 29.3 APOB ITGA2 ITGB3 PTGS1 PTGS2
3 arteries, anomalies of 10.4
4 coronary artery anomaly 10.4
5 heart disease 10.2
6 ischemia 10.1
7 active peptic ulcer disease 10.1 PTGS1 PTGS2
8 morphine dependence 10.1 PTGS1 PTGS2
9 hydrops, lactic acidosis, and sideroblastic anemia 10.1 PTGS1 PTGS2
10 antenatal bartter syndrome 10.0 PTGS1 PTGS2
11 clopidogrel resistance 10.0 ITGB3 PTGS2
12 diabetes mellitus 10.0
13 gastric ulcer 10.0 PTGS1 PTGS2
14 dyspepsia 10.0 PTGS1 PTGS2
15 fetal and neonatal alloimmune thrombocytopenia 10.0 ITGA2 ITGB3
16 thrombocytopenia due to platelet alloimmunization 10.0 ITGA2 ITGB3
17 primary thrombocytopenia 10.0 ITGA2 ITGB3
18 stomach disease 10.0 PTGS1 PTGS2
19 autoimmune disease of blood 10.0 ITGA2 ITGB3
20 angioedema 10.0 PTGS1 PTGS2
21 von willebrand disease, type 2 10.0 ITGA2 ITGB3
22 coronary heart disease 1 10.0
23 thrombosis 10.0
24 cerebrovascular disease 10.0
25 gastroesophageal reflux 10.0 PTGS1 PTGS2
26 thrombasthenia 10.0 ITGA2 ITGB3
27 urticaria 10.0 PTGS1 PTGS2
28 glanzmann thrombasthenia 10.0 ITGA2 ITGB3
29 gas gangrene 9.9
30 proteasome-associated autoinflammatory syndrome 1 9.9 PTGS1 PTGS2
31 bernard-soulier syndrome 9.9 ITGA2 ITGB3
32 diabetes mellitus, noninsulin-dependent 9.8
33 peripheral vascular disease 9.8
34 acute myocardial infarction 9.8
35 diabetic angiopathy 9.8
36 rheumatic disease 9.8 PTGS1 PTGS2
37 systemic lupus erythematosus 9.7
38 angina pectoris 9.7
39 congestive heart failure 9.7
40 ischemic heart disease 9.7
41 single ventricular heart 9.7
42 thalassemia 9.7
43 peripheral artery disease 9.7
44 pre-eclampsia 9.7
45 nephrotic syndrome 9.7
46 carotid stenosis 9.7
47 eclampsia 9.7
48 lupus erythematosus 9.7

Graphical network of the top 20 diseases related to Aspirin Resistance:



Diseases related to Aspirin Resistance

Symptoms & Phenotypes for Aspirin Resistance

Clinical features from OMIM:

608223

MGI Mouse Phenotypes related to Aspirin Resistance:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.91 APOB HMOX1 ITGA2 ITGB3 PTGS1 PTGS2
2 cardiovascular system MP:0005385 9.85 APOB HMOX1 ITGB3 PTGS1 PTGS2
3 homeostasis/metabolism MP:0005376 9.85 APOB HMOX1 ITGA2 ITGB3 PTGS1 PTGS2
4 hematopoietic system MP:0005397 9.8 HMOX1 ITGA2 ITGB3 PTGS1 PTGS2
5 muscle MP:0005369 9.65 APOB HMOX1 ITGB3 PTGS1 PTGS2
6 liver/biliary system MP:0005370 9.62 APOB HMOX1 ITGB3 PTGS2
7 renal/urinary system MP:0005367 9.46 HMOX1 ITGB3 PTGS1 PTGS2
8 reproductive system MP:0005389 9.35 APOB HMOX1 ITGB3 PTGS1 PTGS2
9 respiratory system MP:0005388 8.92 HMOX1 ITGB3 PTGS1 PTGS2

Drugs & Therapeutics for Aspirin Resistance

Drugs for Aspirin Resistance (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-78-2 2244
2
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable 113665-84-2, 120202-66-6 60606
3
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
4
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
5
Racepinephrine Approved Phase 4 329-65-7 838
6
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
7
Dipyridamole Approved Phase 4 58-32-2 3108
8
Bivalirudin Approved, Investigational Phase 4 128270-60-0 16129704
9
Tirofiban Approved Phase 4,Phase 2 144494-65-5 60947
10
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
11
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
12
Pravastatin Approved Phase 4 81093-37-0 54687
13
arachidonic acid Experimental Phase 4 506-32-1 444899
14 Acetylsalicylic acid lysinate Phase 4
15 lysine Phase 4
16 Antipyretics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
17 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
18 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
19 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
20 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
21 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
22 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
23 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
24 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
25 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
26 Vasodilator Agents Phase 4
27 Purinergic P2Y Receptor Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
28 Purinergic P2 Receptor Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
29 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
30 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2
31 Cytochrome P-450 CYP2C19 Inhibitors Phase 4,Phase 3,Phase 2
32 Autonomic Agents Phase 4
33 Bronchodilator Agents Phase 4
34 Phosphodiesterase 3 Inhibitors Phase 4
35 Phosphodiesterase Inhibitors Phase 4
36 Respiratory System Agents Phase 4
37 Protective Agents Phase 4,Phase 2
38 Anti-Asthmatic Agents Phase 4
39 Neuroprotective Agents Phase 4
40 Epinephryl borate Phase 4
41 Aspirin, Dipyridamole Drug Combination Phase 4
42 Interferon Inducers Phase 4,Phase 2
43 calcium heparin Phase 4
44 Adjuvants, Immunologic Phase 4,Phase 2
45 Antiviral Agents Phase 4,Phase 2
46 Antibiotics, Antitubercular Phase 4,Phase 2
47 Anti-Bacterial Agents Phase 4,Phase 2
48 Radiation-Protective Agents Phase 4,Phase 2
49 Anti-Infective Agents Phase 4,Phase 2
50 Immunologic Factors Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 53)
# Name Status NCT ID Phase Drugs
1 Aspirin Resistance Reversibility in Diabetic Patients Unknown status NCT01935193 Phase 4 lysine acetylsalicylate
2 Antiaggregation in Primary Prevention of Vascular Access for Hemodialysis Unknown status NCT02055131 Phase 4 aspirin
3 Type 2 Diabetes Mellitus and Atherosclerosis Unknown status NCT01250340 Phase 4 Aspirin;Placebo
4 Overcome Biochemical Aspirin Resistance Through Cilostazol Combination Completed NCT00446641 Phase 4 Cilostazol;placebo
5 Dual Antiplatelet Therapy in Patients With Aspirin Resistance Following Coronary Artery Bypass Grafting Completed NCT01159639 Phase 4 Clopidogrel
6 Aspirin in the Prevention of Cardiovascular Events in Hemodialysis Patients Withdrawn NCT01198379 Phase 4 aspirin;Placebo
7 Platelet Hyperreactivity to Aspirin and Stroke Completed NCT00766896 Phase 4 Aspirin (platelet sensitive versus platelet hyperreactivity)
8 Aspirin Responsiveness in Women at Risk for Cardiac Events Completed NCT00818337 Phase 4 Aspirin
9 Modified-release Dipyridamole/Aspirin (200mg/25mg bd) Versus Aspirin (75mg) in Aspirin-resistant Patients Completed NCT00129038 Phase 4 modified-release dipyridamole/aspirin;aspirin
10 The Effect of Two Aspirin Dosing Strategies for Obese Women at High Risk for Preeclampsia Not yet recruiting NCT03735433 Phase 4 162mg aspirin dose
11 Study of Tirofiban Administration in Patients With Aspirin and or Clopidogrel Resistance Completed NCT00398463 Phase 4 Tirofiban;Placebo
12 Resistance to Aspirin and/or Clopidogrel Among Patients With PAD. Completed NCT00262561 Phase 4 Aspirin
13 Clinical Management of Antiplatelet Drug Resistance in Patients With Drug Eluting Coronary Stents Withdrawn NCT00589862 Phase 4 Plavix (Clopidogrel)
14 Trial to Assess the Efficacy of Combination Formula of Aspirin Plus Clopidogrel in Patients With Coronary Stent Completed NCT02410083 Phase 4 Clopirin 1;Clopidogrel-Aspirin(co-administration) 1;Clopirin 2;Clopidogrel-Aspirin(co-administration) 2
15 Aspirin Non-responsiveness and Clopidogrel Endpoint Trial. Completed NCT00222261 Phase 4 aspirin;clopidogrel
16 Studies of Traditional Chinese Medicine Clinical Efficacy Evaluation Index Completed NCT01502943 Phase 4 Louxiangdan Tongxin granules;TCM granules placebo;Chixiangshen Tongxin granules;TCM granule placebo plus western basis treatment;Western basis treatment
17 Thromboelastography As An Assessment Tool for Possible Clopidogrel and Aspirin Resistance Unknown status NCT00697021 Phase 3 Aspirin (200mg) and/or Plavix (150mg) dosage according to TEG;Aspirin 100mg and Plavix 75mg
18 ThrombElastoGraphic Haemostatic Status and Antiplatelet Therapy After Coronary Artery Bypass Graft Surgery Unknown status NCT01046942 Phase 3 Clopidogrel+acetylsalicylic acid;acetylsalicylic acid
19 Aspirin Resistance and Stroke Risk: Platelet Function Analysis in Patients With Ischemic Events Completed NCT01586975 Phase 2, Phase 3 Clopidogrel;Aspirin 81 mg;Aspirin >300 mg
20 The Effects of Omega-3 Fatty Acids on Aspirin Resistance Completed NCT00771914 Phase 1, Phase 2 Aspirin;Lovaza;Both Aspirin and Lovaza
21 Aspirin Resistance and Percutaneous Coronary Intervention (PCI) Completed NCT01103440 Phase 2 Intravenous Glycoprotein inhibitor + ASA, Clopidogrel;Antiplatelet Therapy (ASA, Clopidogrel)
22 Fish Oil and Aspirin With Type 2 Diabetes Completed NCT01181882 Phase 2
23 Effect of Low Dose Aspirin on Birthweight in Twins: The GAP Trial. Completed NCT02280031 Phase 2 Acetylsalicylic Acid;Placebo
24 In-Vivo Bleeding Volume Test for Platelet-Aspirin Interaction Unknown status NCT01047722 Phase 1 Aspirin ingestion followed by doing a Bleeding Volume Test
25 Mechanism Based Resistance to Aspirin Completed NCT00948987 Phase 1 Aspirin
26 Aspirin Resistance in Systemic Lupus Erythematosus (SLE) Completed NCT00731302 Phase 1 aspirin and meloxicam
27 Investigation of Platelet Function and Aspirin Resistance in Chronic Dialysis Patient Unknown status NCT01045785
28 Prevalence and Level of Thienopyridine Resistance Seen in a Contemporary Percutaneous Coronary Intervention or Coronary Artery Bypass Graft Population Unknown status NCT01408927
29 Platelet Reactivity and MES During CEA Unknown status NCT01547039
30 Relationship Between Level of Hemoglobin A1c and Platelet Function in Patients Undergoing Cardiac Surgery Unknown status NCT02711124
31 Prevalence and Profile of Aspirin Resistance in Hemodialysis Patients Completed NCT00792272
32 Aspirin Resistance and Prognosis of Patients With Critical Limb Ischaemia Completed NCT01104441
33 Prevalence of Aspirin Resistance in Chronic Kidney Disease Patients Completed NCT01364779
34 The Effect of Serum LDL Lowering on Aspirin Resistance Completed NCT00466154 Not Applicable Aspirin
35 Danish Aspirin Resistance Trial - Pilot Study Completed NCT00389129 Not Applicable acetylsalicylic acid
36 Aspirin Resistance in Coronary Artery Disease Completed NCT00753935 Early Phase 1 enteric-coated aspirin;Chewable aspirin
37 Aspirin Resistance in Women With Migraine Withdrawn NCT01257893 Not Applicable Aspirin (acetylsalicylic acid);Placebo
38 Laboratory Aspirin Resistance in Diabetics and Non-Diabetics Completed NCT00563875 Not Applicable acetylsalicylic acid
39 The Study on Profile and Genetic Factors of Aspirin Resistance (ProGEAR Study) Completed NCT00250380
40 Enteric Coating as a Factor in Aspirin Resistance Completed NCT00531362 Plain aspirin
41 Aspirin Resistance and Sleep Apnea in Type-2 Diabetic Patients Terminated NCT01788930 Not Applicable
42 Effect of Glucose Control on the Response to Aspirin in Type 2 Diabetic Patients Completed NCT00649909
43 The Efficacy of Aspirin in the Postoperative Period in Vascular Surgery Completed NCT01432652
44 Aspirin Resistance Following Coronary Bypass Surgery Terminated NCT00260377 Not Applicable
45 Genotypic and Phenotypic Correlates of Resistance to Aspirin Completed NCT01361620 Not Applicable aspirin
46 Measurement of Platelet Dense Granule Release in Healthy Volunteers Withdrawn NCT00942617 Not Applicable Aspirin
47 Aspirin Responsiveness and Outcome in Coronary Artery Bypass Graft (CABG) Surgery Completed NCT01174862
48 Optimum Platelet Inhibition After Coronary Bypass Surgery Completed NCT00262275 Not Applicable Aspirin, Clopidogrel
49 Aspirin Responsiveness in Women With Coronary Artery Disease Completed NCT01406990
50 Platelet Reactivity In Patients With Nuisance Bleeding On A Thienopyridine Completed NCT01152229

Search NIH Clinical Center for Aspirin Resistance

Genetic Tests for Aspirin Resistance

Anatomical Context for Aspirin Resistance

MalaCards organs/tissues related to Aspirin Resistance:

41
Testes, Heart, Kidney, Endothelial, Whole Blood

Publications for Aspirin Resistance

Articles related to Aspirin Resistance:

(show top 50) (show all 399)
# Title Authors Year
1
Aspirin Resistance: Risk Factors and Prognostic Significance in Patients with Cerebral Small Vessel Disease. ( 29530996 )
2018
2
The Relationship Between Aspirin Resistance and Carotid Imaging in Young Patients With ST-Segment Elevated Myocardial Infarction: A Cross-Sectional Study. ( 29888621 )
2018
3
Aspirin Resistance: Cardiovascular Risk Game Changer. ( 29757761 )
2018
4
Effects of Ramadan fasting on aspirin resistance in type 2 diabetic patients. ( 29529091 )
2018
5
Associations Between PFA-Measured Aspirin Resistance, Platelet Count, Renal Function, and Angiotensin Receptor Blockers. ( 29996660 )
2018
6
Aspirin resistance predicts unfavorable functional outcome in acute ischemic stroke patients. ( 30016728 )
2018
7
Effects of aspirin resistance and mean platelet volume on vascular access failure in hemodialysis patients. ( 30025441 )
2018
8
Investigation into the causes of aspirin resistance in healthy dogs. ( 30302763 )
2018
9
Prevalence of aspirin resistance by thromboelastography plus platelet mapping in children with CHD: a single-centre experience. ( 30501653 )
2018
10
Aspirin resistance in the early postoperative period: Pharmacokinetics may be part of the answer. ( 30538026 )
2018
11
Global Trends in Aspirin Resistance-Related Research from 1990 to 2015: A Bibliometric Analysis. ( 28667787 )
2017
12
Genetic signatures in ischemic stroke: Focus on aspirin resistance. ( 28969559 )
2017
13
Suspected aspirin resistance in individual healthy adult warmblood horses. ( 28390056 )
2017
14
My Approach to the patient with CAD and aspirin resistance. ( 28865598 )
2017
15
Aspirin resistance are associated with long-term recurrent stroke events after ischaemic stroke. ( 28842303 )
2017
16
Interaction among COX-2, P2Y1 and GPIIIa gene variants is associated with aspirin resistance and early neurological deterioration in Chinese stroke patients. ( 28068952 )
2017
17
Association of GPIa and COX-2 gene polymorphism with aspirin resistance. ( 28948649 )
2017
18
Targeting aspirin resistance with nutraceuticals: a possible strategy for reducing cardiovascular morbidity and mortality. ( 28912955 )
2017
19
The incidence of aspirin resistance in heart transplantation recipients. ( 28747943 )
2017
20
Over-expression of cyclooxygenase-2 in increased reticulated platelets leads to aspirin resistance after elective off-pump coronary artery bypass surgery. ( 29149707 )
2017
21
Decreased turnover aspirin resistance by bidaily aspirin intake and efficient cytoreduction in myeloproliferative neoplasms. ( 29090588 )
2017
22
Post-pregnancy aspirin resistance appears not to be related with recurrent hypertensive disorders of pregnancy. ( 28033561 )
2017
23
rs5911 and rs3842788 Genetic Polymorphism, Blood Stasis Syndrome, and Plasma TXB2 and hs-CRP Levels Are Associated with Aspirin Resistance in Chinese Chronic Stable Angina Patients. ( 28465708 )
2017
24
Prevalence of aspirin resistance in patients with type II diabetes: a descriptive-analytical studya8c. ( 28025961 )
2017
25
Biochemical aspirin resistance is associated with increased stroke severity and infarct volumes in ischemic stroke patients. ( 29100372 )
2017
26
Platelet Carbonic Anhydrase II, a Forgotten Enzyme, May Be Responsible for Aspirin Resistance. ( 29090039 )
2017
27
PFA-100-measured aspirin resistance is the predominant risk factor for hospitalized cardiovascular events in aspirin-treated patients: A 5-year cohort study. ( 29055181 )
2017
28
Aspirin resistance in coronary heart disease: Current understandings and strategies. ( 28191510 )
2016
29
The effectiveness of antioxidant therapy in aspirin resistance, diabetes population for prevention of thrombosis. ( 27393925 )
2016
30
Aspirin Resistance Predicts Adverse Cardiovascular Events in Patients with Symptomatic Peripheral Artery Disease. ( 28100965 )
2016
31
Aspirin resistance in cerebrovascular disease and the role of glycoprotein IIIa polymorphism in Turkish stroke patients. ( 26809135 )
2016
32
Interaction between COX-1 and COX-2 Variants Associated with Aspirin Resistance in Chinese Stroke Patients. ( 27318652 )
2016
33
Prevalence of aspirin resistance in Asian-Indian patients with stable coronary artery disease. ( 24482126 )
2016
34
A brief review on the mechanisms of aspirin resistance. ( 27372038 )
2016
35
A study into the genetic basis of aspirin resistance in Pakistani patients with coronary artery disease. ( 27393450 )
2016
36
High prevalence of aspirin resistance in elderly patients with cardiovascular disease and metabolic syndrome. ( 27582771 )
2016
37
Establishing a predictive model for aspirin resistance in elderly Chinese patients with chronic cardiovascular disease. ( 27594876 )
2016
38
Aspirin resistance and other aspirin-related concerns. ( 26573589 )
2016
39
The Interplay between Stroke Severity, Antiplatelet Use, and Aspirin Resistance in Ischemic Stroke. ( 26576697 )
2016
40
Does high serum uric acid level cause aspirin resistance? ( 26656902 )
2016
41
Low dose aspirin and pregnancy: how important is aspirin resistance? ( 26929162 )
2016
42
Investigating the role of aspirin resistance in obstetrics may optimise prevention of pre-eclampsia. ( 26969603 )
2016
43
The lack of aspirin resistance in patients with coronary artery disease. ( 26980433 )
2016
44
Aspirin resistance is associated with increased stroke severity and infarct volume. ( 27060166 )
2016
45
Multiple Electrode Aggregometry is an adequate method for aspirin response testing in myeloproliferative neoplasms and differentiates the mechanisms of aspirin resistance. ( 27105311 )
2016
46
Chinese Herbal Medicine for Aspirin Resistance: A Systematic Review and Meta-Analysis. ( 27153119 )
2016
47
Aspirin resistance may be identified by miR-92a in plasma combined with platelet distribution width. ( 27208561 )
2016
48
Aspirin Resistance in Different Doses by Bleeding Time and Urinary 11-dehydro-thromboxane B2. ( 29953191 )
2016
49
Aspirin resistance in patients undergoing hemodialysis and effect of hemodialysis on aspirin resistance. ( 23698727 )
2015
50
Impact of aspirin resistance on outcomes among patients following coronary artery bypass grafting: exploratory analysis from randomized controlled trial (NCT01159639). ( 25095738 )
2015

Variations for Aspirin Resistance

Expression for Aspirin Resistance

Search GEO for disease gene expression data for Aspirin Resistance.

Pathways for Aspirin Resistance

Pathways related to Aspirin Resistance according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.57 ITGA2 ITGB3 PTGS2
2 12.5 HMOX1 ITGA2 PTGS2
3 12.24 HMOX1 PTGS1 PTGS2
4 12.18 HMOX1 ITGB3 PTGS2
5
Show member pathways
12.04 ITGB3 PTGS1 PTGS2
6
Show member pathways
11.88 APOB PTGS1 PTGS2
7 11.6 ITGA2 ITGB3
8 11.58 ITGA2 PTGS2
9 11.53 ITGA2 ITGB3
10 11.52 ITGA2 ITGB3 PTGS1
11 11.44 ITGB3 PTGS2
12
Show member pathways
11.41 ITGA2 ITGB3
13 11.34 PTGS1 PTGS2
14 11.32 ITGA2 ITGB3
15 11.29 PTGS1 PTGS2
16 11.28 HMOX1 ITGB3 PTGS2
17 11.14 ITGA2 ITGB3
18 10.99 PTGS1 PTGS2
19 10.94 PTGS1 PTGS2
20
Show member pathways
10.89 PTGS1 PTGS2
21 10.84 ITGA2 ITGB3 PTGS1
22 10.81 PTGS1 PTGS2
23 10.77 PTGS1 PTGS2
24 10.5 PTGS1 PTGS2
25 10.08 HMOX1 PTGS1 PTGS2

GO Terms for Aspirin Resistance

Cellular components related to Aspirin Resistance according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.62 APOB HMOX1 PTGS1 PTGS2
2 endoplasmic reticulum membrane GO:0005789 9.46 APOB HMOX1 PTGS1 PTGS2
3 caveola GO:0005901 9.26 HMOX1 PTGS2
4 integrin complex GO:0008305 8.96 ITGA2 ITGB3
5 intracellular membrane-bounded organelle GO:0043231 8.92 APOB HMOX1 PTGS1 PTGS2

Biological processes related to Aspirin Resistance according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.74 APOB PTGS1 PTGS2
2 wound healing GO:0042060 9.61 ITGA2 ITGB3
3 cell-matrix adhesion GO:0007160 9.6 ITGA2 ITGB3
4 integrin-mediated signaling pathway GO:0007229 9.59 ITGA2 ITGB3
5 response to organic substance GO:0010033 9.58 APOB PTGS2
6 viral entry into host cell GO:0046718 9.58 ITGA2 ITGB3
7 cellular oxidant detoxification GO:0098869 9.56 PTGS1 PTGS2
8 cellular response to mechanical stimulus GO:0071260 9.55 ITGA2 PTGS2
9 fatty acid biosynthetic process GO:0006633 9.54 PTGS1 PTGS2
10 cellular response to heat GO:0034605 9.52 HMOX1 PTGS2
11 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.51 HMOX1 PTGS2
12 low-density lipoprotein particle clearance GO:0034383 9.49 APOB HMOX1
13 cell adhesion mediated by integrin GO:0033627 9.48 ITGA2 ITGB3
14 prostaglandin metabolic process GO:0006693 9.46 PTGS1 PTGS2
15 positive regulation of smooth muscle contraction GO:0045987 9.43 ITGA2 PTGS2
16 cell-substrate adhesion GO:0031589 9.4 ITGA2 ITGB3
17 prostaglandin biosynthetic process GO:0001516 9.37 PTGS1 PTGS2
18 response to oxidative stress GO:0006979 9.33 HMOX1 PTGS1 PTGS2
19 mesodermal cell differentiation GO:0048333 9.32 ITGA2 ITGB3
20 cyclooxygenase pathway GO:0019371 9.26 PTGS1 PTGS2
21 regulation of blood pressure GO:0008217 9.13 HMOX1 PTGS1 PTGS2
22 positive regulation of smooth muscle cell proliferation GO:0048661 8.8 HMOX1 ITGA2 PTGS2

Molecular functions related to Aspirin Resistance according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.43 HMOX1 ITGB3 PTGS2
2 dioxygenase activity GO:0051213 9.37 PTGS1 PTGS2
3 virus receptor activity GO:0001618 9.32 ITGA2 ITGB3
4 peroxidase activity GO:0004601 9.16 PTGS1 PTGS2
5 heme binding GO:0020037 9.13 HMOX1 PTGS1 PTGS2
6 prostaglandin-endoperoxide synthase activity GO:0004666 8.62 PTGS1 PTGS2

Sources for Aspirin Resistance

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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