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MCID: ASP030
MIFTS: 42

Aspirin Resistance

Categories: Blood diseases, Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Aspirin Resistance

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MalaCards integrated aliases for Aspirin Resistance:

Name: Aspirin Resistance 57
Aspirin, Resistance to Cardioprotective Effect of 57
Aspirin, Resistance to Antithrombotic Effect of 57
Aspirin Cardioprotective Effect of 57
Aspirin Antithrombotic Effect of 57

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM 57 608223
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Summaries for Aspirin Resistance

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OMIM : 57 Aspirin (acetylsalicylic acid) is a classic nonsteroidal antiinflammatory agent that irreversibly inhibits type I cyclooxygenase (PTGS1, or COX1; 176805) in platelets, resulting in decreased production of thromboxane A2 (TXA2) and inhibition of platelet aggregation. Because of this feature, it is used therapeutically to prevent cardiothrombotic events. Individuals show a variable response to the drug, referred to as aspirin ineffectiveness or resistance, in which not all individuals or populations appear to receive the full prophylactic or therapeutic benefits (summary by Zhou et al., 2011). Halushka and Halushka (2002) discussed a possible basis for resistance to the cardioprotective effect of aspirin. (608223)

MalaCards based summary : Aspirin Resistance, also known as aspirin, resistance to cardioprotective effect of, is related to active peptic ulcer disease and clopidogrel resistance. An important gene associated with Aspirin Resistance is PTGS1 (Prostaglandin-Endoperoxide Synthase 1), and among its related pathways/superpathways are Focal Adhesion and MicroRNAs in cancer. The drugs Cilostazol and Dipyridamole have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and kidney, and related phenotypes are cardiovascular system and homeostasis/metabolism

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Related Diseases for Aspirin Resistance

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Diseases related to Aspirin Resistance via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 active peptic ulcer disease 29.9 PTGS2 PTGS1
2 clopidogrel resistance 29.3 PTGS2 ITGB3 ABCB1
3 myocardial infarction 27.7 PTGS2 PTGS1 ITGB3 ITGA2 APOB
4 hyperlipoproteinemia, type iii 10.5
5 coronary artery anomaly 10.5
6 arteries, anomalies of 10.5
7 cerebrovascular disease 10.4
8 vascular disease 10.4
9 stroke, ischemic 10.4
10 ischemia 10.4
11 intermediate coronary syndrome 10.3
12 peripheral vascular disease 10.2
13 heart disease 10.2
14 morphine dependence 10.2 PTGS2 PTGS1
15 hydrops, lactic acidosis, and sideroblastic anemia 10.2 PTGS2 PTGS1
16 hypercholesterolemia, familial, 1 10.1
17 antenatal bartter syndrome 10.1 PTGS2 PTGS1
18 coronary heart disease 1 10.1
19 gas gangrene 10.1
20 gastric ulcer 10.1 PTGS2 PTGS1
21 dyspepsia 10.1 PTGS2 PTGS1
22 body mass index quantitative trait locus 1 10.1
23 diabetes mellitus 10.1
24 stomach disease 10.0 PTGS2 PTGS1
25 thrombosis 10.0
26 pre-eclampsia 10.0
27 transient cerebral ischemia 10.0
28 lipid metabolism disorder 10.0
29 chronic acquired demyelinating polyneuropathy 10.0
30 angioedema 10.0 PTGS2 PTGS1
31 gastroesophageal reflux 10.0 PTGS2 PTGS1
32 headache 10.0 PTGS2 ABCB1
33 atherosclerosis susceptibility 10.0
34 angina pectoris 10.0
35 diabetic angiopathy 10.0
36 carotid stenosis 10.0
37 intermittent claudication 10.0
38 kidney disease 10.0
39 urticaria 10.0 PTGS2 PTGS1
40 homocysteinemia 9.9
41 limb ischemia 9.9
42 eclampsia 9.9
43 essential thrombocythemia 9.9
44 coronary stenosis 9.9
45 chronic kidney disease 9.9
46 acute myocardial infarction 9.9
47 fetal and neonatal alloimmune thrombocytopenia 9.9 ITGB3 ITGA2
48 proteasome-associated autoinflammatory syndrome 1 9.9 PTGS2 PTGS1
49 thrombocytopenia due to platelet alloimmunization 9.9 ITGB3 ITGA2
50 primary thrombocytopenia 9.8 ITGB3 ITGA2

Graphical network of the top 20 diseases related to Aspirin Resistance:



Diseases related to Aspirin Resistance
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Symptoms & Phenotypes for Aspirin Resistance

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Clinical features from OMIM:

608223

MGI Mouse Phenotypes related to Aspirin Resistance:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.83 ABCB1 APOB ITGB3 PTGS1 PTGS2
2 homeostasis/metabolism MP:0005376 9.8 ABCB1 APOB ITGA2 ITGB3 PTGS1 PTGS2
3 hematopoietic system MP:0005397 9.77 ABCB1 ITGA2 ITGB3 PTGS1 PTGS2
4 digestive/alimentary MP:0005381 9.71 ABCB1 ITGB3 PTGS1 PTGS2
5 immune system MP:0005387 9.65 ABCB1 APOB ITGB3 PTGS1 PTGS2
6 liver/biliary system MP:0005370 9.46 ABCB1 APOB ITGB3 PTGS2
7 muscle MP:0005369 9.26 APOB ITGB3 PTGS1 PTGS2
8 reproductive system MP:0005389 9.02 ABCB1 APOB ITGB3 PTGS1 PTGS2
Sources

Drugs & Therapeutics for Aspirin Resistance

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Drugs for Aspirin Resistance (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
2
Dipyridamole Approved Phase 4 58-32-2 3108
3
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
4
Tirofiban Approved Phase 4 144494-65-5 60947
5
Bivalirudin Approved, Investigational Phase 4 128270-60-0 16129704
6
Triflusal Approved, Investigational Phase 4 322-79-2
7
Thrombin Approved, Investigational Phase 4
8
Atorvastatin Approved Phase 4 134523-00-5 60823
9
Pravastatin Approved Phase 4 81093-37-0 54687
10
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
11
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
12 Acetylsalicylic acid lysinate Phase 4
13 lysine Phase 4
14 Neuroprotective Agents Phase 4
15 Respiratory System Agents Phase 4
16 Protective Agents Phase 4
17 Phosphodiesterase Inhibitors Phase 4
18 Anti-Asthmatic Agents Phase 4
19 Vasodilator Agents Phase 4
20 Phosphodiesterase 3 Inhibitors Phase 4
21 Autonomic Agents Phase 4
22 Bronchodilator Agents Phase 4
23 Aspirin, Dipyridamole Drug Combination Phase 4
24 Anti-Infective Agents Phase 4
25 Immunologic Factors Phase 4
26 Radiation-Protective Agents Phase 4
27 Anti-Bacterial Agents Phase 4
28 Antibiotics, Antitubercular Phase 4
29 Adjuvants, Immunologic Phase 4
30 polysaccharide-K Phase 4
31 Interferon Inducers Phase 4
32 calcium heparin Phase 4
33 interferons Phase 4
34 Antiviral Agents Phase 4
35 Hemostatics Phase 4
36 Coagulants Phase 4
37 Salicylates Phase 4
38 Hormones Phase 4
39 Lipid Regulating Agents Phase 4
40 Chinese Salvia Phase 4
41 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
42 Hypolipidemic Agents Phase 4
43 Calcium, Dietary Phase 4
44 Anticholesteremic Agents Phase 4
45 Antimetabolites Phase 4
46
Esomeprazole Approved, Investigational Phase 3 119141-88-7, 161796-78-7, 161973-10-0 9568614 4594
47 Gastrointestinal Agents Phase 3
48 Antacids Phase 3
49 Proton Pump Inhibitors Phase 3
50 Anti-Ulcer Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 65)
# Name Status NCT ID Phase Drugs
1 Impact of Different Pharmacological Formulations on Aspirin Resistance Reversibility in Diabetics Patients Unknown status NCT01935193 Phase 4 lysine acetylsalicylate
2 a Comparative Study of Aspirin Either at Fixed Dose or at a Dose Titrated by Platlet Function Analyzer(PFA-100) vs Placebo in Primary Prevention of Vascular Access for Hemodialysis Unknown status NCT02055131 Phase 4 aspirin
3 Effect of aSpirin Versus CilOstazol for Inhibition of Antiplatelet aggRegaTion in Type 2 DM Patients Unknown status NCT02933788 Phase 4 Cilostazol;Acetylsalicylic acid
4 Validation of the Clinical Applicability of Various Platelet Function Assessments in High-Risk Atherothrombotic Patients Undergoing Percutaneous Coronary Angioplasty: Phase 4 Study Unknown status NCT00513149 Phase 4 Clopidogrel
5 Phase 4 Study of Additional Cilostazol for Overcoming Biochemical Aspirin Resistance in the Chronic Stroke Patients Completed NCT00446641 Phase 4 Cilostazol;placebo
6 A Randomised, Crossover Study Comparing the Biochemical and Platelet Effects of Modified-release Dipyridamole/Aspirin (200mg/25 mg bd; Asasantin Retard®) With Aspirin (75 mg qd) in Coronary Artery Disease Patients With Aspirin Resistance Manifesting as Persistent Thromboxane Formation. Completed NCT00129038 Phase 4 modified-release dipyridamole/aspirin;aspirin
7 Aspirin Responsiveness in Women at Risk for Cardiac Events: A Pilot Study. Completed NCT00818337 Phase 4 Aspirin
8 Dual Antiplatelet Therapy in Patients With Aspirin Resistance Following Coronary Artery Bypass Grafting Completed NCT01159639 Phase 4 Clopidogrel
9 Aspirin Non-responsiveness and Clopidogrel Endpoint Trial. Completed NCT00222261 Phase 4 aspirin;clopidogrel
10 Tailoring Treatment With Tirofiban in Patients Showing Resistance to Aspirin and/or Resistance to Clopidogrel Completed NCT00398463 Phase 4 Tirofiban;Placebo
11 Prevalence of Resistance to Aspirin and/or Clopidogrel Among Patients With PAD. Prognostic Significance of Resistance to Aspirin Completed NCT00262561 Phase 4 Aspirin
12 Comparison of Triflusal With Aspirin in the Secondary Prevention of Atherothrombotic Events Completed NCT02616497 Phase 4 Aspirin;Triflusal
13 Studies of Traditional Chinese Medicine Clinical Efficacy Evaluation Index With Stable Angina Pectoris of Coronary Heart Disease as an Example Completed NCT01502943 Phase 4 Louxiangdan Tongxin granules;TCM granules placebo;Chixiangshen Tongxin granules;TCM granule placebo plus western basis treatment;Western basis treatment
14 Aspirin Statins Or Both For The Reduction Of Thrombin Generation In Diabetic People Completed NCT00793754 Phase 4 Aspirin;Atorvastatin;Aspirin + Atorvastatin
15 The Effect of 81mg vs 162mg ASA for Preeclampsia Prevention in Obese Women at High Risk for Developing Preeclampsia Recruiting NCT03735433 Phase 4 162mg aspirin dose
16 Efficacy of Monitoring of Aspirin Responsiveness in the Prevention of Cardiovascular Events and Decrease in Bleeding Complications in Patients With End-Stage Kidney Disease Undergoing Hemodialysis Withdrawn NCT01198379 Phase 4 aspirin;Placebo
17 Clinical Management of Antiplatelet Drug Resistance in Patients With Drug Eluting Coronary Stents Withdrawn NCT00589862 Phase 4 Plavix (Clopidogrel)
18 Methods to Augment the Efficacy of Aspirin and Clopidogrel in Healthy Subjects (ASA Only) and Patients With Stable Coronary Artery Disease (Taking Clopidogrel Only) or (Taking Clopidogrel & ASA) With an Elevated Platelet Turnover (Reticulated Platelets). Withdrawn NCT01011257 Phase 4 Asprin;Clopidogrel
19 ThrombElastoGraphic Haemostatic Status and Antiplatelet Therapy After Coronary Artery Bypass Graft Surgery(TEG-CABG Trial):Does Intensified Postoperative Antiplatelet Therapy in Preoperatively Identified Hypercoagulable Patients Improve Outcome After CABG Surgery Unknown status NCT01046942 Phase 3 Clopidogrel+acetylsalicylic acid;acetylsalicylic acid
20 Thromboelastography As An Assessment Tool for Possible Clopidogrel and Aspirin Resistance in The Patients Treated With Primary PCI for STEMI Unknown status NCT00697021 Phase 3 Aspirin (200mg) and/or Plavix (150mg) dosage according to TEG;Aspirin 100mg and Plavix 75mg
21 A Phase III, Randomized, Study of Aspirin and Esomeprazole Chemoprevention in Barrett's Metaplasia Unknown status NCT00357682 Phase 3 Esomeprazole;Esomeprazole;Aspirin
22 Pilot Study of Preoperative Aspirin and Postoperative Clopidogrel's Effects on Graft Patency and Cardiac Events in Coronary Artery Bypass Surgery Completed NCT00330772 Phase 3 Aspirin;Clopidogrel
23 Multiple Daily Doses of Aspirin to Overcome Hyporesponsiveness Post Cardiac Bypass Surgery (ASACABG)- Part B Completed NCT01902498 Phase 2 Aspirin;Aspirin;Aspirin
24 The Effects of Omega-3 Fatty Acids on Aspirin Resistance Completed NCT00771914 Phase 1, Phase 2 Aspirin;Lovaza;Both Aspirin and Lovaza
25 Multiple Daily Doses Of Aspirin To Overcome Aspirin Hyporesponsiveness Post Cardiac Bypass Surgery Completed NCT01618006 Phase 2 Aspirin;Aspirin;Aspirin
26 The Effects of Fish Oil and Aspirin on Cardiovascular Risk in Type 2 Diabetes Completed NCT01181882 Phase 2
27 ASpirin as a Treatment for ARDS (STAR): a Phase 2 Randomised Control Trial Terminated NCT02326350 Phase 2 Aspirin 75mg;Lactose powder
28 Bleeding Volume Test: A Double-Blind Crossover Randomized Clinical Trial of an In-Vivo On-Line Test for Aspirin Effect and Resistance Unknown status NCT01047722 Phase 1 Aspirin ingestion followed by doing a Bleeding Volume Test
29 Mechanism Based Resistance to Aspirin Completed NCT00948987 Phase 1 Aspirin
30 Vascular Damage in Systemic Lupus Erythematosus (SLE) Completed NCT00731302 Phase 1 aspirin and meloxicam
31 Phase 1 Study to Assess the Safety of 500mg of Aspirin Added to IV TPA at Standard Doses to Prevent Re-occlusion of Cerebral Vessels After Successful Reperfusion. Withdrawn NCT00417898 Phase 1 Aspirin
32 Investigation of Platelet Function and Aspirin Resistance in Chronic Dialysis Patient Unknown status NCT01045785
33 Prevalence and Level of Thienopyridine Resistance Seen in a Contemporary PCI and CABG Population Unknown status NCT01408927
34 Is There A LIfe for DES After Discontinuation of Clopidogrel:The ITALIC PLUS Trial Unknown status NCT01476020
35 Thrombin Dysregulation Leads to Early Saphenous Vein Graft Failure Unknown status NCT00481806
36 Effects of Prescription OMega-3 Fatty Acids (Omacor®, Lovaza®) on Platelet Activity in Patients With Coronary Artery Disease With Hypertriglyceridemia (OMPA-CAD) Unknown status NCT01086163 Omacor, omega-3 fatty acids in CAD patients
37 Identification of Novel Molecular Markers for Cerebral Ischemia From Patients With Minor and Devastating Ischemic Injury Unknown status NCT02389647
38 Prevalence of Aspirin Resistance in Hemodialysis Patients Completed NCT00792272
39 Prevalence of Aspirin Resistance in Chronic Kidney Disease Patients Completed NCT01364779
40 Cardiovascular Events at One Year of Patients Hospitalized for Critical Limb Ischaemia and Aspirin Resistant Using the VerifyNow®. Aspirin Resistance and Prognosis of Patients With Critical Limb Ischaemia Completed NCT01104441
41 Genotypic and Phenotypic Correlates of Resistance to Anti-platelet Actions of Aspirin in an At-risk Patient Population and in the General Population Completed NCT01361620 aspirin
42 Effect of Glucose Control on the Response to Aspirin in Type 2 Diabetic Patients Completed NCT00649909
43 Aspirin Responsiveness in Women With Coronary Artery Disease Completed NCT01406990
44 Comparative Evaluation of Aspirin Resistance With Point-of-Care Testing - Danish Aspirin Resistance Trial (DANART) - Pilot Study Completed NCT00389129 acetylsalicylic acid
45 Evaluation of Aspirin Resistance at a Molecular Level in Aspirin-Treated Patients With Coronary Artery Disease Completed NCT00753935 Early Phase 1 enteric-coated aspirin;Chewable aspirin
46 Laboratory Aspirin Resistance in Coronary Artery Disease Patients With or Without Diabetes Mellitus Completed NCT00563875 acetylsalicylic acid
47 Optimum Platelet Inhibition After Coronary Artery Bypass Surgery: A Randomised Trial Comparing Platelet Aggregation Using Low, Medium Dose Aspirin and Clopidogrel Completed NCT00262275 Aspirin, Clopidogrel
48 The Study on Profile and Genetic Factors of Aspirin Resistance (ProGEAR Study)－A Prospective Multicenter Cohort Study- Completed NCT00250380
49 Aspirin Resistance in Obstructive Sleep Apnea Patients (ARISA Trial) Completed NCT03930875
50 The Effect of Serum LDL Lowering on Aspirin Resistance Completed NCT00466154 Aspirin

Search NIH Clinical Center for Aspirin Resistance

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Genetic Tests for Aspirin Resistance

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Anatomical Context for Aspirin Resistance

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MalaCards organs/tissues related to Aspirin Resistance:

41
Testes, Heart, Kidney, Endothelial, Whole Blood, Monocytes
Sources

Publications for Aspirin Resistance

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Articles related to Aspirin Resistance:

(show top 50) (show all 710)
# Title Authors PMID Year
1
Intracellular erythrocyte platelet-activating factor acetylhydrolase I inactivates aspirin in blood. 38 8
21844189 2011
2
Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events. 38 8
11940542 2002
3
Profile and prevalence of aspirin resistance in patients with cardiovascular disease. 38 8
11472699 2001
4
Development of aspirin resistance in persons with previous ischemic stroke. 38 8
7974569 1994
5
Why are some individuals resistant to the cardioprotective effects of aspirin? Could it be thromboxane A2? 8
11940535 2002
6
One hundred years of aspirin. 8
9259670 1997
7
Collaborative overview of randomised trials of antiplatelet therapy--II: Maintenance of vascular graft or arterial patency by antiplatelet therapy. Antiplatelet Trialists' Collaboration. 8
8312766 1994
8
Collaborative overview of randomised trials of antiplatelet therapy--I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration. 8
8298418 1994
9
Collaborative overview of randomised trials of antiplatelet therapy--III: Reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients. Antiplatelet Trialists' Collaboration. 8
8054013 1994
10
Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. 8
1907252 1991
11
Aspirin selectively inhibits prostaglandin production in human platelets. 8
5284361 1971
12
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. 8
5284360 1971
13
Experiences with aspirin (Acetylsalicylic acid) in the nonspecific prophylaxis of coronary thrombosis. 8
13013156 1953
14
[Network pharmacology-based study on mechanisms of Danhong Injection in treatment of aspirin resistance]. 38
31359682 2019
15
Metabolic Syndrome and the Effectiveness of Low-dose Aspirin on Reproductive Outcomes. 38
30985534 2019
16
Assessment of the relationship between platelet reactivity, vascular risk factors and gender in cerebral ischaemia patients. 38
31343071 2019
17
Aspirin Resistance Incidence and Associations Between Aspirin Effect and Outcomes in Cardiac Surgery. 38
31238032 2019
18
Platelet Surface CD62p and Serum Vitamin D Levels are Associated with Clopidogrel Resistance in Chinese Patients with Ischemic Stroke. 38
30795966 2019
19
Aspirin and Clopidogrel Resistance in Indian Patients with Ischemic Stroke and its Associations with Gene Polymorphisms: A Pilot Study. 38
31007424 2019
20
Evaluation of platelet reactivity during combined antiplatelet therapy in patients with stable coronary artery disease in relation to diabetes type 2 and the GPIIB/IIIA receptor gene polymorphism. 38
31356179 2019
21
Obesity and laboratory aspirin resistance in high-risk pregnant women treated with low-dose aspirin. 38
30786253 2019
22
Aspirin resistance mediated by oxidative stress-induced 8-Isoprostaglandin F2. 38
30989683 2019
23
Investigation into the causes of aspirin resistance in healthy dogs. 38
30302763 2019
24
Identification of aspirin resistance using a PDW-miR92a-score: Validation in an intermittent claudication cohort. 38
30586555 2019
25
Prevalence of aspirin resistance by thromboelastography plus platelet mapping in children with CHD: a single-centre experience. 38
30501653 2019
26
Association of Aspirin Resistance with Increased Mortality in Ischemic Stroke. 38
30820515 2019
27
Complex roles of the old drug aspirin in cancer chemoprevention and therapy. 38
29855050 2019
28
Clopidogrel-associated genetic variants on inhibition of platelet activity and clinical outcome for acute coronary syndrome patients. 38
30098132 2019
29
Diabetes and Platelet Response to Low-Dose Aspirin. 38
30265320 2018
30
Decreased turnover aspirin resistance by bidaily aspirin intake and efficient cytoreduction in myeloproliferative neoplasms. 38
29090588 2018
31
Aspirin resistance in the early postoperative period: Pharmacokinetics may be part of the answer. 38
30538026 2018
32
Multifaceted effects of arachidonic acid and interaction with cyclic nucleotides in human platelets. 38
30240944 2018
33
The Relationship Between Aspirin Resistance and Carotid Imaging in Young Patients With ST-Segment Elevated Myocardial Infarction: A Cross-Sectional Study. 38
29888621 2018
34
Aspirin in primary prevention for patients with diabetes: Still a matter of debate. 38
30011059 2018
35
Correlation of Cardiovascular Risk Factors and Biomarkers With Platelet Reactivity in Coronary Artery Disease. 38
30418226 2018
36
Aspirin resistance predicts unfavorable functional outcome in acute ischemic stroke patients. 38
30016728 2018
37
Evidence and prospective of plant derived flavonoids as antiplatelet agents: Strong candidates to be drugs of future. 38
29448091 2018
38
Effects of aspirin resistance and mean platelet volume on vascular access failure in hemodialysis patients. 38
30025441 2018
39
Association of GPIa and COX-2 gene polymorphism with aspirin resistance. 38
28948649 2018
40
Aspirin Resistance: Cardiovascular Risk Game Changer. 38
29757761 2018
41
Potential of Anthocyanin to Prevent Cardiovascular Disease in Diabetes. 38
29477135 2018
42
Gene polymorphisms in dual antiplatelet therapy and the presence of hypo-attenuated leaflet thickening after transcatheter aortic valve replacement. 38
29478129 2018
43
Proteinuria Predicts Resistance to Antiplatelet Therapy in Ischemic Stroke. 38
28875481 2018
44
PFA-100-measured aspirin resistance is the predominant risk factor for hospitalized cardiovascular events in aspirin-treated patients: A 5-year cohort study. 38
29055181 2018
45
REduction of THRomboembolic EVents during Ablation using the laserballoon: The RETHREVA registry. 38
29315961 2018
46
Antiplatelet Potential of Plant-Derived Glycosides as Possible Lead Compounds. 38
29283063 2018
47
Associations Between PFA-Measured Aspirin Resistance, Platelet Count, Renal Function, and Angiotensin Receptor Blockers. 38
29996660 2018
48
Effects of Ramadan fasting on aspirin resistance in type 2 diabetic patients. 38
29529091 2018
49
Aspirin Resistance: Risk Factors and Prognostic Significance in Patients with Cerebral Small Vessel Disease. 38
29530996 2018
50
The association between aspirin resistance and extent and severity of coronary atherosclerosis. 38
30859163 2018
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Variations for Aspirin Resistance

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Expression for Aspirin Resistance

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Search GEO for disease gene expression data for Aspirin Resistance.
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Pathways for Aspirin Resistance

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Pathways related to Aspirin Resistance according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Focal Adhesion 37 1
Show member pathways
 12.55 PTGS2 ITGB3 ITGA2
2
MicroRNAs in cancer 37
12.19 PTGS2 ITGB3 ABCB1
3
Development VEGF signaling via VEGFR2 - generic cascades 22
Show member pathways
 12.04 PTGS2 PTGS1 ITGB3
4
Selenium Micronutrient Network 1
Show member pathways
 11.88 PTGS2 PTGS1 APOB
5
Hematopoietic cell lineage 37
11.59 ITGB3 ITGA2
6
Blood-Brain Barrier Pathway: Anatomy 65
Show member pathways
 11.59 ITGB3 ITGA2 ABCB1
7
Small cell lung cancer 37
11.56 PTGS2 ITGA2
8
Angiogenesis (CST) 4
11.54 PTGS2 ITGB3
9
Phagocytosis of Microbes 64
11.51 ITGB3 ITGA2
10
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.43 PTGS2 ITGB3
11
Platelet activation 37
11.43 PTGS1 ITGB3 ITGA2
12
Celecoxib Pathway, Pharmacodynamics 61
11.33 PTGS2 PTGS1
13
ECM proteoglycans 66
11.31 ITGB3 ITGA2
14
Regulation of lipolysis in adipocytes 37
11.29 PTGS2 PTGS1
15
Cell adhesion_Endothelial cell contacts by non-junctional mechanisms 22
11.14 ITGB3 ITGA2
16
Prostaglandin Synthesis and Regulation 1
10.99 PTGS2 PTGS1
17
Ibuprofen Pathway, Pharmacodynamics 61
10.94 PTGS2 PTGS1
18
HETE and HPETE biosynthesis and metabolism 22
Show member pathways
 10.89 PTGS2 PTGS1
19
Platelet Aggregation Inhibitor Pathway, Pharmacodynamics 61
10.84 PTGS1 ITGB3 ITGA2
20
Eicosanoid Synthesis 1
10.81 PTGS2 PTGS1
21
Prostaglandin 2 biosynthesis and metabolism FM 22
10.77 PTGS2 PTGS1
22
Overview of nanoparticle effects 1
10.6 PTGS2 PTGS1
23
Etoposide Pathway, Pharmacokinetics/Pharmacodynamics 61
9.98 PTGS2 PTGS1 ABCB1
Sources

GO Terms for Aspirin Resistance

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Cellular components related to Aspirin Resistance according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 organelle membrane GO:0031090 8.96 PTGS2 PTGS1
2 integrin complex GO:0008305 8.62 ITGB3 ITGA2

Biological processes related to Aspirin Resistance according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.71 PTGS2 PTGS1 APOB
2 response to drug GO:0042493 9.61 PTGS2 ITGA2 ABCB1
3 wound healing GO:0042060 9.58 ITGB3 ITGA2
4 response to organic substance GO:0010033 9.58 PTGS2 APOB
5 integrin-mediated signaling pathway GO:0007229 9.57 ITGB3 ITGA2
6 cell-matrix adhesion GO:0007160 9.56 ITGB3 ITGA2
7 viral entry into host cell GO:0046718 9.55 ITGB3 ITGA2
8 cellular oxidant detoxification GO:0098869 9.52 PTGS2 PTGS1
9 cellular response to mechanical stimulus GO:0071260 9.51 PTGS2 ITGA2
10 fatty acid biosynthetic process GO:0006633 9.49 PTGS2 PTGS1
11 regulation of blood pressure GO:0008217 9.48 PTGS2 PTGS1
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.46 PTGS2 ITGA2
13 prostaglandin metabolic process GO:0006693 9.4 PTGS2 PTGS1
14 cell adhesion mediated by integrin GO:0033627 9.37 ITGB3 ITGA2
15 positive regulation of smooth muscle contraction GO:0045987 9.32 PTGS2 ITGA2
16 cell-substrate adhesion GO:0031589 9.26 ITGB3 ITGA2
17 prostaglandin biosynthetic process GO:0001516 9.16 PTGS2 PTGS1
18 mesodermal cell differentiation GO:0048333 8.96 ITGB3 ITGA2
19 cyclooxygenase pathway GO:0019371 8.62 PTGS2 PTGS1

Molecular functions related to Aspirin Resistance according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dioxygenase activity GO:0051213 9.26 PTGS2 PTGS1
2 virus receptor activity GO:0001618 9.16 ITGB3 ITGA2
3 peroxidase activity GO:0004601 8.96 PTGS2 PTGS1
4 prostaglandin-endoperoxide synthase activity GO:0004666 8.62 PTGS2 PTGS1
Sources

Sources for Aspirin Resistance

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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