Aliases & Classifications for Asthenopia

MalaCards integrated aliases for Asthenopia:

Name: Asthenopia 12 44 15 73
Accommodative Strain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10141
ICD10 33 H53.14
MeSH 44 D001248
SNOMED-CT 68 46640001 70323002
UMLS 73 C0004095

Summaries for Asthenopia

MalaCards based summary : Asthenopia, also known as accommodative strain, is related to suppression amblyopia and xerophthalmia, and has symptoms including eye manifestations and visual discomfort. An important gene associated with Asthenopia is NCBP1 (Nuclear Cap Binding Protein Subunit 1), and among its related pathways/superpathways is Neuroscience. The drugs Loteprednol and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, heart and cortex, and related phenotype is adipose tissue.

Wikipedia : 76 Eye strain, also known as asthenopia (from Greek asthen-opia, �?�?θεν-�?�?ία, "weak-eye-condition"), is... more...

Related Diseases for Asthenopia

Diseases related to Asthenopia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 suppression amblyopia 10.2 GABBR1 NBL1
2 xerophthalmia 10.2 CADM1 GABBR1
3 facial paralysis 10.1 CADM1 LIPN
4 aniseikonia 10.1
5 headache 10.1
6 facial nerve disease 10.1 CADM1 LIPN
7 paralytic squint 10.1 CADM1 GABBR1 MTRNR2L5
8 premenstrual tension 10.0 LIPN MTRNR2L5
9 torticollis 10.0
10 astigmatism 10.0
11 sinusitis 10.0
12 accommodative spasm 10.0
13 myopia 10.0
14 cortical blindness 10.0
15 monofixation syndrome 10.0
16 disuse amblyopia 9.9 CADM1 SDCBP
17 ametropic amblyopia 9.8 CADM1 GABBR1 MTRNR2L4 MTRNR2L5 SDCBP

Graphical network of the top 20 diseases related to Asthenopia:



Diseases related to Asthenopia

Symptoms & Phenotypes for Asthenopia

UMLS symptoms related to Asthenopia:


eye manifestations, visual discomfort

MGI Mouse Phenotypes related to Asthenopia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.02 ADRB2 GABBR1 LCN2 LGI1 MARK2

Drugs & Therapeutics for Asthenopia

Drugs for Asthenopia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loteprednol Approved, Experimental Phase 4 82034-46-6, 129260-79-3 9865442 444025
2
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
5
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
6
Ofloxacin Approved Phase 4 82419-36-1 4583
7
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
8
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
9 Anti-Allergic Agents Phase 4
10 Ophthalmic Solutions Phase 4
11 Pharmaceutical Solutions Phase 4
12 Anti-Inflammatory Agents Phase 4
13 Lubricant Eye Drops Phase 4
14 Renal Agents Phase 4
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
16 Neuroprotective Agents Phase 4
17 Cathartics Phase 4
18 Cytochrome P-450 Enzyme Inhibitors Phase 4
19 Carboxymethylcellulose Sodium Phase 4
20 Anti-Infective Agents, Urinary Phase 4
21 Laxatives Phase 4
22 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
23 Antineoplastic Agents, Hormonal Phase 4
24 Autonomic Agents Phase 4,Not Applicable
25 Anti-Infective Agents Phase 4
26 Prednisolone acetate Phase 4
27 Protective Agents Phase 4
28 Peripheral Nervous System Agents Phase 4,Not Applicable
29 Topoisomerase Inhibitors Phase 4
30 Antiemetics Phase 4
31 Hormone Antagonists Phase 4
32 Gastrointestinal Agents Phase 4
33 Anti-Bacterial Agents Phase 4
34 glucocorticoids Phase 4
35 Hormones Phase 4
36 Methylprednisolone acetate Phase 4
37 tannic acid Approved Not Applicable
38
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
39
Ethanol Approved Not Applicable 64-17-5 702
40
Caffeine Approved Not Applicable 58-08-2 2519
41
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
42
Methamphetamine Approved, Illicit Not Applicable 537-46-2 10836
43
Metronidazole Approved Not Applicable 443-48-1 4173
44
Melatonin Approved, Nutraceutical, Vet_approved Not Applicable 73-31-4 896
45 Tetrahydrozoline Not Applicable
46 Analgesics Not Applicable
47 Hemostatics
48 Coagulants
49 Fibrin Tissue Adhesive
50 Sympathomimetics Not Applicable

Interventional clinical trials:

(show all 44)
# Name Status NCT ID Phase Drugs
1 The Utility of IVCM to Assess Cellular Response and Efficacy of Long-term Topical Steroid Treatment in Patients With DED Completed NCT02120079 Phase 4 Lotemax;Soothe Tired Eyes Lubricant Eye Drop (Artificial Tears)
2 A Study of Sodium Carboxymethylcellulose for Post Cataract Surgery Dry Eye Symptoms Completed NCT02028754 Phase 4 Sodium Carboxymethylcellulose;Levofloxacin;Prednisolone
3 The Impact of Soft Contact Lens Attributes on Symptoms Associated With Digital Eye Strain in Symptomatic Soft Contact Lens Wearers Not yet recruiting NCT03585790 Phase 4
4 Effects of Optical Blur on Performance and Comfort of Computer Users Unknown status NCT00318045 Phase 3
5 Effects of Different Add Powers on the Comfort and Productivity of Computer Users With Fixed or Free Head Movement Completed NCT00317525 Phase 3
6 Effects of Prismatic Spectacle Lenses on Symptoms of Dizziness, Headache and Anxiety as Caused by Vertical Heterophoria Completed NCT00785135 Phase 3
7 Office-based Vision Therapy for Improving Reading and Attention in Children With Convergence Insufficiency Active, not recruiting NCT02207517 Phase 3
8 Randomized Clinical Trial of Bifocal Lenses Versus Computer-specific Progressive Addition Lenses Terminated NCT00585026 Phase 3
9 Active Prevention of MSDs (Musculoskeletal Disorders, Upper and Spine Members) in the Context of Computer Screen Work Completed NCT02350244 Phase 1
10 Research on Quantification of VR(Virtual Reality) Related Stress and Relaxation Unknown status NCT02986555 Not Applicable
11 The Effect of DA9301 on Tablet Computer-Induced Asthenopia Completed NCT02641470 Not Applicable
12 Accommodative Relief for Uncomfortable Non-Presbyopes Completed NCT03544216 Not Applicable
13 The Effect of 3D Autostereoscopic Video-game Play on the Visual Fatigue in Children Completed NCT02407015 Not Applicable
14 Use of Eye Exercises to Improve Vision Completed NCT03054597 Not Applicable
15 Toric Eye Strain and Stability Study Completed NCT01857102 Not Applicable
16 Visual Discomfort and Reading Completed NCT00402155
17 Connecting Contact Lenses and Digital Technology Completed NCT02921087 Not Applicable
18 The Impact of Lenses on Musculoskeletal and Visual Complaints in VDU Workers With Neck Complaints Completed NCT02656953 Not Applicable
19 Effectiveness of an Eye-Cervical Re-education Program in Chronic Neck Pain Completed NCT03197285 Not Applicable
20 Performance Evaluation of Contact Lenses Among a Population of Adapted Contact Lens Wearers Completed NCT00985231 Not Applicable
21 Clinical Evaluation of Approved and Investigational Contact Lenses Using New UV Additive Completed NCT02982018 Not Applicable
22 Color Perception in Dentistry (CPD) Completed NCT02884856
23 Refraction Determination Analysis Completed NCT01995435 Not Applicable
24 Under-correction in Refractive Accommodative Esotropia Completed NCT01179711 Not Applicable
25 Rotation of an Intraocular Lens - HOYA Vivinex iSert P261 Completed NCT03157375 Not Applicable
26 Treatment of Meibomian Gland Dysfunction and Dry Eye in Contact Lens Wearers Completed NCT02102464 Not Applicable
27 Treatment of Meibomian Gland Dysfunction Prior to Cataract Surgery Completed NCT01808560 Not Applicable
28 A Pilot Clinical Trial of Overminus Spectacle Therapy for Intermittent Exotropia Completed NCT02223650 Not Applicable
29 Dispensing Study for a New Study Test Lens Completed NCT02642991 Not Applicable
30 One Week Assessment of a Lens With a Novel Optical Profile Completed NCT02642354 Not Applicable
31 One Week Assessment of a New Study Test Lens Completed NCT02642341 Not Applicable
32 2D Versus 3D Laparoscopic Training on a Virtual Reality Simulator Completed NCT02361463 Not Applicable
33 Feasibility of IPL for Reducing Dry Eye Symptoms Caused by MGD Completed NCT02621593 Not Applicable
34 Assessment of Low-temperature Plasma Surgery System in Pterygium With Fibrin Glue and Conjunctival Autografts Completed NCT03204084
35 Influence of Daily Activities on Retinal Microcirculation Recruiting NCT03416088 Not Applicable
36 Neural Mechanism of Vision Therapy for Patients With Convergence Insufficiency Recruiting NCT03593031 Not Applicable
37 To Compare the Effectiveness of 3 Different Types of Lens and Lens Coating in Eliminating Symptoms for Children With Prolonged Visual Symptoms Due to a Concussion. Recruiting NCT03123822 Not Applicable
38 Feasibility Pilot of Bright Light in the Intensive Care Unit Recruiting NCT03568045 Not Applicable
39 Laparoscopic Appendectomy Performed by Junior SUrgeonS: Impact of 3D Visualization on Surgical Outcome Recruiting NCT03770897 Not Applicable
40 Trial of Overminus Spectacle Therapy for Intermittent Exotropia Recruiting NCT02807350 Not Applicable
41 Testing the Effectiveness of an Evening Blue-depleted Light Environment in an Acute Psychiatric Ward Recruiting NCT03788993 Not Applicable
42 Light Intervention for Adaptation to Night Work Enrolling by invitation NCT03203538 Not Applicable
43 Daytime Bright Light, Circadian Abnormalities, and Delirium in Medical ICU Patients Not yet recruiting NCT03684460 Not Applicable
44 Effects of Gunnar Computer Glasses on Viewing Comfort and Performance Terminated NCT02925884 Not Applicable

Search NIH Clinical Center for Asthenopia

Cochrane evidence based reviews: asthenopia

Genetic Tests for Asthenopia

Anatomical Context for Asthenopia

MalaCards organs/tissues related to Asthenopia:

41
Eye, Heart, Cortex

Publications for Asthenopia

Articles related to Asthenopia:

(show top 50) (show all 85)
# Title Authors Year
1
Fruit and vegetable consumption and its relation to risk of asthenopia among Chinese college students. ( 29977818 )
2018
2
Evaluation of binocular function among pre- and early-presbyopes with asthenopia. ( 30214336 )
2018
3
Correlation between handheld digital device use and asthenopia in Chinese college students: a Shanghai study. ( 30272832 )
2018
4
Role of short-wavelength filtering lenses in delaying myopia progression and amelioration of asthenopia in juveniles. ( 28861353 )
2017
5
The effect of Vaccinium uliginosum extract on tablet computer-induced asthenopia: randomized placebo-controlled study. ( 27538497 )
2016
6
Prevalence of asthenopia in children: a systematic review with meta-analysis. ( 25986614 )
2015
7
Asthenopia, Associated Phoria, and Self-Selected Prism. ( 26158471 )
2015
8
A Pilot Study: Warm Stimulation on Guangming (GB37) to Relief Asthenopia. ( 26064168 )
2015
9
Asthenopia in schoolchildren. ( 26357460 )
2015
10
Dante and asthenopia: a modern visual problem described during the Middle Ages. ( 24406403 )
2014
11
Clinical evaluation of accommodation and ocular surface stability relevant to visual asthenopia with 3D displays. ( 24612686 )
2014
12
3D asthenopia in horizontal deviation. ( 23406011 )
2013
13
Prevalence of asthenopia and its risk factors in Chinese college students. ( 24195055 )
2013
14
An experimental study of the protective effects of Chinese medicine compound eye-patch on asthenopia. ( 23371460 )
2013
15
Clinical research on the ophthalmic factors affecting 3D asthenopia. ( 22329550 )
2012
16
Effects of job-related stress and burnout on asthenopia among high-tech workers. ( 22676548 )
2012
17
Asthenopia as the presenting symptom in advance allergic fungal sinusitis. ( 23961016 )
2012
18
Potential preventive effects of a new visual intervention for accommodative insufficiency and asthenopia due to sustained near task. ( 22261636 )
2012
19
Ophthalmological factors influencing visual asthenopia as a result of viewing 3D displays. ( 22952400 )
2012
20
Asthenopia and blink rate under visual and cognitive loads. ( 22051780 )
2012
21
Chromatic aberration, accommodation, and color preference in asthenopia. ( 22733104 )
2012
22
Asthenopia (eyestrain) in working children of gem-polishing industries. ( 20940266 )
2011
23
Effects of dietary supplementation with a combination of fish oil, bilberry extract, and lutein on subjective symptoms of asthenopia in humans. ( 22199129 )
2011
24
Prevention of scattered light-induced asthenopia and fatigue by a polarized filter. ( 20415740 )
2010
25
Orthoptic findings and asthenopia in a population of Swedish schoolchildren aged 6 to 16 years. ( 18484506 )
2008
26
A community-based study of asthenopia in computer operators. ( 18158404 )
2008
27
Eyelid squint response to asthenopia-inducing conditions. ( 17632310 )
2007
28
Association between occupational asthenopia and psycho-physiological indicators of visual strain in workers using video display terminals. ( 16819428 )
2006
29
Asthenopia in schoolchildren, orthoptic and ophthalmological findings and treatment. ( 16514487 )
2005
30
Reduction of asthenopia related to accommodative relaxation by means of far point stimuli. ( 15715563 )
2005
31
A novel in vitro model for screening and evaluation of anti-asthenopia drugs. ( 14578593 )
2003
32
An attempt at preventing asthenopia among VDT workers. ( 14675518 )
2003
33
Is all asthenopia the same? ( 14627938 )
2003
34
Effect of subjective and objective workload on asthenopia at VDU workplaces. ( 14675517 )
2003
35
Muscular asthenopia and eccentric ablation after photorefractive keratectomy. ( 11383768 )
2001
36
Accommodative microfluctuation in asthenopia caused by accommodative spasm. ( 11764414 )
2001
37
Effect of cumulative nearwork on accommodative facility and asthenopia. ( 12678397 )
2001
38
Post-PRK muscular asthenopia and eccentric ablation. ( 11780199 )
2001
39
An unusual cause of asthenopia: "pseudo-accommodative insufficiency" associated with a high AC:A ratio. ( 11186867 )
2000
40
Bilateral striate cortex contusion presenting with cerebral asthenopia rather than cortical blindness. ( 9267074 )
1997
41
Refractive aniseikonia: a source of binocular vision stress and asthenopia. ( 8871853 )
1996
42
Protective filters in the prevention of asthenopia at a video display terminal. ( 7624210 )
1995
43
Asthenopia and the dark focus of accommodation. ( 8090440 )
1994
44
Is the type of VDT work important in asthenopia? ( 8485397 )
1993
45
Asthenopia: frequency and objective findings. ( 1477627 )
1992
46
Asthenopia induced by computer-generated fusional vergence targets. ( 1437013 )
1992
47
Duane's retraction syndrome and the relief of secondary torticollis and near point asthenopia with prism. ( 2380474 )
1990
48
Reduction of asthenopia after accommodative facility training. ( 3631199 )
1987
49
Soft bifocal contact lenses for patients with nearpoint asthenopia. ( 4078211 )
1985
50
Reduction of asthenopia in patients with convergence insufficiency after fusional vergence training. ( 6660282 )
1983

Variations for Asthenopia

Expression for Asthenopia

Search GEO for disease gene expression data for Asthenopia.

Pathways for Asthenopia

Pathways related to Asthenopia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 ADRB2 GABBR1 MARK2 NGF

GO Terms for Asthenopia

Cellular components related to Asthenopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.46 GABBR1 MARK2 NGF PI4K2A
2 cell junction GO:0030054 9.35 CADM1 GABBR1 LGI1 PI4K2A SDCBP
3 extracellular region GO:0005576 9.28 GABBR1 LCN2 LGI1 LIPN MTRNR2L4 MTRNR2L5

Biological processes related to Asthenopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular negative regulation of signal transduction GO:1900116 9.16 MTRNR2L4 MTRNR2L5
2 negative regulation of execution phase of apoptosis GO:1900118 8.96 MTRNR2L4 MTRNR2L5
3 positive regulation of cell growth GO:0030307 8.8 LGI1 NCBP1 SDCBP

Molecular functions related to Asthenopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.35 ADRB2 CADM1 LCN2 NBL1 SDCBP
2 receptor antagonist activity GO:0048019 8.62 MTRNR2L4 MTRNR2L5

Sources for Asthenopia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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