Aliases & Classifications for Asthenopia

MalaCards integrated aliases for Asthenopia:

Name: Asthenopia 12 44 15 73
Accommodative Strain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10141
ICD10 33 H53.14
MeSH 44 D001248
UMLS 73 C0004095

Summaries for Asthenopia

MalaCards based summary : Asthenopia, also known as accommodative strain, is related to suppression amblyopia and facial paralysis, and has symptoms including eye manifestations and visual discomfort. An important gene associated with Asthenopia is NCBP1 (Nuclear Cap Binding Protein Subunit 1), and among its related pathways/superpathways is Neuroscience. The drugs Loteprednol and Levofloxacin have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and cortex, and related phenotype is adipose tissue.

Related Diseases for Asthenopia

Diseases related to Asthenopia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 suppression amblyopia 10.5 GABBR1 NBL1
2 facial paralysis 10.4 CADM1 LIPN
3 facial nerve disease 10.3 CADM1 LIPN
4 paralytic squint 10.1 CADM1 GABBR1 MTRNR2L5
5 premenstrual tension 10.1 LIPN MTRNR2L5
6 aging 10.0
7 aniseikonia 10.0
8 cerebritis 10.0
9 torticollis 9.8
10 astigmatism 9.8
11 sinusitis 9.8
12 accommodative spasm 9.8
13 myopia 9.8
14 cortical blindness 9.8
15 monofixation syndrome 9.8
16 disuse amblyopia 9.8 CADM1 SDCBP
17 ametropic amblyopia 9.2 CADM1 GABBR1 MTRNR2L4 MTRNR2L5 SDCBP

Graphical network of the top 20 diseases related to Asthenopia:



Diseases related to Asthenopia

Symptoms & Phenotypes for Asthenopia

UMLS symptoms related to Asthenopia:


eye manifestations, visual discomfort

MGI Mouse Phenotypes related to Asthenopia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.02 ADRB2 GABBR1 LCN2 LGI1 MARK2

Drugs & Therapeutics for Asthenopia

Drugs for Asthenopia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loteprednol Approved Phase 4 82034-46-6, 129260-79-3 444025 9865442
2
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Ofloxacin Approved Phase 4 82419-36-1 4583
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
6 Anti-Allergic Agents Phase 4
7 Anti-Inflammatory Agents Phase 4
8 Lubricant Eye Drops Phase 4
9 Ophthalmic Solutions Phase 4
10 Pharmaceutical Solutions Phase 4
11 Tetrahydrozoline Phase 4,Not Applicable
12 Anti-Bacterial Agents Phase 4
13 Antiemetics Phase 4
14 Anti-Infective Agents Phase 4
15 Antineoplastic Agents, Hormonal Phase 4
16 Autonomic Agents Phase 4,Not Applicable
17 Carboxymethylcellulose Sodium Phase 4
18 Cathartics Phase 4
19 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
20 Cytochrome P-450 Enzyme Inhibitors Phase 4
21 Gastrointestinal Agents Phase 4
22 glucocorticoids Phase 4
23 Hormone Antagonists Phase 4
24 Hormones Phase 4
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
26 Laxatives Phase 4
27 Methylprednisolone acetate Phase 4
28 Methylprednisolone Hemisuccinate Phase 4
29 Neuroprotective Agents Phase 4
30 Peripheral Nervous System Agents Phase 4,Not Applicable
31 Prednisolone acetate Phase 4
32 Prednisolone hemisuccinate Phase 4
33 Prednisolone phosphate Phase 4
34 Protective Agents Phase 4
35 Renal Agents Phase 4
36 Topoisomerase Inhibitors Phase 4
37
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
38
Ethanol Approved Not Applicable 64-17-5 702
39
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
40
Methamphetamine Approved, Illicit Not Applicable 537-46-2 10836
41 tannic acid Approved, Nutraceutical Not Applicable
42
Caffeine Approved, Nutraceutical Not Applicable 58-08-2 2519
43
Melatonin Approved, Nutraceutical, Vet_approved Not Applicable 73-31-4 896
44 Analgesics Not Applicable
45 Coagulants
46 Fibrin Tissue Adhesive
47 Hemostatics
48 Adrenergic Agents Not Applicable
49 Central Nervous System Stimulants Not Applicable
50 Dopamine Agents Not Applicable

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 The Utility of IVCM to Assess Cellular Response and Efficacy of Long-term Topical Steroid Treatment in Patients With DED Completed NCT02120079 Phase 4 Lotemax;Soothe Tired Eyes Lubricant Eye Drop (Artificial Tears)
2 A Study of Sodium Carboxymethylcellulose for Post Cataract Surgery Dry Eye Symptoms Completed NCT02028754 Phase 4 Sodium Carboxymethylcellulose;Levofloxacin;Prednisolone
3 Effects of Optical Blur on Performance and Comfort of Computer Users Unknown status NCT00318045 Phase 3
4 Effects of Different Add Powers on the Comfort and Productivity of Computer Users With Fixed or Free Head Movement Completed NCT00317525 Phase 3
5 Effects of Prismatic Spectacle Lenses on Symptoms of Dizziness, Headache and Anxiety as Caused by Vertical Heterophoria Completed NCT00785135 Phase 3
6 Office-based Vision Therapy for Improving Reading and Attention in Children With Convergence Insufficiency Active, not recruiting NCT02207517 Phase 3
7 Randomized Clinical Trial of Bifocal Lenses Versus Computer-specific Progressive Addition Lenses Terminated NCT00585026 Phase 3
8 Active Prevention of MSDs (Musculoskeletal Disorders, Upper and Spine Members) in the Context of Computer Screen Work Completed NCT02350244 Phase 1
9 2D Versus 3D Laparoscopic Training on a Virtual Reality Simulator Unknown status NCT02361463 Not Applicable
10 The Effect of DA9301 on Tablet Computer-Induced Asthenopia Completed NCT02641470 Not Applicable
11 Accommodative Relief for Uncomfortable Non-Presbyopes Completed NCT03544216 Not Applicable
12 The Effect of 3D Autostereoscopic Video-game Play on the Visual Fatigue in Children Completed NCT02407015 Not Applicable
13 Use of Eye Exercises to Improve Vision Completed NCT03054597 Not Applicable
14 Toric Eye Strain and Stability Study Completed NCT01857102 Not Applicable
15 Visual Discomfort and Reading Completed NCT00402155
16 Connecting Contact Lenses and Digital Technology Completed NCT02921087 Not Applicable
17 The Impact of Lenses on Musculoskeletal and Visual Complaints in VDU Workers With Neck Complaints Completed NCT02656953 Not Applicable
18 Effectiveness of an Eye-Cervical Re-education Program in Chronic Neck Pain Completed NCT03197285 Not Applicable
19 Performance Evaluation of Contact Lenses Among a Population of Adapted Contact Lens Wearers Completed NCT00985231 Not Applicable
20 Color Perception in Dentistry (CPD) Completed NCT02884856
21 Refraction Determination Analysis Completed NCT01995435 Not Applicable
22 Under-correction in Refractive Accommodative Esotropia Completed NCT01179711 Not Applicable
23 Rotation of an Intraocular Lens - HOYA Vivinex iSert P261 Completed NCT03157375 Not Applicable
24 Treatment of Meibomian Gland Dysfunction and Dry Eye in Contact Lens Wearers Completed NCT02102464 Not Applicable
25 Treatment of Meibomian Gland Dysfunction Prior to Cataract Surgery Completed NCT01808560 Not Applicable
26 A Pilot Clinical Trial of Overminus Spectacle Therapy for Intermittent Exotropia Completed NCT02223650 Not Applicable
27 Dispensing Study for a New Study Test Lens Completed NCT02642991 Not Applicable
28 One Week Assessment of a Lens With a Novel Optical Profile Completed NCT02642354 Not Applicable
29 One Week Assessment of a New Study Test Lens Completed NCT02642341 Not Applicable
30 Feasibility of IPL for Reducing Dry Eye Symptoms Caused by MGD Completed NCT02621593 Not Applicable
31 Assessment of Low-temperature Plasma Surgery System in Pterygium With Fibrin Glue and Conjunctival Autografts Completed NCT03204084
32 Research on Quantification of VR(Virtual Reality) Related Stress and Relaxation Recruiting NCT02986555 Not Applicable
33 Influence of Daily Activities on Retinal Microcirculation Recruiting NCT03416088 Not Applicable
34 To Compare the Effectiveness of 3 Different Types of Lens and Lens Coating in Eliminating Symptoms for Children With Prolonged Visual Symptoms Due to a Concussion. Recruiting NCT03123822 Not Applicable
35 Trial of Overminus Spectacle Therapy for Intermittent Exotropia Recruiting NCT02807350 Not Applicable
36 Light Intervention for Adaptation to Night Work Enrolling by invitation NCT03203538 Not Applicable
37 Feasibility Pilot of Bright Light in the Intensive Care Unit Not yet recruiting NCT03568045 Not Applicable
38 Effects of Gunnar Computer Glasses on Viewing Comfort and Performance Terminated NCT02925884 Not Applicable

Search NIH Clinical Center for Asthenopia

Cochrane evidence based reviews: asthenopia

Genetic Tests for Asthenopia

Anatomical Context for Asthenopia

MalaCards organs/tissues related to Asthenopia:

41
Eye, Testes, Cortex

Publications for Asthenopia

Articles related to Asthenopia:

(show top 50) (show all 73)
# Title Authors Year
1
Fruit and vegetable consumption and its relation to risk of asthenopia among Chinese college students. ( 29977818 )
2018
2
Role of short-wavelength filtering lenses in delaying myopia progression and amelioration of asthenopia in juveniles. ( 28861353 )
2017
3
The effect of Vaccinium uliginosum extract on tablet computer-induced asthenopia: randomized placebo-controlled study. ( 27538497 )
2016
4
Prevalence of asthenopia in children: a systematic review with meta-analysis. ( 25986614 )
2015
5
Asthenopia, Associated Phoria, and Self-Selected Prism. ( 26158471 )
2015
6
A Pilot Study: Warm Stimulation on Guangming (GB37) to Relief Asthenopia. ( 26064168 )
2015
7
Asthenopia in schoolchildren. ( 26357460 )
2015
8
Dante and asthenopia: a modern visual problem described during the Middle Ages. ( 24406403 )
2014
9
Clinical evaluation of accommodation and ocular surface stability relevant to visual asthenopia with 3D displays. ( 24612686 )
2014
10
3D asthenopia in horizontal deviation. ( 23406011 )
2013
11
Prevalence of asthenopia and its risk factors in Chinese college students. ( 24195055 )
2013
12
An experimental study of the protective effects of Chinese medicine compound eye-patch on asthenopia. ( 23371460 )
2013
13
Clinical research on the ophthalmic factors affecting 3D asthenopia. ( 22329550 )
2012
14
Effects of job-related stress and burnout on asthenopia among high-tech workers. ( 22676548 )
2012
15
Asthenopia as the presenting symptom in advance allergic fungal sinusitis. ( 23961016 )
2012
16
Potential preventive effects of a new visual intervention for accommodative insufficiency and asthenopia due to sustained near task. ( 22261636 )
2012
17
Ophthalmological factors influencing visual asthenopia as a result of viewing 3D displays. ( 22952400 )
2012
18
Asthenopia and blink rate under visual and cognitive loads. ( 22051780 )
2012
19
Chromatic aberration, accommodation, and color preference in asthenopia. ( 22733104 )
2012
20
Asthenopia (eyestrain) in working children of gem-polishing industries. ( 20940266 )
2011
21
Effects of dietary supplementation with a combination of fish oil, bilberry extract, and lutein on subjective symptoms of asthenopia in humans. ( 22199129 )
2011
22
Prevention of scattered light-induced asthenopia and fatigue by a polarized filter. ( 20415740 )
2010
23
Orthoptic findings and asthenopia in a population of Swedish schoolchildren aged 6 to 16 years. ( 18484506 )
2008
24
A community-based study of asthenopia in computer operators. ( 18158404 )
2008
25
Eyelid squint response to asthenopia-inducing conditions. ( 17632310 )
2007
26
Association between occupational asthenopia and psycho-physiological indicators of visual strain in workers using video display terminals. ( 16819428 )
2006
27
Asthenopia in schoolchildren, orthoptic and ophthalmological findings and treatment. ( 16514487 )
2005
28
Reduction of asthenopia related to accommodative relaxation by means of far point stimuli. ( 15715563 )
2005
29
A novel in vitro model for screening and evaluation of anti-asthenopia drugs. ( 14578593 )
2003
30
An attempt at preventing asthenopia among VDT workers. ( 14675518 )
2003
31
Is all asthenopia the same? ( 14627938 )
2003
32
Effect of subjective and objective workload on asthenopia at VDU workplaces. ( 14675517 )
2003
33
Muscular asthenopia and eccentric ablation after photorefractive keratectomy. ( 11383768 )
2001
34
Accommodative microfluctuation in asthenopia caused by accommodative spasm. ( 11764414 )
2001
35
Effect of cumulative nearwork on accommodative facility and asthenopia. ( 12678397 )
2001
36
Post-PRK muscular asthenopia and eccentric ablation. ( 11780199 )
2001
37
An unusual cause of asthenopia: "pseudo-accommodative insufficiency" associated with a high AC:A ratio. ( 11186867 )
2000
38
Bilateral striate cortex contusion presenting with cerebral asthenopia rather than cortical blindness. ( 9267074 )
1997
39
Refractive aniseikonia: a source of binocular vision stress and asthenopia. ( 8871853 )
1996
40
Protective filters in the prevention of asthenopia at a video display terminal. ( 7624210 )
1995
41
Asthenopia and the dark focus of accommodation. ( 8090440 )
1994
42
Is the type of VDT work important in asthenopia? ( 8485397 )
1993
43
Asthenopia: frequency and objective findings. ( 1477627 )
1992
44
Asthenopia induced by computer-generated fusional vergence targets. ( 1437013 )
1992
45
Duane's retraction syndrome and the relief of secondary torticollis and near point asthenopia with prism. ( 2380474 )
1990
46
Reduction of asthenopia after accommodative facility training. ( 3631199 )
1987
47
Soft bifocal contact lenses for patients with nearpoint asthenopia. ( 4078211 )
1985
48
Reduction of asthenopia in patients with convergence insufficiency after fusional vergence training. ( 6660282 )
1983
49
Asynchronous cortical input and asthenopia. ( 7124897 )
1982
50
Adaptation to prism-induced heterophoria in subjects with abnormal binocular vision or asthenopia. ( 7294146 )
1981

Variations for Asthenopia

Expression for Asthenopia

Search GEO for disease gene expression data for Asthenopia.

Pathways for Asthenopia

Pathways related to Asthenopia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 ADRB2 GABBR1 MARK2 NGF

GO Terms for Asthenopia

Cellular components related to Asthenopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.28 GABBR1 LCN2 LGI1 LIPN MTRNR2L4 MTRNR2L5

Biological processes related to Asthenopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell growth GO:0030307 8.8 LGI1 NCBP1 SDCBP

Sources for Asthenopia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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