MCID: AST005
MIFTS: 82

Asthma

Categories: Genetic diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Asthma

MalaCards integrated aliases for Asthma:

Name: Asthma 57 38 12 76 53 75 75 37 29 55 6 43 3 44 15 63 63 73
Asthma, Susceptibility to 57 29 6 40
Asthma, Diminished Response to Antileukotriene Treatment in 57 13 6
Chronic Obstructive Asthma 12 55 73
Bronchial Hyperreactivity 12 55 73
Asthma, Nocturnal, Susceptibility to 57 6
Asthma, Protection Against 57 6
Chronic Obstructive Asthma with Acute Exacerbation 12
Chronic Obstructive Asthma with Status Asthmaticus 12
Asthma-Related Traits, Susceptibility to 57
Asthma, Exercise-Induced 73
Exercise Induced Asthma 12
Exercise-Induced Asthma 12
Asthma Exercise-Induced 55
Asthma-Related Traits 57
Asthma, Bronchial 57
Asthma, Nocturnal 57
Bronchial Asthma 75

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant vs. multifactorial


Classifications:



Summaries for Asthma

MedlinePlus : 43 Asthma is a chronic disease that affects your airways. Your airways are tubes that carry air in and out of your lungs. If you have asthma, the inside walls of your airways become sore and swollen. That makes them very sensitive, and they may react strongly to things that you are allergic to or find irritating. When your airways react, they get narrower and your lungs get less air. Symptoms of asthma include Wheezing Coughing, especially early in the morning or at night Chest tightness Shortness of breath Not all people who have asthma have these symptoms. Having these symptoms doesn't always mean that you have asthma. Your doctor will diagnose asthma based on lung function tests, your medical history, and a physical exam. You may also have allergy tests. When your asthma symptoms become worse than usual, it's called an asthma attack. Severe asthma attacks may require emergency care, and they can be fatal. Asthma is treated with two kinds of medicines: quick-relief medicines to stop asthma symptoms and long-term control medicines to prevent symptoms. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Asthma, also known as asthma, susceptibility to, is related to allergic asthma and cough variant asthma, and has symptoms including recurring periods of wheezing (a whistling sound while breathing), chest tightness and shortness of breath. An important gene associated with Asthma is ADRB2 (Adrenoceptor Beta 2), and among its related pathways/superpathways are Asthma and Allograft rejection. The drugs Accolate and Advair have been mentioned in the context of this disorder. Affiliated tissues include Lung, lung and testes, and related phenotypes are asthma and immune system

Disease Ontology : 12 A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has symptom recurring periods of wheezing (a whistling sound while breathing), has symptom chest tightness, has symptom shortness of breath, has symptom mucus production and has symptom coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

NIH Rare Diseases : 53 Asthma is a breathing disorder that affects the airways. People with this condition experience recurrent swelling and narrowing of the airways of the lungs which is associated with wheezing, shortness of breath, chest tightness, and coughing. Most affected people have episodes of symptoms ("asthma attacks") followed by symptom-free periods; however, some may experience persistent shortness of breath in between attacks. Asthma is considered a complex or multifactorial condition that is likely due to a combination of multiple genetic, environmental, and lifestyle factors. Many people with asthma have a personal or family history of allergies, such as hay fever or eczema. Having a family member with asthma is associated with an increased risk of developing the condition. Treatment generally includes various medications, both to prevent asthma attacks and to provide quick relief during an attack.

OMIM : 57 Bronchial asthma is the most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, and dyspnea; bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test; serum IgE levels; atopy; and atopic dermatitis (Laitinen et al., 2001; Illig and Wjst, 2002; Pillai et al., 2006). See 147050 for information on the asthma-associated phenotype atopy. (600807)

CDC : 3 Asthma is a disease that affects your lungs. It causes repeated episodes of wheezing, breathlessness, chest tightness, and nighttime or early morning coughing. Asthma can be controlled by taking medicine and avoiding the triggers that can cause an attack. You must also remove the triggers in your environment that can make your asthma worse.

Novus Biologicals : 56 Asthma is a chronic lung disease that causes inflammation, thickening and narrowing of airways, as well as an overproduction of mucus. More than 300 million people worldwide suffer from asthma. Asthma symptoms include wheezing, shortness of breath, coughing and tightness of the chest. Interleukin 13 (IL-13) is the key effector cytokine in asthma. IL-13 stimulates airway fibrosis via action of matrix metalloproteinases (MMPs) on tumor transforming growth factor beta (TGN-beta), and also promotes epithelial damage, mucus production and an increased concentration of eosinophils. The inflammatory response characteristic of asthma is augmented by the production of IL-13 and other TH2 cytokines.

UniProtKB/Swiss-Prot : 75 Asthma: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.

PubMed Health : 63 About asthma: Asthma (AZ-ma) is a chronic (long-term) lung disease that inflames and narrows the airways. Asthma causes recurring periods of wheezing (a whistling sound when you breathe), chest tightness, shortness of breath, and coughing. The coughing often occurs at night or early in the morning.Asthma affects people of all ages, but it most often starts during childhood. In the United States, more than 25 million people are known to have asthma. About 7 million of these people are children.

Wikipedia : 76 Asthma is a common long-term inflammatory disease of the airways of the lungs. It is characterized by... more...

Related Diseases for Asthma

Diseases related to Asthma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 479)
# Related Disease Score Top Affiliating Genes
1 allergic asthma 36.6 CCL11 IL13 IL5 NPSR1 RNASE3
2 cough variant asthma 35.4 IL5 RNASE3
3 intrinsic asthma 35.4 IL5 RNASE3
4 ige responsiveness, atopic 35.2 ADRB2 IL13 IL5 PHF11 PLA2G7 RNASE3
5 status asthmaticus 35.0 ADRB2 IL5 RNASE3
6 allergic rhinitis 34.8 ALOX5 CCL11 IL13 IL5 RNASE3
7 dermatitis 34.6 CCL11 IL13 IL5 NPSR1 PHF11 RNASE3
8 dermatitis, atopic 34.5 CCL11 IL13 IL5 PHF11 RNASE3 TNF
9 pollen allergy 34.2 ADRB2 IL13 IL5 RNASE3
10 chronic eosinophilic pneumonia 34.1 CCL11 IL5 RNASE3
11 churg-strauss syndrome 34.0 IL5 RNASE3 TNF
12 latex allergy 34.0 IL13 IL5 RNASE3
13 esophagitis, eosinophilic, 1 34.0 CCL11 IL13 IL5
14 rhinitis 33.8 CCL11 CYSLTR1 IL13 IL5 RNASE3
15 allergic hypersensitivity disease 33.7 CCL11 IL13 IL5 RNASE3
16 pulmonary disease, chronic obstructive 33.4 ADRB2 CCL11 IL13 RNASE3 TNF
17 immune system disease 33.3 IL13 IL5 TNF
18 bronchiolitis 33.1 CCL11 IL13 IL5 RNASE3 TNF
19 bronchitis 33.1 CCL11 IL5 RNASE3 TNF
20 pneumonia 32.8 CCL11 IL13 IL5 TNF
21 pulmonary eosinophilia 32.7 CCL11 IL13 IL5 RNASE3
22 common cold 32.5 CCL11 IL13 IL5 RNASE3
23 food allergy 32.5 IL13 IL5 RNASE3
24 sinusitis 32.5 CYSLTR1 IL5 RNASE3
25 eosinophilic pneumonia 32.4 CCL11 IL13 IL5 RNASE3
26 conjunctivitis 32.4 CCL11 IL13 IL5 RNASE3
27 hypereosinophilic syndrome 32.2 CCL11 IL13 IL5 RNASE3
28 gastroenteritis 32.2 CCL11 IL5 RNASE3 TNF
29 allergic conjunctivitis 32.2 CCL11 IL13 IL5 RNASE3
30 bronchial disease 32.1 ADRB2 ALOX5 CCL11 CYSLTR1 IL13 IL5
31 eosinophilic gastroenteritis 32.1 CCL11 IL5 RNASE3
32 keratoconjunctivitis 32.1 CCL11 IL13 IL5 RNASE3 TNF
33 otitis media 32.0 CCL11 RNASE3 TNF
34 schistosomiasis 32.0 IL13 IL5 RNASE3 TNF
35 esophagitis 32.0 CCL11 IL13 IL5
36 vernal keratoconjunctivitis 32.0 CCL11 IL13 IL5 RNASE3
37 inflammatory bowel disease 32.0 ALOX5 CCL11 IL13 IL5 NPSR1 TNF
38 strongyloidiasis 31.9 CCL11 IL13 IL5
39 respiratory syncytial virus infectious disease 31.9 IL13 IL5
40 chronic conjunctivitis 31.7 CCL11 IL13 IL5 RNASE3
41 paranasal sinus disease 31.5 ALOX5 IL13 IL5
42 ascaris lumbricoides infection 30.4 IL13 IL5
43 asthma, nasal polyps, and aspirin intolerance 12.5
44 asthma-related traits 1 12.4
45 asthma-related traits 2 12.4
46 asthma-related traits 4 12.3
47 asthma-related traits 5 12.3
48 asthma-related traits 7 12.3
49 asthma-related traits 3 12.1
50 asthma-related traits 6 12.1

Comorbidity relations with Asthma via Phenotypic Disease Network (PDN):


Acute Cystitis Bronchitis
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Osteoporosis
Respiratory Failure Status Asthmaticus

Graphical network of the top 20 diseases related to Asthma:



Diseases related to Asthma

Symptoms & Phenotypes for Asthma

Symptoms via clinical synopsis from OMIM:

57
Resp:
asthma
airway hyperresponsiveness


Clinical features from OMIM:

600807

Symptoms:

12
  • recurring periods of wheezing (a whistling sound while breathing)
  • chest tightness
  • shortness of breath
  • mucus production
  • coughing

Human phenotypes related to Asthma:

32
# Description HPO Frequency HPO Source Accession
1 asthma 32 HP:0002099

UMLS symptoms related to Asthma:


coughing, cyanosis, dyspnea, sneezing, snoring, spasm, wheezing, expiratory wheeze, labored breathing

MGI Mouse Phenotypes related to Asthma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.7 ADRB2 ALOX5 CCL11 CYSLTR1 HLA-G IL13
2 respiratory system MP:0005388 9.17 CCL11 CYSLTR1 IL13 IL5 NPSR1 PHF11

Drugs & Therapeutics for Asthma

PubMedHealth treatment related to Asthma: 63

Asthma is a long-term disease that has no cure. The goal of asthma treatment is to control the disease. Good asthma control will:Prevent chronic and troublesome symptoms, such as coughing and shortness of breathReduce your need for quick-relief medicines (see below)Help you maintain good lung functionLet you maintain your normal activity level and sleep through the nightPrevent asthma attacks that could result in an emergency room visit or hospital stayTo control asthma, partner with your doctor to manage your asthma or your child's asthma. Children aged 10 or older—and younger children who are able—should take an active role in their asthma care.Taking an active role to control your asthma involves:Working with your doctor to treat other conditions that can interfere with asthma management.Avoiding things that worsen your asthma (asthma triggers). However, one trigger you should not avoid is physical activity. Physical activity is an important part of a healthy lifestyle. Talk with your doctor about medicines that can help you stay active.Working with your doctor and other health care providers to create and follow an asthma action plan.An asthma action plan gives guidance on taking your medicines properly, avoiding asthma triggers (except physical activity), tracking your level of asthma control, responding to worsening symptoms, and seeking emergency care when needed.Asthma is treated with two types of medicines: long-term control and quick-relief medicines. Long-term control medicines help reduce airway inflammation and prevent asthma symptoms. Quick-relief, or "rescue," medicines relieve asthma symptoms that may flare up.Your initial treatment will depend on the severity of your asthma. Followup asthma treatment will depend on how well your asthma action plan is controlling your symptoms and preventing asthma attacks.Your level of asthma control can vary over time and with changes in your home, school, or work environments. These changes can alter how often you're exposed to the factors that can worsen your asthma.Your doctor may need to increase your medicine if your asthma doesn't stay under control. On the other hand, if your asthma is well controlled for several months, your doctor may decrease your medicine. These adjustments to your medicine will help you maintain the best control possible with the least amount of medicine necessary.Asthma treatment for certain groups of people—such as children, pregnant women, or those for whom exercise brings on asthma symptoms—will be adjusted to meet their special needs.

FDA approved drugs:

(show all 16)
# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Accolate 18 ZAFIRLUKAST AstraZeneca September 1999|October 1996
2
Advair 18 FLUTICASONE PROPIONATE; SALMETEROL XINAFOATE GlaxoSmithKline August 2000
3
Alvesco 18 CICLESONIDE Nycomed January 2008
4
Arnuity Ellipta 18 FLUTICASONE FUROATE GlaxoSmithKline August 2014
5
Azmacort 18 TRIAMCINOLONE ACETONIDE Rhone Poulenc Rorer November 1996
6
Dulera 18 FORMOTEROL FUMARATE; MOMETASONE FUROATE Merck June 2010
7
Flovent Rotadisk 18 FLUTICASONE PROPIONATE GlaxoSmithKline November 1997
8
Foradil Aerolizer 18 FORMOTEROL FUMARATE Novartis February 2001 (asthma, bronchospasm); September 2001 (COPD)
9
Metaprotereol Sulfate 18 METAPROTERENOL SULFATE Morton Grove Pharmaceuticals March 1997
10
Nucala 18 MEPOLIZUMAB GlaxoSmithKline November 2015
11
Qvar 18 BECLOMETHASONE DIPROPIONATE Ivax May 2002
12
Rayos 18 PREDNISONE Horizon Pharma July of 2012
13
Serevent 18 SALMETEROL XINAFOATE GlaxoSmithKline September 1997
14
Singulair 18 MONTELUKAST SODIUM Merck February 1998
15
Xolair 18 OMALIZUMAB Genentech June 2003
16
Zyflo 18 ZILEUTON Abbott Laboratories January 1997

Drugs for Asthma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1110)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Budesonide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 51333-22-3 63006 5281004
2
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 10102-43-9 145068 160954
3
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
4
Fluticasone Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 90566-53-3 62924
5
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 299-42-3 9294
6
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 93-14-1 3516
7
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 90-82-4 7028
8
Ipratropium Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 22254-24-6, 60205-81-4 43232
9
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7487-88-9 24083
10
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 83-43-2 6741
11
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-24-8 5755
12
Montelukast Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 158966-92-8 5281040
13
Procaterol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 72332-33-3 688561
14
Atracurium Approved, Experimental, Investigational Phase 4,Phase 2,Phase 3,Phase 1 64228-79-1 47319
15
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
16
Cisatracurium Approved Phase 4 96946-41-7
17
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 113775-47-6 68602 5311068
18
Etomidate Approved Phase 4,Phase 3,Not Applicable 33125-97-2 36339 667484
19
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 437-38-7 3345
20
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59467-70-8 4192
21
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2078-54-8 4943
22
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
23
Dexlansoprazole Approved, Investigational Phase 4,Phase 3,Phase 2 138530-94-6, 103577-45-3 9578005
24
Lansoprazole Approved, Investigational Phase 4,Phase 3,Phase 2 103577-45-3 3883
25
Omalizumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 242138-07-4
26
Terbutaline Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 23031-25-6 5403
27
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-61-7 60961
28
Bambuterol Approved, Investigational Phase 4,Phase 1 81732-65-2, 81732-46-9 54766
29
Azelastine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58581-89-8 2267
30
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 75614-87-8, 51-45-6 774
31
Xylometazoline Approved, Investigational Phase 4,Phase 3,Not Applicable 526-36-3 5709
32
Capsaicin Approved Phase 4,Phase 2,Early Phase 1,Not Applicable 404-86-4 1548943
33
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 51-43-4 5816
34
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 329-65-7 838
35
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 26787-78-0 33613
36
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 69-65-8 453 6251
37
Cetirizine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 83881-51-0 2678
38
Cilostazol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 73963-72-1 2754
39
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 378-44-9 9782
40
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2180-92-9, 38396-39-3 2474
41
Ketorolac Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 74103-06-3, 66635-83-4 3826
42
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 57-27-2 5288826
43
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 84057-95-4 71273 175805
44
Atropine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 5908-99-6, 51-55-8 174174
45
Rocuronium Approved Phase 4,Phase 3,Not Applicable,Early Phase 1 119302-91-9, 143558-00-3 441290
46
Sevoflurane Approved, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 28523-86-6 5206
47
Neostigmine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 59-99-4 4456
48
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
49
Prilocaine Approved Phase 4,Not Applicable 721-50-6 4906
50
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-78-2 2244

Interventional clinical trials:

(show top 50) (show all 6809)
# Name Status NCT ID Phase Drugs
1 Assessing Decision Maker Tools for Asthma: the Asthma APGAR Unknown status NCT01446315 Phase 4
2 Optimization of Inhaled Corticosteroid Treatment in Adult Patients With Asthma Guided by Exhaled NO Measurement at Home Unknown status NCT01783132 Phase 4
3 Efficacy and Safety of Activation Energy Serum (AES) Versus Placebo in Persistent Asthma. Unknown status NCT01939951 Phase 4
4 Effect of Vitamin D Supplementation on the Control of Asthma in Children at a South African Academic Hospital Unknown status NCT02053402 Phase 4 Vitamin D
5 Vitamin D for the Treatment of Severe Asthma Unknown status NCT00712205 Phase 4 Placebo;Calcitriol
6 Low Exhaled NO and ICS in Suspected Asthma Unknown status NCT02771717 Phase 4 Budesonide (Pulmicort);Placebo - dummy inhaler
7 A Pilot Study Involving an Asthma Management Program for Inner-city Early Head Start Children Unknown status NCT00624429 Phase 4 Budesonide respules
8 Inflammatory, Functional and Image Composite Measure to Define Asthma Control Unknown status NCT00597064 Phase 4 prednisone
9 Assessment of Utility of Exhaled Nitric Oxide Measurement for Treatment Monitoring in Children With Asthma Unknown status NCT00500253 Phase 4
10 Fluticasone/Salmeterol (FP/SM) Versus Double the Dose Fluticasone (FP) in Patients With Mild to Moderate Asthma Unknown status NCT00830505 Phase 4 fluticasone/ salmeterol;fluticasone
11 Evaluation of Efficacy of House Dust Mite Immunotherapy in Children With Bronchial Asthma Unknown status NCT00496574 Phase 4
12 Effects of Su-Huang Antitussive Capsule on Cough Variant Asthma Unknown status NCT01584804 Phase 4 Su-Huang antitussive capsule;Sugar pill
13 Nebulized Magnesium Sulfate as an Adjunct to Standard Therapy in Asthma Exacerbation Unknown status NCT02584738 Phase 4 Nebulized Magnesium Sulfate;Nebulized isotonic saline;Nebulized Salbutamol;Ipratropium bromide;Methylprednisolone or Prednisolone
14 Effects of Leukotriene Modulator Montelukast on Cough Variant Asthma Unknown status NCT01404013 Phase 4 ICS/LABA;Montelukast;ICS/LABA and Montelukast
15 Efficacy and Safety Study of Procaterol Hydrochloride to Treat Patients With Cough Variant Asthma (CVA) Unknown status NCT01170429 Phase 4 Procaterol hydrochloride;Meptin placebo
16 Effect of Dexmedetomidine on Levels of Plasma Inflammatory Factor in Asthma Patients Undergoing General Anesthesia Unknown status NCT02289391 Phase 4 Anesthesia induction;Anesthesia maintenance;Assisted anesthesia
17 Treatment Efficacy of Budesonide/Formoterol in Cough Variant Asthma and Typical Asthma Patients Unknown status NCT02934945 Phase 4 budesonide 160μg/formoterol 4.5μg
18 Assessment of Sublingual Immunotherapy in Children Allergic to House Dust Mites Unknown status NCT01052610 Phase 4 sublingual house dust mites allergen extract;placebo in sublingual applicator
19 Effect of Specific Immunotherapy to Dust Mites in Children With Asthma Unknown status NCT00496561 Phase 4
20 Study to Assess the Incidence of Local Oropharyngeal and Laryngeal Adverse Effects of Advair DISKUS 250/50 Mcg BID Unknown status NCT00235053 Phase 4 fluticasone/salmeterol DISKUS 250/50
21 A Randomized, Double-Blind, Placebo-Controlled Study of Gastroesophageal Reflux Disease Therapy. Unknown status NCT00237068 Phase 4 Lansoprazole; Solutab
22 Extra-fine Formoterol/Beclomethasone in Asthmatic Crisis Unknown status NCT02345993 Phase 4 Extra fine Formoterol/Beclomethasone
23 Comparison of Daily Mometasone Furoate Nasal Spray Alone Versus a Combination With Montelukast for Treatment of Chronic Rhinosinusitis With Asthma After Functional Endoscopic Sinus Surgery Unknown status NCT02110654 Phase 4 Montelukast;mometasone furoate nasal spray
24 Onset of Action of Advair Hydrofluoroalkane (HFA) 115/21 in Comparison to Symbicort Pressurised Metered-Dose Inhalers (pMDI) 160/4.5 Measured by Impulse Oscillometry (IOS) Unknown status NCT00867737 Phase 4 Advair HFA MDI 115/21;Symbicort 160/4.5 pMDI
25 Effect of Xolair on Airway Hyperresponsiveness Unknown status NCT00208234 Phase 4 Omalizumab;Placebo for Omalizumab;omalizumab
26 Sublingual Immunotherapy With House Dust Mite Extract in Asthmatic Children Unknown status NCT00172341 Phase 4 Staloral TM
27 Concentrations of Salmeterol in Blood and Urine Unknown status NCT00914901 Phase 4 inhaled salmeterol
28 Terbutaline Concentrations in Blood and Urine Unknown status NCT00914797 Phase 4 inhaled and oral terbutaline
29 Efficacy of Bronchial Thermoplasty in Korean Unknown status NCT02031263 Phase 4
30 Concentrations of Formoterol in Blood and Urine Unknown status NCT00914654 Phase 4 inhaled formoterol
31 Assessment of Airway Responsiveness and Treatment Efficacy in Asthmatics Unknown status NCT02574975 Phase 4 methacholine;adenosine monophosphate;leukotriene D4;budesonide /formoterol
32 Rapid Onset Action of Salbutamol Versus Formoterol Unknown status NCT00900874 Phase 4 salbutamol;Formoterol
33 The Effect of Bronchodilator on Eosinophilic Bronchitis and Cough Variant Asthma Unknown status NCT02002754 Phase 4 Bambuterol Hydrochloride tablets
34 mRNA Expression as a Biomarker of Omalizumab Response Unknown status NCT01584687 Phase 4
35 A Pilot Efficacy Study of Inhaled Albuterol Delivered With Akita Breath Control Unknown status NCT00385359 Phase 4 Albuterol
36 Treatment of Acute Asthma in ER With Combination of Systemic Steroids and Inhaled Steroids Unknown status NCT00397267 Phase 4 inhalation of corticosteroids
37 Efficacy and Safety of LAIS® Mites Sublingual Tablets Unknown status NCT02277483 Phase 4 LAIS®
38 4"S" - Seasonal Symptoms Suppression Study Unknown status NCT02557269 Phase 4 Xylometazoline - intranasal application;Azelastine - intranasal application;Mometasone furoate - intranasal application;Hydroxyl-propyl-methyl cellulose powder - intranasal application;Bilastine 20 mg;Prednisolone 5 mg
39 Comparative Study of Sinol and Sinol-M in Patients With Congestion Due to Allergic Rhinitis Unknown status NCT00825656 Phase 4 Sinol or Sinol-M nasal spray
40 POLlinosis and Exhaled Breath Temperature Unknown status NCT01785394 Phase 4 5 grass allergen extract
41 Inhaler Lung Deposition in Chronic Obstructive Pulmonary Disease (COPD) Unknown status NCT01721291 Phase 4 SALBUTAMOL
42 Immunological Mechanisms of Oralair® in Patients With Seasonal Allergic Rhinitis Unknown status NCT02014623 Phase 4 Control
43 Preterm Infant Inhaled Albuterol Dosing Unknown status NCT02447250 Phase 4 Varied albuterol dose response
44 Bronchiolitis All-study, SE-Norway Unknown status NCT00817466 Phase 4 Racemic adrenaline;Isotonic saline
45 Montelukast for Persistent Cough in Young People and Adults Unknown status NCT01279668 Phase 4 Montelukast;Placebo
46 Evaluate the Effects of Formoterol and Beclomethasone Dipropionate Combination Therapy on Small Airways Function Unknown status NCT01466712 Phase 4 Tiotropium + formoterol/beclometasone;tiotropium + placebo
47 Comparing Fluticasone-Salmeterol in Chronic Obstructive Pulmonary Disease (COPD) and Sleep Unknown status NCT00731770 Phase 4 fluticasone/salmeterol 250/50;placebo
48 Can we Help People With the Oral Allergy Syndrome Eat Fresh Fruit? Unknown status NCT01431859 Phase 4
49 Airway Clearance for Prevention of COPD Exacerbation Unknown status NCT00181207 Phase 4
50 Middle Meatal Bacteriology During Acute Respiratory Infection in Children Unknown status NCT00545961 Phase 4 placebo;amoxicillin clavulanate acid

Search NIH Clinical Center for Asthma

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Asthma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Asthma:
Bone marrow-derived mesenchymal stem cells for severe refractory asthma
Embryonic/Adult Cultured Cells Related to Asthma:
Mouse bone marrow-derived mesenchymal stem cells (family) PMIDs: 21653527 20801416

Cochrane evidence based reviews: asthma

Genetic Tests for Asthma

Genetic tests related to Asthma:

# Genetic test Affiliating Genes
1 Asthma, Susceptibility to 29 ADRB2 ALOX5 CCL11 HLA-G HNMT IL13 MUC7 PHF11 PLA2G7 SCGB3A2 TNF
2 Asthma 29

Anatomical Context for Asthma

MalaCards organs/tissues related to Asthma:

41
Lung, Testes, Heart, T Cells, Neutrophil, Skin, Endothelial
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Asthma:
# Tissue Anatomical CompartmentCell Relevance
1 Lung Trachea Airway Smooth Muscle Cells Potential therapeutic candidate, affected by disease

Publications for Asthma

Articles related to Asthma:

(show top 50) (show all 7283)
# Title Authors Year
1
Eicosapentaenoic Acid Enhances the Effects of Mesenchymal Stromal Cell Therapy in Experimental Allergic Asthma. ( 29881388 )
2018
2
The effects of bone marrow-derived mesenchymal stem cells on ovalbumin-induced allergic asthma and cytokine responses in mice. ( 29922428 )
2018
3
Economic Burden of Pediatric Asthma: Annual Cost of Disease in Iran. ( 29445636 )
2018
4
Lactic Acidosis and Asthma Exacerbation. ( 29801682 )
2018
5
Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma. ( 29325868 )
2018
6
Altered expression of IL-18 binding protein and IL-18 receptor in basophils and mast cells of asthma patients. ( 29505668 )
2018
7
Hair analysis to monitor adherence to prescribed chronic inhaler drug therapy in patients with asthma or COPD. ( 29981458 )
2018
8
Association Between Obesity and Acute Severity Among Patients Hospitalized for Asthma Exacerbation. ( 29452277 )
2018
9
Eosinophil-derived exosomes contribute to asthma remodelling by activating structural lung cells. ( 29451337 )
2018
10
Advances and Evolving Concepts in Allergic Asthma. ( 29427987 )
2018
11
Expansion of a CD26<sup>low</sup>effector TH subset and reduction of circulating levels of sCD26 in stable allergic asthma in adults. ( 29297467 )
2018
12
Relationship Between Rhinitis, Asthma, and Eczema and the Presence of Sensitization in Young Swiss Adults. ( 29977657 )
2018
13
Changes in smoking prevalence and cessation support, and factors associated with successful smoking cessation in Swedish patients with asthma and COPD. ( 29321831 )
2018
14
Dexamethasone alleviates allergic asthma immature rat through Toll like receptor 4. ( 29364486 )
2018
15
Beware of beta! A case of salbutamol-induced lactic acidosis in severe asthma. ( 29914901 )
2018
16
Basophil Membrane Expression of Epithelial Cytokine Receptors in Patients with Severe Asthma. ( 29402810 )
2018
17
Modeling asthma: Pitfalls, promises, and the road ahead. ( 29451705 )
2018
18
The Effects of Caregiver Depression on Childhood Asthma: Pathways and Mechanisms. ( 29981440 )
2018
19
A Randomized, Multicenter, Double-blind, Phase III Study to Evaluate the Efficacy on Allergic Rhinitis and Safety of a Combination Therapy of Montelukast and Levocetirizine in Patients With Asthma and Allergic Rhinitis. ( 29945738 )
2018
20
Nonallergic Asthma and Its Severity: Biomarkers for Its Discrimination in Peripheral Samples. ( 29977241 )
2018
21
Airway Autoimmune Inflammatory Response (AAIR) Syndrome: An Asthma-Autoimmune Overlap Disorder? ( 29449341 )
2018
22
Polymorphisms in inflammasome genes and risk of asthma in Brazilian children. ( 29154202 )
2018
23
Association Between Inhaled Corticosteroid Use and Bone Fracture in Children With Asthma. ( 29131874 )
2018
24
Modeling Unobserved Heterogeneity in Susceptibility to Ambient Benzo[a]pyrene Concentration among Children with Allergic Asthma Using an Unsupervised Learning Algorithm. ( 29320438 )
2018
25
Does adiposity mediate the relationship between socioeconomic position and non-allergic asthma in childhood? ( 29367283 )
2018
26
Is IgE or eosinophils the key player in allergic asthma pathogenesis? Are we asking the right question? ( 29879991 )
2018
27
A Randomized Trial of Itraconazole vs Prednisolone in Acute-Stage Allergic Bronchopulmonary Aspergillosis Complicating Asthma. ( 29331473 )
2018
28
IgE-expressing memory B cells and plasmablasts are increased in blood of children with asthma, food allergy and atopic dermatitis. ( 29380876 )
2018
29
Pulmonary interstitial emphysema in fatal asthma: case report and histopathological review. ( 29554886 )
2018
30
Subcutaneous immunotherapy suppresses Th2 inflammation and induces neutralizing antibodies, but sublingual immunotherapy suppresses airway hyperresponsiveness in grass pollen mouse models for allergic asthma. ( 29752757 )
2018
31
IL-17A gene polymorphism rs2275913 is associated with the development of asthma after bronchiolitis in infancy. ( 28647382 )
2018
32
Everyone with asthma should have a metered dose inhaler and a spacer. ( 29449208 )
2018
33
Subcutaneous allergen immunotherapy may be a suitable treatment for exacerbator allergic asthma. ( 29803710 )
2018
34
Variation in the TEK gene is not associated with asthma but with allergic conjunctivitis. ( 29667338 )
2018
35
Developmental endothelial locus-1 (Del-1) antagonizes Interleukin-17-mediated allergic asthma. ( 29437247 )
2018
36
Cold weather increases respiratory symptoms and functional disability especially among patients with asthma and allergic rhinitis. ( 29973669 )
2018
37
MUC1 deficiency mediates corticosteroid insensitivity in asthma. ( 29978485 )
2018
38
Comparison of Specific Immunoglobulin E with the Skin Prick Test in the Diagnosis of House Dust Mites and Cockroach Sensitization in Patients with Asthma and/or Allergic Rhinitis. ( 29950531 )
2018
39
March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation. ( 29854835 )
2018
40
Exposure to diisodecyl phthalate exacerbated Th2 and Th17-mediated asthma through aggravating oxidative stress and the activation of p38 MAPK. ( 29448086 )
2018
41
Is eosinophilic esophagitis an equivalent of pollen allergic asthma? Analysis of biopsies and therapy guided by component resolved diagnosis. ( 29338961 )
2018
42
Achalasia with massive oesophageal dilation causing tracheomalacia and asthma symptoms. ( 29321968 )
2018
43
Correlation between upper and lower airway inflammations in patients with combined allergic rhinitis and asthma syndrome: A comparison of patients initially presenting with allergic rhinitis and those initially presenting with asthma. ( 29434763 )
2018
44
Intranasal administration of probiotic Lactobacillus rhamnosus GG prevents birch pollen-induced allergic asthma in a murine model. ( 29888398 )
2018
45
Comparison of findings on thoracic computed tomography with the severity and duration of bronchial asthma in patients with eosinophilic granulomatosis with polyangiitis. ( 29857992 )
2018
46
A Randomized, Double-Blind, Placebo-Controlled Trial of Escitalopram in Patients with Asthma and Major Depressive Disorder. ( 29409976 )
2018
47
Allergic asthma is associated with increased risk of infections requiring antibiotics. ( 29413341 )
2018
48
Role of neutrophils in allergic asthma. ( 29883877 )
2018
49
Thunderstorm asthma: controlling (deadly) grass pollen allergy. ( 29437642 )
2018
50
Health Services Utilization in Asthma Exacerbations and PM<sub>10</sub> Levels in Rural Colorado. ( 29979621 )
2018