ASRT1
MCID: AST055
MIFTS: 26

Asthma-Related Traits 1 (ASRT1)

Categories: Genetic diseases, Immune diseases, Skin diseases

Aliases & Classifications for Asthma-Related Traits 1

MalaCards integrated aliases for Asthma-Related Traits 1:

Name: Asthma-Related Traits 1 57 75
Asthma-Related Traits, Susceptibility to, 1 57 29 6 73
Asthma, Susceptibility to, 1 57 13
Asrt1 57 75
Asthma-Related Traits, Susceptibility to, Type 1 40
Asthma 1 57
As1 57

Classifications:



External Ids:

OMIM 57 607277
MedGen 42 C1846534
MeSH 44 D001249
UMLS 73 C1846534

Summaries for Asthma-Related Traits 1

OMIM : 57 Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, and dyspnea; bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test; serum IgE levels; atopy; and atopic dermatitis (Laitinen et al., 2001; Illig and Wjst, 2002; Pillai et al., 2006). For a general phenotypic description and a discussion of genetic heterogeneity of asthma, see 600807. (607277)

MalaCards based summary : Asthma-Related Traits 1, also known as asthma-related traits, susceptibility to, 1, is related to colorectal cancer and osteogenic sarcoma. An important gene associated with Asthma-Related Traits 1 is PTGDR (Prostaglandin D2 Receptor). Affiliated tissues include testes, skin and lung.

UniProtKB/Swiss-Prot : 75 Asthma-related traits 1: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.

Related Diseases for Asthma-Related Traits 1

Diseases in the Asthma-Related Traits 1 family:

Asthma-Related Traits 2 Asthma-Related Traits 3
Asthma-Related Traits 4 Asthma-Related Traits 5
Asthma-Related Traits 6 Asthma-Related Traits 7
Asthma-Related Traits 8

Diseases related to Asthma-Related Traits 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 colorectal cancer 10.1
2 osteogenic sarcoma 10.1
3 asthma 10.1
4 bladder cancer 10.0
5 hepatocellular carcinoma 10.0
6 esophageal cancer 10.0
7 ovarian cancer 10.0
8 small cell cancer of the lung 10.0
9 lung cancer 10.0
10 cervical cancer 10.0
11 inflammatory bowel disease 10.0
12 squamous cell carcinoma 10.0
13 respiratory failure 9.7

Graphical network of the top 20 diseases related to Asthma-Related Traits 1:



Diseases related to Asthma-Related Traits 1

Symptoms & Phenotypes for Asthma-Related Traits 1

Clinical features from OMIM:

607277

Drugs & Therapeutics for Asthma-Related Traits 1

Search Clinical Trials , NIH Clinical Center for Asthma-Related Traits 1

Genetic Tests for Asthma-Related Traits 1

Genetic tests related to Asthma-Related Traits 1:

# Genetic test Affiliating Genes
1 Asthma-Related Traits, Susceptibility to, 1 29 PTGDR

Anatomical Context for Asthma-Related Traits 1

MalaCards organs/tissues related to Asthma-Related Traits 1:

41
Testes, Skin, Lung

Publications for Asthma-Related Traits 1

Articles related to Asthma-Related Traits 1:

# Title Authors Year
1
Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial. ( 30416083 )
2018
2
Asthma 1-2-3: a low literacy multimedia tool to educate African American adults about asthma. ( 19353250 )
2009
3
A 47-year-old woman with severe asthma, 1 year later. ( 11466125 )
2001
4
Adherence and compliance in the management of asthma: 1. ( 10076205 )
1998
5
Steroid-sparing drugs in steroid-dependent asthma: 1-cyclosporin-A. ( 9510676 )
1997
6
Practical aspects of aerosol therapy in asthma (1) ( 9141764 )
1996
7
Duration of the development stages of house dust mites Dermatophagoides farinae and D. pteronyssinus under controlled temperatures and relative humidities to pave the way in front of the workers in the field of house-dust mite bronchial asthma. 1. Pre-imaginal period. ( 6663096 )
1983
8
Management of asthma. 1. Approach. ( 854495 )
1977
9
Acute respiratory failure due to asthma. 1. Pathophysiology. ( 5566205 )
1971

Variations for Asthma-Related Traits 1

ClinVar genetic disease variations for Asthma-Related Traits 1:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 PTGDR PTGDR, HAPLOTYPE TCT undetermined variant risk factor
2 PTGDR PTGDR, HAPLOTYPE CCC undetermined variant risk factor

Expression for Asthma-Related Traits 1

Search GEO for disease gene expression data for Asthma-Related Traits 1.

Pathways for Asthma-Related Traits 1

GO Terms for Asthma-Related Traits 1

Sources for Asthma-Related Traits 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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