ASRT1
MCID: AST055
MIFTS: 32

Asthma-Related Traits 1 (ASRT1)

Categories: Genetic diseases, Immune diseases, Skin diseases

Aliases & Classifications for Asthma-Related Traits 1

MalaCards integrated aliases for Asthma-Related Traits 1:

Name: Asthma-Related Traits 1 57 72
Asthma-Related Traits, Susceptibility to, 1 57 29 6 70
Asthma, Susceptibility to, 1 57 13
Asrt1 57 72
Asthma-Related Traits, Susceptibility to, Type 1 39
Asthma 1 57
As1 57

Classifications:



External Ids:

OMIM® 57 607277
MeSH 44 D001249
MedGen 41 C1846534
UMLS 70 C1846534

Summaries for Asthma-Related Traits 1

OMIM® : 57 Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, and dyspnea; bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test; serum IgE levels; atopy; and atopic dermatitis (Laitinen et al., 2001; Illig and Wjst, 2002; Pillai et al., 2006). For a general phenotypic description and a discussion of genetic heterogeneity of asthma, see 600807. (607277) (Updated 20-May-2021)

MalaCards based summary : Asthma-Related Traits 1, also known as asthma-related traits, susceptibility to, 1, is related to familial isolated dilated cardiomyopathy and cardiomyopathy, dilated, 1g. An important gene associated with Asthma-Related Traits 1 is PTGDR (Prostaglandin D2 Receptor). The drugs Propofol and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and brain.

UniProtKB/Swiss-Prot : 72 Asthma-related traits 1: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.

Related Diseases for Asthma-Related Traits 1

Diseases in the Asthma-Related Traits 1 family:

Asthma-Related Traits 2 Asthma-Related Traits 3
Asthma-Related Traits 4 Asthma-Related Traits 5
Asthma-Related Traits 6 Asthma-Related Traits 7
Asthma-Related Traits 8

Diseases related to Asthma-Related Traits 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 952)
# Related Disease Score Top Affiliating Genes
1 familial isolated dilated cardiomyopathy 12.0
2 cardiomyopathy, dilated, 1g 11.9
3 muscular dystrophy, limb-girdle, autosomal recessive 10 11.9
4 lung cancer 11.6
5 hepatocellular carcinoma 11.6
6 colorectal cancer 11.6
7 gastric cancer 11.5
8 breast cancer 11.4
9 bladder cancer 11.4
10 atrial standstill 1 11.3
11 lung cancer susceptibility 3 11.3
12 glioma susceptibility 1 11.3
13 squamous cell carcinoma 11.3
14 ovarian cancer 11.3
15 cervical cancer 11.3
16 retinitis pigmentosa 11.3
17 osteogenic sarcoma 11.3
18 glioma 11.2
19 glioblastoma 11.2
20 prostate cancer 11.2
21 hypercholesterolemia, familial, 1 11.2
22 esophageal cancer 11.2
23 nasopharyngeal carcinoma 11.2
24 renal cell carcinoma, nonpapillary 11.2
25 homozygous familial hypercholesterolemia 11.2
26 pancreatic cancer 11.2
27 high grade glioma 11.2
28 neuropathy, hereditary sensory and autonomic, type iia 11.1
29 fundus dystrophy 11.1
30 vas deferens, congenital bilateral aplasia of 11.1
31 myopathy 11.1
32 diffuse large b-cell lymphoma 11.1
33 endometrial cancer 11.1
34 dilated cardiomyopathy 11.1
35 cone-rod dystrophy 2 11.1
36 rare genetic deafness 11.1
37 schizophrenia 11.1
38 myeloma, multiple 11.1
39 chromophobe renal cell carcinoma 11.1
40 retinitis pigmentosa 11 11.0
41 cardiomyopathy, dilated, 1b 11.0
42 usher syndrome 11.0
43 gallbladder cancer 11.0
44 aortic aneurysm 11.0
45 neuroblastoma 11.0
46 pancreatic ductal adenocarcinoma 11.0
47 oral squamous cell carcinoma 11.0
48 melanoma 11.0
49 myopathy, myofibrillar, 5 11.0
50 familial isolated restrictive cardiomyopathy 11.0

Graphical network of the top 20 diseases related to Asthma-Related Traits 1:



Diseases related to Asthma-Related Traits 1

Symptoms & Phenotypes for Asthma-Related Traits 1

Clinical features from OMIM®:

607277 (Updated 20-May-2021)

Drugs & Therapeutics for Asthma-Related Traits 1

Drugs for Asthma-Related Traits 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
2 Anesthetics
3 Hypnotics and Sedatives
4 Anesthetics, General
5 Anesthetics, Intravenous

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Influence of Propofol on Alveolar Macrophage Immunity in Asthmatic Patients Undergoing General Anesthesia Completed NCT00676416 2,6-Diisopropylphenol
2 Development and Validation of a Sputum Biomarker mRNA Panel for the Diagnostic Work-up of Asthma 1. Completed NCT01224938

Search NIH Clinical Center for Asthma-Related Traits 1

Genetic Tests for Asthma-Related Traits 1

Genetic tests related to Asthma-Related Traits 1:

# Genetic test Affiliating Genes
1 Asthma-Related Traits, Susceptibility to, 1 29 PTGDR

Anatomical Context for Asthma-Related Traits 1

MalaCards organs/tissues related to Asthma-Related Traits 1:

40
Heart, Bone, Brain, Lung, Skin, Kidney, Thyroid

Publications for Asthma-Related Traits 1

Articles related to Asthma-Related Traits 1:

(show top 50) (show all 185)
# Title Authors PMID Year
1
Role of prostanoid DP receptor variants in susceptibility to asthma. 57 6
15496624 2004
2
A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families: evidence for a major susceptibility locus on chromosome 2p. 57
16391567 2006
3
A major susceptibility gene for asthma maps to chromosome 14q24. 57
12119603 2002
4
Genetics of asthma and related phenotypes. 57
12065182 2002
5
A susceptibility locus for asthma-related traits on chromosome 7 revealed by genome-wide scan in a founder population. 57
11326283 2001
6
Prostaglandin D2 as a mediator of allergic asthma. 57
10720327 2000
7
Suggestive evidence for genetic linkage between IgE phenotypes and chromosome 14q markers. 57
10351921 1999
8
Efficacy of unsupervised exercise in adults with obstructive lung disease: a systematic review and meta-analysis. 61
33685962 2021
9
Inhaled corticosteroids and risk of lung cancer: A systematic review and meta-analysis. 61
33053199 2021
10
A mixed-methods analysis of younger adults' perceptions of asthma, self-management, and preventive care: "This isn't helping me none". 61
33007115 2021
11
Focus on asthma 1: the state of care for children and young people in the UK and globally. 61
32985169 2021
12
Evaluating the real-life effect of MP-AzeFlu on asthma outcomes in patients with allergic rhinitis and asthma in UK primary care. 61
33376573 2020
13
Managing Asthma in Adolescents and Adults: 2020 Asthma Guideline Update From the National Asthma Education and Prevention Program. 61
33270095 2020
14
Environmental risk factors, protective factors, and peripheral biomarkers for ADHD: an umbrella review. 61
33069318 2020
15
Global Quality Standard for Identification and Management of Severe Asthma. 61
32725419 2020
16
A rare case of refractory asthma managed with azathioprine. 61
31164022 2020
17
Fractional Exhaled Nitric Oxide as an Inflammatory Biomarker in Chronic Obstructive Pulmonary Disease (COPD) with or without Concurrent Diagnosis of Asthma: The Canadian Cohort Obstructive Lung Disease (CanCOLD). 61
32584165 2020
18
The course of asthma: A population-based 10-year study examining asthma remission in children diagnosed with asthma in preschool. 61
32478962 2020
19
Profiles of Nicotine and Cannabis Exposure among Young Adults with Asthma. 61
32703091 2020
20
Applied Computing to Education on Noncommunicable Chronic Diseases: A Systematic Mapping Study. 61
30807261 2020
21
Perceptions of Asthma and Exercise, and Associations With Weight Status and Asthma Morbidity in Urban Children. 61
31301420 2020
22
Mepolizumab in Severe Eosinophilic Asthma: A 2-Year Follow-Up in Specialized Asthma Clinics in Greece: An Interim Analysis. 61
32570256 2020
23
Add-on Tiotropium in Chinese Patients With Moderate Asthma: A Pooled Subgroup Analysis of MezzoTinA-Asthma 1 and 2. 61
31172720 2019
24
Hypertensive Postpartum Admissions Among Women Without a History of Hypertension or Preeclampsia. 61
30870276 2019
25
Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial. 61
30416083 2019
26
Efficacy and safety of once-daily fluticasone furoate/vilanterol (FF/VI) versus twice-daily inhaled corticosteroids/long-acting β2-agonists (ICS/LABA) in patients with uncontrolled asthma: An open-label, randomized, controlled trial. 61
30053956 2018
27
Longitudinal urinary metabolomic profiling reveals metabolites for asthma development in early childhood. 61
29679407 2018
28
Food Allergy Is an Important Risk Factor for Childhood Asthma, Irrespective of Whether It Resolves. 61
29153880 2018
29
A retrospective cohort study in severe asthma describing commonly measured biomarkers: Eosinophil count and IgE levels. 61
29413497 2018
30
Long-term efficacy and safety of rilpivirine plus abacavir and lamivudine in HIV-1 infected patients with undetectable viral load. 61
29451870 2018
31
Patients with soft tissue sarcoma comprise a higher probability of comorbidities than cancer-free individuals. A secondary data analysis. 61
27957779 2017
32
Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. 61
28822787 2017
33
Long-term future risk of severe exacerbations: Distinct 5-year trajectories of problematic asthma. 61
28295424 2017
34
Clinical Characteristics of Patients with Chronic Rhinosinusitis with Nasal Polyps, Asthma, and Aspirin-Exacerbated Respiratory Disease. 61
28286156 2017
35
Occupational asthma caused by acrylic compounds from SHIELD surveillance (1989-2014). 61
28431005 2017
36
PhD Forum: Multimodal IoT and EMR based Smart Health Application for Asthma Management in Children. 61
29431176 2017
37
Reslizumab in patients with inadequately controlled late-onset asthma and elevated blood eosinophils. 61
28159511 2017
38
Asthma Among Employed Adults, by Industry and Occupation - 21 States, 2013. 61
27906909 2016
39
Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy. 61
27788565 2016
40
DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis. 61
27038909 2016
41
A REALLY WHEEZY WAY TO SAVE MONEY. 61
27540214 2016
42
Characterization of asthma endotypes: implications for therapy. 61
27499539 2016
43
Vitamin D3 for uncontrolled childhood asthma: A pilot study. 61
26845753 2016
44
Prevalence of Exercise-Induced Bronchoconstriction Measured by Standardized Testing in Healthy College Athletes. 61
26860398 2016
45
Prevalence of childhood asthma in Ulaanbaatar, Mongolia in 2009. 61
26666488 2016
46
Identification of children at risk of influenza-related complications in primary and ambulatory care: a systematic review and meta-analysis. 61
25481379 2015
47
Respiratory Health in Cleaners in Northern Europe: Is Susceptibility Established in Early Life? 61
26168149 2015
48
Addition of antileukotriene agents to inhaled corticosteroids in children with persistent asthma. 61
25414582 2014
49
Trends in eczema, rhinitis, and rye grass sensitization in a longitudinal asthma cohort. 61
24767696 2014
50
[The prevalence and risk factors of occupational asthma in workers exposed to isocyanate]. 61
24199879 2013

Variations for Asthma-Related Traits 1

ClinVar genetic disease variations for Asthma-Related Traits 1:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 PTGDR PTGDR, HAPLOTYPE TCT Variation risk factor 5405 GRCh37:
GRCh38:
2 PTGDR PTGDR, HAPLOTYPE CCC Variation risk factor 5406 GRCh37:
GRCh38:

Expression for Asthma-Related Traits 1

Search GEO for disease gene expression data for Asthma-Related Traits 1.

Pathways for Asthma-Related Traits 1

GO Terms for Asthma-Related Traits 1

Sources for Asthma-Related Traits 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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