MCID: AST055
MIFTS: 30

Asthma-Related Traits 1

Categories: Genetic diseases, Immune diseases

Aliases & Classifications for Asthma-Related Traits 1

MalaCards integrated aliases for Asthma-Related Traits 1:

Name: Asthma-Related Traits 1 57 75
Asthma-Related Traits, Susceptibility to, 1 57 29 6 73
Asthma, Susceptibility to, 1 57 13
Asrt1 57 75
Asthma-Related Traits, Susceptibility to, Type 1 40
Asthma 1 57
As1 57

Classifications:



External Ids:

OMIM 57 607277
MedGen 42 C1846534
MeSH 44 D001249
UMLS 73 C1846534

Summaries for Asthma-Related Traits 1

OMIM : 57 Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, and dyspnea; bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test; serum IgE levels; atopy; and atopic dermatitis (Laitinen et al., 2001; Illig and Wjst, 2002; Pillai et al., 2006). For a general phenotypic description and a discussion of genetic heterogeneity of asthma, see 600807. (607277)

MalaCards based summary : Asthma-Related Traits 1, also known as asthma-related traits, susceptibility to, 1, is related to asthma and respiratory failure. An important gene associated with Asthma-Related Traits 1 is PTGDR (Prostaglandin D2 Receptor). The drugs Bupivacaine and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and testes.

UniProtKB/Swiss-Prot : 75 Asthma-related traits 1: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.

Related Diseases for Asthma-Related Traits 1

Diseases in the Asthma-Related Traits 1 family:

Asthma-Related Traits 2 Asthma-Related Traits 3
Asthma-Related Traits 4 Asthma-Related Traits 5
Asthma-Related Traits 6 Asthma-Related Traits 7
Asthma-Related Traits 8

Diseases related to Asthma-Related Traits 1 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 asthma 10.0
2 respiratory failure 9.6

Symptoms & Phenotypes for Asthma-Related Traits 1

Clinical features from OMIM:

607277

Drugs & Therapeutics for Asthma-Related Traits 1

Drugs for Asthma-Related Traits 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 858)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4,Phase 2,Not Applicable 2180-92-9, 38396-39-3 2474
2
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
3
Carbamazepine Approved, Investigational Phase 4,Phase 3 298-46-4 2554
4
Coal tar Approved Phase 4,Phase 1 8007-45-2
5
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-61-6, 62-31-7 681
6
Olanzapine Approved, Investigational Phase 4,Phase 3 132539-06-1 4585
7
Oxcarbazepine Approved Phase 4,Phase 3 28721-07-5 34312
8
Valproic Acid Approved, Investigational Phase 4,Phase 3 99-66-1 3121
9
Ziprasidone Approved Phase 4 146939-27-7 60854
10
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
11
Esomeprazole Approved, Investigational Phase 4,Phase 1 161796-78-7, 119141-88-7 4594 9579578
12
Gefitinib Approved, Investigational Phase 4,Phase 3,Phase 2 184475-35-2 123631
13
Menthol Approved Phase 4,Not Applicable 2216-51-5 16666
14
Ropivacaine Approved Phase 4,Phase 1,Phase 2,Not Applicable 84057-95-4 71273 175805
15
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
16
Morphine Approved, Investigational Phase 4,Phase 1,Phase 2 57-27-2 5288826
17
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 64-17-5 702
18
Rocuronium Approved Phase 4,Not Applicable 119302-91-9, 143558-00-3 441290
19
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 26787-78-0 33613
20
Clarithromycin Approved Phase 4,Phase 3,Phase 2,Not Applicable 81103-11-9 84029
21
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
22
Metronidazole Approved Phase 4,Phase 3,Phase 2 443-48-1 4173
23
Ofloxacin Approved Phase 4 82419-36-1 4583
24
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
25
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
26
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1 21679-14-1, 75607-67-9 30751
27
rituximab Approved Phase 4,Phase 3,Phase 2 174722-31-7 10201696
28
Vidarabine Approved, Investigational Phase 4,Phase 2,Phase 1 24356-66-9 32326 21704
29
Bimatoprost Approved, Investigational Phase 4,Phase 2 155206-00-1 5311027
30
Timolol Approved Phase 4 26839-75-8 33624 5478
31
Travoprost Approved Phase 4 157283-68-6 5282226
32
Fluticasone Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2 90566-53-3 62924
33
Cilastatin Approved, Investigational Phase 4 82009-34-5 5280454 6435415
34
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
35
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
36
Tigecycline Approved Phase 4 220620-09-7 5282044
37
Desoximetasone Approved Phase 4 382-67-2 5311067
38
Dimenhydrinate Approved Phase 4 523-87-5 441281
39
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 75614-87-8, 51-45-6 774
40 Olodaterol Approved Phase 4 868049-49-4
41
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
42
Glatiramer Acetate Approved, Investigational Phase 4,Phase 3 147245-92-9 3081884
43
Interferon beta-1a Approved, Investigational Phase 4,Phase 2,Phase 3 145258-61-3 6438354
44
Treprostinil Approved, Investigational Phase 4 81846-19-7 54786 6918140
45
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
46
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2 50-23-7 5754
47
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
48
Brinzolamide Approved Phase 4 138890-62-7 68844
49
Latanoprost Approved, Investigational Phase 4,Phase 2 130209-82-4 5282380 5311221
50
Interferon beta-1b Approved Phase 4 145155-23-3

Interventional clinical trials:

(show top 50) (show all 938)
# Name Status NCT ID Phase Drugs
1 Dose Finding Study for Continuous Spinal Anaesthesia Unknown status NCT01680120 Phase 4
2 Evaluation of Dexmedetomidine on Post-operative Narcotic Requirements and Pain Scores in Bariatric Patients Unknown status NCT02604940 Phase 4 Dexmedetomidine;Normal Saline
3 Comparative Efficacy and Acceptability of Antimanic Drugs in Acute Mania Unknown status NCT01893229 Phase 4 Lithium;Valproate;Oxcarbazepine;Quetiapine;Olanzapine;Ziprasidone
4 Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty Unknown status NCT01934049 Phase 4 Total Intravenous Anesthesia and Peripheral nerve blocks
5 Long-term Oral Esomeprazole for Prevention of Peptic Ulcer Rebleeding in High-risk Patients Unknown status NCT02456012 Phase 4 oral esomeprazole 20 mg twice daily;oral esomeprazole 20 mg once daily
6 Multi-Center Study To Examine The Use Of Flex HD® And Strattice In The Repair Of Large Abdominal Wall Hernias Unknown status NCT01987700 Phase 4
7 Efficacy of High Dose Dual Therapy, Sequential Therapy and Triple Therapy in H. Pylori Eradication Completed NCT01163435 Phase 4 high dose dual therapy;sequential therapy;clarithromycin-based triple therapy;levofloxacin-based triple therapy
8 Efficacy, Safety, Tolerability of Gefitinib as 1st Line in Caucasian Patients With EGFR Mutation Positive Advanced NSCLC Completed NCT01203917 Phase 4 Gefitinib
9 Efficacy Response Duration and Toxicity of Rituximab, Fludarabine, and Cyclophosphamide (RFC) as 1st Line Treatment and Rituximab (R) in Maintenance Treatment in Follicular Non Hodgkin (FNH) Lymphoma Completed NCT01124526 Phase 4 Rituximab Fludarabine Cyclophosphamide
10 Safety and Efficacy of LUMIGAN® RC Versus DuoTrav® in Patients Who Require Further Intraocular Pressure (IOP) Reduction Completed NCT01547598 Phase 4 travoprost ophthalmic solution 0.004%;travoprost 0.004% / timolol 0.5% combination ophthalmic solution;Bimatoprost ophthalmic solution 0.01%
11 A Safety and Efficacy Study of Doripenem in Participants With Nosocomial Pneumonia, Complicated Intra-Abdominal Infections and Urinary Tract Infections Completed NCT00965848 Phase 4 Doripenem
12 Use of Mobile Devices and the Internet to Streamline an Asthma Clinical Trial Completed NCT02061280 Phase 4 fluticasone/salmeterol 250/50 Dry Powder Inhaler;fluticasone/salmeterol 100/50 Dry Powder Inhaler;fluticasone 100mcg Dry Powder Inhaler
13 A Study To Determine The Efficacy And Safety Of Tigecycline Compared With Imipenem/Cliastatin to Treat Complicated Intra-Abdominal Infection Completed NCT01721408 Phase 4 Tigecycline;Imipenem/cilastatin
14 Topical Psoriasis Study for Patients Receiving Biologic Therapy Completed NCT02983981 Phase 4 Topicort Topical Spray
15 A Trial Comparing the Effect of Oral Dimenhydrinate Versus Placebo in Children With Gastroenteritis Completed NCT00124787 Phase 4 Dimenhydrinate;Placebo
16 Ropivacaine Use Intraincisionally Versus Intraperitoneally for Post-Laparoscopic Cholecystectomy Pain Completed NCT03265223 Phase 4 0.2% ropivacaine
17 Abdominal Belt Use to Treat Low Back Pain Completed NCT02062918 Phase 4
18 An Efficacy Study of Umeclidinium/Vilanterol With Tiotropium/Olodaterol in COPD Patients Completed NCT02799784 Phase 4 UMEC/VI;TIO/OLO;Albuterol/salbutamol
19 Titration of Intravenous Hydromorphone Completed NCT01892709 Phase 4 Hydromorphone
20 Evaluation of Patient Reported Outcomes in RRMS Patients Candidates for MS Therapy Change and Transitioned to Fingolimod 0.5 mg (EPOC) Completed NCT01534182 Phase 4 Fingolimod;Interferon beta - 1a (IFN);Glatiramer acetate (GA)
21 TRUST-2: Safety and Efficacy of Intravenous Remodulin® in Patients in India With Pulmonary Arterial Hypertension (PAH) Completed NCT03055221 Phase 4 Intravenous Treprostinil
22 Tropical Influenza Control Strategies for the Elderly Completed NCT02655874 Phase 4
23 Effect of Preoperative Estrogen Treatment on Connective Tissues of the Pelvic Floor Completed NCT01778985 Phase 4 Premarin
24 Repository Corticotropin Injection To Treat Rheumatoid Arthritis Patients Who Have Failed Three Biologic Therapies. Completed NCT01966718 Phase 4 Repository corticotropin injection
25 Safety and Efficacy of Adding AZARGA® Adjunctive to Prostaglandin Therapy Completed NCT01263444 Phase 4 Brinzolamide 1% / timolol 0.5% Fixed Combination;Habitual prostaglandin monotherapy
26 Effectiveness, Safety and Immunogenicity of GSK Biologicals' HPV Vaccine GSK580299 (Cervarix TM) Administered in Healthy Adolescents Completed NCT00534638 Phase 4
27 Study Assessing Patient Satisfaction With LATISSE® for Increasing Eyelash Prominence Completed NCT01448525 Phase 4 bimatoprost ophthalmic solution 0.03%;bimatoprost vehicle solution
28 A 6-month, Randomized, Open-label, Patient OutComes, Safety and Tolerability Study of Fingolimod (FTY720) 0.5 mg/Day vs. Comparator in Patients With Relapsing Forms of Multiple Sclerosis Completed NCT01216072 Phase 4 Fingolimod;Standard MS DMTs
29 Memantine and Cognitive Dysfunction in Bipolar Disorder Completed NCT00586066 Phase 4 Memantine;Placebo
30 Use of Pulsed Electromagnetic Fields (PEMF) After Breast Reconstruction Surgery Completed NCT01262599 Phase 4
31 A 6 Month Safety Study Of Ciclesonide Nasal Aerosol (Zetonna®) And Ciclesonide Nasal Spray (Omnaris®) In Subjects 12 Years And Older With Perennial Allergic Rhinitis (PAR) Completed NCT01654536 Phase 4 ciclesonide nasal aerosol;ciclesonide nasal spray
32 Efficacy of Artesunate-amodiaquine and Artemether-lumefantrine for Uncomplicated Malaria in South Kivu, DR Congo Completed NCT02741024 Phase 4 Amodiaquine-Artesunate (ASAQ);Artemether-Lumefantrine (AL)
33 Safety and Efficacy of OsmoPrep® Tablets Versus HalfLytely® and Bisacodyl Tablet Bowel Prep Kit for Colon Cleansing Completed NCT01427296 Phase 4 Polyethylene glycol;Oral sodium phosphate solution
34 Assessment Of Dutasteride (AVODART) In Extending The Time To Progression Of Low-Risk, Localized Prostate Cancer In Men Completed NCT00363311 Phase 4 Dutasteride;Matching placebo
35 "Red Morphine Drops" for Symptomatic Treatment of Dyspnoea in Lung Cancer Completed NCT00338481 Phase 4 Morphine p.o.;Morphine s.c.
36 Study Evaluating Etanercept and Sulphasalazine in Ankylosing Spondylitis Completed NCT00247962 Phase 4 etanercept;sulphasalazine (SSZ)
37 The Effect of Probiotics on Constipation, and Intestinal Microflora in Children With Functional Constipation Completed NCT03054805 Phase 4 Magnesium Oxide;MIYAIRI-BM
38 Postoperative Pain in Single-visit and Multiple-visit Retreatment Cases Completed NCT03042377 Phase 4 Multiple-Visit-"Calcium Hydroxide";Multiple-Visit-"Corticosteroid Paste";Multiple-Visit-"Antibiotic Paste"
39 Escitalopram in Depressive Patients With Acute Coronary Artery Syndrome Completed NCT00419471 Phase 4 Escitalopram;Placebo
40 Efficacy of Dexmedetomidine in Preventing Contrast Induced Nephropathy Completed NCT02137863 Phase 4 Dexmedetomidine;0.9 % NaCl;0.9 % NaCl
41 12-Week Study of Pristiq (Desvenlafaxine) Social Anxiety Disorder Completed NCT01316302 Phase 4 Pristiq;Placebo
42 Anti-histamines and Methacholine Challenges. Completed NCT01985789 Phase 4 Diphenhydramine;cetirizine;desloratadine;placebo
43 Orphenadrine and Methocarbamol for LBP Completed NCT02665286 Phase 4 Orphenadrine;Methocarbamol;Naproxen;Placebo
44 Study of Therapeutic Monitoring of Mycophenolate Mofetil (MMF/CellCept) After Kidney Transplantation Completed NCT00087581 Phase 4 Mycophenolate mofetil;Cyclosporine;Tacrolimus
45 Efficacy and Safety of Galantamine for Improving Dysfunction in People With Bipolar Disorder Completed NCT00741598 Phase 4 Galantamine-ER;Galantamine placebo
46 Comparison of a Needle-free Injection Method With a Needle-syringe Injection Method Completed NCT00990340 Phase 4
47 A Study to Evaluate the Efficacy and Safety of Zenapax in Combination With CellCept, Cyclosporine, and Corticosteroids in Patients Undergoing Cardiac Transplantation Completed NCT00048165 Phase 4 Daclizumab;Methylprednisolone;Mycophenolate mofetil;Placebo;cyclosporine
48 Trachoma Amelioration in Northern Amhara (TANA) Completed NCT00322972 Phase 4 Mass treatment with oral azithromycin to an entire community
49 Oral Glutamine in Cardiopulmonary Bypass Completed NCT02491931 Phase 4
50 Study To Investigate The Hemodynamic Effects Of Single Dose Vardenafil In Subjects Receiving Maraviroc Completed NCT00853840 Phase 4 Maraviroc;Vardenafil;Maraviroc;Placebo

Search NIH Clinical Center for Asthma-Related Traits 1

Genetic Tests for Asthma-Related Traits 1

Genetic tests related to Asthma-Related Traits 1:

# Genetic test Affiliating Genes
1 Asthma-Related Traits, Susceptibility to, 1 29 PTGDR

Anatomical Context for Asthma-Related Traits 1

MalaCards organs/tissues related to Asthma-Related Traits 1:

41
Breast, Lung, Testes, Prostate, Bone, Skin, Liver

Publications for Asthma-Related Traits 1

Articles related to Asthma-Related Traits 1:

# Title Authors Year
1
A 47-year-old woman with severe asthma, 1 year later. ( 11466125 )
2001
2
Adherence and compliance in the management of asthma: 1. ( 10076205 )
1998
3
Practical aspects of aerosol therapy in asthma (1) ( 9141764 )
1996
4
Asthma: 1. Pathophysiologic features and evaluation of severity. ( 3815196 )
1987
5
Duration of the development stages of house dust mites Dermatophagoides farinae and D. pteronyssinus under controlled temperatures and relative humidities to pave the way in front of the workers in the field of house-dust mite bronchial asthma. 1. Pre-imaginal period. ( 6663096 )
1983
6
Management of asthma. 1. Approach. ( 854495 )
1977
7
Acute respiratory failure due to asthma. 1. Pathophysiology. ( 5566205 )
1971

Variations for Asthma-Related Traits 1

ClinVar genetic disease variations for Asthma-Related Traits 1:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 PTGDR PTGDR, HAPLOTYPE TCT undetermined variant risk factor
2 PTGDR PTGDR, HAPLOTYPE CCC undetermined variant risk factor

Expression for Asthma-Related Traits 1

Search GEO for disease gene expression data for Asthma-Related Traits 1.

Pathways for Asthma-Related Traits 1

GO Terms for Asthma-Related Traits 1

Sources for Asthma-Related Traits 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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