ASRT1
MCID: AST055
MIFTS: 34

Asthma-Related Traits 1 (ASRT1)

Categories: Genetic diseases, Immune diseases, Skin diseases

Aliases & Classifications for Asthma-Related Traits 1

MalaCards integrated aliases for Asthma-Related Traits 1:

Name: Asthma-Related Traits 1 58 76
Asthma-Related Traits, Susceptibility to, 1 58 30 6 74
Asthma, Susceptibility to, 1 58 13
Asrt1 58 76
Asthma-Related Traits, Susceptibility to, Type 1 41
Asthma 1 58
As1 58

Classifications:



External Ids:

OMIM 58 607277
MeSH 45 D001249
MedGen 43 C1846534
UMLS 74 C1846534

Summaries for Asthma-Related Traits 1

OMIM : 58 Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, and dyspnea; bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test; serum IgE levels; atopy; and atopic dermatitis (Laitinen et al., 2001; Illig and Wjst, 2002; Pillai et al., 2006). For a general phenotypic description and a discussion of genetic heterogeneity of asthma, see 600807. (607277)

MalaCards based summary : Asthma-Related Traits 1, also known as asthma-related traits, susceptibility to, 1, is related to colorectal cancer and hepatocellular carcinoma. An important gene associated with Asthma-Related Traits 1 is PTGDR (Prostaglandin D2 Receptor). The drugs Bupivacaine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and testes.

UniProtKB/Swiss-Prot : 76 Asthma-related traits 1: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.

Related Diseases for Asthma-Related Traits 1

Diseases in the Asthma-Related Traits 1 family:

Asthma-Related Traits 2 Asthma-Related Traits 3
Asthma-Related Traits 4 Asthma-Related Traits 5
Asthma-Related Traits 6 Asthma-Related Traits 7
Asthma-Related Traits 8

Diseases related to Asthma-Related Traits 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 colorectal cancer 10.1
2 hepatocellular carcinoma 10.1
3 small cell cancer of the lung 10.1
4 lung cancer 10.1
5 osteogenic sarcoma 10.1
6 cervical cancer 10.1
7 squamous cell carcinoma 10.1
8 asthma 10.1
9 bladder cancer 10.0
10 ovarian cancer 10.0
11 thyroid cancer, nonmedullary, 1 10.0
12 gastric cancer 10.0
13 inflammatory bowel disease 10.0
14 thyroid cancer 10.0
15 hypoxia 10.0
16 respiratory failure 9.7

Graphical network of the top 20 diseases related to Asthma-Related Traits 1:



Diseases related to Asthma-Related Traits 1

Symptoms & Phenotypes for Asthma-Related Traits 1

Clinical features from OMIM:

607277

Drugs & Therapeutics for Asthma-Related Traits 1

Drugs for Asthma-Related Traits 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 974)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4,Phase 2,Not Applicable 38396-39-3, 2180-92-9 2474
2
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 62-31-7, 51-61-6 681
3
Olanzapine Approved, Investigational Phase 4,Phase 3 132539-06-1 4585
4
Oxcarbazepine Approved Phase 4,Phase 3 28721-07-5 34312
5
Valproic Acid Approved, Investigational Phase 4,Phase 3 99-66-1 3121
6
Coal tar Approved Phase 4,Phase 1 8007-45-2
7
Lithium carbonate Approved Phase 4,Phase 3 554-13-2
8
Ziprasidone Approved Phase 4,Early Phase 1 146939-27-7 60854
9
Tramadol Approved, Investigational Phase 4,Phase 1 27203-92-5 33741
10
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
11
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 5311068 68602
12
Aprepitant Approved, Investigational Phase 4 170729-80-3 6918365 151165
13
Fosaprepitant Approved Phase 4 172673-20-0 219090
14
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 1177-87-3
15
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
16
Tropisetron Approved, Investigational Phase 4 105826-92-4, 89565-68-4 5595
17
Gefitinib Approved, Investigational Phase 4,Phase 3,Phase 2 184475-35-2 123631
18
Rocuronium Approved Phase 4,Not Applicable 119302-91-9, 143558-00-3 441290
19
Ropivacaine Approved Phase 4,Phase 1,Phase 2,Not Applicable 84057-95-4 175805 71273
20
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 1 185243-69-0
21
Morphine Approved, Investigational Phase 4,Phase 1,Phase 2 57-27-2 5288826
22
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
23
Clarithromycin Approved Phase 4,Phase 3,Phase 2,Not Applicable 81103-11-9 84029
24
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 26787-78-0 33613
25
Ofloxacin Approved Phase 4,Phase 2,Phase 3 82419-36-1 4583
26
Metronidazole Approved Phase 4,Phase 3,Phase 2 443-48-1 4173
27
Levofloxacin Approved, Investigational Phase 4,Phase 2,Phase 3 100986-85-4 149096
28
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
29
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1 75607-67-9, 21679-14-1 30751
30
rituximab Approved Phase 4,Phase 3,Phase 2 174722-31-7 10201696
31
Vidarabine Approved, Investigational Phase 4,Phase 2,Phase 1 24356-66-9 21704 32326
32
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
33
Travoprost Approved Phase 4 157283-68-6 5282226
34
Timolol Approved Phase 4 26839-75-8 5478 33624
35
Bimatoprost Approved, Investigational Phase 4,Phase 2 155206-00-1 5311027
36
tannic acid Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 1401-55-4
37
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 1994-09-7, 94-09-7 2337
38
Doripenem Approved, Investigational Phase 4 148016-81-3 73303
39
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 137-58-6 3676
40
Tetracycline Approved, Vet_approved Phase 4,Phase 3 60-54-8 5353990
41
Tigecycline Approved Phase 4 220620-09-7 5282044
42
Cilastatin Approved, Investigational Phase 4 82009-34-5 6435415 5280454
43
Imipenem Approved Phase 4 64221-86-9, 74431-23-5 104838
44
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 51-45-6 774
45
Dimenhydrinate Approved Phase 4 523-87-5 441281
46
Desoximetasone Approved Phase 4 382-67-2 5311067
47
Donepezil Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 120014-06-4 3152
48
Olodaterol Approved Phase 4 868049-49-4
49
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
50
Certolizumab pegol Approved Phase 4,Phase 3 428863-50-7

Interventional clinical trials:

(show top 50) (show all 1099)
# Name Status NCT ID Phase Drugs
1 Dose Finding Study for Continuous Spinal Anaesthesia Unknown status NCT01680120 Phase 4
2 Comparative Efficacy and Acceptability of Antimanic Drugs in Acute Mania Unknown status NCT01893229 Phase 4 Lithium;Valproate;Oxcarbazepine;Quetiapine;Olanzapine;Ziprasidone
3 Prospective Analysis of Value of Contrast-enhanced Sonography During Biopsies of Focal Liver Masses Unknown status NCT03040323 Phase 4 Lumason 60.7Mg Powder for Injection;Placebos
4 Single Dose Tramadol Effect on Extubation Response and Quality of Emergence Post-supratentorial Intracranial Surgery Unknown status NCT02964416 Phase 4 Injection Tramadol
5 Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty Unknown status NCT01934049 Phase 4 Total Intravenous Anesthesia and Peripheral nerve blocks
6 A Study Evaluating the Efficacy and Safety of Aprepitant in Autologous Hematopoietic Stem Cell Transplantation Unknown status NCT02576327 Phase 4 Tropisetron;Dexamethasone;Aprepitant
7 Efficacy of High Dose Dual Therapy, Sequential Therapy and Triple Therapy in H. Pylori Eradication Completed NCT01163435 Phase 4 high dose dual therapy;sequential therapy;clarithromycin-based triple therapy;levofloxacin-based triple therapy
8 Efficacy, Safety, Tolerability of Gefitinib as 1st Line in Caucasian Patients With EGFR Mutation Positive Advanced NSCLC Completed NCT01203917 Phase 4 Gefitinib
9 Efficacy Response Duration and Toxicity of Rituximab, Fludarabine, and Cyclophosphamide (RFC) as 1st Line Treatment and Rituximab (R) in Maintenance Treatment in Follicular Non Hodgkin (FNH) Lymphoma Completed NCT01124526 Phase 4 Rituximab Fludarabine Cyclophosphamide
10 Safety and Efficacy of LUMIGAN® RC Versus DuoTrav® in Patients Who Require Further Intraocular Pressure (IOP) Reduction Completed NCT01547598 Phase 4 travoprost ophthalmic solution 0.004%;travoprost 0.004% / timolol 0.5% combination ophthalmic solution;Bimatoprost ophthalmic solution 0.01%
11 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Enrolling by invitation NCT02812186 Phase 4 Rocuronium
12 A Safety and Efficacy Study of Doripenem in Participants With Nosocomial Pneumonia, Complicated Intra-Abdominal Infections and Urinary Tract Infections Completed NCT00965848 Phase 4 Doripenem
13 Adjuvant to General Anesthesia in Patients Undergoing Major Abdominal Surgeries Not yet recruiting NCT03600493 Phase 4 Dexmedetomidine;Lidocaine
14 Efficacy of High-dose Dual Therapy vs Bismuth-containing Quadruple Therapy for First-line Treatment of Hp Infection Completed NCT02483715 Phase 4 High-dose dual therapy (rabeprazole, amoxicillin);Bismuth-containing quadruple therapy (rabeprazole, tripotassium dicitrate bismuthate, metronidazole, tetracycline)
15 A Study To Determine The Efficacy And Safety Of Tigecycline Compared With Imipenem/Cliastatin to Treat Complicated Intra-Abdominal Infection Completed NCT01721408 Phase 4 Tigecycline;Imipenem/cilastatin
16 A Trial Comparing the Effect of Oral Dimenhydrinate Versus Placebo in Children With Gastroenteritis Completed NCT00124787 Phase 4 Dimenhydrinate;Placebo
17 Topical Psoriasis Study for Patients Receiving Biologic Therapy Completed NCT02983981 Phase 4 Topicort Topical Spray
18 Cerebrolysin Compared to Donepezil in Patients With Mild to Moderate Dementia of Alzheimer's Type (DAT) Withdrawn NCT01822951 Phase 4 Cerebrolysin;Donepezil
19 Catheter Ablation of Atrial Fibrillation Using Hansen Medical Robotic Navigation Terminated NCT01037296 Phase 4
20 Ropivacaine Use Intraincisionally Versus Intraperitoneally for Post-Laparoscopic Cholecystectomy Pain Completed NCT03265223 Phase 4 0.2% ropivacaine
21 Abdominal Belt Use to Treat Low Back Pain Completed NCT02062918 Phase 4
22 An Efficacy Study of Umeclidinium/Vilanterol With Tiotropium/Olodaterol in COPD Patients Completed NCT02799784 Phase 4 UMEC/VI;TIO/OLO;Albuterol/salbutamol
23 Titration of Intravenous Hydromorphone Completed NCT01892709 Phase 4 Hydromorphone
24 Mechanistic Studies of B- and T-Cell Function in RA Patients Treated With TNF Antagonists, Tocilizumab, or Abatacept Recruiting NCT02353780 Phase 4 TNF Antagonist (enbrel, humire, remicade, cimzia, symponi);Abatacept;Tocilizumab
25 Evaluation of Patient Reported Outcomes in RRMS Patients Candidates for MS Therapy Change and Transitioned to Fingolimod 0.5 mg (EPOC) Completed NCT01534182 Phase 4 Fingolimod;Interferon beta - 1a (IFN);Glatiramer acetate (GA)
26 Evaluation of Dexmedetomidine on Post-operative Narcotic Requirements and Pain Scores in Bariatric Patients Completed NCT02604940 Phase 4 Dexmedetomidine;Normal Saline
27 TRUST-2: Safety and Efficacy of Intravenous Remodulin® in Patients in India With Pulmonary Arterial Hypertension (PAH) Completed NCT03055221 Phase 4 Intravenous Treprostinil
28 Tropical Influenza Control Strategies for the Elderly Completed NCT02655874 Phase 4
29 Use of Apremilast in Patients Who Are Dissatisfied With Stable Maintenance Topical Therapy Completed NCT03000309 Phase 4 Apremilast
30 Evaluation of Quality of Life (QoL) in Subjects With Highly Active Relapsing Multiple Sclerosis (MS) Recruiting NCT03369665 Phase 4 Mavenclad®
31 Evaluation of the Onset of Action in Highly Active Multiple Sclerosis (MS) Recruiting NCT03364036 Phase 4 Mavenclad®
32 Effect of Preoperative Estrogen Treatment on Connective Tissues of the Pelvic Floor Completed NCT01778985 Phase 4 Premarin
33 Repository Corticotropin Injection To Treat Rheumatoid Arthritis Patients Who Have Failed Three Biologic Therapies. Completed NCT01966718 Phase 4 Repository corticotropin injection
34 Safety and Efficacy of Adding AZARGA® Adjunctive to Prostaglandin Therapy Completed NCT01263444 Phase 4 Brinzolamide 1% / timolol 0.5% Fixed Combination;Habitual prostaglandin monotherapy
35 Use of Mobile Devices and the Internet to Streamline an Asthma Clinical Trial Completed NCT02061280 Phase 4 fluticasone/salmeterol 250/50 Dry Powder Inhaler;fluticasone/salmeterol 100/50 Dry Powder Inhaler;fluticasone 100mcg Dry Powder Inhaler
36 Effectiveness, Safety and Immunogenicity of GSK Biologicals' HPV Vaccine GSK580299 (Cervarix TM) Administered in Healthy Adolescents Completed NCT00534638 Phase 4
37 Study Assessing Patient Satisfaction With LATISSE® for Increasing Eyelash Prominence Completed NCT01448525 Phase 4 bimatoprost ophthalmic solution 0.03%;bimatoprost vehicle solution
38 A 6-month, Randomized, Open-label, Patient OutComes, Safety and Tolerability Study of Fingolimod (FTY720) 0.5 mg/Day vs. Comparator in Patients With Relapsing Forms of Multiple Sclerosis Completed NCT01216072 Phase 4 Fingolimod;Standard MS DMTs
39 Study of Catheter-related Infections Using Antibiotic-coated Versus Conventional Catheters in Children Terminated NCT00370149 Phase 4
40 The Effects of ADHD Medication (TEAM) Study Recruiting NCT02293655 Phase 4 OROS-Methylphenidate (MPH)
41 Memantine and Cognitive Dysfunction in Bipolar Disorder Completed NCT00586066 Phase 4 Memantine;Placebo
42 Use of Pulsed Electromagnetic Fields (PEMF) After Breast Reconstruction Surgery Completed NCT01262599 Phase 4
43 Evaluation of the Tubular Effects of Dapagliflozin Using 1HNMR Spectroscopy Completed NCT02798757 Phase 4 Dapagliflozin
44 Care Path for the Management of Ulcerative Colitis Terminated NCT01882426 Phase 4
45 Relative Bioavailability Study of Zoloft Oral Solution to Zoloft Tablets Completed NCT03711708 Phase 4 Zoloft Oral Solution;Zoloft tablets
46 A 6 Month Safety Study Of Ciclesonide Nasal Aerosol (Zetonna®) And Ciclesonide Nasal Spray (Omnaris®) In Subjects 12 Years And Older With Perennial Allergic Rhinitis (PAR) Completed NCT01654536 Phase 4 ciclesonide nasal aerosol;ciclesonide nasal spray
47 Efficacy of Artesunate-amodiaquine and Artemether-lumefantrine for Uncomplicated Malaria in South Kivu, DR Congo Completed NCT02741024 Phase 4 Amodiaquine-Artesunate (ASAQ);Artemether-Lumefantrine (AL)
48 Safety and Efficacy of OsmoPrep® Tablets Versus HalfLytely® and Bisacodyl Tablet Bowel Prep Kit for Colon Cleansing Completed NCT01427296 Phase 4 Polyethylene glycol;Oral sodium phosphate solution
49 Assessment Of Dutasteride (AVODART) In Extending The Time To Progression Of Low-Risk, Localized Prostate Cancer In Men Completed NCT00363311 Phase 4 Dutasteride;Matching placebo
50 Long-term Oral Esomeprazole for Prevention of Peptic Ulcer Rebleeding in High-risk Patients Recruiting NCT02456012 Phase 4 oral esomeprazole 20 mg twice daily;oral esomeprazole 20 mg once daily

Search NIH Clinical Center for Asthma-Related Traits 1

Genetic Tests for Asthma-Related Traits 1

Genetic tests related to Asthma-Related Traits 1:

# Genetic test Affiliating Genes
1 Asthma-Related Traits, Susceptibility to, 1 30 PTGDR

Anatomical Context for Asthma-Related Traits 1

MalaCards organs/tissues related to Asthma-Related Traits 1:

42
Breast, Lung, Testes, Prostate, Bone, Liver, Eye

Publications for Asthma-Related Traits 1

Articles related to Asthma-Related Traits 1:

(show all 11)
# Title Authors Year
1
Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial. ( 30416083 )
2018
2
Asthma 1-2-3: a low literacy multimedia tool to educate African American adults about asthma. ( 19353250 )
2009
3
Role of prostanoid DP receptor variants in susceptibility to asthma. ( 15496624 )
2004
4
A 47-year-old woman with severe asthma, 1 year later. ( 11466125 )
2001
5
Adherence and compliance in the management of asthma: 1. ( 10076205 )
1998
6
Steroid-sparing drugs in steroid-dependent asthma: 1-cyclosporin-A. ( 9510676 )
1997
7
Practical aspects of aerosol therapy in asthma (1) ( 9141764 )
1996
8
Asthma: 1. Pathophysiologic features and evaluation of severity. ( 3815196 )
1987
9
Duration of the development stages of house dust mites Dermatophagoides farinae and D. pteronyssinus under controlled temperatures and relative humidities to pave the way in front of the workers in the field of house-dust mite bronchial asthma. 1. Pre-imaginal period. ( 6663096 )
1983
10
Management of asthma. 1. Approach. ( 854495 )
1977
11
Acute respiratory failure due to asthma. 1. Pathophysiology. ( 5566205 )
1971

Variations for Asthma-Related Traits 1

ClinVar genetic disease variations for Asthma-Related Traits 1:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 PTGDR PTGDR, HAPLOTYPE TCT undetermined variant risk factor
2 PTGDR PTGDR, HAPLOTYPE CCC undetermined variant risk factor

Expression for Asthma-Related Traits 1

Search GEO for disease gene expression data for Asthma-Related Traits 1.

Pathways for Asthma-Related Traits 1

GO Terms for Asthma-Related Traits 1

Sources for Asthma-Related Traits 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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