ASRT2
MCID: AST056
MIFTS: 28

Asthma-Related Traits 2 (ASRT2)

Categories: Genetic diseases, Immune diseases, Skin diseases

Aliases & Classifications for Asthma-Related Traits 2

MalaCards integrated aliases for Asthma-Related Traits 2:

Name: Asthma-Related Traits 2 57 73
Asthma-Related Traits, Susceptibility to, 2 57 29 6 71
Asthma, Susceptibility to, 2 57 13
Asrt2 57 73
Asthma-Related Traits, Susceptibility to, Type 2 39
Asthma 2 57

Classifications:



External Ids:

OMIM® 57 608584
MeSH 44 D001249
MedGen 41 C1837811
UMLS 71 C1837811

Summaries for Asthma-Related Traits 2

OMIM® : 57 Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, and dyspnea; bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test; serum IgE levels; atopy; and atopic dermatitis (Laitinen et al., 2001; Illig and Wjst, 2002). For a general phenotypic description and a discussion of genetic heterogeneity of asthma, see 600807. (608584) (Updated 05-Mar-2021)

MalaCards based summary : Asthma-Related Traits 2, also known as asthma-related traits, susceptibility to, 2, is related to asthma and chronic asthma. An important gene associated with Asthma-Related Traits 2 is NPSR1 (Neuropeptide S Receptor 1). The drugs Nicotine and Carbon monoxide have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and trachea.

UniProtKB/Swiss-Prot : 73 Asthma-related traits 2: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.

Related Diseases for Asthma-Related Traits 2

Diseases in the Asthma-Related Traits 2 family:

Asthma-Related Traits 1 Asthma-Related Traits 3
Asthma-Related Traits 4 Asthma-Related Traits 5
Asthma-Related Traits 6 Asthma-Related Traits 7
Asthma-Related Traits 8

Diseases related to Asthma-Related Traits 2 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 asthma 29.3 NPSR1-AS1 NPSR1
2 chronic asthma 9.7
3 respiratory failure 9.7
4 allergic disease 9.7
5 eosinophilic pneumonia 9.7
6 chronic eosinophilic pneumonia 9.7

Graphical network of the top 20 diseases related to Asthma-Related Traits 2:



Diseases related to Asthma-Related Traits 2

Symptoms & Phenotypes for Asthma-Related Traits 2

Clinical features from OMIM®:

608584 (Updated 05-Mar-2021)

Drugs & Therapeutics for Asthma-Related Traits 2

Drugs for Asthma-Related Traits 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nicotine Approved Phase 3 54-11-5 942 89594
2
Carbon monoxide Approved, Investigational Phase 3 630-08-0 281
3
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
4 Respiratory System Agents
5 Anti-Asthmatic Agents
6 Anti-Inflammatory Agents
7 Hormone Antagonists
8 glucocorticoids
9 Hormones
10
Beclomethasone 4419-39-0 20469
11 Hypnotics and Sedatives
12 Anesthetics, Intravenous
13 Anesthetics, General
14 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sustaining Cessation in Smokers With Kids With Asthma Completed NCT00862368 Phase 3
2 Development and Validation of a Sputum Biomarker mRNA Panel for the Diagnostic Work-up of Asthma 2 Unknown status NCT01224951 Beclomethasone
3 A Pilot Stress Management Intervention for High Risk Children With Asthma Completed NCT02091648
4 Influence of Propofol on Alveolar Macrophage Immunity in Asthmatic Patients Undergoing General Anesthesia Completed NCT00676416 2,6-Diisopropylphenol

Search NIH Clinical Center for Asthma-Related Traits 2

Genetic Tests for Asthma-Related Traits 2

Genetic tests related to Asthma-Related Traits 2:

# Genetic test Affiliating Genes
1 Asthma-Related Traits, Susceptibility to, 2 29 NPSR1

Anatomical Context for Asthma-Related Traits 2

MalaCards organs/tissues related to Asthma-Related Traits 2:

40
Heart, T Cells, Trachea, Smooth Muscle, Kidney, Skin, Monocytes

Publications for Asthma-Related Traits 2

Articles related to Asthma-Related Traits 2:

(show top 50) (show all 330)
# Title Authors PMID Year
1
Characterization of a common susceptibility locus for asthma-related traits. 6 57
15073379 2004
2
The protective effect of farm animal exposure on childhood allergy is modified by NPSR1 polymorphisms. 57
18285428 2009
3
Biological and genetic interaction between tenascin C and neuropeptide S receptor 1 in allergic diseases. 57
18305139 2008
4
Physical map of an asthma susceptibility locus in 7p15-p14 and an association study of TCRG. 57
12357338 2002
5
Genetics of asthma and related phenotypes. 57
12065182 2002
6
A susceptibility locus for asthma-related traits on chromosome 7 revealed by genome-wide scan in a founder population. 57
11326283 2001
7
Importance of genetic factors in adolescent asthma: a population-based twin-family study. 57
9563721 1998
8
Telemedicine in Pediatrics: A Systematic Review of Randomized Controlled Trials. 61
33556030 2021
9
Grandmaternal smoking, asthma and lung function in the offspring: the Lifelines cohort study. 61
33542091 2021
10
Severe asthma: adding new evidence - Latin American Thoracic Society. 61
33532459 2021
11
[Smoking cessation in asthmatic patients and its impact]. 61
33414027 2021
12
The DIANA Study: Continued Access to Darunavir/Ritonavir (DRV/r) and Long-Term Safety Follow-Up in HIV-1-Infected Pediatric Patients Aged 3 to < 18 Years. 61
33367975 2020
13
A Patient-Centered Asthma Management Communication Intervention for Rural Latino Children: Protocol for a Waiting-List Randomized Controlled Trial. 61
33258784 2020
14
Prevalence and Economic Burden of Respiratory Diseases in Central Asia and Russia: A Systematic Review. 61
33066700 2020
15
Focus on asthma 2: air pollution and its effects on children and young people. 61
33073551 2020
16
Integrating Comorbidities and Phenotype-Based Medicine in Patient-Centered Medicine in COPD. 61
32854364 2020
17
Fractional Exhaled Nitric Oxide as an Inflammatory Biomarker in Chronic Obstructive Pulmonary Disease (COPD) with or without Concurrent Diagnosis of Asthma: The Canadian Cohort Obstructive Lung Disease (CanCOLD). 61
32584165 2020
18
Breathing pattern disorders (dysfunctional breathing) characteristics and outcomes of children and young people attending a secondary care respiratory clinic. 61
32449843 2020
19
Blockade of RANKL/RANK and NF-ĸB signalling pathways as novel therapeutic strategies for allergic asthma: A comparative study in a mouse model of allergic airway inflammation. 61
32339516 2020
20
Building Bridges for Asthma Care Program: A School-Centered Program Connecting Schools, Families, and Community Health-Care Providers. 61
30336726 2020
21
How does the EQ-5D-5L perform in asthma patients compared with an asthma-specific quality of life questionnaire? 61
32534568 2020
22
Short-course systemic corticosteroids in asthma: striking the balance between efficacy and safety. 61
32245768 2020
23
The Relationship Between Real-World Inhaled Corticosteroid Adherence and Asthma Outcomes: A Multilevel Approach. 61
31541763 2020
24
Impact of the Choosing Wisely® Campaign Recommendations for Hospitalized Children on Clinical Practice: Trends from 2008 to 2017. 61
31532743 2020
25
Temporary and permanent unfitness of occupational divers. Brest Cohort 2002-2019 from the French National Network for Occupational Disease Vigilance and Prevention (RNV3P). 61
32212151 2020
26
Potentially (near) fatal asthma. 61
31690380 2019
27
Responsive Asthma Care for Teens (ReACT): development protocol for an adaptive mobile health intervention for adolescents with asthma. 61
31434777 2019
28
Asthma symptoms, interactive physical play and behavioral and academic outcomes in urban children with persistent asthma. 61
29969924 2019
29
Phenotypes and endotypes of adult asthma: Moving toward precision medicine. 61
31277742 2019
30
[A bibliometric analysis of research on occupational asthma during 1998 to 2017]. 61
31256523 2019
31
Last station in the eosinophilic asthma with chronic rhinosinusitis and/or nasal polyposis march: Eosinophilic asthma with radiological findings associated with blood eosinophilia. 61
29611776 2019
32
Asthma and youth soccer: an investigation into the level of asthma awareness and training among youth soccer coaches. 61
30697089 2019
33
Identifying Barriers to Physical Activity Among African American Women with Asthma. 61
31754624 2019
34
Eosinophilic asthma, according to a blood eosinophil criterion, is associated with disease severity and lack of control among underprivileged urban Brazilians. 61
30509723 2018
35
Effect of indoor air quality on the natural history of asthma in an urban population in Poland. 61
30401330 2018
36
Mechanisms of organophosphorus pesticide toxicity in the context of airway hyperreactivity and asthma. 61
29952220 2018
37
Chinese guidelines for childhood asthma 2016: Major updates, recommendations and key regional data. 61
29227721 2018
38
Reaction products of hexamethylene diisocyanate vapors with "self" molecules in the airways of rabbits exposed via tracheostomy. 61
28489470 2018
39
Tiotropium Respimat Add-on Is Efficacious in Symptomatic Asthma, Independent of T2 Phenotype. 61
29174062 2018
40
Outdoor air pollution, exhaled 8-isoprostane and current asthma in adults: the EGEA study. 61
29618600 2018
41
Parental Perspectives of Barriers to Physical Activity in Urban Schoolchildren With Asthma. 61
29309846 2018
42
Prevalence of Asthma, Asthma Attacks, and Emergency Department Visits for Asthma Among Working Adults - National Health Interview Survey, 2011-2016. 61
29621204 2018
43
Excessive gestational weight gain in first trimester is a risk factor for exacerbation of asthma during pregnancy: A prospective study of 1283 pregnancies. 61
28551030 2018
44
Asthma-related lung function, sleep quality, and sleep duration in urban children. 61
28526251 2017
45
Airway Hyperresponsiveness in Asthma: Measurement and Clinical Relevance. 61
28163029 2017
46
Association Between Migraine and Atopic Diseases in Childhood: A Potential Protective Role of Anti-Allergic Drugs. 61
28160287 2017
47
Understanding discharge communication behaviours in a pediatric emergency care context: a mixed methods observation study protocol. 61
28412951 2017
48
Early life travelling does not increase risk of atopic outcomes until 15 years: results from GINIplus and LISAplus. 61
28122145 2017
49
Designing a physical activity intervention for children with asthma: a qualitative study of the views of healthcare professionals, parents and children with asthma. 61
28341689 2017
50
[Rating criteria for selection of an inhaler and instructing its use in patients with asthma and COPD]. 61
28024131 2016

Variations for Asthma-Related Traits 2

ClinVar genetic disease variations for Asthma-Related Traits 2:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 NPSR1-AS1 NM_207172.2(NPSR1):c.320A>T (p.Asn107Ile) SNV risk factor 2192 rs324981 7:34818113-34818113 7:34778501-34778501

Expression for Asthma-Related Traits 2

Search GEO for disease gene expression data for Asthma-Related Traits 2.

Pathways for Asthma-Related Traits 2

GO Terms for Asthma-Related Traits 2

Sources for Asthma-Related Traits 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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