ASRT2
MCID: AST056
MIFTS: 19

Asthma-Related Traits 2 (ASRT2)

Categories: Genetic diseases, Immune diseases, Skin diseases

Aliases & Classifications for Asthma-Related Traits 2

MalaCards integrated aliases for Asthma-Related Traits 2:

Name: Asthma-Related Traits 2 58 76
Asthma-Related Traits, Susceptibility to, 2 58 30 6 74
Asthma, Susceptibility to, 2 58 13
Asrt2 58 76
Asthma-Related Traits, Susceptibility to, Type 2 41
Asthma 2 58

Classifications:



External Ids:

OMIM 58 608584
MeSH 45 D001249
MedGen 43 C1837811
UMLS 74 C1837811

Summaries for Asthma-Related Traits 2

OMIM : 58 Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, and dyspnea; bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test; serum IgE levels; atopy; and atopic dermatitis (Laitinen et al., 2001; Illig and Wjst, 2002). For a general phenotypic description and a discussion of genetic heterogeneity of asthma, see 600807. (608584)

MalaCards based summary : Asthma-Related Traits 2, also known as asthma-related traits, susceptibility to, 2, is related to asthma and respiratory failure. An important gene associated with Asthma-Related Traits 2 is NPSR1 (Neuropeptide S Receptor 1). Affiliated tissues include testes and skin.

UniProtKB/Swiss-Prot : 76 Asthma-related traits 2: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.

Related Diseases for Asthma-Related Traits 2

Diseases in the Asthma-Related Traits 1 family:

Asthma-Related Traits 2 Asthma-Related Traits 3
Asthma-Related Traits 4 Asthma-Related Traits 5
Asthma-Related Traits 6 Asthma-Related Traits 7
Asthma-Related Traits 8

Diseases related to Asthma-Related Traits 2 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 asthma 10.1
2 respiratory failure 9.7

Symptoms & Phenotypes for Asthma-Related Traits 2

Clinical features from OMIM:

608584

Drugs & Therapeutics for Asthma-Related Traits 2

Search Clinical Trials , NIH Clinical Center for Asthma-Related Traits 2

Genetic Tests for Asthma-Related Traits 2

Genetic tests related to Asthma-Related Traits 2:

# Genetic test Affiliating Genes
1 Asthma-Related Traits, Susceptibility to, 2 30 NPSR1

Anatomical Context for Asthma-Related Traits 2

MalaCards organs/tissues related to Asthma-Related Traits 2:

42
Testes, Skin

Publications for Asthma-Related Traits 2

Articles related to Asthma-Related Traits 2:

# Title Authors Year
1
Asthma Action Plan Receipt among Children with Asthma 2-17 Years of Age, United States, 2002-2013. ( 26858189 )
2016
2
Asthma 2 Oral Presentations. ( 27005360 )
2016
3
Bronchial thermoplasty in asthma: 2-year follow-up using optical coherence tomography. ( 26022958 )
2015
4
Growth of preschool children at high risk for asthma 2 years after discontinuation of fluticasone. ( 21820163 )
2011
5
Characterization of a common susceptibility locus for asthma-related traits. ( 15073379 )
2004
6
Adherence and compliance in the management of asthma: 2. ( 10076216 )
1998
7
Practical aspects of aerosol therapy in asthma (2): Metered dose inhalers and spacers. ( 9164027 )
1997
8
Asthma: 2. Trends in pharmacologic therapy. ( 2880649 )
1987
9
Management of asthma. 2. Antiasthmatic drugs. ( 404636 )
1977
10
Acute respiratory failure due to asthma. 2. Diagnostic and therapeutic principles. ( 5566206 )
1971

Variations for Asthma-Related Traits 2

ClinVar genetic disease variations for Asthma-Related Traits 2:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 NPSR1 NM_207173.1(NPSR1): c.320A> T (p.Asn107Ile) single nucleotide variant risk factor rs324981 GRCh37 Chromosome 7, 34818113: 34818113
2 NPSR1 NM_207173.1(NPSR1): c.320A> T (p.Asn107Ile) single nucleotide variant risk factor rs324981 GRCh38 Chromosome 7, 34778501: 34778501

Expression for Asthma-Related Traits 2

Search GEO for disease gene expression data for Asthma-Related Traits 2.

Pathways for Asthma-Related Traits 2

GO Terms for Asthma-Related Traits 2

Sources for Asthma-Related Traits 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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