ASRT4
MCID: AST034
MIFTS: 28

Asthma-Related Traits 4 (ASRT4)

Categories: Genetic diseases, Immune diseases, Skin diseases

Aliases & Classifications for Asthma-Related Traits 4

MalaCards integrated aliases for Asthma-Related Traits 4:

Name: Asthma-Related Traits 4 57
Asthma-Related Traits, Susceptibility to, 4 57 13
Asthma and Allergic Rhinitis, Susceptibility to 57
Asthma and Allergic Rhinitis 57
Asrt4 57

Classifications:



External Ids:

OMIM® 57 610906

Summaries for Asthma-Related Traits 4

OMIM® : 57 Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, and dyspnea; bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test; serum IgE levels; atopy; and atopic dermatitis (Laitinen et al., 2001; Illig and Wjst, 2002). For a general phenotypic description and a discussion of genetic heterogeneity of asthma, see 600807, and of allergic rhinitis, see 607154. (610906) (Updated 20-May-2021)

MalaCards based summary : Asthma-Related Traits 4, also known as asthma-related traits, susceptibility to, 4, is related to allergic rhinitis and rhinitis. An important gene associated with Asthma-Related Traits 4 is ASRT4 (Asthma-Related Traits, Susceptibility To, 4). The drugs Montelukast and Fluticasone have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and t cells.

Related Diseases for Asthma-Related Traits 4

Diseases in the Asthma-Related Traits 1 family:

Asthma-Related Traits 2 Asthma-Related Traits 3
Asthma-Related Traits 4 Asthma-Related Traits 5
Asthma-Related Traits 6 Asthma-Related Traits 7
Asthma-Related Traits 8

Diseases related to Asthma-Related Traits 4 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 allergic rhinitis 11.3
2 rhinitis 11.3
3 asthma 11.0
4 allergic asthma 10.8
5 dermatitis 10.7
6 ige responsiveness, atopic 10.7
7 allergic disease 10.6
8 dermatitis, atopic 10.6
9 pollen allergy 10.5
10 food allergy 10.5
11 acute asthma 10.3
12 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.2
13 pulmonary disease, chronic obstructive 10.2
14 exanthem 10.2
15 respiratory allergy 10.2
16 chronic asthma 10.2
17 exercise-induced bronchoconstriction 10.2
18 urticaria 10.2
19 conjunctivitis 10.2
20 lung disease 10.2
21 irritable bowel syndrome 10.2
22 fibrosis of extraocular muscles, congenital, 1 10.1
23 hashimoto thyroiditis 10.1
24 migraine with or without aura 1 10.1
25 rheumatoid arthritis 10.1
26 celiac disease 1 10.1
27 immune deficiency disease 10.1
28 proteasome-associated autoinflammatory syndrome 1 10.1
29 body mass index quantitative trait locus 11 10.1
30 body mass index quantitative trait locus 9 10.1
31 body mass index quantitative trait locus 8 10.1
32 body mass index quantitative trait locus 4 10.1
33 body mass index quantitative trait locus 10 10.1
34 body mass index quantitative trait locus 7 10.1
35 body mass index quantitative trait locus 12 10.1
36 body mass index quantitative trait locus 14 10.1
37 leukemia, acute lymphoblastic 10.1
38 body mass index quantitative trait locus 18 10.1
39 body mass index quantitative trait locus 19 10.1
40 intermittent asthma 10.1
41 occupational asthma 10.1
42 bacterial infectious disease 10.1
43 klippel-feil syndrome 10.1
44 pre-eclampsia 10.1
45 respiratory failure 10.1
46 toxic shock syndrome 10.1
47 agammaglobulinemia 10.1
48 bronchiolitis 10.1
49 palmoplantar keratosis 10.1
50 skin disease 10.1

Graphical network of the top 20 diseases related to Asthma-Related Traits 4:



Diseases related to Asthma-Related Traits 4

Symptoms & Phenotypes for Asthma-Related Traits 4

Clinical features from OMIM®:

610906 (Updated 20-May-2021)

Drugs & Therapeutics for Asthma-Related Traits 4

Drugs for Asthma-Related Traits 4 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Montelukast Approved Phase 4 158966-92-8 5281040
2
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
3
Azelastine Approved Phase 4 58581-89-8 2267
4
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
5 Hormones Phase 4
6 Hormone Antagonists Phase 4
7 Leukotriene Antagonists Phase 4
8 Respiratory System Agents Phase 4
9 Anti-Asthmatic Agents Phase 4
10 Anti-Inflammatory Agents Phase 4
11 Neurotransmitter Agents Phase 4
12 Histamine H1 Antagonists, Non-Sedating Phase 4
13 Histamine Antagonists Phase 4
14
Histamine Phosphate Phase 4 51-74-1 65513
15 Dermatologic Agents Phase 4
16 Anti-Allergic Agents Phase 4
17 Bronchodilator Agents Phase 4
18 Histamine H1 Antagonists Phase 4
19 Pharmaceutical Solutions Phase 2
20
Hydrocortisone Approved, Vet_approved 50-23-7 5754
21
Hydrocortisone acetate Approved, Vet_approved 50-03-3
22
Nitric Oxide Approved 10102-43-9 145068
23 glucocorticoids
24 Hydrocortisone 17-butyrate 21-propionate
25 Hydrocortisone hemisuccinate
26
Beclomethasone 4419-39-0 20469

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Role of Montelukast in Asthma and Allergic Rhinitis Patients Completed NCT03380975 Phase 4 Montelukast 10mg
2 An 8 Week Study to Evaluate the Effectiveness of Adding Montelukast to Inhaled Corticosteroid (ICS) to the ICS/Long-Acting Beta 2-Agonist Therapy in Adult Subjects With Asthma and Allergic Rhinitis Completed NCT00545844 Phase 4 montelukast sodium
3 Proof of Concept Study to Assess Downstream Effects of Using Combined Intranasal Fluticasone Propionate Plus Azelastine Nasal Spray on Asthmatic Inflammation in Patients With Persistent Asthma and Allergic Rhinitis Terminated NCT02953106 Phase 4 Azelastine-Fluticasone Nasal;Placebos
4 A Multicenter, Double-Blind, Randomized, Crossover Study Investigating the Clinical Effect of Montelukast in Patients With Concomitant Asthma and Allergic Rhinitis Upon Controlled Exposure to Cat Allergen Completed NCT00092105 Phase 3 MK0476, montelukast sodium;Comparator: placebo
5 Efficacy and Safety of HCP1102 Capsule : A Randomized, Double-blind, Active-controlled, Multicenter Phase 3 Clinical Trial Completed NCT02552667 Phase 3 HCP1102+HGP0711Placebo;HCP1102Placebo+HGP0711
6 A Randomized, Double Blind, Placebo-controlled Study to Investigate the Safety, Pharmacodynamics and Effect on Allergic Reactivity of Repeat Intranasal Administration of the TLR7 Agonist GSK2245035 in Subjects With Respiratory Allergies Completed NCT01788813 Phase 2 GSK2245035;Placebo
7 A Randomized, Open-label, Single-Dose, 2-Treatment, 2-Way, 2-Period Crossover Study to Compare the Safety and the Pharmacokinetic Characteristics of MKT-N2 (Montelukast) and Singulair® (Montelukast Sodium) Tablet 10mg in Healthy Male Korean Subjects Completed NCT02029313 Phase 1 Montelukast;Montelukast sodium
8 Study of the Frequency and of the Regulatory Function of Positive T Lymphocytes Dual CD4CD8aa (DP8a) Specific to a Bacteria of the Intestinal Microbiota (Faecalibacterium Prausnitzii) in Atopic Dermatitis, Asthma and Allergic Rhinitis Unknown status NCT02908360
9 Evaluation of Hair Cortisol in Patients With Asthma or Allergic Rhinitis Treated With Topical (Inhaled or Intranasal) Corticosteroids Unknown status NCT01839851 Treatment with any inhaled corticosteroid;Treatment with any intranasal glucocorticoid
10 CARATKids: Italian Validation of Asthma and Allergic Rhinitis Control Test in Children Completed NCT02409550
11 The Effect of Allergen Immunotherapy on Exhaled Nitric Oxide in Adult Patients With Asthma and Allergic Rhinitis Completed NCT01318954
12 RAPP-children, Rhinitis & Asthma in Patient Perspective: Development and Validation of a Questionnaire for Quality of Life Evaluation in Children With Asthma and Allergic Rhinitis Completed NCT03276416
13 Longitudinal Observational Study in Prematurely Born Preschool Children: Assessment of Lung Function Parameters (PRE-AR) (PREMATURELY BORN CHILDREN- ASTHMA AND ALLERGIC RHINITIS ) Active, not recruiting NCT02636933

Search NIH Clinical Center for Asthma-Related Traits 4

Genetic Tests for Asthma-Related Traits 4

Anatomical Context for Asthma-Related Traits 4

MalaCards organs/tissues related to Asthma-Related Traits 4:

40
Skin, Lung, T Cells, Monocytes, Pituitary, Neutrophil, Heart

Publications for Asthma-Related Traits 4

Articles related to Asthma-Related Traits 4:

(show top 50) (show all 1146)
# Title Authors PMID Year
1
Evidence for a locus in 1p31 region specifically linked to the co-morbidity of asthma and allergic rhinitis in the EGEA study. 61 57
17310125 2007
2
Genetics of asthma and related phenotypes. 57
12065182 2002
3
Atopic dermatitis: new insight into the etiology, pathogenesis, diagnosis and novel treatment strategies. 61
33645388 2021
4
What are the health and socioeconomic impacts of allergic respiratory disease in Tasmania? 61
33789077 2021
5
Atopic Dermatitis and Sensitisation to Molecular Components of Alternaria, Cladosporium, Penicillium, Aspergillus, and Malassezia-Results of Allergy Explorer ALEX 2. 61
33806376 2021
6
Psychological impact of the COVID-19 pandemic on patients with allergic diseases. 61
33520081 2021
7
Incidence and timing of offspring asthma, wheeze, allergic rhinitis, atopic dermatitis, and food allergy and association with maternal history of asthma and allergic rhinitis. 61
33767802 2021
8
Interleukin-1 receptor-associated kinase-4 gene variation may increase post-bronchiolitis asthma risk. 61
33020954 2021
9
Question 6: What is the use of allergy testing in children with asthma? 61
32981859 2021
10
Prevention and Management with Pro-, Pre and Synbiotics in Children with Asthma and Allergic Rhinitis: A Narrative Review. 61
33799367 2021
11
The effect of Co-Q10 on allergic rhinitis and allergic asthma. 61
33743807 2021
12
Coronavirus disease 2019 and asthma, allergic rhinitis: molecular mechanisms and host-environmental interactions. 61
33186186 2021
13
IL17RA variations showed no associations with post-bronchiolitis asthma or lung function. 61
32654355 2021
14
Increased nasal mucosal interferon and CCL13 response to a TLR7/8 agonist in asthma and allergic rhinitis. 61
32717253 2021
15
Evaluation of bronchial challenge test results for use in assessment of paediatric eczema: a retrospective series. 61
33542157 2021
16
Unsupervised modeling and genome-wide association identify novel features of allergic march trajectories. 61
32650023 2021
17
Association between Physical Activity and Respiratory Diseases in Adolescents: An Age- and Gender-Matched Study. 61
33546335 2021
18
The immunomodulatory potentials of interleukin-27 in airway allergies. 61
32797730 2021
19
Maternal and childhood exposure to inorganic arsenic and airway allergy - A 15-Year birth cohort follow-up study. 61
33161204 2021
20
Eosinophilic gastrointestinal disorders and allergen immunotherapy: Lights and shadows. 61
33503273 2021
21
Prescribing patterns of medication for respiratory diseases - cluster analysis of the Portuguese electronic prescription database. 61
33415963 2021
22
Asymptomatic coronary aneurysms in a patient with eosinophilic granulomatosis with polyangiitis who developed a digital gangrene. 61
32791887 2021
23
Expression of proteins associated with airway fibrosis differs between children with allergic asthma and allergic rhinitis. 61
33626956 2021
24
Asthma and allergic rhinitis among young parents in China in relation to outdoor air pollution, climate and home environment. 61
32882555 2021
25
Beneficial effect of nasal saline irrigation in children with allergic rhinitis and asthma: A randomized clinical trial. 61
31012599 2020
26
Evaluation of Fractional Exhaled Nitric Oxide in Pediatric Asthma and Allergic Rhinitis. 61
33374635 2020
27
Socioeconomic-related determinants of asthma in the elderly. 61
33628964 2020
28
Long-term trends of asthma, allergic rhinitis and atopic eczema in young Finnish men: a retrospective analysis, 1926-2017. 61
32764114 2020
29
Adult-onset eosinophilic airway diseases. 61
33040364 2020
30
The Antiasthma Medication Ciclesonide Suppresses Breast Cancer Stem Cells through Inhibition of the Glucocorticoid Receptor Signaling-Dependent YAP Pathway. 61
33352739 2020
31
Zafirlukast prevented ox-LDL-induced formation of foam cells. 61
33096109 2020
32
Improved Bioavailability of Montelukast through a Novel Oral Mucoadhesive Film in Humans and Mice. 61
33374646 2020
33
Sex differences in group 2 innate lymphoid cell-dominant allergic airway inflammation. 61
33096416 2020
34
Residing near allergenic trees can increase risk of allergies later in life: LISA Leipzig study. 61
32853665 2020
35
Eating fish and fruits are associated with lower prevalence of allergic diseases. 61
32492630 2020
36
Comparison of serum eosinophil-derived neurotoxin levels between wheezing and non-wheezing groups in children with respiratory tract infection. 61
31298976 2020
37
Prevalence of asthma, allergic rhinitis and pollinosis in a city of Brazil: A monitoring study. 61
32439146 2020
38
Role of Montelukast in Asthma and Allergic rhinitis patients. 61
33235567 2020
39
Physiopathologie de la dermatite atopique et des autres maladies atopiques : une approche globale est-elle possible ?: Pathophysiology of atopic dermatitis and other atopic diseases: is a global approach possible? 61
33250137 2020
40
Eosinophil microRNAs Play a Regulatory Role in Allergic Diseases Included in the Atopic March. 61
33260893 2020
41
Atopic dermatitis: Correlation of severity with allergic sensitization and eosinophilia. 61
33109308 2020
42
Familial aggregation of atopic dermatitis and co-aggregation of allergic diseases in affected families in Taiwan. 61
32873424 2020
43
Effects of sublingual-specific immunotherapy on pulmonary function and exhaled nitric oxide levels in asthmatic children with and without allergic rhinitis. 61
33209732 2020
44
Medication Adherence in a Community Population with Uncontrolled Asthma. 61
33036454 2020
45
Subjective oral health status in an adult Korean population with asthma or allergic rhinitis. 61
33120860 2020
46
The association between obesity and poor outcome after COVID-19 indicates a potential therapeutic role for montelukast. 61
32492562 2020
47
Discovery of potent inhibitors for SARS-CoV-2's main protease by ligand-based/structure-based virtual screening, MD simulations, and binding energy calculations. 61
33025993 2020
48
Prevalence of sleep-disordered breathing and associated risk factors in primary school children in urban and rural environments. 61
33030645 2020
49
Allergic disorders and susceptibility to and severity of COVID-19: A nationwide cohort study. 61
32810517 2020
50
[The effectiveness and safety of subcutaneous immunotherapy for inhalable allergens in patients with respiratory allergies after one year of treatment]. 61
33631899 2020

Variations for Asthma-Related Traits 4

Expression for Asthma-Related Traits 4

Search GEO for disease gene expression data for Asthma-Related Traits 4.

Pathways for Asthma-Related Traits 4

GO Terms for Asthma-Related Traits 4

Sources for Asthma-Related Traits 4

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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