ASRT5
MCID: AST057
MIFTS: 14

Asthma-Related Traits 5 (ASRT5)

Categories: Genetic diseases, Immune diseases, Skin diseases

Aliases & Classifications for Asthma-Related Traits 5

MalaCards integrated aliases for Asthma-Related Traits 5:

Name: Asthma-Related Traits 5 58 76
Asthma-Related Traits, Susceptibility to, 5 58 30 6
Asthma Susceptibility 5 58 13
Asrt5 58 76
Asthma-Related Traits, Susceptibility to, Type 5 41

Classifications:



External Ids:

OMIM 58 611064
MeSH 45 D001249
MedGen 43 C1970224

Summaries for Asthma-Related Traits 5

OMIM : 58 Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, and dyspnea; bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test; serum IgE levels; atopy; and atopic dermatitis (Laitinen et al., 2001; Illig and Wjst, 2002; Pillai et al., 2006). For a general phenotypic description and a discussion of genetic heterogeneity of asthma, see 600807. (611064)

MalaCards based summary : Asthma-Related Traits 5, is also known as asthma-related traits, susceptibility to, 5. An important gene associated with Asthma-Related Traits 5 is IRAK3 (Interleukin 1 Receptor Associated Kinase 3). Affiliated tissues include testes and skin.

UniProtKB/Swiss-Prot : 76 Asthma-related traits 5: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.

Related Diseases for Asthma-Related Traits 5

Symptoms & Phenotypes for Asthma-Related Traits 5

Clinical features from OMIM:

611064

Drugs & Therapeutics for Asthma-Related Traits 5

Search Clinical Trials , NIH Clinical Center for Asthma-Related Traits 5

Genetic Tests for Asthma-Related Traits 5

Genetic tests related to Asthma-Related Traits 5:

# Genetic test Affiliating Genes
1 Asthma-Related Traits, Susceptibility to, 5 30 IRAK3

Anatomical Context for Asthma-Related Traits 5

MalaCards organs/tissues related to Asthma-Related Traits 5:

42
Testes, Skin

Publications for Asthma-Related Traits 5

Articles related to Asthma-Related Traits 5:

# Title Authors Year
1
IRAK-M is involved in the pathogenesis of early-onset persistent asthma. ( 17503328 )
2007

Variations for Asthma-Related Traits 5

ClinVar genetic disease variations for Asthma-Related Traits 5:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 IRAK3 NM_007199.2(IRAK3): c.227G> A (p.Trp76Ter) single nucleotide variant risk factor rs121912630 GRCh37 Chromosome 12, 66597584: 66597584
2 IRAK3 NM_007199.2(IRAK3): c.227G> A (p.Trp76Ter) single nucleotide variant risk factor rs121912630 GRCh38 Chromosome 12, 66203804: 66203804
3 IRAK3 NM_007199.2(IRAK3): c.381+1G> T single nucleotide variant risk factor GRCh37 Chromosome 12, 66603301: 66603301
4 IRAK3 NM_007199.2(IRAK3): c.381+1G> T single nucleotide variant risk factor GRCh38 Chromosome 12, 66209521: 66209521

Expression for Asthma-Related Traits 5

Search GEO for disease gene expression data for Asthma-Related Traits 5.

Pathways for Asthma-Related Traits 5

GO Terms for Asthma-Related Traits 5

Sources for Asthma-Related Traits 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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