MCID: AST002
MIFTS: 35

Astroblastoma

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Astroblastoma

MalaCards integrated aliases for Astroblastoma:

Name: Astroblastoma 12 54 60 56 15 74
Cerebral Astroblastoma 54

Characteristics:

Orphanet epidemiological data:

60
astroblastoma
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adolescent,Adult,Childhood,Infancy;

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:7305
MeSH 45 D018302
NCIt 51 C4324
SNOMED-CT 69 48952003
ICD10 via Orphanet 35 C71.9
UMLS via Orphanet 75 C0334587
Orphanet 60 ORPHA251679
UMLS 74 C0334587

Summaries for Astroblastoma

NIH Rare Diseases : 54 Astroblastoma is a rare glial tumor usually located in the cerebral hemisphere of the brain. It can occur in individuals of any age, but occurs predominantly in children and young adults. Signs and symptoms depend on the location and size of the tumor but most commonly include headaches and seizures. Because these tumors are rare, there is little known regarding their behavior and how they should be managed. Gross total resection (complete removal) of the tumor is recommended and is associated with a good prognosis for low-grade tumors. Adjuvant therapy, including radiation and/or chemotherapy, is recommended for high-grade and recurrent cases (although its effectiveness is controversial).

MalaCards based summary : Astroblastoma, also known as cerebral astroblastoma, is related to pleomorphic xanthoastrocytoma and benign ependymoma. An important gene associated with Astroblastoma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Neuroscience and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include brain, cerebellum and hypothalamus.

Wikipedia : 77 Astroblastoma is a rare glial tumor derived from the astroblast, a type of cell that closely resembles... more...

Related Diseases for Astroblastoma

Diseases related to Astroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
# Related Disease Score Top Affiliating Genes
1 pleomorphic xanthoastrocytoma 30.1 GFAP SYP
2 benign ependymoma 29.8 ENO2 GFAP SYP
3 oligodendroglioma 29.8 ENO2 GFAP SYP
4 ependymoma 28.9 ENO2 GFAP NES SYP VIM
5 status epilepticus 10.3 ENO2 GFAP
6 scrapie 10.3 ENO2 GFAP
7 neuroma 10.3 ENO2 GFAP
8 intracranial cysts 10.3 ENO2 GFAP
9 melanotic medulloblastoma 10.2 ENO2 GFAP
10 cerebellar medulloblastoma 10.2 ENO2 GFAP
11 plexiform schwannoma 10.2 ENO2 GFAP
12 myoepithelioma 10.2 GFAP VIM
13 pleomorphic adenoma 10.2 GFAP VIM
14 bednar tumor 10.2 ENO2 VIM
15 epulis 10.2 ENO2 VIM
16 ossifying fibromyxoid tumor 10.2 ENO2 VIM
17 epithelioid leiomyosarcoma 10.2 ENO2 VIM
18 leiomyosarcoma 10.2 ENO2 VIM
19 anaplastic ganglioglioma 10.2 GFAP NES
20 paraganglioma 10.2 ENO2 SYP
21 peripheral nervous system neoplasm 10.2 ENO2 SYP
22 sweat gland cancer 10.2 ENO2 SYP
23 lung benign neoplasm 10.2 ENO2 SYP
24 adrenal carcinoma 10.2 ENO2 SYP
25 merkel cell carcinoma 10.2 ENO2 SYP
26 large cell carcinoma 10.2 ENO2 SYP
27 dermatofibrosarcoma protuberans 10.2 NES VIM
28 parachordoma 10.2 GFAP VIM
29 chordoma 10.2 GFAP VIM
30 central nervous system germ cell tumor 10.2 GFAP NES
31 rhabdoid meningioma 10.2 GFAP VIM
32 syringocystadenoma papilliferum 10.2 GFAP VIM
33 traumatic brain injury 10.2 ENO2 GFAP
34 brain injury 10.2 ENO2 GFAP
35 carotid body cancer 10.2 ENO2 SYP
36 clear cell meningioma 10.2 GFAP VIM
37 atypical teratoid rhabdoid tumor 10.2 GFAP SYP
38 malignant sertoli cell tumor 10.2 ENO2 SYP
39 giant cell glioblastoma 10.2 GFAP SYP
40 myxopapillary ependymoma 10.2 GFAP VIM
41 urinary bladder small cell neuroendocrine carcinoma 10.2 ENO2 SYP
42 small cell carcinoma 10.2 ENO2 SYP
43 syringoma 10.2 GFAP VIM
44 auditory system cancer 10.2 ENO2 SYP
45 sinonasal undifferentiated carcinoma 10.2 ENO2 SYP
46 pancreatic somatostatinoma 10.1 ENO2 SYP
47 cutaneous ganglioneuroma 10.1 ENO2 SYP
48 extrahepatic bile duct adenocarcinoma 10.1 ENO2 SYP
49 small cell carcinoma of the bladder 10.1 ENO2 SYP
50 sensory organ benign neoplasm 10.1 ENO2 SYP

Graphical network of the top 20 diseases related to Astroblastoma:



Diseases related to Astroblastoma

Symptoms & Phenotypes for Astroblastoma

Drugs & Therapeutics for Astroblastoma

Search Clinical Trials , NIH Clinical Center for Astroblastoma

Genetic Tests for Astroblastoma

Anatomical Context for Astroblastoma

MalaCards organs/tissues related to Astroblastoma:

42
Brain, Cerebellum, Hypothalamus, Temporal Lobe, Parietal Lobe, Pineal, Bone

Publications for Astroblastoma

Articles related to Astroblastoma:

(show top 50) (show all 100)
# Title Authors Year
1
RBM10 truncation in astroblastoma in a patient with history of mandibular ameloblastoma: A case report. ( 30803556 )
2019
2
A case report of high-grade astroblastoma in a young adult. ( 30813777 )
2019
3
Posterior fossa astroblastoma in a child: a case report and a review of the literature. ( 30859299 )
2019
4
MN1 rearrangement in astroblastoma: study of eight cases and review of literature. ( 31111274 )
2019
5
BRAF V600E-mutated central nervous system tumor with divergent morphological feature - Anaplastic pleomorphic xanthoastrocytoma-like and astroblastoma-like. ( 30557911 )
2018
6
Astroblastoma: a distinct tumor entity characterized by alterations of the X chromosome and MN1 rearrangement. ( 28990708 )
2018
7
The use of 5-aminolevulinic acid to assist gross total resection of pediatric astroblastoma. ( 29305683 )
2018
8
Primary spinal cord astroblastoma: case report. ( 29498581 )
2018
9
Astroblastoma - a rare and challenging tumor: a case report and review of the literature. ( 29678196 )
2018
10
Patterns of care and treatment outcomes of patients with astroblastoma: a National Cancer Database analysis. ( 29708401 )
2018
11
Co-occurrence of astrocytoma and astroblastoma: Case report and literature review. ( 29939429 )
2018
12
Brainstem astroblastoma with MN1 translocation. ( 30238518 )
2018
13
Astroblastoma - reviewing literature and one case report. ( 30845307 )
2018
14
Multimodal molecular analysis of astroblastoma enables reclassification of most cases into more specific molecular entities. ( 28960623 )
2018
15
Astroblastoma in a Young Female Patient: A Case Report and Literature Review of Clinicopathological, Radiological and Prognostic Characteristics and Current Treatment Strategies. ( 29188215 )
2017
16
Erratum: A case of astroblastoma: Radiological and histopathological characteristics and a review of current treatment options. ( 29259838 )
2017
17
Patterns of care and survival outcomes in patients with astroblastoma: an individual patient data analysis of 152 cases. ( 28477040 )
2017
18
A Pediatric Tumor Found Frequently in the Adult Population: A Case of Anaplastic Astroblastoma in an Elderly Patient and Review of the Literature. ( 28239500 )
2017
19
Characterization of stem-like cells in a new astroblastoma cell line. ( 28232116 )
2017
20
Morphological and molecular features of astroblastoma, including BRAFV600E mutations, suggest an ontological relationship to other cortical-based gliomas of children and young adults. ( 27416954 )
2017
21
A case of astroblastoma: Radiological and histopathological characteristics and a review of current treatment options. ( 28144474 )
2016
22
Genomic characterization of recurrent high-grade astroblastoma. ( 27425854 )
2016
23
Astroblastoma: Case Report and Review of Literature. ( 27349390 )
2016
24
Neuroradiologic characteristics of astroblastoma and systematic review of the literature: 2 new cases and 125 cases reported in 59 publications. ( 27048363 )
2016
25
Adult intraventricular astroblastoma. ( 26831319 )
2016
26
A case of cerebral astroblastoma with rhabdoid features: a cytological, histological, and immunohistochemical study. ( 26614252 )
2016
27
Hemorrhage in astroblastoma: An unusual manifestation of an extremely rare entity. ( 26547295 )
2016
28
Distant dissemination of mixed low-grade astroblastoma-arteriovenous malformation after initial operation: a case report. ( 26261652 )
2015
29
Astroblastoma of cerebrum: A rare case report and review of literature. ( 26458709 )
2015
30
Intraventricular Astroblastoma in an Infant: A Case Report and Review of the Literature. ( 26406441 )
2015
31
Well-differentiated and anaplastic astroblastoma in the same patient: a case report and review of the literature. ( 26227256 )
2015
32
Astroblastoma: beside being a tumor entity, an occasional phenotype of astrocytic gliomas? ( 25737639 )
2015
33
Astroblastoma: rare incidence and challenges in the pattern of care. ( 24607547 )
2014
34
Astroblastoma: report of two cases with unexpected clinical behavior and review of the literature. ( 25108699 )
2014
35
High-grade astroblastoma in a child: Report of one case and review of literature. ( 25101206 )
2014
36
Cerebral astroblastoma: A radiopathological diagnosis. ( 24891904 )
2014
37
Mixed astroblastoma-arteriovenous malformation complex: a case report. ( 24005749 )
2013
38
Cerebral astroblastoma in an adult: an immunohistochemical, ultrastructural and genetic study. ( 22994361 )
2013
39
Recurrent low-grade astroblastoma with signet ring-like cells and high proliferative index. ( 23301912 )
2013
40
Cerebral astroblastoma: A case report and review of literature. ( 22870162 )
2012
41
Pediatric astroblastoma: a rare case with a review of the literature. ( 23038221 )
2012
42
Recurrent astroblastoma treated with gamma knife radiosurgery. ( 20938716 )
2011
43
A newborn with massive congenital astroblastoma. ( 21491993 )
2011
44
Clinical features and post-surgical outcome of patients with astroblastoma. ( 21507653 )
2011
45
Astroblastoma - a case report of a rare neuroepithelial tumor with complete remission after chemotherapy. ( 22011735 )
2011
46
Astroblastoma with bone invasion. ( 22347336 )
2011
47
Anaplastic astroblastoma: a rare glial tumour. ( 22679316 )
2011
48
Two cases of pediatric high-grade astroblastoma with different clinical behavior. ( 20437876 )
2010
49
Anaplastic astroblastoma-sarcoma in neurofibromatosis Type 1. ( 20860891 )
2010
50
Anaplastic astroblastoma presenting as massive, sudden-onset, intraparenchymal hemorrhage. ( 21540623 )
2010

Variations for Astroblastoma

Expression for Astroblastoma

Search GEO for disease gene expression data for Astroblastoma.

Pathways for Astroblastoma

Pathways related to Astroblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.87 ENO2 GFAP SYP
2
Show member pathways
11.17 GFAP NES VIM
3 10.82 GFAP NES SYP VIM

GO Terms for Astroblastoma

Cellular components related to Astroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell body GO:0044297 9.26 GFAP GJB2
2 intermediate filament cytoskeleton GO:0045111 9.16 GFAP NES
3 intermediate filament GO:0005882 9.13 GFAP NES VIM
4 astrocyte projection GO:0097449 8.62 GFAP GJB2

Biological processes related to Astroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron projection development GO:0010977 9.32 GFAP VIM
2 intermediate filament organization GO:0045109 9.26 GFAP VIM
3 astrocyte development GO:0014002 9.16 GFAP VIM
4 Bergmann glial cell differentiation GO:0060020 8.96 GFAP VIM
5 intermediate filament-based process GO:0045103 8.62 GFAP VIM

Molecular functions related to Astroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.26 GFAP GJB2 SYP VIM
2 structural molecule activity GO:0005198 8.8 GFAP NES VIM

Sources for Astroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....