MCID: AST002
MIFTS: 34

Astroblastoma

Categories: Bone diseases, Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Astroblastoma

MalaCards integrated aliases for Astroblastoma:

Name: Astroblastoma 12 20 58 54 15 70
Cerebral Astroblastoma 20

Characteristics:

Orphanet epidemiological data:

58
astroblastoma
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adolescent,Adult,Childhood,Infancy;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:7305
MeSH 44 D018302
NCIt 50 C4324
SNOMED-CT 67 48952003
ICD10 via Orphanet 33 C71.9
UMLS via Orphanet 71 C0334587
Orphanet 58 ORPHA251679
UMLS 70 C0334587

Summaries for Astroblastoma

GARD : 20 Astroblastoma is a rare glial tumor usually located in the cerebral hemisphere of the brain. It can occur in individuals of any age, but occurs predominantly in children and young adults. Signs and symptoms depend on the location and size of the tumor but most commonly include headaches and seizures. Because these tumors are rare, there is little known regarding their behavior and how they should be managed. Gross total resection (complete removal) of the tumor is recommended and is associated with a good prognosis for low-grade tumors. Adjuvant therapy, including radiation and/or chemotherapy, is recommended for high-grade and recurrent cases (although its effectiveness is controversial).

MalaCards based summary : Astroblastoma, also known as cerebral astroblastoma, is related to benign ependymoma and secretory meningioma. An important gene associated with Astroblastoma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Neuroscience and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include brain, cerebellum and temporal lobe.

Disease Ontology : 12 A malignant astrocytoma that is characterized by tumor cells with characteristics suggestive of an astrocytic origin (positive for GFAP), arranged perivascularly.

Wikipedia : 73 Astroblastoma is a rare glial tumor derived from the astroblast, a type of cell that closely resembles... more...

Related Diseases for Astroblastoma

Diseases related to Astroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 309)
# Related Disease Score Top Affiliating Genes
1 benign ependymoma 30.6 SYP IDH1 GFAP
2 secretory meningioma 30.3 VIM MUC1
3 pleomorphic xanthoastrocytoma 30.1 SYP IDH1 GFAP BRAF
4 gemistocytic astrocytoma 30.0 IDH1 GFAP
5 oligodendroglioma 29.9 SYP IDH1 GFAP ENO2
6 cellular ependymoma 29.9 VIM SYP NES MUC1 GFAP
7 spindle cell sarcoma 29.8 VIM MUC1 EWSR1
8 diffuse astrocytoma 29.8 IDH1 GFAP BRAF
9 hydrocephalus 29.8 SYP NES GFAP ENO2
10 anaplastic astrocytoma 29.8 NES IDH1 GFAP
11 meningioma, familial 29.8 VIM SYP MUC1 MN1 GFAP
12 malignant astrocytoma 29.8 VIM NES IDH1 GFAP BRAF
13 high grade glioma 29.7 NES IDH1 GFAP BRAF
14 gliomatosis cerebri 29.6 SYP NES IDH1 GFAP
15 ganglioglioma 29.6 SYP NES GFAP ENO2 BRAF
16 pilocytic astrocytoma 29.5 SYP NES IDH1 GFAP BRAF
17 gliosarcoma 28.9 VIM NES IDH1 GFAP ENO2 BRAF
18 astroblastoma, mn1-altered 11.3
19 glial tumor 10.5
20 rare tumor 10.4
21 papillary ependymoma 10.4 SYP GFAP
22 malignant melanocytic neoplasm of the peripheral nerve sheath 10.4 SYP ENO2
23 anal neuroendocrine tumor 10.4 SYP ENO2
24 optic nerve astrocytoma 10.4 SYP ENO2
25 neuronal intestinal dysplasia, type b 10.4 SYP ENO2
26 lung meningioma 10.4 SYP ENO2
27 auditory system benign neoplasm 10.4 SYP ENO2
28 auditory system cancer 10.4 SYP ENO2
29 cloacogenic carcinoma 10.4 SYP ENO2
30 pineal region teratoma 10.4 SYP ENO2
31 lung combined type small cell carcinoma 10.4 SYP GFAP
32 nodular prostate 10.4 SYP ENO2
33 ampulla of vater benign neoplasm 10.4 SYP ENO2
34 appendix carcinoid tumor 10.4 SYP ENO2
35 carotid body cancer 10.4 SYP ENO2
36 gallbladder small cell carcinoma 10.4 SYP ENO2
37 ureter small cell carcinoma 10.4 SYP ENO2
38 cerebellar liponeurocytoma 10.4 SYP ENO2
39 urinary bladder small cell neuroendocrine carcinoma 10.4 SYP ENO2
40 gastric small cell carcinoma 10.4 SYP ENO2
41 jejunal neoplasm 10.4 SYP ENO2
42 sensory organ benign neoplasm 10.4 SYP ENO2
43 ovarian large-cell neuroendocrine carcinoma 10.4 SYP ENO2
44 gastric hemangioma 10.4 SYP ENO2
45 myoblastoma 10.4 SYP ENO2
46 pineal parenchymal tumor of intermediate differentiation 10.4 SYP ENO2
47 cutaneous ganglioneuroma 10.4 SYP ENO2
48 chiari malformation 10.3 SYP GFAP
49 central nervous system mesenchymal non-meningothelial tumor 10.3 EWSR1 ENO2
50 cervix small cell carcinoma 10.3 SYP ENO2

Graphical network of the top 20 diseases related to Astroblastoma:



Diseases related to Astroblastoma

Symptoms & Phenotypes for Astroblastoma

Drugs & Therapeutics for Astroblastoma

Search Clinical Trials , NIH Clinical Center for Astroblastoma

Genetic Tests for Astroblastoma

Anatomical Context for Astroblastoma

MalaCards organs/tissues related to Astroblastoma:

40
Brain, Cerebellum, Temporal Lobe, Eye, Parietal Lobe, Hypothalamus, Pineal

Publications for Astroblastoma

Articles related to Astroblastoma:

(show top 50) (show all 161)
# Title Authors PMID Year
1
Semiquantitative postembedding characterization of intermediate filaments in central nervous system lesions using immunoelectron microscopy. 54 61
9044656 1995
2
Supratentorial ependymoma in childhood: more than just RELA or YAP. 61
33481105 2021
3
A rare case of paediatric astroblastoma with concomitant MN1-GTSE1 and EWSR1-PATZ1 gene fusions altering management. 61
33534137 2021
4
Central nervous system neuroepithelial tumors with MN1-alteration: an individual patient data meta-analysis of 73 cases. 61
32601775 2020
5
Well-differentiated Astroblastoma with Both Focal Anaplastic Features and a Meningioma 1 Gene Alteration. 61
33062570 2020
6
Malignant Astroblastoma 61
32212579 2020
7
Cerebral hemispheric glioblastoma with PNET-like morphology and histone H3.3 G34 mutation in younger patients: Report of three rare cases and diagnostic pitfalls. 61
32317528 2020
8
Temporal lobe angiocentric glioma with oligodendroglioma-like areas: a rare association of an uncommon tumor. A case report with review of literature. 61
31897632 2020
9
Spinal cord astroblastoma with an EWSR1-BEND2 fusion classified as a high-grade neuroepithelial tumour with MN1 alteration. 61
31863478 2020
10
[Recurrent High-grade Astroblastoma Treated with Stereotactic Radiotherapy:A Case Report]. 61
32094314 2020
11
Early versus delayed postoperative radiotherapy for treatment of low-grade gliomas. 61
31958162 2020
12
Molecular Profiling Reclassifies Adult Astroblastoma into Known and Clinically Distinct Tumor Entities with Frequent Mitogen-Activated Protein Kinase Pathway Alterations. 61
31346129 2019
13
Extra-axial anaplastic astroblastoma in a 67-year-old woman. 61
31206872 2019
14
MN1 rearrangement in astroblastoma: study of eight cases and review of literature. 61
31111274 2019
15
Posterior fossa astroblastoma in a child: a case report and a review of the literature. 61
30859299 2019
16
A case report of high-grade astroblastoma in a young adult. 61
30813777 2019
17
Genomic analysis demonstrates that histologically-defined astroblastomas are molecularly heterogeneous and that tumors with MN1 rearrangement exhibit the most favorable prognosis. 61
30876455 2019
18
RBM10 truncation in astroblastoma in a patient with history of mandibular ameloblastoma: A case report. 61
30803556 2019
19
BRAF V600E-mutated central nervous system tumor with divergent morphological feature - Anaplastic pleomorphic xanthoastrocytoma-like and astroblastoma-like. 61
30557911 2019
20
Role of DNA Methylation Profile in Diagnosing Astroblastoma: A Case Report and Literature Review. 61
31114608 2019
21
Brainstem astroblastoma with MN1 translocation. 61
30238518 2018
22
[Astroblastoma: A rare glial tumor]. 61
30487065 2018
23
Co-occurrence of astrocytoma and astroblastoma: Case report and literature review. 61
29939429 2018
24
Astroblastoma: a distinct tumor entity characterized by alterations of the X chromosome and MN1 rearrangement. 61
28990708 2018
25
Primary spinal cord astroblastoma: case report. 61
29498581 2018
26
The use of 5-aminolevulinic acid to assist gross total resection of pediatric astroblastoma. 61
29305683 2018
27
Patterns of care and treatment outcomes of patients with astroblastoma: a National Cancer Database analysis. 61
29708401 2018
28
Astroblastoma - a rare and challenging tumor: a case report and review of the literature. 61
29678196 2018
29
Multimodal molecular analysis of astroblastoma enables reclassification of most cases into more specific molecular entities. 61
28960623 2018
30
The ten-year evolutionary trajectory of a highly recurrent paediatric high grade neuroepithelial tumour with MN1:BEND2 fusion. 61
29348602 2018
31
Astroblastoma - reviewing literature and one case report. 61
30845307 2018
32
Astroblastoma in a Young Female Patient: A Case Report and Literature Review of Clinicopathological, Radiological and Prognostic Characteristics and Current Treatment Strategies. 61
29188215 2017
33
Patterns of care and survival outcomes in patients with astroblastoma: an individual patient data analysis of 152 cases. 61
28477040 2017
34
Prevalence and clinicopathological features of H3.3 G34-mutant high-grade gliomas: a retrospective study of 411 consecutive glioma cases in a single institution. 61
28447171 2017
35
Development of cystic malacia after high-dose cranial irradiation of pediatric CNS tumors in long-term follow-up. 61
28378288 2017
36
Characterization of stem-like cells in a new astroblastoma cell line. 61
28232116 2017
37
Some characteristics of gliomas managed at a Neurosurgery centre in Nigeria. 61
28492209 2017
38
Morphological and molecular features of astroblastoma, including BRAFV600E mutations, suggest an ontological relationship to other cortical-based gliomas of children and young adults. 61
27416954 2017
39
A Pediatric Tumor Found Frequently in the Adult Population: A Case of Anaplastic Astroblastoma in an Elderly Patient and Review of the Literature. 61
28239500 2017
40
Erratum: A case of astroblastoma: Radiological and histopathological characteristics and a review of current treatment options. 61
29259838 2017
41
Neuroradiologic characteristics of astroblastoma and systematic review of the literature: 2 new cases and 125 cases reported in 59 publications. 61
27048363 2016
42
Genomic characterization of recurrent high-grade astroblastoma. 61
27425854 2016
43
Hemorrhage in astroblastoma: An unusual manifestation of an extremely rare entity. 61
26547295 2016
44
A Rare Malignant Fetal Brain Tumor. 61
26044034 2016
45
A case of astroblastoma: Radiological and histopathological characteristics and a review of current treatment options. 61
28144474 2016
46
Rare glial tumors. 61
26948368 2016
47
Adult intraventricular astroblastoma. 61
26831319 2016
48
Astroblastoma: Case Report and Review of Literature. 61
27349390 2016
49
A case of cerebral astroblastoma with rhabdoid features: a cytological, histological, and immunohistochemical study. 61
26614252 2016
50
Well-differentiated and anaplastic astroblastoma in the same patient: a case report and review of the literature. 61
26227256 2015

Variations for Astroblastoma

Expression for Astroblastoma

Search GEO for disease gene expression data for Astroblastoma.

Pathways for Astroblastoma

Pathways related to Astroblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.99 TUBB SYP GFAP ENO2
2
Show member pathways
11.29 VIM TUBB NES GFAP
3 10.82 VIM SYP NES GFAP

GO Terms for Astroblastoma

Cellular components related to Astroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 astrocyte projection GO:0097449 9.16 GJB2 GFAP
2 intermediate filament cytoskeleton GO:0045111 9.13 VIM NES GFAP
3 cell body GO:0044297 8.92 TUBB GJB2 GFAP BRAF

Biological processes related to Astroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament organization GO:0045109 9.26 VIM GFAP
2 astrocyte development GO:0014002 9.16 VIM GFAP
3 Bergmann glial cell differentiation GO:0060020 8.96 VIM GFAP
4 intermediate filament-based process GO:0045103 8.62 VIM GFAP

Molecular functions related to Astroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.03 VIM TUBB SYP NES MUC1 MN1
2 identical protein binding GO:0042802 9.17 VIM SYP IDH1 GJB2 GFAP EWSR1
3 structural constituent of cytoskeleton GO:0005200 9.13 VIM TUBB GFAP

Sources for Astroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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