Astroblastoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

GARD: ¹⁹ Astroblastoma is a rare glial tumor usually located in the cerebral hemisphere of the brain. It can occur in individuals of any age, but occurs predominantly in children and young adults. Signs and symptoms depend on the location and size of the tumor but most commonly include headaches and seizures. Because these tumors are rare, there is little known regarding their behavior and how they should be managed. Adjuvant therapy, including radiation and/or chemotherapy, is recommended for high-grade and recurrent cases (although its effectiveness is controversial).

MalaCards based summary: Astroblastoma, also known as cerebral astroblastoma, is related to astroblastoma, mn1-altered and cellular ependymoma. An important gene associated with Astroblastoma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Chromatin Regulation / Acetylation and Neural Stem Cells and Lineage-specific Markers. Affiliated tissues include brain, parietal lobe and temporal lobe, and related phenotypes are Increased shRNA abundance (Z-score > 2) and cellular

Orphanet: ⁵⁸ A very rare glial neoplasm of the central nervous system, most often with an intra-axial peripheral supratentorial location in one hemisphere of the frontal or parietal lobes and usually presenting in infants and young adults with symptoms of vomiting, loss of consciousness, epileptic seizures and headaches.

Disease Ontology: ¹¹ A malignant astrocytoma that is characterized by tumor cells with characteristics suggestive of an astrocytic origin (positive for GFAP), arranged perivascularly.

Wikipedia: ⁷⁵ Astroblastoma is a rare glial tumor derived from the astroblast, a type of cell that closely resembles... more...

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Related Diseases for Astroblastoma

Diseases related to Astroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)

#	Related Disease	Score	Top Affiliating Genes
1	astroblastoma, mn1-altered	31.1	ZFTA PATZ1 MN1 MAMLD1 EWSR1 CXXC5
2	cellular ependymoma	30.3	ZFTA VIM RELA GFAP
3	oligodendroglioma	30.1	VIM OLIG2 IDH1 GFAP
4	gemistocytic astrocytoma	29.8	IDH1 GFAP ATRX
5	idh-wildtype glioblastoma	29.8	OLIG2 IDH1 ATRX
6	anaplastic astrocytoma	29.6	OLIG2 KIAA1549 IDH1 GFAP ATRX
7	pleomorphic xanthoastrocytoma	29.5	ZFTA MYBL1 MN1 KIAA1549 IDH1 ATRX
8	gliosarcoma	29.4	VIM OLIG2 IDH1 GFAP ATRX
9	anaplastic pleomorphic xanthoastrocytoma	29.4	OLIG2 MN1 KIAA1549 IDH1 BEND2 ATRX
10	neurofibromatosis, type i	29.4	KIAA1549 IDH1 EWSR1
11	pilocytic astrocytoma	29.4	OLIG2 MYBL1 KIAA1549 IDH1 GFAP ATRX
12	gliomatosis cerebri	29.4	OLIG2 KIAA1549 IDH1 GFAP ATRX
13	diffuse astrocytoma	29.3	OLIG2 MYBL1 KIAA1549 IDH1 GFAP ATRX
14	meningioma, familial	29.1	VIM OLIG2 MN1 KIAA1549 IDH1 GFAP
15	glial tumor	10.5
16	rare tumor	10.5
17	glioma susceptibility 1	10.4
18	brain cancer	10.4
19	third ventricle chordoid glioma	10.3	OLIG2 GFAP
20	childhood infratentorial ependymoma	10.3	ZFTA MN1
21	histoplasmosis meningitis	10.3	IDH1 GFAP
22	rhabdoid meningioma	10.3	VIM GFAP
23	chondroid lipoma	10.3	ZFTA MN1
24	gliofibroma	10.2	KIAA1549 GFAP
25	central nervous system cancer	10.2
26	cerebrovascular benign neoplasm	10.2	IDH1 GFAP
27	simple partial epilepsy	10.2	KIAA1549 IDH1
28	optic nerve neoplasm	10.2	OLIG2 KIAA1549
29	pilocytic astrocytoma of cerebellum	10.2	KIAA1549 IDH1
30	glioblastoma	10.2
31	juvenile pilocytic astrocytoma	10.2	KIAA1549 IDH1
32	syringoma	10.2	VIM GFAP
33	papillary craniopharyngioma	10.2	KIAA1549 IDH1
34	obstructive hydrocephalus	10.1	OLIG2 KIAA1549 GFAP
35	thalamic neoplasm	10.1	MYBL1 KIAA1549
36	embryonal tumor with multilayered rosettes, c19mc-altered	10.1	MN1 GFAP FOXR2
37	gangliocytoma	10.1	KIAA1549 IDH1 GFAP
38	fibrillary astrocytoma	10.1	KIAA1549 IDH1 GFAP
39	brain stem astrocytic neoplasm	10.1	IDH1 ATRX
40	cerebellar astrocytoma	10.1	KIAA1549 IDH1 BEND2
41	medulloepithelioma	10.1	OLIG2 GFAP FOXR2
42	idh-mutant anaplastic astrocytoma	10.1	IDH1 ATRX
43	pineoblastoma	10.1	OLIG2 GFAP FOXR2
44	idh-wildtype anaplastic astrocytoma	10.1	IDH1 ATRX
45	optic nerve glioma	10.1	OLIG2 KIAA1549 IDH1
46	childhood astrocytic tumor	10.1	KIAA1549 IDH1
47	astrocytoma, idh-mutant, grade 4	10.1	IDH1 ATRX
48	supratentorial primitive neuroectodermal tumor	10.1	IDH1 GFAP FOXR2
49	mixed oligodendroglioma-astrocytoma	10.1	IDH1 ATRX
50	cone-rod dystrophy 2	10.1

Graphical network of the top 20 diseases related to Astroblastoma:

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Symptoms & Phenotypes for Astroblastoma

GenomeRNAi Phenotypes related to Astroblastoma according to GeneCards Suite gene sharing:

²⁵ (show all 21)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-105	9.68	BCORL1 EWSR1
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-11	9.68	BCORL1
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	9.68	BCORL1
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-128	9.68	MYBL1
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-135	9.68	BCORL1
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-152	9.68	EWSR1
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-156	9.68	BCORL1
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-161	9.68	ATRX
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-164	9.68	EWSR1
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-19	9.68	EWSR1
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-203	9.68	EWSR1
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-207	9.68	BCORL1
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-212	9.68	BCORL1
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-216	9.68	BCORL1
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	9.68	EWSR1
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-53	9.68	BCORL1
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-58	9.68	BCORL1
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	9.68	ATRX
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-71	9.68	ATRX
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-89	9.68	EWSR1 MYBL1
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-99	9.68	EWSR1

MGI Mouse Phenotypes related to Astroblastoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	9.36	ATRX BCORL1 BEND2 CXXC5 EWSR1 GFAP

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Drugs & Therapeutics for Astroblastoma

Search Clinical Trials, NIH Clinical Center for Astroblastoma

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Genetic Tests for Astroblastoma

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Anatomical Context for Astroblastoma

Organs/tissues related to Astroblastoma:

MalaCards : Brain, Parietal Lobe, Temporal Lobe, Hypothalamus, Cerebellum, Eye, Spinal Cord

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Publications for Astroblastoma

Articles related to Astroblastoma:

(show top 50) (show all 189)

#	Title	Authors	PMID	Year
1	Semiquantitative postembedding characterization of intermediate filaments in central nervous system lesions using immunoelectron microscopy. ⁵³ ⁶²	Geiger DH...Rutherfoord GS	9044656	1995
2	Recurrent high-grade astroblastoma with MN1-BEND2 fusion in spinal cord and literature review. ⁶²	Sun D...Guan H	36366964	2022
3	Intraoperative high-field resonance: How to optimize its use in our healthcare system. ⁶²	Limpo H...Tejada S	34625382	2022
4	Upfront molecular targeted therapy for the treatment of BRAF-mutant pediatric high-grade glioma. ⁶²	Rosenberg T...Karajannis MA	35397478	2022
5	Upregulation of miRNA-26a enhances the apoptosis of cerebral neurons by targeting EphA2 and inhibiting the MAPK pathway. ⁶²	Chi B...Pang L	36049464	2022
6	Spinal astroblastoma: a rare tumour in an unusual location. ⁶²	Rao S...Santosh V	35152342	2022
7	Paediatric astroblastoma-like neuroepithelial tumour of the spinal cord with a MAMLD1-BEND2 rearrangement. ⁶²	Rossi S...Alaggio R	35301744	2022
8	Soft-tissue sarcoma with MN1-BEND2 fusion: A case report and comparison with astroblastoma. ⁶²	Yoshida A...Mori T	35094441	2022
9	Circumscribed astrocytic gliomas: Contribution of molecular analyses to histopathology diagnosis in the WHO CNS5 classification. ⁶²	Koy Y...Tihan T	35562132	2022
10	Prevalence of BRAFV600 in glioma and use of BRAF Inhibitors in patients with BRAFV600 mutation-positive glioma: systematic review. ⁶²	Andrews LJ...Kurian KM	34718782	2022
11	Cerebral astroblastoma radiologically mimicking pilocytic astrocytoma: A case report. ⁶²	Joshi PR...Sedain G	35498346	2022
12	[Astroblastoma with Rapid Cyst Expansion and Hemorrhage in an Adult: A Case Report]. ⁶²	Oku S...Sugiyama K	35437291	2022
13	Neuroimaging of astroblastomas: A case series and systematic review. ⁶²	Kurokawa R...Moritani T	34816541	2022
14	High-grade glioma with pleomorphic and pseudopapillary features (HPAP): a proposed type of circumscribed glioma in adults harboring frequent TP53 mutations and recurrent monosomy 13. ⁶²	Pratt D...Aldape K	35103816	2022
15	A novel LARGE1-AFF2 fusion expanding the molecular alterations associated with the methylation class of neuroepithelial tumors with PATZ1 fusions. ⁶²	Tauziede-Espariat A...the RENOCLIP-LOC	35115049	2022
16	Clinicoradiological and histopathological characteristics and treatment outcomes of cerebral astroblastoma in children: a single-institution experience. ⁶²	Jeon C...Choi JW	35180693	2022
17	Thirteen-year long-term follow-up in a rare case of anaplastic astroblastoma: What makes the difference? ⁶²	Allison CM...Sinclair G	35673675	2022
18	The Diagnostic Value of Pan-Trk Expression to Detect Neurotrophic Tyrosine Receptor Kinase (NTRK) Gene Fusion in CNS Tumours: A Study Using Next-Generation Sequencing Platform. ⁶²	Mohamed F...Fdl-Elmula I	35295612	2022
19	Recurrent HGNET-MN1 altered (astroblastoma MN1-altered) of the foramen magnum: Case report and molecular classification. ⁶²	Gopakumar S...Rao G	35509530	2022
20	EWSR1-BEND2 fusion defines an epigenetically distinct subtype of astroblastoma. ⁶²	Lucas CG...Solomon DA	34825267	2022
21	A pediatric cerebral tumor with MN1 alteration and pathological features mimicking carcinoma metastasis: may the terminology "high grade neuroepithelial tumor with MN1 alteration" still be relevant? ⁶²	Sari R...Elmaci I	34269865	2021
22	Molecular profiling of pediatric and adolescent ependymomas: identification of genetic variants using a next-generation sequencing panel. ⁶²	Cabral de Carvalho Correa D...Caminada de Toledo SR	34570300	2021
23	Spinal cord astroblastoma with EWSR1-BEND2 fusion classified as HGNET-MN1 by methylation classification: a case report. ⁶²	Tsutsui T...Miyamoto S	34313881	2021
24	A rare case of paediatric astroblastoma with concomitant MN1-GTSE1 and EWSR1-PATZ1 gene fusions altering management. ⁶²	Chadda KR...Genomics England Research Consortium	33534137	2021
25	Cerebral astroblastoma with oligodendroglial-like cells: A case report. ⁶²	Gu J...Yu J	34713831	2021
26	Supratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 fusions. ⁶²	Tauziede-Espariat A...RENOCLIP-LOC, the BIOMECA (Biomarkers for Ependymomas in Children, Adolescents) consortium	34389065	2021
27	High-Grade Intraventricular Astroblastoma in a Young Adult: A Rare and Controversial Tumor to Manage. ⁶²	Singh K...Sandhu P	34660370	2021
28	Cerebral Astroblastoma: A Rare Tumor. ⁶²	Dey B...Khonglah Y	34395111	2021
29	Unique pathological findings of astroblastoma with MN1 alteration in a patient with late recurrence. ⁶²	Ujihara M...Nishikawa R	33913040	2021
30	Supratentorial ependymoma in childhood: more than just RELA or YAP. ⁶²	Zschernack V...Pietsch T	33481105	2021
31	A Rare Case of a High-Grade Astroblastoma with 5-Year Follow-up. ⁶²	D Cruze L...Ganesh K	34211891	2021
32	Central nervous system neuroepithelial tumors with MN1-alteration: an individual patient data meta-analysis of 73 cases. ⁶²	Chen W...Tan CL	32601775	2020
33	Well-differentiated Astroblastoma with Both Focal Anaplastic Features and a Meningioma 1 Gene Alteration. ⁶²	Fudaba H...Fujiki M	33062570	2020
34	Malignant Astroblastoma ⁶²	Sarper B...Yeni Bayraktar H	32212579	2020
35	Cerebral hemispheric glioblastoma with PNET-like morphology and histone H3.3 G34 mutation in younger patients: Report of three rare cases and diagnostic pitfalls. ⁶²	Cheng Y...Wu Q	32317528	2020
36	Temporal lobe angiocentric glioma with oligodendroglioma-like areas: a rare association of an uncommon tumor. A case report with review of literature. ⁶²	Gupta S...Kumar R	31897632	2020
37	Spinal cord astroblastoma with an EWSR1-BEND2 fusion classified as a high-grade neuroepithelial tumour with MN1 alteration. ⁶²	Yamasaki K...Hara J	31863478	2020
38	[Recurrent High-grade Astroblastoma Treated with Stereotactic Radiotherapy:A Case Report]. ⁶²	Higuchi S...Ueba T	32094314	2020
39	Early versus delayed postoperative radiotherapy for treatment of low-grade gliomas. ⁶²	Dhawan S...Venteicher AS	31958162	2020
40	Molecular Profiling Reclassifies Adult Astroblastoma into Known and Clinically Distinct Tumor Entities with Frequent Mitogen-Activated Protein Kinase Pathway Alterations. ⁶²	Boisseau W...Idbaih A	31346129	2019
41	Extra-axial anaplastic astroblastoma in a 67-year-old woman. ⁶²	Bernasconi R...Barresi V	31206872	2019
42	Posterior fossa astroblastoma in a child: a case report and a review of the literature. ⁶²	Yapicier O...Kilic T	30859299	2019
43	MN1 rearrangement in astroblastoma: study of eight cases and review of literature. ⁶²	Mhatre R...Santosh V	31111274	2019
44	A case report of high-grade astroblastoma in a young adult. ⁶²	Bhalerao S...Adhav A	30813777	2019
45	Genomic analysis demonstrates that histologically-defined astroblastomas are molecularly heterogeneous and that tumors with MN1 rearrangement exhibit the most favorable prognosis. ⁶²	Lehman NL...Orr BA	30876455	2019
46	RBM10 truncation in astroblastoma in a patient with history of mandibular ameloblastoma: A case report. ⁶²	Majd NK...Penas-Prado M	30803556	2019
47	BRAF V600E-mutated central nervous system tumor with divergent morphological feature - Anaplastic pleomorphic xanthoastrocytoma-like and astroblastoma-like. ⁶²	Purkait S...Malgulwar PB	30557911	2019
48	Role of DNA Methylation Profile in Diagnosing Astroblastoma: A Case Report and Literature Review. ⁶²	Petruzzellis G...Miele E	31114608	2019
49	Brainstem astroblastoma with MN1 translocation. ⁶²	Shin SA...Park SH	30238518	2018
50	[Astroblastoma: A rare glial tumor]. ⁶²	Regragui M...El Azhari A	30487065	2018

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Genes for Astroblastoma

Genes related to Astroblastoma (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	GFAP	Glial Fibrillary Acidic Protein	Protein Coding	22	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	2187587 9044656
2	MN1	MN1 Proto-Oncogene, Transcriptional Regulator	Protein Coding	8.39	DISEASES inferred ¹⁴
3	BEND2	BEN Domain Containing 2	Protein Coding	8.27	DISEASES inferred ¹⁴
4	VIM	Vimentin	Protein Coding	8.04	Novoseek inferred ⁵³	9044656
5	OLIG2	Oligodendrocyte Transcription Factor 2	Protein Coding	6.66	DISEASES inferred ¹⁴
6	ZFTA	Zinc Finger Translocation Associated	Protein Coding	6.62	DISEASES inferred ¹⁴
7	CXXC5	CXXC Finger Protein 5	Protein Coding	6.23	DISEASES inferred ¹⁴
8	IDH1	Isocitrate Dehydrogenase (NADP(+)) 1	Protein Coding	6.12	DISEASES inferred ¹⁴
9	MAMLD1	Mastermind Like Domain Containing 1	Protein Coding	6.07	DISEASES inferred ¹⁴
10	KIAA1549	KIAA1549	Protein Coding	6.07	DISEASES inferred ¹⁴
11	PATZ1	POZ/BTB And AT Hook Containing Zinc Finger 1	Protein Coding	6.01	DISEASES inferred ¹⁴
12	FOXR2	Forkhead Box R2	Protein Coding	5.88	DISEASES inferred ¹⁴
13	MYBL1	MYB Proto-Oncogene Like 1	Protein Coding	5.71	DISEASES inferred ¹⁴
14	ATRX	ATRX Chromatin Remodeler	Protein Coding	5.66	DISEASES inferred ¹⁴
15	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	5.61	DISEASES inferred ¹⁴
16	EWSR1	EWS RNA Binding Protein 1	Protein Coding	5.44	DISEASES inferred ¹⁴
17	BCORL1	BCL6 Corepressor Like 1	Protein Coding	5.4	DISEASES inferred ¹⁴

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Variations for Astroblastoma

Cosmic variations for Astroblastoma:

⁸ (show all 27)

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM102656129	NF2	central nervous system,brain,other,neoplasm	c.575A>G	p.Y192C	22:29655652-29655652	4
2	COSM89046819	NF2	central nervous system,brain,other,neoplasm	c.575A>G	p.Y192C	22:29655652-29655652	4
3	COSM105514140	NF2	central nervous system,brain,other,neoplasm	c.575A>G	p.Y192C	22:29655652-29655652	4
4	COSM94463526	NF2	central nervous system,brain,other,neoplasm	c.452A>G	p.Y151C	22:29655652-29655652	4
5	COSM102848205	NF2	central nervous system,brain,other,neoplasm	c.575A>G	p.Y192C	22:29655652-29655652	4
6	COSM93474794	NF2	central nervous system,brain,other,neoplasm	c.575A>G	p.Y192C	22:29655652-29655652	4
7	COSM89067962	NF2	central nervous system,brain,other,neoplasm	c.326A>G	p.Y109C	22:29655652-29655652	4
8	COSM105111282	NF2	central nervous system,brain,other,neoplasm	c.447+13367A>G	p.?	22:29655652-29655652	4
9	COSM95502154	NF2	central nervous system,brain,other,neoplasm	c.449A>G	p.Y150C	22:29655652-29655652	4
10	COSM92446479	NF2	central nervous system,brain,other,neoplasm	c.326A>G	p.Y109C	22:29655652-29655652	4
11	COSM90465359	IDH1	central nervous system,brain,other,neoplasm	c.395G>A	p.R132H	2:208248388-208248388	4
12	COSM112752230	IDH1	central nervous system,brain,other,neoplasm	c.395G>A	p.R132H	2:208248388-208248388	4
13	COSM103033757	IDH1	central nervous system,brain,other,neoplasm	c.395G>A	p.R132H	2:208248388-208248388	4
14	COSM103033796	IDH1	central nervous system,brain,other,neoplasm	c.394C>T	p.R132C	2:208248389-208248389	4
15	COSM103034325	IDH1	central nervous system,brain,other,neoplasm	c.394C>A	p.R132S	2:208248389-208248389	4
16	COSM112752272	IDH1	central nervous system,brain,other,neoplasm	c.394C>T	p.R132C	2:208248389-208248389	4
17	COSM90465396	IDH1	central nervous system,brain,other,neoplasm	c.394C>T	p.R132C	2:208248389-208248389	4
18	COSM90466087	IDH1	central nervous system,brain,other,neoplasm	c.394C>A	p.R132S	2:208248389-208248389	4
19	COSM90465733	IDH1	central nervous system,brain,other,neoplasm	c.394C>G	p.R132G	2:208248389-208248389	4
20	COSM112752610	IDH1	central nervous system,brain,other,neoplasm	c.394C>G	p.R132G	2:208248389-208248389	4
21	COSM112752921	IDH1	central nervous system,brain,other,neoplasm	c.394C>A	p.R132S	2:208248389-208248389	4
22	COSM112752563	IDH1	central nervous system,brain,other,neoplasm	c.395G>T	p.R132L	2:208248388-208248388	4
23	COSM90465675	IDH1	central nervous system,brain,other,neoplasm	c.395G>T	p.R132L	2:208248388-208248388	4
24	COSM103034038	IDH1	central nervous system,brain,other,neoplasm	c.394C>G	p.R132G	2:208248389-208248389	4
25	COSM103034000	IDH1	central nervous system,brain,other,neoplasm	c.395G>T	p.R132L	2:208248388-208248388	4
26	COSM93220513	FOXO3	central nervous system,brain,other,neoplasm	c.583A>T	p.K195*	6:108561791-108561791	4
27	COSM102860866	FOXO3	central nervous system,brain,other,neoplasm	c.583A>T	p.K195*	6:108561791-108561791	4

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Expression for Astroblastoma

Search GEO for disease gene expression data for Astroblastoma.

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Pathways for Astroblastoma

Pathways related to Astroblastoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Chromatin Regulation / Acetylation ³	11.66	RELA EWSR1 CXXC5 ATRX
2	Neural Stem Cells and Lineage-specific Markers ⁶⁵	11.23	VIM OLIG2 GFAP
3	Pathways affected in adenoid cystic carcinoma ⁷⁴	10.59	MYBL1 BCORL1 ATRX

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GO Terms for Astroblastoma

Biological processes related to Astroblastoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of DNA-templated transcription	GO:0006355	9.8	RELA PATZ1 OLIG2 MYBL1 MN1 FOXR2
2	Bergmann glial cell differentiation	GO:0060020	9.46	VIM GFAP
3	intermediate filament-based process	GO:0045103	8.62	VIM GFAP

Sources

Sources for Astroblastoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: AST002 MIFTS: 38	Astroblastoma Categories: Cancer diseases, Neuronal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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