MCID: AST002
MIFTS: 35

Astroblastoma

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Astroblastoma

MalaCards integrated aliases for Astroblastoma:

Name: Astroblastoma 12 53 59 55 15 73
Cerebral Astroblastoma 53

Characteristics:

Orphanet epidemiological data:

59
astroblastoma
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adolescent,Adult,Childhood,Infancy;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:7305
MeSH 44 D018302
NCIt 50 C4324
SNOMED-CT 68 48952003
Orphanet 59 ORPHA251679
UMLS via Orphanet 74 C0334587
ICD10 via Orphanet 34 C71.9
UMLS 73 C0334587

Summaries for Astroblastoma

NIH Rare Diseases : 53 Astroblastoma is a rare glial tumor usually located in the cerebral hemisphere of the brain. It can occur in individuals of any age, but occurs predominantly in children and young adults. Signs and symptoms depend on the location and size of the tumor but most commonly include headaches and seizures. Because these tumors are rare, there is little known regarding their behavior and how they should be managed. Gross total resection (complete removal) of the tumor is recommended and is associated with a good prognosis for low-grade tumors. Adjuvant therapy, including radiation and/or chemotherapy, is recommended for high-grade and recurrent cases (although its effectiveness is controversial).

MalaCards based summary : Astroblastoma, also known as cerebral astroblastoma, is related to pleomorphic xanthoastrocytoma and oligodendroglioma. An important gene associated with Astroblastoma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Neuroscience and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include brain, cerebellum and hypothalamus.

Wikipedia : 76 Astroblastoma is a rare glial tumor derived from the astroblast, a type of cell that closely resembles... more...

Related Diseases for Astroblastoma

Diseases related to Astroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 193)
# Related Disease Score Top Affiliating Genes
1 pleomorphic xanthoastrocytoma 30.0 GFAP SYP
2 oligodendroglioma 29.8 ENO2 GFAP SYP
3 ependymoma 29.3 ENO2 GFAP NES SYP VIM
4 status epilepticus 10.2 ENO2 GFAP
5 scrapie 10.2 ENO2 GFAP
6 neuroma 10.2 ENO2 GFAP
7 intracranial cysts 10.2 ENO2 GFAP
8 melanotic medulloblastoma 10.2 ENO2 GFAP
9 cerebellar medulloblastoma 10.2 ENO2 GFAP
10 plexiform schwannoma 10.1 ENO2 GFAP
11 meningioma, radiation-induced 10.1 GFAP VIM
12 myoepithelioma 10.1 GFAP VIM
13 pleomorphic adenoma 10.1 GFAP VIM
14 bednar tumor 10.1 ENO2 VIM
15 leiomyosarcoma 10.1 ENO2 VIM
16 epulis 10.1 ENO2 VIM
17 ossifying fibromyxoid tumor 10.1 ENO2 VIM
18 epithelioid leiomyosarcoma 10.1 ENO2 VIM
19 anaplastic ganglioglioma 10.1 GFAP NES
20 paraganglioma 10.1 ENO2 SYP
21 peripheral nervous system neoplasm 10.1 ENO2 SYP
22 sweat gland cancer 10.1 ENO2 SYP
23 lung benign neoplasm 10.1 ENO2 SYP
24 adrenal carcinoma 10.1 ENO2 SYP
25 merkel cell carcinoma 10.1 ENO2 SYP
26 large cell carcinoma 10.1 ENO2 SYP
27 cutaneous leiomyosarcoma 10.1 GFAP VIM
28 dermatofibrosarcoma protuberans 10.1 NES VIM
29 parachordoma 10.1 GFAP VIM
30 chordoma 10.1 GFAP VIM
31 central nervous system germ cell tumor 10.1 GFAP NES
32 sarcoma 10.1
33 arteriovenous malformation 10.1
34 astrocytoma 10.1
35 rhabdoid meningioma 10.1 GFAP VIM
36 syringocystadenoma papilliferum 10.1 GFAP VIM
37 traumatic brain injury 10.1 ENO2 GFAP
38 carotid body cancer 10.1 ENO2 SYP
39 clear cell meningioma 10.1 GFAP VIM
40 brain injury 10.1 ENO2 GFAP
41 atypical teratoid rhabdoid tumor 10.1 GFAP SYP
42 malignant sertoli cell tumor 10.1 ENO2 SYP
43 giant cell glioblastoma 10.1 GFAP SYP
44 urinary bladder small cell neuroendocrine carcinoma 10.1 ENO2 SYP
45 myxopapillary ependymoma 10.1 GFAP VIM
46 small cell carcinoma 10.1 ENO2 SYP
47 auditory system cancer 10.1 ENO2 SYP
48 syringoma 10.1 GFAP VIM
49 sinonasal undifferentiated carcinoma 10.1 ENO2 SYP
50 gallbladder small cell carcinoma 10.1 ENO2 SYP

Graphical network of the top 20 diseases related to Astroblastoma:



Diseases related to Astroblastoma

Symptoms & Phenotypes for Astroblastoma

Drugs & Therapeutics for Astroblastoma

Search Clinical Trials , NIH Clinical Center for Astroblastoma

Genetic Tests for Astroblastoma

Anatomical Context for Astroblastoma

MalaCards organs/tissues related to Astroblastoma:

41
Brain, Cerebellum, Hypothalamus, Temporal Lobe, Parietal Lobe, Lung, Pineal

Publications for Astroblastoma

Articles related to Astroblastoma:

(show top 50) (show all 95)
# Title Authors Year
1
Astroblastoma - a rare and challenging tumor: a case report and review of the literature. ( 29678196 )
2018
2
Co-occurrence of astrocytoma and astroblastoma: Case report and literature review. ( 29939429 )
2018
3
Patterns of care and treatment outcomes of patients with astroblastoma: a National Cancer Database analysis. ( 29708401 )
2018
4
The use of 5-aminolevulinic acid to assist gross total resection of pediatric astroblastoma. ( 29305683 )
2018
5
Primary spinal cord astroblastoma: case report. ( 29498581 )
2018
6
BRAF V600E-mutated central nervous system tumor with divergent morphological feature - Anaplastic pleomorphic xanthoastrocytoma-like and astroblastoma-like. ( 30557911 )
2018
7
Brainstem astroblastoma with MN1 translocation. ( 30238518 )
2018
8
Astroblastoma: a distinct tumor entity characterized by alterations of the X chromosome and MN1 rearrangement. ( 28990708 )
2017
9
Multimodal molecular analysis of astroblastoma enables reclassification of most cases into more specific molecular entities. ( 28960623 )
2017
10
Erratum: A case of astroblastoma: Radiological and histopathological characteristics and a review of current treatment options. ( 29259838 )
2017
11
Characterization of stem-like cells in a new astroblastoma cell line. ( 28232116 )
2017
12
A Pediatric Tumor Found Frequently in the Adult Population: A Case of Anaplastic Astroblastoma in an Elderly Patient and Review of the Literature. ( 28239500 )
2017
13
Astroblastoma in a Young Female Patient: A Case Report and Literature Review of Clinicopathological, Radiological and Prognostic Characteristics and Current Treatment Strategies. ( 29188215 )
2017
14
Patterns of care and survival outcomes in patients with astroblastoma: an individual patient data analysis of 152 cases. ( 28477040 )
2017
15
A case of astroblastoma: Radiological and histopathological characteristics and a review of current treatment options. ( 28144474 )
2016
16
Genomic characterization of recurrent high-grade astroblastoma. ( 27425854 )
2016
17
Hemorrhage in astroblastoma: An unusual manifestation of an extremely rare entity. ( 26547295 )
2016
18
Neuroradiologic characteristics of astroblastoma and systematic review of the literature: 2 new cases and 125 cases reported in 59 publications. ( 27048363 )
2016
19
A case of cerebral astroblastoma with rhabdoid features: a cytological, histological, and immunohistochemical study. ( 26614252 )
2016
20
Adult intraventricular astroblastoma. ( 26831319 )
2016
21
Morphological and molecular features of astroblastoma, including BRAFV600E mutations, suggest an ontological relationship to other cortical-based gliomas of children and young adults. ( 27416954 )
2016
22
Astroblastoma: Case Report and Review of Literature. ( 27349390 )
2016
23
Distant dissemination of mixed low-grade astroblastoma-arteriovenous malformation after initial operation: a case report. ( 26261652 )
2015
24
Intraventricular Astroblastoma in an Infant: A Case Report and Review of the Literature. ( 26406441 )
2015
25
Astroblastoma of cerebrum: A rare case report and review of literature. ( 26458709 )
2015
26
Astroblastoma: beside being a tumor entity, an occasional phenotype of astrocytic gliomas? ( 25737639 )
2015
27
Well-differentiated and anaplastic astroblastoma in the same patient: a case report and review of the literature. ( 26227256 )
2015
28
Astroblastoma: report of two cases with unexpected clinical behavior and review of the literature. ( 25108699 )
2014
29
High-grade astroblastoma in a child: Report of one case and review of literature. ( 25101206 )
2014
30
Cerebral astroblastoma: A radiopathological diagnosis. ( 24891904 )
2014
31
Astroblastoma: rare incidence and challenges in the pattern of care. ( 24607547 )
2014
32
Mixed astroblastoma-arteriovenous malformation complex: a case report. ( 24005749 )
2013
33
Recurrent low-grade astroblastoma with signet ring-like cells and high proliferative index. ( 23301912 )
2013
34
Cerebral astroblastoma in an adult: an immunohistochemical, ultrastructural and genetic study. ( 22994361 )
2013
35
Cerebral astroblastoma: A case report and review of literature. ( 22870162 )
2012
36
Pediatric astroblastoma: a rare case with a review of the literature. ( 23038221 )
2012
37
A newborn with massive congenital astroblastoma. ( 21491993 )
2011
38
Astroblastoma - a case report of a rare neuroepithelial tumor with complete remission after chemotherapy. ( 22011735 )
2011
39
Clinical features and post-surgical outcome of patients with astroblastoma. ( 21507653 )
2011
40
Recurrent astroblastoma treated with gamma knife radiosurgery. ( 20938716 )
2011
41
Astroblastoma with bone invasion. ( 22347336 )
2011
42
Anaplastic astroblastoma: a rare glial tumour. ( 22679316 )
2011
43
Anaplastic astroblastoma presenting as massive, sudden-onset, intraparenchymal hemorrhage. ( 21540623 )
2010
44
Anaplastic astroblastoma-sarcoma in neurofibromatosis Type 1. ( 20860891 )
2010
45
Two cases of pediatric high-grade astroblastoma with different clinical behavior. ( 20437876 )
2010
46
Anaplastic astroblastoma of childhood: aggressive behavior. ( 19357852 )
2009
47
Cerebral astroblastoma: analysis of six cases and critical review of treatment options. ( 19214707 )
2009
48
Unusual manifestations of astroblastoma: a radiologic-pathologic analysis. ( 18958463 )
2009
49
Supratentorial high grade astroblastoma: report of two cases and review of the literature. ( 19431125 )
2009
50
Intraventricular astroblastoma. Case report. ( 18352788 )
2008

Variations for Astroblastoma

Expression for Astroblastoma

Search GEO for disease gene expression data for Astroblastoma.

Pathways for Astroblastoma

Pathways related to Astroblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.87 ENO2 GFAP SYP
2
Show member pathways
11.17 GFAP NES VIM
3 10.82 GFAP NES SYP VIM

GO Terms for Astroblastoma

Cellular components related to Astroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell body GO:0044297 9.26 GFAP GJB2
2 intermediate filament cytoskeleton GO:0045111 9.16 GFAP NES
3 intermediate filament GO:0005882 9.13 GFAP NES VIM
4 astrocyte projection GO:0097449 8.62 GFAP GJB2

Biological processes related to Astroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron projection development GO:0010977 9.32 GFAP VIM
2 intermediate filament organization GO:0045109 9.26 GFAP VIM
3 astrocyte development GO:0014002 9.16 GFAP VIM
4 Bergmann glial cell differentiation GO:0060020 8.96 GFAP VIM
5 intermediate filament-based process GO:0045103 8.62 GFAP VIM

Molecular functions related to Astroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.26 GFAP GJB2 SYP VIM
2 structural molecule activity GO:0005198 8.8 GFAP NES VIM

Sources for Astroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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