MCID: ASY004
MIFTS: 18

Asymmetric Motor Neuropathy

Categories: Neuronal diseases

Aliases & Classifications for Asymmetric Motor Neuropathy

MalaCards integrated aliases for Asymmetric Motor Neuropathy:

Name: Asymmetric Motor Neuropathy 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:7559
NCIt 50 C27953
UMLS 70 C1332341

Summaries for Asymmetric Motor Neuropathy

MalaCards based summary : Asymmetric Motor Neuropathy is related to mononeuritis of upper limb and mononeuritis multiplex and charcot-marie-tooth disease type x. An important gene associated with Asymmetric Motor Neuropathy is PMP22 (Peripheral Myelin Protein 22), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. Related phenotype is homeostasis/metabolism.

Related Diseases for Asymmetric Motor Neuropathy

Diseases related to Asymmetric Motor Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 mononeuritis of upper limb and mononeuritis multiplex 10.2 PMP22 MAG
2 charcot-marie-tooth disease type x 10.1 PMP22 MFN2
3 charcot-marie-tooth disease, x-linked dominant, 1 10.1 PMP22 MFN2
4 charcot-marie-tooth disease, axonal, type 2d 10.0 PMP22 MFN2
5 charcot-marie-tooth disease, demyelinating, type 1b 10.0 PMP22 MFN2
6 median neuropathy 10.0 TTR PMP22
7 charcot-marie-tooth disease, demyelinating, type 1c 10.0 PMP22 MFN2
8 plasma protein metabolism disease 10.0 MAG B2M
9 autonomic peripheral neuropathy 10.0 TTR GSN
10 monoclonal gammopathy of uncertain significance 10.0 MAG B2M
11 blepharochalasis 10.0 TTR GSN
12 pediatric multiple sclerosis 10.0 TTR GSN
13 waldenstroem's macroglobulinemia 10.0 MAG B2M
14 al amyloidosis 9.9 TTR B2M
15 amyloid tumor 9.9 TTR B2M
16 blood protein disease 9.9 MAG B2M
17 hereditary neuropathies 9.9 PMP22 MFN2 MAG
18 amyloidosis, finnish type 9.9 TTR GSN
19 neuropathy, hereditary, with liability to pressure palsies 9.9 PMP22 MFN2 MAG
20 charcot-marie-tooth disease, demyelinating, type 1a 9.9 PMP22 MFN2 MAG
21 hypertrophic neuropathy of dejerine-sottas 9.9 PMP22 MFN2 MAG
22 sensory peripheral neuropathy 9.9 PMP22 MFN2 MAG
23 charcot-marie-tooth disease and deafness 9.9 PMP22 MFN2 MAG
24 ichthyosis, congenital, autosomal recessive 4a 9.9 H3-2 APOA1
25 mononeuropathy 9.9 TTR PMP22 MAG
26 demyelinating polyneuropathy 9.8 TTR PMP22 MAG
27 pelizaeus-merzbacher disease 9.8 PMP22 MAG
28 neuromuscular disease 9.8 PMP22 MFN2 MAG
29 nerve compression syndrome 9.8 TTR PMP22 B2M
30 tooth disease 9.8 TTR PMP22 MFN2
31 carpal tunnel syndrome 9.8 TTR PMP22 B2M
32 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 9.7 TTR PMP22 MFN2
33 cerebral amyloid angiopathy, cst3-related 9.7 TTR GSN
34 motor peripheral neuropathy 9.6 TTR PMP22 MFN2 MAG
35 charcot-marie-tooth disease 9.6 TTR PMP22 MFN2 MAG
36 amyloid neuropathy 9.6 TTR GSN APOA1
37 amyloidosis aa 9.5 TTR B2M APOA1
38 nephrotic syndrome 9.4 GSN B2M APOA1
39 chronic kidney disease 9.3 TTR B2M APOA1
40 hereditary amyloidosis 9.3 TTR GSN B2M APOA1
41 amyloidosis 9.3 TTR GSN B2M APOA1
42 amyloidosis, hereditary, transthyretin-related 9.3 TTR GSN B2M APOA1
43 amyloidosis, familial visceral 9.3 TTR GSN B2M APOA1
44 peripheral nervous system disease 9.1 TTR PMP22 MFN2 MAG H3-2 B2M
45 neuropathy 8.9 TTR PMP22 MFN2 MAG GSN APOA1
46 polyneuropathy 8.9 TTR PMP22 MFN2 MAG GSN APOA1
47 disease of mental health 8.6 TTR MFN2 MAG H3-2 GSN B2M

Graphical network of the top 20 diseases related to Asymmetric Motor Neuropathy:



Diseases related to Asymmetric Motor Neuropathy

Symptoms & Phenotypes for Asymmetric Motor Neuropathy

MGI Mouse Phenotypes related to Asymmetric Motor Neuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.17 APOA1 B2M GSN MAG MFN2 PMP22

Drugs & Therapeutics for Asymmetric Motor Neuropathy

Search Clinical Trials , NIH Clinical Center for Asymmetric Motor Neuropathy

Genetic Tests for Asymmetric Motor Neuropathy

Anatomical Context for Asymmetric Motor Neuropathy

Publications for Asymmetric Motor Neuropathy

Articles related to Asymmetric Motor Neuropathy:

# Title Authors PMID Year
1
Acute intermittent porphyria with peripheral neuropathy: a follow-up study after hematin treatment. 61
17459418 2007
2
[A case of hereditary neuropathy with liability to pressure palsies (HNPP) with diabetes mellitus]. 61
8797209 1996
3
Motor neuropathy with proximal multifocal persistent conduction block, fasciculations and myokymia. Evolution to tetraplegia. 61
3024989 1986

Variations for Asymmetric Motor Neuropathy

Expression for Asymmetric Motor Neuropathy

Search GEO for disease gene expression data for Asymmetric Motor Neuropathy.

Pathways for Asymmetric Motor Neuropathy

Pathways related to Asymmetric Motor Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.27 TTR APOA1

GO Terms for Asymmetric Motor Neuropathy

Cellular components related to Asymmetric Motor Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myelin sheath GO:0043209 8.62 MAG GSN

Biological processes related to Asymmetric Motor Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.5 TTR GSN B2M
2 negative regulation of neuron projection development GO:0010977 9.26 MAG B2M
3 retinoid metabolic process GO:0001523 9.16 TTR APOA1
4 amyloid fibril formation GO:1990000 8.96 GSN B2M
5 cellular protein metabolic process GO:0044267 8.92 TTR GSN B2M APOA1

Sources for Asymmetric Motor Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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